CN103656137A - Traditional Chinese medicine composition for dispelling wind, relieving heat, stopping cough and resolving phlegm and preparation method thereof - Google Patents
Traditional Chinese medicine composition for dispelling wind, relieving heat, stopping cough and resolving phlegm and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for dispelling wind, relieving heat, stopping cough and resolving phlegm and a preparation method thereof, belonging to the field of modernization of traditional Chinese medicines. The active component of the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 192 parts of tuber pinellia, 96 parts of radix glehniae, 48 parts of Mangnolia officinalis, 192 parts of pummelo pee, 192 parts of peucedanum root, 96 parts of Baikal skullcap root, 96 parts of thunberg fritillary bulb, 48 parts of balloonflower, 96 parts of kudzu root, 96 parts of radix trichosanthis, 96 parts of bitter almond and 0.61 part of perilla leaf oil. The traditional Chinese medicine composition is characterized in that the preparation method of the reasonable and stable active component is obtained according to the research results of physicochemical properties and pharmacological actions of the components contained in the medicines. The medicine disclosed by the invention has the advantages of stable and controllable quality, obviously higher curative effect than the preparation formulations sold in the existing market, and smaller dose taken by the patient. The traditional Chinese medicine composition has obvious economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition that a kind of dispeling wind and relieving fever antitussive reduces phlegm and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
The common cold disease that flu is caused by virus, mixed infection or allergy; Show as part and the General Symptomies such as nasal obstruction, watery nasal discharge, sneeze, cough, pharyngeal discomfort and fear of cold, low grade fever.Wind-chill cold wherein, patient is except having the general symptom such as nasal obstruction, sneeze, cough, headache, also have fear of cold, low grade fever, lossless, myalgia, snivel, tell the features such as thin white expectorant, red swelling and pain of throat, mouthful not thirsty or thirsty desire for hot drinks, white and thin fur, conventionally will wear many clothes or cover large quilt and just feel to settle down.This flu is relevant with patients' feeling wind and cold.
Loose wind relieve coughing syrup is the Chinese medicine that a kind of dispeling wind and relieving fever antitussive of selling in the market reduces phlegm.For pestilent cold, cough due to wind and cold, has a headache lossless, have a stuffy nose low voice speaking, and anemophobia aversion to cold, rhinorrhea with clear discharge, myasthenia of limbs.
Prescription and the method for making of loose wind relieve coughing syrup are: Rhizoma Pinelliae 192g, Radix Glehniae 96g, Cortex Magnoliae Officinalis 48g, Exocarpium Citri Grandis 192g, Radix Peucedani 192g, Radix Scutellariae 96g, Bulbus Fritillariae Thunbergii 96g, Radix Platycodonis 48g, Radix Puerariae 96g, Radix Trichosanthis 96g, Semen Armeniacae Amarum 96g, Folium perillae acutae oil 0.61g.Half summer grade cold water soak, to the saturating heart, adds Rhizoma Zingiberis 16g, decocts with water secondary, filters. and Radix Glehniae decocts with water secondary, filters, and merges above decocting liquid and is concentrated in right amount.Cortex Magnoliae Officinalis 60% ethanol percolate extraction.Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis 60% ethanol percolate extraction, collects first extract 1160ml standby, continues to extract.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract 400ml standby, continues to extract, and merges above ethanol extract and continuous extract, reclaims ethanol and is concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.It is standby that Semen Armeniacae Amarum extracts aqua armeniacae.By above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, the alcoholic solution of aqua armeniacae, Folium perillae acutae oil merges, and mixes, and adds 0.25% ammonia, and adjustment capacity and containing alcohol amount stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merging add simple syrup 640ml (by answer fluid number 20%) stir evenly.Continue standing seven days, adjust total amount to 3200ml.Fill, obtains.
Summary of the invention
First technical problem that the present invention will solve is to provide the Chinese medicine composition that a kind of dispeling wind and relieving fever antitussive reduces phlegm.
Another technical problem that the present invention will solve is to provide the preparation method of above-mentioned Chinese medicine composition.
For achieving the above object, the present invention by the following technical solutions;
The Chinese medicine composition that dispeling wind and relieving fever antitussive reduces phlegm, its active component is made by the raw material of following parts by weight: 192 parts of the Rhizoma Pinelliaes, 96 parts of Radix Glehniaes, 48 parts of Cortex Magnoliae Officinalis, 192 parts of Exocarpium Citri Grandises, 192 parts of Radix Peucedanis, 96 parts of Radix Scutellariaes, 96 parts of Bulbus Fritillariae Thunbergiis, 48 parts of Radix Platycodoniss, 96 parts of Radix Puerariaes, 96 parts of Radix Trichosanthis, 96 parts of Semen Armeniacae Amarums, 0.61 part of Folium perillae acutae oil.
Described active component adopts following method to prepare:
1, by proportioning raw materials, take each raw material; Half summer grade cold water soak, to the saturating heart, adds 16 parts of Rhizoma Zingiberiss, decocts with water secondary, filters. and Radix Glehniae decocts with water secondary, filters, and merges above decocting liquid and is concentrated in right amount.Cortex Magnoliae Officinalis 60% ethanol percolate extraction.Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis 60% ethanol percolate extraction, collects first extract standby, continues to extract.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract standby, continues to extract, and merges above ethanol extract and continuous extract, reclaims ethanol and is concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.It is standby that Semen Armeniacae Amarum extracts aqua armeniacae.By above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, the alcoholic solution of aqua armeniacae, Folium perillae acutae oil merges, and mixes, and adds 0.25% ammonia, and adjustment capacity and containing alcohol amount stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merge.Continue standing seven days, obtain liquids A.
2, by proportioning raw materials, take each raw material; Half summer grade cold water soak, to the saturating heart, adds 16 parts of Rhizoma Zingiberiss, decocts with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, filters; Radix Glehniae decocts with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, filters, and merges above decocting liquid and is concentrated into.8 times of amount 60% ethanol percolate extraction for Cortex Magnoliae Officinalis, 8 times of amount 60% ethanol percolate extraction for Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis, collect the liquid of just filtering standby, and continuation is extracted.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract standby, continues to extract.Merge above ethanol extract and the continuous liquid of filtering, reclaim ethanol and be concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.Semen Armeniacae Amarum deoils, and makes almond cookie, extracts aqua armeniacae standby.Just the filter alcoholic solution of liquid, aqua armeniacae, Folium perillae acutae oil of above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, medical material is merged, mix, add 0.25% ammonia, adjustment capacity and containing alcohol amount, stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merging add simple syrup to stir evenly.Continue standing seven days, obtain liquids A.
Described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
The dosage form of described Chinese medicine composition is peroral dosage form, includes but not limited to pill, tablet, capsule, syrup or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
The preparation method of the Chinese medicine composition that a kind of dispeling wind and relieving fever antitussive reduces phlegm:
Take 192 parts of the Rhizoma Pinelliaes, 96 parts of Radix Glehniaes, 48 parts of Cortex Magnoliae Officinalis, 192 parts of Exocarpium Citri Grandises, 192 parts of Radix Peucedanis, 96 parts of Radix Scutellariaes, 96 parts of Bulbus Fritillariae Thunbergiis, 48 parts of Radix Platycodoniss, 96 parts of Radix Puerariaes, 96 parts of Radix Trichosanthis, 96 parts of Semen Armeniacae Amarums, 0.61 part of Folium perillae acutae oil.Half summer grade cold water soak, to the saturating heart, adds 16 parts of Rhizoma Zingiberiss, decocts with water secondary, filters. and Radix Glehniae decocts with water secondary, filters, and merges above decocting liquid and is concentrated in right amount.Cortex Magnoliae Officinalis 60% ethanol percolate extraction.Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis 60% ethanol percolate extraction, collects first extract standby, continues to extract.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract standby, continues to extract, and merges above ethanol extract and continuous extract, reclaims ethanol and is concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.It is standby that Semen Armeniacae Amarum extracts aqua armeniacae.By above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, the alcoholic solution of aqua armeniacae, Folium perillae acutae oil merges, and mixes, and adds 0.25% ammonia, and adjustment capacity and containing alcohol amount stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merge.Continue standing seven days, obtain liquids A.
Preferred preparation method is: by proportioning raw materials, take each raw material; Half summer grade cold water soak, to the saturating heart, adds 16 parts of Rhizoma Zingiberiss, decocts with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, filters; Radix Glehniae decocts with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, filters, and merges above decocting liquid and is concentrated into.8 times of amount 60% ethanol percolate extraction for Cortex Magnoliae Officinalis, 8 times of amount 60% ethanol percolate extraction for Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis, collect the liquid of just filtering standby, and continuation is extracted.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract standby, continues to extract.Merge above ethanol extract and the continuous liquid of filtering, reclaim ethanol and be concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.Semen Armeniacae Amarum deoils, and makes almond cookie, extracts aqua armeniacae standby.Just the filter alcoholic solution of liquid, aqua armeniacae, Folium perillae acutae oil of above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, medical material is merged, mix, add 0.25% ammonia, adjustment capacity and containing alcohol amount, stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merging add simple syrup to stir evenly.Continue standing seven days, obtain liquids A.
A preparation for the Chinese medicine composition that dispeling wind and relieving fever antitussive reduces phlegm, said preparation adds the acceptable adjuvant of pharmaceutics with above-mentioned active constituents of medicine, makes the acceptable dosage form of pharmaceutics.While utilizing the various dosage form of the required medicine of active fraction preparation of the Chinese medicine composition that the present invention obtains, can be according to the conventional production method preparation in pharmaceutics field.As this active component is mixed with one or more carriers, then make corresponding dosage form.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription to form, and according to the physicochemical property of each flavour of a drug ingredient and pharmacological action, research has obtained the preparation method of reasonable, stable active component.Adopt technical scheme of the present invention, on dutyly gone out pharmaceutical preparation stable and controllable for quality, that curative effect is compared with existing commercially available dosage form and significantly improved, patient's taking dose reduces, there is significant economic and social benefit.
Describe by the following examples technical solution of the present invention in detail, with this, do not limit practical range of the present invention.
The specific embodiment
Embodiment 1: prepare Chinese medicine extract
One, prescription: Rhizoma Pinelliae 192g, Radix Glehniae 96g, Cortex Magnoliae Officinalis 48g, Exocarpium Citri Grandis 192g, Radix Peucedani 192g, Radix Scutellariae 96g, Bulbus Fritillariae Thunbergii 96g, Radix Platycodonis 48g, Radix Puerariae 96g, Radix Trichosanthis 96g, Semen Armeniacae Amarum 96g, Folium perillae acutae oil 0.61g.
Two, method for making:
Half summer grade cold water soak, to the saturating heart, adds Rhizoma Zingiberis 16g, decocts with water secondary, filters. and Radix Glehniae decocts with water secondary, filters, and merges above decocting liquid and is concentrated in right amount.Cortex Magnoliae Officinalis 60% ethanol percolate extraction.Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis 60% ethanol percolate extraction, collects first extract 1160ml standby, continues to extract.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract 400ml standby, continues to extract, and merges above ethanol extract and continuous extract, reclaims ethanol and is concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.It is standby that Semen Armeniacae Amarum extracts aqua armeniacae.By above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, the alcoholic solution of aqua armeniacae, Folium perillae acutae oil merges, and mixes, and adds 0.25% ammonia, and adjustment capacity and containing alcohol amount stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merge.Obtain liquids A and amount to 2560ml.
Embodiment 2: prepare Chinese medicine extract
One, prescription: Rhizoma Pinelliae 96kg, Radix Glehniae 48kg, Cortex Magnoliae Officinalis 24kg, Exocarpium Citri Grandis 96kg, Radix Peucedani 96kg, Radix Scutellariae 48kg, Bulbus Fritillariae Thunbergii 48kg, Radix Platycodonis 24kg, Radix Puerariae 48kg, Radix Trichosanthis 48kg, Semen Armeniacae Amarum 48kg, Folium perillae acutae oil 305g.
Two, method for making:
By proportioning raw materials, take each raw material; Half summer grade cold water soak, to the saturating heart, adds Rhizoma Zingiberis 8kg, decocts with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, filters; Radix Glehniae decocts with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, filters, and merges above decocting liquid and is concentrated into 250,000 ml.8 times of amount 60% ethanol percolate extraction for Cortex Magnoliae Officinalis.8 times of amount 60% ethanol percolate extraction for Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis, collection is just filtered, and 580,000 ml are standby for liquid, continue to extract.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract 200,000 ml standby, continues to extract.Merge above ethanol extract and the continuous liquid of filtering, reclaim ethanol and be concentrated into 300,000 ml.Folium perillae acutae oil dissolves with appropriate amount of ethanol.Semen Armeniacae Amarum deoils, and makes almond cookie 24kg, extracts aqua armeniacae 150,000 ml standby.Just the filter alcoholic solution of liquid, aqua armeniacae, Folium perillae acutae oil of above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, medical material is merged, mix, add ammonia 4000ml, adjustment capacity and containing alcohol amount, stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merging add simple syrup 320,000 ml to stir evenly.Continue standing seven days, adjust total amount to 160 ten thousand ml.
Embodiment 3: prepare syrup
The active component 2560ml that embodiment 1 obtains, adds simple syrup 640ml to stir evenly.Continue standing seven days.Adjust total amount to 3200ml.Bottling, every bottled 10ml.
Embodiment 4: zoopery
One, materials and methods:
Dimethylbenzene, Nanchang flood is reagent chemical plant product all.
Aspirin enteric-coated clothing, Liaohe Pharmaceutical Factory, Shenyang City's product.
Dry yeast, French Lesaffre product.
Loose wind relieve coughing syrup, Longshunrong Pharmaceutical Factory, Tianjin Zhongxin Pharmaceutical Group Co., Ltd's product.
Animal: SD rat, 180-220g, is provided by Beijing Vital River Experimental Animals Technology Co., Ltd., credit number: SCXK (capital) 2002-2003.
Get healthy SD rat, be placed in experimental situation and adapt to 3-4 days, test first 2 days the set time by electric body-temperature instrumentation amount rat anus temperature once, get body temperature meansigma methods at the healthy rat of 37.5-38.5 ℃ for testing.By rat, divide 4 groups at random, and press the volume gavage relative medicine of 10ml/kg body weight.Test is established: matched group (giving normal saline 20ml/kg); Aspirin group; Loose wind relieve coughing extract group,, continuous 4 days.Before experiment in the 4th day, fasting is 12 hours, the same day was surveyed body temperature 3 times in experiment, every 1 hour once, after gavage relative medicine 30 minutes, every rat back subcutaneous injection 15% dry yeast suspension 10ml/kg, respectively at 1,2,4,6,8,9,10 hour survey body temperature after administration once, record and obtain each and measure the moment with respect to the body temperature changing value of normal body temperature, the results are shown in Table 1.
Table one
| Group | Dosage (g/kg) | 1h | 2h | 4h | 6h |
| Matched group | 0.29±0.42 | 0.68±0.61 | 0.81±0.40 | 1.54±0.40 | |
| Aspirin group | 0.3 | 0.12±0.42 | 0.60±0.34 | 0.62±0.38 | 0.19±0.78 |
| Loose wind relieve coughing syrup | 10 | -0.14±0.28 | -0.02±0.32 | 0.17±0.31 | 0.87±0.56 |
| Extract group | 10 | -0.15±0.66 | -0.14±0.41 | 0.01±0.30 | 0.79±0.36 |
Table two
| Group | Dosage (g/kg) | 8h | 9h | 10h |
| Matched group | 1.66±0.52 | 1.88±0.57 | 1.78±0.55 | |
| Aspirin group | 0.3 | 0.24±0.58 | 1.01±0.78 | 1.00±0.71 |
| Loose wind relieve coughing syrup | 10 | 1.12±0.33 | 1.15±0.38 | 1.01±0.42 |
| Extract group | 10 | 1.03±0.41 | 0.90±0.59 | 0.95±0.42 |
Result shows that extract has obvious reduction yeast to cause fever model rat anus temperature, and refrigeration function can be maintained to 10 hours, and effect is better than loose wind relieve coughing syrup.
Claims (8)
1. the Chinese medicine composition that dispeling wind and relieving fever antitussive reduces phlegm, its active component is made by the raw material of following parts by weight: 192 parts of the Rhizoma Pinelliaes, 96 parts of Radix Glehniaes, 48 parts of Cortex Magnoliae Officinalis, 192 parts of Exocarpium Citri Grandises, 192 parts of Radix Peucedanis, 96 parts of Radix Scutellariaes, 96 parts of Bulbus Fritillariae Thunbergiis, 48 parts of Radix Platycodoniss, 96 parts of Radix Puerariaes, 96 parts of Radix Trichosanthis, 96 parts of Semen Armeniacae Amarums, 0.61 part of Folium perillae acutae oil.
2. the Chinese medicine composition that a kind of dispeling wind and relieving fever antitussive according to claim 1 reduces phlegm, it is characterized in that described active component adopts following method to prepare: half summer grade cold water soak is to the saturating heart, add 16 parts of Rhizoma Zingiberiss, decoct with water secondary, filtering. Radix Glehniae decocts with water secondary, filter, merge above decocting liquid and be concentrated in right amount.Cortex Magnoliae Officinalis 60% ethanol percolate extraction.Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis 60% ethanol percolate extraction, collects first extract standby, continues to extract.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract standby, continues to extract, and merges above ethanol extract and continuous extract, reclaims ethanol and is concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.It is standby that Semen Armeniacae Amarum extracts aqua armeniacae.By above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, the alcoholic solution of aqua armeniacae, Folium perillae acutae oil merges, and mixes, and adds 0.25% ammonia, and adjustment capacity and containing alcohol amount stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merge.Continue standing seven days, obtain liquids A.
3. the Chinese medicine composition that a kind of dispeling wind and relieving fever antitussive according to claim 2 reduces phlegm, is characterized in that: half summer grade cold water soak, to the saturating heart, adds 16 parts of Rhizoma Zingiberiss, decoct with water secondary, add for the first time 10 times of water, decoct 2 hours, add for the second time 8 times of water, decoct 1 hour, filter; Radix Glehniae decocts with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, filters, and merges above decocting liquid and is concentrated into.8 times of amount 60% ethanol percolate extraction for Cortex Magnoliae Officinalis, 8 times of amount 60% ethanol percolate extraction for Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis, collect the liquid of just filtering standby, and continuation is extracted.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract standby, continues to extract.Merge above ethanol extract and the continuous liquid of filtering, reclaim ethanol and be concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.Semen Armeniacae Amarum deoils, and makes almond cookie, extracts aqua armeniacae standby.Just the filter alcoholic solution of liquid, aqua armeniacae, Folium perillae acutae oil of above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, medical material is merged, mix, add 0.25% ammonia, adjustment capacity and containing alcohol amount, stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merging add simple syrup to stir evenly.Continue standing seven days, obtain liquids A.
4. according to the Chinese medicine composition that in claims 1 to 3, a kind of dispeling wind and relieving fever antitussive described in any one reduces phlegm, it is characterized in that: affiliated medicine also contains the acceptable adjuvant of pharmaceutics.
5. the Chinese medicine composition that a kind of dispeling wind and relieving fever antitussive according to claim 4 reduces phlegm, is characterized in that: the acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
6. the Chinese medicine composition that a kind of dispeling wind and relieving fever antitussive according to claim 4 reduces phlegm, is characterized in that: the dosage form of described Chinese medicine composition is peroral dosage form, comprises pill, tablet, capsule, syrup or oral liquid.
7. a preparation method for the Chinese medicine composition that dispeling wind and relieving fever antitussive reduces phlegm, is characterized in that: take 192 parts of the Rhizoma Pinelliaes, 96 parts of Radix Glehniaes, 48 parts of Cortex Magnoliae Officinalis, 192 parts of Exocarpium Citri Grandises, 192 parts of Radix Peucedanis, 96 parts of Radix Scutellariaes, 96 parts of Bulbus Fritillariae Thunbergiis, 48 parts of Radix Platycodoniss, 96 parts of Radix Puerariaes, 96 parts of Radix Trichosanthis, 96 parts of Semen Armeniacae Amarums, 0.61 part of Folium perillae acutae oil.Half summer grade cold water soak, to the saturating heart, adds 16 parts of Rhizoma Zingiberiss, decocts with water secondary, filters. and Radix Glehniae decocts with water secondary, filters, and merges above decocting liquid and is concentrated in right amount.Cortex Magnoliae Officinalis 60% ethanol percolate extraction.Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis 60% ethanol percolate extraction, collects first extract standby, continues to extract.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract standby, continues to extract, and merges above ethanol extract and continuous extract, reclaims ethanol and is concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.It is standby that Semen Armeniacae Amarum extracts aqua armeniacae.By above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, the alcoholic solution of aqua armeniacae, Folium perillae acutae oil merges, and mixes, and adds 0.25% ammonia, and adjustment capacity and containing alcohol amount stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merge.Continue standing seven days, obtain liquids A.
8. the Chinese medicine composition that a kind of dispeling wind and relieving fever antitussive according to claim 1 according to claim 7 reduces phlegm, is characterized in that: take 192 parts of the Rhizoma Pinelliaes, 96 parts of Radix Glehniaes, 48 parts of Cortex Magnoliae Officinalis, 192 parts of Exocarpium Citri Grandises, 192 parts of Radix Peucedanis, 96 parts of Radix Scutellariaes, 96 parts of Bulbus Fritillariae Thunbergiis, 48 parts of Radix Platycodoniss, 96 parts of Radix Puerariaes, 96 parts of Radix Trichosanthis, 96 parts of Semen Armeniacae Amarums, 0.61 part of Folium perillae acutae oil.Half summer grade cold water soak, to the saturating heart, adds 16 parts of Rhizoma Zingiberiss, decocts with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, filters; Radix Glehniae decocts with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, filters, and merges above decocting liquid and is concentrated into.8 times of amount 60% ethanol percolate extraction for Cortex Magnoliae Officinalis, 8 times of amount 60% ethanol percolate extraction for Exocarpium Citri Grandis, Radix Peucedani, Radix Scutellariae, Bulbus Fritillariae Thunbergii, Radix Platycodonis, collect the liquid of just filtering standby, and continuation is extracted.Radix Puerariae, Radix Trichosanthis 25% ethanol extraction, collects first extract standby, continues to extract.Merge above ethanol extract and the continuous liquid of filtering, reclaim ethanol and be concentrated in right amount.Folium perillae acutae oil dissolves with appropriate amount of ethanol.Semen Armeniacae Amarum deoils, and makes almond cookie, extracts aqua armeniacae standby.Just the filter alcoholic solution of liquid, aqua armeniacae, Folium perillae acutae oil of above water drug-decocting concentrating liquid, ethanol extraction concentrated solution, medical material is merged, mix, add 0.25% ammonia, adjustment capacity and containing alcohol amount, stirs evenly.Regulate pH value 7～8, standing three days, draw supernatant, remaining liquid filtering precipitation and supernatant merging add simple syrup to stir evenly.Continue standing seven days, obtain liquids A.
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| CN201210360680.9A Pending CN103656137A (en) | 2012-09-26 | 2012-09-26 | Traditional Chinese medicine composition for dispelling wind, relieving heat, stopping cough and resolving phlegm and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412858A (en) * | 2015-11-19 | 2016-03-23 | 岳海棠 | Syrup and preparation method thereof |
| CN107412551A (en) * | 2017-06-30 | 2017-12-01 | 禹州市天源生物科技有限公司 | A kind of Chinese traditional medicine composition side of removing heat from the lung to relieve cough and preparation method thereof |
-
2012
- 2012-09-26 CN CN201210360680.9A patent/CN103656137A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105412858A (en) * | 2015-11-19 | 2016-03-23 | 岳海棠 | Syrup and preparation method thereof |
| CN107412551A (en) * | 2017-06-30 | 2017-12-01 | 禹州市天源生物科技有限公司 | A kind of Chinese traditional medicine composition side of removing heat from the lung to relieve cough and preparation method thereof |
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Application publication date: 20140326 |