CN103478508A - Chinese medicinal composition and feed for improving chicken immunity and preparation method of composition and feed - Google Patents
Chinese medicinal composition and feed for improving chicken immunity and preparation method of composition and feed Download PDFInfo
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Abstract
The invention discloses a feed for improving chicken immunity. The feed is characterized by comprising the following raw materials: corns, soybean meal, wheat, rice bran meal, a vitamin premix, a microelement premix, common salt, calcium bicarbonate, an antioxidant and a Chinese medicinal additive. The feed disclosed by the invention has the beneficial effects that the feed containing a Chinese medicinal composition can overcome various defects of Chinese medicines and Western medicine in the prior art, the immunity and productivity of chickens are improved, and the feed has the advantages of no toxic or side effect, less possibility of relapse, no medicinal hazards and the like.
Description
Technical field
The present invention relates to the mixed feed of chicken, particularly a kind of for the Chinese medicine composition that improves chicken immunity, feed and preparation method thereof.
Background technology
Immunity is the defense mechanism of self, is identification and any foreign matter (virus, bacterium etc.) of eliminating external intrusion; Process the ability of self cell and identification and processing vivo mutations cell and the virus infected cell of old and feeble, damage, dead, sex change.Modern immunology thinks, immunity is identification and the physiological reaction of getting rid of " dissident ".
Today various bird flus flourish in China's poultry husbandry are all the fashion.At chemicalses such as the various antibiotic of application, remain for preventing and treating the first-selection of infectious disease and parasitic disease.This not only causes the appearance of a large amount of drug-fast bacterias, worm strain, and cause residual in various chicken and products thereof of chemicals, bring very big infringement to public health and food security, more do not meet people's's " high-quality, low medicine is residual, green non-pollution " food consumption trend.The consumption that livestock products will meet people requires just must find a kind of safe production model, and raise, is first to be vital link.As can be seen here, find a kind of not only safe and effective but also alternative antibiotic medicine and seem particularly important.
Animal immune system is that animal is evolved gradually and improves in germline generation and ontogenetic process, is the organization that body is carried out immunologic function, is the material base that produces immune response.Animal immune system is comprised of immune organ, immunocyte and immune molecule.All participation immune responses or the cell relevant to immune response are referred to as immunocyte.Function and effect mechanism according to them in immune response, can be divided into immunocompetent cell and the large class of immune accessory cell two.Also have in addition some other cells, such as K cell, NK cell, granulocyte, red blood cell etc., also participated in some specific links of certain in the immune response.
In recent years, in fowl produces, ubiquity vaccine immunization preventive effect is bad, and dosage strengthens gradually and does not still reach desirable treatment and preventive effect, this is to descend because a large amount of for a long time drug abuse and irrational vaccine inoculation cause the livestock and poultry body's immunity, particularly at a low ebb the or holddown of the immunocyte such as lymphocyte, macrophage; The fast development of aquaculture, the food of let us is abundanter, still due to deterioration and the antibiotic abuse of breeding environment, causes cultivated animals anti-adversity ability, immunocompetence, anti-stress ability to reduce.And the decline of the production efficiency of being brought by the animal inferior health, dead, disability rate raises, and causes aquaculture cost to strengthen; Autoimmunity low, the antibiotic abuse that disease-susceptible humans is caused out, cause the enhancing of bacterial resistance bacterium property, to the harm of human health etc. these problems, make us have to again pay close attention to animal health, adopt an effective measure, do health-care feed, strengthen the animal daily health caring, improve animal autoimmunity ability and make China's feed industry and aquaculture go on the road of Sustainable Healthy Development.The effect that animal health plays, impel animal body to be transformed to healthy direction by sub-health state exactly, stops it to transform to the direction of disease, do not make animal clinical symptoms occur or reduce the probability that animal falls ill.The process of physical health is a kind of process prevented trouble before it happens, and is a kind of gradual conditioning.When the every function of body, all in animated period, when body is in the pink of condition, the health products effect is also not obvious, but works as body in sub-health state or physiological function decline, and autoimmunity descends, and during to disease-susceptible humans, health-care effect will display.The chemicals immunopotentiator is existing and reduce the body production performance in various degree all, causes toxic and side effect and medicament residue, and the drawback such as be detrimental to health.
Chinese medicine is the rarity of China, and existing long history, have again unique curative effect.Chinese medicine is natural animals and plants or mineral matter, itself contains abundant vitamin, mineral matter and protein, can supplement the nutrients, the effect that growth promotion is arranged again, strengthens domestic animal physique, improves body resistance against diseases.Motherland's traditional medicine just proposed famous " strengthening vital QI to eliminate pathogenic factors " principle of reatment before over thousands of year." just " just refer to Abwehrkraft des Koepers, " heresy " refers to paathogenic factor.With the modern medicine language, strengthen exactly human body immune function, can resist the invasion and attack of paathogenic factor.Half a century, the veterinary work person of China has opened up the new application of Chinese medicine, has implemented new study route, has formed new production technology.Regulate the animal immunity function as the development of colony's medication of herbal medicine and feed addictive, herbal medicine as health products, herbal medicine and on the new technology of the herbal medicines such as the impact of animal microecological, ultramicro grinding and the application of biotechnology in Chinese medicine is produced etc.
The Chinese herbal medicine nature that has drawn from, and, there is hypertoxic herbal medicine few, and use clinically relatively standard, so Chinese herbal medicine can be more safer than Chinese patent drug and Western medicine, respond well for improving chicken immunity.Because Chinese herbal medicine has the dual-use function of nutrition and health care, Chinese medicine is under different conditions, for different objects, can show the effect that promotes or suppress body's immunity, this is that the unique and complex property of medicine of Chinese medicine determines, be also the imbody of differentiation of tcm viewpoint, in livestock and poultry cultivation, use Chinese medicine immunity enhancer improve the immune level of body and anti-parasitic-infectiously be subject to common concern.
Summary of the invention
Technical problem to be solved by this invention is, a kind of feed that improves chicken immunity is provided, according to the physilogical characteristics of chicken, the appropriate Chinese medicine additive that adds scientific formula in the daily ration of chicken, effectively improving immunity, the generation of keeping off infection property disease, enhancing, to invasive organism and parasitic resistance, improves survival rate, when promoting growth, good palatability, bioavilability is high.
In order to realize the foregoing invention purpose, the invention provides a kind ofly for improving the feed of chicken immunity, described feed comprises following raw material: corn, dregs of beans, wheat, rice bran meal, vitamin premix, microelement pre-mix material, salt, calcium bicarbonate, antioxidant and Chinese medicine additive.
Described feed can be comprised of the raw material of following ratio of weight and number: corn 200-400 part, dregs of beans 250-433 part, wheat 50-140 part, rice bran meal 50-170 part, vitamin premix 5-9 part, microelement pre-mix material 5-8 part, salt 2-6 part, calcium bicarbonate 5-9 part, antioxidant 2-7 part and Chinese medicine additive 5-15 part.
Described Chinese medicine additive is comprised of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 10-34 part, Chinese cassia tree 10-30 part, Ligusticum wallichii 10-36 part, Amomum cardamomum 10-28 part, test 10-45 part, flexuose bittercress herb and seed 13-32 part, oiltea camellia seed 13-29 part, Huang 16-28 part over sixty years of age, the blue 8-45 part of thumb, mile swertia herb 13-40 part, root of herbaceous peony 13-45 part, flos caryophylli 17-40 part, fore-telling mustard 10-24 part, testis et penis canitis 14-23 part, faenum graecum 8-38 part and HERBA EPIMEDII 17-34 part.
Described Chinese medicine additive can be comprised of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 15-30 part, Chinese cassia tree 13-25 part, Ligusticum wallichii 16-31 part, Amomum cardamomum 14-22 part, test 19-35 part, flexuose bittercress herb and seed 18-27 part, oiltea camellia seed 18-21 part, Huang 19-25 part over sixty years of age, the blue 17-32 part of thumb, mile swertia herb 19-26 part, root of herbaceous peony 21-34 part, flos caryophylli 20-38 part, fore-telling mustard 13-21 part, testis et penis canitis 17-21 part, faenum graecum 17-31 part and HERBA EPIMEDII 19-31 part.
Described Chinese medicine additive can also be comprised of the raw medicinal material of following ratio of weight and number: 21 parts of Radix Codonopsis, 18 parts of Chinese cassia trees, 23 parts of Ligusticum wallichiis, 18 parts of Amomum cardamomums, test 25 parts, 23 parts of flexuose bittercress herb and seeds, 19 parts of oiltea camellia seeds, 21 parts of yellow over sixty years of ages, blue 25 parts of thumb, 23 parts of mile swertia herbs, 27 parts of the root of herbaceous peonys, 29 parts of flos caryophyllis, foretell 17 parts, mustard, 25 parts of 19 parts of testis et penis canitises, 24 parts of faenum graecums and HERBA EPIMEDIIs.
The preparation method of described Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, be ground into powder after mixing;
Second step, the first step is obtained to powder add in cold water and to soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3～5 times of the powder quality that obtains of the first step;
The 3rd step, the filter residue that second step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtered fluid, obtain the second filtrate, identical in the quality of the water added and second step;
The 4th step, the first filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into to spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 orders～400 orders, obtain the Chinese medicine composition powder.
In order better to realize the foregoing invention purpose, the present invention also provides a kind of preparation method for the feed that improves chicken immunity, and described preparation method comprises the following steps:
The first step, the preparation of described Chinese medicine composition additive;
Second step, feed vector is ground into to 100 orders～200 purpose powder, the Chinese medicine composition powder obtained with the 3rd step mixes, pour in the granulating disc that is placed in heeling condition, open granulating disc and make its rotation, while is evenly sprayed the starch solution of vaporific 20% concentration to the mixture in granulating disc, the weight of described starch solution is 1/5～1/10 of described mixture quality, the rotating speed of granulating disc is 50 rev/mins, preparation time is 15 minutes, the spherical particle feed that to be prepared into diameter be 0.8 millimeter;
The 3rd step, the spherical particle feed that second step is obtained, spread on the mesh-belt drier with the portable stainless steel guipure of multilayer, heat drying 10 minutes, the import air temperature of heating is 150 degree, the outlet air temperature is 80 degree, obtains dry feed granules.
The described first step comprises: according to ratio of weight and number weighting raw materials material, be ground into powder after mixing; Above-mentioned steps is obtained to powder and add in cold water and to soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the dregs of a decoction are standby, and the quality of the water added is 3～5 times of the powder quality that obtains; The filter residue that above-mentioned steps filter is obtained adds in cold water again, with slow fire boiling 2～4 times, decocts 1 hour～2 hours at every turn, filters and merges filtered fluid, obtains the second filtrate, and the quality of the water added and above-mentioned steps add quality identical of water; The first filtrate and the second filtrate are merged, and reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into to spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 orders～400 orders, obtain the Chinese medicine composition powder.
It is a kind of for improving the Chinese medicine composition of chicken immunity that the present invention also provides, and described Chinese medicine composition is comprised of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 10-34 part, Chinese cassia tree 10-30 part, Ligusticum wallichii 10-36 part, Amomum cardamomum 10-28 part, test 10-45 part, flexuose bittercress herb and seed 13-32 part, oiltea camellia seed 13-29 part, Huang 16-28 part over sixty years of age, the blue 8-45 part of thumb, mile swertia herb 13-40 part, root of herbaceous peony 13-45 part, flos caryophylli 17-40 part, fore-telling mustard 10-24 part, testis et penis canitis 14-23 part, faenum graecum 8-38 part and HERBA EPIMEDII 17-34 part.
The preparation method of described Chinese medicine composition is as follows:
The first step, according to ratio of weight and number weighting raw materials material, be ground into powder after mixing;
Second step, the first step is obtained to powder add in cold water and to soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3～5 times of the powder quality that obtains of the first step;
The 3rd step, the filter residue that second step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtered fluid, obtain the second filtrate, identical in the quality of the water added and second step;
The 4th step, the first filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into to spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 orders～400 orders, obtain the Chinese medicine composition powder.
The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: the present invention adopts the Feed Energy that contains Chinese medicine composition to overcome the various defects of Chinese medicine of the prior art and Western medicine, improve immunity and the production performance of chicken, have and have no side effect, be difficult for recurrence, without poisoning, low cost and other advantages.
The specific embodiment
Embodiment 1 Chinese traditional medicine composition composition powders
It is a kind of for improving the Chinese medicine composition of chicken immunity that the embodiment of the present invention provides, and Chinese medicine additive is comprised of the raw medicinal material of following ratio of weight and number: 21 parts of Radix Codonopsis, 18 parts of Chinese cassia trees, 23 parts of Ligusticum wallichiis, 18 parts of Amomum cardamomums, test 25 parts, 23 parts of flexuose bittercress herb and seeds, 19 parts of oiltea camellia seeds, 21 parts of yellow over sixty years of ages, blue 25 parts of thumb, 23 parts of mile swertia herbs, 27 parts of the root of herbaceous peonys, 29 parts of flos caryophyllis, foretell 17 parts, mustard, 25 parts of 19 parts of testis et penis canitises, 24 parts of faenum graecums and HERBA EPIMEDIIs.
The preparation method of Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, be ground into powder after mixing;
Second step, the first step is obtained to powder add in cold water and to soak 24 hours, with slow fire boiling, decocting time is 2 hours, and decoction liquor is filtered, and obtains the first filtrate, and the quality of the water added is 4 times of the powder quality that obtains of the first step;
The 3rd step, the filter residue that second step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1.5 hours at every turn, filter and merge filtered fluid, obtain the second filtrate, identical in the quality of the water added and second step;
The 4th step, the first filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, and dry cream is put into to spray dryer dry, guarantees that EAT is at 180 ℃, and 70 ℃ of leaving air temps, be ground into 300 orders subsequently, obtains the Chinese medicine composition powder.
Long term toxicity test
Get 10 of Adult Chickens, body weight is at 2.5～3kg, male and female half and half, 10 of children chickens, male and female half and half, body weight is at 0.5kg～1kg, 10 months long-term powder of giving embodiment 1, carry out long term toxicity test, the index such as result shows all chicken general status, grows, routine blood test, liver, renal function is showed no abnormal change, and Histopathology and gross necropsy also have no pathological change.Toxicity test proves, the not toxic effect of this medicine and bad reaction, and clinical practice is safe and reliable.
Wherein, the pharmacological property of each raw medicinal material is as follows:
Radix Codonopsis: there is tonifying middle-Jiao and Qi, the effect of invigorating the spleen benefit lung.For a little less than the spleen deficiency syndrome of the lung, the palpitaition of breathing hard, anorexia and loose stool, void is breathed with cough and is coughed, and interior heat is quenched one's thirst etc.Modern study, Radix Codonopsis is containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, saponin and Alkaloid, has immunity, hemangiectasis, the step-down of enhancing, improves microcirculation, strengthens the effect such as hematopoiesis function.The leucocyte in addition chemotherapy radiotherapy caused descends castering action." new compilation of materia medica " record: " tonifying middle-Jiao and Qi and taste, relieving thirst and restlessness.Middle gas is faint, in order to adjust, mends, very smooth and proper.”
Chinese cassia tree: suffering, temperature cures mainly:, trusted subordinate crymodynia cold for impotence, palace, the cold of insufficiency type vomit and diarrhoea, through closing, dysmenorrhoea, warming meridians and promoting circulation of qi.Function cures mainly: mend fire supporing yang, let the fire back to its origin, eliminating cold to stop pain, activating blood to promote menstruation.Warming spleen and stomach, removing internal cold, promoting blood circulation.Control the Yang-function insufficiency of kidneyzang, the cold weak pulse of limb, yang depletion collapse, stomachache is had loose bowels, the cold hernia globefish that runs quickly, waist knee crymodynia, through closing abdominal mass, cloudy subcutaneous ulcer, streamer, and empty sun is more floating, heat in the upper and cold in the lower.
Ligusticum wallichii: ligustrazine energy coronary artery dilator, increase coronary blood flow, improve myocardium blood oxygen supply, and reduce myocardium oxygen demand; The expansible cerebrovascular of ligustrazine, reduce vascular resistence, significantly increases brain and LBF amount, improves microcirculation; Can reduce surface activity of blood platelet, suppress platelet aggregation, the formation of pre-preventing thrombosis; The neutral compound of contained forulic acid is low dose of to be promoted, heavy dose of uterine smooth muscle that suppresses; Water decoction has sedation to the animal central nervous system, and obvious and lasting hypotensive effect is arranged; Can accelerate the to fracture absorption of local hematoma, promote poroma to form; The effect of antivitamin E shortage is arranged; Can suppress multiple bacillus; Antihistaminicum and choleretic effect are arranged.
Amomum cardamomum: flavor is hot, warm in nature, returns lung, spleen, stomach warp, the effect dampness elimination, and promoting the circulation of qi, in temperature, preventing or arresting vomiting.The dampness elimination promoting the circulation of qi, warming middle energizer to arrest vomiting.Promoting the circulation of qi, warm stomach, help digestion, wide in.Control the stagnation of the circulation of vital energy, eat stagnant, uncomfortable in chest, abdominal distension, gas, dysphagic, tell contrary, gastric disorder causing nausea, malaria." Kaibao Bencao ": " main long-pending cold air, antiemetic is contrary, gastric disorder causing nausea, Gu Xiaqi disappears." bacteriostasis: the dull and stereotyped trench method of this product 100% shell decoction has inhibitory action to shigella dysenteriae.The contained 4-terpinol of this product has a bacteriostasis to Bacillcus thurin giensis is external.Antiasthmatic effect: α-terpineol that this product is contained, antiasthmatic effect is stronger, and during to GPTSM 0.05ml/kg dosage, effect is better than Blumea oil.The 4-terpinol also has the antiasthmatic effect shown.The stomach invigorating of tool fragrance, wind dispelling effect, cardamom oil is very unstable, even store finely, also normal its peculiar fragrance of easily losing, generally can make fragrant tincture or spirit.Seed should can grind before use, and good fragrant digestion promoting function is arranged, and can promote gastric secretion, and excited intestinal tube is wriggled, and drives away pneumatosis in intestines, and suppresses abnormal fermentation in intestines.The Amomum cardamomum decoction is to the excitement of guinea pig in vitro intestinal tube low concentration; Higher than 1% and the volatile oil saturated aqueous solution all be inhibitory action.Other effects: its volatile oil, to guinea pig experimental tuberculosis, can strengthen the effect of low dose of streptomysin.
Test: hardship; Hot; Flat.Kidney; Urinary bladder channel.Function cures mainly: wind-expelling pain-stopping; Dampness removing is treating stranguria.Main injury and bone fracture; The urine leaching pain.
Flexuose bittercress herb and seed: sweet; Light; Cool.Function cures mainly: clearing heat and promoting diuresis; Calm the nerves; Hemostasis.Main damp-heat dysentery; Heat is drenched; Leukorrhea; Palpitaition; Insomnia; Toothache caused by fire of deficiency type; Infantile malnutrition; Spit blood; Have blood in stool; Furunculosis.
Oiltea camellia seed: hardship, flat." Luchuan book on Chinese herbal medicine ": " promoting the circulation of qi is dredged stagnant.Controlling qi-stagnating abdominalgia has loose bowels." Guangzhou air force " Chinese herbal medicine handbook commonly used: " control stomachache, pruitus, burn." camellianin has antitumaous effect, the next day oral to mouse, the local carcinogen that uses, after the several months, can make the papilloma of skin and the decreased number of cutaneum carcinoma simultaneously.The local use of camellianin is invalid, while in blood, containing camellianin, antitumaous effect is arranged, and as its effect stops, the number of cutaneum carcinoma increases to the level similar to control group very soon.
The Radix Astragali: take qi-restoratives as main, energy invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation.For insufficiency of vital energy and blood, sore cave in, purulence becomes do not burst or burst and do not hold back the person for a long time.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration, i.e. the abscess suppuration myogenic of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and can strengthen the immunologic function of body, therefore can also be for preventing the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five zang organs, control arteries and veins string spontaneous perspiration, rushes down yin fire, removes lung heat, losslessly sends out, and has sweat to stop." be the good medicine of promoting resistance and defence disease.
Thumb indigo plant: Gan Xin, micro-hardship, temperature.Function cures mainly: swollen, the insufficiency of the spleen fire of inducing diuresis for removing edema, hot malicious wind Shengs, urine stranguria with turbid discharge, the lower blood of stool, and quench the thirst and reduce phlegm, brain leaks, nasal eczema, aphasia from apoplexy, dyspepsia, phlegm are long-pending, the evil sore.
Mile swertia herb: cold in nature, bitter.Function cures mainly: clearing heat and detoxicating, and relaxing liver and strengthening stomach, anti-inflammation and sterilization.Control acute icteric hepatitis, sphagitis, tonsillitis, cystitis, urethritis, influenza, flu, malaria.
The root of herbaceous peony: the root of herbaceous peony enters liver, the spleen channel, nourishing blood and liver, and slow middle pain relieving, astringe yin is received sweat.Control chest abdomen pain over the hypochondriac region, rush down dysentery stomachache, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band, married woman's blood closes obstructed, and the hemostasis that disappears can lose purulence, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, bring down a fever, relieving restlessness, beneficial gas, day hot disease of row, the pest miasma, frightened mad, married woman's blood fortune, and intestines wind, rush down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the sore scabies, headache, improving eyesight, hot eyes is exerted meat.The many tonifying Qi of redness of the skin or complexion person, white person controls blood.
Flos caryophylli: property suffering, flavor temperature.Enter lung, spleen, stomach, kidney four warps.Effect: in temperature, warm kidney, fall contrary.Cure mainly: control hiccup, vomiting, gastric disorder causing nausea, dysentery, trusted subordinate's crymodynia, Xuan addiction, hernia, ringworm.Cloves is aromatic stomachic, can alleviate abdominal bloating, increases gastric secretion, strengthens digestion power, alleviates n and V, and water decoction has inhibitory action to staphylococcus, streptococcus, Escherichia coli, typhoid bacillus, Pseudomonas aeruginosa etc.
Foretell mustard: flavor is hot; Micro-hardship; Cold in nature.1. " the practical Chinese herbal medicine in Guangxi newly selects ": " removing toxic substances is brought down a fever, Repercusion analgesia.Control hyperpyrexia, venomous snake bite, pulmonary tuberculosis, influenza, ileotyphus, cellulitis, nameless sores or boils, malicious bee sting." 2. " Chinese herbal medicine is commonly used in Sichuan ": " removing toxic substances, dissipating bind.Control scrofula, the furuncle sore, all carbuncles from the beginning of." 3. " the Guangxi medicine is planted register ": " root-like stock: control chronic osteomyelitis, leptospirosis, burn; Leaf: control carbuncle."
Testis et penis canitis: salty temperature enters kidney channel.Function: warming kidney to invigorate yang.Weak for kidney yang, positive certain herbaceous plants with big flowers seminal emission, the woman is sombre, the diseases such as soreness of waist frequent micturition.
Faenum graecum: hardship, temperature, return kidney channel.Function cures mainly kidney-replenishing, dispellieg cold and dampness.Control cold hernia, abdomen side of body turgor, the disturbance of lower legs due to pathogenic cold and dampness, the soreness of waist of suffering from a deficiency of the kidney, impotence.
HERBA EPIMEDII: flavor is hot; Sweet; Warm in nature.Return liver; Kidney channel.Effect: tonifying kidney and strengthening yang; Dispel rheumatism; Strong muscle key bone.Impotence and seminal emission; Empty cold sterile; The frequent micturition incontinence; Dyspnea and cough due to deficiency of the kidney; Soreness and weakness of waist and knees; Arthralgia due to wind-dampness; Hemiplegia; Four limbs are meciless.
Embodiment 2 Chinese medicine composition decoctions
It is a kind of for improving the Chinese medicine composition of chicken immunity that the embodiment of the present invention provides, and Chinese medicine additive is comprised of the raw medicinal material of following ratio of weight and number: 17 parts of Radix Codonopsis, 27 parts of Chinese cassia trees, 12 parts of Ligusticum wallichiis, 25 parts of Amomum cardamomums, test blue 8 parts of 37 parts, 18 parts of flexuose bittercress herb and seeds, 13 parts of oiltea camellia seeds, 28 parts of the Radixs Astragali, thumb, 36 parts of mile swertia herbs, 42 parts of the root of herbaceous peonys, 17 parts of flos caryophyllis, foretell 24 parts, mustard, 17 parts of 14 parts of testis et penis canitises, 8 parts of faenum graecums and HERBA EPIMEDIIs.
The preparation method of Chinese medicine additive comprises the following steps:
Take all raw medicinal materials according to ratio of weight and number, mix, be ground into 150 purpose powder, the water that adds 5 times of weight of powder, at the temperature of 100 ℃, decoct 40 minutes, decoction liquor is filtered, and obtains the first filtered fluid and filter residue, the filter residue of acquisition is added to the water of 1500g, at the temperature of 100 ℃, decoct 40 minutes, decoction liquor is filtered, and obtains the second filtered fluid, the first filtered fluid and the second filtered fluid are merged, obtain decoction liquor.
Acute toxicity test
(1) experimental animal: the healthy KM mouse of SPF level, 40, male and female half and half, body weight 20-25g.
(2) detect reagent: serum AST, ALT detection kit are purchased from Yadong, Laiyang biological products Co., Ltd.
(3) checkout equipment: Micro-200 semiautomatic biochemistry detector, assay balance, disscting instrument, syringe, test tube etc.
(4) test method:
After the adaptability of one week is raised, be divided at random 4 groups (male and female half and half), every group each 10; Control group, 3 various dose experimental group (are respectively 76mg (crude drug)/only, (219.9mg crude drug)/only, (357.6mg crude drug)/only), each experimental group gavages the decoction liquor of embodiment 2 preparations, mouse free choice feeding, drinking-water, in feeding process, change water every day, the next day change bedding and padding.Whole experimental period is 7 days.
(5) testing index and method
A, clinicing symptom observation: every day the viewing test mouse the state of mind, diet situation, every day entry Mortality situation.
B, pathological observation: cutd open inspection for dead mouse and observe the internal organ variation.
C, growth indexes are observed: the test mouse is carried out to routine weighing; Off-test, slaughter that mouse weighs in, the heavy organ index of internal organs measures: cut open the inspection kunming mice, dirty, the spleen of coring, liver, kidney, testis, ovary, weigh, and calculates according to the following formula organ index: organ index=internal organs weight/body weight * 100.
D, liver function change to be observed: after off-test, slaughter mouse, take the blood separation of serum, measure AST, ALT.
(6) data are processed: above the data SPSS11.0 carries out analytic statistics.
(7) clinicing symptom observation
Control group and test group mouse, the state of mind and diet are wanted, respond has no significantly abnormal to external world.Each is organized, and mouse falls ill and death condition is as shown in table 1.
The morbidity of table 1 mouse and the death condition table of comparisons
Pathological observation: control group and test group, mouse is cutd open after slaughtering to examine to observe to have no observes the obvious pathological change of internal organs.
Growth indexes is observed: off-test, slaughter that mouse weighs in, the internal organs weight analysis is as shown in table 2.
Table 2 body weight, the internal organs weight analysis table of comparisons
Liver function changes to be observed: after off-test, slaughter mouse, take the blood separation of serum, measure AST, ALT as shown in table 3.
Table 3 liver function changes the table of comparisons
The above results all shows respectively to be organized data and normal healthy controls group to compare difference not remarkable, all in normal range (NR).
Embodiment 3 feeds
It is a kind of for improving the feed of chicken immunity that the embodiment of the present invention provides, and the raw material of following ratio of weight and number, consists of: 9 parts of 312 parts of corns, 343 parts of dregs of beans, 85 parts of wheats, 110 parts of rice bran meals, 7 parts of vitamin premixs, 6 parts of microelement pre-mix materials, 4 parts of salt, 7 parts of calcium bicarbonates, 5 parts of antioxidants and Chinese medicine additives.
Wherein, Chinese medicine additive is comprised of the raw medicinal material of following ratio of weight and number: 21 parts of Radix Codonopsis, 18 parts of Chinese cassia trees, 23 parts of Ligusticum wallichiis, 18 parts of Amomum cardamomums, test blue 25 parts of 25 parts, 23 parts of flexuose bittercress herb and seeds, 19 parts of oiltea camellia seeds, 21 parts of the Radixs Astragali, thumb, 23 parts of mile swertia herbs, 27 parts of the root of herbaceous peonys, 29 parts of flos caryophyllis, foretell 17 parts, mustard, 25 parts of 19 parts of testis et penis canitises, 24 parts of faenum graecums and HERBA EPIMEDIIs.
Vitamin premix is vitamin A 27900 IU/kg, cholecalciferol 1880IU/kg, vitamin E 730IU/kg, prokeyvit 5600IU/kg, vitamin B2 2400IU/kg, pantothenic acid 3600 mg/kg; Microelement pre-mix material is copper 6500mg/kg, iron 9360mg/kg, manganese 1650mg/kg, zinc 8900mg/kg, iodine 2640mg/kg, selenium 1280mg/kg, cobalt 1130mg/kg.
The embodiment of the present invention also provides a kind of preparation method for the feed that improves chicken immunity, comprises the following steps:
The first step, the preparation of described Chinese medicine composition additive;
Second step, feed vector is ground into to 100 orders～200 purpose powder, the Chinese medicine composition powder obtained with the 3rd step mixes, pour in the granulating disc that is placed in heeling condition, open granulating disc and make its rotation, while is evenly sprayed the starch solution of vaporific 20% concentration to the mixture in granulating disc, the weight of described starch solution is 1/5～1/10 of described mixture quality, the rotating speed of granulating disc is 50 rev/mins, preparation time is 15 minutes, the spherical particle feed that to be prepared into diameter be 0.8 millimeter;
The 3rd step, the spherical particle feed that second step is obtained, spread on the mesh-belt drier with the portable stainless steel guipure of multilayer, heat drying 10 minutes, the import air temperature of heating is 150 degree, the outlet air temperature is 80 degree, obtains dry feed granules.
Wherein, the first step comprises: according to ratio of weight and number weighting raw materials material, be ground into powder after mixing; Above-mentioned steps is obtained to powder and add in cold water and to soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the dregs of a decoction are standby, and the quality of the water added is 3～5 times of the powder quality that obtains; The filter residue that above-mentioned steps filter is obtained adds in cold water again, with slow fire boiling 2～4 times, decocts 1 hour～2 hours at every turn, filters and merges filtered fluid, obtains the second filtrate, and the quality of the water added and above-mentioned steps add quality identical of water; The first filtrate and the second filtrate are merged, and reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into to spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 orders～400 orders, obtain the Chinese medicine composition powder.
Contrast test
Choose 2400 of the healthy meat chicks of 1 age in days, be divided into immediately three experimental group, every group 800, use respectively the feed (embodiment group 1) of the embodiment of the present invention 3, the conventional feed (control group) that is added with the conventional feed (embodiment group 1) of embodiment 2 Chinese medicine compositions and does not add Chinese medicine composition of the present invention to feed respectively the meat chick, 1 age in days starts feeding, and experiment periods is 21 days, sub-cage rearing, free choice feeding, freely drink water.
The mensuration of growth performance index:
When experiment starts and experiment finish to take respectively cage as the weigh empty stomach weight of experimental chicken of unit, record total feed consumption rate, and the average daily ingestion amount of experiment with computing chicken (ADFI), average daily gain (ADG) and material anharmonic ratio (F/G), and the death rate, result is as shown in Table 1 and Table 2.
The mensuration of Immune Organs Index: during 21 age in days, choosing immediately five chickens from each experimental group is slaughtered, complete excision spleen, thymus gland and the bursa of farbricius, remove surperficial connective tissue, the weigh weight in wet base of thymus gland, spleen and the bursa of farbricius, calculate bursa of farbricius index, index and spleen index and thymus index, be calculated as follows (result is as shown in table 3):
Bursa of farbricius index=(bursa of farbricius weight/body weight) * 100%;
Index and spleen index=(spleen weight/body weight) * 100%;
Thymus index=(thymus gland weight/body weight) * 100%.
Data are processed: data are expressed as " average+standard deviation ", adopt the SPSS17.0 statistical software to carry out one-way analysis of variance.
Results and analysis:
Table 1 is respectively organized the broiler growth performance table of comparisons
From the data of table 1, use the chicken of the forage feed of embodiment group one and embodiment group two, its average daily ingestion amount is higher than the chicken of control group, and its average daily gain exceeds respectively control group 3.75g and 3.17g, and its material anharmonic ratio is significantly lower than control group.
The average daily grazing rate of experimental group is compared with the second control group with the first control group, significantly reduces, and average daily gain is significantly higher than the first control group and the second control group, and the material anharmonic ratio of experimental group and the second control group is significantly lower than the first control group.
The table 2 death condition table of comparisons
As can be seen from Table 2, the feed that adopts feed of the present invention or use to be added with Chinese medicine composition of the present invention can obviously reduce the death rate of chicken.
The table 3 meat chick Immune Organs Index table of comparisons
Data from table 3: compare with the broiler chicken that conventional feed is fed, use the feed and the chicken that is added with the forage feed of the embodiment of the present invention 1 Chinese medicine composition of the embodiment of the present invention 3, its index and spleen index, thymus index and bursa of farbricius index slightly are improved.
Known by the contrast experiment, the embodiment of the present invention 1 and 2 Chinese medicine composition add the feed of conventional feed and embodiment 3 as Chinese medicine additive, all can improve production performance and the survival rate of broiler chicken, improve broiler chicken index and spleen index, thymus index and bursa of farbricius index, improved resistance against diseases and the immunity of broiler chicken.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. for improving the feed of chicken immunity, it is characterized in that, described feed comprises following raw material: corn, dregs of beans, wheat, rice bran meal, vitamin premix, microelement pre-mix material, salt, calcium bicarbonate, antioxidant and Chinese medicine additive.
2. according to claim 1 for improving the feed of chicken immunity, it is characterized in that, described feed is comprised of the raw material of following ratio of weight and number: corn 200-400 part, dregs of beans 250-433 part, wheat 50-140 part, rice bran meal 50-170 part, vitamin premix 5-9 part, microelement pre-mix material 5-8 part, salt 2-6 part, calcium bicarbonate 5-9 part, antioxidant 2-7 part and Chinese medicine additive 5-15 part.
3. according to claim 1 and 2 for improving the feed of chicken immunity, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 10-34 part, Chinese cassia tree 10-30 part, Ligusticum wallichii 10-36 part, Amomum cardamomum 10-28 part, test 10-45 part, flexuose bittercress herb and seed 13-32 part, oiltea camellia seed 13-29 part, Huang 16-28 part over sixty years of age, the blue 8-45 part of thumb, mile swertia herb 13-40 part, root of herbaceous peony 13-45 part, flos caryophylli 17-40 part, fore-telling mustard 10-24 part, testis et penis canitis 14-23 part, faenum graecum 8-38 part and HERBA EPIMEDII 17-34 part.
4. described for improving the feed of chicken immunity according to claim 1-3 any one, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 15-30 part, Chinese cassia tree 13-25 part, Ligusticum wallichii 16-31 part, Amomum cardamomum 14-22 part, test 19-35 part, flexuose bittercress herb and seed 18-27 part, oiltea camellia seed 18-21 part, Huang 19-25 part over sixty years of age, the blue 17-32 part of thumb, mile swertia herb 19-26 part, root of herbaceous peony 21-34 part, flos caryophylli 20-38 part, fore-telling mustard 13-21 part, testis et penis canitis 17-21 part, faenum graecum 17-31 part and HERBA EPIMEDII 19-31 part.
5. described for improving the feed of chicken immunity according to claim 1-4 any one, it is characterized in that, described Chinese medicine additive is comprised of the raw medicinal material of following ratio of weight and number: 21 parts of Radix Codonopsis, 18 parts of Chinese cassia trees, 23 parts of Ligusticum wallichiis, 18 parts of Amomum cardamomums, test 25 parts, 23 parts of flexuose bittercress herb and seeds, 19 parts of oiltea camellia seeds, 21 parts of yellow over sixty years of ages, blue 25 parts of thumb, 23 parts of mile swertia herbs, 27 parts of the root of herbaceous peonys, 29 parts of flos caryophyllis, foretell 17 parts, mustard, 25 parts of 19 parts of testis et penis canitises, 24 parts of faenum graecums and HERBA EPIMEDIIs.
6. according to claim 1-5 any one is described, for improving the feed of chicken immunity, it is characterized in that, the preparation method of described Chinese medicine additive comprises the following steps:
The first step, according to ratio of weight and number weighting raw materials material, be ground into powder after mixing;
Second step, the first step is obtained to powder add in cold water and to soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3～5 times of the powder quality that obtains of the first step;
The 3rd step, the filter residue that second step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtered fluid, obtain the second filtrate, identical in the quality of the water added and second step;
The 4th step, the first filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into to spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 orders～400 orders, obtain the Chinese medicine composition powder.
7. the preparation method for the feed that improves chicken immunity as described as claim 1-6 any one, is characterized in that, described preparation method comprises the following steps:
The first step, the preparation of described Chinese medicine composition additive;
Second step, feed vector is ground into to 100 orders～200 purpose powder, the Chinese medicine composition powder obtained with the 3rd step mixes, pour in the granulating disc that is placed in heeling condition, open granulating disc and make its rotation, while is evenly sprayed the starch solution of vaporific 20% concentration to the mixture in granulating disc, the weight of described starch solution is 1/5～1/10 of described mixture quality, the rotating speed of granulating disc is 50 rev/mins, preparation time is 15 minutes, the spherical particle feed that to be prepared into diameter be 0.8 millimeter;
The 3rd step, the spherical particle feed that second step is obtained, spread on the mesh-belt drier with the portable stainless steel guipure of multilayer, heat drying 10 minutes, the import air temperature of heating is 150 degree, the outlet air temperature is 80 degree, obtains dry feed granules.
8. the preparation method for the feed that improves chicken immunity according to claim 7, is characterized in that, the described first step comprises: according to ratio of weight and number weighting raw materials material, be ground into powder after mixing; Above-mentioned steps is obtained to powder and add in cold water and to soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, and obtains the first filtrate, and the dregs of a decoction are standby, and the quality of the water added is 3～5 times of the powder quality that obtains; The filter residue that above-mentioned steps filter is obtained adds in cold water again, with slow fire boiling 2～4 times, decocts 1 hour～2 hours at every turn, filters and merges filtered fluid, obtains the second filtrate, and the quality of the water added and above-mentioned steps add quality identical of water; The first filtrate and the second filtrate are merged, and reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into to spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 orders～400 orders, obtain the Chinese medicine composition powder.
9. one kind for improving the Chinese medicine composition of chicken immunity, it is characterized in that, described Chinese medicine composition is comprised of the raw medicinal material of following ratio of weight and number: Radix Codonopsis 10-34 part, Chinese cassia tree 10-30 part, Ligusticum wallichii 10-36 part, Amomum cardamomum 10-28 part, test 10-45 part, flexuose bittercress herb and seed 13-32 part, oiltea camellia seed 13-29 part, Huang 16-28 part over sixty years of age, the blue 8-45 part of thumb, mile swertia herb 13-40 part, root of herbaceous peony 13-45 part, flos caryophylli 17-40 part, fore-telling mustard 10-24 part, testis et penis canitis 14-23 part, faenum graecum 8-38 part and HERBA EPIMEDII 17-34 part.
10. according to claim 9ly for improving the Chinese medicine composition of chicken immunity, it is characterized in that, the preparation method of described Chinese medicine composition is as follows:
The first step, according to ratio of weight and number weighting raw materials material, be ground into powder after mixing;
Second step, the first step is obtained to powder add in cold water and to soak 24 hours～36 hours, with slow fire boiling, decocting time is 2 hours～3 hours, and decoction liquor is filtered, obtain the first filtrate, the quality of the water added is 3～5 times of the powder quality that obtains of the first step;
The 3rd step, the filter residue that second step filter is obtained add in cold water again, with slow fire boiling 2～4 times, decoct 1 hour～2 hours at every turn, filter and merge filtered fluid, obtain the second filtrate, identical in the quality of the water added and second step;
The 4th step, the first filtrate and the second filtrate are merged, reduced pressure concentration, except desolventizing, obtains and gets dry extract, dry cream is put into to spray dryer dry, guarantee that EAT is at 170 ℃～190 ℃, 60 ℃～80 ℃ of leaving air temps, be ground into subsequently 200 orders～400 orders, obtain the Chinese medicine composition powder.
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Effective date of registration: 20161226 Address after: 261100 Shandong Province, Weifang city Hanting District Zhu Village Street Beach Community Patentee after: Weifang new hope six and feed Technology Co., Ltd. Address before: 266061 Shandong city of Qingdao province Chengyang Jihongtan Street Green Industrial Park Patentee before: Shandong Newhope Liuhe Group Co.,Ltd. |
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Effective date of registration: 20170124 Address after: 261100 Shandong Province, Weifang city Hanting District Zhu Village Street Beach Community Patentee after: Weifang new hope six and feed Technology Co., Ltd. Address before: 266061 Shandong city of Qingdao province Chengyang Jihongtan Street Green Industrial Park Patentee before: Shandong New Hope Liuhe Group Co., Ltd. |