CN115006496B - Chinese herbal medicine composition for treating pneumonia of foxes, raccoon dogs and martens - Google Patents
Chinese herbal medicine composition for treating pneumonia of foxes, raccoon dogs and martens Download PDFInfo
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- CN115006496B CN115006496B CN202210657806.2A CN202210657806A CN115006496B CN 115006496 B CN115006496 B CN 115006496B CN 202210657806 A CN202210657806 A CN 202210657806A CN 115006496 B CN115006496 B CN 115006496B
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Abstract
The invention discloses a Chinese herbal medicine composition for treating pneumonia of foxes, raccoon dogs and martens, and belongs to the technical field of veterinary medicines. The invention combines herba andrographitis, yellow flower mother, reed rhizome, snakegourd fruit, cordate houttuynia, dangshen and liquorice for use, and achieves the aim of treating pneumonia of fur animals such as foxes, raccoon dogs, martens and the like through bacteriostasis, anti-inflammation, lung diffusing, cough relieving and asthma relieving; the traditional Chinese medicine has good treatment effect, high cure rate, difficult recurrence and no toxic or side effect; the preparation method is simple, convenient to use, high in economic benefit and suitable for large-area popularization and application.
Description
Technical Field
The invention relates to the technical field of veterinary medicines, in particular to a Chinese herbal medicine composition for treating pneumonia of foxes, raccoon dogs and martens.
Background
Along with the improvement of the living standard of people, the fur demand of fur animals such as foxes, raccoons, martens and the like is increased, and the fur animal breeding industry such as foxes, raccoons, martens and the like is rapidly developed; however, because of common cold, unclean air, poor ventilation and lack of vitamins in the organism, respiratory tract infection and organism resistance of fur-bearing animals such as foxes, raccoon dogs and martens are reduced, so that microorganisms (mainly pseudomonas aeruginosa, escherichia coli pneumoniae, klebsiella and pasteurella multocida) in the respiratory tract or in vitro are in a period of incubation period, the disease state is developed, the foxes, raccoon dogs and martens are affected by bacteria, and the pneumonia caused by the infection of the foxes, raccoon dogs and martens is induced. The pneumonia of foxes, raccoon dogs and marten fur animals has the characteristics of quick morbidity, quick infection and high mortality rate, and brings great economic loss to raisers. The domestication time of foxes, raccoons and marten fur animals is short, certain wild property is still maintained, the foxes, raccoons and marten fur animals are not easy to access, and the treatment of diseases is difficult; if common antibiotics are adopted for treatment, the problems of low cure rate, drug resistance generated by pathogens and continuously enhanced drug resistance exist. The Chinese herbal medicine has the characteristics of nature, no toxic or side effect, no chemical drug residue, difficult generation of drug resistance and the like, and can effectively prevent and treat the pneumonia of the foxes, the raccoon dogs and the martens by clinically adopting the Chinese herbal medicine with the functions of inhibiting bacteria, ventilating the lung, relieving cough and calming asthma according to the pathogenesis of the pneumonia of the foxes, the raccoon dogs and the martens. At present, few special Chinese herbal medicines are used for preventing and treating pneumonia of foxes, raccoons and martens, and some medicines have poor curative effect in practice, low cure rate, long treatment course and high cost.
Therefore, the problem to be solved by the person skilled in the art is to provide a Chinese herbal medicine composition for treating the pneumonia of foxes, raccoon dogs and martens.
Disclosure of Invention
In view of the above, the invention provides a Chinese herbal medicine composition for treating pneumonia of foxes, raccoon dogs and martens, which achieves the aim of treating pneumonia by inhibiting bacteria, diminishing inflammation, ventilating lung, relieving cough and asthma; has good treatment effect, high cure rate, difficult recurrence, no toxic or side effect and simple and quick preparation method.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a Chinese herbal medicine composition for treating pneumonia of foxes, raccoon dogs and martens is prepared from the following raw materials in parts by weight: 3-5 parts of common andrographis herb, 3-5 parts of yellow flower mother, 3-5 parts of reed rhizome, 2-4 parts of snakegourd fruit, 2-4 parts of heartleaf houttuynia herb, 2-4 parts of pilose asiabell root and 1-2 parts of liquorice.
Andrographis paniculata efficacy: herba Andrographitis, herba Hedyotidis Diffusae, herba Lysimachiae Foenumgraeci, etc. Neutral nature and bitter taste, enter lung, large intestine, liver and spleen meridians. The whole herb has hemostatic effect; the herb decoction has good antibacterial effect on staphylococcus aureus, pseudomonas aeruginosa and pneumococcus. Has effects of clearing heat and detoxicating, diminishing inflammation, detumescence and relieving pain, inducing diuresis for treating stranguria, protecting liver and promoting bile flow. Can be used for treating common cold, fever, pneumonia, sore throat, acute and chronic bronchitis, acute gastroenteritis, etc.
Efficacy of Hemerocallis citrina baroni: herba Violae, flos Hemerocallis, etc. Cool in nature and sweet in flavor, it enters heart, lung, large and small intestine meridians. 50% of the decoction has strong antibacterial effect on shigella dysenteriae and staphylococcus aureus; has inhibiting effect on typhoid fever, dysentery, coliform, and bacillus and pneumococcus. Has effects of clearing heat, promoting diuresis, promoting blood circulation and expelling pus. Can be used for treating pneumonia, influenza, common cold, dysentery, enteritis, etc.
Reed rhizome efficacy: reed rhizome, reed root, etc. It is cold in nature and sweet in flavor, enters lung and stomach meridians. The rootstock contains a large amount of vitamins B1, B2, C and 5% protein, 1% fat, 51% carbohydrate, 0.1% asparagine. Contains amino acid, fatty acid, sterol, tocopherol, polyphenol, 2, 5-dimethoxy-p-benzoquinone, p-hydroxybenzaldehyde, vanillic acid, ferulic acid, etc. Has effects of clearing heat, promoting salivation, relieving restlessness, relieving vomiting, and promoting urination. Can be used for treating cough due to lung heat, lung abscess, vomiting pus, pyretic disease, polydipsia, and emesis due to stomach heat.
Fructus trichosanthis effect: fructus Trichosanthis, and rhizoma paridis. Sweet in flavor and cold in nature, it belongs to the meridians of lung, stomach and large intestine. Comprises saponin, organic acid and its salt, resin, fatty oil, pigment, triterpenoid saponin, lauric acid, myristic acid, etc. The snakegourd fruit has a certain inhibiting effect on pneumococci, influenza bacillus, escherichia coli, shigella sonnei, proteus, staphylococcus and the like in vitro. Has effects in relieving fever, quenching thirst, promoting urination, relieving cough, and eliminating phlegm. Can be used for treating pulmonary abscess and acute appendicitis.
Efficacy of houttuynia cordata: herba Houttuyniae, radix et rhizoma Rhei, herba Potamogetis crispae, herba Houttuyniae, etc. Pungent in flavor, cold in nature and cool in nature, enters liver and gallbladder meridians. Contains volatile oil, decanoyl acetaldehyde houttuynin and other components. Has antibacterial effect on pathogenic bacillus, coccus, influenza virus, etc. Has effects of clearing heat and detoxicating, promoting urination and removing dampness, invigorating stomach and resolving food stagnation. Can be used for treating pneumonia, upper airway infection, bronchitis, and chronic tracheitis.
Radix codonopsis efficacy: radix Saposhnikoviae and radix Codonopsis Lanceolatae, and radix Codonopsis Lanceolatae. Neutral in nature and sweet in taste, enter spleen and lung meridians. Has effects of invigorating qi, promoting salivation, and nourishing blood. Can be used for treating spleen and lung weakness, short breath, palpitation, loose stool, asthma, cough, internal heat, and diabetes.
Licorice efficacy: liquorice aliases Meicao, miao, lao, sweet grass, etc. Neutral nature and sweet taste, enter spleen, stomach and lung meridians. Comprises glycyrrhizic acid, glycyrrhizin, licoflavone, and Glycyrrhrizae radix polysaccharide, and has antiulcer and macrophage phagocytic function regulating effects. Glycyrrhizic acid is a natural antidote and can be used for enhancing immunity, maintaining water and salt metabolism balance, etc. Has effects of invigorating spleen, replenishing qi, clearing heat, detoxicating, relieving spasm, relieving pain, and harmonizing various drugs. Can be used for treating weakness of spleen and stomach, asthenia, carbuncle, skin sore, and toxic materials, and for relieving virulence.
The invention combines herba andrographitis, yellow flower mother, reed rhizome, snakegourd fruit, cordate houttuynia, dangshen and liquorice for use, and achieves the aim of treating pneumonia by inhibiting bacteria, ventilating lung, relieving cough and asthma; has good treatment effect, high cure rate, difficult recurrence and no toxic and side effects.
Further, the Chinese herbal medicine composition for treating the pneumonia of foxes, raccoon dogs and martens is prepared from the following raw materials in parts by weight: 3 parts of common andrographis herb, 3 parts of yellow flower mother, 4 parts of reed rhizome, 2 parts of snakegourd fruit, 3 parts of heartleaf houttuynia herb, 3 parts of pilose asiabell root and 2 parts of liquorice.
Compared with the prior art, the invention discloses a Chinese herbal medicine composition for treating the pneumonia of foxes, raccoon dogs and martens, which is prepared from common andrographis herb, yellow flower mother, reed rhizome, snakegourd fruit, cordate houttuynia, dangshen and liquorice, and achieves the aim of treating the pneumonia of foxes, raccoon dogs and martens by bacteriostasis, lung diffusing, cough relieving and asthma relieving; the traditional Chinese medicine has good treatment effect, high cure rate, difficult recurrence and no toxic or side effect; the preparation method is simple, convenient to use, high in economic benefit and suitable for large-area popularization and application.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A Chinese herbal medicine composition for treating pneumonia of foxes, raccoon dogs and martens is composed of the following raw materials: 150g of common andrographis herb, 150g of yellow flower mother, 200g of reed rhizome, 100g of snakegourd fruit, 150g of heartleaf houttuynia herb, 150g of pilose asiabell root and 100g of liquorice, and the specific preparation method comprises the following steps:
(1) Weighing the raw materials according to the weight;
(2) Pulverizing the above raw materials into coarse powder respectively;
(3) Soaking the coarse powder of the seven Chinese herbal medicines in 8000mL of water for 1 hour, decocting, boiling water, and decocting with slow fire for 30 minutes; filtering to obtain primary filtrate, decocting the residue twice with 6000mL water for 20min, and filtering to obtain secondary and tertiary filtrates; combining the three filtrates, and concentrating to about 900mL;
(4) Adding 0.05% sodium benzoate serving as a preservative into the concentrated solution, adding water to 1000mL, stirring uniformly, filtering, filling and sterilizing to obtain the Chinese herbal medicine composition liquid, wherein each mL contains 1g (1 g/mL) of crude drug.
When the Chinese herbal medicine composition for preventing and treating the pneumonia of foxes, raccoon dogs and martens is applied, the Chinese herbal medicine composition is added according to the weight of 0.5%, 1% and 2% of the weight of daily ration, and the decoction of the formula is uniformly mixed in the daily ration (liquid food and puffed feed) within the first half hour of feeding, and the test lasts for 6-7 days for 2 times a day.
The Chinese herbal medicine composition for preventing and treating the pneumonia of foxes, raccoon dogs and martens is used for carrying out related experiments, and is specifically as follows:
test example 1:
drug sensitivity test on pathogenic bacteria such as Pseudomonas aeruginosa, escherichia coli pneumonia, klebsiella pneumoniae and Pasteurella multocida for pneumonia of foxes, raccoon dogs and martens: selecting clinical cases of the disease of the foxes, the raccoon dogs and the martens of pneumonia, separating and identifying pathogenic bacteria of the foxes, the raccoon dogs and the martens of pneumonia such as pseudomonas aeruginosa, escherichia coli, klebsiella pneumoniae and pasteurella multocida, weighing a certain amount of the Chinese herbal medicine composition for preventing and treating the foxes, the raccoon dogs and the martens of pneumonia, preparing the liquid with 1g of crude drug in each mL, sterilizing, packaging and preserving at 4 ℃ for later use. The pathogenic bacteria such as Pseudomonas aeruginosa, escherichia coli pneumonia, klebsiella pneumoniae and Pasteurella multocida which are clinically separated are respectively inoculated on a blood agar culture plate, cultured for 18 hours at 37 ℃, typical colonies are respectively selected from the blood agar culture plates of the four pathogenic bacteria and respectively inoculated on 5mL of nutrient broth, cultured for 18 hours at 37 ℃, and then 0.5 McO standard turbidimetric tube is used for turbidimetry, and the bacterial solution is diluted to 10 by the nutrient broth 5 CFU/mL was used as bacterial suspension to be tested.
Drug sensitivity test: taking the bacterial suspension to be tested, uniformly and densely coating the bacterial suspension to be tested (1 mL) on the surface of a culture medium of a plate (with the diameter of 90 mm) by using a sterilized cotton swab, performing a drug-sensitive test by adopting an oxford cup method (a round small tube with the inner diameter of 6mm, the outer diameter of 8mm and the height of 10 mm), adding the Chinese herbal medicine composition liquid (1 g/mL) for preventing and treating the pneumonia of foxes, raccoon dogs and martens, which is suitable for filling but not overflowing out of a hole, selecting two known antibiotics with good effect on the pneumonia of the foxes, raccoon dogs and martens, such as a drug-sensitive test of enrofloxacin (1 mug/mL) and ceftiofur sodium (1 mug/mL), placing the two antibiotics and the drug-sensitive test in a 37 ℃ constant-temperature incubator for culturing for 24 hours, measuring the diameter of a bacteriostasis ring, and repeating the drug-sensitive test of each medicine for three times. Determination criteria: according to the standards of traditional Chinese medicine pharmacology and drug sensitivity test standardization of 2005 edition of American clinical laboratory standardization institute, the antibacterial diameter is more than or equal to 20mm and is extremely sensitive; the antibacterial diameter of 20mm is more than or equal to 15mm, and the antibacterial diameter is high-sensitivity; 15mm antibacterial diameter is equal to or more than 10mm, and is neutral; less than 10mm is hypoallergenic.
The Chinese herbal medicine composition for preventing and treating the pneumonia of foxes, raccoon dogs and martens has the drug sensitivity test results shown in table 1.
Table 1 results of drug sensitivity test of Chinese herbal medicine composition liquid (1 g/mL) on pneumonia of foxes, raccoon dogs and martens
Table 1 shows that the Chinese herbal medicine composition is highly sensitive to Pseudomonas aeruginosa, escherichia coli pneumonia and Klebsiella pneumoniae and extremely sensitive to Pasteurella multocida, and the antibacterial diameters of the Chinese herbal medicine composition are respectively 19.4, 19.5, 19.8 and 20.2mm. Enrofloxacin and ceftiofur sodium are highly sensitive to pseudomonas aeruginosa, escherichia coli pneumonia, klebsiella pneumoniae and pasteurella multocida. The drug sensitivity test shows that the Chinese herbal medicine composition for treating the fox, raccoon dog and marten pneumonia has the most sensitive inhibiting effects on pseudomonas aeruginosa, escherichia coli, klebsiella pneumoniae and pasteurella multocida, and the enrofloxacin is inferior and the ceftiofur sodium is inferior. The result shows that the Chinese herbal medicine composition is the first choice in the practice of treating the pneumonia of foxes, raccoon dogs and martens.
Test example 2 test of efficacy of the pneumonia of artificially infected foxes, raccoon dogs and martens
Taking mink as an example, taking a curative effect test of artificially infecting mink pneumonia by using bacillus pyocyaneus bacterial liquid which is a main pathogen clinically separated from the pneumonia as an example: 42 minks at 65 days of age were randomly divided into 6 groups of 7, each, and the grouping and treatment methods are shown in Table 2. Except for the healthy control group, 1mL of sterilized normal saline was injected, and each of the other groups was injected with Pseudomonas aeruginosa liquid (3.10) 6 individual/mL) 1mL, after the test mink (except the healthy control group) is subjected to toxin attack for 48 hours, the typical symptoms of pneumonia appear, the administration of the drug according to the dose shown in table 2 is started, the drug concentration is 1g/mL, 7d is used for the continuous use, the clinical change after the administration is observed, and the clinical symptoms and the death number of each group of mink are recorded every day. The experimental results are shown in Table 3.
Table 2 test animal grouping and treatment method
| Grouping | Quantity (only) | Addition method |
| High dosage group of Chinese herbal medicine composition | 7 | Infection, adding Chinese herbal medicine composition into mink daily ration according to 2% |
| Dosage group in Chinese herbal medicine composition | 7 | 1% of Chinese herbal medicine composition is added into daily ration of mink for infection |
| Chinese herbal medicine composition low dose group | 7 | Infection and mink ration herbal medicine composition with concentration of 0.5% |
| Enrofloxacin treatment group | 7 | 1.5kg of water is added into 0.5g of medicine for infection |
| Infection control group | 7 | Infection, not administered |
| Healthy control group | 7 | No infection and no administration of medicine |
Table 3 treatment results of artificial infection test of fox, raccoon dog and marten pneumonia
| Group of | Number of deaths (only) | Mortality rate of | Effective rate of | Cure rate |
| High dosage group of Chinese herbal medicine composition | 0 | 0 | 100％ | 100％ |
| Dosage group in Chinese herbal medicine composition | 1 | 14.3％ | 85.7％ | 85.7％ |
| Chinese herbal medicine composition low dose group | 2 | 28.6％ | 71.4％ | 71.4％ |
| Enrofloxacin treatment group | 2 | 28.6％ | 71.4％ | 71.4％ |
| Infection control group | 6 | 85.7％ | ||
| Healthy control group | 0 | 0 |
As can be seen from table 3, the cure rates of the high, medium and low dose groups of the herbal composition were very different from those of the infection control group (P < 0.01); the high and medium dosage groups of the Chinese herbal medicine composition have obvious difference in cure rate (P < 0.05) compared with enrofloxacin; the cure rate of the low dose group was not significantly different compared to enrofloxacin (P > 0.05).
Test example 3 test of curative effect of naturally infecting foxes, raccoon dogs and martens pneumonia
The natural onset mink (taking mink pneumonia as an example to count onset cases, the pathogenesis is pseudomonas aeruginosa) is respectively provided by farmers in Changli county, leting county, funing county in Hebei province, and finally the diagnosis is finished according to clinical symptoms, section change, animal inoculation test and laboratory examination results. Taking the infected mink groups as test groups, and taking reference to a pneumonia test of artificially infected foxes, raccoons and martens for administration, wherein the daily ration of the infected minks is added with a Chinese herbal medicine composition (the medicine concentration is 1 g/mL) according to 2%, and the daily ration is added with the Chinese herbal medicine composition for 2 times a day, and the administration is 7d as a treatment course. And continuing to observe for 3-5 days after stopping the medicine, judging that the patient with the disappearance of clinical symptoms, ingestion and normal state recovery is cured, determining the prevention and treatment effect by combining the pathological section detection sampling detection result, and counting the cure rate. The treatment results are shown in Table 4.
Table 4 therapeutic effects of Chinese herbal composition on Natural infection pneumonia mink
By treating 620 minks with natural infection and onset of pseudomonas aeruginosa pneumonia, the Chinese herbal medicine composition for preventing and treating the pseudomonas aeruginosa pneumonia of the minks has remarkable treatment effect on the pseudomonas aeruginosa pneumonia of the developed minks, the average cure rate is 94.7%, symptoms generally disappear after 5-7d, normal feeding is recovered, and excrement is normal.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (2)
1. The Chinese herbal medicine composition for treating the pneumonia of foxes, raccoon dogs and martens is characterized by comprising the following raw materials in parts by weight: 3-5 parts of common andrographis herb, 3-5 parts of yellow flower mother, 3-5 parts of reed rhizome, 2-4 parts of snakegourd fruit, 2-4 parts of heartleaf houttuynia herb, 2-4 parts of pilose asiabell root and 1-2 parts of liquorice.
2. The Chinese herbal medicine composition for treating pneumonia of foxes, raccoon dogs and martens according to claim 1 is characterized by comprising the following raw materials in parts by weight: 3 parts of common andrographis herb, 3 parts of yellow flower mother, 4 parts of reed rhizome, 2 parts of snakegourd fruit, 3 parts of heartleaf houttuynia herb, 3 parts of pilose asiabell root and 2 parts of liquorice.
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| CN103495057A (en) * | 2013-09-30 | 2014-01-08 | 山东省动物疫病预防与控制中心 | Traditional Chinese medicine composition for treating pneumonia of fur-bearing animals |
| CN107753788A (en) * | 2017-12-01 | 2018-03-06 | 赖飞云 | A kind of herbal medicine for treating pig pneumonia |
| CN110302276A (en) * | 2019-07-12 | 2019-10-08 | 北京生泰尔科技股份有限公司 | It is a kind of for preventing and treating the Chinese medicine composition and preparation method thereof of chicken pneumonia |
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| CN103495057A (en) * | 2013-09-30 | 2014-01-08 | 山东省动物疫病预防与控制中心 | Traditional Chinese medicine composition for treating pneumonia of fur-bearing animals |
| CN107753788A (en) * | 2017-12-01 | 2018-03-06 | 赖飞云 | A kind of herbal medicine for treating pig pneumonia |
| CN110302276A (en) * | 2019-07-12 | 2019-10-08 | 北京生泰尔科技股份有限公司 | It is a kind of for preventing and treating the Chinese medicine composition and preparation method thereof of chicken pneumonia |
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