CN102949526A - Healthcare particles for treating chronic pharyngitis and preparation method thereof - Google Patents

Abstract

The invention discloses healthcare particles for treating chronic pharyngitis and a preparation method thereof. The healthcare particles comprise the following raw material medicament components in parts by weight: 10 parts of grosvener siraitia, 30 parts of radix pseudostellariae, 15 parts of codonopsis pilosula, 10 parts of boat-fruited scaphium seed, 6 parts of Indian trum etflower seed, 10 parts of tangerine peel, 6 parts of dark plum fruit, 6 parts of licorice, 10 parts of olive, 10 parts of passion flower stem, 20 parts of towel gourd stem, 30 parts of astragalus mongholicus, 12 parts of horsetail, 10 parts of lonicera japonica, 8 parts of lotus base, 6 parts of trollius chinensis, 12 parts of tribulus terrestris plant, 10 parts of biond magnolia flower and 10 parts of longjing tea. The particles are prepared according to herbal prescription compatible regulation, have the efficacies of tonifying qi and yin and relieving sore throat and pains, and mainly treat diseases, such as chronic sore throat.

Description

Treatment chronic pharyngitis health product granule and preparation method thereof

Technical field

The invention belongs to the health care medicine technical field, particularly about treatment chronic pharyngitis health product granule and preparation method thereof.

Background technology

Chronic pharyngitis is for reaching adenoid chronic inflammatory disease under pharynx mucosa, the mucosa.The diffusivity pharyngeal inflammation often is the part of upper respiratory tract chronic inflammatory disease; The limitation pharyngeal inflammation then mostly is pharynx lymphoid tissue inflammation.The disease that the present invention relates to is characterized in that in clinical common, and the course of disease is long, and symptom is repeatedly outbreak easily.Be more common in the adult, the child also can occur.General Symptoms is all not obvious, take local symptom as main.Various chronic pharyngitis symptom is roughly similar and varied, as pharyngeal sense of discomfort, foreign body sensation, pharyngeal secretions be difficult for bringing up, pharyngeal gargalesthesia, burn feeling, dry sensation or excitement, also the hypodynia sense can be arranged.Because the pharynx rear wall adheres to because pharyngeal chronic inflammatory disease causes than thick secretions usually, and because nose, nasal sinuses, nasopharynx pathological changes cause the mouth breathing at night, the morning time-out of being everlasting irritable cough occurs and feels sick.Because the foreign body in pharynx sense can show as frequently and swallow.Pharyngeal secretions is few and be difficult for expectoration person and often show as habitually dry cough and the action of coughing up phlegm of clearing one's throat, and can cause pharyngeal mucosa hemorrhage if firmly cough or clear one's throat, and causes and is with blood in the secretions.As seen the chronic simple pharyngitis inspection swallows the mucosa chronic congestion, and little varix is kermesinus, and there is a small amount of thick secretions on the surface.As seen the pharyngeal inspection of chronic hypertrophic pharyngitis swallows a plurality of graininess folliculus protuberances of rear wall, be the chronic congestion shape, sometimes combine together, can form the cryptomere white point at the top of lymph granule protuberance, visible yellow-white exudate during ulceration, the lateral pharyngeal band lymphoid tissue can thicken and be streak.Chronic atrophic pharyngitis or chronic pharyngitis sicca are pharyngeal with dry crusts, with halitosis.Inspection sees that the pharynx mucosa is dry, poor, and severe one is squamous, shinny.Can cover the purulence dry crusts, pathological changes is extended to pharyngotympanic tube can cause tinnitus, auditory dysesthesia.Spread to throat, can cause hoarseness.The pharyngeal training of anti-fluidity pharyngolaryngitis is had a medical check-up with chronic simple and hyperplastic pharyngitis, and Laryngopharyngeal reflux may be with vocal nodule, polyp of vocal cord and hoarseness occurred.Above-mentioned symptom be everlasting with throat excessively, abrupt change of climate, ambient temperature and humidity increases the weight of when changing, especially take atrophic and pharyngitis sicca as outstanding.。Although obtained some experiences with the Chinese medicine chronic pharyngitis, also existed the problem that cure rate is low and the course for the treatment of is long at present.Mechanism research is carried out not yet well, and pharmacological research is heavy single medicinal material mainly, and is then less to the research of compound recipe.The present invention carries out comprehensively deep research from these several respects, further improves cure rate, Shorten the Treatment Process.

Summary of the invention

Purpose of the present invention aims to provide treatment chronic pharyngitis health product granule and preparation method thereof, has supplementing QI and nourishing YIN, and the effect of relieving sore throat and pain cures mainly the diseases such as chronic pharyngolaryngitis.Its taking dose is little, mouthfeel good, taking convenience, absorption is very fast, bioavailability is high, steady quality, production technology are simple.

Technical scheme of the present invention is: design treatment chronic pharyngitis health product granule and preparation method thereof is characterized in that crude drug composition and weight proportion thereof that it contains are: 10 parts of Fructus Momordicaes, 30 parts of Radix Pseudostellariaes, 15 parts of Radix Codonopsis, 10 parts of Semen Sterculiae Lychnophoraes, 6 parts of Semen Oroxylis, 10 parts of Pericarpium Citri Reticulataes, 6 parts of Fructus Mumes, 6 parts in Radix Glycyrrhizae, 10 parts of Fructus Canarii albis, 10 parts on Herba Passiflorae Caeruleae stem, 20 parts of Ramulus Luffaes, 30 parts of the Radixs Astragali, 12 parts of Herba Equiseties Hiemalis, 10 parts of Flos Loniceraes, 8 parts of the lotus bases of a fruit, 6 parts of Flos Trolliis, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Flos Magnoliaes, 10 parts of dragon well green teas.

It may further comprise the steps described a kind of preparation method that is used for the treatment of chronic pharyngitis health product granule:

1) by following weight ratio weighting raw materials: 10 parts of Fructus Momordicaes, 30 parts of Radix Pseudostellariaes, 15 parts of Radix Codonopsis, 10 parts of Semen Sterculiae Lychnophoraes, 6 parts of Semen Oroxylis, 10 parts of Pericarpium Citri Reticulataes, 6 parts of Fructus Mumes, 6 parts in Radix Glycyrrhizae, 10 parts of Fructus Canarii albis, 10 parts on Herba Passiflorae Caeruleae stem, 20 parts of Ramulus Luffaes, 30 parts of the Radixs Astragali, 12 parts of Herba Equiseties Hiemalis, 10 parts of Flos Loniceraes, 8 parts of the lotus bases of a fruit, 6 parts of Flos Trolliis, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Flos Magnoliaes, 10 parts of dragon well green teas.

2) above 19 flavor medicines decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, gradation filtered, and merging filtrate dusts with spray dryer, and is for subsequent use;

3) dry powder described in the step 2 is added starch, anhydrous glucose, stevioside, mix homogeneously;

4) said mixture is added 80% ethanol soft material processed;

5) granulate arrangement with soft material 14 mesh sieves.

6) packing, warehouse-in get final product.

Advantage of the present invention is: in conjunction with the theoretical prescription of modern Chinese medicine, have supplementing QI and nourishing YIN according to traditional Chinese medical science tradition prescription method, the effect of relieving sore throat and pain cures mainly the diseases such as chronic pharyngolaryngitis.The wherein antiinflammatory that wets one's whistle of the Fructus Momordicae in the prescription, the heat clearing away YIN nourishing.Be applicable to acute/chronic pharyngitis and have the diseases such as the pharyngalgia of asthenic fire, hoarseness, expectoration are not well, bottleneck throat foreign body sensation.Radix Pseudostellariae is mended strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Control the cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, edema is quenched one's thirst, and spirit is tired.Radix Codonopsis has invigorating the spleen and replenishing QI, the effect of spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst etc." Bencao Congxin " record: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.A little less than the middle feeble QI, mend in order to transfer, very smooth and proper.”。The Semen Sterculiae Lychnophorae clearing heat and moistening lung, resolving toxin and disinhibiting the throat.Be applicable to the diseases such as pharyngalgia, dry cough without phlegm, hoarseness.Semen Oroxyli pharyngalgia sore throat; Hoarseness; Cough; Stomachache due to hyperactive liver-QI attacking the stomach; Skin infection is burst for a long time and is not held back; Acute eczema.Pericarpium Citri Reticulatae is used for that insufficiency of the spleen diet reduces, dyspepsia, and the disease such as nausea and vomiting.This product dampness and can spleen benefiting and stimulating the appetite is applicable to the diseases such as weakness of the spleen and stomach, diet minimizing, dyspepsia, loose stool and diarrhea, the fit applications such as normal and Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria.Can spleen invigorating because of it, can regulate the flow of vital energy again, so often make as the assistant of Qi-tonifying drug, can make tonify without causing stagnation, prevent from stopping up the swollen effect of doing of holding back.Fructus Mume is astringed the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.Be used for chronic cough of deficiency lung; The deficiency-heat excessive thirst; Chronic malaria; Chronic diarrhea; Dysentery; Have blood in stool; Hematuria; Metrorrhagia; Ascariasis of biliary tract stomachache; Vomiting; Ancylostomiasis.Radix Glycyrrhizae has the effect of coordinating the actions of various ingredients in a prescription.The merit that Fructus Canarii albi has lung-heat clearing and detoxification to reduce phlegm is used for preventing and treating the upper respiratory infectious disease, soothes sore throat.The Herba Passiflorae Caeruleae stem helps digest, preventing phlegm from forming and stopping coughing, control deficiency of the kidney and nourishing and fit keeping function, anti-inflammatory analgetic, invigorate blood circulation keep fit, enriching yin and nourishing kidney.Ramulus Luffae can make secretions reduce, and headache disappears or alleviates.The Radix Astragali has benefiting QI for strengthening the superficies, arresting sweating admittedly to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema.It is weak to be used for the treatment of the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating is given birth to consolidating superficial resistance holder skin ulcer.The Herba Equiseti Hiemalis is Equisetaceae plant Herba Equiseti Hiemalis's herb.Gather summer, removes impurity, dries or dry in the shade, and cuts off section.Herba Equiseti Hiemalis's main product in northeast, North China, the Inner Mongol and each province, the Yangtze river basin.The dark and damp place of hillside sylvan life is born in former plant happiness, easily gives birth to riparian wetland, small stream limit, or weeds ground.Herba Equiseti Hiemalis's sweet in the mouth, hardship, property is flat.Return lung, Liver Channel, have the effect of dispelling wind and heat pathogens, improving acuity of vision and removing nebula, hemostasis.The sweet cold of Flos Lonicerae property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, and also kind removing summer-heat blood poison is used for various febrile diseases, and such as fever of the body, dermexanthesis, send out the cards such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, all effect is remarkable.The blade that lotus base of a fruit Folium Nelumbinis central authorities cut at nearly stalk place, nature and flavor are bitter flat, and the hemostasis leukorrhagia stopping has the merit of elevate a turnable ladder.Radix Pseudostellariae is mended strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Control the cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, edema is quenched one's thirst, and spirit is tired.The Flos Trollii clean taste has heat-clearing and toxic substances removing, nourishing YIN to lower pathogenic fire, the effect of replenishing YIN and removing heat and quench sterilization.Fructus Atriplicis Sibiricae suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.Be used for the dizziness due to hyperactivity of liver-YANG headache, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the diseases such as skin pruritus.Magnoliae Powder wind and cold, clearing the nasal passage.Be used for headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.Contain multivitamin in the dragon well green tea, the human homergy needs about 60 milligrams of vitamin Cs everyday approximately, can satisfy human body to the requirement of vitamin C.Strengthen human body to working as power.Chinese medicine composition dispersible tablet taking dose of the present invention is little, taking convenience, absorption is fast, bioavailability is high, easy to carry, quantitatively accurately, steady quality.

Embodiment of the invention taking dose is little, mouthfeel good, taking convenience absorb very fast, bioavailability is high, steady quality, production technology are simple.

The specific embodiment

The invention will be further described below in conjunction with specific embodiment, but not as limitation of the present invention.The part that is not described in detail in the present embodiment is to adopt prior art, and industry standard or known approaches.

Embodiment 1

Be used for the treatment of chronic pharyngitis health product granule preparation method it may further comprise the steps:

1) by following weight ratio weighting raw materials: 10 parts of Fructus Momordicaes, 30 parts of Radix Pseudostellariaes, 15 parts of Radix Codonopsis, 10 parts of Semen Sterculiae Lychnophoraes, 6 parts of Semen Oroxylis, 10 parts of Pericarpium Citri Reticulataes, 6 parts of Fructus Mumes, 6 parts in Radix Glycyrrhizae, 10 parts of Fructus Canarii albis, 10 parts on Herba Passiflorae Caeruleae stem, 20 parts of Ramulus Luffaes, 30 parts of the Radixs Astragali, 12 parts of Herba Equiseties Hiemalis, 10 parts of Flos Loniceraes, 8 parts of the lotus bases of a fruit, 6 parts of Flos Trolliis, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Flos Magnoliaes, 10 parts of dragon well green teas.

2) above 19 flavor medicines decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, gradation filtered, and merging filtrate dusts with spray dryer, and is for subsequent use;

3) dry powder described in the step 2 is added starch, anhydrous glucose, stevioside, mix homogeneously;

4) said mixture is added 80% ethanol soft material processed;

5) granulate arrangement with soft material 14 mesh sieves.

6) packing, warehouse-in get final product.

The below is the clinical observation that embodiment of the invention chronic pharyngitis health product granule is used for the treatment of chronic pharyngitis:

1 data and method

1.1 physical data

Patients with chronic pharyngitis 240 people that selection is received treatment voluntarily, wherein: male 101 people, women 139 people, age distribution was at 16 ~ 62 years old, and 44.1 years old mean age, patient's course of disease did not wait in 1 ~ 8 year.Patient respectively symptom is the acute pharyngitis history of repeated attack, or because of the long-term mouth breathing of cacorhinia and the pharyngitis symptom that causes of the reason such as tobacco and wine are excessive, surrounding air is dry, dust and irritative gas pollution.Be divided at random matched group, treatment group 1, treatment group 2, treatment group 3, every group of 60 examples; Each is organized the patient age symptom and consists of without significant difference.Has comparability (P〉0.05).

1.2 Therapeutic Method

The treatment group Primary Care is consistent, and matched group is not taken medicine.The A group embodiment of the invention 1,1 bag of every day twice, one time, 10 ~ 15 is a course for the treatment of.B group is with Beijing Tongrentang LIYANLING PIAN, one time 3,3 times on the one; C group FUFANG CAOSHANHU HANPIAN, Jiangzhong Pharmaceutical Co., Ltd.'s production, one time 2, every 2 hours once, 6 times on the one.

2 results

2.1 curative effect determinate standard

Recovery from illness: without recurrence, checked that red swelling of the pharynx disappeared with interior clinical symptoms and sign disappearance more than 1 year, and swallowed the rear wall lymph follicle and recover normal in 3 months with interior sx↓ in 10 days; Produce effects: two weeks is with interior sx↓, disappears with interior clinical symptoms and sign in 3 months, and pharyngeal hyperemia alleviates, but curative effect do not consolidate, and the accidental cause Changes in weather speaks that too much flue dust stimulates and symptom slightly recurs, and the short-term medication is namely healed; Take a turn for the better: two weeks is with interior sx↓, and 3 months with interior clinical symptoms and the disappearance of part sign.Irritable cough reduces, and checks that the pharyngeal inflammation that still has changes; Invalid: symptom slightly has and alleviates or do not alleviate after the medication, and sign is without obvious improvement.

2.2 therapeutic outcome

	Produce effects	Take a turn for the better	Invalid	Effective percentage
					Matched group	?	?	60	0
The A group	45	11	4	93.33%
					The B group	21	30	9	85%
The C group	20	29	11	81.67%

The analysis of 3 pairs of data and discussion

Obviously contrast from upper example table, the effective percentage for the treatment of group 1 is greater than treatment group 2 and the treatment group 3 of known technology.Inefficiency is lower than treatment group 2 and the treatment group 3 of known technology.

Throat is twelve regular channels the only way which must be passed and the significant points that converges, and can interrelate by all meridians and corresponding internal organs.Therefore, the imbalance of function also can cause the discomfort of throat.In clinical, observe, though chronic pharyngitis is local patholoic change, in close relations with systemic conditions.The chronic pharyngitis etiology and pathogenesis often is that internal organs are deficient, and the consumption impairment of YIN is divided, and hyperactivity of deficient fire causes in throat, or repeatedly shows effect because of acute pharyngitis due to wind-heat, remaining evil delay the, or dust, foul smell stimulates, and the hobby tobacco and wine are pungent, impairment caused by overstrain excessively waits and causes that deficiency of lung-YIN is deficiency of body fluid then, and it is foster that throat loses in moistening, furthermore asthenic fire.Follow through upper inflammation; Deficiency of the kidney yin, network is in lung on the passages through which vital energy circulates of kidney, and deficiency of the kidney yin whenever causes the also deficiency of YIN of lung, and hyperactivity of deficient fire is satisfied to sore throat.In addition, steam on the asthenic fire, bright Tianjin becomes expectorant, in addition venation numbness resistance, and disorder of QI movement, it is solidifying to cause stagnation of QI expectorant, phlegm-fire pent-up.Adopt the Chinese medicine composition supplementing QI and nourishing YIN, relieving sore throat and pain reaches the healing purpose.And then illustrate that embodiment 1 affiliated prescription is reliably effective in this invention.

The patient suffers from simultaneously rhinitis and has also obtained effective healing in the treatment group 1, because the present invention considers causing by many reasons such as self and environment of pharyngitis and causes, and cause that because rhinitis causes long-term mouth breathing pharyngitis also belongs to common, Mrs Chai in the treatment group 1,48 years old age, for many years pharyngitis puzzlement, suffer from simultaneously sinusitis and often cause that headache, sinusitis are the accomplices of Mrs's Chai pharyngitis through examining, through taking the embodiment of the invention 1,10 days first meeting effects, sinusitis and headache alleviate, and the pharyngitis symptom is clearly better, not only pharyngitis recovery from illness two courses for the treatment of, sinusitis also is almost recovered, and headache also disappears substantially.Nothing recurrence after 1 year.

Claims (2)

1. treatment chronic pharyngitis health product granule is characterized in that crude drug composition and weight proportion thereof that it contains are: 10 parts of Fructus Momordicaes, 30 parts of Radix Pseudostellariaes, 15 parts of Radix Codonopsis, 10 parts of Semen Sterculiae Lychnophoraes, 6 parts of Semen Oroxylis, 10 parts of Pericarpium Citri Reticulataes, 6 parts of Fructus Mumes, 6 parts in Radix Glycyrrhizae, 10 parts of Fructus Canarii albis, 10 parts on Herba Passiflorae Caeruleae stem, 20 parts of Ramulus Luffaes, 30 parts of the Radixs Astragali, 12 parts of Herba Equiseties Hiemalis, 10 parts of Flos Loniceraes, 8 parts of the lotus bases of a fruit, 6 parts of Flos Trolliis, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Flos Magnoliaes, 10 parts of dragon well green teas.

The preparation method for the treatment of chronic pharyngitis health product granule it may further comprise the steps:

1) by following weight ratio weighting raw materials: 10 parts of Fructus Momordicaes, 30 parts of Radix Pseudostellariaes, 15 parts of Radix Codonopsis, 10 parts of Semen Sterculiae Lychnophoraes, 6 parts of Semen Oroxylis, 10 parts of Pericarpium Citri Reticulataes, 6 parts of Fructus Mumes, 6 parts in Radix Glycyrrhizae, 10 parts of Fructus Canarii albis, 10 parts on Herba Passiflorae Caeruleae stem, 20 parts of Ramulus Luffaes, 30 parts of the Radixs Astragali, 12 parts of Herba Equiseties Hiemalis, 10 parts of Flos Loniceraes, 8 parts of the lotus bases of a fruit, 6 parts of Flos Trolliis, 12 parts of Fructus Atriplicis Sibiricaees, 10 parts of Flos Magnoliaes, 10 parts of dragon well green teas;

2) above 19 flavor medical materials decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, gradation filtered, and merging filtrate dusts with spray dryer, and is for subsequent use;

3) dry powder described in the step 2 is added starch, anhydrous glucose, stevioside, mix homogeneously;

4) said mixture is added 80% ethanol soft material processed;

5) granulate arrangement with soft material 14 mesh sieves;

6) packing, warehouse-in get final product.