CN103520529A - Composition for preventing or treating diseases caused by exogenous wind heat and preparation method - Google Patents
Composition for preventing or treating diseases caused by exogenous wind heat and preparation method Download PDFInfo
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Abstract
The invention relates to composition for preventing or treating diseases caused by exogenous wind heat, and the composition is prepared from raw materials of folium mori, chrysanthemum, almond, prunella vulgaris, mint, platycodon grandiflorum, liquorice and reed rhizome. Eight traditional Chinese medicine raw materials in the composition generate a synergistic effect due to scientific compatibility; various medicines are combined for use and learn from each other; the composition has effect of removing wet potential, resolving sore toxin, dispelling wind, clearing away heat, diffusing the lung and suppressing coughing; all the traditional Chinese medicine raw materials take effects of clearing away heat, removing toxicity, relieving sore throat and suppressing coughing together; and the composition treats both symptoms and root causes. By clinical verifications, the composition can effectively reinforce immunocompetence of organisms, can effectively prevent and treat wind-heat cold, hot eye headache, hypertension, cough and furuncle pyogenic infections, relieves sore throat, prevents sunstroke and resists to urinary system infection. The composition disclosed by the invention has wide drug treatment disease spectrum, strong pertinence and obvious treatment effect; and moreover, the eight medicinal materials are all homologous medicinal materials, have mild performance, can be taken for a long time, can be prepared into herbal tea and healthy beverages or be made into various medicine preparations and have a wide taking range.
Description
Technical field
The present invention relates to a kind ofly for preventing or treat the vegetable composition of the disease that affection due to external wind and heat causes, belong to food and medicine technical field.
Background technology
Affection due to external wind and heat is due to evil criminal's table, the lung qi of wind heat become estranged, Symptoms for heating weight, micro evil wind, distending pain in the head, have that antiperspirant, red swelling and pain of throat, cough, expectorant are sticky or yellow, the yellow thick nasal discharge of having a stuffy nose, thirst and liking drink, the tip of the tongue limit are red, the micro-Huang of white and thin fur, method for the treatment of be take relieving the exterior syndrome with drugs of pungent in flavor and cool in nature as main.Affection due to external wind and heat belongs to a kind of disease of Chinese medicine, the upper respiratory tract infection that belongs to modern medicine, the common cause of disease is that virus, minority are caused by antibacterial, virus is mainly influenza virus, parainfluenza virus, respiratory syncytial virus etc., when running into, resistance reduces, overtired, the inducement such as suffer from cold, drench with rain, make to be present in upper respiratory tract or breed rapidly and cause from virus or the antibacterial of outer intrusion, the disease that affection due to external wind and heat causes is flu, cough, pharyngolaryngitis, urinary tract infection etc.
The existing method that is used for the treatment of the disease that affection due to external wind and heat causes is a lot, often selects the herbaceous plant such as Flos Chrysanthemi, Herba Menthae, Folium Mori.Chinese patent medicine can be selected SANHUANG PIAN, antitoxic bolus of honeysuckle flower and forsythia (sheet), YINQIAO JIEDU PIAN+detoxicating tablet of cow-bezoar, Lingqiaojiedu pills, SUNJU GANMAO PIAN, Radix Isatidis electuary, SHUANGHUANGLIAN KOUFUYE (electuary) etc., and these medical instruments have antipyretic and antidote functions; But these Chinese medicine effects differ, specific aim is not strong, unsatisfactory curative effect, can only play the effect of auxiliary treatment.
Below all can only use as medicine, and can not can arbitrarily eat as the composite formula of Wang Laoji etc., also do not have on the market at present a kind of be used for the treatment of disease effects that affection due to external wind and heat causes good can medicine, eat dual-purpose vegetable composition medicine.
Summary of the invention
It is a kind of for preventing or treat the composition medicine of affection due to external wind and heat disease that the object of the invention is to provide, and its good drug efficacy can be used as medicine, food beverage is taken simultaneously, is particularly suitable as herbal tea beverage and promotes and to take.
Another object of the present invention is to provide the preparation method of above-mentioned composition medicine being made to oral drug preparation and oral beverage.
The object of the invention adopts following technical scheme to realize:
For preventing or treat a compositions for affection due to external wind and heat disease, it is characterized in that: it is comprised of Folium Mori, Flos Chrysanthemi, Semen Armeniacae Amarum, Spica Prunellae, Herba Menthae, Radix Platycodonis, Radix Glycyrrhizae and Rhizoma Phragmitis.
Folium Mori have dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, the effect of cooling blood for hemostasis.Cure mainly anemopyretic cold or pathogenic wind-warm from the beginning of, fever and headache, perspiration and aversion to wind, cough chest pain; Or dryness of the lung dry cough without phlegm; Dry throat and mouth; On wind heat and liver-yang, disturb; Conjunctival congestion and swelling pain.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
The heat clearing away of chrysanthemum powder forimproving wind, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.There are calmness, refrigeration function.Staphylococcus aureus, group B streptococcus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, bacillus pyocyaneus, mycobacterium hominis and influenza virus are all had to inhibitory action.Flos Chrysanthemi dispelling wind a little less than, heat clearing away power is good, Flos Chrysanthemi is controlled conjunctival congestion and swelling pain, no matter belongs to liver-fire or wind heat causer, all can apply, because this product can clearing away liver-fire, the wind heat of faling apart again.The merit of Flos Chrysanthemi heat-clearing and toxic substances removing is excellent, is surgery key medicine, is mainly used in the disease of pathopyretic ulcer, red and swollen heat pain, especially has good efficacy especially for the furuncle poison that swells and ache, and both oral administration, can mash external application again.Flos Chrysanthemi energy pancake liver-yang, the vertigo that excessive rising of liver-YANG is caused, often with the application of the compatibility such as Concha Margaritifera, Pueraria lobata.
Semen Armeniacae Amarum blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.Antitussive, antiasthmatic effect: in Semen Armeniacae Amarum, contain amygdaloside, amygdaloside can be hydrolyzed by enteric microorganism enzyme or the contained emulsin of Semen Armeniacae Amarum itself in vivo, produce micro-hydrocyanic acid and benzaldehyde, respiratory center is had to inhibitory action, reach antitussive, antiasthmatic effect.
Spica Prunellae has the effect of letting out clearly liver-fire, mass dissipating and swelling eliminating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, cooling blood for hemostasis, is applicable to lymphoid tuberculosis, goiter, acute mastitis, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, Fiedeler's disease type hepatitis and bacillary dysentery etc.Modern pharmacological research shows, Spica Prunellae has the effect reducing blood pressure, and can blood vessel dilating, and its contained rutin has antiinflammatory action, and can reduce vascular permeability, reduces fragility, reduces liver fat.
Herba Menthae has wind-dispelling heat-dissipating, refresh oneself, throat, rash, the effect of resolving depression.Cure mainly wind heat table disease, have a headache dizzy, conjunctival congestion and swelling pain, pharyngalgia celostomia, nasal sinusitis, toothache, measles without adequate eruption, urticaria pruritus, hypochondriac pain due to stagnation of liverQI gastral cavity is swollen, scrofula tuberculosis.
Radix Platycodonis is opened lung qi dispersing gas, the evacuation of pus of eliminating the phlegm.Control exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache.
Radix Glycyrrhizae has removing toxic substances, eliminates the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer.In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency removing toxic substances, is in harmonious proportion hundred medicines.Treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time.Raw by pathogenic fire purging heat, the ripe use exterior cold of fall apart, goes pharyngalgia, except pathogenic heat, delays healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening.The also Chang Peiwu application of cough due to pathogenic wind-heat, cough due to wind and cold, phlegm heat cough.
Rhizoma Phragmitis has clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, the effect of diuresis.Be applicable to calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.
The present invention is through large quantity research, selection, in order to realize better drug effect, the preferred weight umber proportioning of above-mentioned eight kinds of raw materials is: Folium Mori 10-100 part, Flos Chrysanthemi 5-40 part, Semen Armeniacae Amarum 10-80 part, Spica Prunellae 50-160 part, Herba Menthae 4-35 part, Radix Platycodonis 10-80 part, Radix Glycyrrhizae 5-38 part, Rhizoma Phragmitis 10-80 part.
Still more preferably, 50 parts, Folium Mori, 20 parts of Flos Chrysanthemis, 40 parts, Semen Armeniacae Amarum, 130 parts of Spica Prunellaes, 16 parts of Herba Menthaes, 40 parts of Radix Platycodoniss, 16 parts, Radix Glycyrrhizae, 40 parts of Rhizoma Phragmitiss, in parts by weight.
Medicine of the present invention is prepared into the production method of drug oral preparation:
A. the preparation of Semen Armeniacae Amarum distillate and Oleum menthae
After Semen Armeniacae Amarum squeezing degrease oil, with vapor distillation, collect distillate; Herba Menthae is extracted volatile oil.
B.(1) medicinal residues and the remaining medical material of above-mentioned A step gained Semen Armeniacae Amarum, Herba Menthae are prepared burden in proportion, decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filtered, and filtrate merges; (2) concentrated mix decocting liquid to decocting liquid original volume 1/3 after be cooled to room temperature; Adding 95% ethanol again and regulating determining alcohol is that 70%(is in volumn concentration), standing 2 hours, filtration, collect filtrate, then add A step gained distillate, volatile oil to carry out concentrating under reduced pressure and obtain thick paste; (3) in thick paste, add conventional adjuvant, then carry out the conventional post processing of oral preparation of Chinese traditional medicinal; As add appropriate dextrin and stevioside to mix, granulation agent according to a conventional method; It can certainly be made to tablet, oral liquid etc. according to a conventional method.
The present composition is prepared into the method for oral beverage, following raw material is all in weight portion:
(1) distillation, extraction: after 10-80 part Semen Armeniacae Amarum squeezing degrease oil, with vapor distillation, collect distillate; Herba Menthae 4-35 part is extracted volatile oil.
(2) decoct: take Folium Mori 10-100 part, Flos Chrysanthemi 5-40 part, Spica Prunellae 50-160 part, Radix Platycodonis 10-80 part, Radix Glycyrrhizae 5-38 part, Rhizoma Phragmitis 10-80 part, the decocting that adds first 10 times of weight of medical material boils 2 hours, obtains medicinal liquid A; Then the decocting decoct medicinal herbs slag 1 hour that adds 8 times of weight of medical material, obtains medical liquid B, merges A, twice filtrate of B, with 200 eye mesh screens filtrations;
(3) allotment: the filtrate and (1) step gained distillate and the volatile oil that 1900～2860 parts of purified water, 153～230 portions of white sugars or sugar alcohol, (2) step gained are decocted to medicinal liquid, fully mix and make semi-finished product beverage liquid, described sugar alcohol is one or more in mannitol, sorbitol, inositol;
(4) filter: the semi-finished product beverage liquid preparing is filtered through 350 eye mesh screen duplex strainers;
(5) vacuum outgas: when during charging, the temperature of beverage liquid is than beverage liquid vacuum outgas temperature high 3 ℃～5 ℃, beverage liquid is at 65～70 ℃, degassed under 76.3～70.2kPa vacuum condition;
(6) fill: use filling machine to pour into, sealing machine sealing;
(7) sterilizing, cooling: adopt horizontal sterilization kettle to carry out high-temperature pressurizing steam sterilization, sterilising temp is 114～116 ℃, sterilization time is 20 minutes, and pressure is 0.1Mpa, after sterilizing finishes, make sterilization kettle internal pressure be kept above sterilization pressure 0.02Mpa～0.028Mpa, open lentamente cooling valve and keep pressure stability, pass into compressed air or cooling water temperature, along with temperature declines, pressure reduces gradually, is cooled to 30 ℃;
(8) dry: dry with air compressor machine after sterilizing, or towel off pop can surface moisture, dry rear room temperature storage.
The present invention has following beneficial effect:
Eight kinds of raw material of Chinese medicine science compatibilities of the present invention have produced synergism, and all medicines share, learn from other's strong points to offset one's weaknesses, except arthralgia chiefly caused by damp pathogen, solution sore, wind-dispelling heat-dissipating, lung qi dispersing cough-relieving, the effect that full side plays heat-clearing and toxic substances removing, smooth throat to stop cough altogether, treating both the exterior and interior.Pharmaceutical composition of the present invention is through clinical verification, the effective immunocompetence of enhancing body, can effectively prevent and treat anemopyretic cold, conjunctival congestion headache, hypertension, cough-relieving, furuncle swelling toxin, sore-throat relieving, sunstroke prevention and anti-urinary system infection, the sick spectrum width of present composition Drug therapy, with strong points, therapeutic effect is remarkable; In addition, eight kinds of medical materials of the present invention be integration of edible and medicinal herbs medical material, character gentle, can eat for a long time, have no side effect, medicine food has both, and can be prepared into herbal tea, healthy beverage or make various pharmaceutical formulations, takes scope wide.Production technology of the present invention is simple, strong operability, high, the applicable suitability for industrialized production of product active constituent content.
The preparation method of the oral beverage of the present invention has been preserved the nutritional labeling in beverage liquid well, and reaches the object of abundant sterilizing, and extends the shelf life, keeps taste flavor.The selection of the adjuvants such as its sweeting agent highlighted the natural mouthfeel of beverage liquid with Chinese herbal medicine local flavor, also reduced sweet taste to the covering of natural taste flavor, but avoided well the bitter taste producing.
In order to further illustrate the drug effect of the present composition, below for medical institutions are the clinical research experiment situation that the present invention does:
1, the present invention carries out clinical trial inpatient totally 387 examples, all by case selection Standard Selection.Clinical trial random packet, carries out non-blind controlled trial, wherein treatment group 253 examples, matched group 134 examples, the course for the treatment of, acute pharyngolaryngitis patient was 4 days, patients of urinary tract infection 5 weeks, anemopyretic cold patient 3 days, Therapeutic Method: oral liquid, every day 3 times, each 15ml(is equivalent to crude drug amount 7.2g/15ml); Granule, every day 3 times, each 1 bag (being equivalent to crude drug amount 7.2g/ bag); Capsule, every day 3 times, each 2-3 grain (being equivalent to crude drug amount 2.4g/ grain); Syrup, every day 3 times, each 10ml(is equivalent to crude drug amount 7.2g/10ml).According to the judgment criteria course for the treatment of, therapeutic outcome shows acute pharyngolaryngitis group 25 examples, and total effective rate and total obvious effective rate are respectively 99% and 98.5%; Urinary tract infection group 23 examples, total effective rate and total obvious effective rate are respectively 96.3% and 94.5%; Anemopyretic cold group 86 examples, total effective rate and total obvious effective rate are respectively 98.5% and 98%.During the treatment of each disease, all do not find untoward reaction and any toxic and side effects, pharmaceutical composition safety of the present invention is good simultaneously.
More than experiment shows: the disease that the present composition causes as prevention, treatment affection due to external wind and heat is as remarkable in the drug effect of anemopyretic cold, cough, pharyngolaryngitis, urinary tract infection, also as heat clearing away, sunstroke prevention etc.The medical material that simultaneously the present invention adopts is medicine-food two-purpose, has no side effect, and can be prepared into herbal tea, healthy beverage carries out wider popularization, fully develops drug effect of the present invention and is worth.
the specific embodiment
Below by embodiment, the present invention is specifically described; but following examples are only for being further detailed the present invention; can not be interpreted as the restriction to its protection domain, the person skilled in the art in this field can make some nonessential improvement and adjustment to the present invention according to foregoing.
embodiment 1
The preparation of oral preparation of Chinese traditional medicinal:
Take raw material (unit: g) Folium Mori 50, Flos Chrysanthemi 20, Semen Armeniacae Amarum 40, Spica Prunellae 130, Herba Menthae 16, Radix Platycodonis 40, Radix Glycyrrhizae 16 and Rhizoma Phragmitis 40;
A. the preparation of Semen Armeniacae Amarum distillate and Oleum menthae
After Semen Armeniacae Amarum squeezing degrease oil, with vapor distillation, collect distillate; Herba Menthae is extracted volatile oil.
B.(1) medicinal residues and the remaining medical material of above-mentioned A step gained Semen Armeniacae Amarum, Herba Menthae are prepared burden in proportion, decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filtered, and filtrate merges; (2) concentrated mix decocting liquid to decocting liquid original volume 1/3 after be cooled to room temperature; Adding 95% ethanol again and regulating determining alcohol is that 70%(is in volumn concentration), standing 2 hours, filtration, collect filtrate, then add A step gained distillate, volatile oil to carry out concentrating under reduced pressure and obtain thick paste; (3) in thick paste, add conventional adjuvant, then carry out the conventional post processing of oral preparation of Chinese traditional medicinal; As add appropriate dextrin and stevioside to mix, granulation agent according to a conventional method; It can certainly be made to tablet, oral liquid etc. according to a conventional method.
embodiment 2-6: by following proportioning raw materials, prepare oral preparation of Chinese traditional medicinal, other techniques and embodiment 1 are same:
| Embodiment | Folium Mori | Flos Chrysanthemi | Semen Armeniacae Amarum | Spica Prunellae | Herba Menthae | Radix Platycodonis | Radix Glycyrrhizae | Rhizoma Phragmitis |
| 2 | 10 | 33 | 72 | 160 | 27 | 27 | 26 | 80 |
| 3 | 48 | 40 | 80 | 107 | 35 | 10 | 13 | 71 |
| 4 | 82 | 26 | 43 | 50 | 14 | 48 | 5 | 45 |
| 5 | 100 | 12 | 21 | 71 | 9 | 73 | 22 | 10 |
| 6 | 65 | 5 | 10 | 125 | 5 | 80 | 38 | 25 |
embodiment 7
The preparation of oral beverage, following raw material is all in weight portion:
(1) distillation, extraction: after 40 parts of Semen Armeniacae Amarums squeezing degrease oil, with vapor distillation, collect distillate; 16 parts of extraction volatile oil of Herba Menthae.
(2) decoct: take 50 parts, Folium Mori, 20 parts of Flos Chrysanthemis, 130 parts of Spica Prunellaes, 40 parts of Radix Platycodoniss, 16 parts, Radix Glycyrrhizae, 40 parts of Rhizoma Phragmitiss, the decocting that adds first 10 times of weight of medical material boils 2 hours, obtains medicinal liquid A; Then the decocting decoct medicinal herbs slag 1 hour that adds 8 times of weight of medical material, obtains medical liquid B, merges A, twice filtrate of B, with 200 eye mesh screens filtrations;
(3) allotment: the filtrate that 1900～2860 parts of purified water, 153～230 portions of white sugars or sugar alcohol, (2) step gained are decocted to medicinal liquid, and (1) step gained distillate and volatile oil, fully mix and make semi-finished product beverage liquid, described sugar alcohol is one or more in mannitol, sorbitol, inositol;
(4) filter: the semi-finished product beverage liquid preparing is filtered through 350 eye mesh screen duplex strainers;
(5) vacuum outgas: when during charging, the temperature of beverage liquid is than beverage liquid vacuum outgas temperature high 3 ℃～5 ℃, beverage liquid is at 65～70 ℃, degassed under 76.3～70.2kPa vacuum condition;
(6) fill: use filling machine to pour into, sealing machine sealing;
(7) sterilizing, cooling: adopt horizontal sterilization kettle to carry out high-temperature pressurizing steam sterilization, sterilising temp is 114～116 ℃, sterilization time is 20 minutes, and pressure is 0.1Mpa, after sterilizing finishes, make sterilization kettle internal pressure be kept above sterilization pressure 0.02Mpa～0.028Mpa, open lentamente cooling valve and keep pressure stability, pass into compressed air or cooling water temperature, along with temperature declines, pressure reduces gradually, is cooled to 30 ℃;
(8) dry: dry with air compressor machine after sterilizing, or towel off pop can surface moisture, dry rear room temperature storage.
embodiment 8-11: by following proportioning raw materials, prepare oral beverage, other techniques and embodiment 7 are same:
| Embodiment | Folium Mori | Flos Chrysanthemi | Semen Armeniacae Amarum | Spica Prunellae | Herba Menthae | Radix Platycodonis | Radix Glycyrrhizae | Rhizoma Phragmitis |
| 8 | 33 | 21 | 50 | 150 | 11 | 27 | 7 | 20 |
| 9 | 46 | 15 | 45 | 132 | 22 | 10 | 16 | 50 |
| 10 | 58 | 32 | 30 | 100 | 30 | 48 | 23 | 45 |
| 11 | 73 | 25 | 18 | 65 | 8 | 73 | 35 | 66 |
Claims (5)
1. for preventing or treat a compositions for affection due to external wind and heat disease, it is characterized in that: it is to be that raw material is made by Folium Mori, Flos Chrysanthemi, Semen Armeniacae Amarum, Spica Prunellae, Herba Menthae, Radix Platycodonis, Radix Glycyrrhizae and Rhizoma Phragmitis.
2. compositions as claimed in claim 1, is characterized in that: it is to be that raw material is made by Folium Mori 10-100 part of parts by weight proportioning meter, Flos Chrysanthemi 5-40 part, Semen Armeniacae Amarum 10-80 part, Spica Prunellae 50-160 part, Herba Menthae 4-35 part, Radix Platycodonis 10-80 part, Radix Glycyrrhizae 5-38 part and Rhizoma Phragmitis 10-80 part.
3. compositions as claimed in claim 1, is characterized in that: it is to be that raw material is made by 40 parts of 16 parts, 40 parts of 16 parts of 130 parts of 40 parts, 20 parts of 50 parts, Folium Mori, Flos Chrysanthemis, Semen Armeniacae Amarum, Spica Prunellaes, Herba Menthaes, Radix Platycodoniss, the Radix Glycyrrhizae of parts by weight proportioning meter and Rhizoma Phragmitiss.
4. compositions described in claim 1-3 any one is prepared into the method for drug oral preparation, it is characterized in that, it carries out as follows:
A. the preparation of Semen Armeniacae Amarum distillate and Oleum menthae
After Semen Armeniacae Amarum squeezing degrease oil, with vapor distillation, collect distillate; Herba Menthae is extracted volatile oil;
B.(1) medicinal residues and the remaining medical material of above-mentioned A step gained Semen Armeniacae Amarum, Herba Menthae are prepared burden in proportion, decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, decocting liquid filtered, and filtrate merges; (2) concentrated mix decocting liquid to decocting liquid original volume 1/3 after be cooled to room temperature; Adding 95% ethanol again and regulating determining alcohol is that 70%(is in volumn concentration), standing 2 hours, filtration, collect filtrate, then add A step gained distillate, volatile oil to carry out concentrating under reduced pressure and obtain thick paste; (3) in thick paste, add conventional adjuvant, then drug oral preparation is made in the conventional post processing of carrying out oral preparation of Chinese traditional medicinal.
5. compositions described in claim 1-3 any one is prepared into the method for oral beverage, it is characterized in that, it carries out as follows, and following raw material is all in weight portion:
(1) distillation, extraction: after Semen Armeniacae Amarum squeezing degrease oil, with vapor distillation, collect distillate; Herba Menthae is extracted volatile oil;
(2) decoct: take Folium Mori, Flos Chrysanthemi, Spica Prunellae, Radix Platycodonis, Radix Glycyrrhizae, Rhizoma Phragmitis, the decocting that adds first 10 times of weight of medical material boils 2 hours, obtains medicinal liquid A; Then the decocting decoct medicinal herbs slag 1 hour that adds 8 times of weight of medical material, obtains medical liquid B, merges A, twice filtrate of B, with 200 eye mesh screens filtrations;
(3) allotment: the filtrate and (1) step gained distillate and the volatile oil that 1900～2860 parts of purified water, 153～230 portions of white sugars or sugar alcohol, (2) step gained are decocted to medicinal liquid, fully mix and make semi-finished product beverage liquid, described sugar alcohol is one or more in mannitol, sorbitol, inositol;
(4) filter: the semi-finished product beverage liquid preparing is filtered through 350 eye mesh screen duplex strainers;
(5) vacuum outgas: when during charging, the temperature of beverage liquid is than beverage liquid vacuum outgas temperature high 3 ℃～5 ℃, beverage liquid is at 65～70 ℃, degassed under 76.3～70.2kPa vacuum condition;
(6) fill: use filling machine to pour into, sealing machine sealing;
(7) sterilizing, cooling: adopt horizontal sterilization kettle to carry out high-temperature pressurizing steam sterilization, sterilising temp is 114～116 ℃, sterilization time is 20 minutes, and pressure is 0.1Mpa, after sterilizing finishes, make sterilization kettle internal pressure be kept above sterilization pressure 0.02Mpa～0.028Mpa, open lentamente cooling valve and keep pressure stability, pass into compressed air or cooling water temperature, along with temperature declines, pressure reduces gradually, is cooled to 30 ℃;
(8) dry: dry with air compressor machine after sterilizing, or towel off pop can surface moisture, dry rear room temperature storage.
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| CN104906418A (en) * | 2015-06-12 | 2015-09-16 | 北京康舟润发高科技有限公司 | Medicine composition with anti-allergic effect |
| CN108465061A (en) * | 2018-06-01 | 2018-08-31 | 四川省中医药科学院 | It is a kind of to be used to treat pharmaceutical composition of Facial Recurrent Dermatitis and its preparation method and application |
| CN108465061B (en) * | 2018-06-01 | 2021-03-30 | 四川省中医药科学院 | Pharmaceutical composition for treating recurrent facial dermatitis and preparation method and application thereof |
| CN111569011A (en) * | 2020-05-14 | 2020-08-25 | 贵州神奇药物研究院 | New application of traditional Chinese medicine composition and preparation method thereof |
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