CN102178792B - Shiqi exogenous Chinese medicinal buccal tablets - Google Patents
Shiqi exogenous Chinese medicinal buccal tablets Download PDFInfo
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- CN102178792B CN102178792B CN 201010547779 CN201010547779A CN102178792B CN 102178792 B CN102178792 B CN 102178792B CN 201010547779 CN201010547779 CN 201010547779 CN 201010547779 A CN201010547779 A CN 201010547779A CN 102178792 B CN102178792 B CN 102178792B
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- ilicis asprellae
- radix berchemiae
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Abstract
The invention relates to Chinese medicinal tablets for treating and preventing influenza, which are prepared from the following Chinese medicinal raw materials and a pharmaceutically-acceptable carrier: 245 to 980 grams of holly root, 245 to 980 grams of berchemia lineate, 245 to 980 grams of syzygium jambos, 98 to 392 grams of simple glorybower root and 245 to 980 grams of pandanus tectorius parkins.
Description
Technical field
The invention belongs to the Chinese materia medica field, be specifically related to a kind of grippal traditional Chinese medicine mouth buccal tablet and preparation method thereof for the treatment of and prevent.
Background technology
Flu and influenza are all caused by viral infection.Because virus is via air borne, what therefore stand in the breach is nose.Virus at first infects nasal mucosa, and then constantly breeding causes nasal inflammation, the diseases such as sneeze, rhinorrhea, nasal obstruction occur.General flu refers to coryza, and the impact of human body is only limited to respiratory system usually.All symptoms are all relevant with nose, such as nasal mucus, nasal obstruction and sore throat, cough even fever etc.Just can fully recover after general a couple of days.Influenza is to be caused by influenza virus.Flu-like symptom affects whole body, comprise feel cold, perspiration, systemic pain, headache, osteodynia, myalgia, lassitude and weak, inappetence, cough, nasal obstruction etc., can cause pneumonia and other complication when serious, can be fatal.The characteristic of influenza virus is that polytype is arranged, and just can occur new viral kind about per ten years.Not not viral this concept, is referred to as " exopathogen invasion " without exception for influenza or flu on the Chinese medicine, no matter because viral cradle is nasal mucosa or respiratory tract, all belong to beyond the internal organs, therefore is called " exopathogen ".The traditional Chinese medical science is roughly divided " anemofrigid cold " and " anemopyretic cold " by table note of the ancient Chinese and the somatic reaction classification of disease.Anemopyretic cold symptom: have sore throat, have a fever, have no appetite, rhinorrhea, thick sputum arranged.The anemofrigid cold symptom: the fear of cold aversion to wind, tired, flow clear snot, do not have appetite.
Stone fork diseases caused by exogenous pathogenic factor tea granule, standard number: WS3-B-2672-97, prescription: the smelly dung jasmine of Flos Ilicis Asprellae Radix berchemiae lineatae Jambul Pandanus tectorius (L.) Parkins..Function with cure mainly: wind and heat dispersing, relieving summer-heat and promoting digestion.Be used for the fever and headache that diseases caused by exogenous pathogenic factor cause, dyspepsia is glutted, and the larynx dry tongue is dry, the prevention influenza.Usage and consumption: boiled water is taken after mixing it with water, a 10～20g, 3 times on the one.Specification: every packed 10g.
The raw material of Chinese medicine of stone fork diseases caused by exogenous pathogenic factor tea granule, it derives from:
Pandanus tectorius (L.) Parkins.: Pandanus tectorius Pandanus tectorius Sol. and sibling species thereof;
Radix berchemiae lineatae: Radix berchemiae lineatae Berchemia lineate (Linn.) DC., spend more Radix Berchemiae Giraldianae Berchemia floribunda (Wall.) Brongn., Herba Berchemiae leiocladae Berchemia polyphylla wall.ex Laws.Var.leioclada Hand.-Mazz. and sibling species thereof;
Jambul: Jambul Syzygium jambos (Linn.) Alston and sibling species thereof;
Flos Ilicis Asprellae: Folium Mume Ilicis Purpureae Ilex asprella (Hook.et Arn.) Champ.ex Benth and sibling species thereof;
Smelly dung jasmine: lindley glorybower herb Clerodendrum lindleyi Decne.ex Planch., polyphyll Radix clerodendri fragrantis (Radix Clerodendri Philippini) Clerodendrum philippinum Schauer, Radix clerodendri fragrantis (Radix Clerodendri Philippini) Clerodendrum philippinum Schauer var.simplex Moldenke and sibling species thereof;
Although stone fork diseases caused by exogenous pathogenic factor tea granule has gone on the market for many years, the patient is dissatisfied to its effect, and there is some in main cause: its mouthfeel is bad; Take inconvenience, need boiled water to take after mixing it with water; Stability is bad, and period of storage is short; Detection method is inaccurate, can not ensure drug quality.In addition, because Chinese medicine ingredients is complicated, extraction process is relatively backward, is prone to the FAQs such as moisture absorption, poor fluidity, difficult disintegrate in the preparation, by adding suitable adjuvant, improves technique, can improve quality and the curative effect of Chinese medicine, and enhance productivity.
The present inventor is according to theory of Chinese medical science, and the continuous scientific experiments of process, has invented a kind of grippal traditional Chinese medicine mouth buccal tablet for the treatment of and prevent, and effectively solves and has gone up the problems referred to above.
Summary of the invention
The object of the present invention is to provide a kind of grippal traditional Chinese medicine mouth buccal tablet for the treatment of and prevent.
Traditional Chinese medicine mouth buccal tablet of the present invention is prepared from by following raw material of Chinese medicine and the processing of medicine acceptable carrier:
Flos Ilicis Asprellae 245-980g Radix berchemiae lineatae 245-980g Jambul 245-980g
Smelly dung jasmine 98-392g Pandanus tectorius (L.) Parkins. 245-980g
In the above composition, the weight of medicine is calculated with crude drug, with weight as proportioning, when producing, can proportionally increase or reduce, can be take kilogram as unit such as large-scale production, or take ton as unit, small-scale production also can be take gram or milligram as unit, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and such as serious symptom or light disease, fat or modest patient, the proportioning of the amount that can corresponding adjustment forms increases or reduces being no more than 100%, and drug effect is constant.
Above composition can be made 1000 in tablet of the present invention.
Preferably, traditional Chinese medicine mouth buccal tablet of the present invention is prepared from by following raw material of Chinese medicine and the processing of medicine acceptable carrier:
Flos Ilicis Asprellae 245-980g Radix berchemiae lineatae 245-980g Jambul 245-980g
Smelly dung jasmine 98-392g Pandanus tectorius (L.) Parkins. 245-980g binding agent 10-30g
Correctives 1-200g fluidizer 0.5-50g lubricant 0-20g.
Wherein, described binding agent includes but are not limited to starch, pregelatinized Starch, dextrin, maltodextrin, sucrose, arabic gum, gelatin, methylcellulose, carboxymethyl cellulose, ethyl cellulose, polyvinyl alcohol, Polyethylene Glycol, polyethylene and adjoins pyrrolidone, xanthan gum, hydroxypropyl cellulose and hydroxypropyl emthylcellulose;
Wherein, described correctives includes but are not limited to mannitol, xylitol, steviol glycosides, lactose, fructose, sucrose, protein sugar, maltose alcohol, glycyrrhizin, Sodium Cyclamate, gelatin, aspartame, flavoring banana essence, flavoring pineapple essence, vanillin, fragrant citrus essence, flavoring orange essence, Mint Essence, ginseng essence, citric acid, citric acid;
Wherein, described fluidizer includes but are not limited to micropowder silica gel, Pulvis Talci, Arosil, hydrated sodium aluminosilicate;
Wherein, described lubricant include but are not limited to that cruel, the single Laurel sucrose acid of magnesium stearate, calcium stearate, zinc stearate, glyceryl monostearate, Polyethylene Glycol, hydrogenated vegetable oil, sodium stearyl fumarate, polyoxyethylene monostearate is cruel, sodium laurylsulfate, magnesium laurylsulfate, Stepanol MG and Pulvis Talci.
Further preferred, buccal tablet of the present invention is prepared from by following raw material of Chinese medicine and the processing of medicine acceptable carrier:
Flos Ilicis Asprellae 245-980g Radix berchemiae lineatae 245-980g Jambul 245-980g
Smelly dung jasmine 98-392g Pandanus tectorius (L.) Parkins. 245-980g carboxymethyl cellulose 10-30g
Steviol glycosides 1-200g micropowder silica gel 0.5-50g.
Be more preferably, buccal tablet of the present invention is prepared from by following raw material of Chinese medicine and the processing of medicine acceptable carrier:
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g carboxymethyl cellulose 20g
Steviol glycosides 50g micropowder silica gel 10g.
Other preferably fill a prescription composition in an embodiment the present invention.
Another object of the present invention is to provide the preparation method of buccal tablet of the present invention.
Preparation method of the present invention specifically may further comprise the steps:
Get above Flos Ilicis Asprellae 490g, Radix berchemiae lineatae 490g, Jambul 490g, smelly dung jasmine 196g, Pandanus tectorius (L.) Parkins. 490g decocts with water secondary, each 2 hours, each amount of water is 6 times of medical material amount, and merge extractive liquid, filters, filtrate concentrates the thick paste shape, add above-mentioned adjuvant, drying, the mixing granulation tabletting is made 1000 tablets of tablets.
Special character of the present invention is existing preparation technology is improved, change decocting in water into water boiling and precipitation with ethanol, processing step is: get above five tastes Flos Ilicis Asprellae, Radix berchemiae lineatae, Jambul, smelly dung jasmine and Pandanus tectorius (L.) Parkins., decoct with water secondary, each 2 hours, each amount of water was 6 times of medical material amount, merge extractive liquid,, being concentrated to relative density is 1.10～1.15 (50～60 ℃), adds 95% medicinal alcohol and makes solution contain the alcohol amount to 60-70%, places 12-24 hour, filter, filtrate is concentrated, and drying is ground into fine powder, add adjuvant, the mixing granulation tabletting is made 1000 tablets of tablets.
The non-medicinal component that extraction process by water proposes is more, and the extraction process by water content difference opposite sex is large and hygroscopicity is large; Can disturb the detection of drug standard, can not accurately control drug quality, technique is unstable; The sample of aqueous extraction-alcohol precipitation technology differentiates that Xiang Junneng detects, and active constituent content is higher, and the diversity of content is little, shows that the technology stability behind the precipitate with ethanol is good.
The present invention another preferably to improve be to change decocting in water into wine dipper, described preparation method may further comprise the steps:
Get above five tastes Flos Ilicis Asprellae, Radix berchemiae lineatae, Jambul, smelly dung jasmine and Pandanus tectorius (L.) Parkins., add 95% alcohol reflux secondary, merge extractive liquid, filters, and filtrate is concentrated into without the alcohol flavor, obtain thick paste shape product, add adjuvant, 40 ℃ of drying under reduced pressure 8h, mixing granulation tabletting make 1000 tablets of tablets.
Buccal tablet of the present invention has a therapeutic effect good compared with prior art, few side effects, and instant effect, mouthfeel is good, and the quality guarantee period of medicament phase is long, good stability, cost is low, and preparation technology is simpler, has saved the plurality of advantages such as time of preparation medicine.
The specific embodiment
The invention will be further described by following specific embodiment, but not as limitation of the present invention.
Embodiment 1, buccal tablet
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g carboxymethyl cellulose 20g
Steviol glycosides 50g micropowder silica gel 10g.
Get above five tastes Flos Ilicis Asprellae, Radix berchemiae lineatae, Jambul, smelly dung jasmine and Pandanus tectorius (L.) Parkins. decoct with water secondary, each 2 hours, each amount of water is 6 times of medical material amount, and merge extractive liquid, is concentrated, adding 95% medicinal alcohol is that solution contains the alcohol amount to 70%, places filtration 24 hours, filtrate is concentrated, and drying is ground into fine powder, add adjuvant, mixing granulation is made 1000 tablets of tablets.
Embodiment 2, buccal tablet
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g carboxymethyl cellulose 20g
Steviol glycosides 50g micropowder silica gel 10g.
Get above five tastes Flos Ilicis Asprellae, Radix berchemiae lineatae, Jambul, smelly dung jasmine and Pandanus tectorius (L.) Parkins. with 95% alcohol reflux 2 times, add 10 times of amounts for the first time, reflux, extract, 2 hours is filtered, and medicinal residues add 8 times of amounts for the second time, reflux, extract, 1 hour is filtered merging filtrate, decompression recycling ethanol is to distinguishing the flavor of without alcohol, and merge extractive liquid, filters, it is 1.15-1.20 (60 ℃ of heat are surveyed) thick paste shape that filtrate is concentrated into density, adds the adjuvant mixing granulation and makes 1000 tablets of tablets.
Embodiment 3, Evaluation of Synthetic Effect of Holistic:
Test group: the buccal tablet of the embodiment of the invention 1,2;
Existing granule matched group: stone qi diseases caused by exogenous pathogenic factor granule, Hengsheng Pharmaceutical Co., Ltd., Zhongshan City produces, the accurate word Z44020184 of traditional Chinese medicines.Specification: every packed 10g, lot number: 20071201,
Method: adopt random-blind method, masculine parallel comparison.
The course for the treatment of: 3 days.
Dosage regimen: (1) test group: one time 3,3 times on the one; (2) matched group: one time 2 bags, 3 times on the one.
Result of the test is as follows:
The comprehensive therapeutic effect evaluation criteria
Recovery from illness: treat 3 days normal with interior temperature recovery, the sings and symptoms integration of flu decline 〉=90%;
Produce effects: treat 3 days normal with interior body temperature, the sings and symptoms integration of flu descends 〉=70%,＜90%;
Effectively: treat 3 days with the front reduction of interior body temperature, cold symptoms and somatic feature score decline 〉=30%,＜70%;
Invalid: as to treat and do not fall with interior body temperature in 3 days or raise the sings and symptoms integration of flu＜30%.
Traditional Chinese medical science wind-heat cold Evaluation of Synthetic Effect of Holistic: test group (embodiment of the invention 1) effective percentage 90.13%; (embodiment of the invention 2) effective percentage 87.97%; Existing granule matched group effective percentage 85.29%.
Traditional Chinese medical science flu syndrome of summer-heat-dampness Evaluation of Synthetic Effect of Holistic: test group (embodiment of the invention 1) effective percentage 91.47%; (embodiment of the invention 2) effective percentage 89.25%; Existing granule matched group effective percentage 83.12%.
The tcm syndrome curative effect determinate standard
The therapeutic index computing formula is total mark * 100% (nimodipine method) before (n)=(total mark after total mark before the treatment-treatment)/treatment
Clinical recovery: therapeutic index (integrated value reduction) 〉=95%;
Produce effects: 70%≤therapeutic index (integrated value reduction)＜95%;
Effectively: 30%≤therapeutic index (integrated value reduction)＜70%;
Invalid: therapeutic index (integrated value reduction)＜30%.
Traditional Chinese medical science wind-heat cold therapeutic effect of syndrome is estimated: test group (embodiment of the invention 1) effective percentage 89.43%; (embodiment of the invention 2) effective percentage 89.64%; Existing granule matched group effective percentage 87.39%.
Traditional Chinese medical science flu syndrome of summer-heat-dampness therapeutic effect of syndrome is estimated: test group (embodiment of the invention 1) effective percentage 93.25%; (embodiment of the invention 2) effective percentage 89.25%; Existing granule matched group effective percentage 88.01%.
The curative effect determinate standard of bringing down a fever
Recovery from illness: treat in 24 hours, temperature recovery is normal, and nothing repeatedly;
Produce effects: treat in 24 hours, body temperature reduces more than≤1.0 ℃, but not to normal;
Effectively: treat in 24 hours, body temperature reduces＞0.5＜1.0 ℃, but not to normal;
Invalid: treat in 24 hours, body temperature reduces by 0.5 ℃ of less than.
The curative effect of bringing down a fever (24 hours) compared with the onset time of bringing down a fever
Anemopyretic cold compares: test group (embodiment of the invention 1) curative effect of bringing down a fever (24 hours) effective percentage 82.78%; (embodiment of the invention 2) effective percentage 78.28%; Existing granule matched group effective percentage 75.23%.
Summer-heat damp cold compares: test group (embodiment of the invention 1) curative effect of bringing down a fever (24 hours) effective percentage 81.27%; (embodiment of the invention 2) effective percentage 80.57%, existing granule matched group effective percentage 76.88%.
The therapeutic evaluation of individual event symptom:
Headache: test group (embodiment of the invention 1) effective percentage 90.26%; (embodiment of the invention 2) effective percentage 88.57%, existing granule matched group effective percentage 86.12%.
Feel sick: test group (embodiment of the invention 1) effective percentage 96.23%; (embodiment of the invention 2) effective percentage 80.87%, existing granule matched group effective percentage 89.36%.
Safety evaluatio: the medicine of the embodiment of the invention 1 at the treatment before and after look blood, urine, just routine, liver function, renal function and electrocardiogram, according to safety indexes testing result before and after the test, find newly-increased laboratory checking index abnormal conditions appearance.
Embodiment 4, buccal tablet
Flos Ilicis Asprellae 245g Radix berchemiae lineatae 245g Jambul 245g
Smelly dung jasmine 98g Pandanus tectorius (L.) Parkins. 245g carboxymethyl cellulose 10g
Steviol glycosides 1g micropowder silica gel 0.5g.
Preparation method is selected above-mentioned alcohol extraction or water extraction.
Embodiment 5, buccal tablet
Flos Ilicis Asprellae 980g Radix berchemiae lineatae 980g Jambul 980g
Smelly dung jasmine 392g Pandanus tectorius (L.) Parkins. 980g carboxymethyl cellulose 30g
Steviol glycosides 200g micropowder silica gel 50g.
Preparation method is selected above-mentioned alcohol extraction or water extraction.
Embodiment 6, buccal tablet
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g carboxymethyl cellulose 4g
Steviol glycosides 10g micropowder silica gel 10g
Preparation method is selected above-mentioned alcohol extraction or water extraction.
Embodiment 7, buccal tablet
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g pregelatinized Starch 100g
Aspartame 8g micropowder silica gel 30g
Preparation method is selected above-mentioned alcohol extraction or water extraction.
Embodiment 8, buccal tablet
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g maltodextrin 50g
Aspartame 50g micropowder silica gel 1g
Preparation method is selected above-mentioned alcohol extraction or water extraction.
Embodiment 9, buccal tablet
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g arabic gum 4g
Flavoring pineapple essence 8g Pulvis Talci 1g magnesium laurylsulfate 15g.
Preparation method is selected above-mentioned alcohol extraction or water extraction.
Embodiment 10, buccal tablet
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g arabic gum 4g
Gelatin 8g hydrated sodium aluminosilicate 1g magnesium laurylsulfate 15g.
Preparation method is selected above-mentioned alcohol extraction or water extraction.
Embodiment 11, buccal tablet
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g hydroxypropyl cellulose 6g
Xylitol 12g hydrated sodium aluminosilicate 1g magnesium laurylsulfate 15g.
Preparation method is selected above-mentioned alcohol extraction or water extraction.
Embodiment 12, buccal tablet
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g Polyethylene Glycol 6g
Xylitol 12g hydrated sodium aluminosilicate 1g magnesium laurylsulfate 15g.
Claims (5)
1. stone fork diseases caused by exogenous pathogenic factor traditional Chinese medicine mouth buccal tablet is prepared from by following raw material of Chinese medicine and the processing of medicine acceptable carrier:
Flos Ilicis Asprellae 245-980g Radix berchemiae lineatae 245-980g Jambul 245-980g
Smelly dung jasmine 98-392g Pandanus tectorius (L.) Parkins. 245-980g carboxymethyl cellulose 10-30g
Steviol glycosides 1-200g micropowder silica gel 0.5-50g
Preparation process may further comprise the steps:
Get above five tastes Flos Ilicis Asprellae, Radix berchemiae lineatae, Jambul, smelly dung jasmine and Pandanus tectorius (L.) Parkins. decoct with water secondary, each 2 hours, each amount of water is 6 times of medical material amount, and merge extractive liquid, is in the time of 50～60 ℃, being concentrated to relative density is 1.10～1.15, adds 95% medicinal alcohol and makes solution contain the alcohol amount to 60-70%, places 12-24 hour, filter, filtrate is concentrated, adds adjuvant, the mixing granulation tabletting is made 1000
Perhaps, adopt following preparation method:
Get above five tastes Flos Ilicis Asprellae, Radix berchemiae lineatae, Jambul, smelly dung jasmine and Pandanus tectorius (L.) Parkins., add 95% alcohol reflux secondary, merge extractive liquid, filters, and filtrate is concentrated into without the alcohol flavor, obtain thick paste shape product, add adjuvant, 40 ℃ of drying under reduced pressure 8h, mixing granulation tabletting make 1000.
2. buccal tablet claimed in claim 1 is prepared from by following raw material of Chinese medicine and the processing of medicine acceptable carrier:
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g carboxymethyl cellulose 20g
Steviol glycosides 50g micropowder silica gel 10g.
3. the preparation method of claim 1 or 2 described buccal tablets is characterized in that, may further comprise the steps:
Get above five tastes Flos Ilicis Asprellae, Radix berchemiae lineatae, Jambul, smelly dung jasmine and Pandanus tectorius (L.) Parkins. decoct with water secondary, each 2 hours, each amount of water is 6 times of medical material amount, and merge extractive liquid, is in the time of 50～60 ℃, being concentrated to relative density is 1.10～1.15, adds 95% medicinal alcohol and makes solution contain the alcohol amount to 60-70%, places 12-24 hour, filter, filtrate is concentrated, adds adjuvant, and the mixing granulation tabletting is made 1000.
4. the preparation method of claim 1 or 2 described buccal tablets is characterized in that, may further comprise the steps:
Get above five tastes Flos Ilicis Asprellae, Radix berchemiae lineatae, Jambul, smelly dung jasmine and Pandanus tectorius (L.) Parkins., add 95% alcohol reflux secondary, merge extractive liquid, filters, and filtrate is concentrated into without the alcohol flavor, obtain thick paste shape product, add adjuvant, 40 ℃ of drying under reduced pressure 8h, mixing granulation tabletting make 1000.
5. the preparation method of claim 1 or 2 described buccal tablets is characterized in that, may further comprise the steps:
Flos Ilicis Asprellae 490g Radix berchemiae lineatae 490g Jambul 490g
Smelly dung jasmine 196g Pandanus tectorius (L.) Parkins. 490g carboxymethyl cellulose 20g
Steviol glycosides 50g micropowder silica gel 10g
Get above five tastes Flos Ilicis Asprellae, Radix berchemiae lineatae, Jambul, smelly dung jasmine and Pandanus tectorius (L.) Parkins. with 95% alcohol reflux 2 times, add 10 times of amounts for the first time, reflux, extract, 2 hours is filtered, and medicinal residues add 8 times of amounts for the second time, reflux, extract, 1 hour is filtered merging filtrate, decompression recycling ethanol is to distinguishing the flavor of without alcohol, and merge extractive liquid, filters, 60 ℃ of heat are surveyed, and it is 1.15-1.20 thick paste shape that filtrate is concentrated into density, adds the adjuvant mixing granulation and makes 1000.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010547779 CN102178792B (en) | 2010-11-12 | 2010-11-12 | Shiqi exogenous Chinese medicinal buccal tablets |
| HK11111281.2A HK1156871A1 (en) | 2010-11-12 | 2011-10-20 | A kind of chinese medicinal oral tablets from shiqi against exogenous infection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010547779 CN102178792B (en) | 2010-11-12 | 2010-11-12 | Shiqi exogenous Chinese medicinal buccal tablets |
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| Publication Number | Publication Date |
|---|---|
| CN102178792A CN102178792A (en) | 2011-09-14 |
| CN102178792B true CN102178792B (en) | 2013-01-09 |
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| CN 201010547779 Expired - Fee Related CN102178792B (en) | 2010-11-12 | 2010-11-12 | Shiqi exogenous Chinese medicinal buccal tablets |
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| CN102406690B (en) * | 2011-11-30 | 2014-01-15 | 中山市中智药业集团有限公司 | Traditional Chinese medicine gynostemma pentaphylla buccal tablet |
| CN102406842B (en) * | 2011-11-30 | 2014-03-26 | 中山市中智药业集团有限公司 | Traditional Chinese medicine dendrobium candidum buccal tablets |
| CN106108011A (en) * | 2016-06-25 | 2016-11-16 | 孙凤平 | A kind of water Jambul plant buccal tablet and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181067A (en) * | 2007-12-21 | 2008-05-21 | 郭炳华 | Lactase buccal tablets and preparation method thereof |
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2010
- 2010-11-12 CN CN 201010547779 patent/CN102178792B/en not_active Expired - Fee Related
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181067A (en) * | 2007-12-21 | 2008-05-21 | 郭炳华 | Lactase buccal tablets and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 卫生部.石歧外感茶颗粒.《卫生部颁标准中药成方制剂第14册》.1997,26. * |
| 邱仕君,等.广州地区名老中医用药特点浅析.《新中医》.2009,第41卷(第10期),3-4. * |
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| CN102178792A (en) | 2011-09-14 |
| HK1156871A1 (en) | 2012-06-22 |
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