CN104224867B - A kind of desmodium sugar-free particle and preparation method thereof - Google Patents
A kind of desmodium sugar-free particle and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of desmodium sugar-free particle and preparation method thereof.The sugar-free particle includes desmodium medicinal extract, dextrin and mannitol, and desmodium sugar-free particle is applied to the patient of unsuitable sugar, particularly diabetic.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of desmodium sugar-free particle and preparation method thereof.
Background technology
There is the trend increased year by year, and the first disease as south China each province Urology Surgery in the incidence of disease of urolithiasis
Disease.Although extracorporeal shock wave and PNL, the clinical practice of ureterorenoscope stone-extraction operation in recent years, in clinic
On also achieve larger progress, but postoperative calculus residual and calculus recurrence the problems such as be still the important of Urology Surgery and ask
Topic, so the protective agents of new urolithiasis are being researched and developed in countries in the world at present.
Desmodium is Primulaceae Lysimachia plant Lysimachia christinae (Lysimachia christinae Hance), also known as
Christina loosestrife herb, to seat grass, everywhere LUBIANHUANG, Huang etc., desmodium bitter, acid is slightly cold.Return liver, courage, kidney, bladder warp.Function heat-clearing
Removing toxic substances, diuresis and stone expeling, promoting blood circulation to remove blood stasis.For liver, gall stone, cholecystitis, icterepatitis, stone in urinary system, oedema, bruise is damaged
Wound, venomous snake bite, malicious mouse and drug poisoning：Purulent inflammation, burn and scald are controlled in external application.The thatched cottage proved recipe transcript of Sichuan hundred according to legend, clearly
For qianlong yearses (1736-1795), there is desmodium to treat the record of " yellow sand walks subcutaneous ulcer ", the application in more than 200 years is at least had so far
History.Nearly 50 years, domestic scholars carried out many researchs to the chemical composition of desmodium, pharmacological action and clinical practice.Gold
Money grass Chinese medicine preparation has been used for treatment calculi in urinary system, infection and cholecystolithiasis, cholecystitis.
Initial analysis desmodium contain phenolic constituent, flavonoids, glucoside, tannin, volatile oil, amino acid, choline, sterol,
The compositions such as potassium chloride, interior lipid.Wherein flavonoids research comparison go deep into, it is separated go out 10 kinds of compounds.Chinese scientific journal
Report from the ethanol extract of desmodium after petroleum ether degreasing, upper polyamide column, with water and 20%, 50%, 70%, 90%
Ethanol carries out the process such as low pressure column chromatography and gradient elution, obtains six flavone compounds, respectively Quercetin
(Quetcetin), quercetin glucoside, Kaempferol (Kaempferol), Kaempferol galactoside, the glucoside of Kaempferol three etc.,
To the ethanol extract of desmodium by H-103 large pore resin absorption columns, then silica gel column layer folding is carried out, washed with different eluents
It is de-, obtain four kinds of flavone compounds, respectively Kaempferol -3- glycosides, Kaempferol -3- rutinoside rhamnocitrins
Diglucoside and afzelin -7- rhamanopyranosyl mouse -1-3- Lee's glucosides etc..Animal experiment proves these compositions
The excretion for having calcium in obvious diuresis, urine is reduced, the increase of citric acid excretion, and transaminase and creatinine are without change in blood
Change.Main composition can also make by ethylene glycol, activated vitamin D3The urinary calculi formation rate of the urinary tract calcinm oxalate calculus animal model caused
Significantly reduce, and ethylene glycol, activated vitamin D can be mitigated3To the detrimental effect of renal function.Prove that its main composition can be reduced to contain
The significant risk factor urinary calcium of calcium urinary calculi formation and the excretion of urine mesoxalic acid, increase the row of the citric acid of inhibiting factor containing calcium calculus
, there is the diuresis to prevention urinary calculi formation in discharge, with preventing urinary calculi from being formed, especially the effect of calcinm oxalate calculus formation
With the effect of protection renal function.
CN101352481B discloses a kind of desmodium anti-calculi fractionated extraction of Chinese medicine for being used to prevent and treat urinary calculus
The preparation method of thing.Desmodium ethanol, heating and refluxing extraction reclaims ethanol, and concentration obtains total extract, water-bath is concentrated to give alcohol
Medicinal extract, then petroleum ether, ethyl acetate, n-butanol, water fractional extraction are used successively, recycling design, concentration obtains point of desmodium respectively
Level extract oil ether moiety, ethyl acetate portion, n-butanol fraction, aqueous fraction.This method extraction process is complicated, uses
A large amount of and a variety of organic solvents, wastewater treatment is more difficult, not environmentally.
CN103087825A discloses a kind of Herba Desmodii Styracifolii extract and preparation method thereof, will dry Desmodium styracifolium and crushed 40
Mesh sieve, then Snowbellleaf Tickclover Herb is added into high concentration ethanol solvent, it is placed in upon mixing in high-pressure bottle and carries out ultra high pressure extraction,
Material residue is filtered to remove after release, deepfreeze after filtrate, adjustment filtrate pH is collected, centrifuges to obtain supernatant, produced after being concentrated under reduced pressure
To Herba Desmodii Styracifolii extract.This method uses ethanol and ultra high pressure extraction, and production safety risk is big, and ethanol recycling can increase
Production cost, uneconomical and complex operation.
CN1478515 discloses a kind of money blade and desmodium capsule, desmodium syrup, desmodium mixture and its production
Method, its production method is：Desmodium medicinal material is taken, segment (broken) is cleaned up, added water to cook 2~3 times, collecting decoction, mistake
Filter, filtrate concentration adds auxiliary material, granulation or loading capsule by weight ratio；Or quantitative syrup or honey and preservative are added, mix
Close uniform, packing obtains desmodium syrup or mixture.The extract active constituent content that this method is obtained is not high, particularly Huang
Ketone component content is relatively low, and obtained desmodium preparation curative effect is poor.
At present, money grass particle is based on the particle containing sugar, and this is particularly not suitable for glycosuria for being not suitable for sugar patient
Patient takes, and the money grass particle containing sugar can not meet their demand, therefore, and exploitation Sugarless type money grass particle has product
The social effect of pole and higher market value.
The content of the invention
Object of the present invention is to provide a kind of desmodium sugar-free particle, this is particle stabilized, nonhygroscopic, grain forming
It is good, wherein, the preparation of desmodium medicinal extract adopts water as Extraction solvent, using triple effect method for concentration, obtains high content flavonoids
The extract or medicinal extract of compound such as Quercetin and Kaempferol element, and production technology is easy to operate, environmental protection, safety, production cost are low.
To realize the purpose of the present invention, there is provided scheme is implemented as follows.
In one embodiment, a kind of desmodium sugar-free particle of the invention, the gold comprising equivalent to 20g desmodium crude drugs
Money grass medicinal extract, dextrin and mannitol, wherein, the desmodium medicinal extract is made by following methods, and this method comprises the following steps：
A) desmodium after cleaning is put into multi-function extractor, adding drinking water makes untill medicinal material is totally submerged；
B) boiling is heated to, is extracted in three times, merges and extracts decoction；
C) decoction will be extracted and removes tannin by centrifuging；
D) centrifuged supernatant is taken to add in Three-effect concentration device, heating is concentrated into relative density of the decoction at 50-60 DEG C and is
1.20-1.32 when stop concentration, obtain desmodium medicinal extract；
In the above-described embodiment, the extraction in three times in desmodium sugar-free particle of the invention, the step b):First
It is secondary to boil 1.5-2.5 hours, preferably 2 hours, filtering extraction decoction, filtering in 0.5-1.5 hours, preferably 1 hour is boiled for the second time
Decoction is extracted, 20-40 minutes, preferably 30 minutes, filtering extraction decoction are boiled for the third time, merges and extracts decoction；The three of step d)
Effect is concentrated, and its condition is：
1) steam pressure 0.05-0.09Mpa；
2) 80-90 DEG C of a temperature of effect, vacuum -0.02-0.04Mpa；
3) two 70-80 DEG C of temperature of effect, vacuum -0.04-0.06Mpa；
4) 60-70 DEG C of triple effect temperature, vacuum -0.06-0.08Mpa.
In the above-described embodiment, sugar-free particle of the invention, the weight ratio of desmodium medicinal extract, dextrin and mannitol is 1：
1：5-6, preferably 1：1：5.6 or 1.1：1.1：6.2.
In the above-described embodiment, sugar-free particle of the invention, the desmodium medicinal extract of 20g crude drugs, wherein, containing Quercetin with
The total amount of Kaempferol element should be no less than 0.80mg, preferably no less than 0.90mg.
In one embodiment, a kind of desmodium sugar-free particle of the invention, the money comprising equivalent to 20g crude drugs
Careless medicinal extract, dextrin and mannitol, wherein, the weight ratio of desmodium medicinal extract, dextrin and mannitol is 1：1：5-6, the desmodium
Medicinal extract is made by following methods, and this method comprises the following steps：
A) desmodium after cleaning is put into multi-function extractor, adding drinking water makes untill medicinal material is totally submerged；
B) boiling is heated to, is extracted in three times, merges and extracts decoction, described extract in three times includes:Boil for the first time
1.5-2.5 hours, preferably 2 hours, filtering extraction decoction, boil filtering in 0.5-1.5 hours, preferably 1 hour and extract medicine for the second time
Liquid, boils 20-40 minutes, preferably 30 minutes, filtering extraction decoction, merges and extract decoction for the third time；
C) decoction will be extracted and removes tannin by centrifuging；
D) centrifuged supernatant is taken to add in Three-effect concentration device, heating is concentrated into relative density of the decoction at 50-60 DEG C and is
Stop concentration during 1.20-1.32, obtain desmodium medicinal extract, wherein, triple effect concentration, its condition is 1) steam pressure 0.05-
0.09Mpa；2) 80-90 DEG C of a temperature of effect, vacuum -0.02-0.04Mpa；3) two 70-80 DEG C of temperature of effect, vacuum -0.04-
0.06Mpa；4) 60-70 DEG C of triple effect temperature, vacuum -0.06-0.08Mpa.
In above-mentioned specific embodiment, desmodium sugar-free particle of the invention, desmodium medicinal extract, dextrin and mannitol
Weight ratio is：1.1：1.1：6.2；The medicinal extract that 20g desmodiums crude drug is extracted, the total amount of Quercetin and Kaempferol element should be no less than
0.80mg, preferably no less than 0.90mg.
A further object of the present invention be the provision of it is a kind of prepare the present invention desmodium sugar-free particle method, including with
Lower step：
1) the desmodium medicinal extract that obtains claim 1, dextrin, mannitol are by 1.1：1.1：6.2 weight is more mixed than adding
In conjunction machine, stir and softwood, granulation is made, cross 12 mesh sieves and wet granular is made；
2) wet granular is placed in boiling drier, when drying to leaving air temp >=60 DEG C or pellet moisture reaches less than 3%,
Stop drying, whole grain is distributed into bag.
Present invention also offers a kind of method for preparing desmodium medicinal extract, comprise the following steps：
A) desmodium after cleaning is put into multi-function extractor, adding drinking water makes untill medicinal material is totally submerged；
B) boiling is heated to, is extracted in three times, merges and extracts decoction, described extract in three times includes:Boil for the first time
1.5-2.5 hours, preferably 2 hours, filtering extraction decoction, boil filtering in 0.5-1.5 hours, preferably 1 hour and extract medicine for the second time
Liquid, boils 20-40 minutes, preferably 30 minutes, filtering extraction decoction, merges and extract decoction for the third time；
C) decoction will be extracted and removes tannin by centrifuging；
D) centrifuged supernatant is taken to add in Three-effect concentration device, heating is concentrated into relative density of the decoction at 50-60 DEG C and is
1.20-1.32 when stop concentration, obtain desmodium medicinal extract；
The triple effect of the step d) is concentrated, and its condition is：
1) steam pressure 0.05-0.09Mpa；
2) 80-90 DEG C of a temperature of effect, vacuum -0.02-0.04Mpa；
3) two 70-80 DEG C of temperature of effect, vacuum -0.04-0.06Mpa；
4) 60-70 DEG C of triple effect temperature, vacuum -0.06-0.08Mpa.
Beneficial effect：The desmodium sugar-free particle of the present invention, its desmodium medicinal extract adopts water as Extraction solvent, than using second
The organic solvents such as alcohol extract more environmentally friendly, safety, and operation is centrifuged using centrifugal pump, relative to the standing of Chinese Pharmacopoeia
Separation method, shortens production time and cycle, substantially increases production efficiency, therefore, technique is more economical, and production cost is lower,
In addition, using triple effect method for concentration, than the extract or medicinal extract that traditional method for concentration obtains high content flavone compound, especially
It is that Quercetin and the plain content of Kaempferol are significantly improved, often the content of bag particle Quercetin and Kaempferol element reaches more than 0.80mg,
It can improve and use that to monitor air temperature control material moisture more accurate than other methods in curative effect, granulating process, fast.Phase
To using for controlling that particle is aqueous by determining the method for water and needing long time, thing is controlled using monitoring leaving air temp
Material moisture can be monitored at any time, simple and fast, promptly and accurately.Desmodium sugar-free is particle stabilized, non-hygroscopic, and grain forming is good, grain
Footpath is uniform in size, is applicable patient extensively, is particularly suitable for diabetic.
The screening of desmodium sugar-free particle pharmaceutical adjunct of the present invention.
Sugar-free particle often has dextrin, soluble starch, microcrystalline cellulose, lactose, mannitol, xylitol etc. with auxiliary material.This
The desmodium medicinal extract of invention is water extract, the auxiliary material of selection：Dextrin, xylitol, lactose and mannitol, make desmodium medicinal extract with
Auxiliary material is easily well mixed in facility for granulating.The species and consumption of auxiliary material directly affect the yield rate of production, by determining not
Auxiliary material is screened with the ratio of briquetting and hydroscopicity of particle made by auxiliary material.
According to every bag of loading amount containing crude drug amount and sugar-free particle to be made of original prescription, the weight of desmodium medicinal extract and auxiliary material is determined
Amount ratio, is screened to selected auxiliary material, using oscillating granulator, adds suitable quantity of water and softwood is made, particle is made, to made
Grain ratio of briquetting and hydroscopicity are tested, and score value respectively accounts for 50%, according to comprehensive grading result, select optimal auxiliary material and consumption, knot
Fruit is shown in Table 1 grain forming rate and the measure and computational methods of hydroscopicity are as follows:
(1) measure of ratio of briquetting：Sample is sieved on a sieve and No. four sieves (10~65 mesh), measure can pass through
A number sieve can not calculate ratio of briquetting by No. four particle weights sieved, and according to below equation：Ratio of briquetting (%)=(one can be passed through
Number sieve can not by No. four sieve particle weight/sample particle weight) × 100%.
(2) measure of hydroscopicity：Sample is under the conditions of packless, and it is 60% to keep relative humidity, is placed 48 hours, is claimed
It is fixed to resurvey, and calculates hydroscopicity according to below equation：Hydroscopicity (the %)=table 1 of (weight before weight-moisture absorption after moisture absorption) × 100%
The screening scheme and appraisal result of auxiliary material.
The desmodium dry extract of table 1 is mixed into the hydroscopicity and ratio of briquetting of particle with auxiliary material (medicinal extract is weight ratio with auxiliary material)
| Particulate component | Experimental group 1 | Experimental group 2 | Experimental group 3 | Experimental group 4 | Experimental group 5 | Experimental group 6 |
| Desmodium medicinal extract | 1 | 1 | 1.1 | 1 | 1 | 1.1 |
| Dextrin | 7.6 | 1 | 1.1 | 1 | 1 | |
| Mannitol | 5.6 | 6.2 | 7.2 | |||
| Lactose | 5.6 | |||||
| Microcrystalline cellulose | 5.6 | |||||
| Ratio of briquetting (%) | 75 | 89 | 91 | 70 | 60 | 68 |
| Ratio of briquetting score | 36.2 | 46.5 | 48.9 | 35.3 | 30.1 | 34.8 |
| Hydroscopicity (%) | 10.5 | 3.8 | 3.2 | 8.2 | 10.8 | 3.3 |
| Moisture absorption score | 43.1 | 46.3 | 46.5 | 44.8 | 45.4 | 43.8 |
| Total score | 79.3 | 92.8 | 95.4 | 80.1 | 75.5 | 78.6 |
As it can be seen from table 1 the ratio of briquetting highest of particle is made with mannitol combined for dextrin, hydroscopicity is also low, therefore, always
Divide highest.Although alone mannitol is made, particle hydroscopicity is low, and ratio of briquetting is also low, and alone dextrin ratio of briquetting is higher, but moisture absorption
Rate is also high, therefore, and auxiliary material can select dextrin and be mixed by a certain percentage with mannitol, and particle, mixing system is made with desmodium medicinal extract
It is difficult to cause effective ingredient to migrate because of layering during grain, makes the finished product content being made uniformly, stability is good, obtained gold
Money grass sugar-free grain forming rate is high, and hygroscopicity is low, good fluidity, is easy to packing, and solubility is good, it is easier to uses, preserve, transport
It is defeated.
Embodiment
Following examples are used for the essence for further elucidating and understanding the present invention, but do not limit the scope of the present invention with this.
The extraction of the desmodium medicinal extract of embodiment 1,
Preparation process：
1) take desmodium clean, kill into segment input multi-function extractor in, add drinking water be totally submerged medicinal material for
Only；
2) boiling is heated to, extracts, boils for the first time 2 hours in three times, decoction is extracted in filtering, is added water and is boiled 1 for the second time
Hour, decoction is extracted in filtering, and the third time that adds water is boiled 30 minutes, and decoction is extracted in filtering, and merging filtrate obtains extracting decoction；
3) decoction will be extracted and removes tannin by centrifuging；
D) centrifuged supernatant is taken to add in Three-effect concentration device, heating is concentrated into relative density of the decoction at 50-60 DEG C and is
Stop concentration during 1.20-1.32, obtain desmodium medicinal extract, wherein, the condition of triple effect concentration is 1) steam pressure 0.05-
0.09Mpa；2) 80-90 DEG C of a temperature of effect, vacuum -0.02-0.04Mpa；3) two 70-80 DEG C of temperature of effect, vacuum -0.04-
0.06Mpa；4) 60-70 DEG C of triple effect temperature, vacuum -0.06-0.08Mpa.
Embodiment 2
The preparation of desmodium sugar-free particle：
1) the desmodium medicinal extract, dextrin, mannitol of the acquisition of embodiment 1 are weighed, by 1：1：5.6 or 1.1：1.1：6.2 weight
Amount stirs and softwood, granulation is made than adding in mixer, crosses 12 mesh polyamide fibre sieve series into wet granular；
2) wet granular is placed in boiling drier, when drying to leaving air temp >=60 DEG C or pellet moisture reaches less than 3%,
Stop drying, whole grain, it is total mixed after, through being distributed into bag after the assay was approved, every bag of medicinal extract for containing equivalent to 20g desmodium crude drugs, often
Bag 10g.
Comparative example 1
Take desmodium appropriate, clean, be processed into segment, input extractor, plus drinking water water is totally submerged medicinal material, plus
Heat is extracted, boiled for the first time 2 hours to seething with excitement in three times, and decoction is extracted in filtering, is added water and is boiled for the second time 1 hour, and filtering is extracted
Decoction, the third time that adds water is boiled 30 minutes, and decoction is extracted in filtering, and merging filtrate is obtained extracting decoction, is put into common concentration tank
(non-triple effect), heating concentration, relative density when being concentrated into 60 DEG C stops when being 1.20-1.32, and medicinal extract is made, standby.
Desmodium medicinal extract, dextrin, mannitol press 1：1：5.6 weight than adding in mixer, stir be made softwood,
Granulation, crosses 12 mesh polyamide fibre sieve series into wet granular；
Wet granular is placed in boiling drier, when drying to leaving air temp >=60 DEG C or pellet moisture reaches less than 3%, is stopped
Only drying, whole grain is distributed into bag, every bag containing the medicinal extract equivalent to desmodium 20g, every bag of 10g.
Determine the total amount of Quercetin and Kaempferol
The batch of desmodium medicinal extract three is each made by the method for Examples 1 and 2, the money of three batches of correspondence is then made
Careless sugar-free particle, the total of Quercetin and Kaempferol in every bag of desmodium sugar-free particle of each batch is determined using HPLC methods respectively
Content.The desmodium medicinal extract of three batches is obtained by the method for comparative example 1, the desmodium sugar-free of correspondence batch is made
Grain, the total content of Quercetin and Kaempferol in every bag of desmodium sugar-free particle of each batch is determined using HPLC methods.As a result see
Following table.
Table：The total content of Quercetin and Kaempferol in every bag of desmodium sugar-free particle
According to upper table data result, desmodium sugar-free particle of the invention and its preparation method of desmodium medicinal extract are compared
Traditional technique (comparative example 1), significantly improves the total content of Quercetin and Kaempferol in particle, reaches and higher than existing
Quality requirement.
Simple flexible or modification is carried out on the basis of the connotation of the present invention, the protection model of the present invention is belonged to
Enclose.
Claims (6)
1. a kind of desmodium sugar-free particle, medicinal extract, dextrin and mannitol comprising equivalent to 20g desmodium crude drugs, desmodium leaching
The weight ratio of cream, dextrin and mannitol is：1：1：5-6, wherein, the desmodium medicinal extract is made by following methods, this method bag
Include following steps：
A) desmodium after cleaning is put into multi-function extractor, adding drinking water makes untill medicinal material is totally submerged；
B) boiling is heated to, is extracted in three times, merges and extracts decoction；
C) decoction will be extracted and removes tannin by centrifuging；
D) centrifuged supernatant is taken to add in Three-effect concentration device, heating is concentrated into relative density of the decoction at 50-60 DEG C for 1.20-
Stop concentration when 1.32, obtain desmodium medicinal extract；Wherein,
Three extractions in the step b) include:1.5-2.5 hours, filtering extraction decoction are boiled for the first time, are boiled for the second time
0.5-1.5 hours, filtering extraction decoction, boil 20-40 minutes, filtering extraction decoction, merge and extract decoction, the step for the third time
Suddenly triple effect d) is concentrated, and its condition is：
1) steam pressure 0.05-0.09Mpa；
2) 80-90 DEG C of a temperature of effect, vacuum -0.02-0.04Mpa；
3) two 70-80 DEG C of temperature of effect, vacuum -0.04-0.06Mpa；
4) 60-70 DEG C of triple effect temperature, vacuum -0.06-0.08Mpa,
And, the desmodium medicinal extract of 20g crude drugs, wherein, the total amount containing Quercetin and Kaempferol element should be no less than 0.80mg.
2. three extractions in desmodium sugar-free particle as claimed in claim 1, the step b) include:Boil 2 for the first time
Decoction is extracted in hour, filtering, and 1 hour, filtering extraction decoction are boiled for the second time, 30 minutes are boiled for the third time, filters and extracts decoction,
Merge and extract decoction.
3. desmodium sugar-free particle as claimed in claim 1, the weight ratio of desmodium medicinal extract, dextrin and mannitol is：1：1：
5.6。
4. desmodium sugar-free particle as claimed in claim 1, the desmodium medicinal extract of 20g crude drugs, wherein, containing Quercetin and kaempferia galamga
The total amount of phenol element should be no less than 0.90mg.
5. a kind of preparation method of any one of claim 1-4 desmodium sugar-free particle, comprises the following steps：
1) described desmodium medicinal extract, dextrin, mannitol are added in mixer, stirs and softwood, granulation is made, cross 12 mesh
Sieve series is into wet granular；
2) wet granular is placed in boiling drier, when drying to leaving air temp >=60 DEG C or pellet moisture reaches less than 3%, is stopped
Dry, whole grain is distributed into bag.
6. a kind of method of the desmodium medicinal extract prepared described in claim 1, comprises the following steps：
A) desmodium after cleaning is put into multi-function extractor, adding drinking water makes untill medicinal material is totally submerged；
B) boiling is heated to, is extracted in three times, merges and extracts decoction, three extractions include:Boil 1.5-2.5 for the first time small
When, filtering extract decoction, boil for the second time 0.5-1.5 hour, filtering extract decoction, boil for the third time 20-40 minutes, filter carry
Taking liquid, merges and extracts decoction；
C) decoction will be extracted and removes tannin by centrifuging；
D) centrifuged supernatant is taken to add in Three-effect concentration device, heating is concentrated into relative density of the decoction at 50-60 DEG C for 1.20-
Stop concentration when 1.32, obtain desmodium medicinal extract；
The triple effect of the step d) is concentrated, and its condition is：
1) steam pressure 0.05-0.09Mpa；
2) 80-90 DEG C of a temperature of effect, vacuum -0.02-0.04Mpa；
3) two 70-80 DEG C of temperature of effect, vacuum -0.04-0.06Mpa；
4) 60-70 DEG C of triple effect temperature, vacuum -0.06-0.08Mpa.
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| CN106692230B (en) * | 2017-03-16 | 2020-04-17 | 重庆科瑞制药(集团)有限公司 | Preparation method of herba lysimachiae granules |
| CN107349234A (en) * | 2017-06-20 | 2017-11-17 | 重庆和平制药有限公司 | A kind of Sugarless type desmodium preparation method of granules |
| CN113332248A (en) * | 2021-06-02 | 2021-09-03 | 祈蒙股份有限公司 | Kaempferia galanga composition particles and preparation process thereof |
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| CN101549020A (en) * | 2009-02-11 | 2009-10-07 | 海口市制药厂有限公司 | Sugar-free granular preparation of daphniphyllum-polygonum, application and preparation method thereof |
| CN102973647A (en) * | 2012-12-20 | 2013-03-20 | 广西健丰药业有限公司 | Preparation method and quality control method of sugar-free stranguria-treating and calculus-removing particles |
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