CN116270896B - Traditional Chinese medicine composition for treating livestock and poultry cough and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating livestock and poultry cough and preparation method thereof Download PDFInfo
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- CN116270896B CN116270896B CN202310408347.9A CN202310408347A CN116270896B CN 116270896 B CN116270896 B CN 116270896B CN 202310408347 A CN202310408347 A CN 202310408347A CN 116270896 B CN116270896 B CN 116270896B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating livestock and poultry cough and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-25 parts of large tile, 15-25 parts of stinky tree, 9-15 parts of stone string, 9-15 parts of white flowers, 9-15 parts of glossy privet roots, 5-10 parts of green tangerine peel and the like. The traditional Chinese medicine composition provided by the invention belongs to a pure traditional Chinese medicine composition, has reasonable formula compatibility, can play a role in synergy among the raw material components, has no toxic or side effect, no drug resistance and no palatability, and has the effects of dispersing lung qi, eliminating phlegm, relieving cough and asthma.
Description
Technical Field
The invention relates to the technical field of traditional Chinese veterinary medicines, in particular to a traditional Chinese medicine composition for treating livestock and poultry cough and a preparation method thereof.
Background
The lung is called the waggon of the five zang-organs and six fu-organs, also called the jiao-zang organ, which is the main respiratory organ and its function is to govern qi of the whole body. The lung is located in the upper energizer and is connected with the outside, and various pathogenic factors often attack the lung first to cause respiratory diseases, which lead to dysfunction of the lung in dispersing and descending to cause cough, and the cause of cough may be foreign matters, inflammation, secretion or allergic factors.
The traditional Chinese medicine has long history of understanding cough, and focuses on treatment based on syndrome differentiation. The traditional Chinese medicine considers that cough is caused by exogenous six-exogenous pathogenic factors, internal injury of viscera and influence on lung to produce sound and phlegm. The description of "the Qi-Yi-Bao-Ming-Ji for the disease" is as follows: cough without phlegm and with sound and lung qi injury and unclear; cough is silent and has phlegm, spleen dampness moving and also has phlegm. Cough is a phlegm and a sound, and cough is also a cough due to lung qi damage and spleen dampness. This disease is caused by the invasion of exogenous pathogenic factors into the lung or internal injury of viscera affecting the lung. Cough caused by exogenous pathogenic factors and cough caused by internal injury are caused by the condition that lung qi is not clear but is not clear and descending, and qi is forced to flow upwards. Cough lesions are mainly hidden in the lung. The nature of exogenous cough is excessive, which is caused by obstruction of lung qi due to invasion of exogenous pathogenic factors into the lung. The pathological factors are wind, cold, summer-heat, dryness, dampness and fire, wind-cold is excessive, wind-cold heat and wind-heat dryness can occur in the pathological process, or lung heat steaming liquid becomes phlegm and other pathological transformations, and the pathological transformation is often accompanied with viscera dysfunction syndrome. The cough due to wind-cold or wind-heat is caused by the disorder of qi movement of the lung.
The cough of the livestock and poultry is caused by: firstly, respiratory diseases such as sphagitis can cause dry cough, and also tracheitis, bronchitis, bronchial asthma and the like can cause cough by stimulating the trachea and the bronchus. And secondly, the cough is caused by pneumonia or airway inflammation due to cold, physical and chemical factor stimulation, body resistance reduction and infection of conditional pathogenic bacteria such as tuberculosis, streptococcus, staphylococcus, mycoplasma or parasites. In addition, diarrhea, meningitis, traumatic rib fractures, traumatic pericarditis, etc. can also cause coughing. The cough has immeasurable influence on livestock and poultry cultivation, for example, once the cough symptoms of laying ducks are found, the egg yield is reduced, the size and quality of eggs are also problematic, and even other diseases can be caused. The cough and asthma of the pigs and sheep can not cause serious illness, but the infection speed is high, the cough and asthma of the pigs and sheep are easy to relapse, and the effect on the breeding benefit is extremely large. Therefore, to treat the cough of livestock and poultry, the cough is prevented and treated in time by using medicaments, and usually, the cough is treated by using an antitussive medicament.
Currently, various antibiotic drugs such as chloramphenicol and terramycin are most commonly used for treating cough in livestock and poultry cultivation, however, in recent years, along with abuse of antibiotics, the drug resistance of bacteria is stronger, the development speed of new drugs is far lower than the drug resistance speed of bacteria, once certain bacteria generate drug resistance, the drug resistance is difficult to restore the sensitivity of the bacteria to antibiotics, and the drugs generally have hepatotoxicity, drug residues, drug resistance and the like, which affect the quality of livestock and poultry products and the health of dining tables of people. In addition, antibiotics can inhibit and kill beneficial bacteria in the body when acting on pathogenic bacteria, so that flora imbalance in intestinal tracts is caused, and harmful bacteria in the body can enter while the bacteria are still deficient, so that exogenous infection is caused. Therefore, the development of the traditional Chinese medicine composition for treating the livestock and poultry cough has the advantages of remarkable effect, reasonable compatibility, low cost and safe use.
Disclosure of Invention
In a first aspect, the invention provides a traditional Chinese medicine composition for treating livestock and poultry cough, which is prepared from the following traditional Chinese medicine raw materials in parts by weight, 15-25 parts of large tile, 15-25 parts of peppery tree, 9-15 parts of clematis chinensis, 9-15 parts of white flower, 9-15 parts of glossy privet root, 5-10 parts of green tangerine peel, 3-9 parts of liquorice, 9-15 parts of platycodon grandiflorum, 5-10 parts of lily and 5-10 parts of bighead atractylodes rhizome.
Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials, by weight, 18-23 parts of large tile, 18-23 parts of stinky tree, 13-15 parts of clematis chinensis, 9-10 parts of white flowers, 9-10 parts of glossy privet roots, 8-10 parts of green tangerine peel, 3-5 parts of liquorice, 14-15 parts of platycodon grandiflorum, 8-10 parts of lily and 6-8 parts of bighead atractylodes rhizome.
Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight, 23 parts of large tile, 23 parts of peppery tree, 15 parts of clematis chinensis, 9 parts of white flowers, 9 parts of glossy privet roots, 10 parts of green tangerine peel, 5 parts of liquorice, 15 parts of platycodon grandiflorum, 9 parts of lily and 6 parts of bighead atractylodes rhizome.
In a second aspect, the invention provides a preparation of a traditional Chinese medicine composition for treating livestock and poultry cough, which is prepared from the following traditional Chinese medicine raw materials, by weight, 15-25 parts of large tile, 15-25 parts of stinky tree, 9-15 parts of clematis chinensis, 9-15 parts of white flower, 9-15 parts of glossy privet root, 5-10 parts of green tangerine peel, 3-9 parts of liquorice, 9-15 parts of platycodon grandiflorum, 5-10 parts of lily and 5-10 parts of bighead atractylodes rhizome.
Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials, by weight, 18-23 parts of large tile, 18-23 parts of stinky tree, 13-15 parts of clematis chinensis, 9-10 parts of white flowers, 9-10 parts of glossy privet roots, 8-10 parts of green tangerine peel, 3-5 parts of liquorice, 14-15 parts of platycodon grandiflorum, 8-10 parts of lily and 6-8 parts of bighead atractylodes rhizome.
Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight, 23 parts of large tile, 23 parts of peppery tree, 15 parts of clematis chinensis, 9 parts of white flowers, 9 parts of glossy privet roots, 10 parts of green tangerine peel, 5 parts of liquorice, 15 parts of platycodon grandiflorum, 9 parts of lily and 6 parts of bighead atractylodes rhizome.
Further, the pharmaceutical preparation comprises a pharmaceutical composition for treating livestock and poultry cough and pharmaceutically acceptable auxiliary materials.
Furthermore, the auxiliary materials are medicinal auxiliary materials which have the effects of enhancing curative effect, reducing toxicity and/or relieving side effects on the main medicine.
Further, the pharmaceutical auxiliary material can be a liquid auxiliary material or a solid auxiliary material.
Further, the liquid auxiliary materials include, but are not limited to, wine, rice vinegar, honey, saline solution, ginger juice, black bean juice, bile, sesame oil and rice swill.
Further, the solid auxiliary materials include, but are not limited to, rice, wheat bran, alum, bean curd, kitchen soil, clam powder, talcum powder, river sand and cinnabar.
Further, the preparation of the traditional Chinese medicine composition can be a paste, a pill, a pellet, a decoction, a granule, a capsule, a powder, a tablet and the like.
In a third aspect, the invention provides a preparation method of a traditional Chinese medicine composition preparation for treating livestock and poultry cough, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines, by weight, 15-25 parts of large tile, 15-25 parts of stinky tree, 9-15 parts of clematis chinensis, 9-15 parts of white flower, 9-15 parts of glossy privet root, 5-10 parts of green tangerine peel, 3-9 parts of liquorice, 9-15 parts of platycodon grandiflorum, 5-10 parts of lily and 5-10 parts of bighead atractylodes rhizome, and the preparation method comprises the following steps:
s01, weighing the raw materials according to the parts by weight, and cutting into segments;
s02, mixing the processed raw materials into an extraction tank, adding water with the weight which is 8-12 times of the total weight of the raw materials, firstly soaking for 0.5-1 h, and then decocting with slow fire for 1-2 h after boiling;
s03, filtering the traditional Chinese medicines, and adding water which is 7-10 times of the total weight of the medicinal materials into filter residues for decoction for 1-2 h;
s04, continuously filtering the traditional Chinese medicines, and adding water which is 6-8 times of the total weight of the medicinal materials to decoct for 1-2 h;
s05, merging the three decocted liquid medicines, overnight, centrifuging to obtain supernatant, concentrating the liquid medicine until the crude drug amount is 1-3 g/mL, sterilizing to obtain a finished product, and refrigerating at 2-8 ℃ for later use.
In a fourth aspect, the invention provides an application of a traditional Chinese medicine composition in preparing a medicine for treating livestock and poultry cough.
The medicine properties and effects of the traditional Chinese medicinal materials are as follows:
large tile: pungent taste and warm; enter the lung, heart, liver and kidney meridians. Dispelling wind and cold, dispersing lung qi and relieving cough, and relieving pain and swelling. Wind-cold type common cold, headache, nasosinusitis, phlegm-fluid retention cough and asthma, wind-cold-dampness arthralgia.
Stone lotus: sweet and flat; enters the lung, liver and kidney meridians. Lung moistening and cough relieving, and toxin removing and detumescence. Cough due to primary tuberculosis, tracheitis, sore throat.
Root of glossy privet: bitter and flat; enter the lung and liver meridians. Promoting qi circulation, promoting blood circulation, relieving cough and asthma, and eliminating turbid dampness. Mainly asthma and cough.
White flowers: light taste and cool; it enters liver and lung meridians. Diminishing inflammation, detoxicating and relieving cough. Main pneumonia, tracheitis, pulmonary tuberculosis hemoptysis, hepatitis.
Stink tree: bitter and pungent taste, warm; it enters lung and liver meridians. Cough with eyes, dispelling cold and relieving pain. Cough mainly.
Radix Platycodi: bitter and pungent taste, and flat; dispersing lung qi, eliminating phlegm, relieving sore throat, and expelling pus. Is mainly used for treating cough with excessive phlegm, sore throat, pulmonary abscess with pus, chest fullness and hypochondriac pain.
Green tangerine peel: bitter, pungent and warm; enter liver, gallbladder and stomach meridians. Liver soothing, qi breaking, food retention removing and stagnation eliminating effects. Can be used for treating chest and rib pain, acute mastitis, hernia pain, and food stagnation.
Lily: sweet and slightly cold in taste; enter heart and lung meridians. Nourishing yin, moistening lung, clearing away heart-fire and tranquillizing. Can be used for treating chronic cough due to yin deficiency, blood in phlegm, dysphoria, palpitation, and absentmindedness.
White atractylodes rhizome: bitter and sweet in taste and warm in temperature; enter spleen and stomach meridians. Invigorate the spleen, replenish qi, dry dampness, promote diuresis and stop sweating.
Licorice root: sweet and flat; it enters heart meridian, stomach meridian, spleen meridian and lung meridian. Has the effects of invigorating spleen, replenishing qi, relieving cough, eliminating phlegm, relieving spasm, relieving pain and harmonizing medicine property.
The Chinese medicinal composition takes the large tile and the stinky tree as monarch drugs, and both enter the lung channel to play roles of dispelling wind and cold, ventilating the lung and relieving cough; radix Platycodi has effects of dispersing lung qi, resolving phlegm, relieving sore throat, and expelling pus; shi Huan Lian and Laobai Hua can moisten lung and relieve cough, detoxify and detumescence; the glossy privet root and the glossy privet root are used together to strengthen the efficacy of the monarch drug in dispersing lung qi and relieving cough, and are used as ministerial drugs together. Atractylodis rhizoma has effects of invigorating spleen, invigorating qi, eliminating dampness, and promoting diuresis; pericarpium Citri Reticulatae viride has effects of dispersing stagnated liver qi, removing qi stagnation, and resolving food stagnation; lily has effects of nourishing yin, moistening lung, clearing heart fire and tranquillizing; the combination of the bighead atractylodes rhizome, the lily and the green tangerine peel can assist monarch drugs, ministerial drugs and enhance the curative effect, and are all adjuvant drugs. Licorice root, radix Glycyrrhizae Praeparata has the effects of invigorating spleen, replenishing qi, moistening lung, relieving cough, clearing away heat and toxic materials, relieving pain, alleviating drug properties, and harmonizing the drugs.
The prescription has the advantages of simple and convenient selection of medicines, mutual curative effect among the medicines and proper compatibility; mild, moist, not dry, not greasy, dispelling wind and cold, not helping heat and pathogen; has good curative effects of dispersing lung qi, eliminating phlegm, relieving cough and asthma. The recipe is suitable for cough caused by abnormal ascending and descending of qi of the lung due to various factors, such as cough caused by cold and heat and exogenous internal injury.
Drawings
The effect of each of the Chinese medicinal compositions on the antitussive effect of mice in FIG. 1.
The effect of each of the Chinese medicinal compositions on the effect of eliminating phlegm of the phenol red in mice is shown in figure 2.
Detailed Description
The present invention will be described in further detail with reference to specific examples in order to make the objects, technical solutions and advantages of the present invention more apparent, but it should not be construed that the scope of the present invention is limited to only the examples described below.
The "cough" as described herein may vary in symptoms due to the different etiologies.
Cough in traditional Chinese medicine is classified into exogenous cough, internal injury cough and cough due to lung fire. Wherein the exogenous cough comprises wind-cold cough, wind-heat cough and wind-dryness lung injury; cough due to internal injury is classified into cough due to lung qi deficiency and cough due to lung yin deficiency.
Symptoms of cough due to wind-cold are: the sick animals are aversion to cold, mao Nili, micro-trembling of the body, cool ears and nose, low weight of cough sound, clean and thin nasal discharge, light and moist mouth, thin and white tongue coating, no love of drinking water, clear and long urine, floating and tight pulse condition, heavy cough with cold and light cough with heat.
Symptoms of cough due to wind-heat are: the sick animals have the symptoms of aversion to air, cough, thick breath, dry mouth, hot body, loud and loud nose, yellow sticky color, hot expired air, thin and yellow tongue coating, thirst, preference for drinking water, red mouth color and superficial and rapid pulse.
The symptoms of wind dryness hurting the lung are: the animals suffering from the illness often have fever, slight aversion to wind and cold, stuffy nose and red throat, cough with little sputum, dry cough without sputum, choking with continuous sound, cough with hoarseness, dry nose and throat, sticky sputum, thirst and drink preference, dry skin, red and dry tongue with little coating, slightly rapid pulse or purple finger print.
Symptoms of cough due to qi deficiency of lung are anorexia, listlessness, emaciation, mao Jiao suspension, chronic cough with low cough sound, cough with sweat even when moving, sticky nasal discharge, pale and white mouth, soft tongue and slow and thin pulse.
Symptoms of cough due to lung yin deficiency are: the disease animals frequently suffer from dry cough, are clear and heavy in day and night, have little phlegm and dry body fluid, have low fever and no degeneration, have red tongue and little coating, and have thready and rapid pulse.
In the invention, the traditional Chinese medicine composition and the traditional Chinese medicine composition preparation for treating the livestock and poultry cough are suitable for the cough caused by abnormal qi movement of the lung caused by various factors, and can be suitable for all the cough.
The term "latency" as described herein: in the invention, the traditional Chinese medicine composition for treating the cough of the livestock and poultry is used for treating the cough symptom, and the longer the incubation period is or the cough is not caused, the better the effect is. In general, when an animal is infected with bacterial virus, it may exhibit symptoms similar to those of the cold in the early stage, and then typical cough symptoms such as cough with a sound, runny nose or thin nasal discharge, aversion to cold or aversion to wind, etc. The exogenous cough of the livestock and poultry clinically presents with acute onset and short disease course, and is often accompanied with exterior syndromes such as aversion to cold, fever and the like; cough due to internal injury is usually a chronic disease, repeated attacks, long disease course and other viscera disorder symptoms. Once the exterior syndrome of exogenous cough or internal injury cough of the animal is found, the animal needs to be treated in time. The medicament can prolong the incubation period of the sick animals or prevent the animals from cough in the cough treatment of the livestock and the poultry, which shows that the better the effect is.
Comparative example 1
The present example is a comparative example of a traditional Chinese medicine prescription for treating cough of livestock and poultry, which is different from example 1 in raw materials (in parts by weight), wherein the weight ratio of the prescription is as follows:
10 parts of large tile, 10 parts of stinky tree, 10 parts of clematis chinensis, 10 parts of white flowers, 10 parts of glossy privet roots, 5 parts of green tangerine peel, 5 parts of liquorice, 10 parts of platycodon grandiflorum, 5 parts of lily and 5 parts of bighead atractylodes rhizome.
Comparative example 2
The present embodiment is another comparative example of a traditional Chinese medicine prescription for treating cough of livestock and poultry, and the difference between the present embodiment and embodiment 1 is that the raw materials are changed into white front, wherein the weight ratio of the prescription is as follows:
20 parts of cynanchum glaucescens, 20 parts of stinky tree, 10 parts of clematis chinensis, 13 parts of white flowers, 15 parts of glossy privet roots, 8 parts of green tangerine peel, 5 parts of liquorice, 12 parts of platycodon grandiflorum, 8 parts of lily and 8 parts of bighead atractylodes rhizome.
The medicine properties and efficacy of the cynanchum atratum are as follows: pungent, bitter and slightly warm; enter lung meridian. It is indicated for cough with excessive phlegm due to qi-flowing downward and phlegm-resolving, lung qi-downward and cough and dyspnea-relieving.
Comparative example 3
The present embodiment is another comparative example of a traditional Chinese medicine prescription for treating livestock and poultry cough, and the difference between the present embodiment and embodiment 1 is that the raw materials, namely, the platycodon grandiflorum and the lily are replaced by perilla seed and coltsfoot flower, wherein the weight ratio of the prescription is as follows:
20 parts of large tile, 10 parts of stinky tree, 10 parts of clematis chinensis, 10 parts of white flowers, 10 parts of glossy privet roots, 8 parts of green tangerine peel, 5 parts of liquorice, 12 parts of perilla, 8 parts of coltsfoot flowers and 8 parts of bighead atractylodes rhizome.
The medicine property and efficacy of perilla are as follows: pungent and warm; enter lung and spleen meridians. It is suitable for common cold, aversion to cold, fever, cough, asthma, chest and abdominal distention, etc.
The medicine property and efficacy of coltsfoot flower are: pungent taste and warm nature; enter lung meridian. Has effects of relieving cough, descending qi, moistening lung, and eliminating phlegm. Can be used for treating cough, asthma, consumptive lung disease, and cough with hematemesis.
Comparative example 4
The present embodiment is another comparative example of a traditional Chinese medicine prescription for treating cough of livestock and poultry, the difference between the present embodiment and embodiment 1 is that the raw materials are that green tangerine peel is replaced by cortex phellodendri, and no stink peppery tree, white flower and glossy privet root are added, wherein the weight ratio of the prescription is as follows:
20 parts of large tile, 10 parts of stone string lotus, 8 parts of amur corktree bark, 5 parts of liquorice, 12 parts of platycodon grandiflorum, 8 parts of lily and 8 parts of bighead atractylodes rhizome.
The property and efficacy of phellodendron are: bitter taste and cold nature; kidney, bladder and large intestine channels; has effects of clearing heat, eliminating dampness, purging pathogenic fire and removing toxic substances.
Comparative example 5
The present embodiment is another comparative example of a traditional Chinese medicine prescription for treating livestock and poultry cough, and the difference between the present embodiment and embodiment 1 is that the raw materials are that the bighead atractylodes rhizome is replaced by magnolia officinalis, and no shi-buling, green tangerine peel and liquorice are added, wherein the weight ratio of the prescription is as follows:
20 parts of large tile, 20 parts of stinky tree, 10 parts of white flower, 10 parts of glossy privet root, 10 parts of platycodon grandiflorum, 8 parts of lily and 6 parts of magnolia officinalis.
The medicinal properties and efficacy of Magnolia officinalis are: bitter and pungent taste, warm; enter spleen, stomach, lung and large intestine meridians. Has effects of eliminating dampness, promoting qi circulation, resolving food stagnation, eliminating phlegm and relieving asthma.
Example 1
The embodiment is an embodiment of a traditional Chinese medicine prescription for treating livestock and poultry cough, wherein the weight ratio of the prescription is as follows:
20 parts of large tile, 20 parts of stinky tree, 10 parts of clematis chinensis, 10 parts of white flowers, 10 parts of glossy privet roots, 8 parts of green tangerine peel, 6 parts of liquorice, 12 parts of platycodon grandiflorum, 8 parts of lily and 8 parts of bighead atractylodes rhizome.
Example 2
The embodiment is another embodiment of a traditional Chinese medicine prescription for treating livestock and poultry cough, wherein the weight ratio of the prescription is as follows:
23 parts of large tile, 23 parts of stinky tree, 10 parts of clematis chinensis, 13 parts of white flowers, 15 parts of glossy privet roots, 8 parts of green tangerine peel, 6 parts of liquorice, 10 parts of platycodon grandiflorum, 10 parts of lily and 6 parts of bighead atractylodes rhizome.
Example 3
The embodiment is another embodiment of a traditional Chinese medicine prescription for treating livestock and poultry cough, wherein the weight ratio of the prescription is as follows:
25 parts of large tile, 17 parts of stinky tree, 13 parts of clematis chinensis, 13 parts of white flowers, 10 parts of glossy privet roots, 6 parts of green tangerine peel, 5 parts of liquorice, 15 parts of platycodon grandiflorum, 6 parts of lily and 10 parts of bighead atractylodes rhizome.
Example 4
The embodiment is another embodiment of a traditional Chinese medicine prescription for treating livestock and poultry cough, wherein the weight ratio of the prescription is as follows:
15 parts of large tile, 25 parts of stinky tree, 13 parts of clematis chinensis, 9 parts of white flowers, 13 parts of glossy privet roots, 10 parts of green tangerine peel, 3 parts of liquorice, 9 parts of platycodon grandiflorum, 10 parts of lily and 6 parts of bighead atractylodes rhizome.
Example 5
The embodiment is another embodiment of a traditional Chinese medicine prescription for treating livestock and poultry cough, wherein the weight ratio of the prescription is as follows:
17 parts of large tile, 23 parts of stinky tree, 15 parts of clematis chinensis, 10 parts of white flowers, 10 parts of glossy privet roots, 6 parts of green tangerine peel, 7 parts of liquorice, 14 parts of platycodon grandiflorum, 6 parts of lily and 9 parts of bighead atractylodes rhizome.
Example 6
The embodiment is another embodiment of a traditional Chinese medicine prescription for treating livestock and poultry cough, wherein the weight ratio of the prescription is as follows:
23 parts of large tile, 23 parts of stinky tree, 15 parts of clematis chinensis, 9 parts of white flowers, 9 parts of glossy privet roots, 10 parts of green tangerine peel, 5 parts of liquorice, 15 parts of platycodon grandiflorum, 9 parts of lily and 6 parts of bighead atractylodes rhizome.
Example 7
The embodiment is another embodiment of a traditional Chinese medicine prescription for treating livestock and poultry cough, wherein the weight ratio of the prescription is as follows:
15 parts of large tile, 17 parts of stinky tree, 9 parts of clematis chinensis, 13 parts of white flowers, 13 parts of glossy privet roots, 9 parts of green tangerine peel, 5 parts of liquorice, 10 parts of platycodon grandiflorum, 9 parts of lily and 6 parts of bighead atractylodes rhizome.
EXAMPLE 8 preparation of Chinese medicinal composition preparation
The traditional Chinese medicine composition comprises the following components: 15 parts of large tile, 17 parts of stinky tree, 9 parts of clematis chinensis, 13 parts of white flowers, 13 parts of glossy privet roots, 9 parts of green tangerine peel, 5 parts of liquorice, 10 parts of platycodon grandiflorum, 9 parts of lily and 6 parts of bighead atractylodes rhizome.
The preparation for preparing the traditional Chinese medicine composition comprises the following preparation methods:
firstly, weighing the raw medicinal materials according to the parts by weight, and cutting into sections.
Secondly, mixing the crude drugs treated in the first step into an extraction tank, adding water with the weight being 9 times of the total weight of the crude drugs, soaking for 1h, and then decocting with slow fire for 1.5h after boiling;
thirdly, filtering the traditional Chinese medicine in the second step, and adding water which is 9 times of the total weight of the medicinal materials into filter residues for decoction for 1h;
fourth, filtering the traditional Chinese medicine in the third step, and adding water which is 8 times of the total weight of the medicinal materials to decoct for 1h;
and fifthly, merging the three decocted liquid medicines, overnight, centrifuging to obtain supernatant, concentrating the liquid medicine to obtain 1g/mL of crude drug, sterilizing to prepare an oral liquid finished product, and refrigerating at 5 ℃ for later use.
EXAMPLE 9 study of the antitussive effects of the formulations of the groups on mice
Test animals: the strain KM mice, clean grade, male, weight 20-22 g, beijing vitamin Toril Hua laboratory animal technology Co.
Test reagent: ammonia, analytical grade, lot number 191219, the company of the sciences, the company of the ridge. The test requires preparation of 25% strength ammonia. Codeine phosphate, lot 6190583, pharmaceutical manufacturing, australia.
After the mice were adaptively raised for a period of time, screening before experiments was performed, putting the mice into a 1L beaker, spraying concentrated ammonia water quantitatively and at constant pressure into the beaker for 15s by using a sprayer, taking out the mice, observing the behavior of the mice, and simultaneously opening the mouth while cough appears as abdominal muscle contraction, and recording the incubation period from the start of spraying to the occurrence of cough and the number of times of cough within 2min, if the mice do not cough within 2min, discarding the mice. 140 qualified mice are selected.
According to the random grouping principle, the mice are divided into 14 cages, wherein each cage is 10, namely, a blank group, a codeine phosphate group, test groups 1-7 and control groups 1-5, and the mice in each group eat drinking water freely. The blank group is fed with 10mL/kg physiological saline; the codeine phosphate group is fed with 50mg/kg codeine phosphate; the test groups 1 to 7 are respectively and intragastrically administered with 10mL/kg of the traditional Chinese medicine oral liquid medicines prepared in the examples 1 to 7, and the preparation method of the oral liquid is shown in the example 8; the control groups 1-5 were respectively administered by gavage for 3 days with 10mL/kg of the oral liquid medicine prepared in comparative examples 1-5. After the last 2 hours of drug infusion, the cough latency of each group of mice, and the number of cough times within 2 minutes were recorded according to the concentrated ammonia water spray method, and data analysis was performed, and test results are shown in table 1.
Table 1 influence of the formulations of the groups on the antitussive effect in mice (x.+ -. S)
Test results show that compared with a blank group, the incubation period of mice in the test group is prolonged to different degrees; the times of cough of mice in the test group are reduced to different degrees within 2min, which indicates that the Chinese medicinal preparation has better inhibition effect on the cough of mice induced by an ammonia water method, and has obvious dose-effect relationship (see figure 1).
The traditional Chinese medicine preparation disclosed by the invention can obviously prolong the incubation period of cough of mice and reduce the times of cough of the mice, and has an obvious cough relieving effect.
EXAMPLE 10 investigation of the effect of the formulations of the groups on the reduction of phlegm in phenol Red in mice
Test animals: the strain KM mice, clean grade, male, weight 20-22 g, beijing vitamin Toril Hua laboratory animal technology Co.
Test reagent: phenol red, lot 2009142, the company of the sciences, the company of the ridge of the sciences.
The test adopts a phenol red indicator method to measure the phlegm eliminating effect of the traditional Chinese medicine composition, after the indicator phenol red is injected from the abdominal cavity of a mouse and absorbed by the abdominal cavity, the indicator phenol red can be secreted into the airway by the bronchial mucous gland partially, and the medicament with the phlegm eliminating effect can increase the secretion of the bronchus and increase the phenol discharged from the mucosa of the respiratory tract simultaneously, so that the phlegm eliminating effect can be observed from the influence of the medicament on the discharge amount of the phenol red in the trachea. Phenol red is red in alkaline solution, and the liquid washed out from the channel is measured by colorimetry (spectrophotometer) to obtain the phlegm eliminating effect of the medicine.
100 mice are taken and divided into 10 cages according to a random grouping principle, wherein each cage is 10, namely, a blank group, a codeine phosphate group, test groups 1-4 and control groups 1-4. The blank group is fed with 10mL/kg physiological saline; the codeine phosphate group is fed with 50mg/kg codeine phosphate; the test groups 1 to 4 were respectively given 10mL/kg of the Chinese medicinal oral liquid medicines prepared in examples 1 to 3 and example 6 by stomach irrigation; the comparative groups 1 to 4 were respectively administered by stomach infusion with 10mL/kg of the Chinese medicinal oral liquid prepared in comparative examples 1 to 3 and comparative example 5, and the oral liquids of the Chinese medicinal compositions of examples 1 to 7 were prepared as described in example 8 for 5 days. Fasted for 12h before test, and after 30min of final drug infusion, 0.8mL of 0.25% phenol red physiological saline is injected into each mouse intraperitoneally, and after 30min, the mouse is sacrificed, a section of trachea from the thyroid cartilage to the tracheal branch is dissected and cut off, and 5% NaCO is used 3 The solution was repeatedly rinsed as a rinse solution for 3 times, the 3 rinse solutions were combined, centrifuged for 5min (3000 r/min), absorbance was measured colorimetrically at 546nm wavelength, and data analysis was performed, and the test results are shown in Table 2.
Table 2 influence of the formulations of the groups on the expectorant effect (x.+ -. S) of phenol red in mice
The test results show that compared with the blank group, the tracheal phenol red excretion amounts of mice in the test group are increased to different degrees, which indicates that the traditional Chinese medicine preparation has better promotion effect on the tracheal phenol red excretion amounts and has obvious dose-effect relationship (see figure 2).
The traditional Chinese medicine preparation disclosed by the invention can obviously promote the excretion of the tracheal phenol red of mice, and has an obvious phlegm eliminating effect.
Claims (7)
1. The traditional Chinese medicine composition for treating the livestock and poultry cough is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 15-25 parts of large tile, 15-25 parts of stinky tree, 9-15 parts of stone string lotus, 9-15 parts of white flowers, 9-15 parts of glossy privet roots, 5-10 parts of green tangerine peel, 3-9 parts of liquorice, 9-15 parts of platycodon grandiflorum, 5-10 parts of lily and 5-10 parts of bighead atractylodes rhizome.
2. The traditional Chinese medicine composition for treating livestock and poultry cough according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials, by weight, 18-23 parts of large tile, 18-23 parts of stinky peppery tree, 13-15 parts of clematis chinensis, 9-10 parts of white flower, 9-10 parts of glossy privet root, 8-10 parts of green tangerine peel, 3-5 parts of liquorice, 14-15 parts of platycodon grandiflorum, 8-10 parts of lily and 6-8 parts of bighead atractylodes rhizome.
3. The traditional Chinese medicine composition for treating livestock and poultry cough according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight, 23 parts of large tile, 23 parts of peppery tree, 15 parts of clematis chinensis, 9 parts of white flower, 9 parts of glossy privet root, 10 parts of green tangerine peel, 5 parts of liquorice, 15 parts of platycodon grandiflorum, 9 parts of lily and 6 parts of bighead atractylodes rhizome.
4. A formulation of a traditional Chinese medicine composition for treating livestock and poultry cough as claimed in any one of claims 1 to 3, wherein the pharmaceutical formulation comprises the pharmaceutical composition for treating livestock and poultry cough and pharmaceutically acceptable auxiliary materials.
5. The formulation of claim 4, wherein the formulation of the traditional Chinese medicine composition is selected from one or more of a cream, a pill, a pellet, a decoction, a granule, a capsule, a powder and a tablet.
6. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials, by weight, 15-25 parts of large-block tile, 15-25 parts of stinky spicy tree, 9-15 parts of clematis chinensis, 9-15 parts of white flowers, 9-15 parts of glossy privet roots, 5-10 parts of green tangerine peel, 3-9 parts of liquorice, 9-15 parts of platycodon grandiflorum, 5-10 parts of lily and 5-10 parts of bighead atractylodes rhizome; the method comprises the following steps:
s01, weighing the raw materials according to the parts by weight, and cutting into segments;
s02, mixing the processed raw materials into an extraction tank, adding water with the weight which is 8-12 times of the total weight of the raw materials, firstly soaking for 0.5-1 h, and then decocting with slow fire for 1-2 h after boiling;
s03, filtering the traditional Chinese medicines, and adding water which is 7-10 times of the total weight of the medicinal materials into filter residues for decoction for 1-2 h;
s04, continuously filtering the traditional Chinese medicines, and adding water which is 6-8 times of the total weight of the medicinal materials to decoct for 1-2 h;
s05, merging the three decocted liquid medicines, overnight, centrifuging to obtain supernatant, concentrating the liquid medicine until the crude drug amount is 1-3 g/mL, sterilizing to obtain a finished product, and refrigerating at 2-8 ℃ for later use.
7. The application of the traditional Chinese medicine composition in preparing the medicine for treating the livestock and poultry cough is characterized in that the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight, 15-25 parts of large tile, 15-25 parts of stinky tree, 9-15 parts of shi-chuan, 9-15 parts of white flower, 9-15 parts of glossy privet root, 5-10 parts of green tangerine peel, 3-9 parts of liquorice, 9-15 parts of platycodon grandiflorum, 5-10 parts of lily and 5-10 parts of bighead atractylodes rhizome.
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| CN106692829A (en) * | 2016-12-26 | 2017-05-24 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine composition for treating cough of livestock and poultry and preparation method thereof |
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| CN106692829A (en) * | 2016-12-26 | 2017-05-24 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine composition for treating cough of livestock and poultry and preparation method thereof |
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