CN105168588A - Traditional Chinese medicine composition for fish for eating as well as preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for fish for eating as well as preparation method and application of traditional Chinese medicine composition Download PDFInfo
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- CN105168588A CN105168588A CN201510691285.2A CN201510691285A CN105168588A CN 105168588 A CN105168588 A CN 105168588A CN 201510691285 A CN201510691285 A CN 201510691285A CN 105168588 A CN105168588 A CN 105168588A
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Abstract
The invention provides a traditional Chinese medicine composition for fish for eating as well as a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is mainly prepared from the following components in parts by weight: 10-20 parts of cortex phellodendri, 10-30 parts of rheum officinale, 10-20 parts of scutellaria baicalensis, 10-20 parts of silybum marianum, 5-10 parts of mulberry leaves, 5-10 parts of semen cuscutae, 5-10 parts of radix gentianae, 2-5 parts of wolfberries, 3-10 parts of codonopsis pilosula, 5-10 parts of radix bupleuri, 3-10 parts of dandelion, 5-20 parts of astragalus membranaceus, 2-8 parts of liquorice, 2-10 parts of semen cassia, 5-15 parts of fennel and 5-20 parts of cinnamon. The method comprises the following steps: distilling, extracting, filtering and concentrating the cortex phellodendri, the rheum officinale, the scutellaria baicalensis, the semen cuscutae, the mulberry leaves, the codonopsis pilosula, the liquorice and the radix bupleuri to obtain thick paste; simultaneously crushing the residual components into micro powder; and mixing and stirring the thick paste with the micro powder evenly, and drying the mixture to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention is used for preventing and treating fatty liver diseases of the fish and improving the food calling function of the feed.
Description
Technical field
The present invention relates to the field of Chinese medicines, in particular to a kind of Chinese medicine composition edible for Fish and preparation method thereof, application.
Background technology
Fatty Liver Disease is the common disease of cultured fishes, and ill fish there is no obvious body surface symptom, rarely seen inappetence, poor growth, the phenomenon that the low grade of the price of deed is not easily discovered.Pathological anatomy is shown in that liver surface has fatty tissue to accumulate, or intestinal tube surface fat covers obviously, hepatic cell fattydegeneration is obvious, main liver function enzyme index is abnormal, and hepatic insufficiency, causes cultivation of fish grow slow, even dead, mortality rate can reach 30-50%, and therefore this type disease needs to cause raiser's attention especially, in order to avoid be subjected to inevitable economic loss.
At present, the main method of preventing and treating fatty,fiss hepatopathy in feedstuff, adds some materials being conducive to lipid metabolism, as vitamin B, vitamin E, choline chloride etc.Antibiotics is mainly adopted to treat this kind of disease clinically.But, scientific research and production practices show, long-term, high-dose uses antibiotic to there is serious negative effect, not only cause fish enteric flora disturbance, bacterial drug resistance to strengthen, cause anaphylaxis or toxic and side effects, also have a strong impact on animal product quality and edible safety, directly affect human health.Research day by day along with people finds that Chinese medicine preparation is owing to having the features such as toxic and side effects is little, pathogen not easily develops immunity to drugs, environmentally friendly, and more and more come into one's own, the application in aquaculture production is increasingly extensive.But Chinese medicine preparation itself exists the problem of palatability difference, and cultured fishes are eating not, the effect for the treatment of fatty,fiss hepatopathy therefore conscientiously can not be reached.
In view of this, special proposition the present invention.
Summary of the invention
The first object of the present invention is to provide a kind of Chinese medicine composition edible for Fish, described Chinese medicine composition has property of medicine gentleness, naturally to have no side effect, not only can repair the liver function of fish, promote the lipid metabolism of cultured fishes liver cell effectively to improve the advantages such as luring function.
The second object of the present invention is the preparation method providing a kind of described Chinese medicine composition supplying Fish to eat, and this preparation method is simple, easy to operate, and active ingredient, the treatment conditions with each component of the complete reservation of energy are gentleer, low cost and other advantages.
The third object of the present invention is to provide a kind of described Chinese medicine composition supplying Fish to eat to have very strong effect in control fish fats hepatopathy and raising feedstuff luring function.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
Embodiments provide a kind of Chinese medicine composition edible for Fish, it forms primarily of following component: in mass fraction, Cortex Phellodendri 10-20 part, Radix Et Rhizoma Rhei 10-30 part, Radix Scutellariae 10-20 part, Herba Silybi mariani 10-20 part, Folium Mori 5-10 part, Semen Cuscutae 5-10 part, Radix Gentianae 5-10 part, Fructus Lycii 2-5 part, Radix Codonopsis 3-10 part, Radix Bupleuri 5-10 part, Herba Taraxaci 3-10 part, Radix Astragali 5-20 part, Radix Glycyrrhizae 2-8 part, Semen Cassiae 2-10 part, Fructus Foeniculi 5-15 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5-20 part
The Chinese medicine composition edible for Fish that the embodiment of the present invention provides, can be good at treatment fatty,fiss hepatopathy, and Chinese medicine composition of the present invention effectively can also improve the palatability of Fish, mix and can not be repelled by Fish because mouthfeel is bad in feedstuff, the contrary appetite that can also promote Fish, thus in process on the feed, reach the object for the treatment of fish disease easily, be kill two birds with one stone, the proportioning of each component in addition in compositions all has certain control, drug effect due to Chinese medicine needs each component mutual 5 to be equipped with to achieve the goal, if therefore arbitrarily component is measured its drug effect excessive and is reached peak, add also unhelpful again, and very few its drug effect that do not make on the contrary added gives full play of, therefore suitable proportioning seems particularly important.
In the present invention, Cortex Phellodendri, from the dry bark of rutaceae wampee or Cortex Phellodendri, has heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat, for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire, its general addition is 10-20 part, and more excellent is 12-18 part, and optimum is 17 parts, can also select 11 parts, 13 parts, 15 parts or 16 parts etc.
Radix Et Rhizoma Rhei is from the dry root welding technology of sorrel, Rheum officinale, Rheum tanguticum, have and attack the effects such as stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances, general addition controls 10-30 part, more excellent is 12-24 part, optimum is 20 parts, can also select 11 parts, 13 parts, 15 parts or 21 parts etc.
Radix Scutellariae is the dry root of labiate Radix Scutellariae, has heat clearing and damp drying, and removing heat from blood is antiabortive, detoxicating functions.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle, general addition is 10-20 part, more excellent is 11-14 part, optimum is 13 parts, can also select 11 parts, 15 parts or 19 parts etc.
Herba Silybi mariani is the dry mature fruit of feverfew Herba Silybi mariani.Cold in nature, bitter in the mouth itself, has heat-clearing and toxic substances removing, protects the liver, function of gallbladder promoting, and protect brain, effect of anti-X-ray, general addition is 10-20 part, and more excellent be 15-18 part, optimum be 16 parts, 11 parts, 13 parts or 19 parts etc. can also be selected.
Folium Mori are the dried leaves of moraceae plants Mulberry.Have dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, effect of liver heat removing and eyesight improving, for anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted, and general addition is 5-10 part, and more excellent is 7-9 part, and optimum is 8 parts, can also select 6 parts.
Semen Cuscutae is the dry mature seed of convolvulaceous plant Cuscuta australis or Semen Cuscutae.Warm in nature, sweet in the mouth, suffers from a deficiency of the kidney rush down for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen, and general addition is 5-10 part, and more excellent is 7-9 part, and optimum is 8 parts, can also select 6 parts.
Radix Gentianae is the dry root welding technology of gentianaceae plant Gentiana manshurica, Radix Gentianae, G. triflora or Yunnan Radix Gentianae.Have effect of heat clearing away, eliminating pathogen in the liver, arresting convulsion, general addition is 5-10 part, and more excellent is 8-9 part, and optimum is 8 parts, can also select 6 parts or 7 parts.
Fructus Lycii is the dry mature fruit of plant of Solanaceae lycium barbarum.Sweet in the mouth own, have the effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight, modern medicine study proves, suitably take Fructus Lycii and can play effects such as strengthening immunity, general addition is 2-5 part, and more excellent is 3-4 part, and optimum is 3 parts.
Radix Codonopsis this product Campanulaceae Radix Codonopsis, element spend ten behaviour's roots of Radix Codonopsis or radix codonpsis tangshen.Property is put down, and sweet in the mouth, micro-acid, have invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting, for deficiency of the spleen and lung, to breathe hard cardiopalmus, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst, general addition is 3-10 part, and more excellent is 4-8 part, and optimum is 6 parts, can also select 5 parts or 7 parts.
Radix Bupleuri is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Bitter in the mouth, cold nature, there is the effects such as expelling pathogenic factors from the exterior expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, be widely used in the diseases such as cold, fever, alternate attack of chill and fever, malaria, distending pain in the chest and hypochondrium, proctoptosis, uterine prolapse, menoxenia, general addition is 5-10 part, more excellent is 6-9 part, and optimum is 7 parts, can also select 8 parts.
Herba Taraxaci is feverfew Herba Taraxaci, alkali ground Herba Taraxaci or belong to the dry herb of several plants together, nature and flavor are sweet, bitter, cold, there is the several functions such as heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, antiinflammatory, removing heat from blood, diuresis, function of gallbladder promoting, hypocatharsis, stomach invigorating, anti-cancer, general addition is 3-10 part, more excellent is 4-8 part, optimum is 6 parts, can also select 5 parts or 9 parts etc.
The Radix Astragali is the dry root of leguminous plant Radix Astagali or Radix Astragali.Property sweet temperature, return lung meridian, have tonifying Qi and lifting yang, function that benefit defends consolidating superficial resistance, the conventional function with disease-prevention health, general addition is 5-20 part, and more excellent be 7-10 part, optimum be 9 parts, 6 parts, 8 parts, 11 parts, 12 parts or 13 parts etc. can also be selected.
Radix Glycyrrhizae is the dry root welding technology of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Property flat, sweet in the mouth, there is removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic so that the pharmacological action such as anticancer, general addition is 2-8 part, and more excellent is 3-5 part, optimum be 4 parts, 6 parts or 7 parts etc. can also be selected.
Semen Cassiae is the dry mature seed of leguminous plant Semen Cassiae or little Semen Cassiae.Bitter in the mouth, treatment constipation and hyperlipidemia, hypertension, liver heat removing and eyesight improving, diuretic relieving constipation, has laxative action, effect of reducing blood pressure and blood fat, and general addition is 2-10 part, and more excellent is 3-8 part, and optimum is 7 parts, can also select 4 parts or 5 parts etc.
Fructus Foeniculi is the dry mature fruit of samphire.Warm in nature, acrid in the mouth, cures mainly cold in middle-JIAO, loss of appetite, nausea and vomiting, abdominal part cold type of pain; Hernia pain, painful and swollen testis; Stagnation of QI in spleen and stomach, distension and fullness in the abdomen is had a pain.General addition is 5-15 part, and more excellent is 8-12 part, and optimum is 10 parts, can also select 6 parts or 7 parts etc.
Cortex cinnamomi japonici (Ramulus Cinnamomi) is the common name of the barks such as Lauraceae, cinnamon Cinnamomum japonica, cloudy perfume, cinnamomum chingii Metcalf, Cortex Cinnamomi or osmanthus, river.Acrid in the mouth, sweet, hot in nature, cure mainly decline of the fire from the gate of life, the disease such as cold extremities faint pulse, YANG-depletion collapse, stomachache are had loose bowels, colic of cold type, chills and pain of the waist and kness, carbuncle of yin nature multiple abscess, the floating inducing vomiting heat in the upper and cold in the lower of empty sun, general addition is 5-20 part, more excellent is 7-15 part, optimum is 10 parts, can also select 6 parts, 8 parts, 11 parts, 12 parts or 13 parts etc.
As can be seen from each component of above Chinese medicine composition of the present invention, ingredients of the present invention is partially bitter, drug effect is improved in order to better regulate mouthfeel, the present invention is also creationary with the addition of this component of Semen Sesami, consumption is 5-10 part, Semen Sesami can be used for that treatment physical weakness, dizziness and tinnitus, hypertension, hyperlipidemia, cough, physical weakness, early whitening of hair, anemia are sallow, deficiency of body fluid, constipation due to dry stool, breast less, the disease such as hematuria, optimum can add 7 parts.
Merit attention and be, each component in Chinese medicine composition of the present invention is all that inventor carries out choosing carefully gained for drug effect in numerous medical material, each component is specific for product of the present invention, consumption also needs to prepare burden in strict accordance with method of the present invention, because after the Chinese medicine composition only combined with specific components of the present invention eats for Fish, just have and promote Fish appetite, improve the dual function of luring function and control fatty,fiss hepatopathy, lack any one component and all do not reach such effect, Chinese medicine composition of the present invention not only can repair the liver function of fish to a certain extent, promote the lipid metabolism of cultured fishes liver cell, also to the Fatty Liver Disease of cultured fishes, there is significant preventive and therapeutic effect, Be very effective, product of the present invention is not containing any chemical substance in addition, the ammonia nitrogen discharge etc. to environment can be reduced after using, reduce environmental pollution, to the mankind and environmentally friendly, environmental protection.
The present invention, except providing a kind of Chinese medicine composition edible for Fish, additionally provides the preparation method of this Chinese medicine composition, comprises the steps:
Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Semen Cuscutae, Folium Mori, Radix Codonopsis, Radix Glycyrrhizae and Radix Bupleuri distillation extraction, filtering and concentrating are obtained thick paste, and residue component be ground into micropowder simultaneously, after described thick paste and described micropowder are uniformly mixed, is drying to obtain.
Not only preparation method is simple for the preparation method of the embodiment of the present invention, and it is easy to operate, flexible, can be good at the effective ingredient retaining each component, also have in preparation process, after classification process being carried out to it according to the characteristic of every taste medical material, remerge stirring, drying obtains final products, this preparation method very scientific and effective, in order to improve drying efficiency, drying mode preferably adopts spraying dry.The stir speed (S.S.) of mix and blend preferably controls at 50-100rad/min, stir speed (S.S.) can not too fast can not be excessively slow, the too fast drug effect destroying medical material, the stirred effect not having mix homogeneously slowly.
Preferably, the total time of distillation extraction controls at 70-90min, repeatedly extracts 2-3 time, effective ingredient can be ensured so fully to extract.
Preferably, described thick paste comprises following post processing: pulverize after being cooled to room temperature, crosses the sieve of more than 60 orders, is namely ground into the powdery that order granularity is at least more than 60 orders.Fully thick paste is ground, improve uniformity when follow-up its mixes with micropowder, thus improve the drug effect of product.Same, also need to control certain granularity to improve homogeneity micropowder, the granularity control of described micropowder is below 75 μm, and moisture Control is at below 8wt%, if too high its of moisture not easily mixes, has granular sensation and also has impact to drug effect.
Finally, after described thick paste and described micropowder are uniformly mixed, preferably add the 0.5-2 pharmaceutic adjuvant doubly of the gross mass of described thick paste and described micropowder, pharmaceutic adjuvant refers in addition to the active ingredient (s, the excipient used when producing medicine and prescription being dispensed and additives, such as adhesive, disintegrating agent, filler, lubricant etc., its except figuration, serve as carrier, improve except stability, also there is the critical functions such as solubilising, hydrotropy, slow controlled release, therefore preferably suitable interpolation is a certain amount of enters, but will control consumption well.
The Chinese medicine composition of the embodiment of the present invention has good application in control fish fats hepatopathy and raising feedstuff luring function.
Compared with prior art, beneficial effect of the present invention is:
(1) the invention provides a kind of Chinese medicine composition edible for Fish, the property of medicine is gentle, naturally has no side effect, and can not only repair the liver function of fish, promote the lipid metabolism of cultured fishes liver cell effectively to improve luring function;
(2) the present invention is easy to use for the Chinese medicine composition that Fish are edible, directly mixes inside fish meal, effectively improves palatability and the attractant of feedstuff, promote the feed intake of fish, improve daily gain, completely not containing any antibiotic, Drug resistance is not remarkable, performance variation, cost is low, and should be widely promoted application, and not containing any chemical substance, the ammonia nitrogen discharge etc. to environment can be reduced after using, reduce environmental pollution;
(3) not only preparation method is simple for the preparation method of the embodiment of the present invention, and it is easy to operate, flexible, can be good at the effective ingredient retaining each component, also have in preparation process, after classification process being carried out to it according to the characteristic of every taste medical material, remerge stirring, drying obtains final products, this preparation method very scientific and effective.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, be and can buy by commercially available the conventional products obtained.
Embodiment 1
The preparation method of the Chinese medicine composition supplying Fish to eat is as follows:
1) each medical material is taken by following quality: Cortex Phellodendri 10g, Radix Et Rhizoma Rhei 10g, Radix Scutellariae 10g, Herba Silybi mariani 10g, Folium Mori 5g, Semen Cuscutae 5g, Radix Gentianae 5g, Fructus Lycii 2g, Radix Codonopsis 3g, Radix Bupleuri 5g, Herba Taraxaci 3g, Radix Astragali 5g, Radix Glycyrrhizae 2g, Semen Cassiae 2g, Fructus Foeniculi 5g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5g;
2) by Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Semen Cuscutae, Folium Mori, Radix Codonopsis, Radix Glycyrrhizae and the rear 100 DEG C of distilled water extraction of Radix Bupleuri cleaning, filtered while hot, by extracting liquid filtering simmer down to thick paste, for subsequent use;
3) Herba Silybi mariani, Radix Gentianae, Fructus Lycii, Herba Taraxaci, the Radix Astragali, Semen Cassiae, Fructus Foeniculi, Cortex cinnamomi japonici (Ramulus Cinnamomi) are made micropowder after super micron mill is pulverized, and after being mixed homogeneously with thick paste by micropowder and stirring, make granule through vacuum spray drying process.
Embodiment 2
The preparation method of the Chinese medicine composition supplying Fish to eat is as follows:
1) each medical material is taken by following quality: Cortex Phellodendri 20g, Radix Et Rhizoma Rhei 30g, Radix Scutellariae 20g, Herba Silybi mariani 20g, Folium Mori 10g, Semen Cuscutae 10g, Radix Gentianae 10g, Fructus Lycii 5g, Radix Codonopsis 10g, Radix Bupleuri 10g, Herba Taraxaci 10g, Radix Astragali 20g, Radix Glycyrrhizae 8g, Semen Cassiae 10g, Fructus Foeniculi 15g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 20g;
2) by Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Semen Cuscutae, Folium Mori, Radix Codonopsis, Radix Glycyrrhizae and the rear 100 DEG C of distilled water extraction 70min altogether of Radix Bupleuri cleaning, repeatedly extract each 35min of secondary, filtered while hot, by extracting liquid filtering simmer down to thick paste, pulverize after being cooled to room temperature, cross 60 mesh sieves;
3) Herba Silybi mariani, Radix Gentianae, Fructus Lycii, Herba Taraxaci, the Radix Astragali, Semen Cassiae, Fructus Foeniculi, Cortex cinnamomi japonici (Ramulus Cinnamomi) are made after super micron mill is pulverized the micropowder of granularity≤75 μm, moisture≤wt8%, and after micropowder is mixed homogeneously with thick paste stirring, add the 0.5-2 pharmaceutic adjuvant doubly of the gross mass of thick paste and described micropowder, make granule finally by vacuum spray drying process.
Embodiment 3
The preparation method of the Chinese medicine composition supplying Fish to eat is as follows:
1) each medical material is taken by following quality: Cortex Phellodendri 12g, Radix Et Rhizoma Rhei 12g, Radix Scutellariae 11g, Herba Silybi mariani 15g, Folium Mori 7g, Semen Cuscutae 7g, Radix Gentianae 8g, Fructus Lycii 3g, Radix Codonopsis 4g, Radix Bupleuri 6g, Herba Taraxaci 4g, Radix Astragali 7g, Radix Glycyrrhizae 3g, Semen Cassiae 3g, Fructus Foeniculi 8g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 7g;
2) by Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Semen Cuscutae, Folium Mori, Radix Codonopsis, Radix Glycyrrhizae and the rear 100 DEG C of distilled water extraction 90min altogether of Radix Bupleuri cleaning, repeatedly extract three each 30min, filtered while hot, by extracting liquid filtering simmer down to thick paste, pulverize after being cooled to room temperature, cross 70 mesh sieves;
3) Herba Silybi mariani, Radix Gentianae, Fructus Lycii, Herba Taraxaci, the Radix Astragali, Semen Cassiae, Fructus Foeniculi, Cortex cinnamomi japonici (Ramulus Cinnamomi) are made after super micron mill is pulverized the micropowder of granularity 70 μm, moisture≤wt7%, and after micropowder is mixed homogeneously with thick paste stirring, add the 0.5-2 pharmaceutic adjuvant doubly of the gross mass of thick paste and described micropowder, make granule finally by vacuum spray drying process.
Embodiment 4
The preparation method of the Chinese medicine composition supplying Fish to eat is as follows:
1) each medical material is taken by following quality: Cortex Phellodendri 18g, Radix Et Rhizoma Rhei 24g, Radix Scutellariae 14g, Herba Silybi mariani 18g, Folium Mori 9g, Semen Cuscutae 9g, Radix Gentianae 9g, Fructus Lycii 4g, Radix Codonopsis 8g, Radix Bupleuri 9g, Herba Taraxaci 8g, Radix Astragali 10g, Radix Glycyrrhizae 5g, Semen Cassiae 8g, Fructus Foeniculi 12g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 15g;
2) by Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Semen Cuscutae, Folium Mori, Radix Codonopsis, Radix Glycyrrhizae and the rear 100 DEG C of distilled water extraction 80min altogether of Radix Bupleuri cleaning, repeatedly extract twice each 40min, filtered while hot, by extracting liquid filtering simmer down to thick paste, pulverize after being cooled to room temperature, cross 75 mesh sieves;
3) Herba Silybi mariani, Radix Gentianae, Fructus Lycii, Herba Taraxaci, the Radix Astragali, Semen Cassiae, Fructus Foeniculi, Cortex cinnamomi japonici (Ramulus Cinnamomi) are made after super micron mill is pulverized the micropowder of granularity≤75 μm, moisture≤wt8%, and after micropowder is mixed homogeneously with thick paste stirring, add the 0.5-2 pharmaceutic adjuvant doubly of the gross mass of thick paste and described micropowder, make granule finally by vacuum spray drying process.
Embodiment 5
The preparation method of the Chinese medicine composition supplying Fish to eat is as follows:
1) each medical material is taken by following quality: Cortex Phellodendri 17g, Radix Et Rhizoma Rhei 20g, Radix Scutellariae 13g, Herba Silybi mariani 16g, Folium Mori 8g, Semen Cuscutae 8g, Radix Gentianae 8g, Fructus Lycii 3g, Radix Codonopsis 6g, Radix Bupleuri 7g, Herba Taraxaci 6g, Radix Astragali 9g, Radix Glycyrrhizae 4g, Semen Cassiae 7g, Fructus Foeniculi 10g, Cortex cinnamomi japonici (Ramulus Cinnamomi) 10g;
2) by Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Semen Cuscutae, Folium Mori, Radix Codonopsis, Radix Glycyrrhizae and the rear 100 DEG C of distilled water extraction 70min altogether of Radix Bupleuri cleaning, repeatedly extract each 35min of secondary, filtered while hot, by extracting liquid filtering simmer down to thick paste, pulverize after being cooled to room temperature, cross 60 mesh sieves;
3) Herba Silybi mariani, Radix Gentianae, Fructus Lycii, Herba Taraxaci, the Radix Astragali, Semen Cassiae, Fructus Foeniculi, Cortex cinnamomi japonici (Ramulus Cinnamomi) are made after super micron mill is pulverized the micropowder of granularity 60 μm, moisture≤8%, and after micropowder is mixed homogeneously with thick paste stirring, add the 0.5-2 pharmaceutic adjuvant doubly of the gross mass of thick paste and described micropowder, make granule finally by vacuum spray drying process.
Experimental example 1
The product that obtained by embodiment of the present invention 1-2 does following experiment: with fourth mandarin fish and Ctenopharyngodon idellus for experimental subject, fourth mandarin fish, the Ctenopharyngodon idellus of suffering from Fatty Liver Disease are respectively first group and second group as blank group; Adopt that antibiotic medicine matched group (antibiotic medicine adopts the enrofloxacin powder in Aquatic product) treatment suffers from the fourth mandarin fish of Fatty Liver Disease, Ctenopharyngodon idellus is respectively the 3rd group, the 4th group; Adopt the experimental group of formula of the present invention to treat and suffer from fourth mandarin fish, the Ctenopharyngodon idellus of Fatty Liver Disease, what use embodiment 1 to treat fourth mandarin fish and Ctenopharyngodon idellus is respectively the 5th group, the 6th group; What use embodiment 2 to treat fourth mandarin fish and Ctenopharyngodon idellus is respectively the 7th group, the 8th group, and carry out feeding experiment, be all mixed in hello piscivorous feedstuff by the medicine of antibiotic and the embodiment of the present invention simultaneously.Test the content of each index such as cholesterol (CHOL), triglyceride (TG) in each experimental group fish serum of different time detecting after starting, and test experience sashimi (raw fish) long pointer, hepatic pathology section etc., go forward side by side line item, physical record the results are shown in shown in following table 1:
Table 1 index result of variations synopsis
Data as can be seen from table 1, the Chinese medicine composition of the embodiment of the present invention respond well, than adopt antibiotic can more effective treatment Fish Fatty Liver Disease, therefore this law invents this formula is worth application energetically to use, a kind of rare product especially for raiser.
Experimental example 2
With fourth mandarin fish and Ctenopharyngodon idellus for experimental subject, be divided into the preliminary study that five groups are carried out phagostimulating effect at random.Do not let alone the blank group of what medicament as first group, commercially available phagostimulant " only medicine " highly enriched phagostimulant (comparative example 1) is as second group, by the formula of the embodiment of the present invention 3 with 8%, 5%, 2% addition join respectively in foundation bait, as the 3rd group, the 4th group and four or five groups, the number of times of attracting room and blank room is entered with maze test record test fish, and test fish stings the number of times pecking bait ball, analyze the phagostimulating effect of different Chinese herbal medicine to fourth osmanthus and Ctenopharyngodon idellus.Duration of test water temperature is 22-24 DEG C.Result shows: this formula is to fourth osmanthus and the good phagostimulating effect of Ctenopharyngodon idellus tool (P<0.05).The addition of Chinese herbal medicine formula is different, and phagostimulating effect is also different.Wherein: the phagostimulating effect of addition to fourth osmanthus of 5% Chinese herbal medicine is best; The phagostimulating effect of addition to Ctenopharyngodon idellus of 8% Chinese herbal medicine is best, and it is not remarkable with the difference of commercially available phagostimulant " only medicine " highly enriched phagostimulant, illustrate that the Chinese medicine composition being used for the treatment of fatty,fiss hepatopathy of the present invention not only has effect of curing the disease, and its phagostimulating effect is good, effect can compare favourably with conventional phagostimulant in prior art, and concrete outcome sees the following form 2.
The comparison (secondary/min) of table 2 pair fourth mandarin fish and Ctenopharyngodon idellus phagostimulating effect
Although illustrate and describe the present invention with specific embodiment, however it will be appreciated that can to make when not deviating from the spirit and scope of the present invention many other change and amendment.Therefore, this means to comprise all such changes and modifications belonged in the scope of the invention in the following claims.
Claims (10)
1., for the Chinese medicine composition that Fish are edible, it is characterized in that, it forms primarily of following component: in mass fraction, Cortex Phellodendri 10-20 part, Radix Et Rhizoma Rhei 10-30 part, Radix Scutellariae 10-20 part, Herba Silybi mariani 10-20 part, Folium Mori 5-10 part, Semen Cuscutae 5-10 part, Radix Gentianae 5-10 part, Fructus Lycii 2-5 part, Radix Codonopsis 3-10 part, Radix Bupleuri 5-10 part, Herba Taraxaci 3-10 part, Radix Astragali 5-20 part, Radix Glycyrrhizae 2-8 part, Semen Cassiae 2-10 part, Fructus Foeniculi 5-15 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 5-20 part.
2. the Chinese medicine composition edible for Fish according to claim 1, it is characterized in that, described component comprises: in mass fraction, Cortex Phellodendri 12-18 part, Radix Et Rhizoma Rhei 12-24 part, Radix Scutellariae 11-14 part, Herba Silybi mariani 15-18 part, Folium Mori 7-9 part, Semen Cuscutae 7-9 part, Radix Gentianae 8-9 part, Fructus Lycii 3-4 part, Radix Codonopsis 4-8 part, Radix Bupleuri 6-9 part, Herba Taraxaci 4-8 part, Radix Astragali 7-10 part, Radix Glycyrrhizae 3-5 part, Semen Cassiae 3-8 part, Fructus Foeniculi 8-12 part, Cortex cinnamomi japonici (Ramulus Cinnamomi) 7-15 part.
3. the Chinese medicine composition edible for Fish according to claim 2, it is characterized in that, described component comprises: in mass fraction, Cortex Phellodendri 17 parts, Radix Et Rhizoma Rhei 20 parts, Radix Scutellariae 13 parts, Herba Silybi mariani 16 parts, 8 parts, Folium Mori, Semen Cuscutae 8 parts, Radix Gentianae 8 parts, Fructus Lycii 3 parts, Radix Codonopsis 6 parts, Radix Bupleuri 7 parts, Herba Taraxaci 6 parts, the Radix Astragali 9 parts, 4 parts, Radix Glycyrrhizae, Semen Cassiae 7 parts, Fructus Foeniculi 10 parts, 10 parts, Cortex cinnamomi japonici (Ramulus Cinnamomi).
4. the Chinese medicine composition edible for Fish according to any one of claim 1-3, it is characterized in that, described component also comprises: in mass fraction, Semen Sesami 5-10 part.
5. the Chinese medicine composition edible for Fish according to claim 4, it is characterized in that, the mass fraction of its Semen Sesami is 7 parts.
6. the preparation method of the Chinese medicine composition supplying Fish to eat described in any one of claim 1-5, is characterized in that, comprise the steps:
Cortex Phellodendri, Radix Et Rhizoma Rhei, Radix Scutellariae, Semen Cuscutae, Folium Mori, Radix Codonopsis, Radix Glycyrrhizae and Radix Bupleuri distillation extraction, filtering and concentrating are obtained thick paste, and residue component be ground into micropowder simultaneously, after described thick paste and described micropowder are uniformly mixed, is drying to obtain.
7. the preparation method of the Chinese medicine composition supplying Fish to eat according to claim 6, is characterized in that, controlling total time at 70-90min of distillation extraction, repeatedly extracts 2-3 time.
8. the preparation method of the Chinese medicine composition supplying Fish to eat according to claim 6, it is characterized in that, described thick paste comprises following post processing: pulverize after being cooled to room temperature, crosses the sieve of more than 60 orders.
9. the preparation method of the Chinese medicine composition supplying Fish to eat according to claim 6, it is characterized in that, the granularity control of described micropowder is below 75 μm, and moisture Control is at below 8wt%;
Preferably, after described thick paste and described micropowder being uniformly mixed, and add the 0.5-2 pharmaceutic adjuvant doubly of the gross mass of described thick paste and described micropowder.
10. the Chinese medicine composition supplying Fish to eat described in any one of claim 1-5 is as preparation control fish fats hepatopathy and the application improved in the medicine of feedstuff luring function.
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| CN117461746A (en) * | 2023-12-08 | 2024-01-30 | 欣宇辉生物科技(山东)有限公司 | Production method of aquatic phagostimulant for enzymolysis of fish peptide solution of ocean fish |
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| CN108669382A (en) * | 2018-08-06 | 2018-10-19 | 华南师范大学 | Application of the bupleurum extract as epinephelus feed additive |
| CN108669382B (en) * | 2018-08-06 | 2021-11-09 | 华南师范大学 | Application of bupleurum extract as feed additive for grouper |
| CN117461746A (en) * | 2023-12-08 | 2024-01-30 | 欣宇辉生物科技(山东)有限公司 | Production method of aquatic phagostimulant for enzymolysis of fish peptide solution of ocean fish |
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