CN108096391A - A kind of composition and preparation method containing Panax Notoginseng Folium Saponins, preparation and application - Google Patents
A kind of composition and preparation method containing Panax Notoginseng Folium Saponins, preparation and application Download PDFInfo
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- CN108096391A CN108096391A CN201810052923.XA CN201810052923A CN108096391A CN 108096391 A CN108096391 A CN 108096391A CN 201810052923 A CN201810052923 A CN 201810052923A CN 108096391 A CN108096391 A CN 108096391A
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The invention discloses a kind of composition containing Panax Notoginseng Folium Saponins and preparation method, preparation and application, the composition includes the raw material of following parts by weight：40 ~ 70 parts of Panax Notoginseng Folium Saponins, 8 ~ 20 parts of green-tea extract, 1 ~ 5 part of ginseng extract, 1 ~ 5 part of grape seed ultramicro-farina.The present invention composition is promoting blood circulation and removing blood stasis, lipid-loweringing, blood pressure lowering, detumescence ding-tong, improves microcirculation, the significant effect of strengthen immunity; using cool blood, promoting blood circulation and removing blood stasis, enhancing metabolism, oxidation resistant material optimization prescription, blood vessel and heart, strengthen immunity are protected while cardiovascular disease is treated, accelerates fat metabolism.
Description
Technical field
The invention belongs to health-oriented products preparing technical fields, and in particular to a kind of composition containing Panax Notoginseng Folium Saponins and
Its preparation method, preparation and application.
Background technology
Due to the accelerating rhythm of life, the increase of pressure and undesirable habits and customs cause the in vivo blood vessel rubbish of body
Accumulation is excessive, causes three high（Blood fat height, high blood pressure, blood glucose are high）, artery sclerosis.Have become hot issue, three height are modern
The natural enemy of people, disturbs us normally to live, and blood vessel rubbish excessively affects the health of body, causes dizzy, pectoralgia, greatly
The daily life for affecting us.Nowadays many people are particularly middle-aged and elderly people by three high puzzlements.How to treat
Three carry out health care, protection blood vessel and heart and the significant problem that should be studied instantly while high.
Treatment currently on the market or to improve cardiovascular and cerebrovascular product various, but it is most of belong to drug, and price, greatly
Crowd is difficult to often consume, and it is uncomfortable to improve the various aspects of body, need to take multiple product, palliative or even have very big
Side effect.Therefore a kind of health care simultaneously, protection blood vessel and heart are researched and developed, with diet-therapy health-preserving, reduces by three height and develops into
The product of serious cardiovascular and cerebrovascular disease is necessary.
The content of the invention
The first object of the present invention is to provide a kind of composition containing Panax Notoginseng Folium Saponins, and second is designed to provide
A kind of preparation method of the composition containing Panax Notoginseng Folium Saponins, the 3rd be designed to provide it is a kind of containing Panax Notoginseng Folium Saponins
The preparation of composition, the 4th is designed to provide a kind of application of the composition of Panax Notoginseng Folium Saponins.
The first object of the present invention is achieved in that the raw material for including following parts by weight：Panax Notoginseng Folium Saponins 40 ~ 70
Part, 8-20 parts of green-tea extract, 1 ~ 5 part of ginseng extract, 1 ~ 5 part of grape seed ultramicro-farina.
The second object of the present invention is achieved in that the preparation method to weigh raw material input mixing by weight
In machine, after mixing 25 ~ 35 minutes, add in dry granulating machine, keep nip pressure 10-14MPa, roll rotational speed 5-8r/min,
10 r/min of charging rate) dry granulation is carried out, obtain the composition that granularity is 50-60 mesh.
The third object of the present invention is achieved in that the preparation pharmaceutically connects to be added in the composition
The auxiliary material received is prepared into granule, tablet, powder, capsule, liquid preparation, pill, medicinal tea.
The fourth object of the present invention is achieved in that the composition is preparing prevention/adjuvant therapy of cardiovascular disease
Application in the drug or health food of disease.
Compared with prior art, beneficial effects of the present invention：
1st, composition of the invention is promoting blood circulation and removing blood stasis, lipid-loweringing, blood pressure lowering, detumescence ding-tong, improves microcirculation, the effect of strengthen immunity
Significantly, cool blood, promoting blood circulation and removing blood stasis, enhancing metabolism, oxidation resistant material optimization prescription are employed, while cardiovascular disease is treated
It protects blood vessel and heart, strengthen immunity, accelerate fat metabolism.
2nd, Panax Notoginseng Folium Saponins are micro- with promoting blood circulation and removing blood stasis, lipid-loweringing, blood pressure lowering, detumescence ding-tong, improvement in raw material of the present invention
The effects that cycling；Green-tea extract lipid-loweringing, weight-reducing, beauty treatment, decompression, anti arteriosclerosis, antitumor, nourishing the stomach, sterilization, anti-aging etc.
Effect；Ginseng extract has cardiac stimulant, Hemorrhagic shock, excited hypophysis（Adrenal system）, improve stress reaction ability, enhancing body
Immune function, the effects that reinforcing vital energy, is antifatigue, is hypoglycemic；Grape seed ultramicro-farina have anti-aging, reducing blood lipid, protection skin,
Beautifying face and moistering lotion, antiallergy, radioresistance, protect eyes, protection angiocarpy, the effect of strengthen immunity；Protein sugar has anti-hemostasis
Sugar increases, adjusts the effects that mouthfeel, protection gastric mucosa.Further, it is possible to add betadex as auxiliary material, have and adjust mouth
Sense reduces the effects that bitter taste and peculiar smell, moisture-proof anti-caking in dispensing.It is acted in composition the effect of various raw materials so that this
The invention composition containing notoginseng haulm is in good taste, promote the production of body fluid to quench thirst, protect blood vessel and heart, accelerates fat metabolism can simultaneously enhance
Immunity.
3rd, dosage form of the invention can be prepared into granulated quickly dissolving, thus the melting to finished product, color and luster, it is limpid it is transparent,
Mouthfeel, effect, bioavilability etc. are more demanding, and raw material of the invention uses different preprocess methods, notoginseng haulm raw material
Fiber is more, thermal sensitivity is strong, unfavorable instant absorption and preparation processing, so being conducive to improve using low temperature seepage pressure effects concentration technique
Bioavilability；The unfavorable instant absorption of green tea materials and preparation processing, so being extracted using the diacolation technology for principle of making tea effective
Composition；Ginseng is planted using boiling and diacolation technology extraction fine powder, grape pip using Ultramicro-powder, is conducive to preparation processing, favourable
In raising bioavilability；Beauty of this process advan in product, flavouring taste, enhancing is promoting blood circulation and removing blood stasis, lipid-loweringing, blood pressure lowering, disappears
Swollen analgesic therapy improves microcirculation, strengthen immunity effect, greatly improves product active ingredient concentration, mouthfeel is more preferable, effect is more aobvious
It writes.Granule is made in product, make processing, take, preserve, carry it is extremely convenient, for realize large-scale production create condition.
4th, between each raw material of the invention, cooperate, complement each other, inventive formulation combinatorial principle：Notoginseng haulm
Raw extract, be the promoting blood circulation and removing blood stasis, lipid-loweringing of the present invention, blood pressure lowering, detumescence ding-tong, improve microcirculation play a decisive role it is main
Dispensing, while increase and reinforce vital energy with ginseng, accelerate the flowing of blood night, the effect of the major-minor reinforcing effect that matches formed with notoginseng haulm,
But notoginseng haulm, ginseng bitter taste are too dense, it is difficult to entrance；Green-tea extract has enhancing diarrhea, heat-clearing, the work for neutralizing uric acid
With, but cold in nature also easy stimulation enteron aisle induces enteritis, so increasing with grape seed ultramicro-farina, grape seed ultramicro-farina is mild-natured, has
The mouthfeel of aftertaste sweetness, the tartaric acid of grape seed ultramicro-farina can with food digesting stomach fortifying and promote the production of body fluid, fructose can be with additional heat and vigour, day
Right vitamin C and hepatocuprein [SOD] can not only be counteracted notoginseng haulm and be carried with strengthen immunity, grape seed ultramicro-farina
The side effect of object is taken, but also with anti-aging, protection blood vessel, the excitometabolic effect of increasing；Protein sugar favorably increases metabolism and mouth
Sense；Betadex can prevent the bitter taste and peculiar smell in product caking, the moisture absorption, reduction dispensing, enhanced products fragrance.Extract
Dispensing and the direct dispensing of raw material combine, and constitute the formula that the present invention optimizes.
5th, notoginseng haulm material effective component ratio of the present invention is relatively low, and not only effective ingredient and absorptivity are low aobvious for direct dispensing
Do not go out effect now, and preparation processing is difficult, and so by extracting, obtained Panax Notoginseng Folium Saponins are notoginseng haulm
Glycosides.For guaranteed quality, extracted in technique using edible alcohol, it can be ensured that active ingredient selectively dissolves out to the greatest extent, technology
Upper using low-temperature dynamic, continuously extraction and macroreticular resin isolate and purify, and are seen off at once after solute dissolution, make solute in extractor
Gradient increase is dissolved out, extracts more complete, speed faster.Low-temperature dynamic utmostly protects active ingredient not to be destroyed, equivalent
In the case of feeding intake, opposite boil puies forward technique, and mouthfeel is more preferable, effective ingredient concentration higher, and leaf is isolated and purified out using macroreticular resin
Glycosides makes more remarkable treatment effect.
6th, on the one hand the present invention effectively filters out micron-sized particulate matter, and flow diameter scope using ceramic membrane filter
Between 0.060-0.250 feet, this structure is not easy that film is caused to block, and is very easy to cleaning, and filtering traffic attenuation is slow, i.e.,
Make, when blocking serious, can also obtain satisfied flow value；Ceramic membrane cleaning operation is simple, and required time is short, and expense is low, and film
It is seldom that object is stored up in component, accelerates the notoginseng haulm extracting solution rate of filtration；Another aspect ceramic membrane filter chemical stability is strong,
It will not corrode during notoginseng haulm extracting solution high because temperature and strong basicity, pollute notoginseng haulm extracting solution.
Specific embodiment
With reference to embodiment, the present invention is further illustrated, but the present invention is not any limitation as in any way,
Based on present invention teach that any conversion or replacement made, all belong to the scope of protection of the present invention.
Composition of the present invention containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：Notoginseng haulm carries
Take 40 ~ 70 parts of object, 8 ~ 20 parts of green-tea extract, 1 ~ 5 part of ginseng extract, 1 ~ 5 part of grape seed ultramicro-farina.
The composition containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：Panax Notoginseng Folium Saponins 50 ~
60 parts, 10 ~ 15 parts of green-tea extract, 2 ~ 4 parts of ginseng extract, 2 ~ 4 parts of grape seed ultramicro-farina.
The composition containing Panax Notoginseng Folium Saponins further includes the raw material of following parts by weight：0.5 ~ 1 part of protein sugar.
The extracting method of the Panax Notoginseng Folium Saponins includes：
1）Extraction：Notoginseng haulm raw material is used to the 80-85% edible alcohols of 6 ~ 7 times of amounts, when immersion 2 ~ 3 is small；Extractor is cold
Condenser cooling water pressure is maintained at 0.3 ~ 0.4MPa, and extractor steam heated pressure is maintained at 0.2 ~ 0.25MPa, temperature in tank to be extracted
Degree reaches 75 DEG C, edible alcohol steam condensate is when being back in tank, keeps the temperature at 75 ~ 80 DEG C and boils and proposes reflux 100 ~ 120
Minute, the liquid in extractor is all drained, obtains first time extracting solution；Then the 80-85% edible wines of 4 ~ 5 times of amounts are added in
Essence repeats after the completion of operating for the first time, the liquid in extractor is all drained, obtains second of extracting solution, notoginseng haulm slag
It is discharged after recovered alcohol；
2）Mixing：First time extracting solution and second of extracting solution Xun Huan are mixed 25 ~ 35 minutes, obtain uniformly mixed Radix Notoginseng stem
Leaf extract；
3）Ceramic membrane filter：Notoginseng haulm extracting solution is subjected to ceramic membrane filter, control feed pressure enters membrane pressure in 1.5 BAR
Power is in 2.5-3.5 BAR, and transmembrane pressure is in 1.0 BAR, when cycles of concentration is more than 6, starts plus washing filter, and amount of water is keeps
Circulating tank liquid level remain unchanged for degree, when cycles of concentration reach 10, terminate filtering, obtain it is limpid it is transparent, color is light, without precipitation
Insoluble and suspended particulate substance notoginseng haulm filtered fluid；
4）It isolates and purifies：Notoginseng haulm filtered fluid is pumped into inspissator, is heated with 90 DEG C ~ 95 DEG C of hot water, starts to recycle wine
Essence, temperature is maintained at 73 ~ 78 DEG C in tank, when the alcohol concentration in extracting solution is less than 40%, stops recovered alcohol；Wine will be recycled
Filtered fluid after essence is at the uniform velocity added in macroporous resin column, and flow control is in 20-30 liters per minute, when liquid is all by macroreticular resin
After absorption, it is colourless to be rinsed with drinking water to efflux, then is eluted with 70-75% edible alcohols, rinses and extremely uses aceticanhydride-dense sulphur
Sour reaction assay eluent is feminine gender, stops rinsing, collects eluent；Eluent is pumped into inspissator, with 90 DEG C ~ 95 DEG C
Hot water heats, and starts recovered alcohol, and temperature is maintained at 73 ~ 78 DEG C in tank, when the alcohol concentration in extracting solution is less than 40%, stops
Only recovered alcohol；Start to be concentrated in vacuo after recovered alcohol, keep vacuum degree in 60 ~ 65 DEG C of -0.07 ~ -0.075MPa, temperature, it is dense
It is reduced to proportion and receives cream for 1.15 ~ 1.12；
5）Receive cream drying：, progress vacuum is done under the conditions of condensed cream is kept vacuum degree -0.07 ~ -0.075MPa, 60 ~ 65 DEG C of temperature
It is dry, it is dry to rewinding during moisture 4.5% ~ 5%, it crushes, sieving, obtains the Panax Notoginseng Folium Saponins that granularity is 80 ~ 120 mesh.
The extracting method of the ginseng extract includes：
1）Extraction：Plantation ginseng raw material is broken for the particle of 10-20 mesh, the drinking water of 6 ~ 7 times of amounts are added in, when immersion 2 ~ 3 is small；
Extractor condenser cooling water pressure is maintained at 0.3 ~ 0.4MPa, steam heated pressure is maintained at 0.2 ~ 0.25MPa, treats warm in tank
Degree reaches 97 DEG C, water vapor condensate is when being back in tank, keep the temperature at 93 ~ 97 DEG C boil carry 2 it is small when, be then shut off extracting
Tank steam all drains the liquid in extractor, obtains first time extracting solution；Then by 4 ~ 5 times of ginseng raw material's inventorys
, temperature be 75 DEG C ~ 80 DEG C hot water add in extractor, after hot water adds, carry out seepage pressure effects, keep extracting solution in extractor
With sealing and circulating in circulating pump 4 ~ 5 it is small when, then the liquid in extractor is all drained, obtains second of extracting solution, by people
Join slag discharge；
2）Centrifugal filtration：ON cycle pump circulation mixes 25 ~ 35 minutes, first time extracting solution and second of extracting solution is mixed equal
It is even；When extracting solution natural sedimentation 2 ~ 4 by evenly mixing is small, high speed of the supernatant by rotating speed for 16000 ~ 20000r/min is taken
Tube centrifuge filters, obtain limpid transparent, color it is relatively deep, without precipitating insoluble and suspended particulate substance Ginseng extract, precipitation
It is discarded；
3）Cream drying is received in concentration：Ginseng filtered fluid is pumped into inspissator, is heated, started with the hot water that temperature is 90 DEG C ~ 95 DEG C
It is concentrated in vacuo, keeps vacuum degree in 60 ~ 65 DEG C of -0.07 ~ -0.075MPa, temperature, be concentrated into proportion as 1.15 ~ 1.2, receive cream, it will
Condensed cream is uniformly laid on the baking tray of vacuum microwave drying case, and baking tray is placed on grill, and holding vacuum degree -0.07 ~ -
Vacuum microwave drying is carried out under the conditions of 0.075MPa, 60 ~ 65 DEG C of temperature, it is dry to rewinding during moisture 4.5% ~ 5%；It then will be dry
Dry ginseng extract crushes, sieving, obtains the ginseng extract that granularity is 80 ~ 120 mesh.
The extracting method of the green-tea extract includes：
1）Seepage pressure effects：Green tea materials are crushed to 50-60 mesh, it first will be green using the drinking water of 80 ~ 90% weight of green tea materials powder
Tea raw material powder infiltrates, and is then charged into cylindrical percolator, place 1 it is small when, then be slowly added that 2-3 times of green tea materials powder measures drink
Water, after solution from exporting in outflow and percolator after air emptying, closing baiting valve, the solution of outflow is bled back with pump circulation filters
Device keeps liquid level to be higher by surface of material, closed, keeps being warming up to 50 ~ 60 DEG C with pump after when dipping 3-4 is small at 20-25 DEG C of temperature
Circulatory displacement, pump circulation diacolation flow are maintained at 0.5M per minute3, constantly measured during diacolation from 2-3 times of supplement above, temperature
Spend the drinking water for 50 ~ 60 DEG C, liquid level kept to be higher by surface of material, when pump circulation diacolation 2-3 is small after, stop diacolation, be vented tea
Liquid is filtered dry tea grounds；
2）Filtering：By step（1）When obtained tea liquid natural sedimentation 3 ~ 5 is small, it is 16000 ~ 20000r/ that supernatant is taken, which to pass through rotating speed,
The high speed tube centrifuge filtering of min, obtains the tea liquid poor without insoluble and suspended particulate substance, translucency is precipitated, precipitates
Protein and impurity discard；The tea liquid Jing Guo centrifugal filtration is passed through into the Membrane filtering machine mistake that filter sizes are 0.1 ~ 0.22 μm again
Filter, filter pressure are maintained at 0.4 ~ 0.5MPa, obtain limpid tea liquid transparent, translucency is good；
3）It is concentrated and dried：By step（2）Obtained tea liquid is concentrated in vacuo, and keeps vacuum degree in -0.07 ~ -0.075MPa, temperature
50 ~ 60 DEG C of degree, it is 1.2 ~ 1.25 to be concentrated into proportion, receives cream, condensed cream is uniformly laid on baking tray, baking tray is placed on rotation
On grill, keep carrying out microwave drying under the conditions of vacuum degree -0.075 ~ -0.08MPa, temperature 50 C ~ 60 DEG C, it is dry to moisture
Rewinding when 4% ~ 4.5%；Then by dry tea cream, crush, sieving, obtain the green-tea extract that granularity is 80 ~ 120 mesh.
It by granularity is broken to grape pip powder is 80 ~ 100 mesh that the preparation method of the grape seed ultramicro-farina, which is, obtains grape
Then grape pip fine powder is intermittently added in micronizer by seed fine powder, keep rotating speed in 200 ~ 250 turns/mir, grind rail pressure power
In 2.5 ~ 3kgf/cm2, air quantity is in 1000 ~ 1400m3/ h carries out ultramicro grinding, obtains the grape pip that granularity is 500 ~ 600 mesh and surpasses
Micro mist.
The preparation method of composition of the present invention containing Panax Notoginseng Folium Saponins puts into weigh raw material by weight
It in mixer, after mixing 25 ~ 35 minutes, adds in dry granulating machine, keeps nip pressure 10-14MPa, roll rotational speed 5-
8r/min, 10 r/min of charging rate carry out dry granulation, obtain granularity as 50 ~ 60 mesh compositions.
The preparation of composition of the present invention containing Panax Notoginseng Folium Saponins is to add in pharmacy in the composition
The auxiliary material of upper receiving is prepared into granule, tablet, powder, capsule, liquid preparation, pill, medicinal tea.
The application of the composition of Panax Notoginseng Folium Saponins of the present invention is preparing prevention/auxiliary for the composition
Treat the application in the drug or health food of angiocardiopathy.
Embodiment 1
A kind of composition containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：40 parts of Panax Notoginseng Folium Saponins, green tea
8 parts of extract, 1 part of ginseng extract, 1 part of grape seed ultramicro-farina.
Embodiment 2
A kind of composition containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：70 parts of Panax Notoginseng Folium Saponins, green tea
20 parts of extract, 5 parts of ginseng extract, 5 parts of grape seed ultramicro-farina.
Embodiment 3
A kind of composition containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：50 parts of Panax Notoginseng Folium Saponins, green tea
10 parts of extract, 2 parts of ginseng extract, 2 parts of grape seed ultramicro-farina.
Embodiment 4
A kind of composition containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：60 parts of Panax Notoginseng Folium Saponins, green tea
15 parts of extract, 4 parts of ginseng extract, 4 parts of grape seed ultramicro-farina.
Embodiment 5
A kind of composition containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：45 parts of Panax Notoginseng Folium Saponins, green tea
10 parts of extract, 2 parts of ginseng extract, 2 parts of grape seed ultramicro-farina, 0.5 part of protein sugar.
Embodiment 6
A kind of composition containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：55 parts of Panax Notoginseng Folium Saponins, green tea
12 parts of extract, 3 parts of ginseng extract, 3 parts of grape seed ultramicro-farina, 1 part of protein sugar.
Embodiment 7
A kind of composition containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：65 parts of Panax Notoginseng Folium Saponins, green tea
14 parts of extract, 4 parts of ginseng extract, 4 parts of grape seed ultramicro-farina, 0.6 part of protein sugar.
Embodiment 8
A kind of composition containing Panax Notoginseng Folium Saponins includes the raw material of following parts by weight：48 parts of Panax Notoginseng Folium Saponins, green tea
16 parts of extract, 3.5 parts of ginseng extract, 2.5 parts of grape seed ultramicro-farina, 0.7 part of protein sugar.
Embodiment 9
A kind of preparation method of the composition containing Panax Notoginseng Folium Saponins, the preparation method are the weight as described in embodiment 1
Amount part is weighed in raw material input mixer, after mixing 25 minutes, is added in dry granulating machine, is kept nip pressure 10MPa, roll
Roller rotating speed 5r/min, 10 r/min of charging rate carry out dry granulation, obtain granularity as 50 mesh compositions.
Wherein, the extracting method of the Panax Notoginseng Folium Saponins includes：
1）Extraction：Notoginseng haulm raw material is used to the 80-85% edible alcohols of 6 times of amounts, when immersion 2 is small；By extractor condenser
Cooling water pressure is maintained at 0.3MPa, and extractor steam heated pressure is maintained at 0.2MPa, and temperature reaches 75 DEG C, food in tank to be extracted
When being back to alcohol steam condensate liquid in tank, keep the temperature at 75 DEG C boil carry reflux 100 minutes, by the liquid in extractor
It all drains, obtains first time extracting solution；Then 80% edible alcohol of 4 times of amounts is added in, is repeated after the completion of operating for the first time, it will
Liquid in extractor is all drained, and is obtained second of extracting solution, is discharged after notoginseng haulm slag recovered alcohol；
2）Mixing：First time extracting solution and second of extracting solution Xun Huan are mixed 25 minutes, obtain uniformly mixed notoginseng haulm
Extracting solution；
3）Ceramic membrane filter：Notoginseng haulm extracting solution is subjected to ceramic membrane filter, control feed pressure enters membrane pressure in 1.5 BAR
Power is in 2.5BAR, and transmembrane pressure is in 1.0 BAR, when cycles of concentration is more than 6, starts plus washing filter, and amount of water is keeps cycling
Tank liquid level remain unchanged for degree, when cycles of concentration reach 10, terminate filtering, obtain it is limpid it is transparent, color is light, without precipitate it is insoluble
And the notoginseng haulm filtered fluid of suspended particulate substance；
4）It isolates and purifies：Notoginseng haulm filtered fluid is pumped into inspissator, is heated with 90 DEG C of hot water, starts recovered alcohol, tank
Interior temperature is maintained at 73 DEG C, when the alcohol concentration in extracting solution is less than 40%, stops recovered alcohol；By the mistake after recovered alcohol
Filtrate is at the uniform velocity added in macroporous resin column, flow control at 20 liters per minute, when liquid all by macroporous resin adsorption after, with drink
It is colourless to be rinsed with water to efflux, then is eluted with 70% edible alcohol, rinses to aceticanhydride-strong sulfuric acid response and measures elution
Liquid is feminine gender, stops rinsing, collects eluent；Eluent is pumped into inspissator, is heated with 90 DEG C DEG C of hot water, starts to recycle
Alcohol, temperature is maintained at 73 DEG C in tank, when the alcohol concentration in extracting solution is less than 40%, stops recovered alcohol；Recovered alcohol
After start to be concentrated in vacuo, keep vacuum degree in -0.07MPa, temperature 60 C, be concentrated into proportion and receive cream for 1.15；
5）Receive cream drying：, condensed cream is kept being dried in vacuo under the conditions of vacuum degree -0.07MPa, temperature 60 C, drying is extremely
Rewinding during moisture 4.5% crushes, sieving, obtains the Panax Notoginseng Folium Saponins that granularity is 80 mesh.
The extracting method of the ginseng extract includes：
1）Extraction：Plantation ginseng raw material is broken for the particle of 10 mesh, the drinking water of 6 times of amounts are added in, when immersion 2 is small；It will extraction
Tank condenser cooling water pressure is maintained at 0.3MPa, and steam heated pressure is maintained at 0.2MPa, treats that temperature reaches 97 DEG C, water steaming in tank
When vapour condensate liquid is back in tank, keep the temperature at 93 DEG C boil carry 2 it is small when, be then shut off extractor steam, will be in extractor
Liquid all drain, obtain first time extracting solution；Then by 4 ~ 5 times of ginseng raw material's inventorys, heat that temperature is 75 DEG C
Water adds in extractor, after hot water adds, carries out seepage pressure effects, keeps extracting solution sealing and circulating 4 in extractor and circulating pump small
When, then the liquid in extractor is all drained, second of extracting solution is obtained, ginseng residue is discharged；
2）Centrifugal filtration：ON cycle pump circulation mixes 25 minutes, and first time extracting solution and second of extracting solution are uniformly mixed；
When extracting solution natural sedimentation 2 by evenly mixing is small, high speed tube centrifuge of the supernatant by rotating speed for 16000r/min is taken
Filtering, obtain limpid transparent, color it is relatively deep, without insoluble and suspended particulate substance Ginseng extract is precipitated, precipitation is discarded；
3）Cream drying is received in concentration：Ginseng filtered fluid is pumped into inspissator, is heated with hot water at a temperature of 90 °C, it is dense to start vacuum
Contracting keeps vacuum degree in -0.07MPa, temperature 60 C, is concentrated into proportion as 1.15, receives cream, condensed cream is uniformly laid on vacuum
On the baking tray of microwave drying oven, baking tray is placed on grill, keeps carrying out vacuum under the conditions of vacuum degree -0.07MPa, temperature 60 C
Microwave drying, it is dry to rewinding during moisture 4.5%；Then by dry ginseng extract, crush, sieving, obtain granularity as 80 purposes
Ginseng extract.
The extracting method of the green-tea extract includes：
1）Seepage pressure effects：Green tea materials are crushed to 50 mesh, first using the drinking water of 80% weight of green tea materials powder by green tea materials
Powder infiltrates, and is then charged into cylindrical percolator, when placement 1 is small, then is slowly added the drinking water of 2 times of amounts of green tea materials powder, treats molten
For liquid from exporting in outflow and percolator after air emptying, closing baiting valve, the solution of outflow returns percolator with pump circulation, keeps liquid
Face is higher by surface of material, closed, keeps being warming up to 50 DEG C with pump circulation diacolation after when dipping 3 is small at 20 DEG C of temperature, pump circulation is oozed
Flow of filtering is maintained at 0.5M per minute3, constantly protected during diacolation from the drinking water for supplementing 2 times of amounts above, temperature is 50 DEG C
Hold liquid level and be higher by surface of material, when pump circulation diacolation 2 is small after, stop diacolation, be vented tea liquid, be filtered dry tea grounds；
2）Filtering：By step（1）When obtained tea liquid natural sedimentation 3 is small, height of the supernatant by rotating speed for 16000r/min is taken
Fast tube centrifuge filtering, obtains the tea liquid poor without insoluble and suspended particulate substance, translucency is precipitated, the protein to precipitate
It is discarded with impurity；The tea liquid Jing Guo centrifugal filtration is filtered by the Membrane filtering machine that filter sizes are 0.1 μm again, filtration pressure is tried hard to keep
It holds in 0.4MPa, obtains limpid tea liquid transparent, translucency is good；
3）It is concentrated and dried：By step（2）Obtained tea liquid is concentrated in vacuo, and keeps vacuum degree in -0.07MPa, temperature 50 C,
It is 1.2 to be concentrated into proportion, receives cream, condensed cream is uniformly laid on baking tray, baking tray is placed on the grill of rotation, keeps vacuum
Microwave drying is carried out under the conditions of degree -0.075MPa, temperature 50 C DEG C, it is dry to rewinding during moisture 4%%；Then by dry tea
Cream crushes, sieving, obtains the green-tea extract that granularity is 80 mesh.
It by granularity is broken to grape pip powder is 80 mesh that the preparation method of the grape seed ultramicro-farina, which is, and it is thin to obtain grape pip
Then grape pip fine powder is intermittently added in micronizer by powder, keep rotating speed in 200 turns/mir, grind rail pressure power in 2.5kgf/
cm2, air quantity is in 1000m3/ h carries out ultramicro grinding, obtains the grape seed ultramicro-farina that granularity is 500 mesh.
Embodiment 10
A kind of preparation method of the composition containing Panax Notoginseng Folium Saponins, the preparation method are the parts by weight by embodiment 4
It weighs in raw material input mixer, after mixing 35 minutes, adds in dry granulating machine, keep nip pressure 14MPa, roll turns
Fast 8r/min, 10 r/min of charging rate carry out dry granulation, obtain granularity as 60 mesh compositions.
The extracting method of the Panax Notoginseng Folium Saponins includes：
1）Extraction：Notoginseng haulm raw material is used to 85% edible alcohol of 7 times of amounts, when immersion 3 is small；Extractor condenser is cooled down
Hydraulic pressure is maintained at 0.4MPa, and extractor steam heated pressure is maintained at 0.25MPa, and temperature reaches 75 DEG C, eats in tank to be extracted
When alcohol steam condensate liquid is back in tank, keep the temperature at 80 DEG C boil carry reflux 120 minutes, the liquid in extractor is complete
Portion drains, and obtains first time extracting solution；Then 85% edible alcohol of 5 times of amounts is added in, repeats after the completion of operating for the first time, will carry
The liquid in tank is taken all to drain, second of extracting solution is obtained, is discharged after notoginseng haulm slag recovered alcohol；
2）Mixing：First time extracting solution and second of extracting solution Xun Huan are mixed 35 minutes, obtain uniformly mixed notoginseng haulm
Extracting solution；
3）Ceramic membrane filter：Notoginseng haulm extracting solution is subjected to ceramic membrane filter, control feed pressure enters membrane pressure in 1.5 BAR
Power is in 3.5 BAR, and transmembrane pressure is in 1.0 BAR, when cycles of concentration is more than 6, starts plus washing filter, and amount of water is keeps cycling
Tank liquid level remain unchanged for degree, when cycles of concentration reach 10, terminate filtering, obtain it is limpid it is transparent, color is light, without precipitate it is insoluble
And the notoginseng haulm filtered fluid of suspended particulate substance；
4）It isolates and purifies：Notoginseng haulm filtered fluid is pumped into inspissator, is heated with 95 DEG C of hot water, starts recovered alcohol, tank
Interior temperature is maintained at 78 DEG C, when the alcohol concentration in extracting solution is less than 40%, stops recovered alcohol；By the mistake after recovered alcohol
Filtrate is at the uniform velocity added in macroporous resin column, flow control at 30 liters per minute, when liquid all by macroporous resin adsorption after, with drink
It is colourless to be rinsed with water to efflux, then is eluted with 75% edible alcohol, rinses to aceticanhydride-strong sulfuric acid response and measures elution
Liquid is feminine gender, stops rinsing, collects eluent；Eluent is pumped into inspissator, is heated with 95 DEG C of hot water, starts to recycle wine
Essence, temperature is maintained at 78 DEG C in tank, when the alcohol concentration in extracting solution is less than 40%, stops recovered alcohol；After recovered alcohol
Start to be concentrated in vacuo, keep vacuum degree in 65 DEG C of -0.075MPa, temperature, be concentrated into proportion and receive cream for 1.12；
5）Receive cream drying：, condensed cream is kept being dried in vacuo under the conditions of vacuum degree -0.075MPa, 65 DEG C of temperature, drying is extremely
Rewinding during moisture 5% crushes, sieving, obtains the Panax Notoginseng Folium Saponins that granularity is 120 mesh.
The extracting method of the ginseng extract includes：
1）Extraction：Plantation ginseng raw material is broken for the particle of 20 mesh, the drinking water of 7 times of amounts are added in, when immersion 3 is small；It will extraction
Tank condenser cooling water pressure is maintained at 0.4MPa, and steam heated pressure is maintained at 0.25MPa, treats that temperature reaches 97 DEG C, water in tank
When steam condensate is back in tank, keep the temperature at 97 DEG C boil carry 2 it is small when, extractor steam is then shut off, by extractor
Interior liquid is all drained, and obtains first time extracting solution；Then by 5 times of ginseng raw material's inventorys, heat that temperature is 80 DEG C
Water adds in extractor, after hot water adds, carries out seepage pressure effects, keeps extracting solution sealing and circulating 5 in extractor and circulating pump small
When, then the liquid in extractor is all drained, second of extracting solution is obtained, ginseng residue is discharged；
2）Centrifugal filtration：ON cycle pump circulation mixes 35 minutes, and first time extracting solution and second of extracting solution are uniformly mixed；
When extracting solution natural sedimentation 4 by evenly mixing is small, high speed tube centrifuge of the supernatant by rotating speed for 20000r/min is taken
Filtering, obtain limpid transparent, color it is relatively deep, without insoluble and suspended particulate substance Ginseng extract is precipitated, precipitation is discarded；
3）Cream drying is received in concentration：Ginseng filtered fluid is pumped into inspissator, is heated with the hot water that temperature is 95 DEG C, it is dense to start vacuum
Contracting keeps vacuum degree in 65 DEG C of -0.075MPa, temperature, is concentrated into proportion as 1.2, receives cream, condensed cream is uniformly laid on vacuum
On the baking tray of microwave drying oven, baking tray is placed on grill, keeps carrying out very under the conditions of vacuum degree -0.075MPa, 65 DEG C of temperature
Empty microwave drying, it is dry to rewinding during moisture 5%；Then by dry ginseng extract, crush, sieving, obtain granularity as 120 purposes
Ginseng extract.
The extracting method of the green-tea extract includes：
1）Seepage pressure effects：Green tea materials are crushed to 60 mesh, first using the drinking water of 90% weight of green tea materials powder by green tea materials
Powder infiltrates, and is then charged into cylindrical percolator, when placement 1 is small, then is slowly added the drinking water of 3 times of amounts of green tea materials powder, treats molten
For liquid from exporting in outflow and percolator after air emptying, closing baiting valve, the solution of outflow returns percolator with pump circulation, keeps liquid
Face is higher by surface of material, closed, keeps being warming up to 60 DEG C with pump circulation diacolation after when dipping 4 is small at 25 DEG C of temperature, pump circulation is oozed
Flow of filtering is maintained at 0.5M per minute3, constantly protected during diacolation from the drinking water for supplementing 3 times of amounts above, temperature is 60 DEG C
Hold liquid level and be higher by surface of material, when pump circulation diacolation 3 is small after, stop diacolation, be vented tea liquid, be filtered dry tea grounds；
2）Filtering：By step（1）When obtained tea liquid natural sedimentation 5 is small, height of the supernatant by rotating speed for 20000r/min is taken
Fast tube centrifuge filtering, obtains the tea liquid poor without insoluble and suspended particulate substance, translucency is precipitated, the protein to precipitate
It is discarded with impurity；The tea liquid Jing Guo centrifugal filtration is filtered by the Membrane filtering machine that filter sizes are 0.22 μm again, filter pressure
0.5MPa is maintained at, obtains limpid tea liquid transparent, translucency is good；
3）It is concentrated and dried：By step（2）Obtained tea liquid is concentrated in vacuo, and keeps vacuum degree in -0.075MPa, temperature 60
DEG C, it is 1.25 to be concentrated into proportion, receives cream, condensed cream is uniformly laid on baking tray, baking tray is placed on the grill of rotation, is kept
Microwave drying is carried out under the conditions of vacuum degree -0.08MPa, temperature 60 C, it is dry to rewinding during moisture 4.5%；It then will be dry
Tea cream crushes, sieving, obtains the green-tea extract that granularity is 120 mesh.
It by granularity is broken to grape pip powder is 100 mesh that the preparation method of the grape seed ultramicro-farina, which is, obtains grape pip
Then grape pip fine powder is intermittently added in micronizer by fine powder, keep rotating speed in 250 turns/mir, grind rail pressure power in 3kgf/
cm2, air quantity is in 1400m3/ h carries out ultramicro grinding, obtains the grape seed ultramicro-farina that granularity is 600 mesh.
Embodiment 11
A kind of preparation method of the composition containing Panax Notoginseng Folium Saponins, the preparation method are the parts by weight by embodiment 8
It weighs in raw material input mixer, after mixing 30 minutes, adds in dry granulating machine, keep nip pressure 12MPa, roll turns
Fast 6r/min, 10 r/min of charging rate carry out dry granulation, obtain granularity as 50 mesh compositions.
The extracting method of the Panax Notoginseng Folium Saponins includes：
1）Extraction：Notoginseng haulm raw material is used to 82% edible alcohol of 6.5 times of amounts, when immersion 2.5 is small；By extractor condenser
Cooling water pressure is maintained at 0.35MPa, and extractor steam heated pressure is maintained at 0.225MPa, and temperature reaches 75 in tank to be extracted
DEG C, edible alcohol steam condensate is when being back in tank, keeps the temperature at 78 DEG C and boils and proposes reflux 110 minutes, will be in extractor
Liquid all drain, obtain first time extracting solution；Then 82% edible alcohol of 4.5 times of amounts is added in, repeats to operate for the first time
After finishing, the liquid in extractor is all drained, obtains second of extracting solution, discharged after notoginseng haulm slag recovered alcohol；
2）Mixing：First time extracting solution and second of extracting solution Xun Huan are mixed 30 minutes, obtain uniformly mixed notoginseng haulm
Extracting solution；
3）Ceramic membrane filter：Notoginseng haulm extracting solution is subjected to ceramic membrane filter, control feed pressure enters membrane pressure in 1.5 BAR
Power is in 3 BAR, and transmembrane pressure is in 1.0 BAR, when cycles of concentration is more than 6, starts plus washing filter, and amount of water is keeps circulating tank
Liquid level remain unchanged for degree, when cycles of concentration reach 10, terminate filtering, obtain it is limpid it is transparent, color is light, without precipitate it is insoluble and
The notoginseng haulm filtered fluid of suspended particulate substance；
4）It isolates and purifies：Notoginseng haulm filtered fluid is pumped into inspissator, is heated with 92 DEG C of hot water, starts recovered alcohol, tank
Interior temperature is maintained at 75 DEG C, when the alcohol concentration in extracting solution is less than 35%, stops recovered alcohol；By the mistake after recovered alcohol
Filtrate is at the uniform velocity added in macroporous resin column, flow control at 25 liters per minute, when liquid all by macroporous resin adsorption after, with drink
It is colourless to be rinsed with water to efflux, then is eluted with 72% edible alcohol, rinses to aceticanhydride-strong sulfuric acid response and measures elution
Liquid is feminine gender, stops rinsing, collects eluent；Eluent is pumped into inspissator, is heated with 92 DEG C of hot water, starts to recycle wine
Essence, temperature is maintained at 75 DEG C in tank, when the alcohol concentration in extracting solution is less than 35%, stops recovered alcohol；After recovered alcohol
Start to be concentrated in vacuo, keep vacuum degree in -0.07MPa, temperature 60 C, be concentrated into proportion and receive cream for 1.15；
5）Receive cream drying：, condensed cream is kept being dried in vacuo under the conditions of vacuum degree -0.0725MPa, 62 DEG C of temperature, it is dry
It to rewinding during moisture 4.8%, crushes, sieving, obtains the Panax Notoginseng Folium Saponins that granularity is 100 mesh.
The extracting method of the ginseng extract includes：
1）Extraction：Plantation ginseng raw material is broken for the particle of 10 mesh, the drinking water of 6.5 times of amounts are added in, when immersion 2.5 is small；It will
Extractor condenser cooling water pressure is maintained at 0.35MPa, and steam heated pressure is maintained at 0.225MPa, treats that temperature reaches 97 in tank
DEG C, water vapor condensate is when being back in tank, keep the temperature at 95 DEG C boil carry 2 it is small when, be then shut off extractor steam, will carry
The liquid in tank is taken all to drain, obtains first time extracting solution；Then by 4.5 times of ginseng raw material's inventorys, temperature 78
DEG C hot water add in extractor, after hot water adds, carry out seepage pressure effects, keep that extracting solution is closed in extractor and circulating pump follows
When ring 4.5 is small, then the liquid in extractor is all drained, second of extracting solution is obtained, ginseng residue is discharged；
2）Centrifugal filtration：ON cycle pump circulation mixes 30 minutes, and first time extracting solution and second of extracting solution are uniformly mixed；
When extracting solution natural sedimentation 3 by evenly mixing is small, high speed tube centrifuge of the supernatant by rotating speed for 18000r/min is taken
Filtering, obtain limpid transparent, color it is relatively deep, without insoluble and suspended particulate substance Ginseng extract is precipitated, precipitation is discarded；
3）Cream drying is received in concentration：Ginseng filtered fluid is pumped into inspissator, is heated with the hot water that temperature is 92 DEG C, it is dense to start vacuum
Contracting keeps vacuum degree in 62 DEG C of -0.0725MPa, temperature, is concentrated into proportion as 1.2, receives cream, condensed cream is uniformly laid on true
On the baking tray of empty microwave drying oven, baking tray is placed on grill, keeps carrying out very under the conditions of vacuum degree -0.07MPa, 65 DEG C of temperature
Empty microwave drying, it is dry to rewinding during moisture 5%；Then by dry ginseng extract, crush, sieving, obtain granularity as 100 purposes
Ginseng extract.
The extracting method of the green-tea extract includes：
1）Seepage pressure effects：Green tea materials are crushed to 60 mesh, first using the drinking water of 85% weight of green tea materials powder by green tea materials
Powder infiltrates, and is then charged into cylindrical percolator, when placement 1 is small, then is slowly added the drinking water of 2.5 times of amounts of green tea materials powder, treats
For solution from exporting in outflow and percolator after air emptying, closing baiting valve, the solution of outflow returns percolator with pump circulation, keeps
Liquid level is higher by surface of material, closed, keeps being warming up to 55 DEG C with pump circulation diacolation after when dipping 3.5 is small at 22 DEG C of temperature, pump follows
Ring diacolation flow is maintained at 0.5M per minute3, constantly from the drink for supplementing 2.5 times of amounts above, temperature is 55 DEG C during diacolation
With water, liquid level is kept to be higher by surface of material, when pump circulation diacolation 2.5 is small after, stop diacolation, be vented tea liquid, be filtered dry tea grounds；
2）Filtering：By step（1）When obtained tea liquid natural sedimentation 4 is small, height of the supernatant by rotating speed for 18000r/min is taken
Fast tube centrifuge filtering, obtains the tea liquid poor without insoluble and suspended particulate substance, translucency is precipitated, the protein to precipitate
It is discarded with impurity；The tea liquid Jing Guo centrifugal filtration is filtered by the Membrane filtering machine that filter sizes are 0.2 μm again, filtration pressure is tried hard to keep
It holds in 0.45MPa, obtains limpid tea liquid transparent, translucency is good；
3）It is concentrated and dried：By step（2）Obtained tea liquid is concentrated in vacuo, and keeps vacuum degree in -0.075MPa, temperature 55
DEG C, it is 1.2 to be concentrated into proportion, receives cream, condensed cream is uniformly laid on baking tray, baking tray is placed on the grill of rotation, is kept
Microwave drying is carried out under the conditions of vacuum degree -0.075MPa, 55 DEG C of temperature, it is dry to rewinding during moisture 4.8%；It then will be dry
Tea cream crushes, sieving, obtains the green-tea extract that granularity is 100 mesh.
It by granularity is broken to grape pip powder is 90 mesh that the preparation method of the grape seed ultramicro-farina, which is, and it is thin to obtain grape pip
Then grape pip fine powder is intermittently added in micronizer by powder, keep rotating speed in 220 turns/mir, grind rail pressure power in 2.8kgf/
cm2, air quantity is in 1200m3/ h carries out ultramicro grinding, obtains the grape seed ultramicro-farina that granularity is 500 mesh.
Embodiment 12
A kind of preparation method of the composition containing Panax Notoginseng Folium Saponins, comprises the following steps：
1）It weighs：50 parts of Panax Notoginseng Folium Saponins, 10 parts of green-tea extract, 5 parts of ginseng extract, grape pip are weighed by weight
5 parts of Ultramicro-powder, 0.5 part of protein sugar, 20 parts of betadex；
2）Mixing：By step 1）In the material input two-dimensional mixing machine of middle weighing, mix 25 minutes.
3）Dry granulation：The material mixed is added in dry granulating machine, keeps nip pressure 10MPa, roll rotational speed
5r/min, 10 r/min of charging rate carry out dry granulation, obtain the composition that granularity is 50 mesh.
4）The material particles made are added in pelletizing machine, filter out the particle of even particle size, spare；
5）The good particle of whole grain is dispensed with back of the body envelope formula particles packing machine, every 0.5g of loading amount.
Wherein, the extracting method of the Panax Notoginseng Folium Saponins includes：
1）Extraction：Notoginseng haulm raw material weighing is put into extractor, adds in 80% edible alcohol of 6 times of amounts, it is small to impregnate 2
When；Extractor condenser cooling water pressure is maintained at 0.3MPa, extractor steam heated pressure is maintained at 0.2MPa, tank to be extracted
Interior temperature reaches 75 DEG C, edible alcohol steam condensate is when being back in tank, keeps the temperature at 75 DEG C and boils and proposes 100 points of reflux
Clock all drains the liquid in extractor, obtains first time extracting solution；Then 80% edible alcohol of 4 times of amounts is added in, is repeated
After the completion of operating for the first time, the liquid in extractor is all drained, obtains second of extracting solution, notoginseng haulm slag recovered alcohol
After discharge；
2）Mixing：First time extracting solution and second of extracting solution are merged into same storage tank, ON cycle pump circulation mixing 25
Minute, it extracting solution will be uniformly mixed twice；
3）Ceramic membrane filter：Notoginseng haulm extracting solution is subjected to ceramic membrane filter, control feed pressure enters membrane pressure in 1.5 BAR
Power is in 2.5BAR, and transmembrane pressure is in 1.0 BAR, when cycles of concentration is more than 6, starts plus washing filter, and amount of water is keeps cycling
Tank liquid level remain unchanged for degree, when cycles of concentration reach 10, terminate filtering, obtain it is limpid it is transparent, color is light, without precipitate it is insoluble
And the notoginseng haulm filtered fluid of suspended particulate substance.）
4）Notoginseng haulm extracting solution isolates and purifies：Notoginseng haulm extraction filtered fluid is pumped into inspissator, the hot water with 90 DEG C adds
Heat starts recovered alcohol, and temperature is maintained at 73 DEG C in tank, when the alcohol concentration in extracting solution is less than 40%, stops recycling wine
Essence；Extracting solution after recovered alcohol is at the uniform velocity added in macroporous resin column, flow control is at 20 liters per minute, when liquid whole quilt
It after macroporous resin adsorption, is rinsed to efflux to be colourless with drinking water, then is eluted with 70% edible alcohol, rinsed to using vinegar
Acid anhydride-strong sulfuric acid response measures eluent as feminine gender, stops rinsing, collects eluent；Eluent is pumped into inspissator, with 90
DEG C hot water heating, start recovered alcohol, temperature is maintained at 73 DEG C in tank, when the alcohol concentration in extracting solution is less than 40%,
Stop recovered alcohol；Start to be concentrated in vacuo after recovered alcohol, vacuum degree is kept to be concentrated into proportion in -0.07MPa, temperature 60 C
Cream is received for 1.15.
5）Receive cream drying：, condensed cream is uniformly laid on the baking tray of vacuum drying chamber, baking tray is placed on grill, is protected
It holds and is dried in vacuo under the conditions of vacuum degree -0.07MPa, temperature 60 C, it is dry to rewinding during moisture 4.5%；Then by drying
Panax Notoginseng Folium Saponins, crushed in 100,000 grades of purifying areas with pulverizer, sieve, obtain granularity be 80 mesh notoginseng haulm extract
Object.
The extracting method of the ginseng extract includes：
1）Extraction：The particle that ginseng raw material's crusher in crushing is 10 mesh will be planted, weighing is put into extractor, adds in 6 times
The drinking water of amount, when immersion 2 is small；Extractor condenser cooling water pressure is maintained at 0.3MPa, extractor steam heated pressure is protected
It holds in 0.2MPa, temperature reaches 97 DEG C in tank to be extracted, water vapor condensate is when being back in tank, keeps the temperature at 93 DEG C and boils
Carry 2 it is small when, be then shut off extractor steam, the liquid in extractor all drained, obtain first time extracting solution；Then by 4
Times ginseng raw material's inventory, hot water that temperature is 75 DEG C add in extractor, after hot water adds, carry out seepage pressure effects, keep
Then extracting solution is all drained the liquid in extractor when sealing and circulating 4 is small in extractor and circulating pump, obtained second
Extracting solution discharges ginseng residue；
2）Centrifugal filtration：ON cycle pump circulation mixes 25 minutes, and first time extracting solution and second of extracting solution are uniformly mixed；
When extracting solution natural sedimentation 2 by evenly mixing is small, high speed tube centrifuge of the supernatant by rotating speed for 16000r/min is taken
Filtering, obtain limpid transparent, color it is relatively deep, without insoluble and suspended particulate substance Ginseng extract is precipitated, precipitation is discarded；
3）Cream drying is received in concentration：Ginseng filtered fluid is pumped into inspissator, is heated with hot water at a temperature of 90 °C, it is dense to start vacuum
Contracting keeps vacuum degree in -0.07MPa, temperature 60 C, is concentrated into proportion as 1.15, receives cream, condensed cream is uniformly laid on vacuum
On the baking tray of microwave drying oven, baking tray is placed on grill, keeps carrying out vacuum under the conditions of vacuum degree -0.07MPa, temperature 60 C
Microwave drying, it is dry to rewinding during moisture 4.5%；Then by dry ginseng extract, crushed in 100,000 grades of purifying areas with pulverizer,
Sieving obtains the ginseng extract that granularity is 80 mesh.
The extracting method of the green-tea extract includes：
1）Seepage pressure effects：Green tea materials are crushed to 50 mesh addition slot to mix in machine, starts slot and mixes machine, by green tea materials fine grained weight
The drinking water of amount 80% is slowly added into infiltration, after stirring 2 minutes, pours into splicing groove, while checks that cylindrical percolator bottom pad is more
Whether hole sizer plate is intact, and is paved with two layers of husky cloth and to make tight, and whether check valve is closed tight, prevents from leaking.It will moisten in splicing groove
Wet green tea materials fine grained is packed into cylindrical percolator, and charge weight must not exceed 2/3rds of percolator volume, load
Rear surface flattens.It places one hour, opens percolator lower part drain hole valve, slowly add green tea materials fine grained 2-3 in top
The drinking water of amount again after solution is from air emptying in outlet outflow and cylinder, closes baiting valve, and the solution of outflow is returned with pump circulation
Percolator keeps liquid level to be higher by surface of material, closed, keeps being warming up to 50 DEG C with pump circulation after when dipping 3 is small at 20 DEG C of temperature
Diacolation, pump circulation diacolation flow are maintained at 0.5M3 per minute, constantly from 2 times of amounts, temperature 50 of supplement above during diacolation
DEG C drinking water, keep liquid level be higher by surface of material, when pump circulation diacolation 2 is small after, stop diacolation, be vented tea liquid, be filtered dry tea grounds.
2）Filtering：Tea liquid first carries out centrifugal filtration, by step（1）When obtained tea liquid natural sedimentation 3 is small, supernatant is taken to pass through
It crosses the high speed tube centrifuge that rotating speed is 16000r/min to filter, obtain poor without insoluble and suspended particulate substance, translucency is precipitated
Tea liquid, the protein and impurity to precipitate discards；Membrane filtration is carried out again, the filtered fenestra of the tea liquid by centrifugal filtration
The Membrane filtering machine that footpath is 0.1 μm filters, and filter pressure is maintained at 0.4MPa, obtains limpid tea liquid transparent, translucency is good；
3）It is concentrated and dried：By step（2）Obtained tea liquid is concentrated in vacuo, and keeps vacuum degree in -0.07MPa, temperature 50 C,
It is 1.2 to be concentrated into proportion, receives cream, condensed cream is uniformly laid on baking tray, baking tray is placed on the grill of rotation, keeps vacuum
Microwave drying is carried out under the conditions of degree -0.075MPa, temperature 50 C, it is dry to rewinding during moisture 4%；Then by dry tea cream,
It is crushed, sieved with pulverizer, obtain the green-tea extract that granularity is 80 mesh.
The preparation method of the grape seed ultramicro-farina includes：
It by granularity is crushed to grape pip pulverizer is 80 mesh that the preparation method of grape seed ultramicro-farina, which is, obtains grape pip fine powder,
Then flower of Radix Puerariae fine powder is intermittently added in micronizer, keeps rotating speed in 200 turns/mir, grinds rail pressure power in 2.5kgf/
cm2, air quantity is in 1000m3/ h carries out ultramicro grinding, obtains the grape seed ultramicro-farina that granularity is 500 mesh.
Test example 1
King XX, female, 45 years old, often dizzy, in June, 2017, the indices of Hospital Physical Examination were as follows：
First, heart rate：70 times per minute, blood pressure：Systolic pressure 110mmHg, 80 mmHg of diastolic pressure
2nd, blood fat：
T-CHOL：5.52 mmol/L (2.8~5 .17mmol/L)
Triglycerides：1.75 mmol/L (0 .56~1.7mmol/L)
Cholesterol ester：5.17 mmol/L（2 .8~5.17mmol/L）
High-density lipoprotein：1.10 mmol/L（0 .96~1.15mmol/L）, low-density lipoprotein：2.52 mmol/L（0~
3.1mmol/L）
It is by more than physical examination index as it can be seen that most of all higher or exceeded, therefore have above-mentioned symptom.
King XX adheres to that drinking the embodiment of the present invention 12 is prepared notoginseng haulm granule 3, takes head after two weeks daily
Dizzy symptom mitigates, and dizziness disappears after 3 months.In September, 2017, and physical examination has been done, index is as follows：
First, heart rate：75 times per minute, blood pressure：Systolic pressure 100mmHg, 75 mmHg of diastolic pressure
2nd, blood fat：
T-CHOL：4.14 mmol/L (2.8~5 .17mmol/L)
Triglycerides：0.93 mmol/L (0 .56~1.7mmol/L)
Cholesterol ester：3.75 mmol/L（2 .8~5.17mmol/L）
High-density lipoprotein：0.99 mmol/L（0 .96~1.15mmol/L）, low-density lipoprotein：2.31 mmol/L（0~
3.1mmol/L）
By more than physical examination index as it can be seen that it is most of all in acceptability limit and index optimizes very much.Therefore feel comfortable.
Claims (10)
1. a kind of composition containing Panax Notoginseng Folium Saponins, it is characterised in that include the raw material of following parts by weight：Notoginseng haulm carries
Take 40 ~ 70 parts of object, 8 ~ 20 parts of green-tea extract, 1 ~ 5 part of ginseng extract, 1 ~ 5 part of grape seed ultramicro-farina.
2. the composition according to claim 1 containing Panax Notoginseng Folium Saponins, it is characterised in that including following parts by weight
Raw material：50 ~ 60 parts of Panax Notoginseng Folium Saponins, 10 ~ 15 parts of green-tea extract, 2 ~ 4 parts of ginseng extract, grape seed ultramicro-farina 2 ~ 4
Part.
3. the composition according to claim 1 or 2 containing Panax Notoginseng Folium Saponins, it is characterised in that further include following weight
The raw material of part：0.5 ~ 1 part of protein sugar.
4. the composition according to claim 1 or 2 containing Panax Notoginseng Folium Saponins, it is characterised in that the notoginseng haulm
The extracting method of extract includes：
1）Extraction：Notoginseng haulm raw material is used to the 80-85% edible alcohols of 6 ~ 7 times of amounts, when immersion 2 ~ 3 is small；Extractor is condensed
Device cooling water pressure is maintained at 0.3 ~ 0.4MPa, and extractor steam heated pressure is maintained at 0.2 ~ 0.25MPa, temperature in tank to be extracted
Reach 75 DEG C, edible alcohol steam condensate is when being back in tank, keep the temperature at 75 ~ 80 DEG C and boil and propose 100 ~ 120 points of reflux
Clock all drains the liquid in extractor, obtains first time extracting solution；Then the 80-85% edible wines of 4 ~ 5 times of amounts are added in
Essence repeats after the completion of operating for the first time, the liquid in extractor is all drained, obtains second of extracting solution, notoginseng haulm slag
It is discharged after recovered alcohol；
2）Mixing：First time extracting solution and second of extracting solution Xun Huan are mixed 25 ~ 35 minutes, obtain uniformly mixed Radix Notoginseng stem
Leaf extract；
3）Ceramic membrane filter：Notoginseng haulm extracting solution is subjected to ceramic membrane filter, control feed pressure enters membrane pressure in 1.5 BAR
Power is in 2.5-3.5 BAR, and transmembrane pressure is in 1.0 BAR, when cycles of concentration is more than 6, starts plus washing filter, and amount of water is keeps
Circulating tank liquid level remain unchanged for degree, when cycles of concentration reach 10, terminate filtering, obtain it is limpid it is transparent, color is light, without precipitation
Insoluble and suspended particulate substance notoginseng haulm filtered fluid；
4）It isolates and purifies：Notoginseng haulm filtered fluid is pumped into inspissator, is heated with 90 DEG C ~ 95 DEG C of hot water, starts to recycle wine
Essence, temperature is maintained at 73 ~ 78 DEG C in tank, when the alcohol concentration in extracting solution is less than 40%, stops recovered alcohol；Wine will be recycled
Filtered fluid after essence is at the uniform velocity added in macroporous resin column, and flow control is in 20-30 liters per minute, when liquid is all by macroreticular resin
After absorption, it is colourless to be rinsed with drinking water to efflux, then is eluted with 70-75% edible alcohols, rinses and extremely uses aceticanhydride-dense sulphur
Sour reaction assay eluent is feminine gender, stops rinsing, collects eluent；Eluent is pumped into inspissator, with 90 DEG C ~ 95 DEG C
Hot water heats, and starts recovered alcohol, and temperature is maintained at 73 ~ 78 DEG C in tank, when the alcohol concentration in extracting solution is less than 40%, stops
Only recovered alcohol；Start to be concentrated in vacuo after recovered alcohol, keep vacuum degree in 60 ~ 65 DEG C of -0.07 ~ -0.075MPa, temperature, it is dense
It is reduced to proportion and receives cream for 1.15 ~ 1.12；
5）Receive cream drying：, progress vacuum is done under the conditions of condensed cream is kept vacuum degree -0.07 ~ -0.075MPa, 60 ~ 65 DEG C of temperature
It is dry, it is dry to rewinding during moisture 4.5% ~ 5%, it crushes, sieving, obtains the Panax Notoginseng Folium Saponins that granularity is 80 ~ 120 mesh.
5. the composition according to claim 1 or 2 containing Panax Notoginseng Folium Saponins, it is characterised in that the ginseng extraction
The extracting method of object includes：
1）Extraction：Plantation ginseng raw material is broken for the particle of 10-20 mesh, the drinking water of 6 ~ 7 times of amounts are added in, when immersion 2 ~ 3 is small；
Extractor condenser cooling water pressure is maintained at 0.3 ~ 0.4MPa, steam heated pressure is maintained at 0.2 ~ 0.25MPa, treats warm in tank
Degree reaches 97 DEG C, water vapor condensate is when being back in tank, keep the temperature at 93 ~ 97 DEG C boil carry 2 it is small when, be then shut off extracting
Tank steam all drains the liquid in extractor, obtains first time extracting solution；Then by 4 ~ 5 times of ginseng raw material's inventorys
, temperature be 75 DEG C ~ 80 DEG C hot water add in extractor, after hot water adds, carry out seepage pressure effects, keep extracting solution in extractor
With sealing and circulating in circulating pump 4 ~ 5 it is small when, then the liquid in extractor is all drained, obtains second of extracting solution, by people
Join slag discharge；
2）Centrifugal filtration：ON cycle pump circulation mixes 25 ~ 35 minutes, first time extracting solution and second of extracting solution is mixed equal
It is even；When extracting solution natural sedimentation 2 ~ 4 by evenly mixing is small, high speed of the supernatant by rotating speed for 16000 ~ 20000r/min is taken
Tube centrifuge filters, obtain limpid transparent, color it is relatively deep, without precipitating insoluble and suspended particulate substance Ginseng extract, precipitation
It is discarded；
3）Cream drying is received in concentration：Ginseng filtered fluid is pumped into inspissator, is heated, started with the hot water that temperature is 90 DEG C ~ 95 DEG C
It is concentrated in vacuo, keeps vacuum degree in 60 ~ 65 DEG C of -0.07 ~ -0.075MPa, temperature, be concentrated into proportion as 1.15 ~ 1.2, receive cream, it will
Condensed cream is uniformly laid on the baking tray of vacuum microwave drying case, and baking tray is placed on grill, and holding vacuum degree -0.07 ~ -
Vacuum microwave drying is carried out under the conditions of 0.075MPa, 60 ~ 65 DEG C of temperature, it is dry to rewinding during moisture 4.5% ~ 5%；It then will be dry
Dry ginseng extract crushes, sieving, obtains the ginseng extract that granularity is 80 ~ 120 mesh.
6. the composition according to claim 1 or 2 containing Panax Notoginseng Folium Saponins, it is characterised in that the green tea extraction
The extracting method of object includes：
1）Seepage pressure effects：Green tea materials are crushed to 50-60 mesh, it first will be green using the drinking water of 80 ~ 90% weight of green tea materials powder
Tea raw material powder infiltrates, and is then charged into cylindrical percolator, place 1 it is small when, then be slowly added that 2-3 times of green tea materials powder measures drink
Water, after solution from exporting in outflow and percolator after air emptying, closing baiting valve, the solution of outflow is bled back with pump circulation filters
Device keeps liquid level to be higher by surface of material, closed, keeps being warming up to 50 ~ 60 DEG C with pump after when dipping 3-4 is small at 20-25 DEG C of temperature
Circulatory displacement, pump circulation diacolation flow are maintained at 0.5M per minute3, constantly measured during diacolation from 2-3 times of supplement above, temperature
Spend the drinking water for 50 ~ 60 DEG C, liquid level kept to be higher by surface of material, when pump circulation diacolation 2-3 is small after, stop diacolation, be vented tea
Liquid is filtered dry tea grounds；
2）Filtering：By step（1）When obtained tea liquid natural sedimentation 3 ~ 5 is small, it is 16000 ~ 20000r/ that supernatant is taken, which to pass through rotating speed,
The high speed tube centrifuge filtering of min, obtains the tea liquid poor without insoluble and suspended particulate substance, translucency is precipitated, precipitates
Protein and impurity discard；The tea liquid Jing Guo centrifugal filtration is passed through into the Membrane filtering machine mistake that filter sizes are 0.1 ~ 0.22 μm again
Filter, filter pressure are maintained at 0.4 ~ 0.5MPa, obtain limpid tea liquid transparent, translucency is good；
3）It is concentrated and dried：By step（2）Obtained tea liquid is concentrated in vacuo, and keeps vacuum degree in -0.07 ~ -0.075MPa, temperature
50 ~ 60 DEG C of degree, it is 1.2 ~ 1.25 to be concentrated into proportion, receives cream, condensed cream is uniformly laid on baking tray, baking tray is placed on rotation
On grill, keep carrying out microwave drying under the conditions of vacuum degree -0.075 ~ -0.08MPa, temperature 50 C ~ 60 DEG C, it is dry to moisture
Rewinding when 4% ~ 4.5%；Then by dry tea cream, crush, sieving, obtain the green-tea extract that granularity is 80 ~ 120 mesh.
7. the composition according to claim 1 or 2 containing Panax Notoginseng Folium Saponins, it is characterised in that the grape pip surpasses
It by granularity is broken to grape pip powder is 80 ~ 100 mesh that the preparation method of micro mist, which is, obtains grape pip fine powder, then that grape pip is thin
Powder is intermittently added in micronizer, is kept rotating speed in 200 ~ 250 turns/mir, is ground rail pressure power in 2.5 ~ 3kgf/cm2, air quantity exists
1000~1400m3/ h carries out ultramicro grinding, obtains the grape seed ultramicro-farina that granularity is 500 ~ 600 mesh.
8. a kind of preparation method according to any composition containing Panax Notoginseng Folium Saponins of claim 1 ~ 7, feature
It is that the preparation method is put into weigh raw material by weight in mixer, after mixing 25 ~ 35 minutes, adds dry method system
In grain machine, nip pressure 10-14MPa is kept, roll rotational speed 5-8r/min, 10 r/min of charging rate carry out dry granulation, obtain
It is 50 ~ 60 mesh compositions to granularity.
9. a kind of preparation according to any composition containing Panax Notoginseng Folium Saponins of claim 1 ~ 7, it is characterised in that
The preparation is to add in the auxiliary material pharmaceutically received in the composition to be prepared into granule, tablet, powder, capsule
Agent, liquid preparation, pill, medicinal tea.
A kind of 10. application of composition according to any Panax Notoginseng Folium Saponins of claim 1 ~ 7, it is characterised in that institute
Application of the composition stated in the drug or health food for preparing prevention/adjuvant therapy of cardiovascular disease.
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