CN104887952B - Composition with yin nourishing and lung moistening effects and preparation method and application thereof - Google Patents
Composition with yin nourishing and lung moistening effects and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for nourishing yin, clearing heat, moistening lung and relieving cough and a preparation method thereof, belonging to the field of traditional Chinese medicine modernization. The active ingredients of the traditional Chinese medicine composition for nourishing yin, clearing heat, moistening lung and suppressing cough are prepared from the following raw materials in parts by weight: 1-30 parts of honeysuckle, 1-30 parts of momordica grosvenori, 1-20 parts of lily, 1-20 parts of Chinese yam, 1-10 parts of dark plum, 1-10 parts of polygonatum odoratum, 1-10 parts of mung bean, 1-10 parts of peach kernel and 1-10 parts of almond. The traditional Chinese medicine composition disclosed by the invention is prepared from medicinal and edible varieties according to a traditional Chinese medicine theory and a syndrome differentiation theory, so that the effect of preventing and treating lung diseases is achieved, the quality is stable and controllable, the curative effect is remarkably improved compared with that of the conventional commercially available dosage forms, the administration dosage of a patient is reduced, the bioavailability is improved, and the traditional Chinese medicine composition has remarkable economic and social benefits.
Description
Technical Field
The invention relates to a medicine, in particular to a composition with the effects of nourishing yin and moistening lung, a preparation method and application thereof.
Background
Present society, because of automobile exhaust discharges, industrial gas discharges, numerous factors such as coal-fired and volatile organic compounds lead to the haze to produce, seriously endanger human health, PM2.5 (the diameter is less than or equal to 2.5 microns in the atmosphere particulate matter also is called into lung particulate matter) that contains in the haze can directly get into bronchus and alveolus and be absorbed by the human body, lead to: (1) inhaled micro-dust can impair the oxygen transport capacity of hemoglobin, causing various diseases; (2) the dust particles entering the alveolus can be absorbed rapidly, and the harmful substances can enter the blood circulation without being detoxified by the liver; (3) diseases of the immune system and the blood system including asthma, bronchitis and the like may be caused. Bronchitis, asthma, cough and the like caused by diseases such as pulmonary infection and the like can be converted into chronic diseases if the treatment is not timely, and the daily work and life of patients are seriously influenced.
The traditional Chinese medicine considers that the lung is a delicate organ, and the warm pathogen is attacked first. The lung is the organ most vulnerable to foreign harmful substances. From the angle of nourishing yin and moistening lung in the traditional Chinese medicine, a dietary therapy method is adopted, the immunity is improved, harmful substances are eliminated, and the effects of moistening lung, expelling toxin and preventing lung discomfort are achieved.
The components of the invention are all derived from the homologous varieties of medicine and food, wherein the honeysuckle is sweet and slightly cold, and has the effects of detoxifying and removing heat and soothing throat; fructus momordicae clears heat and moistens lung, relieves sore throat and makes sound; the lily is sweet and cool, has the effects of nourishing yin and moistening the lung, and clearing away the heart fire and soothing the nerves; chinese yam has the effects of tonifying lung, relieving cough, invigorating spleen and tonifying stomach; dark plum fruit has the effects of promoting the production of body fluid to quench thirst, astringing lung to relieve cough; yuzhu has effects of nourishing yin, moistening dryness, promoting fluid production and relieving cough; mung beans are sweet and cold, clear away heat and toxic materials, relieve restlessness and quench thirst; peach kernel and apricot kernel can relieve cough and dyspnea. The composition has the effects of clearing heat and removing toxicity, clearing and moistening throat, and clearing and moistening lung deficiency, so that the lung can clear, descend, tonify qi and yin, and harmonize mind, and the composition has the effects of tonifying deficiency and damage of five internal organs.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to solve the defects of the prior art, provides the composition for nourishing yin and moistening lung, which has scientific and reasonable proportion, definite curative effect and safe clinical use, and also aims to provide a preparation method of the composition and application of the composition in preparation of medicines for treating lung diseases.
The technical scheme is as follows: in order to achieve the above purpose, the invention adopts the technical scheme that:
a composition with yin nourishing and lung moistening effects is prepared from the following raw materials in parts by weight: 1-30 parts of honeysuckle, 1-30 parts of momordica grosvenori, 1-20 parts of lily, 1-20 parts of Chinese yam, 1-10 parts of dark plum, 1-10 parts of polygonatum odoratum, 1-10 parts of mung bean, 1-10 parts of peach kernel and 1-10 parts of almond.
As a preferred scheme, the composition with the effects of nourishing yin and moistening lung is prepared from the following raw materials in parts by weight: 1-10 parts of honeysuckle, 1-10 parts of momordica grosvenori, 1-5 parts of lily, 1-5 parts of Chinese yam, 1-3 parts of dark plum, 1-3 parts of polygonatum odoratum, 1-3 parts of mung bean, 1-3 parts of peach kernel and 1-3 parts of almond.
As a more preferable scheme, the composition with the effects of nourishing yin and moistening lung is prepared from the following raw materials in parts by weight: 10 parts of honeysuckle, 10 parts of momordica grosvenori, 5 parts of lily, 5 parts of Chinese yam, 3 parts of dark plum, 3 parts of polygonatum odoratum, 3 parts of mung bean, 1 part of peach kernel and 1 part of almond.
More preferably, the composition with yin nourishing and lung moistening effects is prepared by the following method: weighing the raw materials according to the raw material ratio, taking honeysuckle, momordica grosvenori, lily, Chinese yam, dark plum and polygonatum odoratum, crushing, adding 8-12 times of water for extraction for 1-3 times, 2-3 hours each time, combining the filtrates to obtain a water extract, centrifuging, collecting a supernatant, concentrating until the relative density is 1.03-1.10 to obtain a concentrated solution, and drying under reduced pressure or spray drying to obtain an extracted dry matter; micronizing semen Phaseoli Radiati, semen Persicae, and semen Armeniacae amarum, and mixing with the dry extract to obtain composition with yin nourishing and lung moistening effects.
According to the traditional Chinese medicine theory, the traditional Chinese medicine formula provided by the invention adopts syndrome differentiation treatment, the compatibility formula is determined through a large number of experiments, and the extract is prepared by the optimal method, so that the compatibility is scientific and reasonable, and the traditional Chinese medicine formula has good effects of nourishing yin and moistening lung.
The composition with the effects of nourishing yin and moistening lung provided by the invention can be prepared into oral liquid, granules, capsules, tablets and pills by using the extracts of all the raw material medicines and pharmaceutically acceptable carriers.
When the extract of the composition provided by the invention is prepared into capsules, the extract of each raw material is uniformly mixed with the mung bean powder, the peach kernel powder and the almond powder, and then the mixture is packaged into capsules to prepare the capsules.
When the extracts of the raw materials of the composition provided by the invention are prepared into tablets, the extracts of the raw materials are uniformly mixed with the powder of mung beans, peach kernels and almonds, the granules are sized, the lubricant magnesium stearate is added if necessary, and then the tablets are prepared by tabletting.
When the extracts of the raw materials of the composition provided by the invention are prepared into granules, the extracts of the raw materials are uniformly mixed with mung bean, peach kernel and almond powder, and then the granules are prepared after the granules are sized and dried.
The preparation method of the composition with the effects of nourishing yin and moistening lung provided by the invention comprises the following steps:
(1) crushing honeysuckle, momordica grosvenori, lily, Chinese yam, dark plum and polygonatum odoratum, adding 8-12 times of water for extraction for 1-3 times, 2-3 hours each time, combining filtrates to obtain a water extract, and concentrating until the relative density is 1.03-1.10 to obtain a concentrated solution for later use;
(2) taking mung beans, peach kernels and almonds, and micronizing for later use;
(3) mixing the extract obtained in step (1) and the micro powder obtained in step (2) according to the weight parts, and preparing the mixture with pharmaceutically acceptable carriers into granules, capsules, tablets and pills.
Preferably, in the preparation method of the composition with yin nourishing and lung moistening effects, the extraction method in the step (1) is a decoction method, a reflux extraction method or a percolation method.
Has the advantages that: compared with the prior art, the composition provided by the invention has the following advantages:
the traditional Chinese medicine composition is screened by adopting the theory of treatment based on syndrome differentiation according to the traditional Chinese medicine theory, the composition proportion is scientific and reasonable, and the experimental result shows that the composition provided by the invention has the effects of nourishing yin, moistening dryness, clearing and nourishing throat, and clearing and moistening lung deficiency. In addition, the extract of the composition provided by the invention can be conveniently prepared into various dosage forms with a pharmaceutical carrier, and is convenient to take clinically, and experimental results show that the composition provided by the invention is safe to use and has no toxic or side effect after long-term use. Meanwhile, the preparation method of the compound traditional Chinese medicine preparation provided by the invention has the advantages of reasonable process design, high content of extracted effective components and strong operability, and is suitable for industrial mass production.
Detailed Description
The present invention is further illustrated by the following examples, which are intended to be purely exemplary and are not intended to limit the scope of the invention, as various equivalent modifications of the invention will occur to those skilled in the art upon reading the present disclosure and fall within the scope of the appended claims.
Example 1
Prescription: 30g of honeysuckle, 30g of momordica grosvenori, 20g of lily, 20g of Chinese yam, 10g of dark plum, 10g of polygonatum odoratum, 10g of mung bean, 10g of peach kernel and 10g of almond.
The preparation method comprises the following steps: decocting all the medicinal materials respectively with 10 times and 8 times of water for 2 hours each time, combining the extracting solutions, drying under reduced pressure at the temperature of 55-60 ℃, concentrating until the relative density is 1.03 to obtain a concentrated solution, spray drying to obtain an extracted dry matter, and encapsulating to prepare capsules.
Example 2
Prescription: 20g of honeysuckle, 20g of momordica grosvenori, 10g of lily, 10g of Chinese yam, 5g of dark plum, 5g of polygonatum odoratum, 3g of mung bean, 3g of peach kernel and 3g of almond.
The preparation method comprises the following steps: taking honeysuckle, momordica grosvenori, lily, Chinese yam, dark plum and polygonatum odoratum according to the prescription amount, decocting and extracting twice with 8 times of water for 1.5h each time, combining the extracting solutions, filtering, collecting the supernatant, concentrating, cooling the concentrated solution, adding 95% ethanol, standing overnight until the ethanol concentration is 70%, filtering, taking the supernatant, drying under reduced pressure at the temperature of 50-55 ℃ to obtain an extract 1; taking mung beans, peach kernels and almonds according to the prescription amount, decocting and extracting the mung beans, the peach kernels and the almonds twice with 8 times of water for 2 hours each time, combining extracting solutions, filtering, collecting supernate, drying the supernate under reduced pressure at the temperature of 55-60 ℃ to obtain an extract 2, uniformly mixing the extract 1 and the extract 2, adding a diluent lactose or corn starch, uniformly mixing, granulating, drying and preparing into granules.
Example 3
Prescription: 30g of honeysuckle, 20g of momordica grosvenori, 20g of lily, 20g of Chinese yam, 10g of dark plum, 10g of polygonatum odoratum, 5g of mung bean, 5g of peach kernel and 5g of almond.
The preparation method comprises the following steps: taking honeysuckle, momordica grosvenori, lily, Chinese yam, dark plum and polygonatum odoratum according to the prescription amount, respectively decocting and extracting the honeysuckle, the momordica grosvenori, the lily, the Chinese yam, the dark plum and the polygonatum odoratum by using 12 times and 10 times of water for 2 hours each time, combining extracting solutions, drying under reduced pressure at the temperature of 55-60 ℃, concentrating until the relative density is 1.03 to obtain a concentrated solution, and performing spray drying to obtain an extracted dry matter 1; taking mung beans, peach kernels and almonds according to the prescription amount, carrying out superfine grinding, mixing with the extract dry matter 1, carrying out wet granulation by 70% ethanol, carrying out size stabilization, adding the lubricant magnesium stearate, uniformly mixing, and then tabletting to prepare tablets.
Example 4
Prescription: 30g of honeysuckle, 30g of momordica grosvenori, 10g of lily, 10g of Chinese yam, 10g of dark plum, 10g of polygonatum odoratum, 8g of mung bean, 6g of peach kernel and 6g of almond.
The preparation method comprises the following steps: taking honeysuckle, momordica grosvenori, lily, Chinese yam, dark plum and polygonatum odoratum according to the prescription amount, decocting and extracting twice with 12 times of water for 2 hours each time, combining the extracting solutions, filtering, collecting the supernatant, concentrating, cooling the concentrated solution, adding 95% ethanol, standing overnight until the ethanol concentration is 70%, filtering, taking the supernatant, drying under reduced pressure at the temperature of 50-55 ℃ to obtain an extract 1; taking mung beans, peach kernels and almonds according to the prescription amount, carrying out superfine grinding, uniformly mixing with the extract 1, carrying out granulation, drying and preparing into pills.
Example 5
Prescription: 30g of honeysuckle, 30g of momordica grosvenori, 10g of lily, 10g of Chinese yam, 10g of dark plum, 10g of polygonatum odoratum, 8g of mung bean, 6g of peach kernel and 6g of almond.
The preparation method comprises the following steps: decocting all the medicinal materials with 12 times of water for 3 hours each time, combining the extracting solutions, drying under reduced pressure at the temperature of 55-60 ℃, concentrating until the relative density is 1.03 to obtain a concentrated solution, adding a flavoring agent, and preparing into oral liquid.
Example 6: effect of the extracts of the invention on anti-inflammatory action in mice
Materials and methods
Animals: half of Kunming mouse, 18-22g of body weight, clean grade, provided by Nanjing medical university laboratory animal center, and generating license SCXK (Su) 2008-;
xylene (batch number: 20110427): jindongtianzheng fine chemical reagent factory, Tianjin;
aspirin (batch number: 20140820): nanjing Baijing pharmaceutical Limited liability company;
effect of p-xylene on mouse auricle swelling: 60 Kunming mice with the weight of 18-22g are taken, the male and female parts are divided into 6 groups randomly, the stomach is irrigated according to the table 1, the stomach is irrigated for 1 time/d for 7 days continuously, the high dose (6.0g crude drug/kg), the medium dose (3.0g crude drug/kg) and the low dose (1.0g crude drug/kg) of the extract for nourishing yin and moistening lung (prepared by the method of the embodiment 5) are given, the aspirin dose is 50mg/kg, and the stomach irrigation volume is 0.2ml/10 g. After sampling for 30min after the last administration on the day, 20. mu.l of xylene was applied to the right auricle of the mouse to cause inflammation, and the animal was sacrificed 2h after the inflammation. The left and right ear of each mouse were then weighed at the same site for differential swelling.
Second, result in
The results are shown in table 1 and show that: compared with the blank control group, the middle and high dose groups of the extract for nourishing yin and moistening lung have significant difference (p is less than 0.05 and p is less than 0.01), which indicates that the extract can reduce the degree of mouse auricle swelling caused by xylene and presents a certain dose dependence relationship, and indicates that the extract has good anti-inflammatory effect.
TABLE 1 Effect of Yin-nourishing and Lung-moistening extracts on swelling of mouse auricle (X + -SD)
P <0.05 compared to blank group; p <0.01
Example 7: influence of the extract of the invention on the effect of the mouse on the phlegm eliminating
Materials and methods
Animals: half of Kunming mouse, 18-22g of body weight, clean grade, provided by Nanjing medical university laboratory animal center, and generating license SCXK (Su) 2008-;
ammonium chloride (batch number: 20130106): tianjin Asia Tailong Xinghu chemical Co., Ltd;
phenol Red (batch No. 20141017), Body chemical Co., Ltd., Tianjin;
UV7504 UV-vis spectrophotometer: shanghai precision instruments Ltd
60 healthy Kunming mice are taken, the weight is 18-22g, the mice are randomly divided into 5 groups, namely a blank group, an ammonium chloride positive control group (0.5g/kg), a high dose (6.0g crude drug/kg), a medium dose (3.0g crude drug/kg) and a low dose (1.0g crude drug/kg) of the extract for nourishing yin and moistening lung (prepared by the method of example 5), except that purified water with the same volume is given to the blank group, other administration groups are continuously administrated by stomach irrigation for 7d according to the administration dose, and the stomach irrigation volume is 0.2ml/10 g. Fasting is carried out for 12h before the last administration, 5% phenol red normal saline solution is injected into the abdominal cavity for 0.5h after the last administration for 10ml/kg, the mouse is killed by breaking the neck after 0.5h, tissues around the trachea are stripped, a section of trachea from the thyroid cartilage to the trachea branch is cut off, the trachea is placed into a test tube containing alkaline normal saline solution, after the test tube is placed for 2h at room temperature, the absorbance of the trachea eluent is measured at 546nm by using an ultraviolet visible spectrophotometer, and the content of the phenol red in the trachea of each mouse is calculated by using a phenol red standard curve. Experimental data were statistically analyzed by variance.
Second, result in
The results are shown in table 2 and show that: compared with a blank control group, the low-dose group of the extract for nourishing yin and moistening lung has significant difference (p is less than 0.05), and compared with the blank control group, the medium-dose group and the high-dose group of the extract for nourishing yin and moistening lung have very significant difference (p is less than 0.01), which indicates that the extract can obviously promote the phenol red excretion amount of mouse trachea and presents a certain dose-effect relationship, and the extract has good phlegm eliminating effect.
TABLE 2 influence of Yin-nourishing and Lung-moistening extract on the expectorant action of mice (X + -SD)
P <0.05 compared to blank group; p <0.01
Example 8: effect of the extract of the present invention on Ammonia-induced cough in mice
Materials and methods
Animals: half of Kunming mouse, 18-22g of body weight, clean grade, provided by Nanjing medical university laboratory animal center, and generating license SCXK (Su) 2008-;
concentrated ammonia (batch: 20130106): tianjin Asia Tailong Xinghu chemical Co., Ltd;
compound Liquorice tablet (batch: 20140910): guangzhou Baiyunshan Guanghua pharmaceutical GmbH;
60 healthy Kunming mice are taken, the weight is 18-22g, the mice are randomly divided into 5 groups, namely a blank group, a compound liquorice tablet positive control group (1.2g/kg), a high dose (6.0g crude drug/kg), a medium dose (3.0g crude drug/kg) and a low dose (1.0g crude drug/kg) of the extract for nourishing yin and moistening lung (prepared by the method of example 5), except that purified water with the same volume is given to the blank group, other administration groups are continuously administrated by intragastric administration for 7 days according to the administration dose, and the intragastric volume is 0.2ml/10 g. Each group was placed in an inverted 500ml beaker 1 hour after the last administration, 0.3ml of concentrated ammonia water was aspirated and injected into a 50mg cotton ball and placed in the beaker, and the cough latency and the number of times of cough in 3 minutes (typical cough is contraction of abdominal muscle of mouse with mouth enlarged with cough) of each group of mice were observed and recorded, and the experimental data were counted by anova.
Second, result in
The results are shown in table 3, the cough latent period of the middle and high dose groups of the extract for nourishing yin and moistening lung is very different from that of the model control group (p is less than 0.01); compared with a model control group, the frequency of cough in 3 minutes in the middle and high dose groups of the extract has a very significant difference (p is less than 0.01), and the frequency of cough in 3 minutes in the low dose group has a significant difference (p is less than 0.05), so that the extract for nourishing yin and moistening lung can obviously prolong the latency period of the mouse cough induced by ammonia water and reduce the frequency of cough, and the extract has an obvious cough relieving effect.
TABLE 3 Effect of Yin-nourishing and Lung-moistening extracts on Ammonia induced cough in mice (X + -SD)
P <0.05 compared to blank group; p <0.01
Claims (3)
1. A composition with yin nourishing and lung moistening effects is characterized by being prepared from the following raw materials in parts by weight: 30 parts of honeysuckle, 30 parts of momordica grosvenori, 20 parts of lily, 20 parts of Chinese yam, 10 parts of dark plum, 10 parts of polygonatum odoratum, 10 parts of mung bean, 10 parts of peach kernel and 10 parts of almond.
2. The composition with the effects of nourishing yin and moistening lung according to claim 1, wherein the active ingredients are prepared by adopting the following method: weighing the raw materials according to the raw material ratio, wherein honeysuckle, momordica grosvenori, lily, Chinese yam, dark plum and polygonatum are decocted and extracted by water, 8-12 times of water is added for extracting for 1-3 hours each time, the extracting solutions are combined and concentrated to the relative density of 1.03-1.10 to obtain a concentrated solution, and the concentrated solution is dried under reduced pressure or spray dried to obtain an extracted dry matter; pulverizing semen Phaseoli Radiati, semen Persicae and semen Armeniacae amarum, and mixing with the dry extract to obtain composition with yin nourishing and lung moistening effects.
3. The use of the composition with yin nourishing and lung moistening effects of claim 1 in the preparation of a cough-relieving and phlegm-eliminating medicament.
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| CN106072565A (en) * | 2016-07-03 | 2016-11-09 | 陈毅忠 | A kind of preparation method of lung moistening removing toxic substances effervescent tablet |
| CN107279391A (en) * | 2017-07-18 | 2017-10-24 | 佛山瑞匀医疗器械有限公司 | Moistening throat and clearing lung type tea and its manufacture method |
| CN108713720A (en) * | 2018-05-17 | 2018-10-30 | 福建省安溪县苷芝宝食品科技有限公司 | Clearing lung-heat profit autumn honey prolongs slurry and its preparation process |
| CN111388596A (en) * | 2020-03-24 | 2020-07-10 | 湖北虹玮农业有限公司 | Special diet for chronic and intractable cough and restoring vital capacity |
| CN114732128A (en) * | 2022-01-28 | 2022-07-12 | 特康药业集团有限公司 | Application of medicinal and edible composition in food for assisting in relieving chronic obstructive pulmonary disease symptoms, nutritional powder and preparation method of nutritional powder |
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| CN102485263A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司达仁堂制药厂 | Medicinal composition for treating chronic cough of children and its preparation method |
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