CN104524273A - Preparation method of Yinqiao preparation - Google Patents
Preparation method of Yinqiao preparation Download PDFInfo
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Abstract
The invention provides a preparation method of a Yinqiao preparation. The Yinqiao preparation is prepared from honeysuckle, fructus forsythia, mint, schizonepeta, fermented soybean, fried burdock, platycodon grandiflorum, lophatherum gracile, liquorice and auxiliary materials. The preparation method can be used for improving the extraction rate of the forsythin in the fructus forsythia so as to improve the drug therapeutic effect.
Description
Technical field
The present invention relates to a kind of preparation method of YINQIAO preparation, belong to the technical field of Chinese medicine.
Background technology
As everyone knows, wind heat diseases caused by exogenous pathogenic factor, are multiplely born in spring and summer.Spring is windy, and weather turns temperature, therefore wind and heterogeneous the holding concurrently of warm heresy are caused a disease; Summer, outdoor was sultry, and indoor are comparatively nice and cool again, the indoor and outdoor fluctuation of temperature, also easily ill.Anemopyretic cold system wind heat is controlled evil invasion and attack lung and is defended, and evil criminal's table of wind heat, lung qi are become estranged, and cause and defend table discord, impairment of purifying function of the lung and the disease that occurs.After people have suffered from anemopyretic cold, just there will be nasal obstruction, cough, heating weight, micro evil wind, distending pain in the head, have that antiperspirant, red swelling and pain of throat, expectorant are glutinous or yellow, the symptom such as yellow thick nasal discharge of having a stuffy nose, thirst and liking drink, the tip of the tongue limit are red, the micro-Huang of white and thin fur.The traditional Chinese medical science is thought, anemopyretic cold is the exterior syndrome caused by heresy experiencing wind heat, and general symptom has sore throat, usually just pain before cold symptoms, and expectorant is yellow or band black usually; Flow dense tears, usually yellow; Tongue fur band point is yellow, and be also likely white, tongue body is usually redder; Constipation; Fever of the body, thirsty, vexed; Vein is generally rapid pulse or full pulse, be exactly pulse ratio is normally fast.Infantile anemopyretic cold main manifestations for fever heavy, but aversion to wind of being afraid of cold is not obvious, the turbid tears of nasal blockage stream, coughs low voice speaking, or has sticky yellow sputum, and headache, thirst and liking drink, pharynx are red, dry pharynx or sufferings.Large dry stool, yellow urine, checks that visible tonsil is red and swollen, pharyngeal congestion, tongue fur BOHUANG or yellow thick, red tongue, floating pulse and fast.
YINQIAO sheet is the conventional Chinese patent medicine for the treatment of flu, is made up of Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, Semen Sojae Preparatum, Fructus Arctii (parched), Radix Platycodonis, Herba Lophatheri and licorice medicinal materials.The pungent table that cools completely of its function, heat-clearing and toxic substances removing, for anemopyretic cold, fever and headache, cough, xerostomia, the disease such as to have sore throat, this product is particularly conventional.
YINQIAO JIEDU PIAN is prepared from by Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, Semen Sojae Preparatum, Fructus Arctii (parched), Radix Platycodonis, Herba Lophatheri and Radix Glycyrrhizae and adjuvant.There are relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, effect of heat-clearing and toxic substances removing.For anemopyretic cold, fever and headache, cough, xerostomia, has sore throat.The method of existing production YINQIAO JIEDU PIAN is generally adopt the method that drug standard is recorded, and is that Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieves; Herba Menthae and Herba Schizonepetae adopt vapor distillation to extract volatile oil, and the another device of the aqueous solution after distillation is collected; Medicinal residues and Fructus Forsythiae, Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae decoct with water extraction; After Semen Sojae Preparatum adds water boil, warm macerating, merge above each medicinal liquid, be condensed into thick paste, add Flos Lonicerae, Radix Platycodonis fine powder and adjuvant, spray adds Herba Menthae, Herba Schizonepetae volatile oil makes traditional drug formulations.But applicant studies discovery, the medicinal residues and Fructus Forsythiae, Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae mixed extraction that extract the Herba Menthae after volatile oil and Herba Schizonepetae can be affected the extraction ratio of Phillyrin in Forsythia suspensa, therefore a kind of preparation method of new YINQIAO preparation has great importance.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of YINQIAO preparation.The method of the invention can improve the extraction ratio of Phillyrin in Forsythia suspensa, thus can improve curative effect of medication.
For solving above technical problem, the present invention realizes by the following technical solutions:
A kind of preparation method of YINQIAO preparation, calculate according to composition by weight, described YINQIAO preparation is prepared from primarily of Flos Lonicerae 100-300 part, Fructus Forsythiae 150-250 part, Herba Menthae 80-140 part, Herba Schizonepetae 50-130 part, Semen Sojae Preparatum 50-150 part, Fructus Arctii (parched) 100-140 part, Radix Platycodonis 80-140 part, Herba Lophatheri 60-100 part and Radix Glycyrrhizae 80-120 part and adjuvant; The preparation method of described YINQIAO preparation is: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae decoct with water 1-3 bis-times, each 1-3 hour, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating 1-3 time, each 1-3 hour, merges leachate, filters; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae decocts with water 1-3 time, each 1-3 hour, collecting decoction, and filter, reconcentration becomes thick paste; Above-mentioned thick paste, Flos Lonicerae, Radix Platycodonis fine powder mix with conventional pharmaceutical adjuvants, and spray adds Herba Menthae, Herba Schizonepetae volatile oil, more conventionally makes different pharmaceutical preparation.
Specifically, aforesaid YINQIAO preparation, calculate according to composition by weight, be prepared from primarily of Flos Lonicerae 200 parts, Fructus Forsythiae 200 parts, Herba Menthae 120 parts, Herba Schizonepetae 80 parts, Semen Sojae Preparatum 100 parts, Fructus Arctii (parched) 120 parts, Radix Platycodonis 120 parts, Herba Lophatheri 80 parts and 100 parts, Radix Glycyrrhizae and adjuvant.
The preparation method of aforesaid YINQIAO preparation, is prepared according to following step: the preparation method of described YINQIAO preparation is: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Above-mentioned thick paste, Flos Lonicerae, Radix Platycodonis fine powder mix with conventional pharmaceutical adjuvants, and spray adds Herba Menthae, Herba Schizonepetae volatile oil, more conventionally makes different pharmaceutical preparation.
Described pharmaceutical preparation is tablet, granule, soft extract, capsule, pill, oral liquid, powder, sublimed preparation or suspensoid.
The preparation method of described tablet is: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add the starch of Flos Lonicerae and Radix Platycodonis fine powder and the amount of making 10%, mixing, makes granule, dry, lets cool, and spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, tabletted, to obtain final product.
The preparation method of described granule is: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add the cane sugar powder of Flos Lonicerae and Radix Platycodonis fine powder and the amount of making 20%, spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, makes granule, dry, to obtain final product.
Described soft extract is prepared like this: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add Flos Lonicerae and Radix Platycodonis fine powder, spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, to obtain final product.
Described capsule is prepared like this: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add the dextrin of Flos Lonicerae and Radix Platycodonis fine powder and the amount of making 10%, spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, at 60 DEG C, dry, pulverize into fine powder under 0.07Mpa ~ 0.08Mpa condition, loads capsule, to obtain final product.
Medicine of the present invention is prepared from by Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, Semen Sojae Preparatum, Fructus Arctii (parched), Radix Platycodonis, Herba Lophatheri and Radix Glycyrrhizae and adjuvant.Wherein, Flos Lonicerae has another name called the flower of Radix Ophiopogonis (formal name used at school: Lonicera japonica) for opening at the beginning of Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or band, property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil, can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, send out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain.Fructus Forsythiae Latin literary fame: Forsythia suspensa (Thunb.) Vahl is the fruit of Oleaceae, the drying of Forsythia machaka, bitter, cool, enter the heart, liver, gallbladder meridian, heat clearing away, removing toxic substances, eliminating stagnation, detumescence.Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Herba Menthae is labiate, namely belongs to other dry herbs together, acrid in the mouth, cool in nature, enter lung, Liver Channel, dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting, for affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest.Herba Schizonepetae (Nepeta cataria L.) is Labiatae, the stem and leaf of Nepeta perennial plant drying and spica, flat, temperature, and nontoxic, faint scent is dense, and Herba Schizonepetae is diaphoresis, antipyretic, town expectorant, dispel the wind, removing heat from blood, for controlling influenza, the diaphoresis of headache cold and heat, vomiting.Semen Sojae Preparatum is the fermentation processing product of the mature seed of legume soybean, and its nature and flavor bitter cold, has and induce sweat, relieving restlessness, Xuan Yu, effect of removing toxic substances, for typhoid fever calentura, and cold and heat, headache, irritated, uncomfortable in chest.Fructus Arctii (parched) is a kind of concocting method of the dry mature fruit of Compositae biennial herb plant Fructus Arctii, cold in nature, acrid in the mouth, hardship, for rash of detoxifying, and sore-throat relieving eliminating stagnation, preventing phlegm from forming and stopping coughing.For measles without adequate eruption, laryngopharynx swelling and pain, wind heat cough with asthma.Radix Platycodonis Latin literary fame: Platycodon grandiflorus (Jacq.) A. DC. is the root of campanulaceae, Platycodon grandiflouorum plant drying, and lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.Herba Lophatheri Classification system: Lophatherum gracile) be grass family, Herba Lophatheri belongs to the root of herbaceos perennial drying, has refrigerant, antipyretic, diuresis and the effect of hastening parturition; For disease heat, cough with dyspnea, haematemesis, pyretic toxicity wind in the heart, only quench one's thirst, press borax poison, expectorant, control fanatical unhappiness, apoplectic aphasia in silence, pain wind syndrome of head, spasmolytic are throbbed with fear, pestilence fan is vexed, kill small worm, heat extraction delays spleen.Radix Glycyrrhizae is the root of pulse family, the drying of Glycyrrhiza perennial herb, feeble QI, and taste is sweet and special, and function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen.
We are with Flos Lonicerae, Fructus Forsythiae for monarch drug, and heat-clearing and toxic substances removing, gently declares expelling pathogenic factors from the exterior.Herba Menthae, Semen Sojae Preparatum, Herba Lophatheri, Herba Schizonepetae, Fructus Arctii are ministerial drug, with the pungent table that cools completely, disperse the heresy of wind heat, and Fructus Arctii etc. are double can resolving toxin and disinhibiting the throat.The pungent flat liter of compatibility Radix Platycodonis floats, and goes on and reaches table, and draw floating a surname of all medicines liter and fall apart with pathogenic factor in the exterior of dispelling, lung qi dispersing eliminates the phlegm, sore-throat relieving eliminating stagnation.Radix Glycyrrhizae is coordinating the actions of various ingredients in a prescription then.In side, all medicines are worked in coordination, and play the merit of pungent cool completely table and heat-clearing and toxic substances removing altogether.
In the preparation method of existing YINQIAO JIEDU PIAN, be that Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve; Herba Menthae and Herba Schizonepetae adopt vapor distillation to extract volatile oil, and the another device of the aqueous solution after distillation is collected; Medicinal residues and Fructus Forsythiae, Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae decoct with water extraction; After Semen Sojae Preparatum adds water boil, warm macerating, merge above each medicinal liquid, be condensed into thick paste, add Flos Lonicerae, Radix Platycodonis fine powder and adjuvant, spray adds Herba Menthae, Herba Schizonepetae volatile oil.But applicant studies discovery, the medicinal residues and Fructus Forsythiae, Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae mixed extraction that extract the Herba Menthae after volatile oil and Herba Schizonepetae can be affected the extraction ratio of Phillyrin in Forsythia suspensa, Fructus Forsythiae is decocted with water extraction separately, and in the medicine made, the extraction ratio of phillyrin adds much unexpectedly.May be because the extraction ratio of certain composition influence phillyrin of Herba Menthae, Herba Schizonepetae, Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae causes.
Invention has been a large amount of experimentatioies, is below the result of experimentation of the present invention:
Experimental example 1: the extraction ratio of phillyrin is investigated
One, raw material
1, YINQIAO JIEDU PIAN of the present invention, is prepared by the method for embodiment 1.
2, existing YINQIAO JIEDU PIAN, is prepared by standard technology, as follows:
Prescription: Flos Lonicerae 200g, Fructus Forsythiae 200g, Herba Menthae 120g, Herba Schizonepetae 80g, Semen Sojae Preparatum 100g, Fructus Arctii (parched) 120g, Radix Platycodonis 120g, Herba Lophatheri 80g, Radix Glycyrrhizae 100g.
Technique: take Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, Semen Sojae Preparatum, Fructus Arctii (parched), Radix Platycodonis, Herba Lophatheri and Radix Glycyrrhizae in proportion, Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve; Herba Menthae and Herba Schizonepetae adopt vapor distillation to extract volatile oil, and the another device of the aqueous solution after distillation is collected; Medicinal residues and Fructus Arctii, Fructus Forsythiae, Herba Lophatheri, Radix Glycyrrhizae add the soak by water 2 times of 10 times amount, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating 2 times, each 2 hours, merge leachate, filter; Merge above each medicinal liquid, be concentrated into thick paste, add the adjuvant of the routine dose of Flos Lonicerae and Radix Platycodonis fine powder and tablet, mixing, makes granule, dry, lets cool, and spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, be pressed into 1000, every sheet 0.5g, to obtain final product.
Two, experimental technique and result
1, experimental technique:
The content assaying method of phillyrin: according to high-performance liquid chromatogram determination.
Chromatographic condition and system suitability: Agilent1200 full automatic high efficiency chromatograph of liquid (diode array detector, quaternary pump, column oven, temperature automatically controlled injector).Diamonsil
tMc18 chromatographic column (250mm × 4.6mm, 5 μm), mobile phase: acetonitrile (A)-0.1% phosphate aqueous solution (B), flow velocity 1.0mL/min, column temperature 30 DEG C, determined wavelength is 228 nm, sample size 40 μ L, gradient elution program is:
Number of theoretical plate calculates should be not less than 5000 by phillyrin peak.
The preparation of reference substance solution: precision takes phillyrin reference substance 4.94mg, puts in 10mL measuring bottle, is diluted to scale, shakes up, be mixed with the phillyrin reference substance storing solution that mass concentration is 0.494mg/mL with dissolve with methanol; Precision pipettes phillyrin reference substance storing solution 1.2mL, puts in 10mL measuring bottle, with methanol dilution to scale, shakes up, and is mixed with the phillyrin reference substance solution of mass concentration 0.05928mg/mL.
The preparation of need testing solution: get test sample YINQIAO JIEDU PIAN 10, accurately weighed, porphyrize, precision takes the medicated powder of about 1, put in 100mL tool plug conical flask, precision adds 50% methanol 50mL, its quality accurately weighed, flood supersound extraction 30 min after 1 h, after room temperature places 30 min, supply the quality of less loss with 50% methanol, shake up, filter, get subsequent filtrate in right amount through first
Namely need testing solution is obtained after alcohol dilution.The compound method of existing YINQIAO JIEDU PIAN need testing solution with the preparation of YINQIAO JIEDU PIAN need testing solution of the present invention, all parallel preparation of each sample 6 parts.
Algoscopy: accurate absorption reference substance solution and each 40 μ l of need testing solution respectively, injection liquid chromatography, measures, to obtain final product.
2, experimental result: in the meansigma methods of 6 parts, in existing YINQIAO JIEDU PIAN, the content of phillyrin is 0.67mg/ sheet; In YINQIAO JIEDU PIAN of the present invention, the content of phillyrin is 1.12mg/ sheet.
Conclusion: in Tablets, the content of phillyrin is higher.In like manner, the medicine of other dosage forms made according to extracting method of the present invention, the extraction ratio of phillyrin also should increase.
Compared with prior art, medicine prepared by the method for the invention, the extraction ratio of Phillyrin in Forsythia suspensa is higher, reaches goal of the invention.
detailed description of the invention:
Embodiment 1:
Prescription: Flos Lonicerae 200g, Fructus Forsythiae 200g, Herba Menthae 120g, Herba Schizonepetae 80g, Semen Sojae Preparatum 100g, Fructus Arctii (parched) 120g, Radix Platycodonis 120g, Herba Lophatheri 80g, Radix Glycyrrhizae 100g.
Technique: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add the starch of Flos Lonicerae and Radix Platycodonis fine powder and the amount of making 10%, mixing, makes granule, dry, lets cool, and spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, tabletted, every sheet 0.5g, obtains tablet.
Usage and dosage: oral, one time 4,2-3 time on the one.
Embodiment 2:
Prescription: Flos Lonicerae 200g, Fructus Forsythiae 200g, Herba Menthae 120g, Herba Schizonepetae 80g, Semen Sojae Preparatum 100g, Fructus Arctii (parched) 120g, Radix Platycodonis 120g, Herba Lophatheri 80g, Radix Glycyrrhizae 100g.
Technique: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add the cane sugar powder of Flos Lonicerae and Radix Platycodonis fine powder and the amount of making 20%, spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, makes granule, dry, obtains granule.
Usage and dosage: oral, a 15g, 3 times on the one.
Embodiment 3:
Prescription: Flos Lonicerae 200g, Fructus Forsythiae 200g, Herba Menthae 120g, Herba Schizonepetae 80g, Semen Sojae Preparatum 100g, Fructus Arctii (parched) 120g, Radix Platycodonis 120g, Herba Lophatheri 80g, Radix Glycyrrhizae 100g.
Technique: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add Flos Lonicerae and Radix Platycodonis fine powder, spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, obtains soft extract.
Oral, a 15g, 3 times on the one.
Embodiment 4:
Prescription: Flos Lonicerae 200g, Fructus Forsythiae 200g, Herba Menthae 120g, Herba Schizonepetae 80g, Semen Sojae Preparatum 100g, Fructus Arctii (parched) 120g, Radix Platycodonis 120g, Herba Lophatheri 80g, Radix Glycyrrhizae 100g.
Technique: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add the dextrin of Flos Lonicerae and Radix Platycodonis fine powder and the amount of making 10%, spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, at 60 DEG C, dry, pulverize into fine powder under 0.07Mpa ~ 0.08Mpa condition, loads capsule, obtains capsule.
Oral, one time 3,3 times on the one.
Claims (8)
1. the preparation method of a YINQIAO preparation, it is characterized in that: calculate according to composition by weight, described YINQIAO preparation is prepared from primarily of Flos Lonicerae 100-300 part, Fructus Forsythiae 150-250 part, Herba Menthae 80-140 part, Herba Schizonepetae 50-130 part, Semen Sojae Preparatum 50-150 part, Fructus Arctii (parched) 100-140 part, Radix Platycodonis 80-140 part, Herba Lophatheri 60-100 part and Radix Glycyrrhizae 80-120 part and adjuvant; The preparation method of described YINQIAO preparation is: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae decoct with water 1-3 bis-times, each 1-3 hour, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating 1-3 time, each 1-3 hour, merges leachate, filters; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae decocts with water 1-3 time, each 1-3 hour, collecting decoction, and filter, reconcentration becomes thick paste; Above-mentioned thick paste, Flos Lonicerae, Radix Platycodonis fine powder mix with conventional pharmaceutical adjuvants, and spray adds Herba Menthae, Herba Schizonepetae volatile oil, more conventionally makes different pharmaceutical preparation.
2. the preparation method of YINQIAO preparation as claimed in claim 1, it is characterized in that: calculate according to composition by weight, described YINQIAO preparation is prepared from primarily of Flos Lonicerae 200 parts, Fructus Forsythiae 200 parts, Herba Menthae 120 parts, Herba Schizonepetae 80 parts, Semen Sojae Preparatum 100 parts, Fructus Arctii (parched) 120 parts, Radix Platycodonis 120 parts, Herba Lophatheri 80 parts and 100 parts, Radix Glycyrrhizae and adjuvant.
3. the preparation method of YINQIAO preparation as claimed in claim 1, is characterized in that: be prepared according to following step: the preparation method of described YINQIAO preparation is: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Above-mentioned thick paste, Flos Lonicerae, Radix Platycodonis fine powder mix with conventional pharmaceutical adjuvants, and spray adds Herba Menthae, Herba Schizonepetae volatile oil, more conventionally makes different pharmaceutical preparation.
4. the preparation method of YINQIAO preparation as described in claim 3 or 4, is characterized in that: described pharmaceutical preparation is tablet, granule, soft extract, capsule, pill, oral liquid, powder, sublimed preparation or suspensoid.
5. the preparation method of YINQIAO preparation as claimed in claim 4, is characterized in that: the preparation method of described tablet is: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add the starch of Flos Lonicerae and Radix Platycodonis fine powder and the amount of making 10%, mixing, makes granule, dry, lets cool, and spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, tabletted, to obtain final product.
6. the preparation method of YINQIAO preparation as claimed in claim 4, is characterized in that: the preparation method of described granule is: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add the cane sugar powder of Flos Lonicerae and Radix Platycodonis fine powder and the amount of making 20%, spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, makes granule, dry, to obtain final product.
7. the preparation method of YINQIAO preparation as claimed in claim 4, is characterized in that: described soft extract is prepared like this: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add Flos Lonicerae and Radix Platycodonis fine powder, spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, to obtain final product.
8. the preparation method of YINQIAO preparation as claimed in claim 4, is characterized in that: described capsule is prepared like this: Flos Lonicerae, Radix Platycodonis are ground into fine powder respectively, sieve for subsequent use; Herba Menthae, Herba Schizonepetae vapor distillation extract volatile oil, and the another device of the aqueous solution after distillation is collected, for subsequent use; Medicinal residues and Fructus Arctii, Herba Lophatheri, Radix Glycyrrhizae add 10 times amount soak by water secondaries, each 2 hours, collecting decoction, filter; After Semen Sojae Preparatum adds water boil, in 80 DEG C of warm macerating secondaries, each 2 hours, merge leachate, filter; Merge above-mentioned medicinal liquid, be condensed into thick paste; Fructus Forsythiae adds 10 times amount soak by water secondaries, each 2 hours, collecting decoction, and filter, reconcentration becomes thick paste; Add the dextrin of Flos Lonicerae and Radix Platycodonis fine powder and the amount of making 10%, spray adds Herba Menthae, Herba Schizonepetae volatile oil, and mixing, at 60 DEG C, dry, pulverize into fine powder under 0.07Mpa ~ 0.08Mpa condition, loads capsule, to obtain final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079564A (en) * | 2015-09-16 | 2015-11-25 | 韩志强 | Preparation method of fructus forsythiae antidotal tablet |
| CN109820094A (en) * | 2019-02-27 | 2019-05-31 | 盐城工业职业技术学院 | It is a kind of for preventing and treating the feed and preparation method thereof of channel catfish virosis |
| CN114452356A (en) * | 2020-11-09 | 2022-05-10 | 河北百善药业有限公司 | Lonicera and Forsythia detoxifying tablet and preparation method thereof |
-
2014
- 2014-12-18 CN CN201410786635.9A patent/CN104524273A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079564A (en) * | 2015-09-16 | 2015-11-25 | 韩志强 | Preparation method of fructus forsythiae antidotal tablet |
| CN109820094A (en) * | 2019-02-27 | 2019-05-31 | 盐城工业职业技术学院 | It is a kind of for preventing and treating the feed and preparation method thereof of channel catfish virosis |
| CN114452356A (en) * | 2020-11-09 | 2022-05-10 | 河北百善药业有限公司 | Lonicera and Forsythia detoxifying tablet and preparation method thereof |
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Application publication date: 20150422 |