CN104491204A - Traditional Chinese medicine composition for preventing and treating bacterial and virus infection of livestock and poultry and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for preventing and treating bacterial and virus infection of livestock and poultry and preparation method of traditional Chinese medicine composition Download PDF

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CN104491204A
CN104491204A CN201410765336.7A CN201410765336A CN104491204A CN 104491204 A CN104491204 A CN 104491204A CN 201410765336 A CN201410765336 A CN 201410765336A CN 104491204 A CN104491204 A CN 104491204A
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徐建红
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ZUNYI CITY QIANTU ANIMAL HUSBANDRY Co Ltd
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ZUNYI CITY QIANTU ANIMAL HUSBANDRY Co Ltd
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating bacterial and virus infection of livestock and poultry. The traditional Chinese medicine composition comprises the following raw materials: astragalus membranaceus, goldthread root, cortex phellodendri, scutellaria baicalensis, gardenia jasminoides ellis, fructus forsythia, honeysuckle, viola, artemisia apiacea, indigowood root, cyrtomium fortune and liquorice. According to the traditional Chinese medicine composition, the defects that an existing medicine for preventing and treating the bacterial and virus infection of the livestock and poultry is high in toxic and side effects, and high in price, and a plurality of epidemic diseases cannot be simultaneously prevented and treated are overcome. The invention provides the traditional Chinese medicine composition for preventing and treating bacterial and virus infection of livestock and poultry and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has the advantages of simple preparation process, low production cost, small toxic and side effects, and low price; and a plurality of epidemic diseases can be simultaneously prevented and treated.

Description

Para-infectious Chinese medicine composition of a kind of control poultry bacterium and preparation method thereof
Technical field
The present invention relates to field of traditional Chinese veterinary, be specifically related to a kind of control para-infectious Chinese medicine composition of poultry bacterium and preparation method.
Background technology
Poultry communicate illness is caused by bacterial disease pathogenic microorganism and viral cause pathogeny imcrobe infection mostly, especially over the past two years, poultry are because being infected by bacteria or virus various disease, cause immunity of livestock decline, fertility performance reduction, even death, this brings serious harm to whole animal husbandry and the mankind.In current aquaculture for poultry because the treatment of bacterial disease pathogenic microorganism mainly adopts antibiotic, vaccine, chemical antiviral medicine are mainly relied on to the treatment of virus.Chemical antiviral medicine is as disabled in Western medicine such as ribavirin, amantadine, moroxydines, because chemical antiviral medicine in kill virus simultaneously, certain toxicity is also existed to the host cell of poultry, destroy the animal body of poultry, multiple acute and chronic poisoning can be produced to poultry when the drug level of body accumulation reaches a certain amount of; In addition, the ingredient of antibiotic and chemical antiviral medicine class is single, usually can only treat single disease, can not reach the effect of prevention and therapy while of various diseases.Antibiolics class and chemical antiviral medicine class expensive, add feeding cost to undoubtedly breeding enterprise and raiser.This urgent demand requires having antibacterium or antiviral Chinese herbal medicine screens.The existing Chinese herbal medicine class of China 12807 kinds, wherein vegetable Chinese herbal medicine has 11146 kinds, animal class 1581 kinds, mineral substance has 80 kinds, and modern pharmacology research shows, many Chinese herbal medicine and Multiple components thereof have the effect of good antibacterial poison, according to clinical practice and the pharmacological research of modern Chinese medicine, antiviral Chinese medicine is divided into two large classes, the Chinese herbal medicine of the direct deactivation of a kind of energy or suppression virus, and conventional has vinegar, Radix Scutellariae, Radix Isatidis, Herba Ephedrae, Rhizoma Atractylodis, Fructus Schisandrae Chinensis, Folium Mori, Herba Artemisiae Annuae, Herba Verbenae, Herba Violae, Radix Arnebiae (Radix Lithospermi), Rhizoma Cyperi, Spica Prunellae, Radix Trichosanthis, Radix Et Rhizoma Rhei, Radix Notoginseng, white portion, Fructus Forsythiae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae, Cortex Phellodendri, Rhizoma Coptidis, Herba Andrographis etc., two is reach antiviral Chinese medicine by inducement interferon or promotion immune function of human body, and conventional has Radix Ginseng, Poria, Radix Codonopsis, Radix Scutellariae, the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Polygonati, Radix Angelicae Sinensis, Ganoderma, the Radix Polygoni Multiflori, Fructus Lycii, Cordycepses etc., treat the Radix Isatidis of viral single medicinal material as antipyretic clinically, Cortex Phellodendri, the Radix Astragali, Rhizoma Coptidis, Flos Lonicerae, Fructus Forsythiae, Cacumen Securinegae Suffruticosaes etc., have effect unique, the advantages such as toxic and side effects is little, but it is single to there is single medicinal material Chinese medicine composition, the shortcomings such as curative effect is slow.Along with the development of animal husbandry, Animal diseases are increasing, and have not been single antibacterial or viral infection mostly, but various bacteria or virus mixed infection.In addition the compatibility of unreasonable, the clinical treatment medication of some plant's medications and the medication of feedstuff growth promotion is improper, and causes antibacterial or virus to create drug resistance in various degree to single medicinal material, causes therapeutic effect not good.The compound Chinese herb applied in antibacterial malicious disease is at present generally some classical side or Empirical formula, do not take into full account synergism between often kind of Chinese medicine and curative effect is unstable, therefore, need to infect that a kind of toxic and side effects of research and development is little in control poultry bacterium class, Chinese medicine composition that low price, stable curative effect and multiple sick epidemic disease are prevented and treated simultaneously.
Summary of the invention
The technical problem to be solved in the present invention is for the shortcoming that existing toxic and side effects is strong, expensive, curative effect is unstable, multiple sick epidemic disease can not be prevented and treated simultaneously, a kind of control para-infectious Chinese medicine composition of poultry bacterium and preparation method are provided, this Chinese medicine composition has that toxic and side effects is little, low price, stable curative effect and multiple sick epidemic disease can prevention and therapy be a little simultaneously.
In order to solve the problems of the technologies described above, the invention provides following technical scheme: the para-infectious Chinese medicine composition of control poultry bacterium, is made up of major ingredient and adjuvant; Major ingredient raw material and its mass fraction ratio are: Radix Astragali 50-100 part, Rhizoma Coptidis 50-100 part, Cortex Phellodendri 50-100 part, Radix Scutellariae 100-200 part, Fructus Gardeniae 50-100 part, Fructus Forsythiae 100-150 part, Flos Lonicerae 50-100 part, Herba Violae 100-150 part, Herba Artemisiae Annuae 100-150 part, Radix Isatidis 100-200 part, Rhizoma Osmundae 100-150 part, Radix Glycyrrhizae 50-100 part.
Adopt the para-infectious Chinese medicine composition of control poultry bacterium of technical solution of the present invention, be made up of major ingredient and adjuvant, record according to " Chinese medicine voluminous dictionary ", " Chinese Pharmacopoeia ", " herbal classic meets source ", the Radix Astragali of major ingredient raw material: sweet, tepor.Return lung, spleen channel; Tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promotes the production of body fluid and nourishes blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, hemiplegia, and arthralgia pain is numb, and carbuncle difficulty is burst, and bursts for a long time and does not hold back.
Rhizoma Coptidis: bitter, cold; GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel; Pathogenic fire purging, dampness, removing toxic substances, parasite killing; Row pyretic toxicity when controlling, typhoid fever, intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, and diarrhea of heat type is suffered from abdominal pain, and lung knot is pressed, and tells, is defeated in battle, hematochezia, quench one's thirst, infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.
Cortex Phellodendri: bitter, cold; Return kidney, urinary bladder channel; Heat clearing away.Dampness, pathogenic fire purging, removing toxic substances.Control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, and hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.
Radix Scutellariae: bitter, cold; Return lung, gallbladder, spleen, large intestine, small intestine meridian; Removing the relative excess fire, except damp and hot, hemostasis, antiabortive.Control high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tell, be defeated in battle, collapse, leak, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.
Fructus Gardeniae: bitter, cold; GUIXIN, lung, tri-jiao channel; Fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.Root: eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis; For infectious hepatitis, traumatic injury, acute toothache.
Fructus Forsythiae: bitter, coolly returns; Lung, the heart, small intestine meridian; Heat clearing away, removing toxic substances, eliminating stagnation, detumescence; Control warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.
Flos Lonicerae: sweet, cold; Return lung, the heart, stomach warp; Heat-clearing and toxic substances removing, wind-heat dissipating; For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.
Herba Violae: bitter, cold; Enter the heart, Liver Channel; Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling; Control furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom.
Herba Artemisiae Annuae: bitter micro-pungent, cold; Return liver, gallbladder meridian; Clearing away summer-heat, except steaming, preventing the attack (or recurrence) of malaria; For pathogenic summer-heat heating, fever due to yin deficiency, night fever abating at dawn, hectic fever due to YIN-deficiency consumptive fever, malaria cold and heat, jaundice due to damp-heat.
Radix Isatidis: bitter, cold; GUIXIN, stomach warp.Heat clearing away, removing toxic substances, removing heat from blood; Control influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, pyretic toxicity sends out speckle, and coma tells nosebleed, pharyngeal swelling, mumps, acute catarrhal conjunctivitis, skin ulcer rash, and crimson tongue is purple dark, sore throat, scarlet fever, major part pestilence, carbuncle; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
Rhizoma Osmundae: bitter, cool; Return liver, stomach warp.Parasite killing, heat clearing away, removing toxic substances, cooling blood for hemostasis; Main anemopyretic cold, warm skin eruption, spit blood, hemoptysis, epistaxis, has blood in stool, metrorrhagia, dysentery, the intestinal parasitic diseases such as leukorrhagia and hook, ascarid, cestode.
Radix Glycyrrhizae: sweet, flat; GUIXIN, lung, spleen, stomach warp.With middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process use, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, infantile convulsion; Raw use, controls laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Above-mentioned major ingredient raw material itself have can directly deactivation or suppress virus effect and effect, by mass fraction ratio be: form major ingredient after Radix Astragali 50-100 part, Rhizoma Coptidis 50-100 part, Cortex Phellodendri 50-100 part, Radix Scutellariae 100-200 part, Fructus Gardeniae 50-100 part, Fructus Forsythiae 100-150 part, Flos Lonicerae 50-100 part, Herba Violae 100-150 part, Herba Artemisiae Annuae 100-150 part, Radix Isatidis 100-200 part, Rhizoma Osmundae 100-150 part, Radix Glycyrrhizae 50-100 part compatibility and can obtain good prevention effect.Adjuvant is food or the material of artificial letting animals feed, specifically refers to provide nutrient needed for letting animals feed, ensures healthy, promotes growth of animal, and the raised material of illeffects does not occur under reasonable employment, as feedstuff or water etc.Adjuvant and major ingredient directly can be mixed to form Chinese medicine composition, obtain the Chinese medicine composition of different curative effect through different implementation methods.Research experiment: giving this Chinese medicine composition of animal edible at interval of 6 days, edible 3 months continuously, result showed that the sickness rate of animal is below 6%; For the treatment occurring diseased n animal, this Chinese medicine composition edible is after 5 days continuously, and cure rate reaches more than 90%; Directly to animal edible after the major ingredient of Chinese medicine composition and adjuvant soak by water being filtered, every day 1 dose, serve on three, cure rate reaches more than 95%; According to investigations, " clear pestilence soup " (Gypsum Fibrosum, Natrii Sulfas, Folium Isatidis, Radix Isatidis, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, the Radix Rehmanniae, Radix Scrophulariae, Fructus Forsythiae, the Radix Glycyrrhizae etc.) decoction such as Li Yitian, in conjunction with antibiotic auxiliary treatment atypical swine fever such as dipyrones, accumulative treatment 244 altogether, cure 176, cure rate is about 70%.The prescription decoction such as the Radix Isatidis such as Zhang Zilong, Gypsum Fibrosum, the Radix Rehmanniae, Radix Platycodonis, Rhizoma Coptidis, Radix Scutellariae, Fructus Gardeniae, Radix Scrophulariae, Fructus Forsythiae, Flos Lonicerae, the Rhizoma Anemarrhenae, Flos Carthami, Radix Et Rhizoma Rhei, Natrii Sulfas, Radix Glycyrrhizae, arsenicum sablimatum card ear, in conjunction with treatment swine fevers such as erythromycin, chloromycetin, dipyrones, 245 examples, cure 192 examples, cure rate is 78%, as can be seen here, not the needing of this Chinese medicine composition adds other antibiotic, same effect that can have control to the disease such as livestock and poultry virus or antibacterial, and antiphlogistic antibacterial, heat-clearing and toxic substances removing, dampness removing and diarrhea-relieving better effects if, cure rate is higher.
Further, the para-infectious Chinese medicine composition of described control poultry bacterium, major ingredient raw material and its mass fraction ratio are: the Radix Astragali 50 parts, Rhizoma Coptidis 50 parts, Cortex Phellodendri 50 parts, Radix Scutellariae 100 parts, Fructus Gardeniae 50 parts, Fructus Forsythiae 100 parts, Flos Lonicerae 50 parts, Herba Violae 100 parts, Herba Artemisiae Annuae 100 parts, Radix Isatidis 100 parts, Rhizoma Osmundae 100 parts, 100 monthly ages, in certain plant, are 2 months and the pig of health is divided into experimental group and matched group by 50 parts, Radix Glycyrrhizae, and often organize 50, matched group and experimental group adopt identical feed for nursing, breeding technology and feeding environment are raised, raise three months, but experimental group added the major ingredient of above-mentioned mass fraction between feeding period in the feed supplementation of feeding at interval of 6 days, be that 2:1000 carries out spice by the mass fraction of major ingredient and feed supplementation, consist of Chinese medicine composition, the Chinese medicine composition mixed is boiled to animal pig feeding, observation through three months periods finds, statistics obtains the pig 7 of matched group generation disease, sickness rate 14%, and the pig of experimental group generation disease has 3, sickness rate only 6%, in addition, from the bodily form and the body weight that grow into 5 months stages, the average weight 124Kg of experimental group pig, the average weight 113Kg of matched group pig, the growth speed of pigs of experimental group comparatively matched group is fast, and the bodily form is also relatively large, and experimental group is heavier than matched group 9.7%, as can be seen here, Chinese medicine composition of the present invention not only plays good effect but also also has facilitation to the growth of pig in the prevention and control of disease.This is because the major ingredient material combination spot synergism of Chinese medicine composition of the present invention, the body's immunity of scalable animal, improve immunity and the anti-stress ability of animal body, being mainly manifested in one is by improving the phagocytic function of reticuloendothelial system, strengthen animal body cellular immunization and humoral immunization, as Flos Lonicerae, Radix Isatidis, Rhizoma Coptidis.Two is generations of inducing interferon, thus enhancing human body immunity reaction, as Herba Artemisiae Annuae; Three is the activation promoting macrophage, promotes lymphocytic generation, as Herba Violae.In addition, containing multivitamin and trace element in the Chinese medicine composition major ingredient selected of the present invention, the natural sex of Chinese herbal medicine itself and the little feature of toxic and side effects, with feed supplementation mixing to so have the growth of poultry and have good facilitation.
Further, major ingredient and feed supplementation are in the promising key of mass fraction ratio, if the mass fraction of major ingredient is high, the bitterness of major ingredient is obvious, animal is reluctant to eat, and the mass fraction of major ingredient is low, and the preventive effect for disease is unfavorable, by facts have proved: major ingredient and feed supplementation in mass fraction ratio be 2:1000 mixing to animal edible, the good and animal of the preventive effect for disease likes edible.
Further, the para-infectious Chinese medicine composition of control poultry bacterium, major ingredient raw material and its mass fraction are: the Radix Astragali 75 parts, Rhizoma Coptidis 75 parts, Cortex Phellodendri 75 parts, Radix Scutellariae 150 parts, Fructus Gardeniae 75 parts, Fructus Forsythiae 125 parts, Flos Lonicerae 75 parts, Herba Violae 125 parts, Herba Artemisiae Annuae 125 parts, Radix Isatidis 150 parts, Rhizoma Osmundae 125 parts, 75 parts, Radix Glycyrrhizae; Support in the breeding process of field certain pig, to occur between feeding period that 20 pigs of disease are divided into experimental group and matched group, often organize 10, matched group adopts the corresponding chemical medicine of injection disease to treat, experimental group adopts the major ingredient adding above-mentioned mass fraction in feed for nursing adjuvant to form Chinese medicine composition, and the mass fraction ratio of major ingredient and feed supplementation is 4:1000; Carry out nursing treatment, two schemes is respectively through after the treatment of 5 days, the cure rate of experimental group reaches 90%, and the cure rate 80% of matched group, find at therapeutic process, the Relapse rate outbreak of matched group pig, also adopt different chemical drugss to treat for different syndromes, Chinese medicine composition of the present invention is compared with chemicals as can be seen here, better at the therapeutic effect of disease, more stable to the control of the state of an illness in therapeutic process, and can carry out the treatment of various diseases simultaneously.
Further, for the treatment of disease, major ingredient and feed supplementation are in the promising key of mass fraction ratio, if the mass fraction of major ingredient is high, the bitterness of major ingredient is obvious, animal is reluctant to eat, the mass fraction of major ingredient is low, and the therapeutic effect for disease is unfavorable, by facts have proved: major ingredient and feed supplementation are that 4:1000 mixing is to animal edible in mass fraction ratio, stablize for Disease epizootic, therapeutic effect is obvious.
Further, the para-infectious Chinese medicine composition of control poultry bacterium, major ingredient raw material and its mass fraction ratio are: the Radix Astragali 100 parts, Rhizoma Coptidis 100 parts, Cortex Phellodendri 100 parts, Radix Scutellariae 200 parts, Fructus Gardeniae 100 parts, Fructus Forsythiae 150 parts, Flos Lonicerae 100 parts, Herba Violae 150 parts, Herba Artemisiae Annuae 150 parts, Radix Isatidis 200 parts, Rhizoma Osmundae 150 parts, 100 parts, Radix Glycyrrhizae.
In certain duckery's breeding process, there is bacterial diarrhea in duck group, to occur that 40 ducks of disease are divided into experimental group and matched group, often organize 20, matched group employing is fed corresponding chemical medicine and is treated, experimental group adopts and major ingredient of the present invention and water is formed Chinese medicine composition, gavage after direct decoction filtering to take to sick duck group and treat, two schemes is after the treatment of 3 days, the cure rate of experimental group reaches 95%, and the cure rate of matched group is 85%, the cure rate of experimental group is higher than matched group by 10%, in the control situation of the state of an illness, the treatment cure rate of 1 day of matched group is 60%, treat the cure rate 70% of 2 days, the cure rate for the treatment of 3 days is 85%, and the duck group of matched group after taking chemical drugs, there is inappetence on the whole in duck group, the state that spirit is not good enough, and the state of an illness again and again, and the cure rate that experimental group is treated 1 day is 50%, treating the cure rate after 2 days is 85%, the cure rate for the treatment of 3 days is 95%, the control of the state of an illness is stablized, as can be seen here, compared with chemical drugs Chinese medicine composition of the present invention in the treatment of disease with there is better curative effect, and to the control of the state of an illness and treatment rapider, by this Chinese medicine composition for animal duck group, good stably therapeutic effect can be obtained too, this Chinese medicine composition acts on differently on animal as can be seen here, control to stablize too to disease, respond well, the advantages such as short treating period.
Further, for the treatment occurring seriously disease small group, major ingredient and adjuvant water quality number ratio particularly crucial, if the mass fraction of major ingredient is high, effective ingredient is high, but the bitterness of major ingredient and abnormal smells from the patient obvious, animal is reluctant to take, the mass fraction of major ingredient is low, for the control of disease and therapeutic effect unfavorable, by facts have proved: major ingredient and adjuvant water are 1:10 in mass fraction ratio, after immersion, decoction, filtration cooling are taken to small group, small group is ready to take, and stablizes for Disease epizootic, and therapeutic effect is obvious.
The preparation method of the para-infectious Chinese medicine composition of control poultry bacterium, comprises major ingredient preparation, prepares major ingredient and comprise the following steps,
(1) remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae material medicine, the impurity in removing above-mentioned raw materials medicine;
(2) dry: adopt and under temperature is 35-60 DEG C of condition, material medicine is dried, the moisture 12-15% of medical material after drying;
(3) pulverize: the material medicine mixing pulverizer after drying is pulverized;
(4) sieve: sieved by the raw material after pulverizing, the order number of the screen cloth that sieves is 50-60 order;
(5) encapsulate: the composition of medicine after sifting out is carried out enclosed package.
The para-infectious Chinese medicine composition preparation method of control poultry bacterium, comprise major ingredient preparation, prepare major ingredient to comprise the following steps, remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae material medicine, remove the impurity such as the sandstone of above-mentioned raw materials medicine, dust or clod, prevent the existence of impurity from affecting the therapeutic effect of Chinese herbal medicine effective ingredients to disease; Dry: adopt oven drying method to dry material medicine, object one is that the material medicine after drying is beneficial to pulverizing; Two is that raw material after the drying directly carries out enclosed package after crushed, prevents from first pulverizing post-drying and the waste causing raw material is collected in medicinal raw material inconvenience after the pulverizing that causes; Three are, large quantity of moisture in removing medical material, avoids mouldy, variable color, the damage by worms decomposition and destruction that cause effective ingredient, ensures quality of medicinal material, is beneficial to storage.Pulverize: directly pulverize after the crude drug compatibility after drying with pulverizer, the raw material after pulverizing is not only beneficial to encapsulation and transport, also directly can mix with animal feed and be convenient to animal after boiling and swallow edible.Sieve: sieved by the raw material after pulverizing, the object of sieving is the uniformity ensureing Chinese medicine composition overall fineness after crushed further; Encapsulation: the composition of medicine after sieving is carried out enclosed package, is convenient to transport, sells after encapsulation, major ingredient also can be prevented moistureproof.Due to by the impact of natural conditions and the relation of itself character, all contain certain moisture, and water content because of its composition different with internal structure each variant.Chinese crude drug water content number, be not only an important indicator of ensuring the quality of products in storage process, be also impact in the principal element of storehouse Chinese crude drug mass change, mass change is played a leading role.The moisture of medical material is too high, easily becomes damp after storage and goes mouldy, and realize moisture too low, drying time is oversize, and even condition is harsh, proves that medical material moisture Control is at 12-15%, can ensure that medical material does not go mouldy and can save drying time by experiment.In baking step, the temperature of oven dry is at 40-60 DEG C; Dry temperature should control flexibly according to pharmaceutical properties, general medicine is advisable to be no more than 80 DEG C, be advisable to be no more than 50 DEG C containing the sufficient medical material of aromatic volatile, temperature too low being unfavorable for carries out dryly, the too high effective ingredient that may destroy raw material of temperature loses activity, selecting 40-60 DEG C according to the characteristic of traditional Chinese medicine composite of the present invention is optimum drying temperature range, has not only been beneficial to dryly but also has not destroyed former middle the effective elements of the medicine.The order number of screen cloth of sieving is 50-60 order, can not only ensure to pulverize the even of rear granularity, together with the experiment proved that obtaining major ingredient after sieving with order number 50-60 can be uniformly mixed better with adjuvant, boils rear animal and prefers to eat.The preparation method of the para-infectious Chinese medicine composition of this control poultry bacterium has the advantages such as operating process is simple, equipment cost is low, preparation expense is few.
The preparation method of the para-infectious Chinese medicine composition of control poultry bacterium, comprises major ingredient preparation, prepares major ingredient and comprise the following steps,
(1) remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae material medicine, chooses except the impurity in above-mentioned raw materials medicine;
(2) soak: the Radix Astragali taken, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, each part of Rhizoma Osmundae material medicine, add 2 times of distilled water immersion 2h;
(3) decoct: decoct twice after soaking, time first time decocts as 2h, and second time decocts and adds 2 times of distilled water, and decocting time is 2.5h;
(4) filter: all filter after having decocted cooling at every turn, filter to obtain filtering residue and filtrate.First time has decocted filters to obtain filtrate and for the first time filtering residue for the first time; Second time has decocted carries out second time filtration, obtains second time filtrate and second time filtering residue; To filtrate and second time filtrate merge for the first time, second time filtering residue is put in collecting bag;
(5) centrifugal: by centrifugal on centrifuge for the filtrate merged, after centrifugal, to get the supernatant;
(6) concentrated: concentrated by the supernatant after centrifugal, the concentrated supernatant obtains condensed cream;
(7) granulate: add granulation adjuvant at condensed cream, mixing is dry, granulates.
The para-infectious Chinese medicine composition preparation method of control poultry bacterium, it is characterized in that: comprise major ingredient preparation, prepare major ingredient to comprise the following steps, remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae material medicine, remove the impurity such as the sandstone of above-mentioned raw materials medicine, dust or clod, prevent the existence of impurity from affecting the therapeutic effect of Chinese herbal medicine effective ingredients to disease; Soak: take the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, each part of Rhizoma Osmundae material medicine, add 2 times of distilled water immersion 2h, the object of soaking makes distilled water immersion Chinese medicine composition, by the cell wall swelling of medical material, the effective ingredient in medicine can give full play of.Decoct: decoct twice after soaking, decocting time is 2h for the first time, and second time adds 2 times of distilled water and decocts, and decocting time is 2.5h; After first time decocts, middle the effective elements of the medicine major part decomposes out, so, when decocting secondary, just there is no need to soak again, but the time that the time that second time decocts decocted than first time is long, and be 2.5h, object is molten in solution for abundant effective ingredient can be separated.Filter: decocted at every turn and all to have filtered afterwards, filtered to obtain filtering residue and filtrate.First time has decocted filters to obtain filtrate and for the first time filtering residue for the first time; Second time has decocted carries out second time filtration, obtains second time filtrate and second time filtering residue; To filtrate and second time filtrate merge for the first time, second time filtering residue is put in collecting bag; Because first time filtrate active constituent content higher than second time filtrate active constituent content, so must be merged make all filtrate Chinese medicine ingredients concentration unanimously, such guarantee later stage concentrates the uniformity of rear effective ingredient.Centrifugal: by centrifugal on centrifuge for the filtrate merged, the supernatant is got after centrifugal, though filtrate solid concentration is after filtering relatively less, but still there is the thinner suspension of some granules, the existence of these tiny suspensions can affect the final performance of Effective Component of Chinese Medicine part, must be removed before concentration, the fine particle that in centrifugal process, in suspension, relative density is larger is deposited to bottom under the influence of centrifugal force and reaches the clarification of upper solution.Concentrated: concentrated by the supernatant after centrifugal, the concentrated supernatant obtains condensed cream.Concentrated is that the effective ingredient of supernatant is out made condensed cream by high technology equipment concentrated extract; Granulate: add granulation adjuvant at condensed cream, mixing is dry, makes granule.After Chinese herbal medicine is made granule, can not only enhance curative effect, be convenient to take, the granulation adjuvant added can also improve the mouthfeel of Chinese medicine composition further.
Further, the preparation method of the para-infectious Chinese medicine composition of control poultry bacterium, comprise major ingredient preparation, prepare the step of major ingredient, described step (4) and step (5) also comprise: dried by second time filtering residue, pulverize, sieve, encapsulation step; Described step (7) granulation adjuvant is dextrin, cane sugar powder, soluble starch, lactose, sodium cyclamate or its mixed accessories combined.Because major ingredient is after twice decoction filtering, though most of effective ingredient is extracted, but still have a small amount of effective ingredient to exist in second time filtering residue, if directly give up, its effective ingredient can be made to run off and to cause waste, if dried, pulverize, sieve, encapsulation process can also improve animal resistivity to animal edible, promote the growth of animal.Described step (7) granulation adjuvant is the mixing granulation adjuvant of dextrin, cane sugar powder, soluble starch, lactose and sodium cyclamate or combination in any.All can as a kind of granulation agent in dextrin, cane sugar powder, soluble starch, lactose and sodium cyclamate, also the mixing granulation adjuvant of granulation agent or the combination be applicable to can be selected according to the hobby of animal, the mouthfeel of the extremely bitter Chinese medicine ingredients of taste in granule can be improved, more easily accepted by animal.
Detailed description of the invention
The present invention prepare control the para-infectious Chinese medicine composition of poultry bacterium and mass fraction as shown in table 1:
Table 1
Above unit is g, for the embodiment one of table 1, the concrete preparation technology of the para-infectious Chinese medicine composition of above-mentioned control poultry bacterium is described:
(1) remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae material medicine, removes the impurity such as the sandstone of above-mentioned raw materials medicine, dust or clod;
(2) dry: the crude drug after remove impurity is put in integral type drying baker, under 40 DEG C of conditions, the (model of integral type drying baker: XF-LT-100Y is dried to material medicine in temperature; Manufacturer is Chengdu happiness blue sky Electrical Appliances Co., Ltd), at that time, after can stopping drying and namely drying, carry out above-mentioned each raw material being put in moistureproof cylinder (specification/model is 350mm, Shanghai Lei Gu Instrument Ltd. of manufacturer) cooling, for subsequent use;
(3) pulverize: take that moisture after drying is Radix Astragali 50g, the Rhizoma Coptidis 50g of 12%-15%, Cortex Phellodendri 50g, Radix Scutellariae 100g, Fructus Gardeniae 50g, Fructus Forsythiae 100g, Flos Lonicerae 50g, Herba Violae 100g, Herba Artemisiae Annuae 100g, Radix Isatidis 100g, Rhizoma Osmundae 100g, Radix Glycyrrhizae 50g quality compatibility form Chinese medicine composition, pulverizer is directly pulverized Chinese medicine composition; Pulverizer is the 30 type multipurpose crushers that Guangzhou Xu Lang plant equipment company limited produces; Technical parameter, voltage: 220 volts, power: 1500 watts (380V), 2200 watts of (220V) speeds of mainshaft: 5600 revs/min, smashing fineness: 5-80 order, volume of production: 20-200 kg/hour, size: 30 × 30 × 92 centimetres, weight: 50 kilograms;
(4) sieve: major ingredient after pulverizing is sieved at discharging opening 60 object screen clothes;
(5) encapsulate: by the major ingredient after sieving temperature be 25 ± 2 DEG C, under humidity≤50% condition, enclosed package is carried out by rotary racking machine, the manufacturer rotating racking machine is Anxi County area just outside a city gate brightness tea packaging machinery factory, technical parameter: power supply: 220V ± 10%; Power: 25W; Subpackage precision: 0-0.3; Separate-loading packaging: 10-20 beat/min;
(6) above-mentioned major ingredient and animal and fowl fodder are joined in 1000g poultry main feed adjuvant according to the ratio of 2:1000, be uniformly mixed by stirring rod, boiled, after cooling to room temperature, feed and eat to poultry.
Experiment: certain plant choose 100 2 months large and the pig of health is divided into two groups, be divided into experimental group and matched group, often organize 50, matched group and experimental group adopt identical feed for nursing, breeding technology and feeding environment are raised, but experimental group added Chinese medicine composition of the present invention at interval of 6 days and carries out nursing 1 day between feeding period in feed for nursing, continuous nursing three months, trimestral observation during passing through, statistics obtains the pig 7 of matched group generation disease, sickness rate 14%, and the pig of experimental group generation disease only has 3, sickness rate 6%, growing into 5 months this stage, matched group average weight 113Kg, experimental group average weight 124Kg, comparatively matched group is fast can to find out the growth speed of pigs of experimental group from data, build is also relatively large, experimental group is heavier than matched group 9.7%, this visible Chinese medicine composition of the present invention is had to serve good effect in the prevention of disease, and also have facilitation to the growth of pig.
For the embodiment two of table 1, the concrete preparation technology of the para-infectious Chinese medicine composition of above-mentioned control poultry bacterium is described:
(1) remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae major ingredient raw material, the solid impurities such as sandstone, dust or clod in removing above-mentioned raw materials;
(2) dry: the raw material after remove impurity is put in integral type drying baker, under 40 DEG C of conditions, the (model of integral type drying baker: XF-LT-100Y is dried to material medicine in temperature; Manufacturer is Chengdu happiness blue sky Electrical Appliances Co., Ltd), when moisture is 12%-15%, stop drying, the above-mentioned each raw material after oven dry is put in moistureproof cylinder (specification/model is 350mm, Shanghai Lei Gu Instrument Ltd. of manufacturer) for subsequent use;
(3) pulverize: the quality compatibility taking Radix Astragali 75g, Rhizoma Coptidis 75g, Cortex Phellodendri 75g, Radix Scutellariae 150g, Fructus Gardeniae 75g, Fructus Forsythiae 125g, Flos Lonicerae 75g, Herba Violae 125g, Herba Artemisiae Annuae 125g, Radix Isatidis 150g, Rhizoma Osmundae 150g, Radix Glycyrrhizae 75g after drying forms Chinese medicine major ingredient, and pulverizer is directly pulverized Chinese medicine major ingredient; Pulverizer is the 30 type multipurpose crusher (technical parameters that Guangzhou Xu Lang plant equipment company limited produces, voltage: 220 volts, power: 1500 watts (380V), the speed of mainshaft: 5600 revs/min, smashing fineness: 5-80 order, volume of production: 20-200 kg/hour, size: 30 × 30 × 92 centimetres, weight: 50 kilograms);
(4) sieve: the major ingredient after pulverizing is sieved at discharging opening 60 object screen clothes;
(5) encapsulate: the major ingredient after sieving is 25 ± 2 DEG C in temperature, under humidity≤50% condition, carries out enclosed package by rotary racking machine; The manufacturer rotating racking machine is Anxi County area just outside a city gate brightness tea packaging machinery factory, important technological parameters: power supply: 220V ± 10%; Power: 25W; Subpackage precision: 0-0.3; Separate-loading packaging: 10-20 beat/min;
Above-mentioned middle major ingredient and animal and fowl fodder are joined in animal and fowl fodder 1000g according to the ratio of 4:1000, is uniformly mixed by stirring rod, is boiled, after cooling to room temperature, feed poultry food.
Experiment: support in the breeding process of field certain pig, to occur between feeding period that 20 pigs of disease are divided into two groups, be divided into experimental group and matched group, often organize 10, matched group adopts the corresponding chemical medicine of injection disease to treat, experimental group adopts and add Chinese medicine composition of the present invention in nursing is raised, two schemes is after the treatment situation of 5 days, the cure rate of experimental group reaches 90%, and the cure rate 80% of matched group, in experimentation, the state of an illness of matched group to some extent repeatedly, the state of an illness is difficult to control, the Morbidity control of experimental group is stablized, there is not Relapse rate phenomenon, Chinese medicine composition of the present invention has better curative effect than chemical drugs in the treatment of disease as can be seen here, and disease is treated and controlled more to stablize.
For the embodiment three of table 1, illustrate that the para-infectious Chinese medicine composition of above-mentioned control poultry bacterium is for occurring the concrete preparation technology of serious symptom small group:
(1) remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae material medicine, removes the impurity such as the sandstone of above-mentioned major ingredient raw material, dust or clod;
(2) dry: the raw material after remove impurity is put in integral type drying baker, under 40 DEG C of conditions, the (model of integral type drying baker: XF-LT-100Y is dried to major ingredient raw material in temperature; Manufacturer is Chengdu happiness blue sky Electrical Appliances Co., Ltd), when moisture is 12%-15%, stop drying, carry out raw material each after above-mentioned oven dry being put in moistureproof cylinder (specification/model is 350mm, Shanghai Lei Gu Instrument Ltd. of manufacturer) cooling, for subsequent use;
(3) pulverize: the quality compatibility taking Radix Astragali 100g, Rhizoma Coptidis 100g, Cortex Phellodendri 100g, Radix Scutellariae 200g, Fructus Gardeniae 100g, Fructus Forsythiae 150g, Flos Lonicerae 100g, Herba Violae 150g, Herba Artemisiae Annuae 150g, Radix Isatidis 200g, Rhizoma Osmundae 150g, Radix Glycyrrhizae 100g after drying forms major ingredient, adopt pulverizer directly to pulverize major ingredient; Pulverizer is the 30 type multipurpose crushers that Guangzhou Xu Lang plant equipment company limited produces; Technical parameter, voltage: 220 volts, power: 1500 watts (380V), 220 watts (220V), the speed of mainshaft: 5600 revs/min, smashing fineness: 5-80 order, volume of production: 20-200 kg/hour, size: 30 × 30 × 92 centimetres, weight: 50 kilograms;
(4) sieve: the major ingredient after pulverizing is sieved at discharging opening 60 object screen clothes;
(5) encapsulate: by the composition of medicine after sieving temperature be 25 ± 2 DEG C, under humidity≤50% condition, enclosed package is carried out by rotary racking machine, the manufacturer rotating racking machine is Anxi County area just outside a city gate brightness tea packaging machinery factory, important technological parameters: power supply: 220V ± 10%; Power: 25W; Subpackage precision: 0-0.3; Separate-loading packaging: 10-20 beat/min;
(6) above-mentioned major ingredient and 1000g cold water are carried out compatibility according to the ratio that mass fraction is 1:10, soak 15 ± 5min; After immersion, 20-30min will be decocted with warm water, and then filter medicinal residues with gauze, get filtrate; Dropping to after 40 DEG C of temperature until filtrate gavages to the poultry occurring disease;
Experiment: in certain duckery's breeding process, there is seriously bacterial diarrhea in duck group, to occur that 40 ducks of serious symptom are divided into experimental group and matched group two groups, often organize 20, matched group employing is fed corresponding chemical medicine and is treated, experimental group adopts Chinese medicine composition of the present invention through decocting, filter, cool to room temperature gavages to sick duck group, two schemes is after the treatment of 3 days, the cure rate of experimental group reaches 95%, and the cure rate of matched group is 85%, the cure rate of experimental group is higher than matched group by 10%, in the control situation to the state of an illness, the treatment cure rate of 1 day of matched group is 60%, treat the cure rate 70% of 2 days, the cure rate for the treatment of 3 days is 85%, and the duck group of matched group after taking chemical drugs, there is inappetence on the whole in duck group, the state that spirit is not good enough, and the state of an illness again and again, and the cure rate that experimental group is treated 1 day is 60%, treating the cure rate after 2 days is 85%, and the cure rate for the treatment of 3 days is 95%, and the control of the state of an illness is stablized, when cure rate is 85%, the time adopting chemical drugs treatment is 3 days, and adopts traditional Chinese medicine composition for treating of the present invention only to need 2 days, and Chinese medicine composition of the present invention is shorter for the course for the treatment of in the treatment of disease compared with chemical drugs.As can be seen here, Chinese medicine composition of the present invention not only has better curative effect compared with chemical drugs, and to the control of the state of an illness and treatment more rapid, the course for the treatment of of treatment is shorter.This Chinese medicine composition also obtains good result on animal duck group, illustrate also Chinese medicine composition of the present invention act on differently animal upper time, disease is controlled and therapeutic effect too stable.
Embodiment four:
Compared with embodiment one, the preparation method of the para-infectious Chinese medicine composition of control poultry bacterium replaces with:
(1) remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae major ingredient raw material, removes the solid impurities such as the sandstone of above-mentioned raw materials medicine, dust or clod;
(2) soak: take Radix Astragali 50g, Rhizoma Coptidis 50g, Cortex Phellodendri 50g, Radix Scutellariae 100g, Fructus Gardeniae 50g, Fructus Forsythiae 100g, Flos Lonicerae 50g, Herba Violae 100g, Herba Artemisiae Annuae 100g, Radix Isatidis 100g, Rhizoma Osmundae 100g, Radix Glycyrrhizae 50g quality compatibility formed major ingredient put into extraction pot, the Chinese medicine extracting tank that extraction pot adopts Beijing Rui Na Xu Bang Science and Technology Ltd. to produce, (its major parameter is: extraction pot volume: 8m3; Water extraction temperature: 90 ~ 100 DEG C, extraction time: 5 ~ 6 hours/batches, vacuum was: 0.05 ~ 0.08Mpa; Use pressure is: 0.08 ~ 0.2Mpa), be that 1:2 ratio adds 1800g distilled water immersion 2h with mass ratio;
(3) decoct: decoct twice after soaking, decocting time is 2h for the first time, and the major parameter arranging extraction pot is: temperature, 100 DEG C, and extraction time is 2h, and vacuum is: 0.08Mpa; Use pressure is: 0.2Mpa; Heating extraction tank, extracts 2h; Second time adds the i.e. 1800g distilled water commensurability with first time and decocts, and decocting time is 2.5h, and the major parameter that extraction pot is arranged is identical with first time; All filter after each decoction;
(4) filter: use Hangzhou Feir Filter Technology Co., Ltd. to produce bag filter, after filtration, obtain filtering residue and filtrate.The major ingredient liquid decocted above-mentioned first time, filters and obtains first time filtrate, and proceed in drying, clean crock and hold; Filtering residue is poured in extraction pot and adds 1800g distilled water and carry out second time and decoct, carry out second time after decoction and filter, obtain the second filtrate, by first time filtrate and for the second time filtrate carry out being incorporated in same crock;
(5) centrifugal: by centrifugal on centrifuge for the filtrate merged, centrifuge adopts vertical vast capacity refrigerated centrifuger (model: DL7M-12L, technical parameter: maximum speed: 8000rpm; Max RCF: 12300 × g; Heap(ed) capacity: 14400ml; Rotary speed precision: ± 20r/min; Temperature-control range :-20 DEG C-+40; Accuracy of temperature control: ± 1 DEG C; Timing range: 1s-99h59min59s; Total noise of centrifuge :≤65dB; Overall dimensions: 960 × 860 × 1200mm; Weight: 500kg) temperature 25 DEG C, under rotating speed 3500r/min condition, after centrifugal 30min, get the supernatant;
(6) concentrated: the supernatant obtained to be moved in concentration tank and to concentrate, the vacuum decompressioning and concentrating tank that concentration tank adopts Beijing Rui Na Xu Bang Science and Technology Ltd. to produce, its major parameter is: steam pressure≤0.15Mpa, and vacuum≤700mmHg heating surface (area) (HS is 0.4m 2, under temperature is 80 ± 5 DEG C of conditions, the concentrated supernatant obtains condensed cream, and the relative density of condensed cream is 1.20;
(7) granulate: add by mass fraction 5% dextrin in Chinese medicine composition cream, mix homogeneously, spraying dry, the model adopting sky, Jiangyin City benefit environmental protection Yao Hua equipment company limited to produce is the Highspeedcentrifugingandsprayingdrier (inlet temperature: 140 ~ 350 DEG C of automatic controls of LPG series; Outlet temperature: 80-90 DEG C; Centrifugal atomizing nozzle rotation formula: pneumatic transmission; Rotating speed (r.p.m): 25000; Spray disk diameter (mm): 50; Long × wide × high (m): 1.8 × 0.9 × 2.2; Dry powder response rate %: be >=95%) 1.5 ~ 1.6Pa at atomisation pressure, flow velocity 3 ~ 4mlmin, temperature of charge 60 ~ 70 DEG C, in whole process of the test, spraying dry in order, obtained granule.
(8) encapsulate: by obtained granule temperature be 25 ± 2 DEG C, under humidity≤50% condition, enclosed package is carried out by rotary racking machine, the manufacturer rotating racking machine is Anxi County area just outside a city gate brightness tea packaging machinery factory, important technological parameters: power supply: 220V ± 10%; Power: 25W; Subpackage precision: 0-0.3; Separate-loading packaging: 10-20 beat/min.
(9) get above-mentioned major ingredient and 1000g warm water carries out compatibility according to the ratio that mass fraction is 1:10, directly gavage to the poultry occurring disease after major ingredient dissolves.
Experiment: in certain chicken farm breeding process, there is viral infectious diseases in chicken group, to occur that 20 chickens of disease are divided into experimental group and matched group, often organize 10, matched group employing is fed corresponding chemical medicine and is treated, experimental group gavages to the chicken group suffering from disease after adopting and being mixed with adjuvant water by Chinese medicine composition major ingredient granule of the present invention, once a day, two schemes is after the treatment situation of 3 days, two schemes is after the treatment of 3 days, the cure rate of experimental group reaches 98%, and the cure rate of matched group is 85%, adopt the cure rate of Chinese medicine composition concentrated granular of the present invention higher than matched group by 13%, in the control situation to the state of an illness, the treatment cure rate of 1 day of matched group is 60%, treat the cure rate 70% of 2 days, the cure rate for the treatment of 3 days is 85%, and the chicken group of matched group employing chemical drugs treatment after, there is inappetence on the whole in duck group, the state that spirit is not good enough, the state of an illness again and again, and the cure rate that experimental group is treated 1 day is 75%, treating the cure rate after 2 days is 90%, the cure rate for the treatment of 3 days is 95%, in addition, in experimentation, the chicken group of matched group shows struggle very much, resist when adopting chemicals treatment, and the chicken of experimental group adopts Chinese medicine composition of the present invention to gavage not revolt and show very docile.As can be seen here, Chinese medicine composition of the present invention has good curative effect equally in the treatment of virus infection.Therefore, major ingredient of the present invention through concentrated make granule and adjuvant water dissolution after in the treatment of disease, not only there is better curative effect, and to the control of the state of an illness and treatment more rapidly, the required course for the treatment of is shorter.
For a person skilled in the art, under the prerequisite not departing from structure of the present invention, can also make some distortion and improvement, these also should be considered as protection scope of the present invention, and these all can not affect effect of the invention process and practical applicability.

Claims (10)

1. prevent and treat the para-infectious Chinese medicine composition of poultry bacterium, it is characterized in that: be made up of major ingredient and adjuvant; Major ingredient raw material and its mass fraction ratio are: Radix Astragali 50-100 part, Rhizoma Coptidis 50-100 part, Cortex Phellodendri 50-100 part, Radix Scutellariae 100-200 part, Fructus Gardeniae 50-100 part, Fructus Forsythiae 100-150 part, Flos Lonicerae 50-100 part, Herba Violae 100-150 part, Herba Artemisiae Annuae 100-150 part, Radix Isatidis 100-200 part, Rhizoma Osmundae 100-150 part, Radix Glycyrrhizae 50-100 part.
2. prevent and treat the para-infectious Chinese medicine composition of poultry bacterium as claimed in claim 1, it is characterized in that: major ingredient raw material and its mass fraction ratio are: the Radix Astragali 50 parts, Rhizoma Coptidis 50 parts, Cortex Phellodendri 50 parts, Radix Scutellariae 100 parts, Fructus Gardeniae 50 parts, Fructus Forsythiae 100 parts, Flos Lonicerae 50 parts, Herba Violae 100 parts, Herba Artemisiae Annuae 100 parts, Radix Isatidis 100 parts, Rhizoma Osmundae 100 parts, 50 parts, Radix Glycyrrhizae.
3. prevent and treat the para-infectious Chinese medicine composition of poultry bacterium as claimed in claim 2, it is characterized in that: described adjuvant is feedstuff, major ingredient and quality of the fodder number ratio are 2:1000.
4. prevent and treat the para-infectious Chinese medicine composition of poultry bacterium as claimed in claim 1, it is characterized in that: major ingredient raw material and its mass fraction are: the Radix Astragali 75 parts, Rhizoma Coptidis 75 parts, Cortex Phellodendri 75 parts, Radix Scutellariae 150 parts, Fructus Gardeniae 75 parts, Fructus Forsythiae 125 parts, Flos Lonicerae 75 parts, Herba Violae 125 parts, Herba Artemisiae Annuae 125 parts, Radix Isatidis 150 parts, Rhizoma Osmundae 125 parts, 75 parts, Radix Glycyrrhizae.
5. prevent and treat the para-infectious Chinese medicine composition of poultry bacterium as claimed in claim 4, it is characterized in that: described adjuvant is feedstuff, major ingredient and quality of the fodder number ratio are 4:1000.
6. prevent and treat the para-infectious Chinese medicine composition of poultry bacterium as claimed in claim 1, it is characterized in that: major ingredient raw material and its mass fraction ratio are: the Radix Astragali 100 parts, Rhizoma Coptidis 100 parts, Cortex Phellodendri 100 parts, Radix Scutellariae 200 parts, Fructus Gardeniae 100 parts, Fructus Forsythiae 150 parts, Flos Lonicerae 100 parts, Herba Violae 150 parts, Herba Artemisiae Annuae 150 parts, Radix Isatidis 200 parts, Rhizoma Osmundae 150 parts, 100 parts, Radix Glycyrrhizae.
7. prevent and treat the para-infectious Chinese medicine composition of poultry bacterium as claimed in claim 6, it is characterized in that: described adjuvant is water, the mass fraction ratio of major ingredient and water is 1:10.
8. prevent and treat the preparation method of the para-infectious Chinese medicine composition of poultry bacterium as claimed in claim 1, it is characterized in that: comprise major ingredient preparation, prepare major ingredient and comprise the following steps,
(1) remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae major ingredient raw material, the impurity in removing above-mentioned raw materials medicine;
(2) dry: adopt and dry material medicine at 35-60 DEG C of temperature, after drying, the moisture of medical material is 12-15%;
(3) pulverize: the material medicine mixing pulverizer after drying is pulverized;
(4) sieve: sieved by the major ingredient after pulverizing, the order number of the screen cloth that sieves is 50-60 order;
(5) encapsulate: the major ingredient after sieving is carried out enclosed package.
9. prevent and treat the preparation method of the para-infectious Chinese medicine composition of poultry bacterium as claimed in claim 1, it is characterized in that: comprise major ingredient preparation, prepare major ingredient and comprise the following steps,
(1) remove impurity: select the Radix Astragali, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, Rhizoma Osmundae major ingredient raw material, choose except the impurity in above-mentioned raw materials medicine;
(2) soak: the Radix Astragali taken, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Glycyrrhizae, Fructus Gardeniae, Herba Violae, Herba Artemisiae Annuae, each part of Rhizoma Osmundae major ingredient raw material, add 2 times of distilled water immersion 2h;
(3) decoct: decoct twice after soaking, decocting time is 2h for the first time, and second time decocts and adds 2 times of distilled water, and decocting time is 2.5h;
(4) filter: all filter after having decocted cooling at every turn, filter to obtain filtering residue and filtrate; First time has decocted filters to obtain filtrate and for the first time filtering residue for the first time; Second time has decocted carries out second time filtration, obtains second time filtrate and second time filtering residue; To filtrate and second time filtrate merge for the first time, second time filtering residue is put in collecting bag;
(5) centrifugal: by centrifugal on centrifuge for the filtrate merged, after centrifugal, to get the supernatant;
(6) concentrated: concentrated by the supernatant after centrifugal, the concentrated supernatant obtains condensed cream;
(7) granulate: add granulation adjuvant at condensed cream, mixing is dry, granulates.
10. prevent and treat the preparation method of poultry bacterium para-infectious Chinese medicine composition as claimed in claim 9, it is characterized in that: also comprise between described step (4) and step (5): second time filtering residue dried, pulverizes, sieve, encapsulation step; Described step (7) granulation adjuvant is dextrin, cane sugar powder, soluble starch, lactose, sodium cyclamate or its mixed accessories combined.
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CN113318175A (en) * 2021-04-26 2021-08-31 黄德荣 Chinese herbal medicine for sterilizing and disinfecting by utilizing smell and treating skin diseases and preparation method thereof

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