CN108308470B - Phlegm-eliminating cough-relieving beverage and preparation method and application thereof - Google Patents

Phlegm-eliminating cough-relieving beverage and preparation method and application thereof Download PDF

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CN108308470B
CN108308470B CN201810388304.8A CN201810388304A CN108308470B CN 108308470 B CN108308470 B CN 108308470B CN 201810388304 A CN201810388304 A CN 201810388304A CN 108308470 B CN108308470 B CN 108308470B
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parts
cough
phlegm
mulberry
momordica grosvenori
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CN108308470A (en
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万娜
康超超
伍振峰
杨明
朱根华
罗莹
李艳
王芳
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Jiangxi University of Traditional Chinese Medicine
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Abstract

The invention provides a phlegm-eliminating and cough-relieving beverage and a preparation method and application thereof, and relates to the technical field of beverages, wherein the phlegm-eliminating and cough-relieving beverage comprises the following raw materials in parts by mass: 60-100 parts of bamboo shavings, 50-100 parts of lophatherum gracile, 10-50 parts of pear juice, 10-50 parts of momordica grosvenori, 20-50 parts of scaphium scaphigerum, 20-50 parts of medlar and 10-50 parts of mulberry, and the technical problems that the existing western medicines can only inhibit excessive phlegm symptoms in a short time, but can not effectively relieve cough and eliminate phlegm and have large toxic and side effects are solved.

Description

Phlegm-eliminating cough-relieving beverage and preparation method and application thereof
Technical Field
The invention relates to the technical field of beverages, in particular to a phlegm-eliminating and cough-relieving beverage as well as a preparation method and application thereof.
Background
Cough and excessive phlegm are common symptoms of respiratory diseases, the cough is caused by inflammation, foreign matters, physical or chemical stimulation on trachea, bronchial mucosa or pleura, the glottis is closed firstly, respiratory muscles are contracted, the internal pressure of the lung is increased, then the glottis is opened, and air in the lung is sprayed out. Cough with a build-up of fluid expectoration is called expectoration. The disease is possibly suffered by men, women, old and young all the year round, the incidence rate is extremely high, and if the disease is not cured in time, the cough is continuously changed from acute to chronic, and the patient is often suffered from more pain, such as chest distress, pharynx itch, asthma and the like, and even if the symptoms are not aggravated, the rest and sleep are affected.
At present, common medicines for relieving cough and reducing sputum in western medicine comprise ammonium chloride, must dissolve sputum and carbocysteine, which have obvious curative effect on inhibiting short-term excessive phlegm symptoms, but can not effectively relieve cough and reduce sputum. And western medicines are mostly treated by diminishing inflammation and being matched with antibiotic medicines, but the side effects are large, especially antibiotics, the abuse of the antibiotics can cause serious drug resistance, and the cough caused by the chronic bronchitis is not suitable for long-term use of the antibiotics for treatment. In recent years, with the development of society, people are more and more attentive to health preservation, and people are more and more hoped to achieve the purposes of conditioning bodies and preventing diseases through food therapy.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
One of the purposes of the invention is to provide a medicinal and edible phlegm-eliminating and cough-relieving beverage, so as to improve the technical problems that western medicines can only inhibit excessive phlegm symptoms in a short term, but can not effectively relieve cough and eliminate phlegm, and have large toxic and side effects.
The invention provides a phlegm-eliminating cough-relieving drink which comprises the following raw materials in parts by weight: 60-100 parts of bamboo shavings, 50-100 parts of lophatherum gracile, 10-50 parts of pear juice, 10-50 parts of momordica grosvenori, 20-50 parts of scaphium scaphigerum, 20-50 parts of medlar and 10-50 parts of mulberry.
Further, the phlegm-eliminating and cough-relieving drink comprises the following raw materials in parts by weight: 60-90 parts of bamboo shavings, 50-80 parts of lophatherum gracile, 20-40 parts of pear juice, 10-30 parts of momordica grosvenori, 20-30 parts of scaphium scaphigerum, 20-30 parts of medlar and 10-20 parts of mulberry.
Further, the phlegm-eliminating and cough-relieving drink comprises the following raw materials in parts by weight: 60-75 parts of bamboo shavings, 60-75 parts of lophatherum gracile, 25-35 parts of pear juice, 15-25 parts of momordica grosvenori, 20-25 parts of scaphium scaphigerum, 20-25 parts of medlar and 15-20 parts of mulberry.
Furthermore, the phlegm-eliminating and cough-relieving beverage also comprises 20-30 parts of dried lily bulb, 15-30 parts of mulberry leaf and 5-20 parts of platycodon root according to the mass parts.
Furthermore, the phlegm-expelling and cough-relieving drink also comprises 10-100 parts of auxiliary materials;
preferably, the auxiliary material is selected from sweeteners and/or flavors.
The invention also aims to provide a preparation method of the phlegm-eliminating and cough-relieving beverage, which comprises the following steps:
extracting bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia lychnophora, medlar, mulberries, optional dried lily, optional mulberry leaves and optional platycodon grandiflorum to obtain mixed extract of the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberries, the optional dried lily, the optional mulberry leaves and the optional platycodon grandiflorum, uniformly mixing the mixed extract with pear juice, concentrating under reduced pressure, and adding optional auxiliary materials to obtain the phlegm-eliminating and cough-relieving beverage.
Further, mixing the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberry, the optional dried lily, the optional mulberry leaf and the optional platycodon grandiflorum, and then preparing a mixed extracting solution of the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberry, the optional dried lily, the optional mulberry leaf and the optional platycodon grandiflorum by an extraction method.
Further, mixing the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberries, the optional dried lily, the optional mulberry leaves and the optional platycodon grandiflorum, carrying out heating extraction for multiple times, and then mixing extracting solutions obtained by heating extraction for multiple times to obtain a mixed extracting solution of the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberries, the optional dried lily, the optional mulberry leaves and the optional platycodon grandiflorum.
Further, the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberry, the optional dried lily, the optional mulberry leaf and the optional platycodon grandiflorum are soaked for 0.5 to 1.5 hours and then heated and extracted.
The invention also aims to provide the application of the phlegm-eliminating and cough-relieving drink in food, health care products or medicines.
The phlegm-eliminating cough-relieving beverage provided by the invention is compatible by utilizing the food therapy thought of traditional Chinese medicine and the medicine-food homologous theory, through mutual cooperation of bamboo shavings, lophatherum gracile, pear juice, momordica grosvenori, scaphium scaphigerum, medlar and mulberry, not only can be used for quickly eliminating phlegm and relieving cough, but also can be used for preventing cough and expectoration, and meanwhile, all raw materials are all selected from medicine-food homologous plants, are natural and green, are nutritional and healthy, have no toxic or side effect, and accord with the development trend of low-carbon food market.
The preparation method of the phlegm-eliminating and cough-relieving beverage provided by the invention is simple in process and convenient to operate, and can be suitable for industrial mass production, so that the production cost is effectively reduced.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
According to one aspect of the invention, the phlegm-expelling and cough-relieving drink comprises the following raw materials in parts by weight: 60-100 parts of bamboo shavings, 50-100 parts of lophatherum gracile, 10-50 parts of pear juice, 10-50 parts of momordica grosvenori, 20-50 parts of scaphium scaphigerum, 20-50 parts of medlar and 10-50 parts of mulberry.
Typical but not limiting parts by mass of bamboo shavings in the present invention are for example 60, 62, 65, 68, 70, 72, 75, 78, 80, 82, 85, 88, 90, 92, 95, 98 or 100 parts.
The caulis Bambusae in Taenia is sweet in taste, slightly cold and moist in nature, and can be used for clearing heat, relieving vomit, eliminating phlegm, resolving stagnation, clearing heat and relieving restlessness.
Typical but not limiting parts by mass of the lophatherum gracile are for example 50, 52, 55, 58, 60, 62, 65, 68, 70, 72, 75, 78, 80, 82, 85, 88, 90, 92, 95, 98 or 100 parts.
Lophatherum gracile is sweet, bland and cold in flavor, enters heart, lung, stomach and bladder channels, can clear heart, promote urination and eliminate dysphoria, and has good curative effects on swelling and aching of gum, stomatitis and the like.
Typical but non-limiting parts by mass of the pear juice are for example 10, 12, 15, 18, 20, 22, 25, 28, 30, 32, 35, 38, 40, 42, 45, 48 or 50 parts.
The pear juice is sweet, sour and flat in taste, has the effects of moistening lung, clearing dryness, relieving cough, reducing phlegm, promoting urination, relieving fever, nourishing blood and promoting granulation, has good effects on throat dryness, itching, pain, hoarseness, thick phlegm and the like, and is obtained by juicing snow pears and filtering.
Typical but not limiting parts by mass of luo han guo are for example 10, 12, 15, 18, 20, 22, 25, 28, 30, 32, 35, 38, 40, 42, 45, 48 or 50 parts.
Fructus Siraitiae Grosvenorii has effects of moistening lung, relieving cough, promoting fluid production, and quenching thirst.
Typical but not limiting parts by mass of scaphium scaphigerum are, for example, 20, 22, 25, 28, 30, 32, 35, 38, 40, 42, 45, 48 or 50 parts.
Boat-fruited sterculia seed, semen sterculiae lychnophorae, sweet in taste and cold in nature, is light in weight and disperses, enters lung meridian and clears and disperses lung qi, is a good medicine for laryngology; the lower one enters the large intestine to clear intestine and relieve constipation, so it is indicated for the syndrome of upper fire-toxin due to constipation due to heat accumulation.
Typical but not limiting parts by mass of lycium barbarum are, for example, 20, 22, 25, 28, 30, 32, 35, 38, 40, 42, 45, 48 or 50 parts.
The medlar has the functions of nourishing the liver, nourishing the kidney and moistening the lung, and can be used for tonifying the lung and the kidney for the deficiency of lung qi and kidney qi of patients with cough and expectoration.
Typical but not limiting mass fractions of mulberry are for example 10, 12, 15, 18, 20, 22, 25, 28, 30, 32, 35, 38, 40, 42, 45, 48 or 50 parts.
The mulberry is sweet and sour, has sweet and sweet taste, is sweet and sour, and has the effects of tonifying liver, strengthening spleen and kidney, promoting the production of body fluid and lubricating intestines and treating liver and kidney yin deficiency.
The phlegm-eliminating cough-relieving beverage provided by the invention is compatible by utilizing the food therapy thought of traditional Chinese medicine and the medicine-food homologous theory, through mutual cooperation of bamboo shavings, lophatherum gracile, pear juice, momordica grosvenori, scaphium scaphigerum, medlar and mulberry, not only can be used for quickly eliminating phlegm and relieving cough, but also can be used for preventing cough and expectoration, and meanwhile, all raw materials are all selected from medicine-food homologous plants, are natural and green, are nutritional and healthy, have no toxic or side effect, and accord with the development trend of low-carbon food market.
In a further preferred embodiment of the invention, the phlegm-expelling and cough-relieving beverage further comprises 20-30 parts of dried lily bulb, 15-30 parts of mulberry leaf and 5-20 parts of platycodon root by mass.
In this preferred embodiment of the invention, the typical but non-limiting mass fraction of dried lily is, for example, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30 parts.
The dried lily has high medicinal value. Detoxicating, regulating spleen and invigorating stomach, promoting diuresis, resolving food stagnation, calming heart, tranquilizing mind, and promoting blood circulation. It can be used for treating cough, hemoptysis, vexation, palpitation, and has special effects in treating diseases of pulmonary collaterals, promoting health, and resisting aging.
In the preferred embodiment of the present invention, typical but not limiting parts by mass of mulberry leaves are, for example, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 or 30 parts.
The mulberry leaves are bitter in taste, sweet and cold in nature, enter lung channels and liver channels, and have the effects of clearing and nourishing liver, dispelling wind and heat, clearing lung and improving eyesight.
In this preferred embodiment of the invention, typical but not limiting parts by mass of platycodon grandiflorum are, for example, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 parts.
The balloonflower root has the functions of dispersing lung qi, relieving sore throat, eliminating phlegm and expelling pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation.
In a preferred embodiment of the invention, the expectorant and antitussive beverage further comprises 200 parts of 100-one auxiliary materials.
In a preferred embodiment of the invention, typical but not limiting parts by mass of the auxiliary material are, for example, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 or 100 parts.
In a further preferred embodiment of the invention, the auxiliary material is selected from sweeteners and/or flavours.
The sweetener includes but is not limited to one or more of isomaltulose, xylitol, maltose, mannitol or white sugar.
Flavors include, but are not limited to, mint, grape or strawberry flavors; still more preferably, the essence is a natural plant essence.
According to a second aspect of the invention, the invention provides a preparation method of a phlegm-expelling and cough-relieving beverage, which comprises the following steps:
extracting bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia lychnophora, medlar, mulberries, optional dried lily, optional mulberry leaves and optional platycodon grandiflorum to obtain mixed extract of the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberries, the optional dried lily, the optional mulberry leaves and the optional platycodon grandiflorum, uniformly mixing the mixed extract with pear juice, concentrating under reduced pressure, and adding optional auxiliary materials to obtain the phlegm-eliminating and cough-relieving beverage.
The preparation method of the phlegm-eliminating and cough-relieving beverage provided by the invention is simple in process and convenient to operate, and can be suitable for industrial mass production, so that the production cost is effectively reduced.
In a further preferred embodiment of the present invention, the mixed extract of bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia scaphigera, lycium barbarum, mulberries, optionally dried lilies, optionally mulberry leaves and optionally platycodon grandiflorum is prepared by mixing and extracting the mixture of bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia scaphigera, lycium barbarum, mulberries, optionally dried lilies, optionally dried mulberry leaves and optionally platycodon grandiflorum.
The preparation method is characterized in that the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberry, the optional dried lily, the optional mulberry leaf and the optional platycodon grandiflorum are mixed, and then the extraction of the effective ingredients of the raw materials is carried out, so that the process is simplified, the preparation efficiency is improved, and the production cost is reduced.
In a preferred embodiment of the present invention, the mixed extract of bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia scaphigera, lycium barbarum, mulberries, optionally dried lilies, optionally mulberry leaves and optionally platycodon grandiflorum is obtained by mixing, performing multiple times of heating and leaching, and then mixing the extracts obtained by multiple times of heating and leaching.
The effective components of the raw materials are fully extracted by heating and leaching the mixture of bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia lychnophora, medlar, mulberry, optional dried lily, optional mulberry leaf and optional platycodon grandiflorum for a plurality of times, so that the phlegm eliminating and cough relieving effects are further improved.
In a preferred embodiment of the present invention, the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberry, the optional dried lily, the optional mulberry leaf and the optional platycodon grandiflorum are soaked for 0.5 to 1.5 hours, and then the heating and the extraction are performed.
The preparation method comprises the steps of mixing bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia lychnophora, medlar, mulberries, optional dried lily, optional mulberry leaves and optional platycodon grandiflorum, and then adding water to soak for 0.5-2 hours, so that the subsequent extraction process is accelerated, and the extraction efficiency is improved.
In a typical but non-limiting embodiment of the invention, the soaking in water is for a period of time such as 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, or 1.5 hours.
According to a third aspect of the invention, the invention provides the application of the phlegm-eliminating and cough-relieving drink in food, medicines or health products.
In the present invention, food products include, but are not limited to, liquid beverages and solid beverages.
The medicine includes but is not limited to oral liquid, decoction and the like.
The technical solution provided by the present invention is further described below with reference to examples and comparative examples.
Example 1
The embodiment provides a solid beverage particle for eliminating phlegm and stopping cough, which comprises the following raw materials in parts by mass: 60 parts of bamboo shavings, 100 parts of lophatherum gracile, 10 parts of pear juice, 50 parts of momordica grosvenori, 20 parts of scaphium scaphigerum, 50 parts of medlar and 10 parts of mulberry.
Example 2
The embodiment provides a solid beverage particle for eliminating phlegm and stopping cough, which comprises the following raw materials in parts by mass: 100 parts of bamboo shavings, 50 parts of lophatherum gracile, 50 parts of pear juice, 10 parts of momordica grosvenori, 50 parts of scaphium scaphigerum, 20 parts of medlar and 50 parts of mulberry.
Example 3
The embodiment provides a solid beverage particle for eliminating phlegm and stopping cough, which comprises the following raw materials in parts by mass: 90 parts of bamboo shavings, 50 parts of lophatherum gracile, 40 parts of pear juice, 10 parts of momordica grosvenori, 30 parts of scaphium scaphigerum, 20 parts of medlar and 20 parts of mulberry.
Example 4
The embodiment provides a solid beverage particle for eliminating phlegm and stopping cough, which comprises the following raw materials in parts by mass: 60 parts of bamboo shavings, 80 parts of lophatherum gracile, 20 parts of pear juice, 30 parts of momordica grosvenori, 20 parts of scaphium scaphigerum, 30 parts of medlar and 10 parts of mulberry.
Example 5
The embodiment provides a solid beverage particle for eliminating phlegm and stopping cough, which comprises the following raw materials in parts by mass: 60 parts of bamboo shavings, 75 parts of lophatherum gracile, 25 parts of pear juice, 25 parts of momordica grosvenori, 20 parts of scaphium scaphigerum, 25 parts of medlar and 15 parts of mulberry.
Example 6
The embodiment provides a solid beverage particle for eliminating phlegm and stopping cough, which comprises the following raw materials in parts by mass: 75 parts of bamboo shavings, 60 parts of lophatherum gracile, 35 parts of pear juice, 15 parts of momordica grosvenori, 25 parts of scaphium scaphigerum, 20 parts of medlar and 20 parts of mulberry.
Example 7
The embodiment provides a solid beverage particle for eliminating phlegm and stopping cough, which comprises the following raw materials in parts by mass: 65 parts of bamboo shavings, 65 parts of lophatherum gracile, 30 parts of pear juice, 20 parts of momordica grosvenori, 24 parts of scaphium scaphigerum, 24 parts of medlar and 16 parts of mulberry.
Example 8
The embodiment provides a solid beverage particle for eliminating phlegm and stopping cough, and is different from the embodiment 7 in that the solid beverage particle further comprises 25 parts of dried lily bulb, 25 parts of mulberry leaf and 10 parts of platycodon grandiflorum in parts by mass.
Example 9
This example provides a solid beverage granule for eliminating phlegm and arresting coughing, and is different from example 8 in that dried lily is not added.
Example 10
This example provides a solid beverage granule for eliminating phlegm and arresting coughing, and is different from example 8 in that no mulberry leaves are added.
Example 11
This example provides a solid beverage granule for eliminating phlegm and arresting coughing, and is different from example 8 in that balloon flower is not added.
Example 12
This example provides a solid beverage granule for eliminating phlegm and arresting coughing, and is different from example 8 in that dried lily and mulberry leaves are not added.
Example 13
This example provides a solid beverage granule for eliminating phlegm and arresting coughing, and is different from example 8 in that dried lily bulb and platycodon root are not added.
Example 14
This example provides a solid beverage granule for eliminating phlegm and arresting coughing, and is different from example 8 in that platycodon grandiflorum and mulberry leaves are not added.
Example 15
Example 15 provides a method for preparing solid beverage granules for eliminating phlegm and relieving cough, and the solid beverage granules for eliminating phlegm and relieving cough provided in examples 1 to 14 are prepared according to the following steps:
(a) mixing caulis Bambusae in Taenia, folium Bambusae, fructus Siraitiae Grosvenorii, semen Scaphii Lychnophori, fructus Lycii, Mori fructus, optionally dried Bulbus Lilii, optionally folium Mori and optionally radix Platycodi, and soaking in water for 1 hr;
(b) heating and leaching the soaked bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia lychnophora, medlar, mulberries, optional dried lily, optional mulberry leaves and optional platycodon grandiflorum for multiple times at 85 ℃, and combining the leaching liquor and the soaking liquor for multiple times to obtain mixed extracting liquor of the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the mulberries, the optional dried lily, the optional mulberry leaves and the optional platycodon grandiflorum;
(c) mixing the mixed extractive solution and succus Pyri, concentrating under reduced pressure, stirring, drying at 60 deg.C, pulverizing, sieving, adding water to make soft material, and granulating with 16 mesh screen; drying at 60 deg.C, grading, and mixing to obtain solid beverage granule with expectorant and antitussive effects.
Comparative example 1
The comparative example provides a solid beverage particle for eliminating phlegm and relieving cough, which comprises the following components in parts by weight: 20 parts of bamboo shavings, 110 parts of lophatherum gracile, 5 parts of pear juice, 60 parts of momordica grosvenori, 10 parts of scaphium scaphigerum, 60 parts of medlar and 55 parts of mulberry.
Comparative example 2
The comparative example provides a solid beverage particle for eliminating phlegm and relieving cough, which comprises the following components in parts by weight: 100 parts of bamboo shavings, 30 parts of lophatherum gracile, 60 parts of pear juice, 5 parts of momordica grosvenori, 60 parts of scaphium scaphigerum, 10 parts of medlar and 5 parts of mulberry.
Comparative example 3
This comparative example provides a solid beverage granule for eliminating phlegm and arresting coughing, and this example differs from example 7 in that 130 parts of bamboo shavings are not added with lophatherum gracile.
Comparative example 4
This comparative example provides a solid beverage granule for eliminating phlegm and arresting coughing, and this example differs from example 7 in that 130 parts of lophatherum gracile is not added with bamboo shavings.
Comparative example 5
This comparative example provides a solid drink granule for eliminating phlegm and arresting coughing, and this example differs from example 7 in that pear juice is not added.
Comparative example 6
This comparative example provides a solid drink granule for eliminating phlegm and arresting coughing, and this example is different from example 7 in that momordica grosvenori is not added.
Comparative example 7
This comparative example provides a solid beverage granule for eliminating phlegm and arresting coughing, and this example is different from example 7 in that boat-fruited sterculia seed is not added.
Comparative example 8
This comparative example provides a solid drink granule for eliminating phlegm and arresting coughing, and this example differs from example 7 in that no wolfberry is added.
Comparative example 9
This comparative example provides a solid beverage granule for eliminating phlegm and arresting coughing, and this example is different from example 7 in that no mulberry is added.
The preparation method of the solid beverage granules for eliminating phlegm and stopping cough provided by the comparative examples 1 to 9 is the same as that of example 7, and the details are not repeated.
Test example 1 mouse Ammonia-induced cough test
250 mice (each half of a female and a male) with 20g +/-2 g of Kunming seeds are taken, and are randomly divided into 25 groups according to the weight after being adaptively fed for 3 days: control group, positive group, example groups 1-14, comparative example groups 1-9, 10 of each group, were fasted without water deprivation for 12h before the experiment. The administration was performed by gavage according to the dose shown in Table 1, 0.9% physiological saline was administered to the control group, the drug codeine was administered to the positive group, and the administration was continued for 3 days, starting the experiment 1h after the last administration. The mice were placed in a 500ml glass bell jar, 25% -28% concentrated ammonia water was quantitatively sprayed, the mice were taken out after being stimulated for 20s in an ammonia gas environment, and the cough latency and the number of coughs within 5min of the mice were observed and recorded as shown in table 2.
TABLE 1 dosage days mode table for ammonia water induced cough test of mice
Figure GDA0003191657010000121
Figure GDA0003191657010000131
TABLE 2 cough latency and number of coughs within 5min for mice
Figure GDA0003191657010000132
Figure GDA0003191657010000141
Note: p <0.01, P <0.05 compared to control.
As can be seen from comparison between examples 1 to 14 and a control group in table 2, the solid beverage particles for eliminating phlegm and relieving cough provided in examples 1 to 14 have a significant cough-relieving effect by mutual synergy of bamboo shavings, lophatherum gracile, pear juice, momordica grosvenori, boat-fruited sterculia seed, medlar and mulberry, and can significantly prolong the incubation period of cough and reduce the number of coughs within 5 min.
As can be seen from comparison between examples 1-7 and comparative examples 1-9, the cough relieving effect of the solid beverage particles for eliminating phlegm and relieving cough prepared by the mutual synergy of the bamboo shavings, the lophatherum gracile, the pear juice, the momordica grosvenori, the sterculia lychnophora, the medlar and the mulberry in specific parts by mass is more remarkable, the cough latency period is longer, and the cough frequency within 5min is less.
As can be seen from comparison between the example 8 and the examples 1 to 7, the cough relieving effect of the solid drink granules for expelling phlegm and arresting cough, which are prepared by adding dried lily, mulberry leaves and platycodon grandiflorum into the raw materials and mutually cooperating the bamboo shavings, the lophatherum gracile, the pear juice, the momordica grosvenori, the boat-fruited sterculia seed, the medlar and the mulberry according to specific mass parts, is remarkably improved, the cough latency period is further prolonged, and the cough frequency within 5min is further reduced.
As can be seen from comparison between the example 8 and the examples 9 to 14, the cough relieving effect of the solid beverage particles for eliminating phlegm and stopping cough, which is prepared by adding dried lily, mulberry leaves and platycodon grandiflorum in raw materials and mutually cooperating the dried lily, the mulberry leaves and the platycodon grandiflorum in specific parts by mass with bamboo shavings, lophatherum gracile, pear juice, momordica grosvenori, boat-fruited sterculia seed, medlar and mulberry, is remarkably higher than that of the solid beverage particles for eliminating phlegm and stopping cough, which is prepared by adding single dried lily, mulberry leaves or platycodon grandiflorum raw materials or adding the two raw materials, which shows that the dried lily, the mulberry leaves and the platycodon grandiflorum can generate a synergistic effect, so that the cough relieving effect of the solid beverage particles for eliminating phlegm and stopping cough is greatly improved.
As can be seen by comparing examples 7-8 with the positive group, the cough relieving effect of the solid beverage granules for eliminating phlegm and relieving cough provided by examples 7-8 is equivalent to that of codeine with the same dose, but the raw materials adopted by the solid beverage granules for eliminating phlegm and relieving cough provided by the embodiment are all taken from medicinal and edible plants, have no toxic or side effect, and can achieve the effects of conditioning the body and preventing cough while carrying out food therapy on people.
Test example 2 mouse (expectorant) test
250 mice (each half of a female and a male) with 20g +/-2 g of Kunming seeds are taken, are adaptively fed for 3 days, and are randomly divided into 25 groups according to the weight: control group, positive group, examples 1-14 group, comparative examples 1-9 group, 10 of each group, labeled, fasted without water deprivation for 12h before experiment. The administration is performed by intragastric administration according to the dosage shown in the table 3, 0.9% normal saline is administered to the control group, the administration is continuously performed for 7 days, after 30min of the last administration, the urethane is 1.0g/kg, and the patient is fixed in the supine position after the anesthesia of the intraperitoneal injection. The skin in the middle of the neck is cut open, and the air outlet pipe is separated. A hole is pricked by a sharp injection needle between cartilage rings at the center of the lower edge of the thyroid cartilage, and then a glass capillary is inserted, so that the capillary just contacts the surface of the bottom of a trachea, thereby sucking the sputum at the rear part of the trachea. When the capillary tube was full of sputum, one capillary tube was immediately replaced, and the weight of the sputum drawn by the capillary tube was used as the evaluation of the expectorant effect of the drug and was statistically analyzed, and the results are shown in table 4.
Table 3: dosing dose days mode table for mouse phlegm eliminating test
Figure GDA0003191657010000161
Figure GDA0003191657010000171
TABLE 4 mouse trachea sputum discharge data sheet
Figure GDA0003191657010000172
Figure GDA0003191657010000181
Note: p <0.01, P <0.05 compared to control.
As can be seen from comparison between examples 1 to 14 and a control group in table 4, the solid beverage particles for eliminating phlegm and arresting coughing provided in examples 1 to 14 have a significant effect of eliminating phlegm and can significantly increase the amount of phlegm discharged by the mutual synergy of bamboo shavings, lophatherum gracile, pear juice, momordica grosvenori, boat-fruited sterculia seed, medlar and mulberry.
As can be seen from comparison between examples 1-7 and comparative examples 1-9, the phlegm-eliminating and cough-relieving solid beverage particles prepared by the mutual synergy of the bamboo shavings, the lophatherum gracile, the pear juice, the momordica grosvenori, the scaphium scaphigerum, the medlar and the mulberry in specific parts by mass have more remarkable phlegm-eliminating effect and more phlegm-eliminating amount.
As can be seen from the comparison between the example 8 and the examples 1 to 7, the phlegm-eliminating and cough-relieving solid beverage particles prepared by adding dried lily, mulberry leaves and platycodon grandiflorum to the raw materials and mutually cooperating the bamboo shavings, the lophatherum gracile, the pear juice, the momordica grosvenori, the boat-fruited sterculia seed, the medlar and the mulberry according to specific parts by mass have the advantages of obviously improved phlegm-eliminating effect and further increased phlegm discharge amount.
As can be seen from the comparison between the example 8 and the examples 9 to 14, the cough relieving effect of the solid beverage particles for eliminating phlegm and stopping cough, which are prepared by adding the dried lily, the mulberry leaves and the platycodon grandiflorum in the raw materials and mutually cooperating the bamboo shavings, the lophatherum gracile, the pear juice, the momordica grosvenori, the boat-fruited sterculia seed, the medlar and the mulberry in specific parts by mass, is remarkably higher than that of the raw materials of the dried lily, the mulberry leaves or the platycodon grandiflorum or the two raw materials, which shows that the dried lily, the mulberry leaves and the platycodon grandiflorum can generate a synergistic effect, so that the phlegm eliminating effect of the solid beverage particles for eliminating phlegm and stopping cough is greatly improved.
As can be seen by comparing examples 7-8 with the positive group, the cough relieving effect of the solid beverage granules for eliminating phlegm and stopping coughing provided by examples 7-8 is equivalent to that of ammonium chloride with the same dose, but the raw materials adopted by the solid beverage granules for eliminating phlegm and stopping coughing provided by the embodiment are all taken from medicinal and edible plants, have no toxic or side effect, and can achieve the effects of conditioning bodies and preventing coughs while people carry out food therapy.
Test example 3 mouse toxicity test
By adopting a maximum dosage test method, 60 Kunming mice (female and male half) with 20g +/-2 g of Kunming species are randomly divided into 3 groups, namely a control group, an example 7 group and an example 8 group, wherein 20 mice in each group are gavaged for 2 times at 24h and 6h intervals at 2 times with dosage of 40g/kg of body weight, and the behavior activity, mental state, fur skin color, stool and weight change of the animals are observed for 14 days continuously.
The results show that after the administration, the 3 groups of mice have no abnormal change in physical signs such as behavioral activity, mental state, fur skin color, stool and secretion, and the weight change is within a normal range (P is less than 0.05); after observation, no abnormal pathological changes of main organs are found in mice autopsy. The result shows that the solid beverage particles for eliminating phlegm and stopping coughing do not have obvious acute toxic reaction.
The comprehensive test examples 1-3 show that the phlegm-eliminating cough-relieving beverage provided by the invention utilizes the food therapy thought of traditional Chinese medicine and the formula compatibility of medicinal and edible theory components, through the mutual cooperation of the bamboo shavings, the lophatherum gracile, the pear juice, the momordica grosvenori, the boat-fruited sterculia seed, the medlar and the mulberry, the phlegm-eliminating cough-relieving beverage can quickly eliminate the phlegm and relieve the cough, can prevent the occurrence of cough and expectoration, simultaneously all the raw materials are selected from medicinal and edible plants, are natural and green, are nutritional and healthy, have no toxic or side effect, and accord with the development trend of the low-carbon food market.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims (6)

1. The phlegm-eliminating and cough-relieving drink is characterized by being prepared from the following raw materials in parts by mass: 65 parts of bamboo shavings, 65 parts of lophatherum gracile, 30 parts of pear juice, 20 parts of momordica grosvenori, 24 parts of scaphium scaphigerum, 24 parts of medlar, 16 parts of mulberry, 25 parts of dried lily bulb, 25 parts of mulberry leaf and 10 parts of platycodon grandiflorum.
2. The preparation method of the phlegm expelling and cough relieving drink according to claim 1, which is characterized by comprising the following steps:
extracting bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia lychnophora, medlar, mulberry, dried lily, mulberry leaves and platycodon grandiflorum to obtain mixed extracting solution of the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberry, the dried lily, the mulberry leaves and the platycodon grandiflorum, uniformly mixing the mixed extracting solution with pear juice, and concentrating under reduced pressure to obtain the phlegm-eliminating and cough-relieving drink.
3. The method for preparing a phlegm-expelling and cough-relieving beverage according to claim 2, wherein the mixed extract of the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberries, the dried lilies, the mulberry leaves and the platycodon grandiflorum is prepared by mixing the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the mulberries, the dried lilies, the mulberry leaves and the platycodon grandiflorum through an extraction method.
4. The method for preparing a phlegm-expelling and cough-relieving beverage according to claim 2, wherein the mixed extract of bamboo shavings, lophatherum gracile, momordica grosvenori, sterculia lychnophora, medlar, mulberries, dried lilies, mulberry leaves and platycodon grandiflorum is obtained by mixing the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the dried lilies, the mulberry leaves and the platycodon grandiflorum, carrying out multiple times of heating extraction, and then mixing the extract obtained by multiple times of heating extraction.
5. The method for preparing a phlegm-expelling and cough-relieving beverage according to claim 4, wherein the bamboo shavings, the lophatherum gracile, the momordica grosvenori, the sterculia lychnophora, the medlar, the mulberry, the dried lily, the mulberry leaves and the platycodon grandiflorum are soaked for 0.5 to 1.5 hours, and then are heated and extracted.
6. Use of the expectorant and antitussive beverage according to claim 1 in the preparation of a health food or a pharmaceutical product.
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