CN106852468B - Composition containing moringa oleifera leaf extract, and preparation method, preparation and application thereof - Google Patents
Composition containing moringa oleifera leaf extract, and preparation method, preparation and application thereof Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/746—Morinda
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a composition containing a moringa oleifera leaf extract, and a preparation method, a preparation and an application thereof, wherein the composition comprises the following raw materials in percentage by weight: 30-80 parts of moringa leaf extract, 5-25 parts of emblic leafflower powder, 5-25 parts of noni powder and 1-15 parts of aloe extract. The composition has obvious effects of expelling toxin, relaxing bowels, supplementing calcium, sobering up, protecting liver and enhancing immunity, adopts materials with functions of clearing heat, sobering up, protecting liver and resisting oxidation to optimize the formula, and can supplement calcium, enhance immunity, protect liver and accelerate metabolism while treating constipation.
Description
Technical Field
The invention belongs to the technical field of healthy product preparation, and particularly relates to a composition containing a moringa oleifera leaf extract, and a preparation method, a preparation and application thereof.
Background
Due to the accelerated pace of life, increased stress and bad lifestyle habits, excessive accumulation of toxins in the body can lead to constipation. The effects of clearing intestines and expelling toxins are already hot topics, constipation is a natural enemy of modern people and interferes with normal life of people, excessive toxins caused by constipation also affect the health of the people, poor skin is caused, breath is not fresh, and the daily life of people is greatly affected. Many people today are plagued by constipation, especially women and the elderly. With the increasingly wide interpersonal interaction, alcohol is used as an unnecessary medium, and accidents and liver diseases caused by alcohol drinking are increasing. Urban white-collar women and old people are high-incidence people with calcium loss at the same time, and the problem that how to supplement calcium, sober up and protect liver while treating constipation is the current research is also the problem.
At present, a plurality of products for treating or improving constipation, supplementing calcium and sobering up in the market have poor effect, single function, need of improving various discomfort of the body, need of taking a plurality of products, and have the disadvantages of temporary solution, permanent solution and even great side effect. Therefore, it is necessary to research and develop a product which has the functions of improving constipation, supplementing calcium, sobering up and protecting liver and the like, and is convenient to take.
Disclosure of Invention
The invention aims to provide a composition containing the moringa oleifera leaf extract, a preparation method of the composition containing the moringa oleifera leaf extract, a preparation of the composition containing the moringa oleifera leaf extract and an application of the composition containing the moringa oleifera leaf extract.
The first purpose of the invention is realized by the following raw materials in parts by weight: 30-80 parts of moringa leaf extract, 5-25 parts of emblic leafflower powder, 5-25 parts of noni powder and 1-15 parts of aloe extract.
The second purpose of the invention is realized by the following steps that the raw materials are weighed according to the parts by weight and put into a wet mixing granulator, and after the raw materials are mixed for 25-35 minutes, the weight ratio of the sprayed materials to alcohol is 1:0.025 percent of edible alcohol, mixing and granulating for 20-30 minutes, and discharging to obtain the composition.
The third purpose of the invention is realized by adding pharmaceutically acceptable auxiliary materials into the composition to prepare capsules, tablets, powder, granules, liquid preparations, pills and tea.
The fourth purpose of the invention is realized by the application of the composition in preparing preventive/adjuvant treatment drugs for expelling toxin and relaxing bowels, supplementing calcium drugs, sobering up and protecting liver or health-care food.
The invention has the beneficial effects that:
1. the composition has obvious effects of expelling toxin, relaxing bowels, supplementing calcium, sobering up and protecting liver, adopts an optimized formula of materials with functions of clearing heat, sobering up and protecting liver and resisting oxidation, treats constipation, simultaneously supplements calcium, protects liver, enhances immunity, accelerates metabolism, has the effects of reducing high blood pressure, high blood sugar and high blood fat, resists cancer, effectively reduces hypertension, hyperglycemia and hyperlipidemia, and has obvious anti-tumor effect.
2. The efficacy of the moringa oleifera leaf extract in the composition is as follows: has effects in lowering blood sugar, reducing blood lipid, relieving hangover, lowering blood pressure, resisting tumor, resisting oxidation, protecting liver, supplementing calcium, relaxing bowels, promoting urination, and improving sleep; the efficacy and the function of the Pu' er tea extract in the composition are as follows: reducing blood lipid, reducing weight, caring skin, lowering blood pressure, resisting arteriosclerosis, resisting tumor, invigorating stomach, killing bacteria, and resisting aging; the effect of emblic leafflower powder in the composition is as follows: has antioxidant, liver protecting, antiinflammatory, heat clearing away, blood cooling, digestion promoting, stomach invigorating, salivation promoting, and antitussive effects; the effect of noni powder in this composition: has antioxidant, myocardial cell protecting, antiinflammatory, antifatigue, hangover relieving, toxic materials clearing away, blood pressure lowering, constipation relieving, and immunity enhancing effects; the effect of aloe vera extract in this composition: the moringa oleifera leaf instant tea has the effects of sterilizing and resisting inflammation, invigorating stomach and discharging downward, strengthening heart and promoting blood circulation, resisting immunity and cancer, detoxifying and relieving pain, has good taste, can supplement calcium, sober up and protect liver, promote the production of body fluid to quench thirst, expel toxin and relieve constipation, can enhance immunity, and solves the problem of treating both symptoms and root causes of calcium supplement, liver protection, and expulsion of toxin and relieve constipation.
3. The preparation can be prepared into instant granules, so the requirements on the dissolubility, color and luster, clearness and transparency, mouthfeel, efficacy, bioavailability and the like of a finished product are higher, the raw materials of the invention adopt different pretreatment methods, the moringa leaf raw material has the effects of expelling toxin and relaxing the bowels, enhancing the immunity, containing more fibers and strong heat sensitivity, and is not beneficial to instant absorption and preparation processing, so the low-temperature percolation extraction concentration technology is adopted, and the bioavailability is favorably improved; the Pu' er tea raw material has the advantages of heat clearing, adverse qi lowering, more fibers, strong heat sensitivity, and adverse instant absorption and preparation processing, so low-temperature ultrasonic technology is adopted to extract effective components; the emblic leafflower fruit and the noni fruit are difficult to dry, and are unfavorable in aspects of processing cost, preparation processing feasibility and the like, so that the juice-squeezing spray-drying technology is adopted to extract the fine powder, thereby being beneficial to storage, preparation processing and improvement of bioavailability; aloe has effects of removing toxic substance, relaxing bowels, enhancing immunity, increasing fiber, and strong heat sensitivity, and is not beneficial to instant absorption and preparation processing, so extracting effective components by low temperature ultrasonic technology is beneficial to improving bioavailability. The process is beneficial to the beauty and flavor enhancement of the product, enhances the effects of calcium supplement, liver protection, body fluid production promotion, thirst quenching, toxin expelling and bowel relaxing, greatly improves the concentration of the effective components of the product, and has better taste and more obvious effect. The product is prepared into granules, so that the processing, taking, storing and carrying are very convenient, and conditions are created for realizing large-scale production.
4. The formula of the invention is as follows: the raw materials for expelling toxin, beautifying, clearing heat, removing toxin, supplementing calcium, relaxing bowels, protecting liver, invigorating stomach and discharging diarrhea are matched, and the processing technology is as follows: the percolation extraction technology, the low-temperature ultrasonic extraction technology, the vacuum concentration technology, the spray drying technology, the microwave drying technology, the vacuum drying technology, the wet mixing granulation technology, the fluidized drying technology, the particle subpackaging technology and other technologies which are beneficial to the efficacy advantage of the product are combined.
5. The raw materials of the invention are mutually matched and complement each other, and the formula combination principle of the invention is as follows: the raw material moringa oleifera leaf extract is a main ingredient which plays a decisive role in expelling toxin, relaxing bowels, enhancing immunity, sobering up, protecting liver and supplementing calcium, but the moringa oleifera leaf extract is high in protein and is easy to induce gout; the Pu' er tea extract has the functions of enhancing diarrhea and neutralizing uric acid, but the cold nature also easily stimulates intestinal tracts to induce enteritis, so that the emblic leafflower fruit powder and the aloe are added, the emblic leafflower fruit powder is flat in nature and has the functions of enhancing uric acid metabolism and preventing gout, the fruit acid of the emblic leafflower fruit powder can promote digestion, invigorate stomach and promote the production of body fluid, the fructose can supplement heat and vitality, the natural vitamin C and superoxide dismutase (SOD) can enhance the immunity, the emblic leafflower fruit powder not only offsets the side effect of moringa leaves, but also has the functions of expelling toxin, relaxing bowels, resisting aging, resisting cancer and inhibiting hepatitis B virus; the active enzyme in the noni powder has the functions of removing ache, fatigue, sobering up, resisting inflammation, resisting rheumatism, expelling toxin, regenerating cells, improving nerve cells, treating hemorrhoids, growing hair, treating impotence and treating infertility: prebiotics in the aloe raw material can effectively protect intestinal tracts, promote intestinal peristalsis, enhance the effect of expelling toxin and promote the absorption of the product, thus being beneficial to quick effect; the protein sugar is beneficial to increasing metabolism and mouthfeel; the cyclodextrin can prevent the product from caking and absorbing moisture, reduce the bitter taste and the peculiar smell in the ingredients and strengthen the fragrance of the product. The extract ingredients and the raw materials are directly combined to form the optimized formula of the invention.
6. The proportion of the active ingredients of the raw material of the moringa leaves is low, the direct blending not only has low active ingredients and low absorption rate but also does not show the effect, but also has difficult preparation processing, so the active ingredients need to be extracted and then blended. In order to ensure the quality, drinking water is adopted for extraction in the process, so that the maximum selective dissolution of effective components can be ensured, the low-temperature dynamic percolation continuous extraction is adopted in the technology, and the solute is immediately conveyed away after dissolution, so that the dissolution gradient of the solute in the extraction tank is increased, the extraction is more complete, and the extraction speed is higher. The active ingredients are protected from being damaged to the maximum extent by low-temperature dynamic percolation, and the taste is better and the concentration of the active ingredients is higher compared with a boiling extraction process under the condition of equivalent feeding; the Pu' er tea raw material has the functions of clearing heat and lowering adverse qi, but has low effective components, more fibers and strong heat sensitivity, and is not beneficial to instant absorption and preparation processing, so the low-temperature ultrasonic technology is adopted to extract the effective components; the fresh wild emblic leafflower fruit and the noni fruit are unfavorable for storage and difficult to dry, and are unfavorable in aspects such as processing cost, preparation processing feasibility and the like, so the method for extracting the refined powder by squeezing and drying is favorable for storage, preparation processing and improvement of bioavailability. Because the natural vitamin C in the fruit juice can be greatly reduced after being heated for too long, in order to ensure the efficacy of the product, the specific process route adopts the direct fruit juice spray drying process, so that the water in the fruit juice is instantly evaporated, solute particles are instantly taken to a cyclone powder collector by hot air to form fine powder, the particle size can reach 200-300 meshes, and compared with the processes of concentration, drying and crushing, the direct fruit juice spray drying process has short time consumption, good product quality and superfine powder level of the product particle size, and is beneficial to preparation processing and product efficacy; aloe has strong effects of removing toxic substance and removing blood stasis, but has more fiber, is not beneficial to directly processing dosage preparation, and adopts low temperature ultrasonic extraction technology in order to promote absorption, improve bioavailability and highlight product efficacy.
Detailed Description
The present invention is further illustrated by the following examples, which are not intended to be limiting in any way, and any modifications or alterations based on the teachings of the present invention are intended to fall within the scope of the present invention.
The composition containing the moringa oleifera leaf extract comprises the following raw materials in parts by weight: 30-80 parts of moringa leaf extract, 5-25 parts of emblic leafflower powder, 5-25 parts of noni powder and 1-15 parts of aloe extract.
The composition containing the moringa oleifera leaf extract comprises the following raw materials in parts by weight: 50-65 parts of moringa leaf extract, 6-11 parts of emblic leafflower powder, 6-15 parts of noni powder and 2-8 parts of aloe extract.
The composition containing the moringa oleifera leaf extract comprises the following raw materials in parts by weight: 52-62 parts of moringa leaf extract, 7-10 parts of emblic leafflower powder, 7-12 parts of noni powder and 3-6 parts of aloe extract.
The composition also comprises 2-10 parts by weight of Pu' er tea extract.
The composition also comprises 4-8 parts by weight of Pu' er tea extract.
The composition also comprises 1-8 parts by weight of proteoglycan.
The composition also comprises 2-6 parts by weight of proteoglycan.
The extraction method of the moringa oleifera leaf extract comprises the following working procedures of extraction, separation, concentration, drying and post-treatment, and specifically comprises the following steps:
1) extraction: weighing the moringa oleifera leaf raw material, putting the moringa oleifera leaf raw material into an extraction tank, adding 3-7 times of purified water, and soaking for 1-3 hours; heating the extraction tank by steam, keeping the temperature at 80-85 ℃ for extraction for 25-35 min, then keeping the temperature at 75-80 ℃ for percolation extraction, keeping the extracting solution in the extraction tank and a circulating pump for closed circulating extraction for 4-5 h, stopping circulation, and leading out liquid in the extraction tank to obtain a first extracting solution; adding hot water with the temperature of 75-80 ℃ which is 4-5 times of the feeding amount of the moringa oleifera leaf raw material into the extraction tank, keeping the extracting solution in the extraction tank and the circulating pump for closed circulation for 4-5 hours, then leading out a second extracting solution, combining the second extracting solution with the first extracting solution and uniformly mixing; discarding the moringa leaves;
2) separation: standing and precipitating the extracting solution obtained in the step 1) for 2-4 h, taking the supernatant, centrifuging and filtering at a high speed to obtain a pure moringa oleifera leaf extracting solution, and discarding the precipitate;
3) concentration: introducing the moringa oleifera leaf extracting solution obtained in the step 2) into a concentrator, vacuumizing and concentrating until the relative specific gravity is 1.15-1.2, and collecting paste;
4) and (3) drying: vacuum drying the concentrated paste obtained in the step 3) until the moisture content is 4.5-5%, and collecting to obtain moringa oleifera leaf paste;
5) and (3) post-treatment: crushing the moringa leaf paste obtained in the step 4) by using a crusher, and sieving to obtain a moringa leaf extract for later use.
The amount of the purified water in the step 1) is 6-7 times that of the purified water.
The steam heating in the step 1) is to keep the cooling water pressure of a condenser of the extraction tank at 0.3-0.4 MPa, and the steam heating pressure of the extraction tank at 0.2-0.25 MPa.
The high-speed centrifugal filtration in the step 2) is high-speed tube type centrifuge filtration, and the rotating speed is 16000-20000 r/min.
And 3) carrying out vacuum concentration in the step 3) at a temperature of 60-65 ℃ under a vacuum degree of-0.07 to-0.075 MPa.
And 4) vacuum drying in the step 4) is to uniformly lay the concentrated paste on a baking tray of a vacuum drying oven, and dry the concentrated paste under the conditions of keeping the vacuum degree of minus 0.07 to minus 0.075MPa and the temperature of 60 to 65 ℃.
The extraction method of the Pu' er tea extract comprises the working procedures of extraction, separation, concentration, drying and post-treatment, and specifically comprises the following steps:
1) extraction: weighing a Pu' er tea raw material, putting the raw material into an extraction tank, adding 3-8 times of drinking water, keeping the temperature at 10-30 ℃, and soaking for 2-3 hours; heating the extraction tank by steam, controlling the temperature to be 50-60 ℃, performing ultrasonic treatment for 0.5-1.5 h, performing closed-loop circulation on the leaching liquor for 0.5-1.5 h, repeating the ultrasonic treatment and the closed-loop circulation for 2-4 times, filtering to obtain tea liquid, and discarding tea residues;
2) separation: firstly, carrying out centrifugal filtration, naturally precipitating the tea liquid obtained in the step 1) for 3-5 hours, taking supernatant liquid, carrying out high-speed centrifugal filtration to obtain the tea liquid with poor light transmittance, and discarding the precipitate; then, filtering with a filter membrane, and filtering the centrifugally filtered tea liquid with the filter membrane, wherein the aperture of the filter membrane is 0.1-0.22 μm to obtain the tea liquid with good light transmittance;
3) concentration: vacuum concentrating the tea liquid separated in the step 2) until the specific gravity is 1.2-1.25, and collecting paste;
4) and (3) drying: carrying out microwave drying on the concentrated paste obtained in the step 3), and collecting the dried paste until the moisture content is 4-4.5% to obtain Pu' er tea paste;
5) and (3) post-treatment: crushing the Pu 'er tea paste obtained in the step 4) by using a crusher, and sieving to obtain a Pu' er tea extract for later use.
The adding amount of the drinking water in the step 1) is 6-8 times.
The filtration in the step 1) is filtration by a 100-mesh filter screen.
The high-speed centrifugal filtration in the step 2) is high-speed tube type centrifuge filtration, and the rotating speed is 16000-20000 r/min.
The pressure of the filter membrane filtration in the step 2) is kept at 0.4-0.5 MPa.
And 3) carrying out vacuum concentration in the step 3) at 50-60 ℃ under the condition of keeping the vacuum degree at-0.07 to-0.075 MPa.
The preparation method of the composition containing the moringa oleifera leaf extract comprises the following steps of weighing the raw materials in parts by weight, putting the raw materials into a wet mixing granulator, mixing for 25-35 min, and spraying a mixture of the materials and alcohol in a weight ratio of 1:0.025 percent of edible alcohol, mixing, granulating for 20-30 min, and discharging to obtain the composition.
The preparation of the composition containing the moringa oleifera leaf extract is prepared by adding pharmaceutically acceptable auxiliary materials into the composition to prepare granules, tablets, powder, capsules, liquid preparations, pills and tea.
The auxiliary material contains cyclodextrin.
The application of the composition containing the moringa oleifera leaf extract is the application of the composition in preparing medicines or health-care foods for preventing/assisting in treating toxin expelling and relaxing bowels, sobering and protecting liver and supplementing calcium.
The emblic leafflower fruit powder is emblic leafflower fruit fine powder, and the noni fruit powder is noni fruit fine powder.
The preparation method of the emblic leafflower fruit powder comprises the following steps:
1) removing rotten fruits and impurities from fresh wild phyllanthus emblica fruits, and then using a drum-type fruit washing machine, wherein the drum rotating speed is kept at 15-20 r/min, and the water spraying flow is 5-10 m3The feeding speed is kept at 8-10 kg/min, clean fresh fruits are obtained, and the water is drinking water;
2) using a fruit crusher, keeping the feeding speed at 5-8 kg/min, and crushing the cleaned fresh fruits into particles with the particle size of 2-5 mm;
3) a fruit screw press is used, the rotating speed is kept at 60-70 r/min, particles are added at a constant speed, the feeding speed is kept at 3-5 kg/min, fruit residues are discharged, and thick fruit juice flows out from the bottom through a filter screen;
4) using a centrifugal machine, keeping the drum speed at 1000-1500 rpm, adding the thick pulp juice obtained in the step 3) at a constant speed, and keeping the feeding speed at 0.2-0.5 m3Discharging separated residues in one minute to obtain clear juice;
5) the juice is sent into a conical settling tank for natural settling for 3 hours, the supernatant is filtered by a high-speed tubular centrifuge with the rotating speed of 16000-20000 r/min, clear and transparent emblic leafflower fruit juice without sediment, insoluble and suspended particles is obtained, and the sediment is discarded;
6) and (3) carrying out spray drying on the clear juice liquid obtained in the step (5), keeping the rotating speed of a high-speed centrifugal atomizer at 6000-6500 r/min, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 50-200 Pa, keeping the inlet temperature at the top of the tower at 230-240 ℃, keeping the outlet temperature at the bottom of the tower at 110-120 ℃, carrying out pulse rapping for 10 times/min, stabilizing the feeding flow of a screw pump at 80-100L/min, and continuously carrying out spray drying to obtain the phyllanthus emblica powder with the particle size of 200-300 meshes.
The preparation method of the noni powder comprises the following steps:
1) removing rotten fruits and impurities from fresh noni fruits, and then using a drum-type fruit washing machine, wherein the drum rotation speed is kept at 10-15 r/min, and the water spraying flow is 3-7 m3The feeding speed is kept at 3-5 kg/min, clean fresh fruits are obtained, and the water is drinking water;
2) a fruit spiral juicer is used, the rotating speed is kept at 50-60 rpm, particles are added at a constant speed, the feeding speed is kept at 1-3 kg/min, fruit residues are discharged, and thick fruit juice flows out from the bottom through a filter screen;
3) using a centrifugal machine, keeping the drum speed at 1000-1500 rpm, adding the thick pulp juice obtained in the step 2) at a constant speed, and keeping the feeding speed at 0.2-0.5 m3Discharging separated residues in one minute to obtain clear juice;
4) naturally precipitating the fruit juice in a conical precipitation tank for 3 hours, filtering the supernatant by a high-speed tubular centrifuge at the rotating speed of 16000-20000 r/min to obtain clear and transparent noni fruit juice without precipitate, insoluble and suspended particles, and discarding the precipitate;
5) and (3) carrying out spray drying on the clear juice liquid obtained in the step 4), keeping the rotating speed of a high-speed centrifugal atomizer at 6000-6500 r/min, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 50-200 Pa, keeping the temperature of an inlet at the top of the tower at 220-230 ℃, keeping the temperature of an outlet at the bottom of the tower at 100-110 ℃, carrying out pulse vibration for 10 times/min, stabilizing the feeding flow of a screw pump at 80-100L/min, and continuously carrying out spray drying to obtain the noni fruit powder with the granularity of 200-300 meshes.
The preparation method of the aloe extract comprises the following steps:
1) weighing aloe raw materials, putting the aloe raw materials into an extraction tank, adding 6-8 times of drinking water, keeping the temperature at 10-30 ℃, and soaking for 2-3 hours;
2) starting a condenser of the extraction tank and steam heating, performing ultrasonic treatment for 0.5-1.5 h at the temperature of 50-60 ℃ when the temperature in the extraction tank reaches 50-60 ℃, extracting the extract from the bottom of the tank, adding the extract into the top of the tank, performing closed cycle for 0.5-1.5 h, repeating the operation of ultrasonic treatment and closed cycle for 2-4 times, filtering to obtain extract, and discharging residues;
3) feeding the extracting solution into a settling tank for natural settling for 3 hours, taking supernatant, filtering by a high-speed tubular centrifuge at the rotating speed of 16000-20000 r/min to obtain the extracting solution which is free of precipitate insoluble and suspended particles and poor in light transmittance, and discarding precipitates;
4) filtering the extract filtered by the high-speed tubular centrifuge by a membrane filter with the aperture of a filter membrane of 0.1-0.22 mu m, and keeping the filtering pressure at 0.4-0.5 MPa to obtain clear and transparent aloe extract with good light transmission;
5) vacuum concentrating the extracting solution, keeping the vacuum degree at-0.07 to-0.075 MPa and the temperature of 60 to 65 ℃, concentrating until the specific gravity is 1.2 to 1.25, collecting the paste, uniformly paving the concentrated paste on a baking tray, putting the baking tray on a rotating baking rack, keeping the vacuum degree at-0.07 to-0.075 MPa and the temperature of 60 to 65 ℃, performing microwave drying, and collecting when the water content is 5 to 5.5 percent; and then crushing the dried aloe paste by using a 5.5KW universal crusher, and sieving to obtain the aloe extract with the granularity of 80-120 meshes.
Example 1
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 30 parts of moringa leaf extract, 5 parts of emblic leafflower powder, 5 parts of noni powder and 1 part of aloe extract.
Pharmaceutically acceptable auxiliary materials are added into the composition of the example 1 to prepare a liquid preparation. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 2
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 80 parts of moringa leaf extract, 25 parts of emblic leafflower powder, 25 parts of noni powder and 15 parts of aloe extract.
The composition of the example 2 is added with pharmaceutically acceptable auxiliary materials to prepare pills. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 3
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 50 parts of moringa leaf extract, 6 parts of emblic leafflower powder, 6 parts of noni powder and 2 parts of aloe extract.
The composition of example 3 is added with pharmaceutically acceptable auxiliary materials to prepare granules. The auxiliary material contains cyclodextrin. The composition can be applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 4
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 65 parts of moringa leaf extract, 11 parts of emblic leafflower powder, 15 parts of noni powder and 8 parts of aloe extract.
The composition of example 4 is added with pharmaceutically acceptable auxiliary materials to prepare tablets. The auxiliary material contains cyclodextrin. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 5
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 50 parts of moringa leaf extract, 6 parts of emblic leafflower powder, 6 parts of noni powder, 2 parts of aloe extract and 2 parts of Pu' er tea extract.
The composition of example 5 is added with pharmaceutically acceptable auxiliary materials to prepare powder. The auxiliary material contains cyclodextrin. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 6
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 60 parts of moringa leaf extract, 10 parts of emblic leafflower powder, 12 parts of noni powder, 6 parts of aloe extract and 10 parts of Pu' er tea extract.
A capsule was prepared by adding pharmaceutically acceptable excipients to the composition of example 6. The auxiliary material contains cyclodextrin. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 7
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 40 parts of moringa leaf extract, 8 parts of emblic leafflower powder, 8 parts of noni powder, 4 parts of aloe extract, 4 parts of Pu' er tea extract and 1 part of aspartame.
Pharmaceutically acceptable auxiliary materials are added into the composition of the example 7 to prepare a liquid preparation. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 8
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: the feed comprises the following raw materials in parts by weight: 70 parts of moringa leaf extract, 14 parts of emblic leafflower powder, 14 parts of noni powder, 7 parts of aloe extract, 8 parts of Pu' er tea extract and 8 parts of aspartame.
The composition of example 8 is added with pharmaceutically acceptable auxiliary materials to prepare pills. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 9
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 55 parts of moringa leaf extract, 7 parts of emblic leafflower powder, 7 parts of noni powder, 3 parts of aloe extract, 3 parts of Pu' er tea extract and 3 parts of aspartame.
The composition of example 9 is added with pharmaceutically acceptable auxiliary materials to prepare a tea preparation. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 10
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 52 parts of moringa leaf extract, 8 parts of emblic leafflower powder, 8 parts of noni powder, 6 parts of aloe extract, 4 parts of Pu' er tea extract and 4 parts of aspartame.
The composition of example 10 is added with pharmaceutically acceptable auxiliary materials to prepare granules. The auxiliary material contains cyclodextrin. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 11
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 45 parts of moringa leaf extract, 9 parts of emblic leafflower powder, 9 parts of noni powder, 9 parts of aloe extract, 9 parts of Pu' er tea extract and 7 parts of aspartame.
The composition of example 11 is added with pharmaceutically acceptable auxiliary materials to prepare tablets. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 12
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 58 parts of moringa leaf extract, 20 parts of emblic leafflower powder, 20 parts of noni powder, 13 parts of aloe extract, 5 parts of Pu' er tea extract and 5 parts of aspartame.
The composition of example 12 is added with pharmaceutically acceptable excipients to prepare a powder. The auxiliary material contains cyclodextrin. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 13
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 68 parts of moringa leaf extract, 12 parts of emblic leafflower powder, 13 parts of noni powder and 10 parts of aloe extract.
The composition of example 13 was added with pharmaceutically acceptable excipients to prepare a tea formulation. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 14
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 57 parts of moringa leaf extract, 9 parts of emblic leafflower powder, 11 parts of noni powder, 5 parts of aloe extract, 6 parts of Pu' er tea extract and 5 parts of aspartame.
The composition of example 14 is added with pharmaceutically acceptable auxiliary materials to prepare granules. The auxiliary material contains cyclodextrin. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 15
A composition containing a moringa oleifera leaf extract comprises the following raw materials in parts by weight: 62 parts of moringa leaf extract, 10 parts of emblic leafflower powder, 12 parts of noni powder, 6 parts of aloe extract and 7 parts of Pu' er tea extract.
The composition of example 15 is added with pharmaceutically acceptable auxiliary materials to prepare tablets. The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 16
1) Weighing: 62 parts of moringa leaf extract, 7 parts of emblic leafflower powder, 8 parts of noni powder, 6 parts of aloe extract, 5 parts of Pu' er tea extract and 2 parts of glycoprotein for later use;
2) mixing: putting the materials weighed in the step 1) into a wet mixing granulator, mixing for 30 minutes, and spraying a mixture of the materials and alcohol in a weight ratio of 1: 0.025% edible alcohol, and the mixer-granulator was run for 24 minutes to obtain the composition.
The extraction method of the moringa oleifera leaf extract comprises the following steps:
1) extraction: weighing moringa leaf raw materials, putting into an extraction tank, adding 6 times of drinking water, and soaking for 2 hours; keeping the cooling water pressure of a condenser of the extraction tank at 0.3MPa, keeping the steam heating pressure of the extraction tank at 0.2MPa, keeping the temperature at 80 ℃ for boiling and extracting for 25 minutes when the temperature in the extraction tank reaches 85 ℃ and the water vapor condensate flows back into the extraction tank, then closing the steam of the extraction tank, and keeping the temperature in the extraction tank at 75 ℃; percolating, keeping the extractive solution in extraction tank and circulating pump, circulating for 4 hr, stopping circulation, and completely pumping out the liquid in extraction tank to obtain first extractive solution; adding hot water with the temperature of 75 ℃ which is 4 times of the feeding amount of the moringa leaf raw materials into an extraction tank, after the hot water is added, keeping the extracting solution in the extraction tank and a circulating pump for closed circulation for 4 hours, completely pumping out the liquid in the extraction tank to obtain a second extracting solution, and discharging moringa leaf residues;
2) centrifugal filtration: starting a circulating pump to mix circularly for 25 minutes, and uniformly mixing the first extracting solution and the second extracting solution; naturally precipitating the uniformly mixed extracting solution for 2 hours, filtering the supernatant by a high-speed tubular centrifuge with the rotating speed of 16000r/min to obtain clear and transparent moringa leaf extracting solution without precipitate insoluble and suspended particulate matters, and discarding the precipitate;
3) concentrating and drying: pumping the moringa oleifera leaf extracting solution into a concentrator, heating with hot water at the temperature of 90 ℃, starting vacuum concentration, keeping the vacuum degree at-0.07 MPa and the temperature of 60 ℃, concentrating until the specific gravity is 1.15, collecting paste, uniformly paving the concentrated paste on a baking tray of a vacuum drying oven, placing the baking tray on the baking tray, keeping the vacuum degree at-0.07 MPa and the temperature of 60 ℃, performing vacuum drying, and collecting the dried paste until the moisture is 4.5%; then crushing the dried moringa leaf paste by using a crusher, and sieving to obtain a moringa leaf extract with the granularity of 80 meshes.
The extraction method of the Pu' er tea extract comprises the following steps:
1) extraction: weighing Pu' er tea raw materials, putting into an extraction tank, adding 6 times of drinking water, keeping at 10 ℃, and soaking for 2 hours; starting a condenser of the extraction tank to cool water and steam-heat a jacket of the extraction tank, controlling the temperature of the extraction tank to 50 ℃ and carrying out ultrasonic treatment for 0.5h, then carrying out closed-loop circulation on the extract for 0.5h, repeating the ultrasonic treatment and the closed-loop circulation for 2 times, filtering by a 100-mesh filter screen to obtain tea liquid, and discharging tea residues;
2) and (3) filtering: firstly, carrying out centrifugal filtration, naturally precipitating the tea liquid obtained in the step (1) for 3 hours, taking supernatant, and filtering the supernatant by a high-speed tubular centrifuge at the rotating speed of 16000r/min to obtain the tea liquid without precipitate, insoluble and suspended particles and poor light transmittance, and discarding the precipitated protein and impurities; filtering with filter membrane, filtering the centrifugally filtered tea solution with a membrane filter with filter membrane aperture of 0.1 μm, and maintaining the filtering pressure at 0.4MPa to obtain clear and transparent tea solution with good light transmittance;
3) concentrating and drying: vacuum concentrating the tea liquid obtained in the step (2), keeping the vacuum degree at-0.07 MPa and the temperature at 50 ℃, concentrating until the specific gravity is 1.2, collecting the paste, uniformly paving the concentrated paste on a baking tray, placing the baking tray on a rotating baking rack, carrying out microwave drying under the conditions of keeping the vacuum degree at-0.075 MPa and the temperature at 50 ℃, and collecting the dried tea liquid when the water content is 4%; then crushing the dried tea paste by a crusher, and sieving to obtain the Pu' er tea extract with the granularity of 80 meshes.
The preparation method of the composition comprises the steps of weighing the raw materials according to the parts by weight, putting the raw materials into a wet mixing granulator, mixing for 25 minutes, and spraying a mixture of the raw materials and alcohol according to a weight ratio of 1: 0.025% edible alcohol, mixing, granulating for 20 min, and discharging to obtain the composition.
The composition obtained in example 16 is added with pharmaceutically acceptable auxiliary materials to prepare tablets. The auxiliary materials contain 10 parts of cyclodextrin (the same as the weighed raw materials in parts by weight).
The composition obtained in example 16 is used for preparing drugs or health foods for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 17
1) Weighing: 63 parts of moringa leaf extract, 7 parts of emblic leafflower powder, 9 parts of noni powder, 3 parts of aloe extract, 4 parts of Pu' er tea extract and 3 parts of aspartame for later use;
2) mixing: putting the materials weighed in the step 1) into a wet mixing granulator, mixing for 33 minutes, and spraying a mixture of the materials and alcohol in a weight ratio of 1: 0.025% edible alcohol, and the mixer-granulator was run for 25 minutes to obtain the composition.
The extraction method of the moringa oleifera leaf extract comprises the following steps:
1) extraction: weighing moringa leaf raw materials, putting into an extraction tank, adding 6.5 times of drinking water, and soaking for 2.5 hours; keeping the cooling water pressure of a condenser of the extraction tank at 0.35MPa, keeping the steam heating pressure of the extraction tank at 0.225MPa, keeping the temperature at 82 ℃ for boiling and extracting for 30 minutes when the temperature in the extraction tank reaches 85 ℃ and the water vapor condensate reflows to the tank, then closing the steam of the extraction tank, and keeping the temperature in the tank at 77 ℃; percolating, keeping the extractive solution in extraction tank and circulating pump, circulating for 4.5 hr, stopping circulation, and completely pumping out the liquid in extraction tank to obtain first extractive solution; adding hot water at 78 deg.C, which is 4.5 times of the amount of raw Moringa oleifera leaf material, into the extraction tank, keeping the extractive solution in the extraction tank and circulating pump for closed circulation for 4.5 hr, draining off all the liquid in the extraction tank to obtain second extractive solution, and discharging Moringa oleifera leaf residue;
2) centrifugal filtration: starting a circulating pump to mix circularly for 30 minutes, and uniformly mixing the first extracting solution and the second extracting solution; naturally precipitating the uniformly mixed extracting solution for 3 hours, taking supernatant, filtering by a high-speed tubular centrifuge at the rotating speed of 18000r/min to obtain clear and transparent moringa oleifera leaf extracting solution without precipitate insoluble and suspended particles, and discarding the precipitate;
3) concentrating and drying: pumping the moringa oleifera leaf extracting solution into a concentrator, heating the moringa oleifera leaf extracting solution by hot water at the temperature of 92 ℃, starting vacuum concentration, keeping the vacuum degree at-0.0725 MPa and the temperature of 62 ℃, concentrating the moringa oleifera leaf extracting solution until the specific gravity is 1.17, collecting paste, uniformly laying the concentrated paste on a baking tray of a vacuum drying oven, putting the baking tray on the baking tray, carrying out vacuum drying under the conditions of keeping the vacuum degree at-0.0725 MPa and the temperature of 62 ℃, and collecting the paste when the moisture is 4.25%; then crushing the dried moringa leaf paste by using a crusher, and sieving to obtain the moringa leaf extract with the granularity of 100 meshes.
The extraction method of the Pu' er tea extract comprises the following steps:
1) extraction: weighing Pu' er tea raw materials, putting into an extraction tank, adding 7 times of drinking water, keeping the temperature at 20 ℃, and soaking for 2.5 hours; starting a condenser of the extraction tank to cool water and steam-heat a jacket of the extraction tank, controlling the temperature of 55 ℃ in the extraction tank to perform ultrasonic treatment for 1h, performing closed-loop circulation on the leaching solution for 1h, repeating the ultrasonic treatment and the closed-loop circulation for 3 times, filtering by a 100-mesh filter screen to obtain tea liquid, and discharging tea residues;
2) and (3) filtering: firstly, carrying out centrifugal filtration, naturally precipitating the tea liquid obtained in the step (1) for 4 hours, taking supernatant, and filtering the supernatant by a high-speed tubular centrifuge at the rotating speed of 18000r/min to obtain the tea liquid without precipitate, insoluble and suspended particles and poor light transmittance, and discarding the precipitated protein and impurities; filtering with filter membrane, filtering the centrifugally filtered tea solution with a membrane filter with filter membrane aperture of 0.2 μm, and maintaining the filtering pressure at 0.45MPa to obtain clear and transparent tea solution with good light transmittance;
3) concentrating and drying: vacuum concentrating the tea liquid obtained in the step (2), keeping the vacuum degree at-0.0725 MPa and the temperature at 55 ℃, concentrating until the specific gravity is 1.225, collecting the paste, uniformly paving the concentrated paste on a baking tray, placing the baking tray on a rotating baking tray, carrying out microwave drying under the conditions of keeping the vacuum degree at-0.0775 MPa and the temperature at 55 ℃, and collecting the dried tea liquid until the moisture is 4.25%; then crushing the dried tea paste by a crusher, and sieving to obtain the Pu' er tea extract with the granularity of 100 meshes.
The preparation method of the composition comprises the steps of weighing the raw materials according to the parts by weight, putting the raw materials into a wet mixing granulator, mixing for 30 minutes, and spraying a mixture of the raw materials and alcohol according to a weight ratio of 1: 0.025% edible alcohol, mixing, granulating for 25 min, and discharging to obtain the composition.
The composition prepared in example 17 was added with pharmaceutically acceptable excipients to prepare a powder.
The composition prepared in example 17 is used for preparing drugs or health foods for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 18
1) Weighing: 65 parts of moringa leaf extract, 6 parts of emblic leafflower powder, 7 parts of noni powder, 3 parts of aloe extract, 8 parts of Pu' er tea extract and 2 parts of glycoprotein for later use;
2) mixing: putting the materials weighed in the step 1) into a wet mixing granulator, mixing for 35 minutes, and spraying a mixture of the materials and alcohol in a weight ratio of 1: 0.025% edible alcohol, and the mixer-granulator was run for 27 minutes to obtain the composition.
The extraction method of the moringa oleifera leaf extract comprises the following steps:
1) extraction: weighing moringa leaf raw materials, putting into an extraction tank, adding 7 times of drinking water, and soaking for 3 hours; keeping the cooling water pressure of a condenser of the extraction tank at 0.4MPa, keeping the steam heating pressure of the extraction tank at 0.25MPa, keeping the temperature at 85 ℃ when the temperature in the extraction tank reaches 85 ℃ and the steam condensate flows back into the extraction tank, boiling and extracting for 35 minutes, then closing the steam of the extraction tank, and keeping the temperature in the extraction tank at 80 ℃; percolating, keeping the extractive solution in extraction tank and circulating pump, circulating for 5 hr, stopping circulation, and completely pumping out the liquid in extraction tank to obtain first extractive solution; adding hot water at 80 ℃ which is 5 times of the feeding amount of the moringa oleifera leaf raw material into an extraction tank, keeping the extracting solution in the extraction tank and a circulating pump for closed circulation for 5 hours after the hot water is added, completely pumping out the liquid in the extraction tank to obtain a second extracting solution, and discharging moringa oleifera leaf residues;
2) centrifugal filtration: starting a circulating pump to mix circularly for 35 minutes, and uniformly mixing the first extracting solution and the second extracting solution; naturally precipitating the uniformly mixed extracting solution for 4 hours, taking supernatant, filtering by a high-speed tubular centrifuge with the rotating speed of 20000r/min to obtain clear and transparent moringa oleifera leaf extracting solution without precipitate insoluble and suspended particulate matters, and discarding the precipitate;
3) concentrating and drying: pumping the moringa oleifera leaf extracting solution into a concentrator, heating the concentrate by using hot water at the temperature of 95 ℃, starting vacuum concentration, keeping the vacuum degree at-0.075 MPa and the temperature of 65 ℃, concentrating the concentrate to the specific gravity of 1.2, collecting paste, uniformly paving the concentrated paste on a baking tray of a vacuum drying oven, placing the baking tray on the baking tray, keeping the vacuum degree at-0.075 MPa and the temperature of 65 ℃, carrying out vacuum drying, and collecting the paste when the water content is 5%; then crushing the dried moringa leaf paste by using a crusher, and sieving to obtain a moringa leaf extract with the granularity of 120 meshes.
The extraction method of the Pu' er tea extract comprises the following steps:
1) extraction: weighing Pu' er tea raw materials, putting into an extraction tank, adding 8 times of drinking water, maintaining the temperature at 30 ℃, and soaking for 3 hours; starting a condenser of the extraction tank to cool water and steam-heat a jacket of the extraction tank, controlling the temperature of the extraction tank to 60 ℃ and carrying out ultrasonic treatment for 1.5h, then carrying out closed-loop circulation on the extract for 1.5h, repeating the ultrasonic treatment and the closed-loop circulation for 4 times, filtering by a 100-mesh filter screen to obtain tea liquid, and discharging tea residues;
2) and (3) filtering: firstly, carrying out centrifugal filtration, naturally precipitating the tea liquid obtained in the step (1) for 5 hours, taking supernatant, and filtering the supernatant by a high-speed tubular centrifuge with the rotating speed of 20000r/min to obtain the tea liquid without precipitate insoluble and suspended particles and poor light transmittance, and discarding the precipitated protein and impurities; filtering with filter membrane, filtering the centrifugally filtered tea solution with a membrane filter with filter membrane aperture of 0.22 μm, and maintaining the filtering pressure at 0.5MPa to obtain clear and transparent tea solution with good light transmittance;
3) concentrating and drying: vacuum concentrating the tea liquid obtained in the step (2), keeping the vacuum degree at-0.075 MPa and the temperature of 60 ℃, concentrating until the specific gravity is 1.25, collecting the paste, uniformly paving the concentrated paste on a baking tray, placing the baking tray on a rotating baking tray, carrying out microwave drying under the conditions of keeping the vacuum degree at-0.08 MPa and the temperature of 60 ℃, and collecting the dried tea liquid until the water content is 4.5%; then crushing the dried tea paste by a crusher, and sieving to obtain the Pu' er tea extract with the granularity of 120 meshes.
The preparation method of the composition comprises the steps of weighing the raw materials according to the parts by weight, putting the raw materials into a wet mixing granulator, mixing for 35 minutes, and spraying the mixture of the materials and alcohol according to the weight ratio of 1: 0.025% edible alcohol, mixing, granulating for 30min, and discharging to obtain the composition.
A capsule was prepared by adding pharmaceutically acceptable excipients to the composition prepared in example 18. The auxiliary material contains 9 parts of cyclodextrin (the weight parts are the same as the weight parts of the raw materials).
The composition is applied to preparation of drugs or health-care food for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protection and calcium supplement.
Example 19
Extracting the moringa oleifera leaf extract:
1) weighing moringa leaf raw materials, putting into an extraction tank, adding 6 times of drinking water, and soaking for 2 hours;
2) starting a condenser cooling water of the extraction tank and steam heating of a jacket of the extraction tank, keeping the cooling water pressure of the condenser at 0.3MPa, keeping the steam heating pressure of the extraction tank at 0.2MPa, keeping the temperature at 80 ℃ for boiling and extracting for 30 minutes when the temperature in the extraction tank reaches 85 ℃ and the steam condensate flows back into the extraction tank, then closing the steam of the extraction tank, and keeping the temperature in the extraction tank at 75 ℃;
3) first percolation circulation: the infusion valve between the full-open extraction tank and the external circulation concentrator is opened, so that the extracting solution in the extraction tank enters the stainless steel circulating pump through the outlet valve, the circulating pump is started to suck the liquid of the extracting solution into the extraction tank again for continuous circulation, the valve of the extracting solution entering the circulating pump is kept fully opened, the outlet of the circulating pump is communicated with the valve in the extraction tank to be fully opened, the pipeline valve communicated with the extracting solution storage tank is closed, the liquid is sucked into the extraction tank through the circulating pump continuously, the whole process is dynamic, the dissolving speed of the active ingredients of the moringa oleifera is increased, and the extracting solution is circulated in a; stopping circulation, closing a valve leading to the extraction tank from an outlet of the circulating pump, completely opening a pipeline valve leading to the extracting solution storage tank, and completely pumping out liquid in the extraction tank;
4) and (3) second percolation circulation: closing a pipeline valve leading to an extracting solution storage tank and an extracting tank liquid discharging valve, fully opening a valve leading to the extracting tank at a circulating pump outlet, fully opening a hot water tank to enter the circulating pump valve, adding hot water with the temperature of 75 ℃ which is 4 times of the feeding amount of the moringa oleifera leaf raw material into the extracting storage tank, repeating the first percolation circulation operation in the step (3) after the hot water is added, completely draining the liquid in the extracting tank, and discharging moringa oleifera leaf residues;
5) uniformly mixing the first and second extracting solutions in the extracting solution storage tank, fully opening the extracting solution storage tank, introducing the fully opened extracting solution storage tank into a circulating pump valve, introducing an outlet of the fully opened circulating pump into the extracting solution storage tank valve, starting the circulating pump, circularly mixing for 30 minutes, and stopping the pump;
6) feeding the extract into a precipitation tank for natural precipitation for 3 hours, filtering the supernatant by a high-speed tubular centrifuge at the rotating speed of 16000r/min to obtain clear and transparent moringa oleifera leaf extract without precipitate insoluble and suspended particulate matters, and discarding the precipitate;
7) pumping the extracting solution in the extracting solution storage tank into a jacket vacuum concentrator, heating with hot water at 90 ℃ in a hot water tank, starting vacuum concentration, keeping the vacuum degree at-0.07 MPa and the temperature at 60 ℃, concentrating to the specific gravity of 1.15, collecting paste, uniformly paving the concentrated paste on a baking tray of a vacuum drying oven, placing the baking tray on a baking rack, carrying out vacuum drying under the conditions of keeping the vacuum degree at-0.07 MPa and the temperature at 60 ℃, and collecting the dried paste until the moisture is 4.5%; then crushing the dried moringa leaf paste by using a crusher, and sieving to obtain a moringa leaf extract with the granularity of 80 meshes.
Extraction of Pu' er tea extract:
1) weighing Pu' er tea raw materials, putting into an extraction tank, adding 6 times of drinking water, keeping at 10 ℃, and soaking for 2 hours;
2) starting a condenser of the extraction tank to cool water and steam-heat a jacket of the extraction tank, controlling the temperature of the extraction tank to 50 ℃ and carrying out ultrasonic treatment for 0.5h, then extracting the extract from the bottom of the extraction tank, adding the extract into the top of the extraction tank for 0.5h in a closed cycle, repeating the ultrasonic treatment and the closed cycle for 2 times, filtering the extract by a 100-mesh filter screen to obtain tea liquid, and discharging tea residues;
3) feeding the tea liquid into a settling tank for natural settling for 4 hours, taking supernatant, filtering by a high-speed tubular centrifuge at the rotating speed of 16000r/min to obtain tea liquid which is free of insoluble and suspended particles and poor in light transmittance, and discarding the settled protein and impurities;
4) filtering the tea liquid filtered by the high-speed tubular centrifuge by a membrane filter with the aperture of a filter membrane of 0.1 mu m, and keeping the filtering pressure at 0.4MPa to obtain clear and transparent tea liquid with good light transmittance;
5) vacuum concentrating the extracted tea liquid, keeping vacuum degree at-0.07 MPa and 50 deg.C, concentrating to specific gravity of 1.2, collecting paste, spreading the concentrated paste on a baking tray, placing the baking tray on a rotary baking rack, performing microwave drying at-0.075 MPa and 50 deg.C, drying to water content of 4%, and collecting; then crushing the dried tea paste by using a 5.5KW universal crusher, and sieving to obtain the Pu' er tea extract with the granularity of 80 meshes.
Preparing emblic leafflower fruit powder:
1) mixing wild plantsRemoving rotten fruit and impurities from fresh fructus Phyllanthi, and washing with a drum-type fruit washing machine at a drum rotation speed of 15 rpm and a water spray flow of 5m3The feeding speed is kept at 8 kg/min, clean fresh fruits are obtained, and the water is drinking water;
2) using a fruit crusher, keeping the feeding speed at 5 kg/min, and crushing the cleaned fresh fruits into particles with the particle size of 2 mm;
3) a fruit screw press is used, the rotating speed is kept at 60 revolutions per minute, particles are added at a constant speed, the feeding speed is kept at 3 kilograms per minute, fruit residues are discharged, and thick fruit juice flows out from the bottom through a filter screen;
4) using a centrifuge, keeping the rotating drum speed at 1000 rpm, adding the thick syrup juice obtained in the step 3) at a constant speed, and keeping the feeding speed at 0.2m3Discharging separated residues in one minute to obtain clear juice;
5) delivering the fruit juice into a conical precipitation tank for natural precipitation for 3 hours, filtering supernatant by a high-speed tubular centrifuge with the rotating speed of 16000r/min to obtain clear and transparent phyllanthus emblica fruit juice without precipitate insoluble and suspended particulate matters, and discarding the precipitate;
6) and (3) carrying out spray drying on the clear juice liquid obtained in the step (5), keeping the rotating speed of a high-speed centrifugal atomizer at 6000 rpm, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 50Pa, keeping the inlet temperature at the top of the tower at 230 ℃, keeping the outlet temperature at the bottom of the tower at 110 ℃, carrying out pulse rapping for 10 times/min, stabilizing the feeding flow of a screw pump at 80L/min, and continuously carrying out spray drying to obtain the phyllanthus emblica powder with the granularity of 200 meshes.
Preparing noni powder:
1) removing rotten fruit and impurities from fresh noni fruit, and washing with a drum-type fruit washing machine at a drum rotation speed of 10 rpm and a water spray flow of 3m3H, keeping the feeding speed at 3 kilograms per minute to obtain clean fresh fruits, wherein the water is drinking water;
2) using a fruit spiral juicer, keeping the rotating speed at 50 revolutions per minute, adding the particles at a constant speed, keeping the feeding speed at 1 kg per minute, discharging fruit residues, and enabling thick fruit juice to flow out from the bottom through a filter screen;
3) using a centrifuge, keeping the rotating drum speed at 1000 rpm, adding the concentrated juice obtained in the step 2) at a constant speed, and keeping the feeding speed at 0.2m3Discharging separated residues in one minute to obtain clear juice;
4) naturally precipitating the fruit juice in a conical precipitation tank for 3 hours, filtering the supernatant by a high-speed tubular centrifuge at the rotation speed of 16000r/min to obtain clear and transparent noni fruit juice without precipitate, insoluble and suspended particles, and discarding the precipitate;
5) and (4) carrying out spray drying on the clear juice liquid obtained in the step (4), keeping the rotating speed of a high-speed centrifugal atomizer at 6000 rpm, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 50Pa, keeping the inlet temperature at the top of the tower at 220 ℃, keeping the outlet temperature at the bottom of the tower at 100 ℃, carrying out pulse rapping for 10 times/min, stabilizing the feeding flow of a screw pump at 80L/min, and continuously carrying out spray drying to obtain the noni fruit powder with the granularity of 200 meshes.
Preparation of aloe extract:
1) weighing aloe raw materials, putting into an extraction tank, adding 6 times of drinking water, and soaking for 2 hours at 10 ℃;
2) starting a condenser of the extraction tank and heating with steam, controlling the temperature of the extraction tank to 50 ℃ and performing ultrasonic treatment for 0.5h, extracting the extract from the bottom of the extraction tank, adding the extract into the top of the extraction tank, performing closed cycle for 0.5h, repeating the ultrasonic treatment and the closed cycle for 2 times, filtering to obtain extract, and discharging residues;
3) feeding the extracting solution into a settling tank for natural settling for 3 hours, taking supernatant, filtering by a high-speed tubular centrifuge at the rotating speed of 16000r/min to obtain the extracting solution which is free of precipitate insoluble and suspended particles and poor in light transmittance, and discarding precipitates;
4) filtering the extractive solution with high speed tubular centrifuge with membrane filter with pore diameter of 0.1 μm, and maintaining the filtration pressure at 0.4MPa to obtain clear and transparent Aloe extractive solution with good light transmittance;
5) vacuum concentrating the extractive solution at 60 deg.C under-0.07 MPa until the specific gravity is 1.2, collecting the concentrated extract, spreading the concentrated extract on a rotary baking tray, placing the baking tray on the rotary baking tray, microwave drying at 60 deg.C under-0.07 MPa, and collecting when the water content is 5%; then pulverizing the dried aloe paste with a 5.5KW universal pulverizer, and sieving to obtain aloe extract with particle size of 80 meshes.
Preparation of granules of the composition:
1) weighing: weighing 50 parts of moringa leaf extract, 6 parts of emblic leafflower powder, 6 parts of noni powder and 6 parts of aloe extract according to parts by weight for later use;
2) mixing and granulating: putting the materials weighed in the step 1) into a wet mixing granulator, mixing for 25 minutes, and spraying a mixture of the materials and alcohol in a weight ratio of 1:0.025 percent of edible alcohol, and continuously operating the mixer granulator for 20 minutes to discharge the materials to obtain wet particles;
3) and (3) fluidized drying of wet particles: placing the wet granules on an air distribution plate of a drying chamber of a fluidized drying machine, adjusting the air inlet pressure of the drying chamber to be 0.5MPa and the temperature to be 100 ℃, carrying out fluidized drying, turning off an air heater when the air outlet temperature of the drying chamber rises to 60 ℃ and the moisture does not exceed 5%, and discharging when the temperature in the drying chamber falls below 40 ℃ to obtain dry granules;
4) adding the dried material particles into a granulator, and screening out particles with uniform particle size for later use; 5) subpackaging the granules with a back-sealing type granule packaging machine, wherein the packaging amount is 0.5g per bag;
6) the packed granules are irradiated and sterilized, and then packed by a barrel-type outer box, and each barrel is 30 bags.
Case 1: zhang XX, female, age 48, often constipation and difficult defecation. And also prefers to drink, frequently feel dizzy, and if XX insists on drinking the moringa oleifera leaf granules prepared in the embodiment 19 every day, 3 bags of the moringa oleifera leaf granules are taken for two weeks, so that the symptoms of constipation and dizziness caused by drinking are relieved, and the symptoms of constipation and dizziness disappear after 3 months.
Example 20
Extracting the moringa oleifera leaf extract:
1) weighing moringa leaf raw materials, putting into an extraction tank, adding 6.5 times of drinking water, and soaking for 2.5 hours;
2) starting a condenser cooling water of the extraction tank and steam heating of a jacket of the extraction tank, keeping the cooling water pressure of the condenser at 0.35MPa, keeping the steam heating pressure of the extraction tank at 0.225MPa, keeping the temperature at 82 ℃ for boiling and extracting for 30 minutes when the temperature in the extraction tank reaches 85 ℃ and the steam condensate flows back to the tank, then closing the steam of the extraction tank, and keeping the temperature in the tank at 78 ℃;
3) first percolation circulation: the infusion valve between the full-open extraction tank and the external circulation concentrator is opened, so that the extracting solution in the extraction tank enters the stainless steel circulating pump through the outlet valve, the circulating pump is started to suck the liquid of the extracting solution into the extraction tank again for continuous circulation, the valve of the extracting solution entering the circulating pump is kept fully opened, the outlet of the circulating pump is communicated with the valve in the extraction tank to be fully opened, the pipeline valve communicated with the extracting solution storage tank is closed, the liquid is sucked into the extraction tank through the circulating pump continuously, the whole process is dynamic, the dissolving speed of the active ingredients of the moringa oleifera is increased, and the extracting solution is circulated in a closed state; stopping circulation, closing a valve leading to the extraction tank from an outlet of the circulating pump, completely opening a pipeline valve leading to the extracting solution storage tank, and completely pumping out liquid in the extraction tank;
4) and (3) second percolation circulation: closing a pipeline valve leading to the extracting solution storage tank and an extracting tank liquid discharging valve, fully opening a valve leading to the extracting tank at a circulating pump outlet, fully opening a hot water tank to enter the circulating pump valve, adding hot water which is 4.8 times of the feeding amount of the moringa oleifera leaf raw material and has the temperature of 78 ℃ into the extracting storage tank, repeating the first percolation circulation operation in the step (3) after the hot water is added, completely draining the liquid in the extracting tank, and discharging moringa oleifera leaf residues;
5) uniformly mixing the first and second extracting solutions in the extracting solution storage tank, fully opening the extracting solution storage tank, introducing the fully opened extracting solution storage tank into a circulating pump valve, introducing an outlet of the fully opened circulating pump into the extracting solution storage tank valve, starting the circulating pump, circularly mixing for 30 minutes, and stopping the pump;
6) feeding the extracting solution into a settling tank for natural settling for 3 hours, taking supernatant, filtering by a high-speed tubular centrifuge with the rotating speed of 18000r/min to obtain clear and transparent moringa oleifera leaf extracting solution without sediment, insoluble and suspended particles, and discarding sediment;
7) pumping the extracting solution in the extracting solution storage tank into a jacket vacuum concentrator, heating with hot water at the temperature of 92 ℃ in a hot water tank, starting vacuum concentration, keeping the vacuum degree at-0.0725 MPa and the temperature of 62 ℃, concentrating until the specific gravity is 1.175, collecting paste, uniformly laying the concentrated paste on a baking tray of a vacuum drying oven, placing the baking tray on the baking tray, carrying out vacuum drying under the conditions of keeping the vacuum degree at-0.0725 MPa and the temperature of 62 ℃, and collecting the dried paste until the moisture content is 4.75%; then crushing the dried moringa leaf paste by using a crusher, and sieving to obtain the moringa leaf extract with the granularity of 100 meshes.
Extraction of Pu' er tea extract:
1) weighing Pu' er tea raw materials, putting into an extraction tank, adding 7 times of drinking water, keeping the temperature at 20 ℃, and soaking for 2.5 hours;
2) starting a condenser of the extraction tank to cool water and steam-heat a jacket of the extraction tank, controlling the temperature of 55 ℃ in the extraction tank to perform ultrasonic treatment for 1h, extracting the extract from the bottom of the extraction tank, adding the extract into the top of the extraction tank for closed circulation for 1h, repeating the ultrasonic treatment and the closed circulation for 3 times, filtering the extract by a 100-mesh filter screen to obtain tea liquid, and discharging tea residues;
3) feeding the tea liquid into a settling tank for natural settling for 4 hours, taking supernatant, filtering by a high-speed tubular centrifuge at the rotating speed of 18000r/min to obtain tea liquid which is free of insoluble and suspended particles and poor in light transmittance, and discarding the settled protein and impurities;
4) filtering the tea liquid filtered by the high-speed tubular centrifuge by a membrane filter with the aperture of a filter membrane of 0.2 mu m, and keeping the filtering pressure at 0.45MPa to obtain clear and transparent tea liquid with good light transmittance;
5) vacuum concentrating the extracted tea liquid, keeping vacuum degree at-0.0725 MPa and temperature 55 deg.C, concentrating to specific gravity of 1.225, collecting paste, spreading the concentrated paste on a baking tray, placing the baking tray on a rotary baking rack, performing microwave drying under the conditions of keeping vacuum degree at-0.0775 MPa and temperature 55 deg.C, and collecting when the water content is 4.25; then crushing the dried tea paste by using a 5.5KW universal crusher, and sieving to obtain the Pu' er tea extract with the granularity of 100 meshes.
Preparing emblic leafflower fruit powder:
1) removing rotten fruit and impurities from fresh wild fructus Phyllanthi, and washing with a drum-type fruit washing machine at a drum rotation speed of 18 rpm and a water spray flow of 8m3The feeding speed is kept at 9 kg/min, clean fresh fruits are obtained, and the water is drinking water;
2) using a fruit crusher, keeping the feeding speed at 6 kg/min, and crushing the cleaned fresh fruits into particles with the particle size of 4 mm;
3) a fruit screw press is used, the rotating speed is kept at 65 r/min, particles are added at a constant speed, the feeding speed is kept at 4 kg/min, fruit residues are discharged, and thick fruit juice flows out from the bottom through a filter screen;
4) using a centrifuge, keeping the rotating drum speed at 1250 revolutions per minute, adding the thick syrup juice obtained in the step 3) at a constant speed, and keeping the feeding speed at 0.4m3Discharging separated residues in one minute to obtain clear juice;
5) naturally precipitating the fruit juice in a conical precipitation tank for 3 hours, filtering the supernatant by a high-speed tubular centrifuge at the rotating speed of 18000r/min to obtain clear and transparent emblic leafflower fruit juice without precipitate, insoluble and suspended particles, and discarding the precipitate;
6) and (3) carrying out spray drying on the clear juice liquid obtained in the step (5), keeping the rotating speed of a high-speed centrifugal atomizer at 6250 revolutions per minute, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 100Pa, keeping the inlet temperature at the top of the tower at 230-240 ℃, keeping the outlet temperature at the bottom of the tower at 105 ℃, carrying out pulse rapping for 10 times per minute, stabilizing the feeding flow of a screw pump at 90L per minute, and continuously carrying out spray drying to obtain the phyllanthus emblica powder with the granularity of 250 meshes.
Preparing noni powder:
1) removing rotten fruit and impurities from fresh noni fruit, and washing with a drum-type fruit washing machine at a drum rotation speed of 12 rpm and a water spraying flow of 5m3The feeding speed is kept at 4 kg/min, clean fresh fruits are obtained, and the water is drinking water;
2) a fruit spiral juicer is used, the rotating speed is kept at 55 revolutions per minute, particles are added at a constant speed, the feeding speed is kept at 2 kilograms per minute, fruit residues are discharged, and thick fruit juice flows out from the bottom through a filter screen;
3) using a centrifuge, keeping the rotating drum speed at 1250 revolutions per minute, adding the thick syrup juice obtained in the step 2) at a constant speed, and keeping the feeding speed at 0.4m3Discharging separated residues in one minute to obtain clear juice;
4) naturally precipitating the fruit juice in a conical precipitation tank for 3 hours, filtering the supernatant by a high-speed tubular centrifuge at the rotating speed of 18000r/min to obtain clear and transparent noni fruit juice without precipitate, insoluble and suspended particles, and discarding the precipitate;
5) and (4) carrying out spray drying on the clear juice liquid obtained in the step (4), keeping the rotating speed of a high-speed centrifugal atomizer at 6250 revolutions per minute, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 100Pa, keeping the inlet temperature at the top of the tower at 225 ℃, keeping the outlet temperature at the bottom of the tower at 105 ℃, carrying out pulse rapping for 10 times per minute, stabilizing the feeding flow of a screw pump at 90L per minute, and continuously carrying out spray drying to obtain the noni fruit powder with the granularity of 250 meshes.
Preparation of aloe extract:
1) weighing aloe raw materials, putting into an extraction tank, adding 7 times of drinking water, and soaking for 2.5 hours at 20 ℃;
2) starting a condenser of the extraction tank and heating with steam, controlling the temperature of the extraction tank to 55 ℃ and carrying out ultrasonic treatment for 1h, extracting the extract from the bottom of the extraction tank, adding the extract into the top of the extraction tank for closed circulation for 1h, repeating the ultrasonic treatment and the closed circulation for 3 times, filtering to obtain an extract, and discharging residues;
3) feeding the extracting solution into a settling tank for natural settling for 3 hours, taking supernatant, filtering by a high-speed tubular centrifuge at the rotating speed of 18000r/min to obtain the extracting solution which is free of precipitate insoluble and suspended particles and poor in light transmittance, and discarding precipitates;
4) filtering the extractive solution with high speed tubular centrifuge with membrane filter with pore diameter of 0.2 μm, and maintaining the filtration pressure at 0.45MPa to obtain clear and transparent Aloe extractive solution with good light transmittance;
5) vacuum concentrating the extractive solution, keeping vacuum degree at-0.0725 MPa and 62 deg.C, concentrating to specific gravity of 1.225, collecting paste, spreading the concentrated paste on a baking tray, placing the baking tray on a rotary baking tray, microwave drying at-0.0725 MPa and 62 deg.C, drying to water content of 5.25%, and collecting; then pulverizing the dried aloe paste with a 5.5KW universal pulverizer, and sieving to obtain aloe extract with particle size of 100 meshes.
Preparation of granules of the composition:
1) weighing: weighing 55 parts of moringa leaf extract, 10 parts of emblic leafflower powder, 10 parts of noni powder, 6 parts of aloe extract and 4 parts of Pu' er tea extract for later use;
2) mixing and granulating: putting the materials weighed in the step 1) into a wet mixing granulator, mixing for 26 minutes, and spraying a mixture of the materials and alcohol in a weight ratio of 1:0.025 percent of edible alcohol, and continuously operating the mixing granulator for 22 minutes to discharge the materials to obtain wet granules;
3) and (3) fluidized drying of wet particles: placing the wet granules on an air distribution plate of a drying chamber of a fluidized drying machine, adjusting the air inlet pressure of the drying chamber to be 0.5MPa and the temperature to be 100 ℃, carrying out fluidized drying, turning off an air heater when the air outlet temperature of the drying chamber rises to 63 ℃ and the moisture does not exceed 5%, and discharging when the temperature in the drying chamber drops to be below 38 ℃ to obtain dry granules;
4) adding the dried material particles into a granulator, and screening out particles with uniform particle size for later use; 5) subpackaging the granules with a back-sealing type granule packaging machine, wherein the packaging amount is 0.5g per bag;
6) the packed granules are irradiated and sterilized, and then packed by a barrel-type outer box, and each barrel is 30 bags.
Case 2: li XX, male, 72 years old, retired teachers, have been plagued by problems of constipation and osteoporosis. The plum XX prepared by the invention in example 20 is constantly taken for 5 bags every day, so that the problems of constipation and osteoporosis are greatly improved, and the health is realized.
Example 21
Extracting the moringa oleifera leaf extract:
1) weighing moringa leaf raw materials, putting into an extraction tank, adding 7 times of drinking water, and soaking for 3 hours;
2) starting a condenser cooling water of the extraction tank and steam heating of a jacket of the extraction tank, keeping the pressure of the condenser cooling water at 0.4MPa, keeping the steam heating pressure of the extraction tank at 0.25MPa, keeping the temperature at 85 ℃ when the temperature in the extraction tank reaches 85 ℃ and steam condensate flows back into the extraction tank, boiling and extracting for 30 minutes, then closing the steam of the extraction tank, and keeping the temperature in the extraction tank at 80 ℃;
3) first percolation circulation: the infusion valve between the full-open extraction tank and the external circulation concentrator is opened, so that the extracting solution in the extraction tank enters the stainless steel circulating pump through the outlet valve, the circulating pump is started to suck the liquid of the extracting solution into the extraction tank again for continuous circulation, the valve of the extracting solution entering the circulating pump is kept fully opened, the outlet of the circulating pump is communicated with the valve in the extraction tank to be fully opened, the pipeline valve communicated with the extracting solution storage tank is closed, the liquid is sucked into the extraction tank through the circulating pump continuously, the whole process is dynamic, the dissolving speed of the active ingredients of the moringa oleifera is increased, and the extracting solution is circulated in a; stopping circulation, closing a valve leading to the extraction tank from an outlet of the circulating pump, completely opening a pipeline valve leading to the extracting solution storage tank, and completely pumping out liquid in the extraction tank;
4) and (3) second percolation circulation: closing a pipeline valve leading to an extracting solution storage tank and an extracting tank liquid discharging valve, fully opening a valve leading to the extracting tank at a circulating pump outlet, fully opening a hot water tank to enter the circulating pump valve, adding hot water which is 5 times of the feeding amount of the moringa oleifera leaf raw material and has the temperature of 80 ℃ into the extracting storage tank, repeating the first percolation circulation operation in the step (3) after the hot water is added, completely draining the liquid in the extracting tank, and discharging moringa oleifera leaf residues;
5) uniformly mixing the first and second extracting solutions in the extracting solution storage tank, fully opening the extracting solution storage tank, introducing the fully opened extracting solution storage tank into a circulating pump valve, introducing an outlet of the fully opened circulating pump into the extracting solution storage tank valve, starting the circulating pump, circularly mixing for 30 minutes, and stopping the pump;
6) feeding the extractive solution into a precipitation tank for natural precipitation for 3 hr, filtering the supernatant with a high speed tubular centrifuge at 20000r/min to obtain clear and transparent extractive solution of Moringa oleifera leaf without insoluble and suspended particulate matter, and discarding the precipitate;
7) pumping the extracting solution in the extracting solution storage tank into a jacket vacuum concentrator, heating with hot water at the temperature of 95 ℃ in a hot water tank, starting vacuum concentration, keeping the vacuum degree at-0.075 MPa and the temperature of 65 ℃, concentrating to the specific gravity of 1.2, collecting paste, uniformly paving the concentrated paste on a baking tray of a vacuum drying oven, placing the baking tray on the baking tray, carrying out vacuum drying under the conditions of keeping the vacuum degree at-0.075 MPa and the temperature of 65 ℃, and collecting the dried paste until the moisture content is 5%; then crushing the dried moringa leaf paste by using a crusher, and sieving to obtain a moringa leaf extract with the granularity of 120 meshes.
Extraction of Pu' er tea extract:
1) weighing Pu' er tea raw materials, putting into an extraction tank, adding 8 times of drinking water, maintaining the temperature at 30 ℃, and soaking for 3 hours;
2) starting a condenser of the extraction tank to cool water and steam-heat a jacket of the extraction tank, controlling the temperature of the extraction tank to 60 ℃ and carrying out ultrasonic treatment for 1.5h, then extracting the extract from the bottom of the extraction tank and adding the extract into the top of the extraction tank for closed cycle for 1.5h, repeating the ultrasonic treatment and the closed cycle for 4 times, filtering the extract by a 100-mesh filter screen to obtain tea liquid, and discharging tea residues;
3) feeding the tea liquid into a settling tank for natural settling for 4 hours, taking supernatant, filtering by a high-speed tubular centrifuge with the rotating speed of 20000r/min to obtain the tea liquid which is free of insoluble and suspended particles and poor in light transmittance, and discarding the settled protein and impurities;
4) filtering the tea liquid filtered by the high-speed tubular centrifuge by a membrane filter with the aperture of a filter membrane of 0.22 mu m, and keeping the filtering pressure at 0.5MPa to obtain clear and transparent tea liquid with good light transmittance;
5) vacuum concentrating the extracted tea liquid, keeping vacuum degree at-0.075 MPa and 60 deg.C, concentrating to specific gravity of 1.25, collecting paste, spreading the concentrated paste on a baking tray, placing the baking tray on a rotary baking rack, performing microwave drying at-0.08 MPa and 60 deg.C, drying to water content of 4.5%, and collecting; then crushing the dried tea paste by using a 5.5KW universal crusher, and sieving to obtain the Pu' er tea extract with the granularity of 120 meshes.
Preparing emblic leafflower fruit powder:
1) removing rotten fruit and impurities from fresh wild fructus Phyllanthi, and washing with a drum-type fruit washing machine at a drum rotation speed of 20 rpm and a water spray flow of 10m3H, keeping the feeding speed at 10 kilograms per minute to obtain clean fresh fruits, wherein the water is drinking water;
2) using a fruit crusher, keeping the feeding speed at 8 kg/min, and crushing the cleaned fresh fruits into particles with the particle size of 5 mm;
3) a fruit screw press is used, the rotating speed is kept at 70 r/min, particles are added at a constant speed, the feeding speed is kept at 5 kg/min, fruit residues are discharged, and thick fruit juice flows out from the bottom through a filter screen;
4) using a centrifugal machine, keeping the rotating drum speed at 1500 rpm, adding the thick syrup juice obtained in the step 3) at a constant speed, and keeping the feeding speed at 0.5m3Discharging separated residues in one minute to obtain clear juice;
5) delivering the fruit juice into a conical precipitation tank for natural precipitation for 3 hours, filtering the supernatant by a high-speed tubular centrifuge with the rotation speed of 20000r/min to obtain clear and transparent phyllanthus emblica fruit juice without precipitate insoluble and suspended particulate matters, and discarding the precipitate;
6) and (3) carrying out spray drying on the clear juice liquid obtained in the step (5), keeping the rotating speed of a high-speed centrifugal atomizer at 6500 r/min, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 200Pa, keeping the inlet temperature at the top of the tower at 240 ℃, keeping the outlet temperature at the bottom of the tower at 120 ℃, carrying out pulse rapping for 10 times/min, stabilizing the feeding flow of a screw pump at 100L/min, and continuously carrying out spray drying to obtain the phyllanthus emblica powder with the granularity of 300 meshes.
Preparing noni powder:
1) removing rotten fruit and impurities from fresh noni fruit, and washing with drum type fruit washing machine at drum rotation speed of 15 rpm and water spray flow of 7m3H, the feed rate was kept at 5 kg/min to giveCleaning fresh fruits, wherein the water is drinking water;
2) using a fruit spiral juicer, keeping the rotating speed at 60 revolutions per minute, adding the particles at a constant speed, keeping the feeding speed at 3 kilograms per minute, discharging fruit residues, and enabling thick fruit juice to flow out from the bottom through a filter screen;
3) using a centrifugal machine, keeping the rotating drum speed at 1500 rpm, adding the thick syrup juice obtained in the step (2) at a constant speed, and keeping the feeding speed at 0.5m3Discharging separated residues in one minute to obtain clear juice;
4) naturally precipitating the fruit juice in a conical precipitation tank for 3 hr, filtering the supernatant with a high-speed tubular centrifuge at 20000r/min to obtain clear and transparent noni fruit juice without insoluble and suspended particles, and discarding the precipitate;
5) and (4) carrying out spray drying on the clear juice liquid obtained in the step (4), keeping the rotating speed of a high-speed centrifugal atomizer at 6500 r/min, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 200Pa, keeping the inlet temperature at the top of the tower at 230 ℃, keeping the outlet temperature at the bottom of the tower at 110 ℃, carrying out pulse rapping for 10 times/min, stabilizing the feeding flow of a screw pump at 100L/min, and continuously carrying out spray drying to obtain the noni fruit powder with the granularity of 300 meshes.
Preparation of aloe extract:
1) weighing aloe raw materials, putting into an extraction tank, adding 8 times of drinking water, keeping the temperature at 30 ℃, and soaking for 3 hours;
2) starting a condenser of the extraction tank and heating with steam, controlling the temperature of the extraction tank to 60 ℃ and performing ultrasonic treatment for 1.5h, extracting the extract from the bottom of the extraction tank, adding the extract into the top of the extraction tank for 1.5h in a closed cycle, repeating the ultrasonic treatment and the closed cycle for 4 times, filtering to obtain extract, and discharging residues;
3) feeding the extracting solution into a settling tank for natural settling for 3 hours, taking supernatant, filtering by a high-speed tubular centrifuge with the rotating speed of 20000r/min to obtain the extracting solution which is free of precipitate insoluble and suspended particles and poor in light transmittance, and discarding precipitates;
4) filtering the extractive solution with high speed tubular centrifuge with membrane filter with pore diameter of 0.22 μm, and maintaining the filtration pressure at 0.5MPa to obtain clear and transparent Aloe extractive solution with good light transmittance;
5) vacuum concentrating the extractive solution at 65 deg.C under-0.075 MPa until the specific gravity is 1.25, collecting the concentrated extract, spreading the concentrated extract on a baking tray, placing the baking tray on a rotary baking tray, microwave drying at 65 deg.C under-0.075 MPa, and collecting the dried extract until the water content is 5.5%; then pulverizing the dried aloe paste by using a 5.5KW universal pulverizer, and sieving to obtain the aloe extract with the granularity of 120 meshes.
Preparation of granules of the composition:
1) weighing: weighing 60 parts of moringa leaf extract, 8 parts of emblic leafflower powder, 7 parts of noni powder, 4 parts of aloe extract, 7 parts of Pu' er tea extract, 3 parts of aspartame and 11 parts of cyclodextrin for later use;
2) mixing and granulating: putting the materials weighed in the step 1) into a wet mixing granulator, mixing for 28 minutes, and spraying a mixture of the materials and alcohol in a weight ratio of 1:0.025 percent of edible alcohol, and continuously operating the mixing granulator for 23 minutes to discharge the materials to obtain wet granules;
3) and (3) fluidized drying of wet particles: placing the wet granules on an air distribution plate of a drying chamber of a fluidized drying machine, adjusting the air inlet pressure of the drying chamber to be 0.5MPa and the temperature to be 100 ℃, carrying out fluidized drying, turning off an air heater when the air outlet temperature of the drying chamber rises to 65 ℃ and the moisture does not exceed 5%, and discharging when the temperature in the drying chamber falls below 35 ℃ to obtain dry granules;
4) adding the dried material particles into a granulator, and screening out particles with uniform particle size for later use; 5) subpackaging the granules with a back-sealing type granule packaging machine, wherein the packaging amount is 0.5g per bag;
6) the packed granules are irradiated and sterilized, and then packed by a barrel-type outer box, and each barrel is 30 bags.
Case 3: zhao XX, female, age 23, low body immunity, easily ill. Zhao XX insists on taking 5 bags of granules containing the moringa oleifera leaf extract prepared in the embodiment 21 every day, and the granules are taken continuously for 3 months, so that the immunity is obviously improved, the disease occurrence frequency is greatly reduced, the health is realized, and the people feel energetic.
Claims (5)
1. The moringa oleifera leaf extract-containing composition is characterized by being prepared from the following raw materials in parts by weight: 50-65 parts of moringa leaf extract, 6-11 parts of emblic leafflower powder, 6-15 parts of noni powder, 2-8 parts of aloe extract, 2-10 parts of Pu' er tea extract and 1-8 parts of aspartame, wherein:
the extraction method of the moringa oleifera leaf extract comprises the following steps:
1) extraction: weighing the moringa oleifera leaf raw material, putting the moringa oleifera leaf raw material into an extraction tank, adding 3-7 times of purified water, and soaking for 1-3 hours; heating the extraction tank by steam, keeping the temperature at 80-85 ℃ for extraction for 25-35 min, then keeping the temperature at 75-80 ℃ for percolation extraction, keeping the extracting solution in the extraction tank and a circulating pump for closed circulating extraction for 4-5 h, stopping circulation, and leading out liquid in the extraction tank to obtain a first extracting solution; adding hot water with the temperature of 75-80 ℃ which is 4-5 times of the feeding amount of the moringa oleifera leaf raw material into the extraction tank, keeping the extracting solution in the extraction tank and the circulating pump for closed circulation for 4-5 hours, then leading out a second extracting solution, combining the second extracting solution with the first extracting solution and uniformly mixing; discarding the moringa leaves;
2) separation: standing and precipitating the extracting solution obtained in the step 1) for 2-4 h, taking the supernatant, centrifuging and filtering at a high speed to obtain a pure moringa oleifera leaf extracting solution, and discarding the precipitate;
3) concentration: introducing the moringa oleifera leaf extracting solution obtained in the step 2) into a concentrator, vacuumizing and concentrating until the relative specific gravity is 1.15-1.2, and collecting paste;
4) and (3) drying: vacuum drying the concentrated paste obtained in the step 3) until the moisture content is 4.5-5%, and collecting to obtain moringa oleifera leaf paste;
5) and (3) post-treatment: crushing the moringa leaf paste obtained in the step 4) by using a crusher, and sieving to obtain a moringa leaf extract for later use;
the preparation method of the emblic leafflower fruit powder comprises the following steps:
1) removing rotten fruits and impurities from fresh wild phyllanthus emblica fruits, and then using a drum-type fruit washing machine, wherein the drum rotating speed is kept at 15-20 r/min, and the water spraying flow is 5-10 m3The feed rate is kept between 8 and 10 kg/minObtaining clean fresh fruits, wherein the water is drinking water;
2) using a fruit crusher, keeping the feeding speed at 5-8 kg/min, and crushing the cleaned fresh fruits into particles with the particle size of 2-5 mm;
3) a fruit screw press is used, the rotating speed is kept at 60-70 r/min, particles are added at a constant speed, the feeding speed is kept at 3-5 kg/min, fruit residues are discharged, and thick fruit juice flows out from the bottom through a filter screen;
4) using a centrifugal machine, keeping the drum speed at 1000-1500 rpm, adding the thick pulp juice obtained in the step 3) at a constant speed, and keeping the feeding speed at 0.2-0.5 m3Discharging separated residues in one minute to obtain clear juice;
5) the juice is sent into a conical settling tank for natural settling for 3 hours, the supernatant is filtered by a high-speed tubular centrifuge with the rotating speed of 16000-20000 r/min, clear and transparent emblic leafflower fruit juice without sediment, insoluble and suspended particles is obtained, and the sediment is discarded;
6) spray drying the clear juice liquid obtained in the step 5), keeping the rotating speed of a high-speed centrifugal atomizer at 6000-6500 r/min, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 50-200 Pa, keeping the temperature of an inlet at the top of the tower at 230-240 ℃, keeping the temperature of an outlet at the bottom of the tower at 110-120 ℃, performing pulse vibration for 10 times/min, stabilizing the feeding flow of a screw pump at 80-100L/min, and continuously performing spray drying to obtain phyllanthus emblica powder with the particle size of 200-300 meshes;
the preparation method of the noni powder comprises the following steps:
1) removing rotten fruits and impurities from fresh noni fruits, and then using a drum-type fruit washing machine, wherein the drum rotation speed is kept at 10-15 r/min, and the water spraying flow is 3-7 m3The feeding speed is kept at 3-5 kg/min, clean fresh fruits are obtained, and the water is drinking water;
2) a fruit spiral juicer is used, the rotating speed is kept at 50-60 rpm, particles are added at a constant speed, the feeding speed is kept at 1-3 kg/min, fruit residues are discharged, and thick fruit juice flows out from the bottom through a filter screen;
3) using a centrifuge, the drum speed is kept between 1000 and 1500r/min, adding the thick syrup juice obtained in the step 2) at a constant speed, and keeping the feeding speed at 0.2-0.5 m3Discharging separated residues in one minute to obtain clear juice;
4) naturally precipitating the fruit juice in a conical precipitation tank for 3 hours, filtering the supernatant by a high-speed tubular centrifuge at the rotating speed of 16000-20000 r/min to obtain clear and transparent noni fruit juice without precipitate, insoluble and suspended particles, and discarding the precipitate;
5) carrying out spray drying on the clear juice liquid obtained in the step 4), keeping the rotating speed of a high-speed centrifugal atomizer at 6000-6500 r/min, adjusting the air volume ratio of air supply and induced air, keeping a spraying system at a negative pressure of 50-200 Pa, keeping the temperature of an inlet at the top of the tower at 220-230 ℃, keeping the temperature of an outlet at the bottom of the tower at 100-110 ℃, carrying out pulse rapping for 10 times/min, stabilizing the feeding flow of a screw pump at 80-100L/min, and continuously carrying out spray drying to obtain noni fruit powder with the particle size of 200-300 meshes;
the preparation method of the aloe extract comprises the following steps:
1) weighing aloe raw materials, putting the aloe raw materials into an extraction tank, adding 6-8 times of drinking water, keeping the temperature at 10-30 ℃, and soaking for 2-3 hours;
2) starting a condenser of the extraction tank and steam heating, performing ultrasonic treatment for 0.5-1.5 h at the temperature of 50-60 ℃ when the temperature in the extraction tank reaches 50-60 ℃, extracting the extract from the bottom of the tank, adding the extract into the top of the tank, performing closed cycle for 0.5-1.5 h, repeating the operation of ultrasonic treatment and closed cycle for 2-4 times, filtering to obtain extract, and discharging residues;
3) feeding the extracting solution into a settling tank for natural settling for 3 hours, taking supernatant, filtering by a high-speed tubular centrifuge at the rotating speed of 16000-20000 r/min to obtain the extracting solution which is free of precipitate insoluble and suspended particles and poor in light transmittance, and discarding precipitates;
4) filtering the extract filtered by the high-speed tubular centrifuge by a membrane filter with the aperture of a filter membrane of 0.1-0.22 mu m, and keeping the filtering pressure at 0.4-0.5 MPa to obtain clear and transparent aloe extract with good light transmission;
5) vacuum concentrating the extracting solution, keeping the vacuum degree at-0.07 to-0.075 MPa and the temperature of 60 to 65 ℃, concentrating until the specific gravity is 1.2 to 1.25, collecting the paste, uniformly paving the concentrated paste on a baking tray, putting the baking tray on a rotating baking rack, keeping the vacuum degree at-0.07 to-0.075 MPa and the temperature of 60 to 65 ℃, performing microwave drying, and collecting when the water content is 5 to 5.5 percent; then crushing the dried aloe paste by using a 5.5KW universal crusher, and sieving to obtain an aloe extract with the granularity of 80-120 meshes;
the extraction method of the Pu' er tea extract comprises the following steps:
1) extraction: weighing a Pu' er tea raw material, putting the raw material into an extraction tank, adding 3-8 times of drinking water, keeping the temperature at 10-30 ℃, and soaking for 2-3 hours; heating the extraction tank by steam, controlling the temperature to be 50-60 ℃, performing ultrasonic treatment for 0.5-1.5 h, performing closed-loop circulation on the leaching liquor for 0.5-1.5 h, repeating the ultrasonic treatment and the closed-loop circulation for 2-4 times, filtering to obtain tea liquid, and discarding tea residues;
2) separation: firstly, carrying out centrifugal filtration, naturally precipitating the tea liquid obtained in the step 1) for 3-5 hours, taking supernatant liquid, carrying out high-speed centrifugal filtration to obtain the tea liquid with poor light transmittance, and discarding the precipitate; then, filtering with a filter membrane, and filtering the centrifugally filtered tea liquid with the filter membrane, wherein the aperture of the filter membrane is 0.1-0.22 μm to obtain the tea liquid with good light transmittance;
3) concentration: vacuum concentrating the tea liquid separated in the step 2) until the specific gravity is 1.2-1.25, and collecting paste;
4) and (3) drying: carrying out microwave drying on the concentrated paste obtained in the step 3), and collecting the dried paste until the moisture content is 4-4.5% to obtain Pu' er tea paste;
5) and (3) post-treatment: crushing the Pu 'er tea paste obtained in the step 4) by using a crusher, and sieving to obtain a Pu' er tea extract for later use.
2. A preparation method of the moringa oleifera leaf extract-containing composition according to claim 1, which is characterized in that the preparation method comprises the steps of weighing raw materials in parts by weight, putting the raw materials into a wet mixing granulator, mixing for 25-35 min, spraying 95% edible alcohol with the weight ratio of the materials to the alcohol being 1:0.025, mixing, granulating for 20-30 min, and discharging to obtain the composition.
3. A preparation containing the moringa oleifera leaf extract composition according to claim 1, wherein the composition is prepared into granules, tablets, powders, capsules, liquid preparations or pills by adding pharmaceutically acceptable auxiliary materials.
4. The formulation of claim 3, wherein said excipient comprises a cyclodextrin.
5. The use of the moringa oleifera leaf extract-containing composition according to claim 1 in the preparation of medicaments for prevention/adjuvant treatment of toxin expelling, bowel relaxing, alcohol effect dispelling, liver protecting and calcium supplementing.
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