CN103007023B - External traditional Chinese medicine composition for treating cough variant asthma of adult - Google Patents
External traditional Chinese medicine composition for treating cough variant asthma of adult Download PDFInfo
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Abstract
The invention provides an external traditional Chinese medicine composition for treating cough variant asthma of an adult. The external traditional Chinese medicine composition uses perillaseed and cynanchum glaucescens as a monarch medicine, uses radish seed, flos farfarae, fritillaria and the root bark of white mulberry as a ministerial medicine, uses agilawood as an adjuvant medicine and uses liquorice as a conductant medicine. The external traditional Chinese medicine composition has a reasonable receipt, and uses a traditional acupoint therapy and a transdermal absorption principle in modern pharmacy. The traditional Chinese medicine composition provided by the invention is respectively adhered to a Tiantu acupoint, Feishu acupoints at the both sides, a Dingchuan acupoint, a Fenglong acupoint and a Shenshu acupoint of a human body, so as to treat the cough variant asthma of the adult. Particularly, according to the specific therapy of winter disease cured in summer in a traditional Chinese medicine, the acupoints are adhered in dog days. A dosing method is simple and convenient; the medicinal effect is reliable and lasting; and no untoward effect exists. The external traditional Chinese medicine composition has the functions of conducting through channels and collaterals, tonifying yang, dispersing in-vivo severe pathogenic cold, reducing phlegm in a temper manner, inspiring healthy atmosphere of the human body, supporting the healthy energy, and preventing and treating the diseases. The treatment cost is low. The total efficiency is 88.7%. The external traditional Chinese medicine composition provided by the invention is an effective medicine for treating the cough variant asthma of the adult.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of external medicine composition for the treatment of adult's cough variant asthma.
Background technology
Cough variant asthma is also known as cough type asthma, atypia asthma, conceal type asthma, a kind of asthma of specific type, with air flue chronic nonspecific inflammation, airflow obstruction and airway hyperreactivity for feature, be main or unique symptom with chronic cough, mostly occur in night or morning, owing to there is no unified diagnosis, treatment standard at present, be easily misdiagnosed as bronchitis or chronic pharyngitis, widely apply antibiotic therapy less effective.At present, its pathogenesis is illustrated not yet completely.Treatment aspect, conventional medicine has bronchodilator, adrenocortical hormone, LTRA etc., though there is certain curative effect, but the course for the treatment of is longer, easily repeatedly, long term systemic medication or local application's inhalant, side effect is can hardly be avoided, therefore, finding the Therapeutic Method that a kind of curative effect is high, stable, lasting, toxic and side effects is little, is the practical challenges of pendulum in face of medical personnel.Use traditional Chinese medical science unique theoretical system, play the advantage of Chinese medicine, treatment adult cough variant asthma, has very important clinical meaning current.
Though cough variant asthma is without definite names of disease of tcm, according to its dry cough, few symptom such as expectorant, itching throat, the features such as chronic delay, obstinate refractory and recurrent exerbation, can belonged to " cough " category.No matter Exogenous and internal injuries, cough the disease being located in the lung.Lung being a delicate viscus, is subject to inside and outside heresy invasion and attack and is disease; A surname is respectful not normal for the disease being located in the lung, abnormal rising of lung-QI.But cough does not terminate in lung, and not higher than lung, be attributed to evil visitor in lung.Pathological factor is based on expectorant, and the generation of expectorant is relevant with lung spleen renal dysfunction.Lung governing qi, has adjustment whole body mechanism of qi, the effects such as compress body fluid and regulating fluid apssage, and with the passing of time, water liquid can not normal defeated cloth for pneumonopathy, poly-and be drink, and then become expectorant, lung be the device storing up expectorant; The spleen has the function to transport and transform nutrients, and water wets, dysfunction of the spleen in transportation, retention of water-damp in the body, gathers and forms expectorant, the spleen being the source of producing phlegm; The kidney being a water ZANG-organ, the normal defeated cloth of water liquid depends on the gasification transpiration of kidney, if water liquid of suffering from a deficiency of the kidney is not changed, then coagulates and forms expectorant, and therefore, the dirty malfunction of lung spleen kidney three all can cause " raw in phlegm retention ".During treatment, except directly controlling except lung, also should, from entirety, note controlling spleen, controlling kidney.
Summer dog days, nature yang-energy is vigorous, human body space between skin and muscles using pungent drugs for dispersion and bitter drugs for purgation, Rong Wei is sensible, lies prostrate the evil legibility of the YIN-cold retained phlegm in lung, simultaneously, space between skin and muscles using pungent drugs for dispersion and bitter drugs for purgation, drug absorption is rapid, the efficacy of a drug be easy to reach deep internal organs and play therapeutical effect (Cui fetes doctor. newly add mustard pungent cream acupoint application treatment catabasis asthma 500 example [J] dog days. Journal of Traditional Chinese Medicine, 2009,50 (5): 438-439.).According to the theory of " taking good care of YANG in spring and summer ", " correspondence between man and universe ", in dog days in summer, the yang-energy of human body obtains sky sun help, " two sun are added ", the yang-energy of temperature compensation human body, yang-energy is contained, and phlegm retention is gone, disease spontaneous remission (Mu Xiaohua, Shen Ning, Qiu Mengru. treating winter disease in summer acupoint application treatment catabasis of bronchitis asthma clinical observation [J]. Shandong Traditional Chinese Medicine University's journal, 2009,33 (6): 502-503.).
Summary of the invention
In order to the Chinese medicine of abundant treatment cough variant asthma, the invention provides a kind of external medicine composition for the treatment of cough variant asthma.
A kind of external medicine composition for the treatment of adult's cough variant asthma provided by the invention, composition and the mass ratio of its formula are as follows: the mass ratio of Fructus Perillae, Rhizoma Cynanchi Stauntonii, Semen Raphani, Flos Farfarae, Bulbus Fritillariae Uninbracteatae, Cortex Mori, Lignum Aquilariae Resinatum and Radix Glycyrrhizae is 3:3:2:2:2:2:1:2.
Fructus Perillae and Rhizoma Cynanchi Stauntonii are monarch drug.Fructus Perillae returns lung meridian, has lowering the adverse-rising QI to resolve phlegm, the merit of relieving cough and asthma, and this product is longer than lowering the adverse-rising QI to resolve phlegm, and " herbal classic is met former " is sayed: Fructus Perillae " the performance therapeutic method to keep the adverse QI flowing downwards, therefore the unfavorable person of chest and diaphragm should it ... for coughing except diprophylline, pleasant good dose of expectorant ".
Rhizoma Cynanchi Stauntonii returns lung meridian, there is the effect of lowering the adverse-rising QI to resolve phlegm, be longer than and eliminate the phlegm, fall lung qi, no matter genus is cold belongs to heat, Exogenous and internal injuries all available it, with lung qi lose the person of falling be advisable, Compendium of Material Medica say: Rhizoma Cynanchi Stauntonii is " the lunar medicine of hands is also ", be longer than sending down the abnormal ascending QI, lung qi is stopped up real and has expectorant person should it, and modern pharmacological research Saponin contained by it has phlegm-dispelling functions, gas fall expectorant disappear then cough with asthma from flat.
Semen Raphani, Flos Farfarae, Bulbus Fritillariae Uninbracteatae, Cortex Mori are ministerial drug.Semen Raphani " therapeutic method to keep the adverse QI flowing downwards Dingchuan, controls expectorant ... ".See Compendium of Material Medica.Semen Raphani and Fructus Perillae with the use of, strengthen the effect of expectorant cough suppressant and anti-asthmatic, modern pharmacological research shows that Semen Raphani water extract has certain antiinflammatory action simultaneously.
The cough-relieving of Flos Farfarae moistening the lung and resolving phlegm.Flos Farfarae is cough-relieving common medicine, can be used for multiple cough." herbal classic is met former " is sayed: Flos Farfarae " lung moistening expectorant, relieving cough, relieving asthma ", its water decoction of modern pharmacological research has antitussive effect in animal experiment.
Bulbus Fritillariae Uninbracteatae is reduced phlegm, nourishing the lung to arrest cough." book on Chinese herbal medicine converge with speech " speech: " Bulbus Fritillariae Uninbracteatae, dissipating depression of QI, the medicine that the therapeutic method to keep the adverse QI flowing downwards is reduced phlegm also, lung moistening expectorant, cough-relieving ... Bulbus Fritillariae Uninbracteatae specially takes charge of first dose "; Modern pharmacological research fritillaria total alkaloids and non-alkaloid part, all have antitussive effect simultaneously.
Aqueous vapor in Cortex Mori eliminating the pathogens from the lung." property of medicine opinion " is sayed: Cortex Mori " controlling lung qi dyspnea with fullness of the chest ... ".Lung qi is able to respectful clearly, and cough with dyspnea is from flat; Above four medicines share, the cough-relieving of principal drug assistance lowering the adverse-rising QI to resolve phlegm.
Help pungent using warming therapy Lignum Aquilariae Resinatum less.Lignum Aquilariae Resinatum has the effect that circulation of qi promoting is relievingd asthma, and generation and the lung spleen kidney of phlegm retention are in close relations, sick phlegm retention person when with warm medicine and it, Lignum Aquilariae Resinatum is warm in nature, returns taste, kidney channel, and with its loose YIN-cold in the heart, temperature is reduced phlegm drink, while principal drug assistance improving inspiration by invigorating kidney-QI cough-relieving.
Radix Glycyrrhizae, nourishing the lung to arrest cough, coordinating the actions of various ingredients in a prescription, for making medicine.Modern pharmacological research shows, its main component enoxolone has obvious central antitussive effect.
All medicines share and gas can be made to fall expectorant disappear and cough only.With Mel coordinating the actions of various ingredients in a prescription.Containing multiple enzyme and mineral in Mel, body immunity can be improved, enhancing body resistance against diseases; Research simultaneously finds that Mel has certain antibacterial and anti-inflammation functions.
Described external medicine composition is used for external use in acupoint coating, is conducted, rouse oneself human body, disperse YIN-cold in body by meridians, temperature is reduced phlegm drink, strengthening the body resistance, treatment cough variant asthma of preventing and curing diseases.Especially, theoretical with Chinese medicine meridian and " during sky solar term " traditional Chinese medical science time theory is guidance, the negative and positive complied with the nature change, treating winter disease in summer, by described external medicine composition, in the dog days that nature yang-energy is contained most, external use in acupoint is adopted to stick, according to People of the same tastes and habits like to be together, inspire human righteousness, strengthening the body resistance, prevents and cures diseases, and treatment cough variant asthma has more special efficacy.
Treating winter disease in summer is a kind of therapy shown unique characteristics of Chinese medicine.Utilize the yang-energy of " dog days " nature Sheng in a year, body QI and blood be vigorous, opportune time of " two sun are harmonious " of space between skin and muscles using pungent drugs for dispersion and bitter drugs for purgation, carry out stimulating acupoint by external application Chinese medicine, unimpeded meridians, QI and blood regulating, can make YIN and YANG in a relative equilibrium, and chronic disease can be cured or alleviate.Adopt the most flower point-application of Chinese medicine composition nature in dog days yang-energy, treatment cough variant asthma, the disease prevention of the Overall View and " prevention of diseae " that fully demonstrate the traditional Chinese medical science " harmony between man and nature " is seen, and resides in preventing in controlling, and control takes into account, and is the characteristic of the present invention.
The external medicine composition external for the treatment of adult cough variant asthma provided by the invention sticks following acupuncture point: TIANTU acupoint, bilateral FEIYU acupoint, DINGCHUAN acupoint, Fenglong acupoint, SHENYU acupoint.
TIANTU acupoint is ren meridian points, is one of master point for the treatment of cough with asthma." Yulong's song " day: " card of asthma is the most unbearable, and night, the wonderful cave of Tiantu should be sought without sleeping gas in a hurry ... ", conception vessel enters throat, and drug effect can dredge throat and lung system QI and blood in Tiantu, sending down the abnormal ascending QI cough-relieving; Meanwhile, get FEIYU acupoint and eliminate the phlegm with lung qi dispersing, treating both the principal and the secondary aspects of a disease at the same time; DINGCHUAN acupoint is the effect cave of relieving cough and asthma, and Fenglong acupoint is the specific acupoint that eliminates the phlegm, and Papillary strengthens the effect of expelling phlegm for arresting cough.The kidney being the root of QI, the congenital foundation, therefore get SHENYU acupoint element culturing fixed folder to receive kidney qi; SHENYU acupoint is again the acupuncture points on the human body of bladder meridian, the table of the main the whole body of urinary bladder channel, change through gas, affect the respectful of lung and fall a surname, shen shu is one of shu-back point simultaneously, shu-back point be qi of zang-fu viscera infusion in the acupuncture point of body surface, can better play medicine to internal organs, meridians, qi-blood-body fluid Accommodation.
A kind of using method for the treatment of the external medicine composition of cough variant asthma provided by the invention is as follows: the external medicine composition for the treatment of adult cough variant asthma is ground into powder, add Mel and mix well into pasty state, even application is in medically acceptable strile gauze dressing, stick in human body TIANTU acupoint respectively, bilateral FEIYU acupoint, DINGCHUAN acupoint, Fenglong acupoint, SHENYU acupoint, indwelling was taken off after 4 hours.At every turn concrete consumption as described in Example 1.Within 7 days, be a course for the treatment of, treat 3 courses for the treatment of continuously.
Or, respectively at one volt of the Chinese lunar calendar, second of the three ten-day periods of the hot season, dog days the first seven day 5 time-9 time stick in human body TIANTU acupoint, bilateral FEIYU acupoint, DINGCHUAN acupoint, Fenglong acupoint, SHENYU acupoint, indwelling was taken off after 4 hours.At every turn concrete consumption as described in Example 1.Within 7 days, be a course for the treatment of, treat 3 courses for the treatment of continuously.
Taboo: this Chinese medicine composition skin allergy person is forbidden.
diagnostic criteria:diagnostic criteria is formulated with reference to " proposing of global asthma control " (GINA) (the 1998 U.S. National Institutes hearts, lung, Blood Research Institute).Basic diagnosis condition: (1) cough continues or recurrent exerbation more than 1 month, common early morning and (or) night-time attack cough, motion or cold air stimulate postemphasis; (2) clinical nothing of having a medical check-up infects positive sign, invalid through long-term antibiotic therapy; (3) bronchodilator, glucocorticoid can make coughing fit alleviate, but recurrence in the short time after drug withdrawal.Auxiliary diagnosis condition: (1) a guy's allergies or family's allergies; (2) air flue is high response feature.Get rid of the chronic cough that other reasons causes.
criterion of therapeutical effect:with symptom score of coughing for criterion of therapeutical effect.According to patient's cough symptom of 24 hours, contrast score-sheet: carry out judging and record, total score value=score at score+night in the daytime.
The score value of score-sheet is as follows:
0 point: without cough.
2 points: paroxysmal cough in the morning; Cough when night falls asleep, or cause waking up with a start 1 time or early awakening because coughing.
4 points: frequently cough in the daytime, but do not affect routine work; Nocturnal cough causes frequently waking up with a start, and impact is had a rest, but still can adhere to routine work.
6 points: frequently cough in the daytime, affect routine work; Night, hacking cough, can not fall asleep, and impact is had a rest, routine work.
Total effects is judged, integration * 100% before curative effect index (n)=(before treating the rear integration of integration-treatment)/treatment according to nimodipine method.
Clinical cure: cough symptom disappears completely or substantially disappears, n >=95%;
Effective: cough symptom is obviously improved, 70%≤n < 95%;
Effective: cough symptom take a favorable turn, 30%≤n < 70%;
Invalid: cough symptom is without improvement or increase the weight of, n < 30%.
Treatment case and therapeutic effect statistics: according to mentioned above principle, use Drug therapy cough variant asthma Patients with 300 Cases clinical case of the present invention, wherein, man 158 example, female 142 example; 18 ~ 70 years old age.One the course for the treatment of administration time be 7 days, continuously 3 courses for the treatment of of treatment.
Treatments period, does not use other relieving cough and resolving phlegm, spasmolytic suppressing panting calming medicine.
Recovery from illness and obvious effective rate 27.7%, recovery from illness 31 example, effective 52 examples; Totally 83 people, man 44 example, female 39 example.
Effective percentage is 61 %; Totally 183 people, man 97 example, female 86 example.
Invalid is 11.3%; Totally 34 people, man 17 example, female 17 example.
Total effective rate is recovery from illness and obvious effective rate+effective percentage.Total effective rate is for being 88.7 %.
beneficial effect:a kind of external medicine composition for the treatment of adult's cough variant asthma provided by the invention, by Fructus Perillae, Rhizoma Cynanchi Stauntonii, Semen Raphani, Flos Farfarae, Bulbus Fritillariae Uninbracteatae, Cortex Mori, Lignum Aquilariae Resinatum, Radix Glycyrrhizae prescription.Fructus Perillae and Rhizoma Cynanchi Stauntonii are monarch drug, and Semen Raphani, Flos Farfarae, Bulbus Fritillariae Uninbracteatae, Cortex Mori are ministerial drug, help pungent using warming therapy Lignum Aquilariae Resinatum less, and with Radix Glycyrrhizae for making medicine.This Chinese medicine composition reasonable recipe, use Traditional Chinese Medicine acupoint therapy and modern pharmacy Transdermal absorption theory, Chinese medicine composition of the present invention is sticked in human body TIANTU acupoint respectively, bilateral FEIYU acupoint, DINGCHUAN acupoint, Fenglong acupoint, SHENYU acupoint, treatment adult cough variant asthma, clinical efficacy is reliable.And, according to the therapy that the Chinese medicine for the treatment of winter disease in summer shows unique characteristics.Utilize the yang-energy of " dog days " nature Sheng in a year, body QI and blood be vigorous, opportune time of " two sun are harmonious " of space between skin and muscles using pungent drugs for dispersion and bitter drugs for purgation, carry out stimulating acupoint by Traditional Chinese Medicine for external application, unimpeded meridians, QI and blood regulating, can make YIN and YANG in a relative equilibrium, and chronic disease can be cured or alleviate.Adopt the most flower point-application of Chinese medicine composition nature in dog days yang-energy, stick acupuncture point dog days, treatment cough variant asthma, the disease prevention of the Overall View and " prevention of diseae " that fully demonstrate the traditional Chinese medical science " harmony between man and nature " is seen, residence prevents that control takes into account in controlling, and is the characteristic of the present invention.
A kind of external medicine composition medication for the treatment of adult's cough variant asthma provided by the invention is easy, prevents and cures diseases and cost of medical service is cheap.Lasting medicine, has no adverse reaction.Total effective rate is 88.7%.It is a kind of active drug being used for the treatment of adult's cough variant asthma.
Detailed description of the invention
embodiment 1
Treat an external medicine composition for cough variant asthma, its formula is as follows: Chinese medicine Fructus Perillae 3g, Rhizoma Cynanchi Stauntonii 3g, Semen Raphani 2g, Flos Farfarae 2g, Bulbus Fritillariae Uninbracteatae 2g, Cortex Mori 2g, Lignum Aquilariae Resinatum 1g and Radix Glycyrrhizae 2g.
The using method of described Chinese medicine composition is as follows: the Chinese medicine composition of above-mentioned weight is broken into powder, adds Mel and mixes well into pasty state, is placed in 9 respectively medically in acceptable strile gauze dressing, forms diameter 2cm, the Chinese medicine pasty state cake of thick 2mm.Stick respectively in human body TIANTU acupoint, the FEIYU acupoint of bilateral, DINGCHUAN acupoint, Fenglong acupoint and SHENYU acupoint, indwelling was taken off after 4 hours again.Within 7 days, be a course for the treatment of, treat 3 courses for the treatment of continuously.
Or, respectively at one volt of the Chinese lunar calendar, second of the three ten-day periods of the hot season, dog days the first seven day 5 time-9 time spread on human body TIANTU acupoint, the FEIYU acupoint of bilateral, DINGCHUAN acupoint, Fenglong acupoint and SHENYU acupoint, indwelling was taken off after 4 hours.At every turn concrete consumption is described above.Within 7 days, be a course for the treatment of, treat 3 courses for the treatment of continuously.
Taboo: this Chinese medicine composition skin allergy person is forbidden.
diagnostic criteria:diagnostic criteria is formulated with reference to " proposing of global asthma control " (GINA) (the 1998 U.S. National Institutes hearts, lung, Blood Research Institute).Basic diagnosis condition: (1) cough continues or recurrent exerbation more than 1 month, common early morning and (or) night-time attack cough, motion or cold air stimulate postemphasis; (2) clinical nothing of having a medical check-up infects positive sign, invalid through long-term antibiotic therapy; (3) bronchodilator, glucocorticoid can make coughing fit alleviate, but recurrence in the short time after drug withdrawal.Auxiliary diagnosis condition: (1) a guy's allergies or family's allergies; (2) air flue is high response feature.Get rid of the chronic cough that other reasons causes.
criterion of therapeutical effect:with symptom score of coughing for criterion of therapeutical effect.According to patient's cough symptom of 24 hours, contrast score-sheet: carry out judging and record, total score value=score at score+night in the daytime.
The score value of score-sheet is as follows:
0 point: without cough.
2 points: paroxysmal cough in the morning; Cough when night falls asleep, or cause waking up with a start 1 time or early awakening because coughing.
4 points: frequently cough in the daytime, but do not affect routine work; Nocturnal cough causes frequently waking up with a start, and impact is had a rest, but still can adhere to routine work.
6 points: frequently cough in the daytime, affect routine work; Night, hacking cough, can not fall asleep, and impact is had a rest, routine work.
Total effects is judged, integration * 100% before curative effect index (n)=(before treating the rear integration of integration-treatment)/treatment according to nimodipine method.
Clinical cure: cough symptom disappears completely or substantially disappears, n >=95%;
Effective: cough symptom is obviously improved, 70%≤n < 95%;
Effective: cough symptom take a favorable turn, 30%≤n < 70%;
Invalid: cough symptom is without improvement or increase the weight of, n < 30%.
Claims (2)
1. the external medicine composition for the treatment of adult cough variant asthma, it is characterized in that, composition and the mass ratio of its formula are as follows: the mass ratio of Fructus Perillae, Rhizoma Cynanchi Stauntonii, Semen Raphani, Flos Farfarae, Bulbus Fritillariae Uninbracteatae, Cortex Mori, Lignum Aquilariae Resinatum and Radix Glycyrrhizae is 3:3:2:2:2:2:1:2.
2. the external medicine composition for the treatment of adult cough variant asthma as claimed in claim 1, it is characterized in that, composition and the quality of its formula are as follows: Chinese medicine Fructus Perillae 3g, Rhizoma Cynanchi Stauntonii 3g, Semen Raphani 2g, Flos Farfarae 2g, Bulbus Fritillariae Uninbracteatae 2g, Cortex Mori 2g, Lignum Aquilariae Resinatum 1g and Radix Glycyrrhizae 2g.
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| CN104107407A (en) * | 2014-07-01 | 2014-10-22 | 魏本雪 | Traditional Chinese medicine composition for treating infant cold-type asthma |
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