CN107349234A - A kind of Sugarless type desmodium preparation method of granules - Google Patents
A kind of Sugarless type desmodium preparation method of granules Download PDFInfo
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- CN107349234A CN107349234A CN201710467425.7A CN201710467425A CN107349234A CN 107349234 A CN107349234 A CN 107349234A CN 201710467425 A CN201710467425 A CN 201710467425A CN 107349234 A CN107349234 A CN 107349234A
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- desmodium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
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Abstract
The invention discloses a kind of Sugarless type desmodium preparation method of granules, key step includes stock, desmodium medicinal extract prepares and insulation, equipment regulation and control, auxiliary material add, heating and boiling, spraying granulating, lasting spraying and dries.Completed by boiling and desmodium medicinal extract spraying granulating, a step that auxiliary material is carried out in fluidized drying pelletizer.The present invention is reasonable in design, and relative to the wet granulation mode of prior art, involved number of devices is less, and integration of equipments, automaticity are higher, and operation is easier, and it is exposed to avoid medicine in process of production, pollutes.
Description
Technical field
The invention belongs to pharmaceutical technology technical field, specifically, more particularly to a kind of one-step palletizing of money grass particle
Method.
Background technology
There is the trend increased year by year in the incidence of disease of urolithiasis, and as the first disease of south China each province Urology Surgery
Disease.Although extracorporeal shock wave and PNL, the clinical practice of ureterorenoscope stone-extraction operation in recent years, in clinic
On also achieve larger progress, but the important of Urology Surgery is still the problems such as the recurrence of the residual of postoperative calculus and calculus and is asked
Topic, so the protective agents of new urolithiasis are being researched and developed in countries in the world at present.
Desmodium is Primulaceae Lysimachia plant Lysimachia christinae (Lysimachia christinae Hance), also known as
Christina loosestrife herb, to seat grass, everywhere LUBIANHUANG, Huang etc., desmodium bitter, acid, be slightly cold.Return liver, courage, kidney, bladder warp.Function heat-clearing
Removing toxic substances, diuresis and stone expeling, promoting blood circulation to remove blood stasis.For liver, gall stone, cholecystitis, icterepatitis, stone in urinary system, oedema, bruise damage
Wound, venomous snake bite, malicious mouse and drug poisoning：Purulent inflammation, burn and scald are controlled in external application.The thatched cottage proved recipe transcript of Sichuan hundred according to legend, clearly
For qianlong yearses (1736-1795), there is the record of desmodium treatment " yellow sand walks subcutaneous ulcer ", the application at least having for more than 200 years so far
History.Nearly 50 years, domestic scholars carried out many researchs to the chemical composition of desmodium, pharmacological action and clinical practice.Gold
Money grass Chinese medicine preparation has been used for treating calculi in urinary system, infection and cholecystolithiasis, cholecystitis.
Initial analysis desmodium contain phenolic constituent, flavonoids, glucoside, tannin, volatile oil, amino acid, choline, sterol,
The compositions such as potassium chloride, interior lipid.Wherein flavonoids research comparison go deep into, it is separated go out 10 kinds of compounds.Chinese scientific journal
Report from the ethanol extract of desmodium after petroleum ether degreasing, upper polyamide column, with water and 20%, 50%, 70%, 90%
Ethanol carries out the process such as low pressure column chromatography and gradient elution, obtains six flavone compounds, respectively Quercetin
(Quetcetin), quercetin glucoside, Kaempferol (Kaempferol), Kaempferol galactoside, the glucoside of Kaempferol three etc.,
To the ethanol extract of desmodium by H-103 large pore resin absorption columns, then silica gel column layer folding is carried out, washed with different eluents
It is de-, obtain four kinds of flavone compounds, respectively Kaempferol -3- glycosides, Kaempferol -3- rutinosides.Rhamnocitrin
Diglucoside and afzelin -7- rhamnopyranosyl mouse -1-3- Lee's glucosides etc..Animal experiment proves these compositions
There is an obvious diuresis, the excretion of calcium is reduced in urine, the increase of citric acid excretion, and transaminase and creatinine are without change in blood
Change.Main composition can also make the urinary calculi formation rate of the urinary tract calcinm oxalate calculus animal model as caused by ethylene glycol, activated vitamin D 3
Significantly reduce, and ethylene glycol, activated vitamin D 3 can be mitigated to the detrimental effect of renal function.Prove that its main composition can be reduced
The significant risk factor urinary calcium and the excretion of urine mesoxalic acid that calcic urinary calculi is formed, increase the citric acid of inhibiting factor containing calcium calculus
Excretion, there is the diuresis formed to prevention urinary calculi, having prevents urinary calculi from being formed, the work that especially calcinm oxalate calculus is formed
With the effect with protection renal function.
Existing money grass particle uses wet granulation mode, and the equipment that this granulation mode needs is more, complex procedures,
More manual operations are correspondingly needed, and medicine can be allowed exposed, cause bigger pollution risk.Simultaneously because wet granulation is
First various medicine main and supplementary materials are blended together, then formed section shape fine particle, this granulation mode can cause raw material and
Auxiliary material is excessively fully contacted and reacted, not highly beneficial for some medicines.
The content of the invention
In view of the above-mentioned deficiency of prior art, the technical problems to be solved by the invention are to provide one kind can be simple
The desmodium preparation method of granules of the step granulating of ground one.
Technical scheme is as follows：A kind of Sugarless type desmodium preparation method of granules, it is characterised in that including following
Step：
1) stock up：It is ready for preparing the desmodium medicinal extract, diluent and other auxiliary materials of money grass particle, wherein money
The weight ratio scope of careless medicinal extract and diluent is 20:3.5-20:1.5；
2) desmodium medicinal extract prepares and is incubated：In the attemperator that standby desmodium medicinal extract is encased in, and pass through this
Attemperator controls holding temperature at 40-60 DEG C；
3) equipment regulation and control：It is 25-30Hz by the set of frequency of fluidized drying pelletizer inner blower, trembles between bag time
Every being arranged to 10-20s, tremble a bag number and be arranged to 5-10 times, and be arranged to EAT by the heater on the blower fan
70-130 DEG C, blower fan startup program is opened, by the material heater in fluidized drying pelletizer by material heating-up temperature model
Enclose and be arranged to 40-65 DEG C, and open heating schedule, will be used to spray the nozzle spray of desmodium medicinal extract in fluidized drying pelletizer
Pressure is arranged to 0.2-0.3Mpa, and opens spray procedure；
4) auxiliary material adds, heats and seethed with excitement：The diluent and other auxiliary materials are added in fluidized drying pelletizer,
After adding auxiliary material, allow the auxiliary material of addition to be seethed with excitement in fluidized drying pelletizer mixing 8-15 minutes, while mixing is seethed with excitement, lead to
The fluidized state for the observation window observation auxiliary material crossed on fluidized drying pelletizer, if boiling undermixing, improves blower fan frequency,
If boiled strong, blower fan frequency is reduced；
5) spraying granulating：Detected in real time by the temperature measuring equipment in fluidized drying pelletizer, temperature is read, what is read
When real time temperature is more than or equal in step 3 the material heating-up temperature set, peristaltic pump is opened, and the rotating speed of peristaltic pump is set
In 60-120r/min, peristaltic pump sucks the desmodium medicinal extract in the attemperator, and by being used in fluidized drying pelletizer
It is sprayed downwards in vaporific in the nozzle of sprinkling desmodium medicinal extract, the desmodium medicinal extract of atomization and the auxiliary material knot of suspended state
Close, gradually form particle；
6) lasting spraying：When partial particulate occurs in the material in fluidized drying pelletizer, lasting spraying is initially entered
In the stage, the rotating speed of peristaltic pump is now adjusted, but is no more than 170r/m, atomisation pressure, to tremble bag action frequency constant, and passes through boiling
Observation window on drying and granulating machine observes the fluidized state of material at any time, when the degree deficiency of the boiling of material, by blower fan frequency
Rate increases 2-5Hz, and the time interval of bag is trembled in adjustment, when remaining desmodium medicinal extract is a quarter of total amount, reduces and wriggles
The rotating speed of pump is to being no more than 130r/m；
7) dry：By the set of frequency of blower fan to 50Hz, by adjusting and controlling EAT, by fluidized drying pelletizer
Interior temperature of charge is controlled at 50-70 DEG C, and dries 20-40min, is blown cold by granule materials after the completion of drying and is taken out.
Using above technical scheme, each step mainly occurs in fluidized drying pelletizer in the present invention.Fluidized drying
Granulator is made up of air cleaner, heater, hopper, king-tower, blower fan and the part of control system six.Air cleaner is mainly used
The air opposed into granulator carries out dust ion filter.Heater is mainly used as the heating of air, meets drying process heat
The temperature of wind.Hopper, king-tower are the main bodys of drying machine, and drying process is completed in hopper, king-tower.Blower fan is mainly used as drying
The suction and discharge of process institute required airflow.
In step 1, it is that the weight proportion of desmodium medicinal extract and diluent is scheduled on 20 according to formula:3.5-20:1.5 this
Individual scope, other auxiliary materials use as weight replenishers.Desmodium medicinal extract is placed on attemperator before spraying treatment is carried out
It is interior, and by temperature control between 40-60 DEG C, to ensure that desmodium is leached in a good physical state, be easy to follow-up logical
Cross sprayer unit and carry out atomisation.The auxiliary material material of mixing is pumped into by blower fan, is filtered, then passed through in hopper
Heater heating air reaches technological requirement temperature, by feed hopper bottom airflow-distribution board even into king-tower, makes the auxiliary of mixing
Material material is in hopper and tower in the state seethed with excitement.The moisture content of material evaporation is taken out of by hot blast and obtains drying simultaneously, moisture evaporation
Discharged afterwards with hot blast through cloth envelop collector, while the material fine powder to get on air-flow band is trapped by cloth bag, is returned by trembling bag
Hopper.The auxiliary material material of boiling is in dust suspended state, and trickle auxiliary material dust is combined with the desmodium medicinal extract being atomized, ingredient powder
Dirt constantly adsorbs the desmodium medicinal extract of atomization, then gradually forms particle as the nuclei of condensation.When big arrive of the weight of particle can not
When support suspends in itself, tenesmus is just produced.
The diluent is included in Sionit, mannitol, maltitol, protein sugar, xylitol stevioside and Tagatose
One or more.Using above-mentioned article as diluent and sweetener in the present invention, it is therefore an objective to the mouth of medicine particle can be improved
Sense, increase acceptable degree, while be free of sugar again, can be used for diabetes patient and take, will not damage.
Other described auxiliary materials are one kind or more in filler, flavouring, wetting agent, binder, disintegrant and volatile oil
Kind.In order to reach the purpose of other various auxiliary and drug effect typically in pharmacy, other auxiliary materials can be added.Such as correcting medicine has not
It is subjected to smell and adds flavouring and carry out taste correction, also such as disintegration is absorbed rapidly in stomach in order that obtaining medicine preparation
And add disintegrant.These auxiliary materials are united in the present invention is classified as other auxiliary materials, and its content is not fixed, and it is usually as weight that it, which is combined,
Measure replenishers.
Beneficial effects of the present invention：The present invention is reasonable in design, involved relative to the wet granulation mode of prior art
Number of devices it is less, integration of equipments, automaticity are higher, operation it is easier, avoid medicine in process of production
It is exposed, pollute, while what is also produced is Sugarless type money grass particle, is taken available for diabetes patient.
Embodiment
With reference to embodiment, the invention will be further described：
Embodiment one
A kind of Sugarless type desmodium preparation method of granules, has steps of：
1) stock up：It is ready for preparing the desmodium medicinal extract, diluent and other auxiliary materials of money grass particle, the present embodiment
Middle diluent is mannitol, and is wherein 20 by the weight ratio of desmodium medicinal extract and mannitol:3.5, from disintegrant and rectify
The mixture of taste agent is as other auxiliary materials, to cause overall amount to reach the regulation requirement of country.
2) desmodium medicinal extract prepares and is incubated：In the attemperator that standby desmodium medicinal extract is encased in, and pass through this
Holding temperature is arranged on 40 DEG C by attemperator；
3) equipment regulation and control：It is 25Hz by the set of frequency of fluidized drying pelletizer inner blower, trembles a bag time interval
10s is arranged to, a bag number is trembled and is arranged to 5 times, and EAT is arranged to 70 DEG C by the heater on the blower fan, is opened
Blower fan startup program, material heating temperature range is arranged to 40 DEG C by the material heater in fluidized drying pelletizer,
And heating schedule is opened, the nozzle spray pressure for being used to spray desmodium medicinal extract in fluidized drying pelletizer is arranged to
0.2Mpa, and open spray procedure；
4) auxiliary material adds, heats and seethed with excitement：The diluent and other auxiliary materials are added in fluidized drying pelletizer,
After adding auxiliary material, allow the auxiliary material of addition to be seethed with excitement in fluidized drying pelletizer and mix 8 minutes, while mixing is seethed with excitement, pass through
The fluidized state of observation window observation auxiliary material on fluidized drying pelletizer, if boiling undermixing, improves blower fan frequency, such as
Fruit is boiled strong, then reduces blower fan frequency；
5) spraying granulating：Detected in real time by the temperature measuring equipment in fluidized drying pelletizer, temperature is read, what is read
When real time temperature is more than or equal in step 3 the material heating-up temperature set, peristaltic pump is opened, and the rotating speed of peristaltic pump is set
In 60r/min, peristaltic pump sucks the desmodium medicinal extract in the attemperator, and by being used to spray in fluidized drying pelletizer
The nozzle for spilling desmodium medicinal extract is combined it in vaporific spray, the desmodium medicinal extract of atomization downwards with the auxiliary material of suspended state, by
Gradually form particle；
6) lasting spraying：When partial particulate occurs in the material in fluidized drying pelletizer, lasting spraying is initially entered
In the stage, the rotating speed of peristaltic pump is now adjusted, but is no more than 170r/m, atomisation pressure, to tremble bag action frequency constant, and passes through boiling
Observation window on drying and granulating machine observes the fluidized state of material at any time, when the degree deficiency of the boiling of material, by blower fan frequency
Rate increases 2-5Hz, and the time interval of bag is trembled in adjustment, when remaining desmodium medicinal extract is a quarter of total amount, reduces and wriggles
The rotating speed of pump is to being no more than 130r/m；
7) dry：By the set of frequency of blower fan to 50Hz, by adjusting and controlling EAT, by fluidized drying pelletizer
Interior temperature of charge is controlled at 50 DEG C, and dries 20min, is blown cold by granule materials after the completion of drying and is taken out.
Embodiment two
A kind of Sugarless type desmodium preparation method of granules, has steps of：
1) stock up：It is ready for preparing the desmodium medicinal extract, diluent and other auxiliary materials of money grass particle, the present embodiment
What middle diluent was selected is maltitol, and wherein the weight ratio scope of desmodium medicinal extract and maltitol is 20:2, from viscous
Mixture supplements weight as other auxiliary materials；
2) desmodium medicinal extract prepares and is incubated：In the attemperator that standby desmodium medicinal extract is encased in, and pass through this
Attemperator controls holding temperature at 50 DEG C；
3) equipment regulation and control：It is 27Hz by the set of frequency of fluidized drying pelletizer inner blower, trembles a bag time interval
15s is arranged to, a bag number is trembled and is arranged to 7 times, and EAT is arranged to 100 DEG C by the heater on the blower fan, is opened
Blower fan startup program is opened, material heating temperature range is arranged to 50 by the material heater in fluidized drying pelletizer
DEG C, and heating schedule is opened, the nozzle spray pressure for being used to spray desmodium medicinal extract in fluidized drying pelletizer is arranged to
0.253Mpa, and open spray procedure；
4) auxiliary material adds, heats and seethed with excitement：The diluent and other auxiliary materials are added in fluidized drying pelletizer,
After adding auxiliary material, allow the auxiliary material of addition to be seethed with excitement in fluidized drying pelletizer and mix 12 minutes, while mixing is seethed with excitement, pass through
The fluidized state of observation window observation auxiliary material on fluidized drying pelletizer, if boiling undermixing, improves blower fan frequency, such as
Fruit is boiled strong, then reduces blower fan frequency；
5) spraying granulating：Detected in real time by the temperature measuring equipment in fluidized drying pelletizer, temperature is read, what is read
When real time temperature is more than or equal in step 3 the material heating-up temperature set, peristaltic pump is opened, and the rotating speed of peristaltic pump is set
In 100r/min, peristaltic pump sucks the desmodium medicinal extract in the attemperator, and by being used in fluidized drying pelletizer
The nozzle for spraying desmodium medicinal extract is combined it in vaporific spray, the desmodium medicinal extract of atomization downwards with the auxiliary material of suspended state,
Gradually form particle；
6) lasting spraying：When partial particulate occurs in the material in fluidized drying pelletizer, lasting spraying is initially entered
In the stage, the rotating speed of peristaltic pump is now adjusted, but is no more than 170r/m, atomisation pressure, to tremble bag action frequency constant, and passes through boiling
Observation window on drying and granulating machine observes the fluidized state of material at any time, when the degree deficiency of the boiling of material, by blower fan frequency
Rate increases 2-5Hz, and the time interval of bag is trembled in adjustment, when remaining desmodium medicinal extract is a quarter of total amount, reduces and wriggles
The rotating speed of pump is to being no more than 130r/m；
7) dry：By the set of frequency of blower fan to 50Hz, by adjusting and controlling EAT, by fluidized drying pelletizer
Interior temperature of charge is controlled at 60 DEG C, and dries 30min, is blown cold by granule materials after the completion of drying and is taken out.
Embodiment three
1st, a kind of Sugarless type desmodium preparation method of granules, has steps of：
1) stock up：It is ready for preparing the desmodium medicinal extract, diluent and other auxiliary materials of money grass particle, the present embodiment
Middle diluent is the weight of the mixture of protein sugar and Tagatose, wherein desmodium medicinal extract and protein sugar and the mixture of Tagatose
Ratio range is 20:1.5, using supplement of the filler as weight；
2) desmodium medicinal extract prepares and is incubated：In the attemperator that standby desmodium medicinal extract is encased in, and pass through this
Attemperator controls holding temperature at 60 DEG C；
3) equipment regulation and control：It is 30Hz by the set of frequency of fluidized drying pelletizer inner blower, trembles a bag time interval
20s is arranged to, a bag number is trembled and is arranged to 10 times, and EAT is arranged to 130 DEG C by the heater on the blower fan, is opened
Blower fan startup program is opened, material heating temperature range is arranged to 65 by the material heater in fluidized drying pelletizer
DEG C, and heating schedule is opened, the nozzle spray pressure for being used to spray desmodium medicinal extract in fluidized drying pelletizer is arranged to
0.3Mpa, and open spray procedure；
4) auxiliary material adds, heats and seethed with excitement：The diluent and other auxiliary materials are added in fluidized drying pelletizer,
After adding auxiliary material, allow the auxiliary material of addition to be seethed with excitement in fluidized drying pelletizer and mix 15 minutes, while mixing is seethed with excitement, pass through
The fluidized state of observation window observation auxiliary material on fluidized drying pelletizer, if boiling undermixing, improves blower fan frequency, such as
Fruit is boiled strong, then reduces blower fan frequency；
5) spraying granulating：Detected in real time by the temperature measuring equipment in fluidized drying pelletizer, temperature is read, what is read
When real time temperature is more than or equal in step 3 the material heating-up temperature set, peristaltic pump is opened, and the rotating speed of peristaltic pump is set
In 120r/min, peristaltic pump sucks the desmodium medicinal extract in the attemperator, and by being used in fluidized drying pelletizer
The nozzle for spraying desmodium medicinal extract is combined it in vaporific spray, the desmodium medicinal extract of atomization downwards with the auxiliary material of suspended state,
Gradually form particle；
6) lasting spraying：When partial particulate occurs in the material in fluidized drying pelletizer, lasting spraying is initially entered
In the stage, the rotating speed of peristaltic pump is now adjusted, but is no more than 170r/m, atomisation pressure, to tremble bag action frequency constant, and passes through boiling
Observation window on drying and granulating machine observes the fluidized state of material at any time, when the degree deficiency of the boiling of material, by blower fan frequency
Rate increases 2-5Hz, and the time interval of bag is trembled in adjustment, when remaining desmodium medicinal extract is a quarter of total amount, reduces and wriggles
The rotating speed of pump is to being no more than 130r/m；
7) dry：By the set of frequency of blower fan to 50Hz, by adjusting and controlling EAT, by fluidized drying pelletizer
Interior temperature of charge is controlled at 70 DEG C, and dries 40min, is blown cold by granule materials after the completion of drying and is taken out.
Claims (3)
1. a kind of Sugarless type desmodium preparation method of granules, it is characterised in that comprise the following steps：
1) stock up：It is ready for preparing the desmodium medicinal extract, diluent and other auxiliary materials of money grass particle, wherein desmodium is soaked
The weight ratio scope of cream and diluent is 20:3.5-20:1.5
2) desmodium medicinal extract prepares and is incubated：In the attemperator that standby desmodium medicinal extract is encased in, and pass through the insulation
Device controls holding temperature at 40-60 DEG C；
3) equipment regulation and control：It is 25-30Hz by the set of frequency of fluidized drying pelletizer inner blower, trembles a bag time interval and set
10-20s is set to, a bag number is trembled and is arranged to 5-10 times, and EAT is arranged to by 70- by the heater on the blower fan
130 DEG C, blower fan startup program is opened, is set material heating temperature range by the material heater in fluidized drying pelletizer
40-65 DEG C is set to, and opens heating schedule, will be used to spray the nozzle spray pressure of desmodium medicinal extract in fluidized drying pelletizer
0.2-0.3Mpa is arranged to, and opens spray procedure；
4) auxiliary material adds, heats and seethed with excitement：The diluent and other auxiliary materials are added in fluidized drying pelletizer, added
After auxiliary material, allow the auxiliary material of addition to be seethed with excitement in fluidized drying pelletizer mixing 8-15 minutes, while mixing is seethed with excitement, pass through boiling
The fluidized state of the observation window observation auxiliary material on drying and granulating machine is risen, if boiling undermixing, improves blower fan frequency, if
It is boiled strong, then reduce blower fan frequency；
5) spraying granulating：Detected in real time by the temperature measuring equipment in fluidized drying pelletizer, read temperature, it is real-time what is read
When temperature is more than or equal in step 3 the material heating-up temperature set, peristaltic pump is opened, and the rotating speed of peristaltic pump is arranged on
60-120r/min, peristaltic pump suck the desmodium medicinal extract in the attemperator, and by being used in fluidized drying pelletizer
The nozzle for spraying desmodium medicinal extract is combined it in vaporific spray, the desmodium medicinal extract of atomization downwards with the auxiliary material of suspended state,
Gradually form particle；
6) lasting spraying：When partial particulate occurs in the material in fluidized drying pelletizer, the lasting spraying stage is initially entered,
The rotating speed of peristaltic pump is now adjusted, but is no more than 170r/m, atomisation pressure, to tremble bag action frequency constant, and passes through fluidized drying
Observation window on granulator observes the fluidized state of material at any time, and when the degree deficiency of the boiling of material, blower fan frequency is increased
Add 2-5Hz, the time interval of bag is trembled in adjustment, when remaining desmodium medicinal extract is a quarter of total amount, reduces peristaltic pump
Rotating speed is to being no more than 130r/m；
7) dry：By the set of frequency of blower fan to 50Hz, by adjusting and controlling EAT, by fluidized drying pelletizer
Temperature of charge is controlled at 50-70 DEG C, and dries 20-40min, is blown cold by granule materials after the completion of drying and is taken out.
2. Sugarless type desmodium preparation method of granules according to claim 1, it is characterised in that：The diluent includes mountain
One or more in pears alcohol sugar, mannitol, maltitol, protein sugar, xylitol stevioside and Tagatose.
3. Sugarless type desmodium preparation method of granules according to claim 1, it is characterised in that：Other described auxiliary materials are to fill out
The one or more filled in agent, flavouring, wetting agent, binder, disintegrant and volatile oil.
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| CN108272836A (en) * | 2018-03-08 | 2018-07-13 | 重庆三峡学院 | A kind of desmodium solid tea beverage and preparation method thereof |
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| CN104224867A (en) * | 2014-09-28 | 2014-12-24 | 重庆和平制药有限公司 | Sugarless herba lysimachiae granules and preparation method thereof |
| CN104814988A (en) * | 2015-05-20 | 2015-08-05 | 福州闽海药业有限公司 | Preparation method of indigowoad root granules |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224867A (en) * | 2014-09-28 | 2014-12-24 | 重庆和平制药有限公司 | Sugarless herba lysimachiae granules and preparation method thereof |
| CN104814988A (en) * | 2015-05-20 | 2015-08-05 | 福州闽海药业有限公司 | Preparation method of indigowoad root granules |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272836A (en) * | 2018-03-08 | 2018-07-13 | 重庆三峡学院 | A kind of desmodium solid tea beverage and preparation method thereof |
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