CN103735894A - Pharynx-clearing throat-refreshing lozenges and preparation method thereof - Google Patents
Pharynx-clearing throat-refreshing lozenges and preparation method thereof Download PDFInfo
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- CN103735894A CN103735894A CN201310715424.1A CN201310715424A CN103735894A CN 103735894 A CN103735894 A CN 103735894A CN 201310715424 A CN201310715424 A CN 201310715424A CN 103735894 A CN103735894 A CN 103735894A
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Abstract
The invention discloses pharynx-clearing throat-refreshing lozenges and a preparation method thereof. The pharynx-clearing throat-refreshing lozenges are prepared by extracting and refining the medicines of scaphium scaphigerum, chrysanthemum, platycodon grandiflorum, lophatherum gracile and the like, have good functions of clearing heat and refreshing pharynx, can be used for the patients with throat swelling and pain, dry throat, hoarseness, even aphonia, dry cough with little phlegm, dysphagia, and foreign body sensation in the throat, have good taste, are low in cost and are favorable to be selected and used by customers.
Description
Technical field
The invention belongs to medicine, field of health care food, relate to a kind of pharynx-clearing throat-benefiting buccal tablet and preparation method thereof.
Background technology
Acute and chronic pharyngitis, acute and chronic tonsillitis, stomatitis, flu cause laryngopharynx swelling and pain, thirsty and dry pharynx, even hoarseness aphonia, itching throat, the few expectorant of dry cough, dysphagia, bottleneck throat have the symptoms such as foreign body sensation, comparatively common in daily life, to people, bring very large worries and mental pressure, impact is worked normally, studying and living.Modern medicine shows: virus, antibacterial, outside stimulus (air pollution, air humidity are low, smoking, drink etc.) are can bottleneck throat uncomfortable.Doctor trained in Western medicine is generally alleviated with tabellae iodi gurgitis etc. pharyngeal discomfort, compared with refractory, heals.The traditional Chinese medical science thinks that throat illness is relevant with visceral dysfunction, and wind-heat invading the lung, dysfunction of the spleen in transportation, insufficiency of stomach-QI are weak etc. all can cause, and prevents and treats available heat-clearing and toxic substances removing, the main method of activating QI to eliminate phlegm, and Chinese medicine antagonism virus and antibacterial infection all have good therapeutic effect.In treatment, Chinese medicine demonstrates sizable advantage, if give full play to the advantage of Chinese medicine, develops the moistening and cleaning throat product of better efficacy, the society that will obtain and economic benefit.
The consumer objects of cleaning throat and moistening larynx product is generally patients with chronic pharyngitis, and these patients exist the symptoms such as throat is itched, twinge, dry cough more, and not too suitable with the treatment of capsule, peroral tablets, therapeutic effect is bad; Edible tea or other beverage regulate, prevent throat discomfort effect also good to inside of human body, but action time is short; And buccal tablet can for a long time, directly act on affected part, effect is relatively good, and the advantages such as buccal tablet also helps and carries, instant edible, therefore, current existing product is in the majority with buccal tablet, many experts think that buccal tablet from now on will be the wet one's whistle main flow dosage form of product of pharynx-clearing throat-benefiting, can also develop more new varieties and meet market demand.
Summary of the invention
The technical problem to be solved in the present invention is to provide that a kind of mouthfeel is good, cost is low, has the pharynx-clearing throat-benefiting buccal tablet of good heat clearing away, sore-throat relieving function.
Another technical problem that the present invention will solve is to provide the preparation method of this pharynx-clearing throat-benefiting buccal tablet.
For solving the problems of the technologies described above, the present invention is achieved by the following technical solutions:
A pharynx-clearing throat-benefiting buccal tablet, is made by the crude drug of following weight portion: Semen Sterculiae Lychnophorae 1-20 part, Flos Chrysanthemi 1-20 part, Radix Platycodonis 1-10 part, Herba Lophatheri 1-10 part.
Above-described pharynx-clearing throat-benefiting buccal tablet, is preferably made by the crude drug of following weight portion: Semen Sterculiae Lychnophorae 7-12 part, Flos Chrysanthemi 7-12 part, Radix Platycodonis 2-6 part, Herba Lophatheri 2-6 part.
Above-described relieving sore-throat by clearing away heat buccal tablet, the best is preferably made by the crude drug of following weight portion: 9 parts of Semen Sterculiae Lychnophoraes, 9 parts of Flos Chrysanthemis, 4 parts of Radix Platycodoniss, 4 parts of Herba Lophatheris.
The preparation method of above-mentioned pharynx-clearing throat-benefiting buccal tablet, comprises the steps:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, decocts with water 2-4 time, filter, and merging filtrate, concentrated, obtain extractum A;
B. get excipient, defoamer is added to the water heating for dissolving, obtains solution B;
C. get coolant agent organic solvent dissolution, obtain solution C;
D. extractum A and solution B are mixed, filter, vacuum boils, and makes most of moisture evaporation, adds solution C to stir, and makes tablet.
Described excipient can be white sugar, high maltose syrup, glucose syrup, hydroxyl isomaltulose etc., preferably one or both in white sugar and high maltose syrup.
Described defoamer for eliminating harmful foam that production process produces, is enhanced productivity, edible defoamer all can, preferred one or both in cocoa butter substitute and phospholipid.
Described coolant agent refers to the material that can produce cooling effect, as: menthol, Oleum menthae, MGA, Natural menthol, eucalyptus oil, asia peppermint vegetable oil etc., preferably one or more combinations in Natural menthol, eucalyptus oil and asia peppermint vegetable oil.
Described organic solvent is the material that can dissolve coolant agent, preferred alcohol, best preferably 85%～99% ethanol.
The consumption of above-mentioned excipient, defoamer, coolant agent, organic solvent is the conventional amount used of this technical field.
Each crude drug of pharynx-clearing throat-benefiting buccal tablet of the present invention, Semen Sterculiae Lychnophorae clearing heat and moistening lung, relieving sore throat to recover voice; Flos Chrysanthemi heat-clearing and toxic substances removing; Radix Platycodonis expelling phlegm for arresting cough; Herba Lophatheri clearing away heat-fire, expectorant are quenched the thirst.All medicine phases 5 have the effect of pharynx-clearing throat-benefiting, its scientific formulation, reasonable.Effective ingredient in pharynx-clearing throat-benefiting buccal tablet of the present invention acts on bottleneck throat lentamente by sucking, and reaches good pharynx-clearing throat-benefiting effect.This pharynx-clearing throat-benefiting buccal tablet mouthfeel is good, and production cost is low, and product stability is good, is suitable for producing in enormous quantities.
By reading description and appending claims below, can understand better these and other feature, aspect and advantage of the present invention.
The specific embodiment
Although this description by particularly pointing out and knowing that claimed claims of the present invention draw a conclusion, should be believed following explanation and will understand better the present invention.
The percentage ratio of ethanol as herein described is volume ratio.Except as otherwise noted, the equal actual content based on this composition of all percentage ratios, ratio and the content of related composition herein, and be not included in solvent, filler or other material that can combine with these compositions in commercially available prod.
As used herein, word " preferably " and variant refer to embodiment of the present invention that specific beneficial effect can be provided under specific environment.Yet other embodiment can be also preferred under identical or other environment.In addition, the detailed description of one or more preferred embodiments does not represent that other embodiment is useless, and is not intended to get rid of from category of the present invention other embodiment.
raw material
Semen Sterculiae Lychnophorae, is the dry mature seed of Sterculiaceae plant Semen Sterculiae Lychnophorae Sterculia lychnophora Hance, belongs to the integration of edible and medicinal herbs material of China's Ministry of Public Health regulation.Its sweet in the mouth, cold in nature, one of < < Chinese Pharmacopoeia > > version in 2010 carry " clearing heat and moistening lung, relieving sore throat to recover voice ....For lung-heat celostomia, dry cough without phlegm, pharyngodynia with dryness ... ".
Flos Chrysanthemi, is the dry capitulum of feverfew Chrysanthemum morifolium Ramat., belongs to the integration of edible and medicinal herbs material of China's Ministry of Public Health regulation.Its sweet in the mouth, hardship, cold nature, < < Chinese Pharmacopoeia > > one of version in 2010 is carried " loose wind heat clearing away, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing ".Flos Chrysanthemi has calmness, refrigeration function, and it all has inhibitory action to staphylococcus aureus, group B streptococcus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, bacillus pyocyaneus, mycobacterium hominis and influenza virus.
Radix Platycodonis, is the dry root of Campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.DC., belongs to the integration of edible and medicinal herbs material of China's Ministry of Public Health regulation.Its bitter in the mouth, pungent, property is flat, and within one year, " lung qi dispersing, sore-throat relieving eliminate the phlegm < < Chinese Pharmacopoeia > > version in 2010, evacuation of pus.For cough with copious phlegm ... pharyngalgia hoarseness ... ".Radix Platycodonis is eliminating phlegm and stopping cough good medicine since ancient times, < < Mingyi Bielu > > " controls laryngopharynx pain ", and < < book on Chinese herbal medicine covers bamboo fish trap > > and " by lung-heat, firmly coughs lower expectorant ".
Herba Lophatheri, is the dry stem and leaf of grass Herba Lophatheri Lophatherum gracile Brongn., belongs to the integration of edible and medicinal herbs material of China's Ministry of Public Health regulation.Its sweet in the mouth, light, cold in nature, < < Chinese Pharmacopoeia > > one of version in 2010 is carried " clearing away heat-fire, relieving restlessness is quenched the thirst ... ", < < detailed outline > >: go dysphoria with smothery sensation, the < < SHENGCAO property of medicine is standby wants > >: expectorant is quenched the thirst, < < book on Chinese herbal medicine is new > > again: clearing away heart-fire.
prescription
Pharynx-clearing throat-benefiting buccal tablet of the present invention, is made by the crude drug of following weight portion: Semen Sterculiae Lychnophorae 1-20 part, Flos Chrysanthemi 1-20 part, Radix Platycodonis 1-10 part, Herba Lophatheri 1-10 part.
In order to send better beneficial effect, the balance between " pharynx-clearing throat-benefiting curative effect " and " production cost ", is preferably made by the crude drug of following weight portion: Semen Sterculiae Lychnophorae 7-12 part, Flos Chrysanthemi 7-12 part, Radix Platycodonis 2-6 part, Herba Lophatheri 2-6 part.More preferably by the crude drug of following weight portion, made: 9 parts of Semen Sterculiae Lychnophoraes, 9 parts of Flos Chrysanthemis, 4 parts of Radix Platycodoniss, 4 parts of Herba Lophatheris.
adjuvant
The present invention can add suitable adjuvant so that this product molding, have certain mouthfeel and outward appearance etc.
Excipient can be: one or more of white sugar, high maltose syrup etc.
Defoamer can be: one or more of cocoa butter substitute, phospholipid etc.
Coolant agent can be: one or more of Natural menthol, eucalyptus oil, asia peppermint vegetable oil etc.
Organic solvent can be: 85%～99% ethanol.
The consumption of above-mentioned excipient, defoamer, coolant agent, organic solvent is the conventional amount used of this technical field.
For making this product molding and have good mouthfeel and outward appearance better, above-mentioned supplementary product consumption is preferably:
Excipient: white sugar 1-25 part, high maltose syrup 1-20 part;
Defoamer: cocoa butter substitute 0.01-0.1 part, phosphatidase 10 .01-0.1 part;
Coolant agent: Natural menthol 0.02-0.2 part, eucalyptus oil 0.02-0.2 part, asia peppermint vegetable oil 0.02-0.2 part.
Ethanol 0.02-0.2 part of organic solvent: 85%-99%.
preparation method
Pharynx-clearing throat-benefiting buccal tablet of the present invention, its preparation method is:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, decocts with water 2-4 time, filter, and merging filtrate, concentrated, obtain extractum A;
B. get excipient, defoamer is added to the water heating for dissolving, obtains solution B;
C. get coolant agent organic solvent dissolution, obtain solution C;
D. extractum A and solution B are mixed, filter, vacuum boils, and makes most of moisture evaporation, adds solution C to stir, and makes tablet.
In order to send better beneficial effect, i.e. balance between " pharynx-clearing throat-benefiting curative effect " and " preparation production cost ", preferred preparation method is:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, adds water 5-20 doubly, decocts 2-3 time, and each 1-3 hour, filters, merging filtrate, and the extractum that while being concentrated into approximately 80 ℃, relative density is 1.25-1.35, obtains extractum A;
B. get excipient, defoamer is added to the water heating for dissolving, obtains solution B;
C. get coolant agent organic solvent dissolution, obtain solution C;
D. extractum A and solution B are mixed, filter, vacuum boils, and makes most of moisture evaporation, adds solution C to stir, and makes tablet.
the investigation of product clinical efficacy
1. case selection standard
1.1 diagnostic criteria
Symptom: even red swelling and pain of throat, dry laryngopharynx, hoarseness aphonia, the few expectorant of dry cough, dysphagia, bottleneck throat has foreign body sensation.
1.2 inclusive criteria
1. meet above-mentioned diagnostic criteria person.
2. the age is 18-65 year person.
1.3 exclusion standard
1.3.1 do not meet above-mentioned tcm diagnosis standard person.
Though 1.3.2 meet above-mentioned differential diagnosis in tcm standard, there is the one of following situation simultaneously:
1. the age is at under-18s, or over-65s person.
2. pregnant and lying-in women or women breast-feeding their children.
3. be associated with the serious primary disease such as cardiovascular, liver, kidney and hemopoietic system, psychotic.
4. all inclusive criterias that do not meet, not medication in accordance with regulations, cannot judge that curative effect or data are not congruent to affect the treatment and safety judgement person.
2. efficacy determination
(1) clinical recovery medication alleviates with interior symptom for 3 days, within 1 week, with interior clinical symptoms, sign, disappears or substantially disappears.
(2) effective medication alleviates with interior symptom for 1 week, within 2 weeks, with interior clinical symptoms, sign, disappears or substantially disappears.
(3) effectively medication alleviates with interior symptom for 1 week, and within 2 weeks, with interior clinical symptom relief, most of sign disappears.
(4) after invalid medication symptom slightly alleviate or without alleviating, sign is not improved.
3. medication
Get the product of embodiment 1, suck clothes, an a slice, six times on the one, every 2 hours with the last time.
4. result
Adopt the product of embodiment 1 to carry out 51 example tests, result total effective rate reaches 96.1%.
Product curative effect survey result table
| ? | Sum | Clinical recovery | Effective | Effectively | Invalid |
| Number of cases | 51 | 13 | 26 | 10 | 2 |
| Shared percent | 25.5% | 51.0% | 19.6% | 3.9% |
Embodiment
The following example has further described and has proved the embodiment in the scope of the invention.These embodiment are only illustrative, but not limit the scope of the invention, because its many modification are possible in the situation that not deviating from the spirit and scope of the invention.
embodiment 1
Composition of raw materials: Semen Sterculiae Lychnophorae 900g, Flos Chrysanthemi 900g, Radix Platycodonis 400g, Herba Lophatheri 400g
Excipient: white sugar 1500g, high maltose syrup 1000g
Defoamer: cocoa butter substitute 3.5g, phosphatidase 12 g
Coolant agent: Natural menthol 7g, eucalyptus oil 4.5g, asia peppermint vegetable oil 4g
Organic solvent: 95% ethanol 6g
Preparation method:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, decocts with water twice, adds for the first time 20 times of water gagings and extracts 1.5 hours; Adding for the second time 20 times of water gagings extracts 1.5 hours; 200 order filter clothes filter extracting solution, and merging filtrate, is concentrated into relative density 1.28(80 ℃) extractum, obtain extractum A;
B. in jacketed pan, add drinking water 450g, heated and boiled, adds high maltose syrup to stir after adding white sugar to dissolve completely again, adds successively cocoa butter substitute, phospholipid, and stirring and dissolving emulsifying is complete, obtains solution B;
C. get Natural menthol, eucalyptus oil, asia peppermint vegetable oil 95% dissolve with ethanol, obtain solution C;
D. extractum A and solution B are mixed, 80 mesh sieves are filtered in vacuum continuous pan boiling pot, and vacuum boils, and make most of moisture evaporation, and concentrated rear massecuite is pressed into and turns in pot.Temperature is down to approximately 80 ℃, adds while stirring solution C, stirs tabletting, packing.
embodiment 2
Composition of raw materials: Semen Sterculiae Lychnophorae 1200g, Flos Chrysanthemi 700g, Radix Platycodonis 600g, Herba Lophatheri 400g
Excipient: white sugar 2500g, glucose syrup 100g
Defoamer: cocoa butter substitute 5g, phosphatidase 16 .5g
Coolant agent: Natural menthol 16g
Organic solvent: 75% ethanol 18g
Preparation method:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, decocts with water three times, adds for the first time 15 times of water gagings and extracts 3 hours; Adding for the second time 15 times of water gagings extracts 2 hours; Adding for the third time 10 times of water gagings extracts 1 hour; 200 order filter clothes filter extracting solution, and merging filtrate, is concentrated into relative density 1.25(80 ℃) extractum, obtain extractum A;
B. in jacketed pan, add drinking water 800g, heated and boiled, adds glucose syrup to stir after adding white sugar to dissolve completely again, adds successively cocoa butter substitute, phospholipid, and stirring and dissolving emulsifying is complete, obtains solution B;
C. get Natural menthol 75% dissolve with ethanol, obtain solution C;
D. extractum A and solution B are mixed, 90 mesh sieves are filtered in vacuum continuous pan boiling pot, and vacuum boils, and make most of moisture evaporation, and concentrated rear massecuite is pressed into and turns in pot.Temperature is down to approximately 75 ℃, adds while stirring solution C, stirs tabletting, packing.
embodiment 3
Composition of raw materials: Semen Sterculiae Lychnophorae 100g, Flos Chrysanthemi 200g, Radix Platycodonis 1000g, Herba Lophatheri 100g
Excipient: white sugar 800g, high maltose syrup 1800g
Defoamer: cocoa butter substitute 6.5g, phosphatidase 15 g
Coolant agent: eucalyptus oil 6.5g, asia peppermint vegetable oil 5.5g
Organic solvent: 90% ethanol 2g
Preparation method:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, decocts with water twice, adds for the first time 10 times of water gagings and extracts 3 hours; Adding for the second time 5 times of water gagings extracts 2 hours; 200 order filter clothes filter extracting solution, and merging filtrate, is concentrated into relative density 1.35(80 ℃) extractum, obtain extractum A;
B. in jacketed pan, add drinking water 550g, heated and boiled, adds high maltose syrup to stir after adding white sugar to dissolve completely again, adds successively cocoa butter substitute, phospholipid, and stirring and dissolving emulsifying is complete, obtains solution B;
C. get eucalyptus oil, asia peppermint vegetable oil 90% dissolve with ethanol, obtain solution C;
D. extractum A and solution B are mixed, 80 mesh sieves are filtered in vacuum continuous pan boiling pot, and vacuum boils, and make most of moisture evaporation, and concentrated rear massecuite is pressed into and turns in pot.Temperature is down to approximately 70 ℃, adds while stirring solution C, stirs tabletting, packing.
embodiment 4
Composition of raw materials: Semen Sterculiae Lychnophorae 700g, Flos Chrysanthemi 2000g, Radix Platycodonis 100g, Herba Lophatheri 200g
Excipient: white sugar 500g, high maltose syrup 1500g
Defoamer: phosphatidase 11 1g
Coolant agent: Natural menthol 10g, Oleum menthae 1g
Organic solvent: 99% ethanol 9g
Preparation method is:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, decocts with water three times, adds for the first time 20 times of water gagings and extracts 1.5 hours; Adding for the second time 15 times of water gagings extracts 1 hour; Adding for the third time 10 times of water gagings extracts 1 hour; 200 order filter clothes filter extracting solution, and merging filtrate, is concentrated into relative density 1.32(80 ℃) extractum, obtain extractum A;
B. in jacketed pan, add drinking water 650g, heated and boiled, adds high maltose syrup to stir after adding white sugar to dissolve completely again, adds phospholipid, and stirring and dissolving emulsifying is complete, obtains solution B;
C. get Natural menthol, Oleum menthae 99% dissolve with ethanol, obtain solution C;
D. extractum A and solution B are mixed, 100 mesh sieves are filtered in vacuum continuous pan boiling pot, and vacuum boils, and make most of moisture evaporation, and concentrated rear massecuite is pressed into and turns in pot.Temperature is down to approximately 80 ℃, adds while stirring solution C, stirs tabletting, packing.
embodiment 5
Composition of raw materials: Semen Sterculiae Lychnophorae 100g, Flos Chrysanthemi 1200g, Radix Platycodonis 200g, Herba Lophatheri 1000g
Excipient: high maltose syrup 2100g
Defoamer: cocoa butter substitute 11.5g
Coolant agent: Natural menthol 12g, eucalyptus oil 2.5g, asia peppermint vegetable oil 5g
Organic solvent: 90% ethanol 11g
Preparation method:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, decocts with water four times, adds for the first time 15 times of water gagings and extracts 2 hours; Adding for the second time 10 times of water gagings extracts 2 hours; Adding for the third time 10 times of water gagings extracts 1 hour; Adding 10 times of water gagings for the 4th time extracts 1 hour; 200 order filter clothes filter extracting solution, and merging filtrate, is concentrated into relative density 1.28(80 ℃) extractum, obtain extractum A;
B. in jacketed pan, add drinking water 550g, heated and boiled, adds high maltose syrup to stir, then adds cocoa butter substitute, and stirring and dissolving emulsifying is complete, obtains solution B;
C. get Natural menthol, eucalyptus oil, asia peppermint vegetable oil 90% dissolve with ethanol, obtain solution C;
D. extractum A and solution B are mixed, 80 mesh sieves are filtered in vacuum continuous pan boiling pot, and vacuum boils, and make most of moisture evaporation, and concentrated rear massecuite is pressed into and turns in pot.Temperature is down to approximately 60 ℃, adds while stirring solution C, stirs tabletting, packing.
embodiment 6
Composition of raw materials: Semen Sterculiae Lychnophorae 2000g, Flos Chrysanthemi 100g, Radix Platycodonis 400g, Herba Lophatheri 600g
Excipient: white sugar 2300g
Defoamer: cocoa butter substitute 8.5g, monoolein 1g
Coolant agent: asia peppermint vegetable oil 20g
Organic solvent: 85% ethanol 20g
Preparation method:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, decocts with water three times, adds for the first time 20 times of water gagings and extracts 2.5 hours; Adding for the second time 15 times of water gagings extracts 2 hours; Adding for the third time 10 times of water gagings extracts 1 hour; Adding 5 times of water gagings for the 4th time extracts 1 hour; 200 order filter clothes filter extracting solution, and merging filtrate, is concentrated into relative density 1.30(80 ℃) extractum, obtain extractum A;
B. in jacketed pan, add drinking water 600g, heated and boiled, adds white sugar to dissolve completely, adds successively cocoa butter substitute, monoolein, and stirring and dissolving emulsifying is complete, obtains solution B;
C. get asia peppermint vegetable oil 85% dissolve with ethanol, obtain solution C;
D. extractum A and solution B are mixed, 80 mesh sieves are filtered in vacuum continuous pan boiling pot, and vacuum boils, and make most of moisture evaporation, and concentrated rear massecuite is pressed into and turns in pot.Temperature is down to approximately 65 ℃, adds while stirring solution C, stirs tabletting, packing.
The embodiment sample that adopts said method to make, production technology is simple, steady quality, prepared pharynx-clearing throat-benefiting buccal tablet, shape is complete, smooth surface, is faint yellow to brown color, color and luster uniformity, the delicate fragrance local flavor with Flos Chrysanthemi and Herba Lophatheri, refrigerant good to eat, entrance exquisiteness is submissive, dissolves functional.Even for red swelling and pain of throat, dry laryngopharynx, hoarseness aphonia, the few expectorant of dry cough, dysphagia, bottleneck throat has foreign body sensation patient, all obtains good result by above-mentioned sample.
Claims (8)
1. a pharynx-clearing throat-benefiting buccal tablet, is characterized in that, by the crude drug of following weight portion, is made: Semen Sterculiae Lychnophorae 1-20 part, Flos Chrysanthemi 1-20 part, Radix Platycodonis 1-10 part, Herba Lophatheri 1-10 part.
2. pharynx-clearing throat-benefiting buccal tablet according to claim 1, is characterized in that, by the crude drug of following weight portion, is made: Semen Sterculiae Lychnophorae 7-12 part, Flos Chrysanthemi 7-12 part, Radix Platycodonis 2-6 part, Herba Lophatheri 2-6 part.
3. relieving sore-throat by clearing away heat buccal tablet according to claim 1, is characterized in that, by the crude drug of following weight portion, is made: 9 parts of Semen Sterculiae Lychnophoraes, 9 parts of Flos Chrysanthemis, 4 parts of Radix Platycodoniss, 4 parts of Herba Lophatheris.
4. as a preparation method for relieving sore-throat by clearing away heat buccal tablet as described in arbitrary in claim 1-3, comprise the steps:
A. get Semen Sterculiae Lychnophorae, Flos Chrysanthemi, Radix Platycodonis, Herba Lophatheri, roguing respectively, clean, decocts with water 2-4 time, filter, and merging filtrate, concentrated, obtain extractum A;
B. get excipient, defoamer is added to the water heating for dissolving, obtains solution B;
C. get coolant agent organic solvent dissolution, obtain solution C;
D. extractum A and solution B are mixed, filter, vacuum boils, and makes most of moisture evaporation, adds solution C to stir, and makes tablet.
5. the preparation method of relieving sore-throat by clearing away heat buccal tablet according to claim 4, is characterized in that, described excipient is one or both in white sugar and high maltose syrup.
6. the preparation method of relieving sore-throat by clearing away heat buccal tablet according to claim 4, is characterized in that, described defoamer is one or both in cocoa butter substitute and phospholipid.
7. the preparation method of relieving sore-throat by clearing away heat buccal tablet according to claim 4, is characterized in that, described coolant agent is one or more combinations in Natural menthol, eucalyptus oil and asia peppermint vegetable oil.
8. the preparation method of relieving sore-throat by clearing away heat buccal tablet according to claim 4, is characterized in that the ethanol that described organic solvent is 85%～99%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519404A (en) * | 2016-06-20 | 2017-12-29 | 重庆灵方生物技术有限公司 | One kind wets one's whistle anti-inflammatory lozenge |
| CN108308470A (en) * | 2018-04-26 | 2018-07-24 | 江西中医药大学 | Expelling phlegm and arresting coughing drink and its preparation method and application |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073594A (en) * | 2006-05-16 | 2007-11-21 | 中国中医研究院中药研究所 | Method for producing platycodon Root lozenge in treatment of chronic pharyngitis |
| CN102342557A (en) * | 2011-09-21 | 2012-02-08 | 王涛 | Botanical beverage for clearing heat and refreshing mind, clearing liver and improving vision, and clearing pharynx and benefiting throat |
| CN102698106A (en) * | 2012-06-19 | 2012-10-03 | 广西博科药业有限公司 | Lozenge for clearing heat and relieving sore throat and preparation method of lozenge |
-
2013
- 2013-12-23 CN CN201310715424.1A patent/CN103735894A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073594A (en) * | 2006-05-16 | 2007-11-21 | 中国中医研究院中药研究所 | Method for producing platycodon Root lozenge in treatment of chronic pharyngitis |
| CN102342557A (en) * | 2011-09-21 | 2012-02-08 | 王涛 | Botanical beverage for clearing heat and refreshing mind, clearing liver and improving vision, and clearing pharynx and benefiting throat |
| CN102698106A (en) * | 2012-06-19 | 2012-10-03 | 广西博科药业有限公司 | Lozenge for clearing heat and relieving sore throat and preparation method of lozenge |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107519404A (en) * | 2016-06-20 | 2017-12-29 | 重庆灵方生物技术有限公司 | One kind wets one's whistle anti-inflammatory lozenge |
| CN108308470A (en) * | 2018-04-26 | 2018-07-24 | 江西中医药大学 | Expelling phlegm and arresting coughing drink and its preparation method and application |
| CN108308470B (en) * | 2018-04-26 | 2021-10-08 | 江西中医药大学 | Phlegm-eliminating cough-relieving beverage and preparation method and application thereof |
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Address after: 530003, 56 Garden Avenue, Nanning, the Guangxi Zhuang Autonomous Region Applicant after: GUANGXI BOKE PHARMACEUTICAL CO., LTD., GUANGXI Address before: 530003, 56 Garden Avenue, Nanning, the Guangxi Zhuang Autonomous Region Applicant before: Boke Pharmaceutical Co., Ltd., Guangxi |
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Application publication date: 20140423 |