CN104432069A - Gastrointestinal smoothening tablets - Google Patents
Gastrointestinal smoothening tablets Download PDFInfo
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- CN104432069A CN104432069A CN201410801528.9A CN201410801528A CN104432069A CN 104432069 A CN104432069 A CN 104432069A CN 201410801528 A CN201410801528 A CN 201410801528A CN 104432069 A CN104432069 A CN 104432069A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses gastrointestinal smoothening tablets for regulating gastrointestinal smoothness. The gastrointestinal smoothening tablets comprise the following components in percentage by weight: 20-40 percent of water-soluble dietary fibers, 8-30 percent of fructus perillae powder, 12-28 percent of fruit-vegetable powder, 5-16 percent of probiotics powder and the balance of auxiliary materials. According to the gastrointestinal smoothening tablets disclosed by the invention, the fruit-vegetable powder can be rapidly absorbed by the intestines and stomach, the gastrointestinal balanced nutrition is regulated, the intestinal flora balance can be maintained by virtue of the dietary fibers and various probiotics, growth of harmful bacteria is inhibited, and the gastrointestinal motility is promoted. Moreover, the various components are enriched in mineral substances, vitamins and other nutrient elements, the utilization rate of nutrient substances can be promoted, and the gastrointestinal smoothening tablets are scientific and reasonable in composition, natural in components, convenient to take, obvious in effect and mild in characters, do not have any toxic or side effect and do not have dependence in long-term administration.
Description
Technical field
The present invention relates to the dietetic product changing food nutrition character, unobstructed of especially a kind of stomach regulating intestines and stomach unobstructed.
Background technology
We know, along with the raising of people's living standard and the change of dietary structure, constipation has become the common disease of modern society, and it can cause the change of people's mood, affects daily life and work.Constipation also can cause perianal as rectitis, anal fissure, hemorrhoid etc.; In addition, because of difficult defecation, ight soil drying, directly can cause or increase the weight of anal orifice and rectal intestine illness, also can bring out parenteral complication, as cerebral apoplexy, affecting cerebral function (decrease of memory, dispersion attention, thought slowness), sexual life obstacle etc.; The carcinogen that long-term constipation also can make enteric bacterial fermentation and produce stimulates Intestinal epithelial cells, causes special-shaped hyperplasia, easily brings out canceration.
At present, health food market being improved intestines and stomach function is a lot.Such as, number of patent application is " a kind of Chinese medicinal tablet for constipation " of 200810101173.7, it be by rheum officinale, fructus cannabis, brush-cherry seed, semen armeniacae amarae, the bark of official magnolia, the tuber of dwarf lilyturf, Fructus Hordei Germinatus, Ligusticum wallichii, the bighead atractylodes rhizome, the dried immature fruit of citron orange, dried orange peel totally ten a herb materials according to certain weight proportion, take to concentrate after effective component extracting, drying, the processes such as pulverizing tablet.Chinese medicinal tablet in this patent application mainly traditional Chinese medicine ingredients, containing this irritant laxative composition of rheum officinale, long-term taking, produces drug dependence and has side effects, as drug enteritis.
Summary of the invention
Regulate in the unobstructed product of intestines and stomach and all there is to overcome in prior art it deficiency that side effect is large, dependence is strong containing Chinese medicinal ingredients, the object of this invention is to provide a kind of form scientific and reasonable, composition is natural, taking convenience, to have no side effect safely, unobstructed of the stomach of Be very effective.
The technical solution adopted for the present invention to solve the technical problems is: unobstructed of a kind of stomach, it is characterized in that: it is made up of the component of following weight percents: water-soluble dietary fiber 20 ~ 40%, perilla seed powder 8 ~ 30%, fruit vegetable powder 12 ~ 28%, probiotic powder 5 ~ 16%, all the other are auxiliary material, and the percentage by weight sum of each component is 100%.
Further, described auxiliary material is made up of starch, microcrystalline cellulose and dolomol, and wherein, the percentage by weight of described starch is 8 ~ 30%, the percentage by weight of described microcrystalline cellulose is 8 ~ 25%, and the percentage by weight of described dolomol is 0.5 ~ 3%.
Precedence technique scheme of the present invention is: the percentage by weight of described each component is: water-soluble dietary fiber 28%, perilla seed powder 20%, fruit vegetable powder 18%, probiotic powder 10%, auxiliary material 24%; Wherein, in described auxiliary material, the percentage by weight of starch is 12%, and the percentage by weight of described microcrystalline cellulose is 9.5%, and the percentage by weight of described dolomol is 2.5%.
The present invention makes tablet according to selecting main materials and auxiliary materials to can be passed through the operations such as sieve, mixing, granulation, compressing tablet.Its concrete preparation technology belongs to prior art, repeats no more.
Usage of the present invention and consumption are: adult's recommended amounts every day is 3.2g.Be every day 2 times by human body recommended intake, each 2, can long-term taking.
The present invention be choose water-soluble dietary fiber, perilla seed powder, fruit vegetable powder, probiotic powder be primary raw material.Wherein each component effect is as follows: soluble dietary fiber can stimulate intestines peristalsis, is conducive to ight soil and discharges, can Constipation, the carcinoma of the rectum, hemorrhoid and varix of lower limb; Produce satiety when taking, slow down digestion rate and increase excretion of cholesterol, noxious material also can be helped to excrete, improve gut flora, safeguard that human body stomach is healthy.Its instant capacity is good, mouthfeel is good, not easily precipitate; Nutritious, balanced, be known as the 7th nutrient by Food Science circle; Containing the grease that a large amount of leukotrienes, linoleic acid, oleic acid etc. are useful to human body in perilla seed powder, face protein, vitamin, amino acid whose content are also very high.Perilla seed powder has very high nutritive value, and it has low sugar, high microsteping, high carotene, high mineral element, has appetizing and falls inverse, wide intestines profit effect just; Fruit vegetable powder is rich in abundant dietary fiber and various vitamin and trace element, can regulate gastrointestinal peristalsis by stimulating digestion, and increases immunity, is anti-ageing, improves skin, promotes human body natural's purification and functions of expelling toxin; Probio mainly comprises Bifidobacterium class and lactobacillus class, can will generate lactic acid and acetic acid after sugar decomposition, and make enteron aisle be acid, it can control by harmful microbial abnormal fermentation, and stimulates enterocinesia, plays the effect removing constipation.Unobstructed of intestines and stomach of the present invention, stomach is had no stimulation, good clean, purging and intestine lubricating action can be played, fruit vegetable powder can be absorbed fast by stomach, adjustment stomach is balanced in nutrition, dietary fiber and various probio can maintain gut flora balance, suppress harmful bacterial growth, promote enterogastric peristalsis, and each component contains abundant minerals and vitamins and other nutrients, the utilization rate of nutriment can be promoted, Be very effective simultaneously, proterties is gentle, without any side effects, and long-term taking does not have dependence.Compared with prior art, the present invention form scientific and reasonable, composition is natural, taking convenience, safety have no side effect, Be very effective, there is adjustment functions of intestines and stomach, promote the unobstructed effect of intestines and stomach.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Raw materials usedly in the present embodiment be commercial products, wherein,
Soluble dietary fiber purchased from the prosperous space in Qingdao, dietary fiber content >=90%.This soluble dietary fiber can stimulate intestines peristalsis, is conducive to ight soil and discharges, can Constipation, the carcinoma of the rectum, hemorrhoid and varix of lower limb; Produce satiety when taking, slow down digestion rate and increase excretion of cholesterol, noxious material also can be helped to excrete, improve gut flora, safeguard that human body stomach is healthy.Its instant capacity is good, mouthfeel is good, not easily precipitate; Nutritious, balanced, be known as the 7th nutrient by Food Science circle;
Perilla seed powder is beautiful purchased from Dalian ginseng.Containing the grease that a large amount of leukotrienes, linoleic acid, oleic acid etc. are useful to human body in this perilla seed powder, face protein, vitamin, amino acid whose content are also very high.Perilla seed powder has very high nutritive value, and it has low sugar, high microsteping, high carotene, high mineral element, has appetizing and falls inverse, wide intestines profit effect just.
Fruit vegetable powder ties up diligent biology purchased from Shanghai white.This fruit vegetable powder is rich in abundant dietary fiber and various vitamin and trace element, can regulate gastrointestinal peristalsis by stimulating digestion, and increases immunity, is anti-ageing, improves skin, promotes the desirable body-building food of human body natural's purification and functions of expelling toxin.
Probiotic powder is purchased from promise Shen, Shanghai, and its content is>=5.0 × 10
7.This probio mainly comprises Bifidobacterium class and lactobacillus class, can will generate lactic acid and acetic acid after sugar decomposition, and make enteron aisle be acid, its result can control by harmful microbial abnormal fermentation, and stimulates enterocinesia, plays the effect removing constipation.
In unobstructed of intestines and stomach of the present invention, fruit vegetable powder can be absorbed fast by stomach, adjustment stomach is balanced in nutrition, and dietary fiber and various probio can maintain gut flora balance, suppress harmful bacterial growth, promote enterogastric peristalsis, and each component contains abundant minerals and vitamins and other nutrients, the utilization rate of nutriment can be promoted, Be very effective simultaneously, proterties is gentle, without any side effects, and long-term taking does not have dependence.
embodiment 1
A kind of unobstructed of stomach, it is made up of the component of following weight percents: water-soluble dietary fiber 28%, perilla seed powder 20%, fruit vegetable powder 18%, probiotic powder 10%, auxiliary material 24%; Wherein, auxiliary material is made up of starch, microcrystalline cellulose and dolomol, and the percentage by weight of starch is 12%, and the percentage by weight of microcrystalline cellulose is 9.5%, and the percentage by weight of dolomol is 2.5%.According to the proportioning that the present embodiment provides, tablet forming technique is conveniently pressed into tablet.Its composition is scientific and reasonable, composition is natural, taking convenience, safety have no side effect, and regulate functions of intestines and stomach, promotes that effect that intestines and stomach is unobstructed is remarkable.
embodiment 2
A kind of unobstructed of stomach, it is made up of the component of following weight percents: water-soluble dietary fiber 20%, perilla seed powder 8%, fruit vegetable powder 15%, Bifidobacterium powder 8%, lactobacillus powder 8%, auxiliary material 41%.Wherein, auxiliary material is made up of starch, microcrystalline cellulose and dolomol, and the percentage by weight of starch is 30%, and the percentage by weight of microcrystalline cellulose is 8%, and the percentage by weight of dolomol is 3%.According to the proportioning that the present embodiment provides, tablet forming technique is conveniently pressed into tablet.Its composition is scientific and reasonable, composition is natural, taking convenience, safety have no side effect, and regulate functions of intestines and stomach, promotes that effect that intestines and stomach is unobstructed is remarkable.
embodiment 3
A kind of unobstructed of stomach, it is made up of the component of following weight percents: water-soluble dietary fiber 40%, perilla seed powder 9.5%, fruit vegetable powder 12%, Bifidobacterium powder 3%, lactobacillus powder 2%, auxiliary material 33.5%.Wherein, auxiliary material is made up of starch, microcrystalline cellulose and dolomol, and the percentage by weight of starch is 8%, and the percentage by weight of microcrystalline cellulose is 25%, and the percentage by weight of dolomol is 0.5%.According to the proportioning that the present embodiment provides, tablet forming technique is conveniently pressed into tablet.Its composition is scientific and reasonable, composition is natural, taking convenience, safety have no side effect, and regulate functions of intestines and stomach, promotes that effect that intestines and stomach is unobstructed is remarkable.
embodiment 4
A kind of unobstructed of stomach, it is made up of the component of following weight percents: water-soluble dietary fiber 20%, perilla seed powder 30%, fruit vegetable powder 28%, Bifidobacterium powder 3%, lactobacillus powder 2%, auxiliary material 17%; Wherein, auxiliary material is made up of starch, microcrystalline cellulose and dolomol, and the percentage by weight of starch is 8%, and the percentage by weight of microcrystalline cellulose is 8%, and the percentage by weight of dolomol is 1%.According to the proportioning that the present embodiment provides, tablet forming technique is conveniently pressed into tablet.Its composition is scientific and reasonable, composition is natural, taking convenience, safety have no side effect, and regulate functions of intestines and stomach, promotes that effect that intestines and stomach is unobstructed is remarkable.
carry out zoopery with unobstructed of stomach given by embodiment 1 below, further illustrate the function that the present invention has fat-reducing and detoxicating intestine.
1) materials and methods
1.1) sample: unobstructed of the stomach provided according to the embodiment of the present invention 1 is sample, 500mg/ sheet.Adult's recommended amounts every day is 1000mg/60kg.BW.Solvent preparation tested material is made with edible vegetable oil.
1.2) animal used as test: the male mice in kunming provided by Traditional Chinese Medicine Research Institute, Sichuan Province Experimental Animal Center 150, body weight 18 ~ 22g, experimental animal room is SPF level, and temperature is 20 ~ 25 DEG C, relative humidity 40 ~ 70%.
1.3) dosage choice: animal subject establishes 167mg/kg.BW, 333mg/kg.BW, 500mg/kg.BW tri-dosage groups (being equivalent to 10 times of human intaking amount, 20 times, 30 times).Respectively with Refrigerator store after edible vegetable oil to 250ml mixing, be finished and join again.Separately establish negative control group and model control group.
1.4) instrument and material
Instrument and reagent: 1/0,000 assay balances, animal balance, operating scissors, eye scissors, surgical forceps, ruler, compound diphenoxylate are provided by Changzhou Kangpu Pharmaceutical Co., Ltd., gum arabic, active carbon.
1.5) experimental technique: select male mice in kunming 75, is divided into basic, normal, high three dosage groups and negative control group, model control group, often organizes 15 animals.Three dosage per os gavages give tested material, negative control group and model control group give edible vegetable oil with approach, by 20ml/kg.BW gavage every day once, when giving off-test in 14 days continuously, each treated animal fasting can't help water 16 hours, compound diphenoxylate suspension (concentration is 0.05%) is given in a mensuration dosage group on the same day and model control group, negative control group gives distilled water, after 30 minutes, each test group of animals gives the prepared Chinese ink containing given the test agent, negative control group and model control group mouse prepared Chinese ink gavage, the all single cage of animal is fed, normal water is taken food, the time of every animal first grain row melena is recorded from filling with prepared Chinese ink, grain number and the weight of melena is arranged in 6 hours.
1.6) statistics of experimental data: experimental data adopts the process of SPSS 11.0 for windows software kit.The data of control group and dosage group are through homogeneity test of variance, and variance is neat, carries out variance analysis, as P value is less than 0.05, then compares between two by Dunnett method; If heterogeneity of variance, then carry out data conversion, still uneven, use rank test instead, as P value is less than 0.05, then compare between two by Dunnett sT3 method.Model control group and negative control group adopt T to check.
2) result
2.1) product is on the impact of Mouse Weight:
Table 1 product first grain row's melena time, grain number, balance meassurement are on the impact (`x of Mouse Weight
+s)
From table 1: the original body mass of three dosage group mouse is compared with negative control group, model control group, through statistical procedures, variance neat (P>0.05), and the results of analysis of variance (P>0.05), illustrate that the original body mass between them is balanced.Body weight at the end of three Dose Groups Study compares with model control group, through statistical procedures, and there was no significant difference (P>0.05).The continued weight of duration of test three dosage treated animals reduces, and has no each dosage treated animal and occurs diarrhoea phenomenon.
2.2) product is on the impact of detoxicating intestine effect in Mice Body
Table 2 product is on the impact of detoxicating intestine effect in Mice Body
| Grouping | Dosage | Number of animals | First grain is discharged feces the just time | Defecation grain number in 6h | Defecation weight in 6h |
| mg/kg.BW | (only) | (minute) | (grain) | （g） | |
| Negative control group | 0 | 15 | 93.63 +19.67 | 34.40 +4.12 | 0.58 +0.06 |
| Model control group | 0 | 15 | 141.27 +31.39 | 23.13 +2.72 | 0.49 +0.03 |
| Low dose group | 167 | 15 | 123.73 +14.47 | 26.07 +3.35 | 0.54 +0.06 |
| Middle dosage group | 333 | 15 | 129.93 +17.52 | 26.53 +4.75 | 0.52 +0.08 |
| High dose group | 500 | 15 | 115.07 +14.99 | 28.60 +4.05 | 0.54 +0.05 |
In table 2, compared with negative control group, row's fecal grains and row's stool weight in model control group little mouse's head grain row's melena time, 6h, through statistical procedures, there were significant differences (P<0.01, P<0.01, P<0.01), and it is successful for illustrating that this model is set up.Three dosage group little mouse's head grain row's melena times, 6h interior row fecal grains and row's stool weights are compared with model control group, through statistical procedures, there is remarkable shortening (P<0.05) high dose group first grain row's melena time, just grain digital display work of discharging feces in middle high dose group 6h increases (P<0.05, P<0.01), and low high dose group 6h arranges stool weight significantly to be increased (P<0.05, P<0.05).
3) brief summary
After giving male mice in kunming by continuous 14 days per os gavages, the body weight of visual animal decreases, and has no phenomenon of significantly suffering from diarrhoea.Under the prerequisite that model is successfully established, there is remarkable shortening (P<0.05) tested material middle and high dosage group first grain row's melena time, just grain digital display work of discharging feces in middle high dose group 6h increases (P<0.05, P<0.01), and in low high dose group 6h, row's stool weight significantly increases (P<0.05, P<0.05).In sum, this invention has obvious detoxicating intestine effect, and it improves function of intestinal canal animal test results for positive.
Claims (3)
1. unobstructed an of stomach, it is characterized in that: it is made up of the component of following weight percents: water-soluble dietary fiber 20 ~ 40%, perilla seed powder 8 ~ 30%, fruit vegetable powder 12 ~ 28%, probiotic powder 5 ~ 16%, all the other are auxiliary material, and the percentage by weight sum of each component is 100%.
2. unobstructed of a kind of stomach according to claim 1, it is characterized in that: described auxiliary material is made up of starch, microcrystalline cellulose and dolomol, wherein, the percentage by weight of described starch is 8 ~ 30%, the percentage by weight of described microcrystalline cellulose is 8 ~ 25%, and the percentage by weight of described dolomol is 0.5 ~ 3%.
3. unobstructed of a kind of stomach according to claim 2, the percentage by weight of described each component is: water-soluble dietary fiber 28%, perilla seed powder 20%, fruit vegetable powder 18%, probiotic powder 10%, auxiliary material 24%; Wherein, in described auxiliary material, the percentage by weight of starch is 12%, and the percentage by weight of described microcrystalline cellulose is 9.5%, and the percentage by weight of described dolomol is 2.5%.
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