CN102579663A - Chinese medicinal composition for treating wind-heat type common cold and preparation method thereof - Google Patents
Chinese medicinal composition for treating wind-heat type common cold and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal composition for treating wind-heat type common cold and a preparation method thereof. The Chinese medicinal composition is prepared from the following Chinese medicines which are homologous in medicines and food: honeysuckle, mint, mulberry leaf, chrysanthemum morifolium ramat and heartleaf houttuynia herb, and a Chinese medicinal oral preparation prepared from the Chinese medicinal composition has an obvious effect of treating wind-heat type common cold and a good curative effect, does not have toxic or side effects, and is wide in applicable people.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition of treating flu and preparation method thereof.
Background technology
Flu is commonly called as cold, be the thoughts and feelings ailment said due to cold or exposure or the time row virus cause that lung defends the disease of functional disorder, all can fall ill throughout the year; Comprise a series of diseases caused by exogenous pathogenic factor symptoms such as nasal obstruction, watery nasal discharge, sneeze, headache, aversion to cold, heating, general malaise, see with winter and spring more especially, have some inkling of a cold and see nasal meatus and Wei Biao symptom more; Itch or uncomfortable as nasopharynx part is dried, secondary is heatable, pharyngalgia, the heavy discomfort of podomere acid etc., for influenza; Can be popular, many people are sudden onset simultaneously, easily rapid spread.
Common cold treatment medicine on the market generally is divided into two types, and one type is Western medicine, and its treatment onset is very fast but side effect is bigger, and price is high; Normal dialectical the dividing and ruling of Chinese medicine flu comprises wind-cold syndrome, wind-heat syndrome, syndrome of summer-heat-dampness, syndrome of superficies cold and interior heat etc., and anemopyretic cold is due to evil criminal's table, the lung qi of wind heat become estranged.Symptom shows as heating weight, micro evil wind, distending pain in the head, antiperspirant, red swelling and pain of throat, cough, expectorant sticking or yellow, have a stuffy nose yellow thick nasal discharge, thirst and liking drink, red, the little Huang of white and thin fur in the tip of the tongue limit is arranged." General Treatise on the Cause and Symptoms of Diseases wind heat time ": " wind heat patient, the gas of wind heat are gone into lung also from fur earlier.Lung is the five internal organs loam cake, waits the fur of body, if the skin natural fibre line of meat is empty, then the gas of wind heat is hindered fur earlier, is into lung also.Its shape makes the shiver with cold of people's aversion to wind, and order is desired to take off, and tears saliva goes out." control suitable relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, disperse wind heat.The side is diffusing with Lonicerae and Forsythiae Powder, SANGJU YIN, Radix Platycodonis decoction, supernatant, chrysanthemum powder forimproving etc.If heal for a long time and not, its people must be empty, must not special-purposely evacuate.Yang deficiency should add ginseng, art, and the deficiency of YIN should add Radix Rehmanniae, the five tastes, times Radix Ophiopogonis, the Radix Paeoniae Alba.Though the side effect of above-mentioned common anemopyretic cold treatment Chinese medicine is less; But curative effect is general, and because wherein more or less contain some bitter different article, or because part kind flavour of a drug strong flavor difficulty on the high side, the acceptance level on the market is in reduction gradually; Therefore, be necessary to develop that a kind of side effect is little, the Chinese medicine of good effect and taking convenience.
Flos Lonicerae: sweet, cold.Return lung, the heart, stomach warp.Function with cure mainly: heat-clearing and toxic substances removing, dispelling wind and heat pathogens.Be used for the carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.Main component: 1. chlorogenic acid: 2. glycoside: glycosides composition comprises Saponin, iridoid glycoside etc.3. flavonoid: 5-hydroxyl-3 ' is arranged; 4,7-trimethoxy flavone, luteolin-7-O-a-D-glycoside, luteolin-7-O-b-D-galactoside, Quercetin-3-O-b-D-glycoside, hyperin etc. are volatile oil 4.: main constituent is the pure and mild linalool of Flos Lonicerae.
Herba Menthae: suffering, cold.Return lung, Liver Channel.Function with cure mainly: dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, soothing the liver circulation of qi promoting.Be used for anemopyretic cold, pathogenic wind-warm from the beginning of, the headache, conjunctival congestion, sore throat, aphtha, rubella, measles.Breast side of body feeling of distension and oppression.Main component: volatile oil: be mainly menthol, content reaches 77%-78%, and other also has menthone, menthyl acetate etc.
Folium Mori: sweet, hardship, cold.Return lung, Liver Channel.Dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.Be used for anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.Main component: 1. sterols: be mainly inokosterone, hydroxy ecdysterone, cupreol one β-glycoside, cupreol.2. flavone and flavonoid glycoside: be mainly globulariacitrin, other has Mulberry glycoside, Isoquercitrin etc.3. alkaloids is mainly gynesin, choline, 4. the polysaccharide polysaccharides of Folium Mori can be with blood glucose in gland fast mountain range.5. other classes mainly contain volatile oil, and several amino acids, vitamin etc.
Flos Chrysanthemi: sweet, hardship is slightly cold.Return lung, Liver Channel.Function with cure mainly: the wind heat clearing away of loosing, suppressing the hyperactive liver makes eye bright, heat-clearing and toxic substances removing.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted, sore and toxic.Main component: 1. volatile oil: be mainly Borneolum Syntheticum, Camphora, chrysanthenone.2. flavonoid is mainly diosmetin, luteolin, apigenin.Acacetin etc.3. other types contain 17 seed amino acids, and wherein 8 kinds is the human body essential amino acid, also contains the trace element of needed by human, and copper, ferrum, zinc etc. also contain chlorogenic acid.
Herba Houttuyniae: suffering is slightly cold.Return lung meridian.Function with cure mainly: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.Be used for the lung abscess vomiting pus, the expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.Main component: volatile oil: be mainly and contain the antibiotic effective ingredient decanoylacetaldehyde, usually said houttuynine sodium bisulfite refers to the addition product of the sodium sulfite of capric acid acetaldehyde.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of treating anemopyretic cold, process by Flos Lonicerae, Herba Menthae, Folium Mori, Flos Chrysanthemi, Herba Houttuyniae.
A kind of Chinese medicine composition of treating anemopyretic cold of the present invention, its raw material weight ratio of processing drug effect is:
Flos Lonicerae 10-20 part, Herba Menthae 5-15 part, Folium Mori 15-25 part, Flos Chrysanthemi 5-15 part, Herba Houttuyniae 5-15 part.
A kind of Chinese medicine composition of treating anemopyretic cold of the present invention is characterized in that, the raw material weight ratio of processing drug effect is preferably:
15 parts of Flos Loniceraes, 10 parts of Herba Menthaes, 20 parts on Folium Mori, 10 parts of Flos Chrysanthemi, 10 parts of Herba Houttuyniae.
Another object of the present invention is to provide the method for preparing of the Chinese medicine composition of treating anemofrigid cold as stated; It is characterized in that, process: Flos Lonicerae 10-20 part, Herba Menthae 5-15 part, Folium Mori 15-25 part, Flos Chrysanthemi 5-15 part, Herba Houttuyniae 5-15 part by the pharmacodynamic raw materials of following weight portion.
The method for preparing of Chinese medicine composition of the present invention is characterized in that, may further comprise the steps:
(1) above-mentioned parts by weight of Chinese traditional medicine material is dropped in the extraction pot, add the ethanol that 8-12 doubly measures 60%-80%, heating refluxes, extract 2-3 time, and each 1-2 hour, filter and obtain alcohol extract, merge alcohol extract, stand for standby use;
(2) filtering residue that above-mentioned filtration is obtained adds 8-12 times of water by volume, decocts 3 times, and each 30-60 minute, merge aqueous extract, aqueous extract is for use, and medicinal residues discard;
(3) the alcohol extract decompression recycling ethanol after will merging is not to there being the alcohol flavor, the alcohol extraction concentrated solution, alcohol extraction concentrated solution and aqueous extract are merged, continue concentrated mixed extraction concentrated solution;
(4) mixed extraction concentrated solution drying under reduced pressure is pulverized, and is subsequent use.
The method for preparing of Chinese medicine composition of the present invention is characterized in that, comprises following preferred steps:
(1), above-mentioned parts by weight of Chinese traditional medicine material is dropped in the extraction pot, add 8-12 and doubly measure 70% ethanol, heating; Pick up counting after the backflow beginning, extracted 2 hours, cross and filter alcohol extract 1; Filtering residue extracts 2 times with method, filters to obtain alcohol extract 2, alcohol extract 3, and alcohol extract merges stand for standby use;
(2), filtering residue that above-mentioned filtration is obtained adds 8-12 times of water by volume, decocts 3 times, each 30 minutes, the merging aqueous extract, aqueous extract is for use, medicinal residues discard;
(3), the alcohol extract after will merging at 75 ℃ of following decompression recycling ethanols to there not being the alcohol flavor, alcohol extract, with alcohol extraction concentrated solution and the merging of water extract, continue to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution;
(4), mixed extraction concentrated solution drying under reduced pressure under 50 ℃, the condition of vacuum 0.10MPa, to moisture below 5%, pulverize, cross 40 mesh sieves, fine powder is subsequent use.
Another object of the present invention is to provide peroral dosage forms such as a kind of tablet of treating anemopyretic cold, capsule, granule.
Chinese medicine composition of the present invention has following advantage:
1, all medical materials of Chinese medicine composition of the present invention are the integration of edible and medicinal herbs kind, no hormone, have no side effect, and taking convenience, effect is remarkable.
2, Chinese medicine composition of the present invention is taken into account the protection and the coordination of the function of the heart, liver, lung, spleen, kidney, has demonstrated fully Chinese medicine organic conception and advantage, makes the more comprehensive and treating both the principal and secondary aspects of a disease of drug effect and function.
3, the peroral dosage forms of being processed by above five kinds of Chinese medicine such as granule, treatment anemopyretic cold effect is remarkable.
The specific embodiment
Following embodiment is used to further specify the present invention, but does not limit the present invention.
Drug effect embodiment
(1) embodiment 1 for preparing among the embodiment with the present invention is that example is carried out clinical trial, and diagnostic criteria wherein is:
Anemopyretic cold symptom: primary symptom: fever of the body work, micro evil wind, antiperspirant is let out smooth, parched throat, throat tonsillitis congestion and swelling pain, nasal obstruction, stream turbid nasal discharge, the floating number of pulse condition;
Inferior disease: distending pain in the head, cough, the expectoration Huang is thick, thirst with desire to drink, the little Huang of thin white fur of tongue, and the limit point is red.
Criterion of cure: treat 3 days normal with interior temperature recovery, cold symptoms all disappears;
The produce effects standard: treat 3 days normal with interior body temperature, most of transference cure of flu;
Effective standard: treat and reduced than before with interior body temperature in 3 days, the cardinal symptom of flu partly disappears;
Invalid standard: treat and do not fall with interior body temperature or raise in 3 days, the cardinal symptom of flu does not have improvement.
Totally 60 of the patients at different sexes, age, one group of 30 people are divided into 2 groups, one group with traditional Chinese medicine composition for treating of the present invention as experimental group, another the group with golden antelope KANGGAN JIAONANG as matched group,
The experimental group result is following:
Matched group
The result shows that the experimental group curative effect is superior to matched group
(2) embodiment 3 for preparing among the embodiment with the present invention carries out clinical trial, and case is given an example:
All XX, the man, 35 years old, before the treatment, rhinorrhea, cough, headache, nasal obstruction, 38 ℃ of body temperature after the administration, were seen the nasal obstruction alleviation in 1 day, and body temperature descends, and cough alleviates, and administration is after 2 days, and body temperature is normal, and cold symptoms disappears basically.
Wu X, the woman, 45 years old, before the treatment, nasal obstruction stream yellow thick nasal discharge was afraid of cold, little coughing, 37.3 ℃ of body temperature after the administration, were seen the nasal obstruction alleviation in 1 day, and body temperature descends, and administration is after 2 days, and body temperature is normal, and cold symptoms disappears.
Lee XX, the man, 25 years old, before the treatment, a large amount of yellow thick nasal discharge of cough stream of having a stuffy nose,, the headache pain, 38.5 ℃ of body temperature after the administration, were seen the nasal obstruction alleviation in 1 day, and body temperature descends, and cough alleviates, and administration is after 3 days, and body temperature is normal, and cold symptoms disappears basically.
Preparation embodiment
Embodiment 1
Flos Lonicerae 15g, Herba Menthae 10g, Folium Mori 20g, Flos Chrysanthemi 10g, Herba Houttuyniae 10g, the good medical material of weighing drops in the extraction pot, adds 8-12 and doubly measures 70% ethanol; Heating picks up counting after the beginning that refluxes, and extracts 2h; Cross and filter alcohol extract 1, filtering residue extracts 2 times with method, filters and obtains alcohol extract 2, alcohol extract 3; Alcohol extract merges, stand for standby use.To filter the gained filtering residue and add 8-12 times of water by volume, decoct 3 times, each 30 minutes, merge aqueous extract, for use, medicinal residues discard.With the 75 ℃ of decompression recycling ethanols of alcohol extract after merging to there not being the alcohol flavor, the alcohol extraction concentrated solution, merge alcohol extraction concentrated solution and water extract, continue to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution.Mixed extraction concentrated solution drying under reduced pressure (the drying under reduced pressure condition is 50 ℃, vacuum 0.10MPa) to moisture is pulverized below 5%, crosses 40 mesh sieves, and fine powder is subsequent use.Use the aspartame of the extract dry powder that mixes and 0.1%, 0.2% magnesium stearate, 0.3%CMC-Na with the equivalent method mix homogeneously that progressively increases.With 80% ethanol system soft material, 16 mesh sieves are granulated, 20 mesh sieve granulate after 40 ℃ of oven dry with mixed powder.Be pressed into the tablet of certain specification with tablet machine.
Embodiment 2
Flos Lonicerae 300g, Herba Menthae 200g, Folium Mori 400g, Flos Chrysanthemi 200g, Herba Houttuyniae 200g, the good medical material of weighing drops in the extraction pot, adds 8-12 and doubly measures 70% ethanol; Heating picks up counting after the beginning that refluxes, and extracts 2h; Cross and filter alcohol extract 1, filtering residue extracts 2 times with method, filters and obtains alcohol extract 2, alcohol extract 3; Alcohol extract merges, stand for standby use.To filter the gained filtering residue and add 8-12 times of water by volume, decoct 3 times, each 30 minutes, merge aqueous extract, for use, medicinal residues discard.With the alcohol extract after merging at 75 ℃ of decompression recycling ethanols to there not being the alcohol flavor, the alcohol extraction concentrated solution, merge alcohol extraction concentrated solution and water extract, continue to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution.Mixed extraction concentrated solution drying under reduced pressure (the drying under reduced pressure condition is 50 ℃, vacuum 0.10MPa) to moisture is pulverized below 5%, crosses 40 mesh sieves, and fine powder is subsequent use.Use aspartame, 0.2% magnesium stearate, the 0.3%CMC-Na equivalent of the extract dry powder that mixes and the 0.1% method mix homogeneously that progressively increases.With 80% ethanol system soft material, 16 mesh sieves are granulated, 20 mesh sieve granulate after 40 ℃ of oven dry with mixed powder.Incapsulate, get capsule.
Embodiment 3
Flos Lonicerae 600g, Herba Menthae 400g, Folium Mori 800g, Flos Chrysanthemi 400g, Herba Houttuyniae 400g, the good medical material of weighing drops in the extraction pot, adds 8-12 and doubly measures 70% ethanol; Heating picks up counting after the beginning that refluxes, and extracts 2h; Cross and filter alcohol extract 1, filtering residue extracts 2 times with method, filters and obtains alcohol extract 2, alcohol extract 3; Alcohol extract merges, stand for standby use.To filter the gained filtering residue and add 8-12 times of water by volume, decoct 3 times, each 30 minutes, merge aqueous extract, for use, medicinal residues discard.With the alcohol extract after merging at 75 ℃ of decompression recycling ethanols to there not being the alcohol flavor, the alcohol extraction concentrated solution, merge alcohol extraction concentrated solution and water extract, continue to be concentrated into relative density and be 1.2～1.25 mixed extraction concentrated solution.Mixed extraction concentrated solution drying under reduced pressure (the drying under reduced pressure condition is 50 ℃, vacuum 0.10MPa) to moisture is pulverized below 5%, crosses 40 mesh sieves, and fine powder is subsequent use.Use the aspartame of the extract dry powder that mixes and 0.1%, 0.2% magnesium stearate, 0.3%CMC-Na, 0.5% the orange flavor equivalent method mix homogeneously that progressively increases.With 80% ethanol system soft material, 16 mesh sieves are granulated, 20 mesh sieve granulate after 40 ℃ of oven dry with mixed powder.Get granule.
Embodiment 4
Each flavor Chinese medicine is smashed to pieces; Cross 10 mesh sieves, extracting honeysuckle 20g, Herba Menthae 15g, Folium Mori 25g, Flos Chrysanthemi 15g, Herba Houttuyniae 15g add 12 times and measure 80% alcohol reflux 2h successively; Cross and filter extracting solution 1; Filtering residue extracts 2 times with method, filters to obtain extracting solution 2, extracting solution 3, and extracting solution merges stand for standby use; To filter the gained filtering residue and add 8-12 times of water by volume, decoct 3 times, each 30 minutes, merge aqueous extract, for use, medicinal residues discard.75 ℃ of decompression recycling ethanols of merge extractive liquid, to there not being the alcohol flavor, are merged alcohol extraction concentrated solution and water extract, continue to be concentrated into relative density and be 1.24 mixed extraction concentrated solution; 50 ℃ of mixed extraction concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 3% is pulverized; Cross 40 mesh sieves, fine powder is subsequent use; With the aspartame of the extract dry powder that mixes and 0.1%, 0.2% magnesium stearate, 0.3%CMC-Na, 0.5% orange flavor with the equivalent method mix homogeneously that progressively increases; With mixed powder with 80% ethanol system soft material; 16 mesh sieves are granulated, and 20 mesh sieve granulate are subsequent use after 40 ℃ of oven dry; With above-mentioned granule tabletting, average sheet heavily is 1.40g, promptly gets pharmaceutical composition tablet of the present invention.
Embodiment 5
Each flavor Chinese medicine is smashed to pieces; Cross 10 mesh sieves, extracting honeysuckle 10g, Herba Menthae 15g, Folium Mori 15g, Flos Chrysanthemi 15g, Herba Houttuyniae 5g add 9 times and measure 60% alcohol reflux 2h successively; Cross and filter extracting solution 1; Filtering residue extracts 2 times with method, filters to obtain extracting solution 2, extracting solution 3, and extracting solution merges stand for standby use; To filter the gained filtering residue and add 8-12 times of water by volume, decoct 3 times, each 30 minutes, merge aqueous extract, for use, medicinal residues discard.75 ℃ of decompression recycling ethanols of merge extractive liquid, to there not being the alcohol flavor, are merged alcohol extraction concentrated solution and water extract, and continuing to be concentrated into relative density is 1.2; 2 mixed extraction concentrated solution; 50 ℃ of mixed extraction concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 2% is pulverized; Cross 40 mesh sieves, fine powder is subsequent use; With the aspartame of the extract dry powder that mixes and 0.1%, 0.2% magnesium stearate, 0.3%CMC-Na, 0.5% orange flavor with the equivalent method mix homogeneously that progressively increases; With mixed powder with 80% ethanol system soft material; 16 mesh sieves are granulated, and 20 mesh sieve granulate are subsequent use after 40 ℃ of oven dry; With above-mentioned granule tabletting, average sheet heavily is 1.40g, promptly gets pharmaceutical composition tablet of the present invention.
Embodiment 6
Each flavor Chinese medicine is smashed to pieces; Cross 10 mesh sieves, extracting honeysuckle 14g, Herba Menthae 8g, Folium Mori 18g, Flos Chrysanthemi 12g, Herba Houttuyniae 10g add 8-12 and doubly measure 65% alcohol reflux 1.5h successively; Cross and filter extracting solution 1; Filtering residue extracts 2 times with method, filters to obtain extracting solution 2, extracting solution 3, and extracting solution merges stand for standby use; To filter the gained filtering residue and add 8-12 times of water by volume, decoct 3 times, each 30 minutes, merge aqueous extract, for use, medicinal residues discard.75 ℃ of decompression recycling ethanols of merge extractive liquid, to there not being the alcohol flavor, are merged alcohol extraction concentrated solution and water extract, and continuing to be concentrated into relative density is 1.2; 3 mixed extraction concentrated solution; 50 ℃ of mixed extraction concentrated solutions, vacuum 0.10MPa drying under reduced pressure to moisture 2% is pulverized; Cross 40 mesh sieves, fine powder is subsequent use; With the aspartame of the extract dry powder that mixes and 0.1%, 0.2% magnesium stearate, 0.3%CMC-Na, 0.5% orange flavor with the equivalent method mix homogeneously that progressively increases; With mixed powder with 80% ethanol system soft material; 16 mesh sieves are granulated; 20 mesh sieve granulate after 40 ℃ of oven dry promptly get medicament composition granule agent of the present invention.
Embodiment 7
Each flavor Chinese medicine is smashed to pieces; Cross 10 mesh sieves, extracting honeysuckle 16g, Herba Menthae 10g, Folium Mori 20g, Flos Chrysanthemi 8g, Herba Houttuyniae 12g add 10 times and measure 70% alcohol reflux 1.5h successively; Cross and filter extracting solution 1; Filtering residue extracts 2 times with method, filters to obtain extracting solution 2, extracting solution 3, and extracting solution merges stand for standby use; To filter the gained filtering residue and add 8-12 times of water by volume, decoct 3 times, each 30 minutes, merge aqueous extract, for use, medicinal residues discard.75 ℃ of decompression recycling ethanols of merge extractive liquid, are not distinguished the flavor of to there being alcohol; Merge alcohol extraction concentrated solution and water extract, continue to be concentrated into relative density and be 1.24 mixed extraction concentrated solution, 50 ℃ of mixed extraction concentrated solutions; Vacuum 0.10MPa drying under reduced pressure to moisture 2.5%; Pulverize, cross 40 mesh sieves, fine powder is subsequent use; With the aspartame of the extract dry powder that mixes and 0.1%, 0.2% magnesium stearate, 0.3%CMC-Na, 0.5% orange flavor with the equivalent method mix homogeneously that progressively increases; With mixed powder with 80% ethanol system soft material; 16 mesh sieves are granulated, and 20 mesh sieve granulate are subsequent use after 40 ℃ of oven dry; With above-mentioned granule tabletting, average sheet heavily is 1.40g, promptly gets pharmaceutical composition tablet of the present invention.
Determination of total flavonoids
1. reagent
Ethanol: analytical pure
Methanol: analytical pure
Diluted Alcohol: get ethanol 529ml, thin up promptly gets to 1000ml.In the time of 20 ℃, contain C
2H
50H should be 49.5%-50.5%.
Deionized water
Reference substance solution: precision takes by weighing control substance of Rutin 0.00143g, and dissolve with methanol also is settled to the 10ml volumetric flask, as storing solution, promptly gets.
2. instrument and equipment
Ultraviolet-uisible spectrophotometer
Ultrasonic washing instrument
3. operating procedure
3.1 sample is handled
Get 6 in tablet, porphyrize.Take by weighing the sample of a certain amount of (about 3g), put in the tool plug conical flask, add about 20ml Diluted Alcohol solution, claim to decide weight; Supersound extraction 1 hour is supplied the weight that subtracts mistake with Diluted Alcohol, shakes up, and filters; Get subsequent filtrate, precision is measured 25 μ l, puts in the 10ml measuring bottle; Add methanol to scale, shake up, as need testing solution.
3.2 standard curve
In the reference substance 0.3,0.6,0.9,1.2 of accurate respectively absorption 0.143mg/ml, 1.5ml to the 10ml volumetric flask, add methanol to scale standardize solution, shake up.Respectively getting in right amount in colorimetric pool, is blank with methanol, according to ultraviolet visible spectrophotometry, measures absorbance at the 361nm wavelength, asks regression equation.
3.3 sample detection
Getting need testing solution respectively in right amount in colorimetric pool, is blank with methanol, according to ultraviolet visible spectrophotometry, measures absorbance at the 361nm wavelength, calculates content of total flavone in the test sample by standard curve.
3.4 result
Standard curve: A=0.027C+0.016, R2=0.999
General flavone content >=2.18%.
Claims (5)
1. a Chinese medicine composition of treating anemopyretic cold is characterized in that, is processed by Flos Lonicerae, Herba Menthae, Folium Mori, Flos Chrysanthemi and Herba Houttuyniae.
2. the Chinese medicine composition of treatment anemopyretic cold as claimed in claim 1 is characterized in that, is processed by following parts by weight of Chinese traditional medicine: Flos Lonicerae 10-20 part, Herba Menthae 5-15 part, Folium Mori 15-25 part, Flos Chrysanthemi 5-15 part, Herba Houttuyniae 5-15 part.
3. like the Chinese medicine composition of the arbitrary described treatment anemopyretic cold of claim 1-2, it is characterized in that, process: 15 parts of Flos Loniceraes, 10 parts of Herba Menthaes, 20 parts on Folium Mori, 10 parts of Flos Chrysanthemi, 10 parts of Herba Houttuyniae by following parts by weight of Chinese traditional medicine.
4. like the method for preparing of the arbitrary Chinese medicine composition of claim 1-3, it is characterized in that, may further comprise the steps:
(1) above-mentioned parts by weight of Chinese traditional medicine material is dropped in the extraction pot, add the ethanol that 8-12 doubly measures 60%-80%, heating refluxes, extract 2-3 time, and each 1-2 hour, filter and obtain alcohol extract, merge alcohol extract, stand for standby use;
(2) filtering residue that filtration is obtained adds 8-12 times of water by volume, decocts 3 times, and each 30-60 minute, merge aqueous extract, aqueous extract is for use, and medicinal residues discard;
(3) alcohol extract after will merging at 75 ℃ of following decompression recycling ethanols to there not being the alcohol flavor, the alcohol extraction concentrated solution, alcohol extraction concentrated solution and aqueous extract are merged, continue concentrated mixed extraction concentrated solution;
(4) mixed extraction concentrated solution drying under reduced pressure is pulverized.
5. like the Chinese medicine composition of the arbitrary described treatment anemopyretic cold of claim 1-3, it is characterized in that: the dosage form of described Chinese medicine composition is tablet, capsule, granule.
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| CN106668169A (en) * | 2016-12-29 | 2017-05-17 | 唐才才 | Drug for treating wind-heat type common cold and preparation method thereof |
| CN108355059A (en) * | 2018-05-24 | 2018-08-03 | 亳州市永刚饮片厂有限公司 | Treat anemopyretic cold Chinese medicine composition with and preparation method thereof |
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Application publication date: 20120718 |