CN102485263A - Medicinal composition for treating chronic cough of children and its preparation method - Google Patents
Medicinal composition for treating chronic cough of children and its preparation method Download PDFInfo
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Abstract
Belonging to the field of modernization of traditional Chinese medicines, the invention discloses a medicinal composition for treating chronic cough of children and its preparation method. The active components of the medicinal composition for treating chronic cough of children are prepared by the following raw materials by weight: 400 parts of gypsum, 200 parts of loquat leaves, 200 parts of bamboo shavings, 200 parts of mulberry leaves, 100 parts of rhizoma pinellinae praeparata, 100 parts of tussilago farfara, 100 parts of mulberry bark, 100 parts of semen lepidii, 20 parts of acorus gramineus, 100 parts of pumice (calcined), 50 parts of wrinkled gianthyssop herbs, 100 parts of perilla seeds (stir-fried), 50 parts of honeysuckle stems, 100 parts of bitter apricot kernels (stir-fried), 20 parts of agilawood, 100 parts of stiff silkworms (stir-fried), and 6 parts of ephedra. The medicinal composition of the invention has the advantages of: stable and controllable quality, substantially improved curative effect compared with existing sold preparation forms, reduced taking dosage by patients, enhanced bioavailability, as well as obvious economic and social benefits.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and method for preparing of treating chronic cough in children, belong to modern Chinese traditional medicine field.
Background technology
Chronic cough in children is clinical common disease, with the cough repeatedly the outbreak, prolonged more be not characteristics.Have a strong impact on child's health and growth promoter.Mostly cough is with the lung meridian to be main illness, but has substantial connection with internal organs such as spleen, kidneys, and children's's internal organs are tender and lovely, QI and blood does not fill, and interspaces of skin and muscles being loose is prone to impairing the lung gas after the diseases caused by exogenous pathogenic factor, and chronic cough must cause impairment of both QI and YIN, influences the fortune function of spleen.When clear and rich lungs, the activating the spleen removing dampness.
The traditional Chinese medical science thinks that children's's internal organs are tender and lovely, and lung is defended solid, interspaces of skin and muscles being loose, cold warm can not self-regulated, Yi Beifeng, cold, hot exopathogen invasion and attack are so the exogenous cough is in the majority.Children's is a pure-yang constituent, and the evil back of sense is many from cremating, so heat symptom-complex is many.Children's's the spleen tending to insufficiency usually, diet are not known from joint, dysfunction of the spleen in transportation, it is little that water paddy can not change spermatogenesis, accumulation of food in the stomach and intes tine due to indigestion gathers and wets into expectorant, on store in lung, the air flue that is jammed makes inhibited pulmonary QI, is prone to cause that taste are hot and suffocating, damp and hot living expectorant, thereby the Xuan Fasu that influence lung qi falls, and occur to cough.
The infantile intractable cough ball is the Chinese medicine of at present commercially available a kind of nourishing YIN and clearing away heat lung moistening antitussive, and it is processed by Gypsum Fibrosum, Folium Eriobotryae, Caulis Bambusae In Taenia, Folium Mori, Rhizoma Pinelliae Preparatum, Flos Farfarae, Cortex Mori, Semen Lepidii (Semen Descurainiae), Rhizoma Acori Graminei, Pumex (forging), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum, Bombyx Batryticatus (stir-fry), Herba Ephedrae.But infantile intractable cough ball dispelling wind, analgesic, antitussive, reduce phlegm.Be used for the cough due to lung-heat, copious thick sticky phlegm, non-stop cough and pertussis.
The prescription of infantile intractable cough ball and method for making are: Gypsum Fibrosum 400g, Folium Eriobotryae 200g, Caulis Bambusae In Taenia 200g, Folium Mori 200g, Rhizoma Pinelliae Preparatum 100g, Flos Farfarae 100g, Cortex Mori 100g, Semen Lepidii (Semen Descurainiae) 100g, Rhizoma Acori Graminei 20g, Pumex (forging) 100g, Herba Pogostemonis 50g, Fructus Perillae (stir-fry) 100g, Caulis Lonicerae 50g, Semen Armeniacae Amarum (stir-fry) 100g, Lignum Aquilariae Resinatum 20g, Bombyx Batryticatus (stir-fry) 100g, Herba Ephedrae 6g.With ten seven flavor medicine materials, be ground into fine powder, other gets pear paste (clear paste) 80g and above-mentioned powder is mixed thoroughly, and drying is ground into fine powder, and mixing sieves.Every 100g powder adds refined honey 85～105g and processes big honeyed pills, promptly gets.
Pear paste prescription and method for making are: autumn pear 1000g, bright Rhizoma Nelumbinis 20g, green turnip 10g, Bulbus Fritillariae Thunbergii 10g, Radix Ophiopogonis 10g, Rhizoma Zingiberis Recens 5g.Above Six-element, pears are broken, squeeze or throw away Sucus Pyri, the residue decocting in water is once; Boil liquid and Sucus Pyri and merge, filter, be concentrated into proportion 1.28～1.30 (25 ℃), the chopping of the five tastes such as bright Rhizoma Nelumbinis; The decocting in water secondary is obtained and is boiled liquid, the residue squeezing; Press liquor with boil liquid and merge, filter, be concentrated into relative density 1.28～1.30 (25 ℃).Above-mentioned twice condensed cream merged mixing.Every 500g condensed cream adds refined honey 1500g, is concentrated into relative density 1.38～1.40 (25 ℃), sieves, and fill promptly gets.
This medicine method for making is simple, but former prescription type is a honeyed pill, goes mouldy easily and microbiological contamination, is unfavorable for quality control.The patient takes and carries inconvenience, and mouthfeel is not good, and every ball weighs 3 grams, and every dose of dose is excessive, children's's dysphagia, and patient's acceptance level is poor.And from oral slow to the gastrointestinal absorption process.These factors directly influence infantile intractable cough ball applying clinically.
Summary of the invention
First technical problem that the present invention will solve provides a kind of pharmaceutical composition of treating chronic cough in children.
Another technical problem that the present invention will solve provides manufacturing method for above mentioned medicine.
For realizing above-mentioned purpose, the present invention adopts following technical scheme:
A kind of pharmaceutical composition of treating chronic cough in children, its active component is processed by the raw material of following parts by weight: 400 parts in Gypsum Fibrosum, 200 parts of Folium Eriobotryaes, 200 parts of Caulis Bambusae In Taenia, 200 parts on Folium Mori, 100 parts of Rhizoma Pinelliae Preparatum, 100 parts of Flos Farfaraees, 100 parts of Cortex Mori, 100 parts of Semen Lepidii (Semen Descurainiae)s, 20 parts of Rhizoma Acori Graminei, 100 parts of Pumexs (forging), 50 parts of Herba Pogostemoniss, 100 parts of Fructus Perillaes (stir-fry), 50 parts of Caulis Loniceraes, 100 parts of Semen Armeniacae Amarums (stir-fry), 20 parts of Lignum Aquilariae Resinatum, 100 parts of Bombyx Batryticatus (stir-fry), 6 parts in Herba Ephedrae.
Said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use concentration of volume percent that 6-12 doubly measures to be the ethanol alcohol extraction of 40%-80% 2-3 time; Each 1-3 hour; Merge alcohol extract, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water that 8-12 doubly measures, and each 1-3 hour, merge the water extract, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component of the present invention.
Saidly take by weighing each raw material by proportioning raw materials; Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use concentration of volume percent that 8-10 doubly measures to be the ethanol alcohol extraction of 50%-70% 2-3 time; Each 1-2 hour; Merge alcohol extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water that 8-10 doubly measures, and each 1-2 hour, merge the water extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component of the present invention.
Take by weighing each raw material by proportioning raw materials; It is 60% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 10 times of amounts; Each 1.5 hours; Merge alcohol extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water of 10 times of amounts, and each 1.5 hours, merge the water extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component of the present invention.
Said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
Said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
The dosage form of said Chinese medicine composition is a peroral dosage form, includes but not limited to pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of preparation of drug combination method of treating chronic cough in children takes by weighing 400 parts in Gypsum Fibrosum, 200 parts of Folium Eriobotryaes, 200 parts of Caulis Bambusae In Taenia, 200 parts on Folium Mori, 100 parts of Rhizoma Pinelliae Preparatum, 100 parts of Flos Farfaraees, 100 parts of Cortex Mori, 100 parts of Semen Lepidii (Semen Descurainiae)s, 20 parts of Rhizoma Acori Graminei, 100 parts of Pumexs (forging), 50 parts of Herba Pogostemoniss, 100 parts of Fructus Perillaes (stir-fry), 50 parts of Caulis Loniceraes, 100 parts of Semen Armeniacae Amarums (stir-fry), 20 parts of Lignum Aquilariae Resinatum, 100 parts of Bombyx Batryticatus (stir-fry), 6 parts in Herba Ephedrae; Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use concentration of volume percent that 6-12 doubly measures to be the ethanol alcohol extraction of 40%-80% 2-3 time; Each 1-3 hour; Merge alcohol extract, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water that 8-12 doubly measures, and each 1-3 hour, merge the water extract, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component of the present invention.
Preferred manufacturing procedure is: take by weighing each raw material by proportioning raw materials; Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use concentration of volume percent that 8-10 doubly measures to be the ethanol alcohol extraction of 50%-70% 2-3 time; Each 1-2 hour; Merge alcohol extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water that 8-10 doubly measures, and each 1-2 hour, merge the water extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component of the present invention.
Most preferred method for preparing is: take by weighing each raw material by proportioning raw materials; It is 60% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 10 times of amounts; Each 1.5 hours; Merge alcohol extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water of 10 times of amounts, and each 1.5 hours, merge the water extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component of the present invention.
Chinese medicine composition that technical scheme of the present invention is related and preparation thereof all have good nourishing YIN and clearing away heat, the effect of lung moistening antitussive, but dispelling wind, analgesic, antitussive, reduce phlegm.Be used for the cough due to lung-heat, copious thick sticky phlegm, non-stop cough and pertussis.Through zoopery, we find that unexpectedly the pharmaceutical composition of prepared of the present invention is compared with former dosage form, have excellent eliminating the phlegm and antitussive effect.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property and the Pharmacological action study result of each flavour of a drug ingredient, research has obtained the method for preparing of reasonable, stable active component.Adopt technical scheme of the present invention, prepared pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, bioavailability improves, have remarkable economical and social benefit.
Below specify technical scheme of the present invention through embodiment, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: the preparation Chinese medicine extract
One. prescription: Gypsum Fibrosum 400g, Folium Eriobotryae 200g, Caulis Bambusae In Taenia 200g, Folium Mori 200g, Rhizoma Pinelliae Preparatum 100g, Flos Farfarae 100g, Cortex Mori 100g, Semen Lepidii (Semen Descurainiae) 100g, Rhizoma Acori Graminei 20g, Pumex (forging) 100g, Herba Pogostemonis 50g, Fructus Perillae (stir-fry) 100g, Caulis Lonicerae 50g, Semen Armeniacae Amarum (stir-fry) 100g, Lignum Aquilariae Resinatum 20g, Bombyx Batryticatus (stir-fry) 100g, Herba Ephedrae 6g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 60% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 10 times of amounts, 8 times of amounts; Each 2 hours; Merge alcohol extract, be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2 times with the water water of 10 times of amounts, and each 2 hours, merge the water extract, be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component 772 grams of the present invention.
Embodiment 2: the preparation Chinese medicine extract
One. prescription: Gypsum Fibrosum 400g, Folium Eriobotryae 200g, Caulis Bambusae In Taenia 200g, Folium Mori 200g, Rhizoma Pinelliae Preparatum 100g, Flos Farfarae 100g, Cortex Mori 100g, Semen Lepidii (Semen Descurainiae) 100g, Rhizoma Acori Graminei 20g, Pumex (forging) 100g, Herba Pogostemonis 50g, Fructus Perillae (stir-fry) 100g, Caulis Lonicerae 50g, Semen Armeniacae Amarum (stir-fry) 100g, Lignum Aquilariae Resinatum 20g, Bombyx Batryticatus (stir-fry) 100g, Herba Ephedrae 6g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 70% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 8 times of amounts, 6 times of amounts; Each 1.5 hours; Merge alcohol extract, be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug waters are carried 2 times, extract 2 hours with 10 times of water gagings for the first time, and for the second time with 8 times of water gagings extractions 1.5 hours, merging water extract is concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtains concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component 980 grams of the present invention.
Embodiment 3: the preparation Chinese medicine extract
One. prescription: Gypsum Fibrosum 400g, Folium Eriobotryae 200g, Caulis Bambusae In Taenia 200g, Folium Mori 200g, Rhizoma Pinelliae Preparatum 100g, Flos Farfarae 100g, Cortex Mori 100g, Semen Lepidii (Semen Descurainiae) 100g, Rhizoma Acori Graminei 20g, Pumex (forging) 100g, Herba Pogostemonis 50g, Fructus Perillae (stir-fry) 100g, Caulis Lonicerae 50g, Semen Armeniacae Amarum (stir-fry) 100g, Lignum Aquilariae Resinatum 20g, Bombyx Batryticatus (stir-fry) 100g, Herba Ephedrae 6g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 60% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 10 times of amounts; Each 1.5 hours; Merge alcohol extract, be concentrated into that relative density is 1.06 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water of 10 times of amounts, and each 1.5 hours, merge the water extract, be concentrated into that relative density is 1.06 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component 786 grams of the present invention.
Embodiment 4: the preparation Chinese medicine extract
One. prescription: Gypsum Fibrosum 400g, Folium Eriobotryae 200g, Caulis Bambusae In Taenia 200g, Folium Mori 200g, Rhizoma Pinelliae Preparatum 100g, Flos Farfarae 100g, Cortex Mori 100g, Semen Lepidii (Semen Descurainiae) 100g, Rhizoma Acori Graminei 20g, Pumex (forging) 100g, Herba Pogostemonis 50g, Fructus Perillae (stir-fry) 100g, Caulis Lonicerae 50g, Semen Armeniacae Amarum (stir-fry) 100g, Lignum Aquilariae Resinatum 20g, Bombyx Batryticatus (stir-fry) 100g, Herba Ephedrae 6g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 40% ethanol alcohol extraction 3 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 12 times of amounts; Each 3 hours; Merge alcohol extract, be concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 3 times with the water water of 12 times of amounts, and each 3 hours, merge the water extract, be concentrated into that relative density is 1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component 830 grams of the present invention.
Embodiment 5: the preparation Chinese medicine extract
One. prescription: Gypsum Fibrosum 400g, Folium Eriobotryae 200g, Caulis Bambusae In Taenia 200g, Folium Mori 200g, Rhizoma Pinelliae Preparatum 100g, Flos Farfarae 100g, Cortex Mori 100g, Semen Lepidii (Semen Descurainiae) 100g, Rhizoma Acori Graminei 20g, Pumex (forging) 100g, Herba Pogostemonis 50g, Fructus Perillae (stir-fry) 100g, Caulis Lonicerae 50g, Semen Armeniacae Amarum (stir-fry) 100g, Lignum Aquilariae Resinatum 20g, Bombyx Batryticatus (stir-fry) 100g, Herba Ephedrae 6g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 80% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 6 times of amounts; Each 1 hour; Merge alcohol extract, be concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2 times with the water water of 8 times of amounts, and each 1 hour, merge the water extract, be concentrated into that relative density is 1.03 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component 845 grams of the present invention.
Embodiment 6: the preparation Chinese medicine extract
One. prescription: Gypsum Fibrosum 400g, Folium Eriobotryae 200g, Caulis Bambusae In Taenia 200g, Folium Mori 200g, Rhizoma Pinelliae Preparatum 100g, Flos Farfarae 100g, Cortex Mori 100g, Semen Lepidii (Semen Descurainiae) 100g, Rhizoma Acori Graminei 20g, Pumex (forging) 100g, Herba Pogostemonis 50g, Fructus Perillae (stir-fry) 100g, Caulis Lonicerae 50g, Semen Armeniacae Amarum (stir-fry) 100g, Lignum Aquilariae Resinatum 20g, Bombyx Batryticatus (stir-fry) 100g, Herba Ephedrae 6g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 50% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 10 times of amounts, 12 times of amounts; Each 2.5 hours; Merge alcohol extract, be concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2 times with the water water of 10 times of amounts, and each 2.5 hours, merge the water extract, be concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component 770 grams of the present invention.
Embodiment 7: the preparation Chinese medicine extract
One. prescription: Gypsum Fibrosum 400g, Folium Eriobotryae 200g, Caulis Bambusae In Taenia 200g, Folium Mori 200g, Rhizoma Pinelliae Preparatum 100g, Flos Farfarae 100g, Cortex Mori 100g, Semen Lepidii (Semen Descurainiae) 100g, Rhizoma Acori Graminei 20g, Pumex (forging) 100g, Herba Pogostemonis 50g, Fructus Perillae (stir-fry) 100g, Caulis Lonicerae 50g, Semen Armeniacae Amarum (stir-fry) 100g, Lignum Aquilariae Resinatum 20g, Bombyx Batryticatus (stir-fry) 100g, Herba Ephedrae 6g.
Two. method for making:
Take by weighing each raw material by proportioning raw materials; It is 60% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 10 times of amounts; Each 1.5 hours; Merge alcohol extract, be concentrated into that relative density is 1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2 times with the water water of 10 times of amounts, and each 1.5 hours, merge the water extract, be concentrated into that relative density is 1.05 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I, is active component 790 grams of the present invention.
Embodiment 8: the preparation granule
The active component 100g that embodiment 1 obtains, with sucrose 50g, lactose 20g, citric acid 2g, the system granule gets granule, every packed 6g.
Embodiment 9: the preparation granule
The active component 100g that embodiment 2 obtains adds xylitol 50g, lactose 20g, and citric acid 2g, aspartame 0.1g makes granule, gets granule, every packed 5g.
Embodiment 10: zoopery one: extract of the present invention is to the influence of mice phlegm-dispelling functions
One. material and method
Infantile intractable cough ball (lot number: 090625), reach core hall pharmaceutical factory by new Pharmaceutical limited company in the Tianjin and produce
Animal: the ICR mice is provided credit number by Beijing Vital River Experimental Animals Technology Co., Ltd.: SCXK (capital) 2002-0003.
Ammonium chloride (lot number: 20090327), dragon Xinghua, Asia-Pacific, Tianjin worker's company limited
Phenol red (lot number: 20081546), rich Dihua, Tianjin worker's company limited
UV7504 ultraviolet-uisible spectrophotometer: Shanghai precision instrument company limited
Get 60 of healthy ICR mices, body weight 18～22g is divided into 5 groups at random; Be blank control group, ammonium chloride positive controls (0.5g/kg), infantile intractable cough extract (press embodiment 2 methods preparation) is low, high dose group (1.5,3.0g crude drug/kg); Infantile intractable cough ball group (the 3.0g crude drug/kg); Except that blank control group gave isopyknic pure water, all by the continuous gastric infusion of above-mentioned dosage 7 days, the administration volume was 20ml/kg to other administration groups.Fasting 12h before the last administration; 0.5 hour lumbar injection 5% phenol red normal saline solution 10ml/kg after the last administration; 0.5 disconnected neck is put to death mice after hour, peels off the trachea surrounding tissue, cuts from one section trachea of thyroid cartilage to trachea bifurcation; Put into the test tube that fills alkaline normal saline (normal saline 2ml+1N sodium hydroxide 0.1ml) solution; After room temperature is placed 2 hours, the trachea eluent is surveyed its absorbance with ultraviolet-uisible spectrophotometer in the 546nm wavelength, calculate every phenol red content of mice trachea through phenol red standard curve.Experimental data is added up with variance analysis.
Two. result: see table 1.
The table 1 extract administration influence to the mice phlegm-dispelling functions in seven days
Compare * P＜0.05 with the blank group, * * P＜0.01 and infantile intractable cough ball group are than #P＜0.05
The result shows: the infantile intractable cough extract is low, high dose group and blank group relatively; Utmost point significant difference (P＜0.01) is all arranged; The phenol red excretion amount of pointing out this extract can obviously promote the mice trachea, and present certain dose-effect relationship, explain that this invention extract has good phlegm-dispelling functions.Under Isodose, the infantile intractable cough extract compares with former dosage form under Isodose, and significant difference (P＜0.05) is arranged, and points out extract phlegm-dispelling functions of the present invention to be superior to former dosage form.
Embodiment 11: zoopery two: extract of the present invention causes the influence of mouse cough to ammonia
One. material and method:
Infantile intractable cough ball (lot number 090867), reaching core hall pharmaceutical factory by new Pharmaceutical limited company in the Tianjin provides.
FUFANG GANCAO PIAN (lot number 090119) Tianjin Lisheng Pharmaceutical Co., Ltd.
Strong aqua ammonia: chemical reagent work is learned in Dongli District safe blue Dehua in Tianjin
Animal: the ICR mice is provided credit number by Beijing Vital River Experimental Animals Technology Co., Ltd.: SCXK (capital) 2002-0003.
Get 60 of healthy ICR mices, body weight 18～22g is divided into 5 groups at random; Be blank control group, FUFANG GANCAO PIAN positive controls (0.5g/kg), infantile intractable cough extract (press embodiment 2 methods preparation) is low, high dose group (3.0,6.0g crude drug/kg); (the 3.0g crude drug/kg), except that blank control group gave isopyknic pure water, the positive drug FUFANG GANCAO PIAN was in experiment administration on the same day 1 time for infantile intractable cough ball group; All by the continuous gastric infusion of above-mentioned dosage 7 days, the administration volume was 20ml/kg to other administration groups.Each organizes after the last administration 1 hour; Mice is placed in the inverted 500ml beaker; Draw and to put into beaker after the 0.3ml strong aqua ammonia injects the 50mg cotton balls, observe and the cough latent period of mice respectively organized in record and in 3 minutes the mouse cough number of times (typical case's cough is that the mice abdominal muscle shrinks, and magnifies mouth simultaneously; With coughing sound), experimental data is added up with variance analysis.
Two. result: see table 2.
Table 2 extract successive administration caused the influence
of mouse cough in seven days to ammonia
With model control group relatively, * P＜0.05, * * P＜0.01 and infantile intractable cough ball group are than #P＜0.05
The result shows: extract is low, the cough latent period of high dose group has utmost point significant difference (P＜0.01) with the model control group ratio, and other each administration groups and model control group are than there are no significant difference.Extract is low, the number of times and the model control group of cough relatively has utmost point significant difference (P＜0.01) in the high dose group 3 minutes; Prompting is 3.0, under 6.0g crude drug/kg dosage, and the infantile intractable cough extract can obviously prolong ammonia inductive mouse cough incubation period and reduce the cough number of times.Infantile intractable cough is got thing under Isodose all has significant difference (P＜0.05) with former dosage form ratio to cough latent period and to the influence of the number of times of cough in 3 minutes, explains that this extract has tangible antitussive effect and effect to be superior to former dosage form.
Claims (10)
1. pharmaceutical composition of treating chronic cough in children, it is characterized in that: its active component is processed by the raw material of following parts by weight: 400 parts in Gypsum Fibrosum, 200 parts of Folium Eriobotryaes, 200 parts of Caulis Bambusae In Taenia, 200 parts on Folium Mori, 100 parts of Rhizoma Pinelliae Preparatum, 100 parts of Flos Farfaraees, 100 parts of Cortex Mori, 100 parts of Semen Lepidii (Semen Descurainiae)s, 20 parts of Rhizoma Acori Graminei, 100 parts of Pumexs (forging), 50 parts of Herba Pogostemoniss, 100 parts of Fructus Perillaes (stir-fry), 50 parts of Caulis Loniceraes, 100 parts of Semen Armeniacae Amarums (stir-fry), 20 parts of Lignum Aquilariae Resinatum, 100 parts of Bombyx Batryticatus (stir-fry), 6 parts in Herba Ephedrae.
2. a kind of pharmaceutical composition of treating chronic cough in children according to claim 1 is characterized in that said active component adopts following method to prepare: take by weighing each raw material by proportioning raw materials; Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use concentration of volume percent that 6-12 doubly measures to be the ethanol alcohol extraction of 40%-80% 2-3 time; Each 1-3 hour; Merge alcohol extract, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water that 8-12 doubly measures, and each 1-3 hour, merge the water extract, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I.
3. a kind of pharmaceutical composition of treating chronic cough in children according to claim 2 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use concentration of volume percent that 8-10 doubly measures to be the ethanol alcohol extraction of 50%-70% 2-3 time; Each 1-2 hour; Merge alcohol extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water that 8-10 doubly measures, and each 1-2 hour, merge the water extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I.
4. a kind of pharmaceutical composition of treating chronic cough in children according to claim 3 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; It is 60% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 10 times of amounts; Each 1.5 hours; Merge alcohol extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water of 10 times of amounts, and each 1.5 hours, merge the water extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I.
5. according to any one described a kind of pharmaceutical composition of treating chronic cough in children in the claim 1 to 4, it is characterized in that: said pharmaceutical composition also contains the pharmaceutics acceptable auxiliary.
6. a kind of pharmaceutical composition of treating chronic cough in children according to claim 5 is characterized in that: said pharmaceutics acceptable auxiliary is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, sodium carboxymethyl cellulose, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and the sodium sulfite.
7. a kind of pharmaceutical composition of treating chronic cough in children according to claim 5, it is characterized in that: the dosage form of said Chinese medicine composition is a peroral dosage form, comprises pill, tablet, capsule or oral liquid.
8. a preparation of drug combination method of treating chronic cough in children is characterized in that: take by weighing 400 parts in Gypsum Fibrosum, 200 parts of Folium Eriobotryaes, 200 parts of Caulis Bambusae In Taenia, 200 parts on Folium Mori, 100 parts of Rhizoma Pinelliae Preparatum, 100 parts of Flos Farfaraees, 100 parts of Cortex Mori, 100 parts of Semen Lepidii (Semen Descurainiae)s, 20 parts of Rhizoma Acori Graminei, 100 parts of Pumexs (forging), 50 parts of Herba Pogostemoniss, 100 parts of Fructus Perillaes (stir-fry), 50 parts of Caulis Loniceraes, 100 parts of Semen Armeniacae Amarums (stir-fry), 20 parts of Lignum Aquilariae Resinatum, 100 parts of Bombyx Batryticatus (stir-fry), 6 parts in Herba Ephedrae; Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use concentration of volume percent that 6-12 doubly measures to be the ethanol alcohol extraction of 40%-80% 2-3 time; Each 1-3 hour; Merge alcohol extract, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water that 8-12 doubly measures, and each 1-3 hour, merge the water extract, be concentrated into that relative density is 1.03-1.10 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I.
9. a kind of preparation of drug combination method of treating chronic cough in children according to claim 8 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use concentration of volume percent that 8-10 doubly measures to be the ethanol alcohol extraction of 50%-70% 2-3 time; Each 1-2 hour; Merge alcohol extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water that 8-10 doubly measures, and each 1-2 hour, merge the water extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I.
10. a kind of preparation of drug combination method of treating chronic cough in children according to claim 8 is characterized in that: saidly take by weighing each raw material by proportioning raw materials; It is 60% ethanol alcohol extraction 2 times that Semen Lepidii (Semen Descurainiae), Herba Pogostemonis, Fructus Perillae (stir-fry), Caulis Lonicerae, Semen Armeniacae Amarum (stir-fry), Lignum Aquilariae Resinatum use the concentration of volume percent of 10 times of amounts; Each 1.5 hours; Merge alcohol extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution A; All the other flavour of a drug are carried 2-3 time with the water water of 10 times of amounts, and each 1.5 hours, merge the water extract, be concentrated into that relative density is 1.05-1.08 under the 50-60 ℃ of condition, obtain concentrated solution B; Concentrated solution A, B are mixed, and drying obtains dry thing I.
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| CN103007023A (en) * | 2012-12-17 | 2013-04-03 | 李淑玲 | External traditional Chinese medicine composition for treating cough variant asthma of adult |
| CN104887952A (en) * | 2015-05-07 | 2015-09-09 | 南京中医药大学 | Composition possessing effects of yin nourishing and lung moistening, preparation method and application thereof |
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| CN1203885C (en) * | 2003-03-06 | 2005-06-01 | 曹明成 | Chinese medicines for infantile cough and asthma and their preparations |
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| CN1368263A (en) * | 2001-02-06 | 2002-09-11 | 杨孟君 | Nano medicine for treating infantile intractable cough and its preparing process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103007023A (en) * | 2012-12-17 | 2013-04-03 | 李淑玲 | External traditional Chinese medicine composition for treating cough variant asthma of adult |
| CN103007023B (en) * | 2012-12-17 | 2015-03-11 | 李淑玲 | External traditional Chinese medicine composition for treating cough variant asthma of adult |
| CN104887952A (en) * | 2015-05-07 | 2015-09-09 | 南京中医药大学 | Composition possessing effects of yin nourishing and lung moistening, preparation method and application thereof |
| CN104887952B (en) * | 2015-05-07 | 2020-07-24 | 南京中医药大学 | Composition with yin nourishing and lung moistening effects and preparation method and application thereof |
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