CN103463503A - Medicine for removing heat from lung to relieve cough and manufacturing method - Google Patents
Medicine for removing heat from lung to relieve cough and manufacturing method Download PDFInfo
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- CN103463503A CN103463503A CN2013104536121A CN201310453612A CN103463503A CN 103463503 A CN103463503 A CN 103463503A CN 2013104536121 A CN2013104536121 A CN 2013104536121A CN 201310453612 A CN201310453612 A CN 201310453612A CN 103463503 A CN103463503 A CN 103463503A
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Abstract
A medicine for removing heat from the lung to relieve cough is made of folium mori, chrysanthemum, almonds, prunella vulgaris, mint, platycodon grandiflorum, liquorice, reed rhizome and heartleaf houttuynia. The nine traditional Chinese medicines serve as raw materials and produce a synergistic effect. The medicine can be used for anemopyretic cold, lung-heat clearing, hot eyes, headaches, cough, dryness of the mouth, dizziness and tinnitus, swollen sore throat, pulmonary abscess, phlegm-heat, dyspnea with cough, heat-type dysentery, heat stranguria, furunculosis, pyogenic infections, acute pneumonia and the like. Additionally, the nine medicines are homologous, moderate in property, capable of being taken for a long time, free of side effects, capable of being taken as both medicines and food, capable of being made into herbal tea or healthy drinks or various drug dosage forms and wide in taking range.
Description
Technical field
The present invention relates to a kind of botanical compositions of clearing away lung-heat to relieve cough, belong to the food and medicine technical field.
Background technology
Affection due to external wind and heat is due to evil criminal's table, the lung qi of wind heat become estranged, Symptoms for heating weight, micro evil wind, distending pain in the head, have that antiperspirant, red swelling and pain of throat, cough, expectorant are sticky or yellow, the yellow thick nasal discharge of having a stuffy nose, thirst and liking drink, the tip of the tongue limit are red, the micro-Huang of white and thin fur, method for the treatment of be take relieving the exterior syndrome with drugs of pungent in flavor and cool in nature as main.Affection due to external wind and heat belongs to a kind of disease of Chinese medicine, the upper respiratory tract infection that belongs to modern medicine, the common cause of disease is that virus, minority are caused by antibacterial, virus is mainly influenza virus, parainfluenza virus, respiratory syncytial virus etc., when running into, resistance reduces, overtired, the inducement such as suffer from cold, drench with rain, make to be present in upper respiratory tract or from the breeding and causing rapidly of the virus of intrusion or antibacterial, the disease that affection due to external wind and heat causes is flu, cough, pharyngolaryngitis, urinary tract infection etc.
The existing method that is used for the treatment of the disease that affection due to external wind and heat causes is a lot, often selects the herbaceous plant such as Flos Chrysanthemi, Herba Menthae, Folium Mori.Chinese patent medicine can be selected SANHUANG PIAN, antitoxic bolus of honeysuckle flower and forsythia (sheet), YINQIAO JIEDU PIAN+detoxicating tablet of cow-bezoar, Lingqiaojiedu pills, SUNJU GANMAO PIAN, Radix Isatidis electuary, SHUANGHUANGLIAN KOUFUYE (electuary) etc., and these medical instruments have antipyretic and antidote functions; But these Chinese medicine effects differ, specific aim is not strong, unsatisfactory curative effect, can only play the effect of auxiliary treatment.
Below all can only use as medicine, and can not can arbitrarily eat as the composite formula of Wang Laoji etc., but also not have on the market at present a kind ofly to be used for the treatment of medicine that disease effects that affection due to external wind and heat causes is good, to eat dual-purpose vegetable composition medicine.
Summary of the invention
The object of the invention is to provide a kind of medicine of clearing away lung-heat to relieve cough, and its good drug efficacy can be used as medicine, the food beverage is taken simultaneously, is particularly suitable as the herbal tea beverage and promotes and to take.
Another purpose of the present invention is to provide the preparation method of said medicine being made to oral drug preparation and oral beverage.
The object of the invention adopts following technical scheme to realize:
A kind of medicine of clearing away lung-heat to relieve cough is characterized in that: it is to be that crude drug is made by Folium Mori, Flos Chrysanthemi, Semen Armeniacae Amarum, Spica Prunellae, Herba Menthae, Radix Platycodonis, Radix Glycyrrhizae, Rhizoma Phragmitis and Herba Houttuyniae.
The present invention is through large quantity research, selection, in order to realize better drug effect, the preferred weight umber proportioning of above-mentioned nine kinds of raw materials is: Folium Mori 4-15 part, Flos Chrysanthemi 2-7 part, Semen Armeniacae Amarum 5-25 part, Spica Prunellae 3-18 part, Herba Menthae 1-4 part, Radix Platycodonis 5-25 part, Radix Glycyrrhizae 1-4 part, Rhizoma Phragmitis 5-25 part and Herba Houttuyniae 3-20 part.
Still more preferably, 11 parts of 6 parts, Folium Mori, 2.5 parts of Flos Chrysanthemis, 5 parts, Semen Armeniacae Amarum, 4 parts of Spica Prunellaes, 2 parts of Herba Menthaes, 5 parts of Radix Platycodoniss, 2 parts, Radix Glycyrrhizae, 5 parts of Rhizoma Phragmitiss and Herba Houttuyniae, in parts by weight.
Medicine of the present invention is prepared into to the production method of drug oral preparation:
A. the preparation of Semen Armeniacae Amarum distillate and Oleum menthae
After Semen Armeniacae Amarum squeezing degrease oil, use vapor distillation, collect distillate; Herba Menthae is extracted volatile oil.
B.(1) medicinal residues and the remaining raw medicinal material of above-mentioned A step gained Semen Armeniacae Amarum, Herba Menthae are prepared burden in proportion, decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filtered, and filtrate merges; (2) concentrated mix decocting liquid to the decocting liquid original volume 1/3 after be cooled to room temperature; Adding 95% ethanol again and regulating determining alcohol is that 70%(is in volumn concentration), standing 2 hours, filtration, collect filtrate, then add A step gained distillate, volatile oil to carry out concentrating under reduced pressure and obtain thick paste; (3) add conventional adjuvant in thick paste, then carry out the conventional post processing of oral preparation of Chinese traditional medicinal; As add appropriate dextrin and stevioside to mix, granulation agent according to a conventional method; It can certainly be made to tablet, oral liquid etc. according to a conventional method.
The present composition is prepared into to the method for oral beverage, below each raw material all in weight portion:
(1) distillation, extraction: after 5-25 part Semen Armeniacae Amarum squeezing degrease oil, use vapor distillation, collect distillate; Herba Menthae 1-4 part is extracted volatile oil.
(2) decoct: take Folium Mori 4-15 part, Flos Chrysanthemi 2-7 part, Spica Prunellae 3-18 part, Radix Platycodonis 5-25 part, Radix Glycyrrhizae 1-4 part, Rhizoma Phragmitis 5-25 part, Herba Houttuyniae 3-20 part, the decocting that adds first 10 times of weight of medical material boils 2 hours, obtains medicinal liquid A; Then add the decocting decoct medicinal herbs slag 1 hour of 8 times of weight of medical material, obtain medical liquid B, merge A, twice filtrate of B, with 200 eye mesh screens filtrations;
(3) allotment: the filtrate, and (1) step gained distillate and the volatile oil that 400～500 parts of purified water, 20～30 portions of white sugars or sugar alcohol, (2) step gained are decocted to medicinal liquid, fully mix and make the semi-finished product beverage liquid, described sugar alcohol is one or more in mannitol, sorbitol, inositol;
(4) filter: the semi-finished product beverage liquid prepared is filtered through 350 eye mesh screen duplex strainers;
(5) vacuum outgas: when during charging, the temperature of beverage liquid is than the beverage liquid vacuum outgas temperature high 3 ℃～5 ℃, beverage liquid is at 65～70 ℃, degassed under 76.3～70.2kPa vacuum condition;
(6) fill: use filling machine to be poured into, the sealing machine sealing;
(7) sterilizing, cooling: adopt horizontal sterilization kettle to carry out the high-temperature pressurizing steam sterilization, sterilising temp is 114～116 ℃, sterilization time is 20 minutes, and pressure is 0.1Mpa, after sterilizing finishes, make the sterilization kettle internal pressure be kept above sterilization pressure 0.02Mpa～0.028Mpa, open lentamente cooling valve and keep pressure stability, pass into compressed air or cooling water temperature, along with temperature descends, pressure reduces gradually, is cooled to 30 ℃;
(8) drying: use the air compressor machine drying after sterilizing, or towel off the pop can surface moisture, dry rear room temperature storage.
The present invention has following beneficial effect:
Nine kinds of raw material of Chinese medicine science compatibilities of the present invention have produced synergism, for anemopyretic cold, and lung heat clearing, the conjunctival congestion headache, cough, xerostomia, dizziness and tinnitus, laryngopharynx swelling and pain, the lung abscess vomiting pus, the expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, furuncle swelling toxin, the diseases such as acute pneumonia.In addition, nine kinds of medical materials of the present invention be integration of edible and medicinal herbs medical material, character gentle, can eat for a long time, have no side effect, the medicine food has both, and can be prepared into herbal tea, healthy beverage or make various pharmaceutical formulations, takes scope wide.Production technology of the present invention is simple, strong operability, high, the applicable suitability for industrialized production of product active constituent content.
The preparation method of the oral beverage of the present invention has been preserved the nutritional labeling in the beverage liquid well, and reaches the purpose of abundant sterilizing, and extends the shelf life, keeps taste flavor.The selection of the adjuvants such as its sweeting agent highlighted the natural mouthfeel of beverage liquid with the Chinese herbal medicine local flavor, also reduced sweet taste to the covering of natural taste flavor, but avoided well the bitter taste produced.
In order to further illustrate the drug effect of the present composition, for medical institutions, be below the clinical research experiment situation that the present invention does:
1, the present invention carries out clinical trial inpatient totally 425 examples, all by the case choice criteria, selects.The clinical trial random packet, carry out non-blind controlled trial, wherein treatment group 284 examples, matched group 141 examples, the course for the treatment of, the acute pharyngolaryngitis patient was 4 days, acute pneumonia patient 1 week, patients of urinary tract infection 5 weeks, anemopyretic cold patient 3 days, Therapeutic Method: oral liquid, every day 3 times, each 15ml(is equivalent to crude drug amount 7.2g/15ml); Granule, every day 3 times, each 1 bag (being equivalent to crude drug amount 7.2g/ bag); Capsule, every day 3 times, each 2-3 grain (being equivalent to crude drug amount 2.4g/ grain); Syrup, every day 3 times, each 10ml(is equivalent to crude drug amount 7.2g/10ml).According to the judgment criteria course for the treatment of, therapeutic outcome shows acute pharyngolaryngitis group 25 examples, and total effective rate and total obvious effective rate are respectively 98.7% and 98.3%; Acute pneumonia group 30 examples, total effective rate and total obvious effective rate are respectively 99% and 98.5%; Urinary tract infection group 23 examples, total effective rate and total obvious effective rate are respectively 96.0 % and 94.0%; Anemopyretic cold group 63 examples, total effective rate and total obvious effective rate are respectively 98.7% and 98.2%.All do not find untoward reaction and any toxic and side effects during the treatment of each disease, pharmaceutical composition safety of the present invention is good simultaneously.
Above experiment shows: medicine of the present invention is remarkable for the drug effect of acute pneumonia, lung heat clearing, cough, pharyngolaryngitis etc., also as clearing away lung-heat, sunstroke prevention etc.The medical material that simultaneously the present invention adopts is medicine-food two-purpose, has no side effect, and can be prepared into herbal tea, healthy beverage carries out wider popularization, fully develops drug effect of the present invention and is worth.
the specific embodiment
Below by embodiment, the present invention is specifically described; but following examples are only for being further detailed the present invention; can not be interpreted as the restriction to its protection domain, the person skilled in the art in this field can make some nonessential improvement and adjustment to the present invention according to foregoing.
embodiment 1
The preparation of oral preparation of Chinese traditional medicinal:
Take raw material (unit: kg) Folium Mori 6, Flos Chrysanthemi 2.5, Semen Armeniacae Amarum 5, Spica Prunellae 4, Herba Menthae 2, Radix Platycodonis 5, Radix Glycyrrhizae 2, Rhizoma Phragmitis 5 and Herba Houttuyniae 11;
A. the preparation of Semen Armeniacae Amarum distillate and Oleum menthae
After Semen Armeniacae Amarum squeezing degrease oil, use vapor distillation, collect distillate; Herba Menthae is extracted volatile oil.
B.(1) medicinal residues and the remaining medical material of above-mentioned A step gained Semen Armeniacae Amarum, Herba Menthae are prepared burden in proportion, decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filtered, and filtrate merges; (2) concentrated mix decocting liquid to the decocting liquid original volume 1/3 after be cooled to room temperature; Adding 95% ethanol again and regulating determining alcohol is that 70%(is in volumn concentration), standing 2 hours, filtration, collect filtrate, then add A step gained distillate, volatile oil to carry out concentrating under reduced pressure and obtain thick paste; (3) add conventional adjuvant in thick paste, then carry out the conventional post processing of oral preparation of Chinese traditional medicinal; As add appropriate dextrin and stevioside to mix, granulation agent according to a conventional method; It can certainly be made to tablet, oral liquid etc. according to a conventional method.
embodiment 2-5: prepare oral preparation of Chinese traditional medicinal by following proportioning raw materials, other techniques and embodiment 1 are same:
| Embodiment | Folium Mori | Flos Chrysanthemi | Semen Armeniacae Amarum | Spica Prunellae | Herba Menthae | Radix Platycodonis | Radix Glycyrrhizae | Rhizoma Phragmitis | Herba Houttuyniae |
| 2 | 8 | 5 | 10 | 15 | 3 | 25 | 4 | 7 | 15 |
| 3 | 4 | 2 | 5 | 18 | 2 | 21 | 2 | 5 | 20 |
| 4 | 10 | 6 | 18 | 8 | 1 | 10 | 1 | 25 | 9 |
| 5 | 15 | 7 | 25 | 3 | 4 | 5 | 3 | 18 | 3 |
embodiment 6
The preparation of oral beverage, below each raw material all in weight portion:
(1) distillation, extraction: after 5 parts of Semen Armeniacae Amarums squeezing degrease oil, use vapor distillation, collect distillate; 2 parts of extraction volatile oil of Herba Menthae.
(2) decoct: take 6 parts, Folium Mori, 2.5 parts of Flos Chrysanthemis, 4 parts of Spica Prunellaes, 5 parts of Radix Platycodoniss, 2 parts, Radix Glycyrrhizae, 5 parts of Rhizoma Phragmitiss, 11 parts of Herba Houttuyniae, the decocting that adds first 10 times of weight of medical material boils 2 hours, obtains medicinal liquid A; Then add the decocting decoct medicinal herbs slag 1 hour of 8 times of weight of medical material, obtain medical liquid B, merge A, twice filtrate of B, with 200 eye mesh screens filtrations;
(3) allotment: the filtrate, and (1) step gained distillate and the volatile oil that 400～500 parts of purified water, 20～30 portions of white sugars or sugar alcohol, (2) step gained are decocted to medicinal liquid, fully mix and make the semi-finished product beverage liquid, described sugar alcohol is one or more in mannitol, sorbitol, inositol;
(4) filter: the semi-finished product beverage liquid prepared is filtered through 350 eye mesh screen duplex strainers;
(5) vacuum outgas: when during charging, the temperature of beverage liquid is than the beverage liquid vacuum outgas temperature high 3 ℃～5 ℃, beverage liquid is at 65～70 ℃, degassed under 76.3～70.2kPa vacuum condition;
(6) fill: use filling machine to be poured into, the sealing machine sealing;
(7) sterilizing, cooling: adopt horizontal sterilization kettle to carry out the high-temperature pressurizing steam sterilization, sterilising temp is 114～116 ℃, sterilization time is 20 minutes, and pressure is 0.1Mpa, after sterilizing finishes, make the sterilization kettle internal pressure be kept above sterilization pressure 0.02Mpa～0.028Mpa, open lentamente cooling valve and keep pressure stability, pass into compressed air or cooling water temperature, along with temperature descends, pressure reduces gradually, is cooled to 30 ℃;
(8) drying: use the air compressor machine drying after sterilizing, or towel off the pop can surface moisture, dry rear room temperature storage.
embodiment 7-9: prepare oral beverage by following proportioning raw materials, other techniques and embodiment 6 are same:
| Embodiment | Folium Mori | Flos Chrysanthemi | Semen Armeniacae Amarum | Spica Prunellae | Herba Menthae | Radix Platycodonis | Radix Glycyrrhizae | Rhizoma Phragmitis | Herba Houttuyniae |
| 7 | 8 | 3 | 15 | 10.5 | 2.5 | 7 | 1.5 | 12 | 11 |
| 8 | 12 | 5 | 18 | 16 | 3.5 | 18 | 3 | 20 | 15 |
| 9 | 6 | 6 | 20 | 7 | 1.8 | 22 | 4 | 17 | 8 |
Claims (5)
1. the medicine of a clearing away lung-heat to relieve cough, it is characterized in that: it is to be that raw material is made by Folium Mori, Flos Chrysanthemi, Semen Armeniacae Amarum, Spica Prunellae, Herba Menthae, Radix Platycodonis, Radix Glycyrrhizae, Rhizoma Phragmitis and Herba Houttuyniae.
2. medicine as claimed in claim 1, it is characterized in that: it is to be that raw material is made by Folium Mori 4-15 part of parts by weight proportioning meter, Flos Chrysanthemi 2-7 part, Semen Armeniacae Amarum 5-25 part, Spica Prunellae 3-18 part, Herba Menthae 1-4 part, Radix Platycodonis 5-25 part, Radix Glycyrrhizae 1-4 part, Rhizoma Phragmitis 5-25 part and Herba Houttuyniae 3-20 part.
3. medicine as claimed in claim 1 is characterized in that: it is to be that raw material is made by 11 parts of 5 parts of 2 parts, 5 parts of 2 parts of 4 parts of 5 parts, 2.5 parts of 6 parts, Folium Mori, Flos Chrysanthemis, Semen Armeniacae Amarum, Spica Prunellaes, Herba Menthaes, Radix Platycodoniss, Radix Glycyrrhizae, the Rhizoma Phragmitiss of parts by weight proportioning meter and Herba Houttuyniae.
4. the described medicine of claim 1-3 any one is made to the method for oral formulations, be it is characterized in that, it carries out as follows:
A. the preparation of Semen Armeniacae Amarum distillate and Oleum menthae
After Semen Armeniacae Amarum squeezing degrease oil, use vapor distillation, collect distillate; Herba Menthae is extracted volatile oil;
B.(1) medicinal residues and the remaining medical material of above-mentioned A step gained Semen Armeniacae Amarum, Herba Menthae are prepared burden in proportion, decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filtered, and filtrate merges; (2) concentrated mix decocting liquid to the decocting liquid original volume 1/3 after be cooled to room temperature; Adding 95% ethanol again and regulating determining alcohol is that 70%(is in volumn concentration), standing 2 hours, filtration, collect filtrate, then add A step gained distillate, volatile oil to carry out concentrating under reduced pressure and obtain thick paste; (3) add conventional adjuvant in thick paste, then the drug oral preparation is made in the conventional post processing of carrying out oral preparation of Chinese traditional medicinal.
5. the described medicine of claim 1-3 any one is prepared into to the method for oral beverage, it is characterized in that, it carries out as follows, below each raw material all in weight portion:
(1) distillation, extraction: after Semen Armeniacae Amarum squeezing degrease oil, use vapor distillation, collect distillate; Herba Menthae is extracted volatile oil;
(2) decoct: take Folium Mori, Flos Chrysanthemi, Spica Prunellae, Radix Platycodonis, Radix Glycyrrhizae, Rhizoma Phragmitis, Herba Houttuyniae, the decocting that adds first 10 times of weight of medical material boils 2 hours, obtains medicinal liquid A; Then add the decocting decoct medicinal herbs slag 1 hour of 8 times of weight of medical material, obtain medical liquid B, merge A, twice filtrate of B, with 200 eye mesh screens filtrations;
(3) allotment: the filtrate, and (1) step gained distillate and the volatile oil that 400～500 parts of purified water, 20～30 portions of white sugars or sugar alcohol, (2) step gained are decocted to medicinal liquid, fully mix and make the semi-finished product beverage liquid, described sugar alcohol is one or more in mannitol, sorbitol, inositol;
(4) filter: the semi-finished product beverage liquid prepared is filtered through 350 eye mesh screen duplex strainers;
(5) vacuum outgas: when during charging, the temperature of beverage liquid is than the beverage liquid vacuum outgas temperature high 3 ℃～5 ℃, beverage liquid is at 65～70 ℃, degassed under 76.3～70.2kPa vacuum condition;
(6) fill: use filling machine to be poured into, the sealing machine sealing;
(7) sterilizing, cooling: adopt horizontal sterilization kettle to carry out the high-temperature pressurizing steam sterilization, sterilising temp is 114～116 ℃, sterilization time is 20 minutes, and pressure is 0.1Mpa, after sterilizing finishes, make the sterilization kettle internal pressure be kept above sterilization pressure 0.02Mpa～0.028Mpa, open lentamente cooling valve and keep pressure stability, pass into compressed air or cooling water temperature, along with temperature descends, pressure reduces gradually, is cooled to 30 ℃;
(8) drying: use the air compressor machine drying after sterilizing, or towel off the pop can surface moisture, dry rear room temperature storage.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104585428A (en) * | 2015-01-26 | 2015-05-06 | 吴燕 | Rose-folium mori-mint tea |
| CN104922525A (en) * | 2015-07-08 | 2015-09-23 | 闫花英 | Traditional Chinese medicine composition for treating pulmonary abscess |
| CN105146661A (en) * | 2015-09-22 | 2015-12-16 | 南陵县石斛产业协会 | Processing method of platycodon grandiflorum and folium mori health care beverage |
| CN106721691A (en) * | 2016-11-15 | 2017-05-31 | 王博 | A kind of gold bead sand pear strengthens the preparation method of cough-relieving drink |
| CN107998258A (en) * | 2018-01-31 | 2018-05-08 | 张冰 | A kind of Chinese medicine composition for improving interstitial pneumonia and preparation method thereof |
| CN109125560A (en) * | 2018-11-02 | 2019-01-04 | 广东逸丰生态实业有限公司 | A kind of dried orange peel buccal tablet and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103284266A (en) * | 2013-05-31 | 2013-09-11 | 周明刚 | Mulberry leaf and chrysanthemum beverage functional beverage and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103284266A (en) * | 2013-05-31 | 2013-09-11 | 周明刚 | Mulberry leaf and chrysanthemum beverage functional beverage and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104585428A (en) * | 2015-01-26 | 2015-05-06 | 吴燕 | Rose-folium mori-mint tea |
| CN104922525A (en) * | 2015-07-08 | 2015-09-23 | 闫花英 | Traditional Chinese medicine composition for treating pulmonary abscess |
| CN105146661A (en) * | 2015-09-22 | 2015-12-16 | 南陵县石斛产业协会 | Processing method of platycodon grandiflorum and folium mori health care beverage |
| CN106721691A (en) * | 2016-11-15 | 2017-05-31 | 王博 | A kind of gold bead sand pear strengthens the preparation method of cough-relieving drink |
| CN107998258A (en) * | 2018-01-31 | 2018-05-08 | 张冰 | A kind of Chinese medicine composition for improving interstitial pneumonia and preparation method thereof |
| CN109125560A (en) * | 2018-11-02 | 2019-01-04 | 广东逸丰生态实业有限公司 | A kind of dried orange peel buccal tablet and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN103463503B (en) | 2016-01-06 |
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