CN104667135B - A kind of pharmaceutical composition, health products and preparation method - Google Patents

A kind of pharmaceutical composition, health products and preparation method Download PDF

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CN104667135B
CN104667135B CN201510124136.8A CN201510124136A CN104667135B CN 104667135 B CN104667135 B CN 104667135B CN 201510124136 A CN201510124136 A CN 201510124136A CN 104667135 B CN104667135 B CN 104667135B
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freeze
fructus amomi
parts
haematococcus
aloe
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CN104667135A (en
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刘平怀
何沂飞
罗宁
张玲
李昂
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Hainan University
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Abstract

The present invention relates to drug field, more particularly to a kind of pharmaceutical composition, health products and preparation method.The pharmaceutical composition and health products include haematococcus pluvialis, immunity-regulating cell strengthen immunity, understand that interior free yl is anti-oxidant and alleviate body fatigue, be monarch drug in a prescription, play primary health-care effect；Aloe extract relieving constipation by purgation, clearing liver-fire, have and understand that free radical is anti-oxidant, mitigate ultraviolet radiation injury, strengthen immune antitumor action, be ministerial drug, act what is complemented each other；Coordinate fructus amomi, Noni puree, dampness elimination appetizing, qi-regulating temperature spleen, improve the nourishing opsonic action such as insomnia, inflammation, pain, endocrinopathy, immune system, the two is respectively adjutant, makes medicine, plays a part of to consolidate and promote the efficacy of a drug.Aloe is the product of the bitter cold impairment of the spleen, and its warming middle-JIAO and strengthening the spleen is taken with fructus amomi, suppresses that its is cold, in order to avoid injure healthy tendency.Proved through animal function test, anti-oxidant gentle physical fatigue effect can be effectively played, be good herbal mixture health food.

Description

A kind of pharmaceutical composition, health products and preparation method
Technical field
The present invention relates to drug field, more particularly to a kind of pharmaceutical composition, health products and preparation method.
Background technology
Into 21 century, chronic disease, which turns into, perplexs the main reason for healthy, and sub-health population proportion gradually increases.It is more next More people starts to advocate naturally, focusing on health care and health.But some chronic diseases such as oxidative damage, hypoimmunity and muscle power Fatiguability etc., which turns into, perplexs the main reason for healthy.
Inferior health is a kind of critical condition, the people in sub-health state, although without clear and definite disease, essence occurs The decline of refreshing vigor, adaptability and respond, if this state can not be corrected timely, it is very easy to cause the heart Body disease.Inferior health refers to non-sick unhealthy status, and this is a kind of inferior health status, is the shape between health and disease State, therefore have the appellation of " secondary health ", " third state ", " intermediateness ", " state of vacillating ", " gray states " etc. again, China is general All over referred to as " sub-health state ".
The reason for causing sub-health state, is a lot, except due to energy, muscle power overdraw, human-body biological week caused by fatigue Outside the interim factor such as low tide period, body illness, the reason for mental disease is also one extremely important.If human body is in sub- strong Easily ill during health state, body and mind does not feel well, to learning, living and physical and mental health has undesirable effect, it is impossible to play very well Physical and psychological potentiality.Therefore sub-health state should be paid attention to, taking effective measures makes defective or obstacle body and mind work( It can be improved, strengthened or be compensated, be lapsed to from sub-health state to health status.To prevent and eliminating sub-health state, should do Good following aspect：
1st, modest movement." exercise makes one strong ", university student should adhere to suitable activity description and manner, Huo Zhexuan The body building for the decline aging for participating in every energy each organ of delaying human body is selected, is such as swum.2nd, the appropriate nutrition of general equilibrium. Human body has a degree to the demand of various materials, and Excess free enthalpy will run counter to desire, high sugar, high salt, food rich in fat Long-term excessive feed, especially saturated fat excessive acid can cause sub-health state.Therefore balanced appropriate nutrition is to safeguard to be good for One of basic means of health.3rd, keep mental health.The negativity such as long-term direct stimulation and pressure and long-term oppressive indignation Mood, and cause the factor of the one side of inferior health.Keep good phychology, it is optimistic it is open-minded, rouse oneself go-aheadism, be Prevent and treat the spiritual basis of inferior health.Hobby can be suitably cultivated, such as reads, listen music, picture of practising handwriting to be beneficial to physically and mentally healthy Activity.4th, self health consciousness is improved.Relinquished bad habits in daily life and have a liking for such as smoking, excessive drinking, partial eclipse, accomplish to drink Eating has section, and daily life has often, not overworked, improves self health consciousness, feels that constructing first that control inferior health occurs prevents Line.It is to prevent and treat the physical basis of sub-health state to overcome bad life style.5th, intervene in good time.Take chemoprophylaxis, health products The intervening measure that conditioning, physical training are combined, exotic diseases invasion and attack can be resisted, immunity can be improved, improve inferior health State.
But the health products effect for improving sub-health state at present is undesirable, therefore it provides a kind of have anti-oxidant and alleviate The health products of physical fatigue function have important practical significance.
The content of the invention
In view of this, the present invention provides a kind of pharmaceutical composition, health products and preparation method.Demonstrate,proved through animal function test It is bright, anti-oxidant gentle physical fatigue effect can be effectively played.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The present invention provides a kind of pharmaceutical composition, including aloe, haematococcus, fructus amomi and Nuo Li.
Aloe bitter, cold in nature, Return liver, stomach, large intestine channel,《Book on Chinese herbal medicine is new again》Say：" irascibility is controlled, town liver wind, clear away heart-fire heat, Xie Xin It is tired, slake thirst and help produce saliva, hearing-improing and eyesight improving, the tooth that disappears swells, and solves fiery poison." haematococcus pluvialis are volvocales, haematococcus section, it is acknowledged as nature The best biology of natural astaxanthin is produced in boundary, it removes 6000 times that the ability of free radical is ascorbic effect, Zao Zhong In the traditional traditional Chinese medical science of state, food and medicine from " Sheng Nong's herbal classic " to " Compendium of Materia Medica " rich in antioxidant and safety are always all Regard as top grade.Fructus amomi acrid flavour is warm-natured, returns spleen, stomach, kidney channel,《Bencao Jingshu》Say：" smell pungent-warm and it is fragrant, fragrance enters spleen, Xin Neng Moisten kidney, therefore to open the key medicine of taste, and the certified products of middle gas, if simultaneous kidney deficiency, gas does not return member, and non-this is that guide is not good." promise it is beautiful for bar Ji Tian genus rubias section plant.Its fruit Noni fruit can be used to treat a variety of diseases, and such as diabetes, hypertension, heart is uncomfortable, aches Bitterly, depression and indigestion etc..The locals for living in South Pacific Ocean island country has more than 2,000 with Noni fruit health care The history in year, and it is described as：" after plant, the favor of God ".
In some specific embodiments of the present invention, in terms of mass parts, pharmaceutical composition includes 2~3 parts of aloe, red ball 12~16 parts of algae, 15~20 parts of fructus amomi and beautiful 20~24 parts of promise.
In some specific embodiments of the present invention, pharmaceutical composition includes aloe extract 2-3 parts, haematococcus pluvialis Broken wall algae powder 12-16 parts, Fructus Amomi 15-20 parts, Noni puree freeze-dried powder 20-24 parts.
In other specific embodiments of the present invention, pharmaceutical composition includes 3 parts of aloe extract, haematococcus pluvialis 16 parts of broken wall algae powder, 20 parts of Fructus Amomi, 24 parts of Noni puree freeze-dried powder.
In some specific embodiments of the present invention, the preparation method of aloe extract described in pharmaceutical composition is： Chinese aloe leaf is taken, is mixed after pretreatment with cellulase and pectase, digests, filtrate is collected by filtration, is concentrated, freeze-drying.
In other specific embodiments of the present invention, the preparation method cellulase of the aloe extract or fruit The mass ratio of glue enzyme and Chinese aloe leaf is 0.01:100.
In other specific embodiments of the present invention, the enzyme of the preparation method cellulase of the aloe extract Work is 10000U/g.
In other specific embodiments of the present invention, the enzyme activity of pectase in the preparation method of the aloe extract For 30000U/g.
In other specific embodiments of the present invention, the condition digested in the preparation method of the aloe extract is Water is added, in ultrasonic power 600W, temperature 70 C, ultrasonic extraction 45min under the conditions of extract solution pH 8.9；Preferably, water Addition is 5 times of aloe leaf quality.
Concentrated in other specific embodiments of the present invention, in the preparation method of the aloe extract is specially to take It is 1.06-1.1 that 60 DEG C of filtrate, which is concentrated under reduced pressure into density,.
In other specific embodiments of the present invention, the side that is freeze-dried in the preparation method of the aloe extract Method is that filtrate concentrate all freezes after aloe is extracted, and vacuumizes, in vacuum in -40 DEG C of -50 DEG C of freezing 60-100min To freeze 24-48h under conditions of 10-15Pa.
In some specific embodiments of the present invention, the preparation of the algae powder of haematococcus pluvialis broken wall described in pharmaceutical composition Method is：Haematococcus pluvialis are taken to be concentrated, freeze-drying through supersonic wave wall breaking.
It is ultrasonic in the preparation method of the haematococcus pluvialis broken wall algae powder in other specific embodiments of the present invention Ripple broken wall is specially that 70% EtOH Sonicate ripple extracts 30min, liquid ratio (mass ratio) 10 in 10~30 DEG C:1.
In other specific embodiments of the present invention, concentrated in the preparation method of the haematococcus pluvialis broken wall algae powder Specially 50 DEG C are concentrated under reduced pressure into no alcohol taste.
In other specific embodiments of the present invention, freezed in the preparation method of the haematococcus pluvialis broken wall algae powder Dry method is in -40 DEG C of -50 DEG C of freezing 60-100min, treats that haematococcus pluvialis broken wall concentrate all freezes, vacuumizes, 24-48h is freezed under conditions of vacuum is 10-15Pa.
In some specific embodiments of the present invention, the preparation method of Fructus Amomi described in pharmaceutical composition is to take sun Fructus amomi is dried.
Dried in other specific embodiments of the present invention, in the preparation method of the Fructus Amomi is in temperature 50 DEG C -60 DEG C, under conditions of vacuum -0.1Mpa, dry 3-4h.
In some specific embodiments of the present invention, the preparation method of Noni puree freeze-dried powder described in pharmaceutical composition To take Noni fruit squeezing to obtain Noni puree, freeze-drying.
In other specific embodiments of the present invention, it is freeze-dried in the preparation method of the Noni puree freeze-dried powder Method be in -40 DEG C -50 DEG C freezing 60-100min, treat that Noni puree is all freezed, vacuumize, be 10-15Pa in vacuum Under conditions of freeze 24-48h.
Present invention also offers aforementioned pharmaceutical compositions prepare anti-oxidant and/or fatigue-relieving health products, medicine or Application in food.
Present invention also offers the preparation method of aforementioned pharmaceutical compositions, comprise the following steps：
Step 1：Chinese aloe leaf is taken, is mixed after pretreatment with cellulase and pectase, digests, filtrate is collected by filtration, is concentrated, Freeze-drying, obtain aloe extract；
Step 2：Haematococcus is taken to concentrate through supersonic wave wall breaking, freeze-drying, obtain haematococcus broken wall algae powder；
Step 3：Take fructus amomi to dry, obtain dried fructus amomi；
Step 4：Noni fruit squeezing is taken to obtain Noni puree, freeze-drying obtains Noni puree freeze-dried powder；
Step 5：Take aloe extract made from step 1, haematococcus broken wall algae powder made from step 2, done made from step 3 Noni puree freeze-dried powder made from fructus amomi, step 4 after dry mixes after crushing, and crushes again；
Step 1 is to step 4 sequencing regardless of time.
In other specific embodiments of the present invention, fiber in the preparation method of aloe extract described in step 1 The mass ratio of plain enzyme or pectase and Chinese aloe leaf is 0.01:100.
In other specific embodiments of the present invention, fiber in the preparation method of aloe extract described in step 1 The enzyme activity of plain enzyme is 10000U/g.
In other specific embodiments of the present invention, pectin in the preparation method of aloe extract described in step 1 The enzyme activity of enzyme is 30000U/g.
In other specific embodiments of the present invention, digested in the preparation method of aloe extract described in step 1 Condition to add water, in ultrasonic power 600W, temperature 70 C, ultrasonic extraction 45min under the conditions of extract solution pH 8.9；As excellent Choosing, the addition of water are 5 times of aloe leaf quality.
In other specific embodiments of the present invention, concentrated in the preparation method of aloe extract described in step 1 It is 1.06-1.1 specially to take 60 DEG C of filtrate to be concentrated under reduced pressure into density.
In other specific embodiments of the present invention, freezed in the preparation method of aloe extract described in step 1 Dry method is that filtrate concentrate all freezes after aloe is extracted, and vacuumizes in -40 DEG C of -50 DEG C of freezing 60-100min, 24-48h is freezed under conditions of vacuum is 10-15Pa.
In other specific embodiments of the present invention, the preparation side of the algae powder of haematococcus pluvialis broken wall described in step 2 Supersonic wave wall breaking is specially that 70% EtOH Sonicate ripple extracts 30min, liquid ratio (mass ratio) 10 in 10~30 DEG C in method:1.
In other specific embodiments of the present invention, the preparation side of the algae powder of haematococcus pluvialis broken wall described in step 2 Concentration is specially concentrated under reduced pressure into no alcohol taste for 50 DEG C in method.
In other specific embodiments of the present invention, the preparation side of the algae powder of haematococcus pluvialis broken wall described in step 2 The method being freeze-dried in method is in -40 DEG C of -50 DEG C of freezing 60-100min, treats that haematococcus pluvialis broken wall concentrate all freezes, Vacuumize, 24-48h is freezed under conditions of vacuum is 10-15Pa.
The present invention other specific embodiments in, in the preparation method of Fructus Amomi described in step 3 drying be Under conditions of -60 DEG C of temperature 50 C, vacuum -0.1Mpa, 3-4h is dried.
In other specific embodiments of the present invention, in the preparation method of Noni puree freeze-dried powder described in step 4 The method of freeze-drying is in -40 DEG C of -50 DEG C of freezing 60-100min, treats that Noni puree is all freezed, vacuumizes, in vacuum To freeze 24-48h under conditions of 10-15Pa.
In other specific embodiments of the present invention, step 5 is specially to take aloe extract made from step 1, step Haematococcus broken wall algae powder made from rapid 2, dried fructus amomi made from step 3, Noni puree freeze-dried powder difference made from step 4 40-80 mesh is broken into, 100-150 mesh is ground into after mixing.
In some specific embodiments of the present invention, haematococcus described in the preparation method of aforementioned pharmaceutical compositions is rain Raw haematococcus；The fructus amomi is Fructus Amomi.
Present invention also offers a kind of anti-oxidant and/or fatigue-relieving health products, including aforementioned pharmaceutical compositions and medicine Acceptable auxiliary material on.
In some specific embodiments of the present invention, pharmaceutically acceptable auxiliary material described in above-mentioned health products includes wheat One or both of bud dextrin, microcrystalline cellulose.
In other specific embodiments of the present invention, in terms of mass parts, above-mentioned health products include aloe 2-3 parts, red Ball algae 12-16 parts, fructus amomi 15-20 parts, the beautiful 20-24 parts of promise, maltodextrin 20-30 parts, microcrystalline cellulose 20-25 parts.
In other specific embodiments of the present invention, in terms of mass parts, above-mentioned health products include aloe extract powder 2-3 parts, haematococcus pluvialis extraction thing 12-16 parts, Fructus Amomi 15-20 parts, Noni puree freeze-dried powder 20-24 parts, malt Dextrin 20-30 parts, microcrystalline cellulose 20-25 parts.
Present invention also offers the production technology of above-mentioned health products, comprise the following steps：The extraction of aloe gel；Rain life is red Ball algae broken wall；Fructus Amomi is dried；The pretreatment of Noni puree；Aloe gel extract and Noni puree freeze-drying；Aloe Extract, haematococcus pluvialis broken wall algae powder, Fructus Amomi and Noni puree freeze-dried powder crush respectively, and press its component and parts by weight Addition auxiliary material maltodextrin and microcrystalline cellulose are uniformly mixed to get finished product.
Present invention also offers a kind of preparation method of health products anti-oxidant and/or fatigue-relieving as described above, its feature It is, comprises the following steps：
Step 1：Chinese aloe leaf is taken, is mixed after pretreatment with cellulase and pectase, digests, filtrate is collected by filtration, is concentrated； Obtain aloe extract；
Step 2：Haematococcus is taken to concentrate, dry through supersonic wave wall breaking；Obtain haematococcus broken wall algae powder；
Step 3：Take fructus amomi to dry, obtain dried fructus amomi；
Step 4：Noni fruit squeezing is taken to obtain Noni puree, freeze-drying obtains Noni puree freeze-dried powder；
Step 5：Take aloe extract made from step 1, haematococcus broken wall algae powder made from step 2, done made from step 3 After Noni puree freeze-dried powder made from fructus amomi, step 4 after dry mixes with maltodextrin and microcrystalline cellulose, freeze-drying, powder It is broken；
Step 1 is to step 4 sequencing regardless of time.
In other specific embodiments of the present invention, fiber in the preparation method of aloe extract described in step 1 The mass ratio of plain enzyme or pectase and Chinese aloe leaf is 0.01:100.
In other specific embodiments of the present invention, fiber in the preparation method of aloe extract described in step 1 The enzyme activity of plain enzyme is 10000U/g.
In other specific embodiments of the present invention, pectin in the preparation method of aloe extract described in step 1 The enzyme activity of enzyme is 30000U/g.
In other specific embodiments of the present invention, digested in the preparation method of aloe extract described in step 1 Condition to add water, in ultrasonic power 600W, temperature 70 C, ultrasonic extraction 45min under the conditions of extract solution pH 8.9；As excellent Choosing, the addition of water are 5 times of aloe leaf quality.
In other specific embodiments of the present invention, concentrated in the preparation method of aloe extract described in step 1 It is 1.06-1.1 specially to take 60 DEG C of filtrate to be concentrated under reduced pressure into density.
In other specific embodiments of the present invention, freezed in the preparation method of aloe extract described in step 1 Dry method is that filtrate concentrate all freezes after aloe is extracted, and vacuumizes in -40 DEG C of -50 DEG C of freezing 60-100min, 24-48h is freezed under conditions of vacuum is 10-15Pa.
In other specific embodiments of the present invention, the preparation side of the algae powder of haematococcus pluvialis broken wall described in step 2 Supersonic wave wall breaking is specially that 70% EtOH Sonicate ripple extracts 30min, liquid ratio (mass ratio) 10 in 10~30 DEG C in method:1.
In other specific embodiments of the present invention, the preparation side of the algae powder of haematococcus pluvialis broken wall described in step 2 Concentration is specially concentrated under reduced pressure into no alcohol taste for 50 DEG C in method.
In other specific embodiments of the present invention, the preparation side of the algae powder of haematococcus pluvialis broken wall described in step 2 The method being freeze-dried in method is in -40 DEG C of -50 DEG C of freezing 60-100min, treats that haematococcus pluvialis broken wall concentrate all freezes, Vacuumize, 24-48h is freezed under conditions of vacuum is 10-15Pa.
The present invention other specific embodiments in, in the preparation method of Fructus Amomi described in step 3 drying be Under conditions of -60 DEG C of temperature 50 C, vacuum -0.1Mpa, 3-4h is dried.
In other specific embodiments of the present invention, in the preparation method of Noni puree freeze-dried powder described in step 4 The method of freeze-drying is in -40 DEG C of -50 DEG C of freezing 60-100min, treats that Noni puree is all freezed, vacuumizes, in vacuum To freeze 24-48h under conditions of 10-15Pa.
In other specific embodiments of the present invention, step 5 is specially to take aloe extract made from step 1, step Haematococcus broken wall algae powder made from rapid 2, dried fructus amomi made from step 3, Noni puree freeze-dried powder difference made from step 4 40-80 mesh is broken into, 100-150 mesh is ground into after mixing.
In other specific embodiments of the present invention, step 6 specially takes the original crushed after the mixing that step 5 obtains The water that the raw material gross mass 20%-30% is added in material is made into suitable soft, using the side of screen cloth concussion rubbing and pressure sieving Wet grain, sieve mesh number 20,40 mesh, finally, by the wet granular in 60-70 DEG C of drying, packing are made in formula.
In some specific embodiments of the present invention, the preparation method bag of anti-oxidant and/or fatigue-relieving health products Include following steps：
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.06-1.1.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, -60 DEG C of temperature 50 C, vacuum -0.1MPa, drying time 3- 4 hours；
(4) the pretreatment of Noni puree：Nuo Li is taken, Noni puree is made；Mass ratio according to Nuo Li and maltodextrin is (20-24)：(20-30) adds maltodextrin；
In some embodiments of the invention, quality is changed into the 1/24 of original weight after Noni puree is freeze-dried, by pulp dry powder： Maltodextrin=1：1 adds dextrin, and therefore, after conversion, the mass ratio of maltodextrin and Noni puree is 24：1；
In some embodiments of the invention, the quality of Noni puree is 48kg.
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -40 DEG C -50 DEG C, and cooling time is 60-100 minutes, treats that sample all freezes, vacuumizes, vacuum 10-15Pa, Cooling time is 24-48 hours.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 40-80 mesh；
(7) by (6) raw material that step crushes by aloe extract powder 2-3 parts of component and parts by weight, haematococcus pluvialis broken wall Extract 12-16 parts, Fructus Amomi 15-20 parts, Noni puree freeze-dried powder 20-24 parts, microcrystalline cellulose 20-25 parts are carried out uniformly 100-150 mesh is ground into after mixing.
(8) pelletize：The water that raw material gross mass 20%-30% is added in the raw material crushed (7) step is mixed after is made into Suitable soft, wet grain, sieve mesh number 20,40 mesh, finally, by described wet are made by the way of screen cloth concussion rubbing and pressure sieving Grain dries in 60-70 DEG C, is distributed into bag.
The invention provides a kind of pharmaceutical composition, including aloe, haematococcus, fructus amomi and Nuo Li.The present invention formula be The demand of anti-oxidant gentle physical fatigue health food is arisen at the historic moment according to market, around function above, passed in traditional Chinese medicine Blanket insurance is good under theoretical direction, for easily being influenceed and physical fatiguability crowd by oxidation, in strict accordance with《Health food Management Office Method》On the relevant regulations of raw material selection, the selection aloe vera gel extract rainy available for new resource food register, The Chinese medicine fructus amomi of raw haematococcus algae powder, Noni puree and integration of drinking and medicinal herbs, to ensure the security of product；This product has removing toxic substances Anti-inflammatory, strengthening vital QI to eliminate pathogenic factors, dampness elimination appetizing, warming spleen and stopping diarrha etc. act on, and modern medicine supports it to have anti-oxidant gentle physical fatigue Effect, to ensure the validity of product.
There are the anti-oxidant and health products of function of physical fatigue alleviation present invention also offers a kind of, with integration of drinking and medicinal herbs class Medicinal material and new resource food are raw material, through modernization of Chinese medicine Standard processing protocol, obtain efficient novel healthy food, can grow Phase takes.
From the angle of theory of traditional Chinese medical science, this formula reuses haematococcus pluvialis, and it acts on glutamine transaminage, consumption putrescine resists Radiation, immunocyte strengthen immunity is adjusted, understand that interior free yl is anti-oxidant and alleviate body fatigue, be monarch drug in a prescription, play primary health care Effect；Aloe extract relieving constipation by purgation, clearing liver-fire, have and understand that free radical is anti-oxidant, mitigate ultraviolet radiation injury, enhancing Immune antitumor action, is ministerial drug, acts what is complemented each other；Coordinate fructus amomi, Noni puree, dampness elimination appetizing, qi-regulating temperature spleen, change The nourishing opsonic action such as kind insomnia, inflammation, pain, endocrinopathy, immune system, more preferably, the two is respectively to help to health-care effect Medicine, make medicine, play a part of to consolidate and promote the efficacy of a drug.Aloe is the product of the bitter cold impairment of the spleen, and its warming middle-JIAO and strengthening the spleen is taken with fructus amomi, and it is cold to suppress it Property, in order to avoid injure healthy tendency.Complete square compatibility 5 is reasonable, giving consideration to both the incidental and fundamental, and is proved through animal function test, can effectively play it is anti-oxidant and Alleviate physical fatigue effect, be good herbal mixture health food.
This product prescription is the reasonable compatibility under the thought guidance of Traditional Chinese health health, while emphasizing " to nurse one's health ", is focused on Nutrition, the marrow of " support to be better than and control ", comprehensively embodiment tcm health preserving.Start with from human body constitution, there is provided the nutrition of general equilibrium, it is selected Chinese medicine, according to modern crafts, it is contemplated that appropriate drink more water can promote human metabolism and manufactured granule electuary, have Anti-oxidant and function of physical fatigue alleviation, instant-drink, sub-health population is facilitated, easily received.Its production technology is simple Controllable, cost is low.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing There is the required accompanying drawing used in technology description to be briefly described.
Fig. 1 show prepared in the embodiment of the present invention 1 have the anti-oxidant and health products electuary of function of physical fatigue alleviation and its The process chart of production technology.
Embodiment
The invention discloses a kind of pharmaceutical composition, health products and preparation method, those skilled in the art can use for reference this Literary content, it is suitably modified technological parameter realization.In particular, all similar replacements and change are to art technology It is it will be apparent that they are considered as being included in the present invention for personnel.The method of the present invention and application are by preferable Embodiment is described, related personnel substantially can not depart from present invention, in spirit and scope to side as described herein Method and application are modified or suitably changed with combining, to realize and using the technology of the present invention.
Raw materials used and reagent can be purchased by market in pharmaceutical composition provided by the invention, health products and preparation method .
With reference to embodiment, the present invention is expanded on further：
Embodiment 1
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.06.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, 55 DEG C, vacuum -0.1MPa of temperature, drying time 3 hours；
(4) the pretreatment of Noni puree：290kg promises are beautiful, are squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li and wheat The mass ratio of bud dextrin is 20：20 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -40 DEG C, and cooling time is 60 minutes, treats that sample all freezes, vacuumizes, vacuum 10Pa, cooling time 24 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 40 mesh；
(7) (6) raw material that step crushes is carried by 2 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 12 parts of thing, 15 parts of Fructus Amomi, 20 parts of Noni puree freeze-dried powder, 20 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 100 mesh.
(8) pelletize：The aloe extract 0.2kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.2kg, Fructus Amomi 1.5kg and the water system of Noni puree freeze-dried powder 2.0kg, 2.0kg microcrystalline cellulose and raw material gross mass 20% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 60 DEG C, is distributed into bag.
Embodiment 2
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.08.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, temperature 50 C, vacuum -0.1MPa, drying time 3 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 20：24 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -40 DEG C, and cooling time is 60 minutes, treats that sample all freezes, vacuumizes, vacuum 10Pa, cooling time 24 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 40 mesh；
(7) (6) raw material that step crushes is carried by 2 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 13 parts of thing, 16 parts of Fructus Amomi, 21 parts of Noni puree freeze-dried powder, 21 parts of microcrystalline cellulose is taken to carry out being ground into 100 after uniformly mixing Mesh.
(8) pelletize：The aloe extract 0.2kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.3kg, Fructus Amomi 1.6kg and the water system of Noni puree freeze-dried powder 2.1kg, 2.1kg microcrystalline cellulose and raw material gross mass 20% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 60 DEG C, is distributed into bag.
Embodiment 3
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.08.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, temperature 60 C, vacuum -0.1MPa, drying time 4 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 20：30 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -45 DEG C, and cooling time is 80 minutes, treats that sample all freezes, vacuumizes, vacuum 12Pa, cooling time 36 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 60 mesh；
(7) (6) raw material that step crushes is carried by 2 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 14 parts of thing, 17 parts of Fructus Amomi, 22 parts of Noni puree freeze-dried powder, 22 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 100 mesh.
(8) pelletize：The aloe extract 0.2kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.4kg, Fructus Amomi 1.7kg and the water system of Noni puree freeze-dried powder 2.2kg, 2.2kg microcrystalline cellulose and raw material gross mass 25% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 65 DEG C, is distributed into bag.
Embodiment 4
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.09.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, 55 DEG C, vacuum -0.1MPa of temperature, drying time 3.5 is small When；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 22：20 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -48 DEG C, and cooling time is 90 minutes, treats that sample all freezes, vacuumizes, vacuum 13Pa, cooling time 48 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 80 mesh；
(7) (6) raw material that step crushes is carried by 2 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 15 parts of thing, 18 parts of Fructus Amomi, 23 parts of Noni puree freeze-dried powder, 23 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 150 mesh.
(8) pelletize：The aloe extract 0.2kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.5kg, Fructus Amomi 1.8kg and the water system of Noni puree freeze-dried powder 2.3kg, 2.3kg microcrystalline cellulose and raw material gross mass 30% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 70 DEG C, is distributed into bag.
Embodiment 5
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.1.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, temperature 60 C, vacuum -0.1MPa, drying time 4 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 22：24 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is 50 DEG C, and cooling time is 100 minutes, treats that sample all freezes, vacuumizes, vacuum 15Pa, cooling time 48 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 80 mesh；
(7) (6) raw material that step crushes is carried by 2 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 16 parts of thing, 19 parts of Fructus Amomi, 24 parts of Noni puree freeze-dried powder, 24 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 150 mesh.
(8) pelletize：The aloe extract 0.2kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.6kg, Fructus Amomi 1.9kg and the water system of Noni puree freeze-dried powder 2.4kg, 2.4kg microcrystalline cellulose and raw material gross mass 20% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 70 DEG C, is distributed into bag.
Embodiment 6
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.1.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, 58 DEG C, vacuum -0.1MPa of temperature, drying time 4 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 22：30 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -49 DEG C, and cooling time is 90 minutes, treats that sample all freezes, vacuumizes, vacuum 15Pa, cooling time 48 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 60 mesh；
(7) (6) raw material that step crushes is carried by 2 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 16 parts of thing, 20 parts of Fructus Amomi, 24 parts of Noni puree freeze-dried powder, 25 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 100 mesh.
(8) pelletize：The aloe extract 0.2kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.6kg, Fructus Amomi 2.0kg and the water system of Noni puree freeze-dried powder 2.4kg, 2.5kg microcrystalline cellulose and raw material gross mass 30% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 65 DEG C, is distributed into bag.
Embodiment 7
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.06.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, temperature 60 C, vacuum -0.1MPa, drying time 3.5 is small When；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 24：20 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -45 DEG C, and cooling time is 70 minutes, treats that sample all freezes, vacuumizes, vacuum 14Pa, cooling time 30 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 60 mesh；
(7) (6) raw material that step crushes is carried by 2 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 16 parts of thing, 20 parts of Fructus Amomi, 24 parts of Noni puree freeze-dried powder, 25 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 100 mesh.
(8) pelletize：The aloe extract 0.2kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.6kg, Fructus Amomi 2.0kg and the water system of Noni puree freeze-dried powder 2.4kg, 2.5kg microcrystalline cellulose and raw material gross mass 25% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 65 DEG C, is distributed into bag.
Embodiment 8
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.07.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, temperature 50 C, vacuum -0.1MPa, drying time 3 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 24：24 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -45 DEG C, and cooling time is 70 minutes, treats that sample all freezes, vacuumizes, vacuum 15Pa, cooling time 36 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 40 mesh；
(7) (6) raw material that step crushes is carried by 3 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 12 parts of thing, 15 parts of Fructus Amomi, 20 parts of Noni puree freeze-dried powder, 20 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 100 mesh.
(8) pelletize：The aloe extract 0.3kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.2kg, Fructus Amomi 1.5kg and the water system of Noni puree freeze-dried powder 2.0kg, 2.0kg microcrystalline cellulose and raw material gross mass 25% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 65 DEG C, is distributed into bag.
Embodiment 9
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.1.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, temperature 60 C, vacuum -0.1MPa, drying time 3 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 24：30 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -50 DEG C, and cooling time is 80 minutes, treats that sample all freezes, vacuumizes, vacuum 15Pa, cooling time 48 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 60 mesh；
(7) (6) raw material that step crushes is carried by 3 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 13 parts of thing, 16 parts of Fructus Amomi, 21 parts of Noni puree freeze-dried powder, 21 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 150 mesh.
(8) pelletize：The aloe extract 0.3kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.3kg, Fructus Amomi 1.6kg and the water system of Noni puree freeze-dried powder 2.1kg, 2.1kg microcrystalline cellulose and raw material gross mass 25% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 60 DEG C, is distributed into bag.
Embodiment 10
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.06.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, temperature 50 C, vacuum -0.1MPa, drying time 3 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 20：20 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -40 DEG C, and cooling time is 60 minutes, treats that sample all freezes, vacuumizes, vacuum 15Pa, cooling time 48 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 60 mesh；
(7) (6) raw material that step crushes is carried by 3 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 14 parts of thing, 17 parts of Fructus Amomi, 22 parts of Noni puree freeze-dried powder, 22 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 150 mesh.
(8) pelletize：The aloe extract 0.3kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.4kg, Fructus Amomi 1.7kg and the water system of Noni puree freeze-dried powder 2.2kg, 2.2kg microcrystalline cellulose and raw material gross mass 30% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 70 DEG C, is distributed into bag.
Embodiment 11
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.06.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, 55 DEG C, vacuum -0.1MPa of temperature, drying time 3 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 20：24 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -50 DEG C, and cooling time is 60 minutes, treats that sample all freezes, vacuumizes, vacuum 15Pa, cooling time 36 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 80 mesh；
(7) (6) raw material that step crushes is carried by 3 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 15 parts of thing, 18 parts of Fructus Amomi, 23 parts of Noni puree freeze-dried powder, 23 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 150 mesh.
(8) pelletize：The aloe extract 0.3kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.5kg, Fructus Amomi 1.8kg and the water system of Noni puree freeze-dried powder 2.3kg, 2.3kg microcrystalline cellulose and raw material gross mass 30% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 60 DEG C, is distributed into bag.
Embodiment 12
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.06.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, temperature 50 C, vacuum -0.1MPa, drying time 4 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 20：30 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -50 DEG C, and cooling time is 80 minutes, treats that sample all freezes, vacuumizes, vacuum 12Pa, cooling time 36 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 40 mesh；
(7) (6) raw material that step crushes is carried by 3 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 16 parts of thing, 19 parts of Fructus Amomi, 24 parts of Noni puree freeze-dried powder, 24 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 100 mesh.
(8) pelletize：The aloe extract 0.3kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.6kg, Fructus Amomi 1.9kg and the water system of Noni puree freeze-dried powder 2.4kg, 2.4kg microcrystalline cellulose and raw material gross mass 20% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 60 DEG C, is distributed into bag.
Embodiment 13
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.08.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, 55 DEG C, vacuum -0.1MPa of temperature, drying time 4 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 24：20 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -45 DEG C, and cooling time is 80 minutes, treats that sample all freezes, vacuumizes, vacuum 12Pa, cooling time 36 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 60 mesh；
(7) (6) raw material that step crushes is carried by 3 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 16 parts of thing, 20 parts of Fructus Amomi, 24 parts of Noni puree freeze-dried powder, 25 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 100 mesh.
(8) pelletize：The aloe extract 0.3kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.6kg, Fructus Amomi 2.0kg and the water system of Noni puree freeze-dried powder 2.4kg, 2.5kg microcrystalline cellulose and raw material gross mass 20% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 65 DEG C, is distributed into bag.
Embodiment 14
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.08.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, 55 DEG C, vacuum -0.1MPa of temperature, drying time 4 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 24：34 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -40 DEG C, and cooling time is 80 minutes, treats that sample all freezes, vacuumizes, vacuum 15Pa, cooling time 36 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 60 mesh；
(7) (6) raw material that step crushes is carried by 3 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 16 parts of thing, 20 parts of Fructus Amomi, 24 parts of Noni puree freeze-dried powder, 25 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 150 mesh.
(8) pelletize：The aloe extract 0.3kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.6kg, Fructus Amomi 2.0kg and the water system of Noni puree freeze-dried powder 2.4kg, 2.5kg microcrystalline cellulose and raw material gross mass 30% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 65 DEG C, is distributed into bag.
Embodiment 15
(1) the extraction of aloe gel：Fresh leaf of aloe is taken, cleaning, peeling, mashing, adds 0.01% cellulase and pectase (enzymatic activity is respectively 10000U/g, 30000U/g), with the deionized water of 5 times of amounts, in ultrasonic power 600W, temperature 70 C, carry Ultrasonic extraction 45min under the conditions of liquid pH 8.9 is taken, filtration, merging filtrate, obtains Aqueous extracts, 60 DEG C of extract solution is concentrated under reduced pressure into close Spend for 1.06.
(2) haematococcus pluvialis algae powder broken wall：70% EtOH Sonicate ripple normal temperature extracts 30min, liquid ratio 10:1,50 DEG C of decompression It is concentrated into no alcohol taste；
(3) Fructus Amomi is positioned in vacuum drying chamber, temperature 60 C, vacuum -0.1MPa, drying time 3 hours；
(4) the pretreatment of Noni puree：Take 290kg promises beautiful, squeezed after fermentation and 48kg Noni purees are made, according to Nuo Li with The mass ratio of maltodextrin is 24：30 add maltodextrin, the excipient as step of freeze drying；
(5) it is freeze-dried：With vacuum freeze drier, (1), (2) and (4) pretreated aloe extract, the rain life by step Haematococcus broken wall algae powder and Noni puree difference sabot, are put into the household freezer of vacuum freeze drier, the center in household freezer Temperature is -50 DEG C, and cooling time is 100 minutes, treats that sample all freezes, vacuumizes, vacuum 15Pa, cooling time 36 Hour.
(6) crush：Aloe extract, haematococcus pluvialis extraction thing, Fructus Amomi and Noni puree freeze-dried powder are distinguished It is ground into 80 mesh；
(7) (6) raw material that step crushes is carried by 3 parts of aloe extract powder, the haematococcus pluvialis broken wall of component and parts by weight 16 parts of thing, 20 parts of Fructus Amomi, 24 parts of Noni puree freeze-dried powder, 20 parts of microcrystalline cellulose is taken be ground into after uniformly mixing 100 mesh.
(8) pelletize：The aloe extract 0.3kg that is crushed (7) step is mixed after, haematococcus pluvialis extraction thing 1.6kg, Fructus Amomi 2.0kg and the water system of Noni puree freeze-dried powder 2.4kg, 2.0kg microcrystalline cellulose and raw material gross mass 20% Into suitable soft, wet grain is made by the way of screen cloth concussion rubbing and pressure sieving, sieve mesh number 20,40 mesh finally, will be described wet Particle dries in 60 DEG C, is distributed into bag.
16 anti-oxidant zoopery of embodiment
According to Ministry of Health of the People's Republic of China《Health food is examined and assessment technique specification》(2003 editions) anti-oxidant work( Can evaluation method progress.
(1) given the test agent
Complex health care product particle prepared by embodiment 1, is red brown solid.Coming-of-Age Day dose recommended doses are 5.35g/ 60kg·bw。
(2) experimental animal and raising
Cleaning grade Kunming mouse and cleaning grade SD rats, raised using barrier level Animal House, raise room temperature 20~25 DEG C, humidity 55~65%, illumination 12h/d.Since raising the 4th day gavage, by random group forming criterion divide 892mg/kgbw groups, 1783mg/kgbw groups, 2686mg/kgbw groups and 2052mg/kgbw (are respectively equivalent to recommend day to take recommended doses 10 times, 20 times, 30 times and 23 times, respectively low dose group, middle dose group, high dose group and preferred dose group) and negative control Group, positive controls, every group 15.Experimental group is filled to feminine gender with the sample gavage of corresponding dosage according to group with isometric distilled water Stomach.Once a day, continuous gavage 30 days.By mouse fasting 12h, eyeball takes blood, is centrifuged under conditions of 8000r/min, 4 DEG C 5min, take serum Cord blood.Detect GSH-Px vigor, CAT vigor and MDA contents.
(3) internal antioxidation activity evaluation result
Influence of the health-care product particle to antioxidation activity in Mice Body is as shown in table 1.The result of GSH-Px vigor shows, five The energy value of individual dosage group is above the energy value highest of negative control group, wherein preferred dose group, is 141.33 ± 5.12U/ mg.CAT vigor results show that each experimental group is all remarkably higher than negative control group group (P<0.05), preferred dose group vigor highest, For 16.47 ± 0.61U/mg, the not notable (P of gap of low middle high three dosage groups>0.05), but preferred dose group is significantly higher than it His group.MDA content results show that the MDA contents of each experimental group are substantially less than negative control group group, the MDA of positive controls Content is minimum, is 12.19 ± 1.98U/mg, and 46.5% is reduced than blank group, and preferred dose group effect is close, and MDA is reduced 42.0%.Comprehensive analysis, each experimental result are the positive, show that health-care product particle has interior antioxidation action.
Antioxidant Indexes result in the body of table 1
* represent experimental group with blank group data variance significantly (P ＜ 0.05).
The health products that the anti-oxidant zoopery for the health products that embodiment 2 is prepared to embodiment 15 is prepared with embodiment 1 Effect is close, no significant difference (P ＞ 0.05).
Summary test result indicates that, health products provided by the invention can significantly increase oxidation resistance (P ＜ 0.05)。
Embodiment 17 alleviates physical fatigue zoopery
According to Ministry of Health of the People's Republic of China《Health food is examined and assessment technique specification》Function of health food is commented Basic demand in valency to function of physical fatigue alleviation is tested.
(1) given the test agent
Complex health care product particle prepared by embodiment 1, is red brown solid.Coming-of-Age Day dose recommended doses are 5.35g/ 60kg·bw。
(2) experimental animal
ICR male mices, body weight 18-22g, raised using barrier level Animal House, raise 20~25 DEG C of room temperature, humidity 55 ~65%, illumination 12h/d.
(3) dosage choice
Animal is bought back, and basal feed is fed 3 days, divides 892mg/kgbw groups, 1783mg/kgbw by random group forming criterion Group, 2686mg/kgbw groups and 2230mg/kgbw (be respectively equivalent to recommend 10 times that take recommended doses day, 20 times, 30 Times and 25 times, respectively low dose group, middle dose group, high dose group and preferred dose group) and negative control group and positive control Group.Experimental group is with the sample gavage of corresponding dosage, and negative control group is with isometric distilled water gavage.Once a day, continuous gavage 30 days.
(4) influence of the health products to the mice burden swimming time
The health products high dose 2686mg/kgbw dosage group mice burden swimming times are considerably longer than negative control group (P< 0.05).Higher dosage group improves a lot preferred dose group 2230mg/kgbw again, and is higher than positive controls.Specifically it is shown in Table 2。
(5) influence of the health products to the mouse pole-climbing time
As shown in table 2, health products are middle and high and preferred dose 1783,2686,2230mg/kgbw dosage group mouse pole-climbings Time is considerably longer than negative control group (P<0.05), the pole-climbing time is gradually incremented by.
(6) to sum up, this experiment uses male ICR mouse, and the health products connect by 10,20,30 and 25 times of human body recommended dose Continuous gavage 30 days, the results showed that the preferred dose group 2230mg/kgbw group mice burden swimming times are considerably longer than negative control Group (P<0.05), and it is better than positive controls.Middle and high and preferred dose 1783,2686,2230mg/kgbw group mouse pole-climbings Time is considerably longer than negative control group (P<0.05), and high dose group and preferred dose group are better than positive controls.According to evaluation Standard, this health-care product particle have the function that to alleviate physical fatigue.
Influence of the health products of table 2 to the mice burden swimming time
* represent experimental group with blank group data variance significantly (P ＜ 0.05).
The guarantor alleviated physical fatigue zoopery and prepared with embodiment 1 for the health products that embodiment 2 is prepared to embodiment 15 The effect of strong product close, no significant difference (P ＞ 0.05).
Summary test result indicates that, health products provided by the invention can significantly alleviate physical fatigue (P ＜ 0.05).
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (10)

1. a kind of pharmaceutical composition, it is characterised in that be made up of aloe, haematococcus, fructus amomi and Nuo Li.
2. pharmaceutical composition according to claim 1, it is characterised in that in terms of mass parts, by 2 ~ 3 parts of aloe, haematococcus 12 ~ 16 parts, 15 ~ 20 parts of fructus amomi and beautiful 20 ~ 24 parts of compositions of promise.
3. pharmaceutical composition according to claim 1 or 2, it is characterised in that in terms of mass parts, by aloe extract 2-3 Part, haematococcus pluvialis broken wall algae powder 12-16 parts, Fructus Amomi 15-20 parts, Noni puree freeze-dried powder 20-24 parts composition.
4. pharmaceutical composition according to claim 3, it is characterised in that the preparation method of the aloe extract is：Take Chinese aloe leaf, mixed after pretreatment with cellulase and pectase, digest, filtrate is collected by filtration, concentrated, freeze-drying；
The preparation method of the haematococcus pluvialis broken wall algae powder is：Take haematococcus pluvialis dry through supersonic wave wall breaking, concentration, freezing It is dry；
The preparation method of the Fructus Amomi is to take Fructus Amomi to dry；
The preparation method of the Noni puree freeze-dried powder is freeze-dried to take Noni fruit squeezing to obtain Noni puree.
5. the pharmaceutical composition according to any one of Claims 1-4 is preparing anti-oxidant and/or fatigue-relieving health care Application in product, medicine or food.
6. the preparation method of the pharmaceutical composition according to any one of Claims 1-4, it is characterised in that including following step Suddenly：
Step 1：Chinese aloe leaf is taken, is mixed after pretreatment with cellulase and pectase, digests, filtrate is collected by filtration, is concentrated, freezing Dry, obtain aloe extract；
Step 2：Haematococcus is taken to concentrate through supersonic wave wall breaking, freeze-drying, obtain haematococcus broken wall algae powder；
Step 3：Take fructus amomi to dry, obtain dried fructus amomi；
Step 4：Noni fruit squeezing is taken to obtain Noni puree, freeze-drying obtains Noni puree freeze-dried powder；
Step 5：After taking aloe extract made from step 1, haematococcus broken wall algae powder made from step 2, being dried made from step 3 Fructus amomi, Noni puree freeze-dried powder made from step 4 mixed after crushing, crush again；
Step 1 is to step 4 sequencing regardless of time.
7. preparation method according to claim 6, it is characterised in that the haematococcus is haematococcus pluvialis；The fructus amomi For Fructus Amomi.
8. a kind of anti-oxidant and/or fatigue-relieving health products, it is characterised in that including as described in any one of Claims 1-4 Pharmaceutical composition and pharmaceutically acceptable auxiliary material.
9. health products according to claim 8, it is characterised in that the pharmaceutically acceptable auxiliary material is pasted including malt One or both of essence, microcrystalline cellulose.
10. a kind of preparation method of anti-oxidant and/or fatigue-relieving health products as claimed in claim 8 or 9, its feature exist In comprising the following steps：
Step 1：Chinese aloe leaf is taken, is mixed after pretreatment with cellulase and pectase, digests, filtrate is collected by filtration, is concentrated, freezing Dry, obtain aloe extract；
Step 2：Haematococcus is taken to concentrate through supersonic wave wall breaking, freeze-drying, obtain haematococcus broken wall algae powder；
Step 3：Take fructus amomi to dry, obtain dried fructus amomi；
Step 4：Noni fruit squeezing is taken to obtain Noni puree, freeze-drying obtains Noni puree freeze-dried powder；
Step 5：After taking aloe extract made from step 1, haematococcus broken wall algae powder made from step 2, being dried made from step 3 Fructus amomi, Noni puree freeze-dried powder difference flour made from step 4, after being mixed with maltodextrin and microcrystalline cellulose, then wheat-middlings It is broken；
Step 6：The material after step 5 crushing is taken to be mixed with water, softwood processed, granulation；
Step 1 is to step 4 sequencing regardless of time.
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