CN106474266A - A kind of temperature compensation QI and blood prescription half extractum film garment piece and preparation method thereof - Google Patents

A kind of temperature compensation QI and blood prescription half extractum film garment piece and preparation method thereof Download PDF

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Publication number
CN106474266A
CN106474266A CN201610897093.1A CN201610897093A CN106474266A CN 106474266 A CN106474266 A CN 106474266A CN 201610897093 A CN201610897093 A CN 201610897093A CN 106474266 A CN106474266 A CN 106474266A
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radix
temperature compensation
blood
garment piece
extractum
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赵元英
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Bozhou City Poly Pharmaceutical Sales Co Ltd
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Bozhou City Poly Pharmaceutical Sales Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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Abstract

The invention discloses a kind of temperature compensation QI and blood prescription half extractum film garment piece and preparation method thereof, it is made up of following components and its weight portion：Radix Rehmanniae Preparata 13 15, Fructus Lycii 23 25, the Radix Astragali 15 17, Poria 12 13, the Rhizoma Atractylodis Macrocephalae 9 10, Radix Angelicae Sinensis 15 17, Rhizoma Chuanxiong 15 17, Cortex Cinnamomi 67, Radix Glycyrrhizae Preparata 13 15, the Radix Paeoniae Alba 9 10, Radix Platycodoniss 13 15, Colla Corii Asini 15 17, ripe almond 21 23.A kind of temperature compensation QI and blood prescription half extractum film garment piece of the present invention, has the effect of temperature compensation QI and blood, and abnormal smells from the patient light it is easy to take, the features such as being difficult the moisture absorption and disintegrate.

Description

A kind of temperature compensation QI and blood prescription half extractum film garment piece and preparation method thereof
Technical field
The present invention relates to Chinese prescription technical field, more particularly, to a kind of temperature compensation QI and blood prescription half extractum film garment piece and its system Preparation Method.
Background technology
Chinese medicinal granule extracts concentration by single medicinal material and makes, and is clinically used for replacing decoction pieces to be deployed into decoction, its section Learn, flexibly, taking convenience the advantages of obtain more and more widely approving.Dry granulation has efficiency high, pelletization is not subject to Heat, finished product be the features such as be difficult the moisture absorption, be particularly suitable for Chinese medicinal granule directly pelletized using traditional Chinese medicinal extract powder, supplementary product consumption few Feature.Chinese medicinal granule adopts the direct dry granulation of extract powder, and one-shot forming rate generally reaches 50%, after secondary granulation, Major part becomes granule, and production efficiency is high, but, also some kind extract powder stickiness is poor, often once can not become Grain, needs repeatedly to extrude, low production efficiency, and the pellet hardness being obtained is big, and solution time is long.Traditional Chinese medicinal extract powder stickiness Greatly, hygroscopicity is strong is difficult to make granule it is difficult to molding, and the easy moisture absorption of granule made and being adhered, unstable, for improving tablet Quality, preferably plays its curative effect, plans it and changes system into Film coated tablets.?《The moulding process of Chinese medicine half extractum Film coated tablets is examined Examine》Middle Zhang Yuan etc. uses the granulating process of coronary disease plain film instead fluidized bed granulation method, and it is pelletized, tabletting and film coating procedure Carry out systematic study, the big production for Chinese medicine half extractum Film coated tablets provides test basis.Tabletting adds Pulvis Talci when always mixing, and can show Write the mobility improving granule, meet the technological requirement of tabletting.In granule, moisture is extruded when punch die is compressed to granule Surface to granule forms thin film, and the thin film of formation can play lubrication and improve the transmission of pressure thus increasing the hardness of tablet. The granule elasticity being completely dried is big, plasticity little it is difficult to be pressed into piece, the plasticity that the presence of amount of water can increase friability particle becomes Shape, reduces elasticity and strengthens tablet hardness.But the water content of granule is too high, both easily sticks punching in tableting processes, can affect simultaneously The mobility of granule.The solution of Chinese medical concrete and its preparation hygroscopic effect is to ensure that the stable key of the quality of the pharmaceutical preparations.Different product Plant composition different, hygroscopicity there is also larger difference, this requires that pharmacy worker studies in production practices and selects most preferably Production technology, control the relative humidity of workshop and preferable damp-prrof packing, such Chinese medical concrete and its preparation simultaneously Sucting wet problem can be readily solved surely.The probability mechanism of traditional Chinese medicinal extract powder moisture absorption includes:Existing in medicine can be with pole in hydrone Property light base form the polar group of hydrogen bond, activity especially therein is through base；Pass through between hydrone and Chinese medical concrete powder body to divide Sub- intermolecular forces attract each other, and Water Molecular Adsorption is in Chinese medical concrete powder surface；Acted on by capillary attraction, water adsorption and It is stored in the hole of powder body；Because in traditional Chinese medicinal extract powder, chemical substance is usually unformed shape, easily moisture absorption forms hydrate, It is changed into hydration crystal formation by anhydrous crystal forms after absorbing moisture.
It is reported that, the extract powder poor fluidity that east virus-clearing capsule extraction process is obtained, moisture absorption are big.Use microcrystalline cellulose In element, starch and prescription, Radix Scutellariae fine powder is adjuvant, mixes by different proportion with extract powder respectively, and wherein extract powder and starch are 1: 1 prescription largely improves hygroscopicity, its critical relative humidity be 60.5%, so it is desirable to workshop relatively wet Degree controls below 60%, controls workshop humidity to provide theoretical foundation for producing.At 40 DEG C, the condition of relative humidity 75% Under, made with the different auxiliary material Chinese medical concrete stronger to moisture absorption and study after electuary, by measuring Moisture percentage and facing Boundary's relative humidity, result shows：The electuary individually made as adjuvant with Lactose, once moisture absorption, can not maintain the granule of electuary Shape.Although the moisture absorption degree of Microcrystalline Cellulose is slightly larger than Lactose, easily pelletize, though granule deliquescing after moisture absorption, remain to maintenance Granular, therefore Microcrystalline Cellulose should be first-selected adjuvant for the extractum of moisture absorption.For improving the hygroscopicity of Radix Salviae Miltiorrhizae electuary, investigate respectively Single adjuvant (respectively soluble starch, sucrose, dextrin, Lactose）With two kinds of adjuvants (respectively Lactose and soluble starch, breast Sugar and sucrose, Lactose and dextrin, Lactose and carboxymethyl starch sodium, Lactose and Mannitol）On its hygroscopic impact.Result table Bright, the moisture absorption degree order of single adjuvant is Lactose, sucrose, soluble starch, dextrin, and Lactose is difficult moisture absorption most；Two kinds of adjuvants Moisture absorption degree order be Lactose and Mannitol, Lactose and sucrose, Lactose and soluble starch, Lactose and dextrin, Lactose and carboxylic Methyl starch sodium, Lactose and Mannitol are difficult moisture absorption most.Antiphlogistic capsule content starch and PVP, as adjuvant, not only can make Hydroscopicity reduces by 27.3%, and supplementary product consumption also complies with requirement.Ganyanning capsules are full extractum preparation, the easy moisture absorption.Prepare dry extract Afterwards, pulverize, add liquid paraffin, mix, investigate hydroscopicity in relative humidity 45% container.Result shows, liquid paraffin Consumption for 2% conveniently, adds liquid paraffin and has reached the effect reducing moisture absorption.The 40% ethanol extraction leaching with Herba Passiflorae Caeruleae When cream is spray-dried, add silica gel (Aerosil200）As desiccant adjuvant, there is certain anti-hygroscopic effect, And do not affect pharmaceutically active.
Content of the invention
The object of the invention is exactly the defect in order to make up prior art, provides a kind of temperature compensation QI and blood prescription half extractum film clothing Piece.
The present invention is achieved by the following technical solutions：
A kind of temperature compensation QI and blood prescription half extractum film garment piece, it is made up of following components and its weight portion：
Radix Rehmanniae Preparata 13-15, Fructus Lycii 23-25, Radix Astragali 15-17, Poria 12-13, Rhizoma Atractylodis Macrocephalae 9-10, Radix Angelicae Sinensis 15-17, Rhizoma Chuanxiong 15-17, Cortex Cinnamomi 6-7, Radix Glycyrrhizae Preparata 13-15, Radix Paeoniae Alba 9-10, Radix Platycodoniss 13-15, Colla Corii Asini 15-17, ripe almond 21-23.
A kind of described temperature compensation QI and blood prescription half extractum film garment piece, is made up of the following step：
1）, respectively the Radix Astragali, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Cinnamomi, Radix Glycyrrhizae Preparata, Radix Platycodoniss, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are cleaned up, mixing add 30-35 times amount water, soaks 30-35 minute, heated and boiled, turns slow fire infusion 1.5-2.5 hour, extracting solution is collected by filtration, injection Same water extracts again, merges extracting solution twice, and then heating concentrates；
2）, by Fructus Lycii, Radix Rehmanniae Preparata, Colla Corii Asini, ripe almond grinds, extract obtained with step 1 put in barrel, startup program, make Material is in fluidized state in barrel, sets and adjusts inlet temperature 85-90 DEG C, atomizing pressure 0.10-0.12MPa, temperature of charge 51-53 DEG C, compressor flow 120-140 M3•h- 1, feed flow revolution speed 15-20r min- 1, treat temperature of charge to 51-53 DEG C, start Spray bonding serosity, controls particle growth degree, till obtaining rounding uniform in size, being suitable for the granule that tabletting requires；
3）, by step 2 gained wet granular in hot air circulation drying oven, 25-30 minute be dried in 60-65 DEG C, discharging, cross 14- 20 mesh sieves, are cooled to room temperature；
4）, step 3 gains mixed add the micropowder silica gel of mass fraction 1.5-1.7%, 1.5-2% Radix et Rhizoma Nardostachyos volatile oil, 1.5- 1.7% Pulvis Talci mix homogeneously, adding 1.9-2.0 times amount 60-75% ethanol is wetting agent, in the environment of relative humidity 50-60% Under, regulation pressure is 0.45-0.50MPa, carries out tabletting, every tablet quality controls in 12.5-13g, prepared extractum piece；
5）, step 4 gained extractum piece carried out the HPMC film coating that concentration is 5-5.5%, subpackage, sealing preserve.
It is an advantage of the invention that：
A kind of temperature compensation QI and blood prescription half extractum film garment piece of the present invention, relative humidity controls below 62%, effectively to prevent granule Moisture absorption and lead to tabletting to stick punching, Film coated tablets moisture absorption, appearance the problems such as lead to clothing film deliquescing；In granule moisture punch die to The surface that grain is extruded to granule when being compressed forms thin film, the thin film of formation can rise lubrication improve the transmission of pressure from And increase the hardness of tablet.
The present invention is coated on dry granule table by process for modifying surface Pulvis Talci, micropowder silica gel and Radix et Rhizoma Nardostachyos volatile oil Face, thus reducing the hygroscopicity of Chinese medicine extract, improving the bad odor of Chinese medicine extract, improving the stability of traditional medicine volatile oil, Reduce irritation on mucous membrane of effective ingredient in Chinese etc..
A kind of temperature compensation QI and blood prescription half extractum film garment piece of the present invention, Fructus Lycii in side, flat property and sweet taste, return liver and kidney channel, grow Invigorating the liver and kidney, replenishing vital essence to improve eyesight；Colla Corii Asini, sweet, flat, return lung, liver and kidney channel, it is good at nourishing YIN and benefiting blood, the Radix Astragali, sweet, tepor, enter lung, spleen channel, Invigorating QI to consolidate the body surface resistance, diuresis torr sore, Radix Angelicae Sinensis, sweet, bitter, pungent, warm, enter the heart, liver, spleen channel, enrich blood, invigorate blood circulation, regulating menstruation, moisturize, laxation, river Rhizome of chuanxiong, pungent, temperature, Return liver, gallbladder, pericardium channel, blood-activating and qi-promoting, wind-expelling pain-stopping, four is ministerial drug, helps Fructus Lycii liver nourishing kidney yin, QI invigorating to support altogether The effect of blood.
Specific embodiment
A kind of temperature compensation QI and blood prescription half extractum film garment piece, it is made up of following components and its weight portion：
Radix Rehmanniae Preparata 13, Fructus Lycii 23, the Radix Astragali 15, Poria 12, the Rhizoma Atractylodis Macrocephalae 9, Radix Angelicae Sinensis 15, Rhizoma Chuanxiong 15, Cortex Cinnamomi 6, Radix Glycyrrhizae Preparata 13, the Radix Paeoniae Alba 9, Radix Platycodoniss 13rd, Colla Corii Asini 15, ripe almond 21.
A kind of described temperature compensation QI and blood prescription half extractum film garment piece, is made up of the following step：
1）, respectively the Radix Astragali, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Cinnamomi, Radix Glycyrrhizae Preparata, Radix Platycodoniss, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are cleaned up, mixing add 30 times amount water, soak 30 minutes, heated and boiled, turn slow fire infusion 1.5 hours, and extracting solution is collected by filtration, and inject same water again Extract, merge extracting solution twice, then heating concentrates；
2）, by Fructus Lycii, Radix Rehmanniae Preparata, Colla Corii Asini, ripe almond grinds, extract obtained with step 1 put in barrel, startup program, make Material is in fluidized state in barrel, sets and adjusts 85 DEG C of inlet temperature, atomizing pressure 0.10MPa, 51 DEG C of temperature of charge, blower fan Flow 120 M3•h- 1, feed flow revolution speed 15r min- 1, treat temperature of charge to 51 DEG C, start spray bonding serosity, control granule long Big degree, till obtaining rounding uniform in size, being suitable for the granule that tabletting requires；
3）, by step 2 gained wet granular in hot air circulation drying oven, in 60 DEG C of dryings 25 minutes, discharging, cross 14 mesh sieves, cold But to room temperature；
4）, step 3 gains mixed add the micropowder silica gel of mass fraction 1.5%, 1.5% Radix et Rhizoma Nardostachyos volatile oil, 1.5% Pulvis Talci Mix homogeneously, adding 1.9 times amount 60% ethanol is wetting agent, and in the environment of relative humidity 50%, adjusting pressure is 0.45MPa, carries out tabletting, and every tablet quality controls in 12.5g, prepared extractum piece；
5）, step 4 gained extractum piece is carried out the HPMC film coating that concentration is 5%, subpackage, sealing preserve.

Claims (2)

1. a kind of temperature compensation QI and blood prescription half extractum film garment piece is it is characterised in that it is made up of following components and its weight portion：
Radix Rehmanniae Preparata 13-15, Fructus Lycii 23-25, Radix Astragali 15-17, Poria 12-13, Rhizoma Atractylodis Macrocephalae 9-10, Radix Angelicae Sinensis 15-17, Rhizoma Chuanxiong 15-17, Cortex Cinnamomi 6-7, Radix Glycyrrhizae Preparata 13-15, Radix Paeoniae Alba 9-10, Radix Platycodoniss 13-15, Colla Corii Asini 15-17, ripe almond 21-23.
2. a kind of temperature compensation QI and blood prescription half extractum film garment piece according to claim 1 is it is characterised in that be by the following step Make：
1）, respectively the Radix Astragali, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Cortex Cinnamomi, Radix Glycyrrhizae Preparata, Radix Platycodoniss, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are cleaned up, mixing add 30-35 times amount water, soaks 30-35 minute, heated and boiled, turns slow fire infusion 1.5-2.5 hour, extracting solution is collected by filtration, injection Same water extracts again, merges extracting solution twice, and then heating concentrates；
2）, by Fructus Lycii, Radix Rehmanniae Preparata, Colla Corii Asini, ripe almond grinds, extract obtained with step 1 put in barrel, startup program, make Material is in fluidized state in barrel, sets and adjusts inlet temperature 85-90 DEG C, atomizing pressure 0.10-0.12MPa, temperature of charge 51-53 DEG C, compressor flow 120-140 M3•h- 1, feed flow revolution speed 15-20r min- 1, treat temperature of charge to 51-53 DEG C, start Spray bonding serosity, controls particle growth degree, till obtaining rounding uniform in size, being suitable for the granule that tabletting requires；
3）, by step 2 gained wet granular in hot air circulation drying oven, 25-30 minute be dried in 60-65 DEG C, discharging, cross 14- 20 mesh sieves, are cooled to room temperature；
4）, step 3 gains mixed add the micropowder silica gel of mass fraction 1.5-1.7%, 1.5-2% Radix et Rhizoma Nardostachyos volatile oil, 1.5- 1.7% Pulvis Talci mix homogeneously, adding 1.9-2.0 times amount 60-75% ethanol is wetting agent, in the environment of relative humidity 50-60% Under, regulation pressure is 0.45-0.50MPa, carries out tabletting, every tablet quality controls in 12.5-13g, prepared extractum piece；
5）, step 4 gained extractum piece carried out the HPMC film coating that concentration is 5-5.5%, subpackage, sealing preserve.
CN201610897093.1A 2016-10-14 2016-10-14 A kind of temperature compensation QI and blood prescription half extractum film garment piece and preparation method thereof Pending CN106474266A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108294311A (en) * 2018-03-09 2018-07-20 徐永新 A kind of warm the womb cream of nourishing face and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108294311A (en) * 2018-03-09 2018-07-20 徐永新 A kind of warm the womb cream of nourishing face and preparation method thereof

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Application publication date: 20170308