CN106266925A - One treats children's's food stagnation prescription half extractum film garment piece and preparation method thereof - Google Patents

One treats children's's food stagnation prescription half extractum film garment piece and preparation method thereof Download PDF

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CN106266925A
CN106266925A CN201610897087.6A CN201610897087A CN106266925A CN 106266925 A CN106266925 A CN 106266925A CN 201610897087 A CN201610897087 A CN 201610897087A CN 106266925 A CN106266925 A CN 106266925A
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food stagnation
rhizoma
garment piece
children
semen
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赵元英
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Bozhou City Poly Pharmaceutical Sales Co Ltd
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Bozhou City Poly Pharmaceutical Sales Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention discloses one and treat children's's food stagnation prescription half extractum film garment piece and preparation method thereof, it is made up of following component and weight portion thereof: Poria 10 12, the Rhizoma Atractylodis Macrocephalae 30 35, dry Rhizoma Dioscoreae 30 35, Semen Nelumbinis 30 35, Fructus Crataegi 15 17, Radix Glycyrrhizae 15 17, Pericarpium Citri Reticulatae 15 17, Rhizoma Alismatis 16 18, Cortex Magnoliae Officinalis 15 17, SEMEN TSAOKO 16 18, Mel 30 35, Fructus Fragariae Ananssae powder 30 35, apple vinegar 50 55.The one of the present invention treats children's's food stagnation prescription half extractum film garment piece, and anti-moisture absorption, stability are preferable, and contained effective ingredient is administered for diseases such as weakness of the spleen and stomach, spleen benefiting and stimulating the appetite, boosting qi and nourishing yin, the therapy for the treatment of both the principal and secondary aspects of a disease carries out treating children's's food stagnation, and ingredient is safe and reliable, has no side effect.

Description

One treats children's's food stagnation prescription half extractum film garment piece and preparation method thereof
Technical field
The present invention relates to Chinese prescription technical field, particularly relate to one treat children's's food stagnation prescription half extractum film garment piece and Its preparation method.
Background technology
Chinese medicinal granule is extracted concentration by single medicinal material and makes, and is clinically used for replacing decoction pieces to be deployed into decoction, its section The advantages such as, flexible, taking convenience have obtained approving the most widely.Dry granulation has efficiency height, pelletization is not subject to Heat, finished product be difficult to the features such as the moisture absorption, be particularly suitable for Chinese medicinal granule use traditional Chinese medicinal extract powder directly pelletize, supplementary product consumption few Feature.Chinese medicinal granule uses the direct dry granulation of extract powder, and one-shot forming rate generally reaches 50%, after being pelletized by secondary, Major part becomes granule, and production efficiency is high, but, also some kind extract powder stickiness is poor, the most once can not become Grain, needs repeatedly to extrude, and production efficiency is low, and the pellet hardness prepared is big, and solution time is long.Traditional Chinese medicinal extract powder stickiness Greatly, hygroscopicity is strong, it is difficult to molding, is difficult to make granule, and the easy moisture absorption of granule made and being adhered, unstable, for improving tablet Quality, preferably plays its curative effect, plans it and changes system into Film coated tablets." moulding process of Chinese medicine half extractum Film coated tablets is examined Examine " in Zhang Yuan etc. the granulating process of coronary disease plain film is used instead fluidized bed granulation method, and it is pelletized, tabletting and film coating procedure Carrying out systematic study, the big production for Chinese medicine half extractum Film coated tablets provides test basis.Add Pulvis Talci when tabletting always mixes, can show Write the mobility improving granule, meet the technological requirement of tabletting.In granule, moisture is extruded when granule is compressed by punch die To granule surface formed thin film, the thin film of formation can rise lubrication improve pressure transmission thus increase the hardness of tablet. The granule being completely dried is elastic greatly, plasticity is little, it is difficult to be pressed into sheet, and the existence of amount of water can increase the plasticity of friability particle and become Shape, reduces elasticity and strengthens tablet hardness.But the water content of granule is the highest, in tableting processes, both the most glutinous punchings, can affect simultaneously The mobility of granule.The solution of Chinese medical concrete and preparation hygroscopic effect thereof is to ensure that the key that the quality of the pharmaceutical preparations is stable.Different product Planting composition different, hygroscopicity there is also larger difference, and this just requires that pharmacy worker studies in production practices and selects most preferably Production technology, control the relative humidity of workshop and preferable damp-prrof packing, such Chinese medical concrete and preparation thereof simultaneously Sucting wet problem can be readily solved surely.The probability mechanism of traditional Chinese medicinal extract powder moisture absorption includes: existing in medicine can be with pole in hydrone Property light base formed hydrogen bond polar group, activity the most therein is through base；By dividing between hydrone and Chinese medical concrete powder body Sub-intermolecular forces attracts each other, and Water Molecular Adsorption is at Chinese medical concrete powder surface；By capillary attraction effect, water adsorption and It is stored in the hole of powder body；Owing in traditional Chinese medicinal extract powder, chemical substance is usually unformed shape, easily moisture absorption forms hydrate, It is changed into hydration crystal formation by anhydrous crystal forms after absorbing moisture.
It is reported, extract powder poor fluidity, moisture absorption that east virus-clearing capsule extraction process prepares are big.Use microcrystalline cellulose In element, starch and prescription, Radix Scutellariae fine powder is adjuvant, mixes by different proportion with extract powder respectively, and wherein extract powder and starch are 1: The prescription of 1 improves hygroscopicity largely, and its critical relative humidity is 60.5%, so, it is desirable to workshop the wettest Degree controls below 60%, provides theoretical foundation for producing control workshop humidity.At 40 DEG C, the condition of relative humidity 75% Under, study after the Chinese medical concrete that moisture absorption is stronger being made electuary by different auxiliary material, by measuring Moisture percentage and facing Boundary's relative humidity, result shows: the electuary that independent lactose is made as adjuvant, once moisture absorption, can not maintain the granule of electuary Shape.Although the moisture absorption degree of microcrystalline Cellulose is slightly larger than lactose, but easily pelletizes, though granule deliquescing after moisture absorption, remain to maintenance Granular, therefore microcrystalline Cellulose should be first-selected adjuvant for the extractum of moisture absorption.For improving the hygroscopicity of Radix Salviae Miltiorrhizae electuary, investigate respectively Single adjuvant (respectively soluble starch, sucrose, dextrin, lactose) and two kinds of adjuvant (respectively lactose and soluble starch, breasts Sugar and sucrose, lactose and dextrin, lactose and carboxymethyl starch sodium, lactose and mannitol) on its hygroscopic impact.Result table Bright, the moisture absorption degree of single adjuvant order is lactose, sucrose, soluble starch, dextrin, and lactose is most difficult to moisture absorption；Two kinds of adjuvants Moisture absorption degree order be lactose and mannitol, lactose and sucrose, lactose and soluble starch, lactose and dextrin, lactose and carboxylic Methyl starch sodium, lactose and mannitol are most difficult to moisture absorption.Antiphlogistic capsule content starch and PVP, as adjuvant, not only can make Hydroscopicity reduces by 27.3%, and supplementary product consumption also complies with requirement.Ganyanning capsules is full extractum preparation, the easy moisture absorption.Prepare dry extract After, pulverize, add liquid paraffin, mixing, in relative humidity 45% container, investigate hydroscopicity.Result shows, liquid paraffin Consumption is 2% conveniently, adds liquid paraffin and has reached to reduce the effect of moisture absorption.With 40% ethanol extraction leaching of Herba Passiflorae Caeruleae When cream is spray-dried, addition silica gel (Aerosil200), as desiccant adjuvant, has certain anti-hygroscopic effect, And do not affect pharmaceutically active.
Summary of the invention
The object of the invention is contemplated to make up the defect of prior art, it is provided that one treats children's's food stagnation prescription half extractum film Garment piece.
The present invention is achieved by the following technical solutions:
One treats children's's food stagnation prescription half extractum film garment piece, and it is made up of following component and weight portion thereof:
Poria 10-12, Rhizoma Atractylodis Macrocephalae 30-35, dry Rhizoma Dioscoreae 30-35, Semen Nelumbinis 30-35, Fructus Crataegi 15-17, Radix Glycyrrhizae 15-17, Pericarpium Citri Reticulatae 15- 17, Rhizoma Alismatis 16-18, Cortex Magnoliae Officinalis 15-17, SEMEN TSAOKO 16-18, Mel 30-35, Fructus Fragariae Ananssae powder 30-35, apple vinegar 50-55.
Described one treats children's's food stagnation prescription half extractum film garment piece, is made up of the following step:
1), respectively by the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Magnoliae Officinalis, SEMEN TSAOKO cleaning up, mixing adds Mel, apple vinegar and 30- 35 times amount water, soak 30-35 minute, heated and boiled, fire infusion 1.5-2.5 hour of larding speech with literary allusions, and extracting solution is collected by filtration, injects same Water extracts again, merges twice extracting solution, then heats concentration；
2), by Poria, Fructus Crataegi, Semen Nelumbinis, dry Rhizoma Dioscoreae, Fructus Fragariae Ananssae powder mixing pulverizing, extract obtained with step 1 barrel is put into, Startup program, makes material in fluidized state in barrel, sets regulation inlet temperature 85-90 DEG C, atomizing pressure 0.10- 0.12MPa, temperature of charge 51-53 DEG C, compressor flow 120-140 M3•h-1, solution feed pump rotating speed 15-20r min-1, treat material temperature Degree, to 51-53 DEG C, starts spray and binds serosity, control particle growth degree, until obtaining the uniform rounding of size, being suitable for tabletting requirement Granule till；
3), by step 2 gained wet granular in hot air circulation drying oven, dry 25-30 minute in 60-65 DEG C, discharging, cross 14- 20 mesh sieves, are cooled to room temperature；
4), the mixing of step 3 gains is added the micropowder silica gel of mass fraction 1.5-1.7%, 1.5-2% Radix et Rhizoma Nardostachyos volatile oil, 1.5- 1.7% Pulvis Talci mix homogeneously, adding 1.9-2.0 times amount 60-75% ethanol is wetting agent, at the environment of relative humidity 50-60% Under, regulation pressure is 0.45-0.50MPa, carries out tabletting, and every tablet quality controls at 12.5-13g, prepares extractum sheet；
5), by step 4 gained extractum sheet carry out the HPMC film coating that concentration is 5-5.5%, subpackage, seal and preserve.
The invention have the advantage that
The one of the present invention treats children's's food stagnation prescription half extractum film garment piece, and in granule, moisture is when granule is compressed by punch die Be extruded to granule surface formed thin film, the thin film of formation can rise lubrication improve pressure transmission thus increase tablet Hardness, is coated on dry particle surface by process for modifying surface Pulvis Talci, micropowder silica gel and Radix et Rhizoma Nardostachyos volatile oil, thus drops The hygroscopicity of low Chinese medicine extract, improves the bad odor of Chinese medicine extract, improves the stability of traditional medicine volatile oil, and reducing Chinese medicine has The irritation on mucous membrane etc. at effect position, and by controlling relative humidity, effectively to prevent granule moisture absorption from causing the glutinous punching of tabletting, thin film Garment piece moisture absorption, causes the problems such as clothing film deliquescing.
The one of the present invention treats children's's food stagnation prescription half extractum film garment piece, dry Rhizoma Dioscoreae in side, sweet, flat, enters spleen, lung, kidney Warp, spleen benefiting and stimulating the appetite, boosting qi and nourishing yin；The Rhizoma Atractylodis Macrocephalae, sweet, bitter, tepor, enter spleen, stomach warp, invigorating the spleen and replenishing QI, invigorating the spleen and regulating the stomach, work collaborative with Rhizoma Dioscoreae For splenoasthenic spontaneous sweating, particularly treatment children's's inappetence after being ill, weak spontaneous perspiration；Pericarpium Citri Reticulatae, bitter in the mouth, pungent, warm, enter spleen, Liver Channel, reason Gas spleen invigorating, drying dampness to eliminate phlegm, cure mainly distension and fullness of the chest and abdomen, dyspepsia, be equipped with Cortex Magnoliae Officinalis, the abdominal distention that disappears is suffered from abdominal pain；Fructus Crataegi, property is sour, sweet, tepor, Return spleen, stomach, Liver Channel, promoting digestion and invigorating the stomach, for adjuvant drug, make full side mend and oiliness；Fructus Fragariae Ananssae powder is used as medicine and can block bitterness sense, strengthens edible Property, its acid being conducive to is whetted the appetite simultaneously, aid digestion.
Detailed description of the invention
One treats children's's food stagnation prescription half extractum film garment piece, and it is made up of following component and weight portion thereof:
Poria 10, the Rhizoma Atractylodis Macrocephalae 30, dry Rhizoma Dioscoreae 30, Semen Nelumbinis 30, Fructus Crataegi 15, Radix Glycyrrhizae 15, Pericarpium Citri Reticulatae 15, Rhizoma Alismatis 16, Cortex Magnoliae Officinalis 15, SEMEN TSAOKO 16, Mel 30, Fructus Fragariae Ananssae powder 30, apple vinegar 50.
Described one treats children's's food stagnation prescription half extractum film garment piece, is made up of the following step:
1), respectively by the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Magnoliae Officinalis, SEMEN TSAOKO cleaning up, mixing adds Mel, apple vinegar and 30 Times amount water, soaks 30 minutes, heated and boiled, fire infusion 1.5 hours of larding speech with literary allusions, and extracting solution is collected by filtration, injects same water and again carry Take, merge twice extracting solution, then heat concentration；
2), by Poria, Fructus Crataegi, Semen Nelumbinis, dry Rhizoma Dioscoreae, Fructus Fragariae Ananssae powder mixing pulverizing, extract obtained with step 1 barrel is put into, Startup program, makes material in fluidized state in barrel, sets regulation inlet temperature 85 DEG C, atomizing pressure 0.10MPa, material temperature Spend 51 DEG C, compressor flow 120 M3•h-1, solution feed pump rotating speed 15r min-1, treat that temperature of charge, to 51 DEG C, starts spray and binds serosity, Control particle growth degree, until obtaining the uniform rounding of size, being suitable for the granule that tabletting requires；
3), by step 2 gained wet granular in hot air circulation drying oven, it is dried 25 minutes in 60 DEG C, discharging, crosses 14 mesh sieves, cold But to room temperature；
4), the mixing of step 3 gains is added the micropowder silica gel of mass fraction 1.5%, 1.5% Radix et Rhizoma Nardostachyos volatile oil, 1.5% Pulvis Talci Mix homogeneously, adding 1.9 times amount 60% ethanol is wetting agent, and in the environment of relative humidity 50%, regulation pressure is 0.45MPa, carries out tabletting, and every tablet quality controls at 12.5g, prepares extractum sheet；
5), by step 4 gained extractum sheet carry out the HPMC film coating that concentration is 5%, subpackage, seal and preserve.

Claims (2)

1. treatment children's's food stagnation prescription half extractum film garment piece, it is characterised in that it is by following component and weight portion system thereof Become:
Poria 10-12, Rhizoma Atractylodis Macrocephalae 30-35, dry Rhizoma Dioscoreae 30-35, Semen Nelumbinis 30-35, Fructus Crataegi 15-17, Radix Glycyrrhizae 15-17, Pericarpium Citri Reticulatae 15- 17, Rhizoma Alismatis 16-18, Cortex Magnoliae Officinalis 15-17, SEMEN TSAOKO 16-18, Mel 30-35, Fructus Fragariae Ananssae powder 30-35, apple vinegar 50-55.
One the most according to claim 1 treats children's's food stagnation prescription half extractum film garment piece, it is characterised in that be by following Step is made:
1), respectively by the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Cortex Magnoliae Officinalis, SEMEN TSAOKO cleaning up, mixing adds Mel, apple vinegar and 30- 35 times amount water, soak 30-35 minute, heated and boiled, fire infusion 1.5-2.5 hour of larding speech with literary allusions, and extracting solution is collected by filtration, injects same Water extracts again, merges twice extracting solution, then heats concentration；
2), by Poria, Fructus Crataegi, Semen Nelumbinis, dry Rhizoma Dioscoreae, Fructus Fragariae Ananssae powder mixing pulverizing, extract obtained with step 1 barrel is put into, Startup program, makes material in fluidized state in barrel, sets regulation inlet temperature 85-90 DEG C, atomizing pressure 0.10- 0.12MPa, temperature of charge 51-53 DEG C, compressor flow 120-140 M3•h-1, solution feed pump rotating speed 15-20r min-1, treat material temperature Degree, to 51-53 DEG C, starts spray and binds serosity, control particle growth degree, until obtaining the uniform rounding of size, being suitable for tabletting requirement Granule till；
3), by step 2 gained wet granular in hot air circulation drying oven, dry 25-30 minute in 60-65 DEG C, discharging, cross 14- 20 mesh sieves, are cooled to room temperature；
4), the mixing of step 3 gains is added the micropowder silica gel of mass fraction 1.5-1.7%, 1.5-2% Radix et Rhizoma Nardostachyos volatile oil, 1.5- 1.7% Pulvis Talci mix homogeneously, adding 1.9-2.0 times amount 60-75% ethanol is wetting agent, at the environment of relative humidity 50-60% Under, regulation pressure is 0.45-0.50MPa, carries out tabletting, and every tablet quality controls at 12.5-13g, prepares extractum sheet；
5), by step 4 gained extractum sheet carry out the HPMC film coating that concentration is 5-5.5%, subpackage, seal and preserve.
CN201610897087.6A 2016-10-14 2016-10-14 One treats children's's food stagnation prescription half extractum film garment piece and preparation method thereof Pending CN106266925A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111467457A (en) * 2020-03-04 2020-07-31 湖南康尔佳制药股份有限公司 Traditional Chinese medicine composition for treating infantile indigestion, preparation method and application

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111467457A (en) * 2020-03-04 2020-07-31 湖南康尔佳制药股份有限公司 Traditional Chinese medicine composition for treating infantile indigestion, preparation method and application

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