WO2015018123A1

WO2015018123A1 - Traditional chinese medicine preparation for reducing blood sugar and preparation method thereof

Info

Publication number: WO2015018123A1
Application number: PCT/CN2013/085091
Authority: WO
Inventors: 田艺儿
Original assignee: Tian Yi Er
Priority date: 2013-08-09
Filing date: 2013-10-12
Publication date: 2015-02-12
Also published as: CN104027652B; CN103386040A; CN104027652A

Abstract

Disclosed is a traditional Chinese medicine preparation for reducing blood sugar and the preparation method thereof. The preparation is a composite liquid preparation prepared from pure water, Radix rehmanniae recens, the root bark of Morus alba, Cortex Lycii Radicis, corn stigma, Radix trichosanthis, Coptis chinensis, Epimedium, acanthopanax, Rhizoma polygonati, Rhodiola rosea, Rhizoma Gastrodiae, Fructus Lycii, Szechwan lovage rhizome, Rhizoma Anemarrhenae, inula flower, ginseng, white sugar, and 65% ethanol solution through processes such as pulverizing, boiling, mixing and stirring. Its effect of reducing blood sugar is obvious and stable, and it is also non-toxic, has no side effects, and the preparation process thereof is simple and easy to perform.

Description

Blood sugar lowering traditional Chinese medicine preparation and preparation method thereof

The invention relates to a traditional Chinese medicine preparation for lowering blood sugar, in particular to a traditional Chinese medicine preparation for reducing blood sugar and a preparation method thereof. Background technique

The sugar in human blood is called blood sugar. In most cases, it is glucose. Sugar is one of the essential nutrients of the human body. Most of the energy of cells in the human body comes from glucose. People eat cereals, vegetables, etc. After the digestive system is converted into glucose into the blood and transported to the whole body as a source of energy, blood sugar must be maintained at a certain level to maintain the needs of various organs and tissues. Normal people have a fasting blood glucose concentration of 4. 1-6. Ommol/L, and a fasting blood glucose concentration of more than 6. 0 mmol/L is called hyperglycemia. At this time, a part of glucose is excreted in the urine, which is diabetes.

With the gradual improvement of people's living standards, there are more and more people with diabetes. Diabetes is a disease that is difficult to cure. Patients need long-term medication and diet control. The common manifestations of diabetes are polyuria, polydipsia, and more food. , weight loss and other performance, that is, "three more than one less" symptoms, and diabetes is very likely to cause cardiovascular disease, kidney disease, neuropathy and other complications.

At present, the clinical use of hypoglycemic drugs, only a few drugs such as insulin, and only effective in injection, there is no drug that can completely cure diabetes, and more drugs that lower blood sugar, but also regulate blood sugar, Moreover, these drugs have certain limitations and adverse reactions, which may lead to side effects such as hypoglycemia and lactic acidosis. Therefore, it is imperative to find a safe, effective and no side-effect hypoglycemic drug.

The object of the present invention is to provide a traditional Chinese medicine preparation for preventing and reducing hyperglycemia by combining the traditional Chinese and Western medicine technology with the above-mentioned deficiencies, and in particular to provide such a traditional Chinese medicine preparation and a preparation method thereof. The invention has obvious effects of lowering blood sugar, and is non-toxic, has no side effects, and has stable effects, and the preparation process is simple and easy.

The technical solution of the present invention is as follows:

The preparation of the invention is pure water, rehmannia root, mulberry white skin, earth bone skin, corn mustard, trichosanthin, berberine, yinyanghuo, acanthopanax, huangjing, rhodiola, gastrodia elata, medlar, chuanxiong, and zhimu, A liquid preparation of a composition prepared by spinning flowers, ginseng, white sugar and 65% ethanol solution, wherein the mass ratio of each component is:

Pure water 4000-8000g Rehmannia 10-30g Mulberry white 20-40g Bone skin 20-40g Corn must 25-35g Trichosanthin 20-30g Coptis 15-25g Hawthorn 20-30g Acanthopanax 20-30g Rhizome 20-30g Red Sedum 20-30g Gastrodia 30-40g Hazelnut 30-40g Chuanxiong 20-30g Zhimu 20-30g Rotary flower 20-35g Ginseng 10-20g White sugar 20-30g

65% ethanol solution 15-30g.

In order to obtain better effects, the preferred raw material quality ratio of the present invention is pure water 5000-8000g rehmannia 10 mulberry white 20-30g ground bone 20-30g corn must 25-30g trichosanthes 20-25g Coptis 15-20g Hawthorn 20_25g Acanthopanax 20_25g Rhizome 20-25g Rhodiola 20-25g Gastrodia 30-35g Hazelnut 30-35g Chuanxiong 20-25g Zhimu 20-25g Rotary flower 20-30g Ginseng 10_20g Sugar 20-30g Of course, in order to obtain further good effects, the present invention may also preferably be used as a raw material quality with purified water 6000g rehmannia 15g mulberry white 25g

Ground bone 25g corn must 25g small pollen 20g

Coptis 15g Hawthorn 20g Acanthopanax 20g

Huang Jing 25g Rhodiola 20g Gastrodia 30g

Scorpion 30g Chuanxiong 20g Zhimu 20g

Rotary flower 25g ginseng 15g white sugar 30g

65% ethanol solution 20g _c

The preparation method of the above hypoglycemic traditional Chinese medicine preparation comprises the following steps:

1), the raw rehmannia, mulberry white, ground bone, corn mustard, trichosanthin, berberine, yinyanghu, acanthopanax is proportioned well, crushed by a pulverizer and passed through a 80 mesh sieve, then at 50-70 ° C is dried at high temperature, and then naturally dried to room temperature for use;

2). Add the powder mixture of Radix Rehmanniae, Mulberry White, Earth Bone Skin, Corn Mustard, Trichosanthes, Coptis, Epimedium, and Acanthopanax in the above steps, add it to pure water for three times, and add 10 times the amount of water for the first time. Fry for half an hour, add 5 times the amount of water for 20 minutes, add 5 times the amount of water for 10 minutes, then combine the decoction and filter, set aside; 3), Huang Jing, Rhodiola, Tianma, Gardenia, Chuanxiong, Zhimu, Rotary Flower, Ginseng are proportioned well, crushed by a pulverizer and passed through a 80 mesh sieve, and then at a high temperature of 50-70 °C Dry, then naturally dry to room temperature for use;

4) Add the above powder mixture of Polygonatum, Rhodiola, Tianma, Gardenia, Chuanxiong, Zhimu, Rotary Flower and Ginseng to 10 times the amount of purified water for half an hour, then take the decoction and filter it. ;

5), at room temperature, the decoction obtained in the above step 2) and step 4), and added 65% ethanol solution and stirred uniformly to form a solution of the traditional Chinese medicine composition solution;

6), the preparation of the traditional Chinese medicine composition solution in the above step 5) is added to the white sugar, and stirred for 5 minutes to obtain.

The preparation of the above-mentioned traditional Chinese medicine composition solution can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better. The theoretical basis of the present invention is: Rehmannia glutinosa, which is the root of the plant of the Scrophulariaceae plant. Sweet, bitter, cold, into the heart, liver, kidney, can be used to cure yin deficiency fever, thirst, vomiting blood, blood stasis, blood collapse, irregular menstruation, fetal movement, constipation, vaginal constipation, etc. It has curative effect and can inhibit experimental hyperglycemia. Its hypoglycemic component is emodin. In combination with other traditional Chinese medicines of the invention, the curative effect is remarkable. Mulberry white skin, the root bark of the mulberry plant. Mainly produced in Anhui, Henan, Zhejiang, Jiangsu, Hunan and other places. The effect is diarrhea and asthma, and the water is swollen. For lung heat cough, facial edema, urinary adverse symptoms. Researchers separated from mulberry white skin in the 1970s

Moranoline, and confirmed that it has hypoglycemic effect, and some people separated from the mulberry white skin 4%。 The blood sugar substance moran A, it is a glycoprotein, molecular weight of about 7. 5x10', protein part accounted for 57.4%. The experiment confirmed that moran A has a dose-dependent hypoglycemic effect on alloxan-induced hyperglycemic mice. If the relative blood glucose level of the hyperglycemia group is 100%, lnor; 1ηΑ3, 10, 30m/kg, 7h after blood glucose The levels were reduced to 61%, 38%, and 34%, respectively, and after 77h, they were 77%, 66%, and 49%. The study found that the compound mulberry white liquor concentrate (30 red kg) and medium (15g/kg) dose group Alloxan-induced diabetes in mice has a significant hypoglycemic effect and a certain hypoglycemic effect on glucocorticulose. The ground bone is the root bark of the Solanaceae plant. Can be used as medicine, cold, sweet. It has the effects of cooling blood and removing phlegm, clearing the lungs and reducing fire. Pharmacological studies have shown that the bone skin has obvious blood pressure lowering and lowering blood sugar. Give the rabbit a bone decoction, first increase the blood sugar for a short time, and then reduce it for a long time. Corn, corn must be the style and stigma of the gramineous plant, also known as jade, mustard, sweet, flat, stomach, gallbladder, kidney, diuretic, swelling, heat, blood pressure and blood sugar . Indications for diabetes, thirst, and polyuria. Trichosanthin, sweet and bitter, sour and sour, return to the lung and kidney, have the effect of thirst, benefit the stomach and reduce the fire and dryness. China's medical book ancient book "The Classic" 曰: The main thirst, body heat, trouble, heat, make up the virtual. Trichosanthin is often associated with Zhimu, Yam, Ophiopogon japonicus, Scorpion, and Astragalus, and treats yin deficiency type diabetes. Coptis, a perennial herb, belongs to the genus Ranunculus. Coptis is bitter, cold, and non-toxic. Heart, spleen, stomach, liver, gallbladder, large intestine. According to clinical reports, the inclusion of berberine in the treatment of sugar Urine can significantly reduce blood sugar, and berberine decoction can reduce blood sugar in normal mice and alloxan-induced diabetic rats. Experiments have shown that the hypoglycemic mechanism of berberine does not affect the secretion and release of insulin, nor does it affect the number and affinity of insulin receptors in hepatocytes, but rather produces hypoglycemic effects by inhibiting gluconeogenesis and promoting glycolysis. Hawthorn, sour, simmer, lukewarm. Liver, kidney, can replenish liver and kidney, astringent and solid, sedative and urinary, stop with collapse, antiperspirant, in addition to thirst, for waist and knee pain, dizziness, tinnitus, forgetful nocturnal essence, enuresis and frequent urination The uterine bleeding is not adjusted, the sweat is collapsed, and the internal heat is thirsty. Acanthopanax senticosus, Weixin, bitter, slightly sweet, warm, return to the liver, kidney. The function is rheumatism, liver and kidney, strong bones and muscles, blood circulation, attending wind and cold dampness, waist and knee pain, weak bones, slow movement, weak body, bruises, fractures, edema, athlete's foot, genital itching, etc. In combination with other traditional Chinese medicines of the invention, the blood sugar lowering effect is obvious. Huang Jing, also known as tiger ginger, chicken head ginseng. It is a dried rhizome of Liliaceae, such as Huangjing, Huangjing or Duohuahuang. The yellow essence is sweet and flat. Return to the lungs, spleen, kidney. It can nourish the kidney and moisten the lungs, and replenish the spleen Rhodiola, perennial herb, 10-20 cm high. The roots are thick, conical, fleshy, brownish yellow, with roots and necks with most fibrous roots. Rhodiola is the dry root and rhizome of Rhodiola rosea. The effect and function of Rhodiola is to nourish the kidney, qi and nourish the blood. There are blood circulation to stop bleeding, clearing the lungs and relieving cough, relieving heat, and stopping the effects. The side effects of Rhodiola have not been found. Gastrodia elata, a perennial herb, is distributed in most parts of the country. Its dry tubers, also known as gastrodia elata, are commonly used and more expensive traditional Chinese medicines. They are clinically used for headache, dizziness, limb numbness, convulsions in children, epilepsy, convulsions, tetanus, etc., and can be used for liver and yang. Headache, dizziness and other symptoms. Scorpion, liver, kidney, lung. The scorpion is not greasy, and it has the functions of nourishing yin and tonifying the kidney, benefiting the eyesight, promoting thirst, yin and yang. It is compatible with Schisandra, Polygonatum and Yuanshen. It is suitable for those who are deficient in liver and kidney, and can improve the symptoms of diabetes. Chuanxiong, a kind of traditional Chinese medicine plant, is often used for promoting blood circulation, relieving pain and relieving pain. It is mainly cultivated in Sichuan, Yunnan, Guizhou, Guangxi, Hubei and other places. Chuanxiong Xin Wenxiang dry, go without keeping, can not only disperse, up to the dome; and into the blood, down to blood. It has a wide-ranging effect on blood stasis, which is suitable for blocking blood stasis and various diseases. It has good qi and pain, and it has good effect. It can cure head wind headache, rheumatism and pain. In the past, it was said that Chuanxiong was a gas medicine in the blood, and it was said that it had functions such as disintegration, depression, accessibility, and pain relief. Zhimu, this product is the dry rhizome of the monocotyledonous lily family, the effect of clearing heat and purging fire, Shengjin Runzao. Clearing heat and purging fire, Shengjin Runzao. For exogenous fever, high fever and polydipsia, lung heat dry cough, bone steaming hot flashes, internal heat and thirst, intestinal dry constipation. Rotating flowers, also known as sedge grass, shamrock. Herbs perennial, stems with longitudinal edges, green or microstriped purplish red. Leaves alternate, elliptic, elliptical-lanceolate or narrowly oblong. The heads are few or many, terminal, arranged in an umbrella-like shape. The flowers are salty, warm, and slightly toxic. They are used to eliminate phlegm, qi, soft and water. Ginseng, perennial herb, hi-smooth, humid climate, mostly grown in coniferous and broad-leaved mixed forests or mixed forests with low temperature difference between day and night, 500~1100 meters above sea level. Ginseng can promote the blood sugar lowering of experimental animals, and can reduce the increase of diabetes and blood lipids and weakness symptoms. Clinical reports of ginseng extract have a therapeutic effect on early mild diabetes, which reduces urine sugar and lowers blood glucose by 40 mg. After stopping the drug, the effect can still last for more than 2 weeks.

65% ethanol solution contains alcohol. Liquor is known as "the longest of 100 medicines". The liquor is stable, safe and effective, and because alcohol is a good semi-polar organic solvent, the various active ingredients of traditional Chinese medicine are soluble. Among them, the medicine exerts its effectiveness by means of alcohol and alcohol to help the drug, and improves the therapeutic effect. Diabetes is caused by insufficient insulin secretion and hyperglycemia, and Western medicine currently has no particularly good treatment for diabetes. It is called incurable disease. However, traditional Chinese medicines have very unique treatments for diabetes. For example, the combination of these drugs has a triple action, which is both a blood glucose inhibitor and an insulin sensitizer, and at the same time enhances insulin receptor function, and the effect is stable. The preparation is safe and has no toxic side effects. It is suitable for long-term use. It does not need to be dieted. It is not necessary to take any other hypoglycemic drugs. It can be taken alone. It can effectively protect the islets, lower blood sugar and improve immunity. At present, Western medicine also treats hyperglycemia. The regulation of blood sugar can not be started from the conditioning of human body function, while the effect of traditional Chinese medicine is moderate, and the effect of stabilizing blood sugar is better. The invention is especially suitable for patients with early and middle-aged hyperglycemia. Clinical Experiment 1: 1) Observation time: In the case where the technical solution of the present invention has not been disclosed, the three months from January 2013 to March 2013 are selected.

2), Observed: 10 cases of diabetes were selected in Shenzhen Hospital of Guangdong Province: 5 males and 5 females; age: 5 cases of 45-55 years old, 5 cases of 55-75 years old; Occupation: 5 cases of private business owners , 5 retirees. Course of disease: The fasting blood glucose concentration in the morning is not less than 11. 6 匪 ol / L, more urine, dry skin, dehydration, thirst, nausea, vomiting and other obvious symptoms.

3), How to use: The oral liquid of the preparation of the present invention is taken 1 hour after the meal, 3 times a day, 300 ml each time, 1 month is a course of treatment, and two courses are observed as therapeutic effects.

4), observation effect:

After the two consecutive treatments, the blood glucose was measured on a fasting basis, 4 patients fell to no more than 9. Ommol / L, 3 cases fell to not more than 8. Ommol / L, 3 cases fell to no more than 8. 5mmol /L. After 7 days of withdrawal, there was no obvious rebound, blood sugar was stable, urine output was reduced, skin dryness was improved, and symptoms such as nausea and vomiting were not obvious.

Clinical trial 2:

1) Observation time: In the case where the technical solution of the present invention has not been disclosed, the three months from April 2013 to June 2013 are selected.

2), Observed: 10 cases were selected in Futian District Hospital of Shenzhen, Guangdong Province: 6 males and 4 females; age: 55-65 years old 5 cases, 65-75 years old 5 cases; Occupation: served as a post leader There were 5 cases of diabetes-type civil servants and 5 cases of diabetic ordinary retired civil servants. Course of disease: Early morning fasting blood glucose concentration is not lower than 12. 5 mmol / L, more urine, dry skin, dehydration, thirst, nausea, vomiting and other obvious symptoms.

3), How to use: Take the oral liquid of the preparation of the present invention 1 hour after the meal, 3 times a day Times, each time 300ml, 1 month for a course of treatment, two courses of treatment as a therapeutic effect.

4), observation effect:

After the two consecutive treatments, the blood glucose was measured on a fasting, 2 patients fell to no more than 9. Ommol / L, 3 cases fell to not more than 8. Ommol / L, 5 cases fell to no more than 8. 5mmol /L. After 7 days of withdrawal, there was no obvious rebound, blood sugar was stable, urine output was reduced, skin dryness was improved, and symptoms such as nausea and vomiting decreased.

In combination with the above clinical data and the theoretical basis of the present invention, the beneficial effects of the present invention are as follows: the preparation prepared by the invention has obvious hypoglycemic effect, is non-toxic, has no side effects, is stable in effect, and has a simple and easy preparation process. Concrete implementation

The present invention will be described in detail below with reference to the embodiments:

Example 1:

Pure water 4000g rehmannia 10g mulberry white 20g

Ground bone 20g corn must 25g three-dimensional powder 20g

Coptis 15g Hawthorn 20g Acanthopanax 20g

Huang Jing 20g Rhodiola 20g Gastrodia 30g

Gardenia 30g Chuanxiong 20g Zhimu 20g Rotary flower 20g ginseng 10g white sugar 20g

155% ethanol solution 15g.

2). Add the powder mixture of Radix Rehmanniae, Mulberry White, Earth Bone Skin, Corn Mustard, Trichosanthes, Coptis, Epimedium, and Acanthopanax in the above steps, add it to pure water for three times, and add 10 times the amount of water for the first time. Fry for half an hour, add 5 times the amount of water for 20 minutes, add 5 times the amount of water for 10 minutes, then combine the decoction and filter, set aside;

3), Huang Jing, Rhodiola, Tianma, Gardenia, Chuanxiong, Zhimu, Rotary Flower, Ginseng are proportioned well, crushed by a pulverizer and passed through a 80 mesh sieve, and then at a high temperature of 50-70 °C Dry, then naturally dry to room temperature for use;

The prepared Chinese medicine composition solution preparation can be used for oral administration, and if it can be consumed once in the morning and evening and long-term drinking, the effect is better. Example 2:

The preferred raw material quality of the present invention is (g):

Pure water 8000g Rehmannia 30g Mulberry white 40g Bone skin 40g Corn must 35g Trichosanthin 30g Coptis 25g Hawthorn 30g Acanthopanax 30g Huangjing 30g Rhodiola 30g Tianma 40g Hazelnut 40g Chuanxiong 30g Zhimu 30g Cyclobalanopsis 35g Ginseng 20g White sugar 30g

155% ethanol solution 15g.

The preparation method is as in Example 1.

Example 3:

The preferred raw material quality of the present invention is (g):

Pure water 5000g Rehmannia 15g Mulberry white 25g Bone skin 25g Corn must 30g Trichosanthin 25g Coptis 20g Hawthorn 25g Acanthopanax 25g Huangjing 25g Rhodiola 25g Tianma 35g Hazelnut 35g Chuanxiong 25g Zhimu 25g Rotary flower 25g Sugar 25g 65 20% ethanol solution,

The preparation method is as in Example 1.

Example 4:

The preferred raw material quality of the present invention is (g): Pure water 6000g Rehmannia 20g Mulberry white 30g Ground bone 30g Corn must 35g Trichosanthin 30g Coptis 25g Hawthorn 30g Acanthopanax 30g Huangjing 30g Rhodiola 30g Tianma 35g Hazelnut 35g Chuanxiong 30g Zhimu 30g Rotary flower 30g Ginseng 20g White sugar 30g

65% ethanol solution 25g.

The preparation method is as in Example 1.

Example 5

The preferred raw material quality of the present invention is (g):

Pure water 7000g Rehmannia root 10g Mulberry white skin 20g Ground bone skin 20g Corn must 25g Trichosanthin 20g Coptis 25g Hawthorn 30g Acanthopanax 30g Huangjing 30g Rhodiola 30g Tianma 30g Hazelnut 30g Chuanxiong 20g Zhimu 20g Rotary flower 35g Ginseng 20g White sugar 20g

65% ethanol solution 30g.

The preparation method is as in Example 1.

Example 6:

The preferred raw material quality of the present invention is (g):

Pure water 4500g Rehmannia root 12g Mulberry white skin 28g Ground bone skin 28 Corn must 28g Trichosanthin 26g Coptis 18g Hawthorn 22g Acanthopanax 22g

Huang Jing 22g Rhodiola 22g Tianma 38g

Scorpion 38g Chuanxiong 21g Zhimu 21g

Rotary flower 23g ginseng 12g white sugar 28g

65% ethanol solution 18g.

The preparation method is as in Example 1.

The above embodiments are only a few of the various embodiments of the present invention. For example, if the formula is increased or decreased according to the ratio in the technical solution, the therapeutic effect of the hypoglycemic preparation prepared is not affected, and will also fall on It is within the scope of the claims of the present invention.

Claims

claims

1. A hypoglycemic traditional Chinese medicine preparation, characterized in that the preparation of the present invention is composed of purified water, rehmannia glutinosa, mulberry bark, rehmannia bark, corn silk, trichosanthes, coptis, epimedium, acanthopanax, polygonatum, and red root. A composition liquid preparation prepared from sedum, gastrodia, wolfberry, Ligusticum chuanxiong, anemarrhena, inula, ginseng, white sugar and 65% ethanol solution, in which the mass ratio of each component is: Purified water 4000-8000g Rehmannia glutinosa 10 Mulberry bark 20-40g Digupi 20-40g Corn silk 25-35g Trichosanthes 20-30g Coptis 15-25g Dogwood 20-30g Acanthopanax 20-30g Polygonatum 20-30g Rhodiola rosea 20-30g Gastrodia elata 30-40g Lycium barbarum 30-40g, Ligusticum chuanxiong 20-30g, Anemarrhena 20-30g, Inula 20-35g, ginseng 10-20g, white sugar 20-30g

65% ethanol solution 15-30g.

2. The hypoglycemic traditional Chinese medicine preparation according to claim 1, further characterized in that the mass ratio of each component is:

Purified water 5000-8000g Rehmannia glutinosa 10-20g Mulberry bark 20-30g Digupi 20-30g Corn silk 25-30g Trichosanthes 20-25g Coptis 15-20g Dogwood 20-25g Acanthopanax 20_25g Polygonatum 20-25g Rhodiola rosea 20-25g Gastrodia elata 30-35g Lycium barbarum 30-35g Ligusticum chuanxiong 20-25g Anemarrhena 20-25g Inula 20-30g Ginseng 10_20g White sugar 20-30g

65% ethanol solution 15-25g ₍

3. The hypoglycemic Chinese medicine preparation according to claim 1 or 2, further characterized by: The mass ratio of each component is:

Purified water 6000g Rehmannia glutinosa 15g Mulberry bark 25g

Digupi 25g corn silk 25g trichosanthin 20g

Coptis 15g, Cornus officinalis 20g, Acanthopanax 20g

Polygonatum 25g Rhodiola rosea 20g Gastrodia elata 30g

Wolfberry 30g, Chuanxiong 20g, Anemarrhena 20g

Inula 25g Ginseng 15g Sugar 30g

65% ethanol solution 20g.

4. A method for preparing a hypoglycemic traditional Chinese medicine preparation, which is characterized in that it includes the following

1). Mix raw rehmannia glutinosa, mulberry bark, rehmannia bark, corn silk, trichosanthes, coptis, epimedium, and acanthopanax in proportion, crush it in a crusher and pass through an 80-mesh sieve, and then grind it at 50-70° Dry at high temperature of C, and then naturally air to room temperature for later use;

2). Add the powder mixture of rehmannia glutinosa, mulberry bark, rehmannia bark, corn silk, trichosanthes, coptis, epimedium, and acanthopanax in the above steps to pure water and cook three times. For the first time, add 10 times the amount of water. Decoct for half an hour, add 5 times the amount of water for the second time and decoct for 20 minutes, add 5 times the amount of water for the third time and decoct for 10 minutes, then combine the decoctions and filter, set aside;

3). Mix Polygonatum, Rhodiola rosea, Gastrodia elata, Lycium barbarum, Ligusticum chuanxiong, Anemarrhena, Inula and ginseng in proportion, crush it through a crusher and pass through an 80 mesh sieve, and then grind it at a high temperature of 50-70°C. Dry, then let it air to room temperature for later use;

4). Add the above-mentioned powder mixture of Polygonatum, Rhodiola rosea, Gastrodia elata, Lycium barbarum, Ligusticum chuanxiong, Anemarrhena, Inula and ginseng into 10 times the amount of purified water and boil for half an hour, then take the decoction. And filter, set aside;

5), at room temperature, mix the decoction obtained in the above steps 2) and 4), add 65% ethanol solution and stir evenly to form a Chinese medicine composition solution preparation; 6), mix the decoction obtained in the above step 5) The Chinese medicine composition solution preparation can be prepared by adding white sugar and stirring for 5 minutes. The prepared Chinese medicine composition solution preparation can be taken orally. If it can be drunk once in the morning, noon and evening and for a long time, the effect will be better.