CN102068480A - Edible and medicinal compound preparation with effects of heatstroke alleviation and detoxification - Google Patents
Edible and medicinal compound preparation with effects of heatstroke alleviation and detoxification Download PDFInfo
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- CN102068480A CN102068480A CN2010102055091A CN201010205509A CN102068480A CN 102068480 A CN102068480 A CN 102068480A CN 2010102055091 A CN2010102055091 A CN 2010102055091A CN 201010205509 A CN201010205509 A CN 201010205509A CN 102068480 A CN102068480 A CN 102068480A
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Abstract
The invention relates to an edible and medicinal natural plant compound preparation with the effects of heatstroke alleviation and detoxification, in particular to a compound preparation containing honeysuckle and chrysanthemum. The compound preparation includes 1-100g of honeysuckle and 1-100g of chrysanthemum, and also includes 1%-99% of honeysuckle extract and 1%-99% of chrysanthemum extract. The invention further includes pharmaceutically-acceptable oral drug dosage forms and oral health care product dosage forms suitable for clinical use which are prepared from various auxiliary materials. The invention achieves the effects of heatstroke alleviation and detoxification, as well as pharmacological effects including bacteria resistance, inflammation diminishment, antipyresis, liver protection, lipid regulation and the like. The compound preparation provided by the invention is applied to heatstroke, heat preservation of viscerae, poor health, thirsty and polydipsia, or applied to epidemic propagation, pyrexia and thirsty.
Description
Technical field
The present invention is a kind of food and medicament dual-purpose natural plant compound formulation, specifically is the preparation that contains Flos Lonicerae, Flos Chrysanthemi, have clearing away summer-heat, antidotal effect and antibiotic, antiinflammatory, analgesic, protect the liver, transfer fat, regulate pharmacological actions such as immunity.
Background technology
Flos Lonicerae is a Flos Lonicerae, is the food and medicament dual-purpose plant from ancient times to the present, can go into prescription for tea-drinking.Flos Lonicerae is sweet in flavor and cold in property, and effect dispelling wind and heat pathogens, clearing away heat-fire, expelling summer-heat, detoxifcation are usually used in treating the heated term to be heated, anemopyretic cold, epidemic febrile disease heating, toxic-heat and blood stasis, sore swollen toxin etc.Modern pharmacological research shows, effect such as that Flos Lonicerae has is analgesic, antibacterial, antiviral, antiinflammatory, adjusting immunity.Modern clinical prevention and the treatment that is used for special diseases of viral infection such as SARS, swine flu, respond well.
Flos Chrysanthemi, sweet in the mouth cold in nature, energy wind and heat dispersing, liver heat removing and eyesight improving, expelling summer-heat.Also be the food and medicament dual-purpose plant, since ancient times or for tea-drinking, or go into prescription, be used for removing summer-heat, or treatment anemopyretic cold, hepatic and renal YIN deficiency blurring of vision.Modern pharmacological research shows, Flos Chrysanthemi is to common virus such as influenza virus, and multiple pathogen such as staphylococcus aureus, diphtheria corynebacterium, Bacillus typhi, escherichia coli all have stronger inhibitory action, also has blood pressure lowering, effects such as antiinflammatory, enhancing immunity.
Summary of the invention
The present invention is according to tcm treatment according to syndrome differentiation, and the principle of principle-method-recipe-medicines needs prescription to form by its effect, has the effect of clearing away summer-heat, detoxifcation.Be used for the heatstroke in summer, internal organs have heat, and are uncomfortable, thirsty polydipsia; Or it is popular to be used for pestilent toxicity, heating, and mouth is drunk.Unless otherwise indicated, the part term of this description is defined as follows:
Flos Lonicerae: or its crude drug, be meant the dry flower of caprifoliaceae plant Radix Ophiopogonis (Lonicera japonica Thunb.) or be with the flower of just opening, or by caprifoliaceae plant dry flower or the first tcm and herbal slice of opening of spending making of band of Radix Ophiopogonis.Be used for when of the present invention, it can be ground into coarse powder so that extract.
Flos Chrysanthemi: or its crude drug, be meant the dry capitulum of feverfew chrysanthemum (Chrysanthemum morifolium Ramat.), or the tcm and herbal slice that is made into by the dry capitulum of feverfew chrysanthemum.Be used for when of the present invention, it can be ground into coarse powder so that extract.
The described Flos Lonicerae of food and medicament dual-purpose compound preparation refers to Chinese medicine honeysuckle and extract thereof.
The described Flos Chrysanthemi of food and medicament dual-purpose compound preparation refers to Flos Chrysanthemi medical material and extract thereof.
This compound preparation of the present invention contains Flos Lonicerae 1～100g, Flos Chrysanthemi 1～100g for per 1 part, comprises that also every part contains Flos Lonicerae extract 1%～99%, Flos Chrysanthemi extract 1%～99%.
Described food and medicament dual-purpose compound preparation has two kinds to prepare approach.One is meant that Flos Lonicerae mixes with Flos Chrysanthemi after extract the extract that step such as purification obtains; Its two be meant that Flos Lonicerae and Flos Chrysanthemi extract respectively after, then it is merged the back and obtains mixed extract.
(1) preparation of the effective ingredient water extract of described Flos Lonicerae, Flos Chrysanthemi is carried out according to following method:
A. the preparation of Flos Lonicerae extract comprises the steps:
A, Flos Lonicerae powder is broken into coarse powder, adds the water of 6 ~ 20 times (w/w), soak 0 ~ 2h, 60 ~ 100 ℃ are extracted 1 ~ 5 time, behind each 0.5 ~ 3h, and merge extractive liquid,, being concentrated into density is 1.1 ~ 1.2 (60 ℃ of surveys).
B, spissated extractum is added ethanol precipitation, get supernatant concentration, vacuum drying, crushing screening, packing.
B. the preparation of Flos Chrysanthemi extract comprises the steps:
A, Flos Chrysanthemi powder is broken into coarse powder, adds the water of 6 ~ 20 times (w/w), soak 0 ~ 2h, 60 ~ 100 ℃ are extracted 1 ~ 5 time, behind each 0.5 ~ 3h, and merge extractive liquid,, being concentrated into density is 1.1 ~ 1.2 (60 ℃ of surveys).
B, spissated extractum is added ethanol precipitation, get supernatant concentration, vacuum drying, crushing screening, packing.The extract that merges A, B gained is the compositions extract.
C. the preparation process of mixture extract is as follows:
A, Flos Lonicerae and Flos Chrysanthemi powder are broken into coarse powder, merge and mix, add the water of 6 ~ 20 times (w/w), soak 0 ~ 2h, 60 ~ 100 ℃ are extracted 1 ~ 5 time, behind each 0.5 ~ 3h, and merge extractive liquid,, being concentrated into density is 1.1 ~ 1.2 (60 ℃ of surveys).
B, spissated extractum is added ethanol precipitation, get supernatant concentration, vacuum drying, crushing screening, packing.
(2) preparation of the effective ingredient alcohol extract of described Flos Lonicerae, Flos Chrysanthemi is carried out according to following method:
A. the preparation of Flos Lonicerae extract comprises the steps:
Flos Lonicerae powder is broken into coarse powder, adds 50% ~ 90% ethanol of 6 ~ 20 times (w/w), soak 0 ~ 2h, reflux, extract, 1 ~ 5 time, behind each 0.5 ~ 3h, merge extractive liquid,, being concentrated into density is 1.1 ~ 1.2 (60 ℃ of surveys).Vacuum drying, crushing screening, packing.
B. the preparation of Flos Chrysanthemi extract comprises the steps:
Flos Chrysanthemi powder is broken into coarse powder, adds 50% ~ 90% ethanol of 6 ~ 20 times (w/w), soak 0 ~ 2h, reflux, extract, 1 ~ 5 time, behind each 0.5 ~ 3h, merge extractive liquid,, being concentrated into density is 1.1 ~ 1.2 (60 ℃ of surveys).Vacuum drying, crushing screening, packing.
The extract that merges A, B gained is the compositions extract.
C. the step of the preparation of mixture extract is as follows:
Flos Lonicerae and Flos Chrysanthemi powder are broken into coarse powder, merge and mix, add 50% ~ 90% ethanol of 6 ~ 20 times (w/w), soak 0 ~ 2h, reflux, extract, 1 ~ 5 time, behind each 0.5 ~ 3h, merge extractive liquid,, being concentrated into density is 1.1 ~ 1.2 (60 ℃ of surveys).Vacuum drying, crushing screening, packing.
Described food and medicament dual-purpose preparation can add acceptable accessories and make any oral formulations that is suitable for clinical use.
Further preferred described peroral dosage form is selected from: tablet, granule, capsule, drop pill, dispersible tablet and oral cavity quick disintegrating slice.
Described food and medicament dual-purpose preparation can add carrier up to specification and make suitable oral health product.
Further preferred described Orally taken health article is selected from: health tea, solid particle beverage, beverage, buccal tablet.
Further preferred described adjuvant comprises: excipient, filler, diluent, wetting agent, disintegrating agent, antiseptic, sweeting agent, correctives, aromatic.
The present invention be characterised in that described preparation in antibacterial, antiinflammatory, adjusting immunologic function, protect the liver, transfer the application aspect the fat.
The present invention realizes the object of the invention by implementing following technical scheme.
The specific embodiment
The following example is used to further specify invention, but scope of the present invention is not constituted any restriction.
The preparation of embodiment 1, present composition extract
1. Flos Lonicerae extract
Extracting honeysuckle 5kg, with 10 times of water extraction 3 times, extracting temperature is 90 ℃, each 1.5h.After the extracting solution mixing, it is about 1.10 (60 ℃ of surveys) that vacuum decompression is concentrated into relative density, adds ethanol and makes pure content reach 55%, and placement is spent the night, and filters drying under reduced pressure.Be ground into fine powder, cross 80 mesh sieves, packing.
2. Flos Chrysanthemi extract
Get Flos Chrysanthemi 5kg, with 20 times of water extraction 3 times, extracting temperature is 80 ℃, each 2h.After the extracting solution mixing, it is about 1.10 (60 ℃ of surveys) that vacuum decompression is concentrated into relative density, adds ethanol and makes pure content reach 55%, and placement is spent the night, and filters drying under reduced pressure.Be ground into fine powder, cross 80 mesh sieves, packing.
3. mixed extract
Extracting honeysuckle 6kg, with 10 times of water extraction 3 times, extracting temperature is 90 ℃, each 1.5h.Flos Chrysanthemi 4kg, with 20 times of water extraction 3 times, extracting temperature is 80 ℃, each 2h.After the extracting solution mixing with both, it is about 1.10 (60 ℃ of surveys) that vacuum decompression is concentrated into relative density, adds ethanol and makes pure content reach 55%, and placement is spent the night, and filters drying under reduced pressure.Be ground into fine powder, cross 80 mesh sieves, packing.
Embodiment 2, the present invention make beverage
Prescription: Flos Lonicerae 42g, Flos Chrysanthemi 36g, 1% stevioside 160ml, 0.1% citric acid 160ml.
Preparation: Flos Lonicerae and Flos Chrysanthemi are weighed, mix, add 10 times purified water, 80 ℃ are extracted twice, and merging filtrate adds an amount of chitosan, the clarification after-filtration.The citric acid and the stevioside that add in the prescription mix, and sterilization back packing makes liquid beverage.
Embodiment 3, the present invention make solid particle beverage
Prescription: the mixed extract 30g of compositions, microcrystalline Cellulose sodium 2.5g, sodium carboxymethyl cellulose 17.5g, soluble starch 30g, white dextrin 90g, stevioside 0.68g, 50% ethanol is an amount of.
Preparation: adopt conventional preparation granule technology, with the raw material that example 1 is provided, all adjuvants of getting in mixed extract 30g and the prescription mix, and 50% ethanol is as wetting agent, and granulation is sieved, and drying promptly makes the solid beverage of granule dosage form.
Embodiment 4, the present invention make buccal tablet
Prescription: Flos Lonicerae extract 1kg, Flos Chrysanthemi extract 1.5kg, Borneolum Syntheticum 20g, dextrin 100g, Oleum menthae 20g, Icing Sugar 400g, mannitol 100g, magnesium stearate 30g.
Preparation: extract is mixed, cross 100 mesh sieves.With dextrin, Icing Sugar mixing, add 85% ethanol and make soft material in right amount, cross 20 mesh sieves, granulate vacuum drying; Dried granule is crossed 20 mesh sieve granulate, adds Oleum menthae, mannitol and magnesium stearate, and mixing is pressed into conventional circular piece, promptly.
Embodiment 5, the present invention make health tea
Prescription: Flos Lonicerae 1g, Flos Chrysanthemi 1g.
Preparation: the dry product of above two components is prepared into bag tea.
Embodiment 6, the present invention make capsule
Prescription: Flos Lonicerae 5g, Flos Chrysanthemi 1g, starch 100g.
Preparation: adopt conventional preparation capsule technology, above two components are added water extraction, the water extract concentrates, the dry starch that adds mixes, and loads onto capsule shells, makes capsule.
Embodiment 7, the present invention make drop pill
Prescription: Flos Lonicerae 2g, Flos Chrysanthemi 18g.
Preparation: adopt routine preparation drop pill technology, above two components are added water extraction, the water extract concentrates, dry, pulverizing, and technology makes drop pill routinely.
Embodiment 8, the present invention make other peroral dosage form
Prescription: Flos Lonicerae 50g, Flos Chrysanthemi 50g
Preparation: the water extract of above two components adds pharmaceutics adjuvant commonly used, is prepared into oral administration solution, oral administration mixed suspension, syrup etc. according to a conventional method.
Claims (8)
1. a clearing away summer-heat, antidotal food and medicament dual-purpose compound preparation is characterized in that described preparation contains following active component: Flos Lonicerae, Flos Chrysanthemi.
2. preparation as claimed in claim 1 is characterized in that described active component adds acceptable accessories and makes the oral Pharmaceutical dosage forms that is suitable for clinical use.
3. preparation as claimed in claim 1 is characterized in that acceptable auxiliary is made Orally taken health article on the described active component adding preparation.
4. as the preparation method of claim 2～3 preparation, it is characterized in that the effective ingredient that extracts Flos Lonicerae, Flos Chrysanthemi is prepared from.
5. preparation method as claimed in claim 4 is characterized in that the preparation of Flos Lonicerae, Flos Chrysanthemi extract is carried out according to following method:
Flos Lonicerae and Flos Chrysanthemi powder are broken into coarse powder, add entry, soak 0～2h, extract 1～5 time, merge extractive liquid, concentrates, and adds ethanol precipitation again, gets supernatant concentration, vacuum drying, crushing screening, packing.
6. preparation method as claimed in claim 4 is characterized in that the preparation of Flos Lonicerae, Flos Chrysanthemi extract is carried out according to following method:
Flos Lonicerae and Flos Chrysanthemi powder are broken into coarse powder, merge and mix, add ethanol, soak reflux, extract, 1～5 time, merge extractive liquid,, vacuum drying, crushing screening, packing.
7. compound preparation as claimed in claim 1 is characterized in that per 1 part of preparation contains Flos Lonicerae 1～100g, Flos Chrysanthemi 1～100g.
8. preparation as claimed in claim 1 it is characterized in that said preparation has antibacterial, antiinflammatory, adjusting immunity, protects the liver, transfers effect such as fat, and in the heatstroke in summer, internal organs have heat, and is uncomfortable, thirsty polydipsia; The application of aspects such as or pestilent toxicity is popular, generates heat, and is thirsty.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102055091A CN102068480A (en) | 2009-11-24 | 2010-06-10 | Edible and medicinal compound preparation with effects of heatstroke alleviation and detoxification |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910191552A CN101703553A (en) | 2009-11-24 | 2009-11-24 | Summer heat-clearing and toxin-resolving product for food and medicine purposes |
| CN200910191552.4 | 2009-11-24 | ||
| CN2010102055091A CN102068480A (en) | 2009-11-24 | 2010-06-10 | Edible and medicinal compound preparation with effects of heatstroke alleviation and detoxification |
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| CN200910191552A Pending CN101703553A (en) | 2009-11-24 | 2009-11-24 | Summer heat-clearing and toxin-resolving product for food and medicine purposes |
| CN2010102055091A Pending CN102068480A (en) | 2009-11-24 | 2010-06-10 | Edible and medicinal compound preparation with effects of heatstroke alleviation and detoxification |
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| CN200910191552A Pending CN101703553A (en) | 2009-11-24 | 2009-11-24 | Summer heat-clearing and toxin-resolving product for food and medicine purposes |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102429949A (en) * | 2011-11-28 | 2012-05-02 | 四川九章生物化工科技发展有限公司 | Liver-protecting medicine or health care product composition and preparation method and application thereof |
| CN102579663A (en) * | 2012-03-20 | 2012-07-18 | 河南九势制药股份有限公司 | Chinese medicinal composition for treating wind-heat type common cold and preparation method thereof |
| CN102845574A (en) * | 2012-09-24 | 2013-01-02 | 路卫东 | Dragon boat festival tea and its making method |
| CN103263458A (en) * | 2011-11-28 | 2013-08-28 | 四川九章生物化工科技发展有限公司 | Liver-protecting medicine or health-care product composition as well as preparation method and use thereof |
| CN108125237A (en) * | 2017-12-20 | 2018-06-08 | 上海交大昂立股份有限公司 | A kind of anti-inflammatory health products of kobadrin and its preparation process |
| CN110604755A (en) * | 2019-08-06 | 2019-12-24 | 广州神农生物技术有限公司 | Antibacterial and anti-inflammatory composition and preparation method and application thereof |
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| CN106376685A (en) * | 2016-10-27 | 2017-02-08 | 贵州省贝真食业有限公司 | Plant functional health-maintaining scented tea and production process thereof |
| CN112891482B (en) * | 2020-02-20 | 2022-07-15 | 中国人民解放军总医院第五医学中心 | A composition for treating coronavirus infection |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102429949A (en) * | 2011-11-28 | 2012-05-02 | 四川九章生物化工科技发展有限公司 | Liver-protecting medicine or health care product composition and preparation method and application thereof |
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| CN102845574A (en) * | 2012-09-24 | 2013-01-02 | 路卫东 | Dragon boat festival tea and its making method |
| CN108125237A (en) * | 2017-12-20 | 2018-06-08 | 上海交大昂立股份有限公司 | A kind of anti-inflammatory health products of kobadrin and its preparation process |
| CN108125237B (en) * | 2017-12-20 | 2021-04-02 | 上海交大昂立股份有限公司 | Health product for relieving cough, eliminating phlegm and resisting inflammation and preparation process thereof |
| CN110604755A (en) * | 2019-08-06 | 2019-12-24 | 广州神农生物技术有限公司 | Antibacterial and anti-inflammatory composition and preparation method and application thereof |
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| CN101703553A (en) | 2010-05-12 |
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Application publication date: 20110525 |