CN109528857A - A kind of campanulaceae particle and preparation method thereof for treating respiratory disease caused by haze - Google Patents
A kind of campanulaceae particle and preparation method thereof for treating respiratory disease caused by haze Download PDFInfo
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Abstract
A kind of campanulaceae particle and preparation method thereof for treating respiratory disease caused by haze, it belongs to medical health field.The technical problem to be solved in the present invention is respiratory disease caused by treatment haze.A kind of campanulaceae particle for treating respiratory disease caused by haze of the present invention is mainly by platycodon root polysaccharide medicinal extract, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry-leaf extract, Astragalus Root P.E, houttuynia extract, snow pear extract, Aspartame, sucrose, dextrin, ethyl alcohol are made, after mixing, ethyl alcohol is added, softwood is made, cross 10 meshes, dry under the conditions of 80 DEG C, the campanulaceae particle of the respiratory disease caused by No. 4 sieves are made for treating haze is made after particle.The present invention uses medicinal and edible plant to be made granule for raw material, formula rationally, have no toxic side effect, have the function of that clearing lung-heat, Eradicates cough are anti-inflammatory, solve the problems, such as traditional campanulaceae Traditional Chinese medicine decocting, take it is inconvenient.
Description
Technical field
The invention belongs to medical health fields；More particularly to a kind of for treating the tangerine of respiratory disease caused by haze
Obstruct particle and preparation method thereof.
Background technique
In recent years, being seriously affected with the increasingly exacerbation of haze weather to people's health generation.PM2.5Refer to air
Middle diameter is not more than 2.5 microns of particulate matter, these particulate matters are due to that directly can suck lung by human body, to exhale human body
Desorption system causes to seriously threaten, and is in PM for a long time2.5In the case where excessively high, the morbidity risk rate of lung cancer can be improved.
Campanulaceae is the dry root of Campanulaceae campanulaceae, is the traditional Chinese medicine of integration of drinking and medicinal herbs.Its toil mild-natured, sweet in flavor；Return
Lung, stomach meridian；With promoting the dispersing function of the lung, relieving sore-throat, eliminating the phlegm, apocenosis and other effects.Campanulaceae contains various active constituents, such as saponin(e, polysaccharide, volatile oil
Isoreactivity ingredient, these active constituents have extensive biological action, and antitumor, immunological regulation, eliminating phlegm and relieving cough are relievingd asthma,
Due to it is reported that platycodon root polysaccharide usually not cytotoxicity, does not influence cell normal function, so that the research of platycodon root polysaccharide is gradually
As hot spot.
Summary of the invention
It is an object of the present invention to provide a kind of campanulaceaes for being used to treat respiratory disease caused by haze significant in efficacy
Particle and preparation method thereof.
The invention is realized by the following technical scheme:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze, described one kind is drawn for treating haze
The campanulaceae particle of the respiratory disease risen is mainly by platycodon root polysaccharide medicinal extract, black fungus extract, Honegsukle flower P.E, the root of Dahurain angelica
Extract, mulberry-leaf extract, Astragalus Root P.E, houttuynia extract, snow pear extract, Aspartame, sucrose, dextrin, ethyl alcohol
It is made, parts by weight are respectively 17~25 parts of platycodon root polysaccharide medicinal extract, 1~3 part of black fungus extract, 4~8 parts of gold and silver
Flower extract, 3~7 parts of Angelica Dahurica extract, 0.5~3 part of mulberry-leaf extract, 1~5 part of Astragalus Root P.E, 0.5~2 part
Houttuynia extract, 5~20 parts of snow pear extract, 10~20 parts of Aspartame, 3~40 parts of sucrose, 5~15 parts
Dextrin, 2~10 parts of ethyl alcohol.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, a kind of use
The parts by weight of platycodon root polysaccharide medicinal extract are 20~25 parts, black wood in the campanulaceae particle for treating respiratory disease caused by haze
The parts by weight that the parts by weight of ear extract are 1~3 part, the parts by weight of Honegsukle flower P.E are 5~7 parts, Angelica Dahurica extract
Number is 4~6 parts, the parts by weight of mulberry-leaf extract are 1~2 part, the parts by weight of Astragalus Root P.E are 2~3 parts, cordate houttuynia mentions
The parts by weight for taking object are 0.5~2 part, the parts by weight of snow pear extract are 10~15 parts, the parts by weight of Aspartame are
12~15 parts, the parts by weight of sucrose be 10~20 parts, the parts by weight of dextrin are 10~12 parts, the parts by weight of ethyl alcohol are 3
~7 parts.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, a kind of use
The parts by weight of platycodon root polysaccharide medicinal extract are 22 parts in the campanulaceae particle for treating respiratory disease caused by haze, black fungus mentions
The parts by weight for taking object are 2 parts, the parts by weight of Honegsukle flower P.E are 3 parts, the parts by weight of Angelica Dahurica extract are 5 parts, mulberry
The parts by weight of leaf extract are 1 part, the parts by weight of Astragalus Root P.E are 3 parts, the parts by weight of houttuynia extract are 1
Part, the parts by weight of snow pear extract be 12 parts, the parts by weight of Aspartame are 14 parts, the parts by weight of sucrose are 15 parts,
The parts by weight of dextrin are 11 parts, the parts by weight of ethyl alcohol are 5 parts.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, a kind of use
The parts by weight of platycodon root polysaccharide medicinal extract are 25 parts in the campanulaceae particle for treating respiratory disease caused by haze, black fungus mentions
The parts by weight for taking object are 3 parts, the parts by weight of Honegsukle flower P.E are 5 parts, the parts by weight of Angelica Dahurica extract are 6 parts, mulberry
The parts by weight of leaf extract are 1 part, the parts by weight of Astragalus Root P.E are 5 parts, the parts by weight of houttuynia extract are 2
Part, the parts by weight of snow pear extract be 13 parts, the parts by weight of Aspartame are 12 parts, the parts by weight of sucrose are 20 parts,
The parts by weight of dextrin are 14 parts, the parts by weight of ethyl alcohol are 7 parts.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, black fungus extract
In be rich in Auricularia polysaccharide abundant, by L-fucose, L-arabinose, D- xylose, D-MANNOSE, D-Glucose and grape alditol
The monosaccharide such as acid composition, can be dissolved in water, there is the physiological activity of enhancing body's immunity.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, Honegsukle flower P.E
It being capable of antibacterial and antiviral.I.e. to staphylococcus aureus, hemolytic streptococcus, dysentery, typhoid fever, diplococcus meningitidis, pneumonia
Diplococcus, green pus and influenza virus etc. have obvious inhibiting effect；The function of having enhancing immune, honeysuckle can promote lymph thin
Dysuria with lower abdominal colic enhances the phagocytic function of leucocyte；Can be anti-inflammatory, antipyretic, honeysuckle can promote the release of cortex hormone of aadrenaline, right
Inflammation has obvious inhibiting effect.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, Angelica Dahurica extract master
To contain Coumarins and volatile oil component, there is anti-inflammatory, analgesia, inhibit a variety of pharmacological activity such as pathogenic microorganism, antitumor.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, in mulberry-leaf extract
Contain the several physiological active substances such as flavones in mulberry leaves, mulberry leaf polyphenol, mulberry leaf polysaccharide.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, Astragalus Root P.E tool
There is strengthen immunity, enhances energy, antifatigue effect.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, houttuynia extract
With clearing heat and detoxicating, the carbuncle that disappears apocenosis, the function of inducing diuresis for treating strangurtia.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, pyrus nivalis category rosaceae
Pyrus L, contained full of nutrition, rich in carbohydrate, malic acid and multivitamin etc., pyrus nivalis can not only promote appetite, help to disappear
Change, moreover it is possible to promote the production of body fluid to quench thirst, only phlegm disease, heat-clearing solution fire, moistening lung remove dryness.
It is of the present invention a kind of for treating the preparation method of the campanulaceae particle of respiratory disease caused by haze, it wraps
Include following steps:
Step 1 prepares platycodon root polysaccharide medicinal extract, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry leaf respectively
Extract, Astragalus Root P.E, houttuynia extract, snow pear extract, for use；
Step 2 weighs Aspartame, sucrose, dextrin, ethyl alcohol, the platycodon root polysaccharide leaching prepared respectively according to parts by weight
Cream, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry-leaf extract, Astragalus Root P.E, houttuynia extract, snow
Snow pear extract, Baical Skullcap root P.E, Honegsukle flower P.E, Angelica Dahurica extract, mulberry will be added in pears extracting solution in platycodon root polysaccharide medicinal extract
Ethyl alcohol system is added after mixing in leaf extract, houttuynia extract, black fungus extract and sucrose, Aspartame, dextrin
At softwood, 10 meshes are crossed, drying under the conditions of 80 DEG C is made after particle, is sieved after No. 4, obtain described one kind for treating mist
The campanulaceae particle of respiratory disease caused by haze.
It is of the present invention a kind of for treating the preparation method of the campanulaceae particle of respiratory disease caused by haze, it walks
The preparation method of platycodon root polysaccharide medicinal extract is campanulaceae peeling in rapid 1, is cleaned, and air-dries and is placed within 2 days 50 DEG C of drying in baking oven, after drying
It is placed in pulverizer and crushes, cross 40~60 meshes, obtain campanulaceae dry powder；Dry balloonflower powder is put into round-bottomed flask, solid-liquid ratio
1:5~45g/ml addition ethyl alcohol, 1~3h of extraction time, 70~100 DEG C of Extracting temperature, extraction time 1~5 time, merging filtrate,
Platycodon root polysaccharide medicinal extract is obtained after reduced pressure.
It is of the present invention a kind of for treating the preparation method of the campanulaceae particle of respiratory disease caused by haze, it walks
The preparation method of black fungus extract is to take black fungus in rapid 1, is crushed, and is extracted with the ethyl alcohol that volume fraction is 50~80%, material
Liquor ratio is 1:30~50g/ml, extraction time 2~3 times, extracting solution is mixed, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethyl alcohol
Solution obtains black fungus extract；The preparation method of Honegsukle flower P.E is extracting honeysuckle in step 1, crushes, uses volume fraction
It being extracted for 50~80% ethyl alcohol, solid-liquid ratio is 1:15~35g/ml, extraction time 2~3 times, extracting solution mixed, 30~
It is concentrated under reduced pressure at 45 DEG C, eliminates ethanol solution, obtain Honegsukle flower P.E.
It is of the present invention a kind of for treating the preparation method of the campanulaceae particle of respiratory disease caused by haze, it walks
The preparation method of Angelica Dahurica extract is to take the root of Dahurain angelica in rapid 1, is crushed, and is extracted with the ethyl alcohol that volume fraction is 70~90%, solid-liquid ratio
For 1:10~30g/ml, extraction time 2~3 times, extracting solution is mixed, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethanol solution,
Obtain Angelica Dahurica extract；The preparation method of mulberry-leaf extract is to take mulberry leaf in step 1, is crushed, and is 50~90% with volume fraction
Ethyl alcohol extract, solid-liquid ratio be 1:25~35g/ml, extraction time 2~3 times, extracting solution is mixed, is depressurized at 30~45 DEG C
Concentration, eliminates ethanol solution, obtains mulberry-leaf extract.
It is of the present invention a kind of for treating the preparation method of the campanulaceae particle of respiratory disease caused by haze, it walks
The preparation method of Baical Skullcap root P.E is to take radix scutellariae in rapid 1, is crushed, and is extracted with the ethyl alcohol that volume fraction is 65~80%, solid-liquid ratio
For 1:30~35g/ml, extraction time 2~3 times, extracting solution is mixed, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethanol solution,
Obtain Baical Skullcap root P.E；In step 1 preparation method of houttuynia extract be take cordate houttuynia, crush, with volume fraction be 50~
75% ethyl alcohol extracts, and solid-liquid ratio is 1:10~50g/ml, extraction time 2~3 times, extracting solution is mixed, at 30~45 DEG C
It is concentrated under reduced pressure, eliminates ethanol solution, obtain houttuynia extract.
It is of the present invention a kind of for treating the preparation method of the campanulaceae particle of respiratory disease caused by haze, it walks
In rapid 1 the preparation method of snow pear extract be pyrus nivalis removed the peel, except core after be put into extractor, hot-water soak, under slight boiling condition
Hot water extracts 1~4 time, and solid-liquid ratio 1:5~20g/ml, 1~2h of extraction time, merging filtrate obtains snow pear extract after filtering.
The invention has the benefit that
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, using integration of drinking and medicinal herbs
Plant is that granule is made in raw material, and formula is reasonable, has no toxic side effect, and has the function of that clearing lung-heat, Eradicates cough are anti-inflammatory, being capable of Curing circumstance
Respiratory disease caused by problem, at the same solve the problems, such as traditional campanulaceae Traditional Chinese medicine decocting, take it is inconvenient.
It is of the present invention a kind of for treating the campanulaceae particle of respiratory disease caused by haze, it can directly swallow
It can also pour in water and drink into not only absorbing fast, significant in efficacy compared to traditional campanulaceae decoction.
Specific embodiment
Specific embodiment 1:
It is a kind of for treating the preparation method of the campanulaceae particle of respiratory disease caused by haze, include the following steps:
Step 1 prepares platycodon root polysaccharide medicinal extract, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry leaf respectively
Extract, Astragalus Root P.E, houttuynia extract, snow pear extract, for use；
Step 2 weighs Aspartame, sucrose, dextrin, ethyl alcohol, the platycodon root polysaccharide leaching prepared respectively according to parts by weight
Cream, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry-leaf extract, Astragalus Root P.E, houttuynia extract, snow
Pears extracting solution, the parts by weight of the platycodon root polysaccharide medicinal extract are 25 parts, the parts by weight of the black fungus extract are 3
Part, the parts by weight of the Honegsukle flower P.E be 5 parts, the parts by weight of the Angelica Dahurica extract are 6 parts, the mulberry
The parts by weight of leaf extract are 1 part, the parts by weight of the Astragalus Root P.E are 5 parts, the houttuynia extract
Parts by weight are 2 parts, the parts by weight of the snow pear extract are 13 parts, the parts by weight of the Aspartame are 12
Part, the parts by weight of the sucrose be 20 parts, the parts by weight that the parts by weight of the dextrin are 14 parts, the ethyl alcohol
It is 7 parts, snow pear extract, Baical Skullcap root P.E, Honegsukle flower P.E, Angelica Dahurica extract, mulberry leaf will be added in platycodon root polysaccharide medicinal extract
Extract, houttuynia extract, black fungus extract and sucrose, Aspartame, dextrin are added ethyl alcohol and are made after mixing
Softwood crosses 10 meshes, and drying under the conditions of 80 DEG C is made after particle, sieves after No. 4, obtains described one kind for treating haze
The campanulaceae particle of caused respiratory disease.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, the preparation method of platycodon root polysaccharide medicinal extract is campanulaceae peeling in step 1, is cleaned, and air-dries and is placed within 2 days 50 DEG C of drying in baking oven,
Drying, which is placed in pulverizer, to crush, and crosses 40~60 meshes, obtains campanulaceae dry powder；Dry balloonflower powder is put into round-bottomed flask,
Ethyl alcohol is added in solid-liquid ratio 1:5~45g/ml, and 1~3h of extraction time, extraction time 1~5 time, merges by 70~100 DEG C of Extracting temperature
Filtrate obtains platycodon root polysaccharide medicinal extract after reduced pressure.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, the preparation method of black fungus extract is to take black fungus in step 1, is crushed, and is mentioned with the ethyl alcohol that volume fraction is 50~80%
It takes, solid-liquid ratio is 1:30~50g/ml, extraction time 2~3 times, extracting solution is mixed, is concentrated under reduced pressure, eliminates at 30~45 DEG C
Ethanol solution obtains black fungus extract；The preparation method of Honegsukle flower P.E is extracting honeysuckle in step 1, crushes, uses volume
The ethyl alcohol that score is 50~80% extracts, and solid-liquid ratio is 1:15~35g/ml, extraction time 2~3 times, extracting solution is mixed,
It is concentrated under reduced pressure at 30~45 DEG C, eliminates ethanol solution, obtain Honegsukle flower P.E.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, the preparation method of Angelica Dahurica extract is to take the root of Dahurain angelica in step 1, is crushed, and is extracted with the ethyl alcohol that volume fraction is 70~90%, material
Liquor ratio is 1:10~30g/ml, extraction time 2~3 times, extracting solution is mixed, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethyl alcohol
Solution obtains Angelica Dahurica extract；In step 1 preparation method of mulberry-leaf extract be take mulberry leaf, crush, with volume fraction be 50~
90% ethyl alcohol extracts, and solid-liquid ratio is 1:25~35g/ml, extraction time 2~3 times, extracting solution is mixed, at 30~45 DEG C
It is concentrated under reduced pressure, eliminates ethanol solution, obtain mulberry-leaf extract.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, the preparation method of Baical Skullcap root P.E is to take radix scutellariae in step 1, is crushed, and is extracted with the ethyl alcohol that volume fraction is 65~80%, material
Liquor ratio is 1:30~35g/ml, extraction time 2~3 times, extracting solution is mixed, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethyl alcohol
Solution obtains Baical Skullcap root P.E；The preparation method of houttuynia extract is to take cordate houttuynia in step 1, crushes, is with volume fraction
50~75% ethyl alcohol extracts, and solid-liquid ratio is 1:10~50g/ml, extraction time 2~3 times, extracting solution is mixed, 30~45
It is concentrated under reduced pressure at DEG C, eliminates ethanol solution, obtain houttuynia extract.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, in step 1 preparation method of snow pear extract be pyrus nivalis removed the peel, except core after be put into extractor, hot-water soak, slightly boiled shape
Hot water extracts 1~4 time, solid-liquid ratio 1:5~20g/ml, 1~2h of extraction time under state, and merging filtrate obtains pyrus nivalis extraction after filtering
Liquid.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
A kind of campanulaceae particle for treating respiratory disease caused by haze of method preparation carries out animal testing: choosing elder brother
Bright kind of rat (40) is divided into 5 groups, every group 8,25 ± 2g of weight, simulates haze environment, Normal group using combustion method
Normal air is contacted, carries out physiological saline stomach-filling respectively with model control group, administration group is divided into high, medium and low three dosage components
It is not 0.5g/kg, 1g/kg, 3kg., it is primary to be given once daily campanulaceae particle solution, after continuous gavage 4 weeks, carries out animal testing, leads to
It crosses ELISA method and measures tumor necrosis factor TNF-alpha in mice serum, interleukins IL-6, detected by microplate reader, read it
OD value at 450nm draws standard curve by reference substance, compares OD value in unknown sample, obtain tumor necrosis factor in sample
The level value of sub- TNF-α, interleukins IL-6, the level value for measuring the TNF-α of rat is as shown in table 1, the level value of IL-6
It is as shown in table 2:
The level value contrast table of 1 TNF-α of table
Note: compared with model control group,*P < 0.05, compared with blank control group,△P>0.05
The level value contrast table of 2 IL-6 of table
Note: compared with model control group,*P < 0.05, compared with blank control group,△P>0.05
It can be seen that described is a kind of for treating the campanulaceae particle of respiratory disease caused by haze from table 1, table 2
The TNF-a and IL-6 level in mouse lung tissue can be reduced, described one kind is for treating respiratory disease caused by haze
High, normal, basic three dosage groups of campanulaceae particle rat TNF-a level it is statistically significant compared with model group (P < 0.05), with
Blank control group compares not statistically significant (P > 0.05).Described is a kind of for treating respiratory disease caused by haze
The rat IL-6 level of high, normal, basic three dosage groups of campanulaceae particle is statistically significant compared with model group (P < 0.05), with sky
White control group compares not statistically significant (P > 0.05).
Specific embodiment 2:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze, described one kind is drawn for treating haze
The campanulaceae particle of the respiratory disease risen is mainly by platycodon root polysaccharide medicinal extract, black fungus extract, Honegsukle flower P.E, the root of Dahurain angelica
Extract, mulberry-leaf extract, Astragalus Root P.E, houttuynia extract, snow pear extract, Aspartame, sucrose, dextrin, ethyl alcohol
It is made, parts by weight are respectively 17~25 parts of platycodon root polysaccharide medicinal extract, 1~3 part of black fungus extract, 4~8 parts of gold and silver
Flower extract, 3~7 parts of Angelica Dahurica extract, 0.5~3 part of mulberry-leaf extract, 1~5 part of Astragalus Root P.E, 0.5~2 part
Houttuynia extract, 5~20 parts of snow pear extract, 10~20 parts of Aspartame, 3~40 parts of sucrose, 5~15 parts
Dextrin, 2~10 parts of ethyl alcohol.
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze described in present embodiment, it is eaten using medicine
Homologous plant is that granule is made in raw material, and formula is reasonable, has no toxic side effect, and has the function of that clearing lung-heat, Eradicates cough are anti-inflammatory, can treat
Respiratory disease caused by environmental problem, at the same solve the problems, such as traditional campanulaceae Traditional Chinese medicine decocting, take it is inconvenient.
Specific embodiment 3:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze according to specific embodiment two,
The parts by weight of platycodon root polysaccharide medicinal extract are in a kind of campanulaceae particle for treating respiratory disease caused by haze
20~25 parts, the parts by weight of black fungus extract be 1~3 part, the parts by weight of Honegsukle flower P.E are 5~7 parts, the root of Dahurain angelica mentions
The parts by weight for taking object are 4~6 parts, the parts by weight of mulberry-leaf extract are 1~2 part, the parts by weight of Astragalus Root P.E be 2~
3 parts, the parts by weight of houttuynia extract be 0.5~2 part, the parts by weight of snow pear extract are 10~15 parts, Aspartame
Parts by weight be 12~15 parts, the parts by weight of sucrose are 10~20 parts, the parts by weight of dextrin are 10~12 parts, ethyl alcohol
Parts by weight are 3~7 parts.
Specific embodiment 4:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze according to specific embodiment two,
The parts by weight of platycodon root polysaccharide medicinal extract are in a kind of campanulaceae particle for treating respiratory disease caused by haze
22 parts, the parts by weight of black fungus extract be 2 parts, the weight that the parts by weight of Honegsukle flower P.E are 3 parts, Angelica Dahurica extract
Number is 5 parts, the parts by weight of mulberry-leaf extract are 1 part, the parts by weight of Astragalus Root P.E are 3 parts, houttuynia extract
The weight that parts by weight are 1 part, the parts by weight of snow pear extract are 12 parts, the parts by weight of Aspartame are 14 parts, sucrose
Number is 15 parts, the parts by weight of dextrin are 11 parts, the parts by weight of ethyl alcohol are 5 parts.
Specific embodiment 5:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze according to specific embodiment two,
The parts by weight of platycodon root polysaccharide medicinal extract are in a kind of campanulaceae particle for treating respiratory disease caused by haze
25 parts, the parts by weight of black fungus extract be 3 parts, the weight that the parts by weight of Honegsukle flower P.E are 5 parts, Angelica Dahurica extract
Number is 6 parts, the parts by weight of mulberry-leaf extract are 1 part, the parts by weight of Astragalus Root P.E are 5 parts, houttuynia extract
The weight that parts by weight are 2 parts, the parts by weight of snow pear extract are 13 parts, the parts by weight of Aspartame are 12 parts, sucrose
Number is 20 parts, the parts by weight of dextrin are 14 parts, the parts by weight of ethyl alcohol are 7 parts.
Specific embodiment 6:
It is a kind of for treating respiratory disease caused by haze according to one of specific embodiment two to five
The preparation method of campanulaceae particle, includes the following steps:
Step 1 prepares platycodon root polysaccharide medicinal extract, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry leaf respectively
Extract, Astragalus Root P.E, houttuynia extract, snow pear extract, for use；
Step 2 weighs Aspartame, sucrose, dextrin, ethyl alcohol, the platycodon root polysaccharide leaching prepared respectively according to parts by weight
Cream, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry-leaf extract, Astragalus Root P.E, houttuynia extract, snow
Snow pear extract, Baical Skullcap root P.E, Honegsukle flower P.E, Angelica Dahurica extract, mulberry will be added in pears extracting solution in platycodon root polysaccharide medicinal extract
Ethyl alcohol system is added after mixing in leaf extract, houttuynia extract, black fungus extract and sucrose, Aspartame, dextrin
At softwood, 10 meshes are crossed, drying under the conditions of 80 DEG C is made after particle, is sieved after No. 4, obtain described one kind for treating mist
The campanulaceae particle of respiratory disease caused by haze.
Specific embodiment 7:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze according to specific embodiment six
Preparation method, the preparation method of platycodon root polysaccharide medicinal extract is campanulaceae peeling in step 1, is cleaned, and air-dries 2 days and is placed on 50 in baking oven
DEG C drying, drying are placed in pulverizer and crush, cross 40~60 meshes, obtain campanulaceae dry powder；Dry balloonflower powder is put into round bottom
In flask, solid-liquid ratio 1:5~45g/ml addition ethyl alcohol, 1~3h of extraction time, 70~100 DEG C of Extracting temperature, extraction time 1~5
Secondary, merging filtrate obtains platycodon root polysaccharide medicinal extract after reduced pressure.
Specific embodiment 8:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze according to specific embodiment six
Preparation method, the preparation method of black fungus extract is to take black fungus in step 1, crushes, is 50~80% with volume fraction
Ethyl alcohol extract, solid-liquid ratio be 1:30~50g/ml, extraction time 2~3 times, extracting solution is mixed, is depressurized at 30~45 DEG C
Concentration, eliminates ethanol solution, obtains black fungus extract；The preparation method of Honegsukle flower P.E is extracting honeysuckle, powder in step 1
It is broken, it is extracted with the ethyl alcohol that volume fraction is 50~80%, solid-liquid ratio is 1:15~35g/ml, extraction time 2~3 times, will be extracted
Liquid mixing, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethanol solution, obtain Honegsukle flower P.E.
Specific embodiment 9:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze according to specific embodiment six
Preparation method, the preparation method of Angelica Dahurica extract is to take the root of Dahurain angelica in step 1, is crushed, the second for being 70~90% with volume fraction
Alcohol extracting, solid-liquid ratio are 1:10~30g/ml, extraction time 2~3 times, extracting solution are mixed, are concentrated under reduced pressure at 30~45 DEG C,
Ethanol solution is eliminated, Angelica Dahurica extract is obtained；The preparation method of mulberry-leaf extract is to take mulberry leaf in step 1, is crushed, with volume point
Number extracts for 50~90% ethyl alcohol, and solid-liquid ratio is 1:25~35g/ml, extraction time 2~3 times, extracting solution is mixed, 30
It is concentrated under reduced pressure at~45 DEG C, eliminates ethanol solution, obtain mulberry-leaf extract.
Specific embodiment 10:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze according to specific embodiment six
Preparation method, the preparation method of Baical Skullcap root P.E is to take radix scutellariae in step 1, is crushed, the second for being 65~80% with volume fraction
Alcohol extracting, solid-liquid ratio are 1:30~35g/ml, extraction time 2~3 times, extracting solution are mixed, are concentrated under reduced pressure at 30~45 DEG C,
Ethanol solution is eliminated, Baical Skullcap root P.E is obtained；The preparation method of houttuynia extract is to take cordate houttuynia in step 1, crushes, uses body
The ethyl alcohol that fraction is 50~75% extracts, and solid-liquid ratio is 1:10~50g/ml, extraction time 2~3 times, extracting solution is mixed,
It is concentrated under reduced pressure at 30~45 DEG C, eliminates ethanol solution, obtain houttuynia extract.
Specific embodiment 11:
It is a kind of for treating the campanulaceae particle of respiratory disease caused by haze according to specific embodiment six
Preparation method, in step 1 preparation method of snow pear extract be pyrus nivalis removed the peel, except core after be put into extractor, hot water leaching
It steeps, hot water extracts 1~4 time under slight boiling condition, and solid-liquid ratio 1:5~20g/ml, 1~2h of extraction time, merging filtrate obtains after filtering
To snow pear extract.
Specific embodiment 12:
It is a kind of for treating the preparation method of the campanulaceae particle of respiratory disease caused by haze, include the following steps:
Step 1 prepares platycodon root polysaccharide medicinal extract, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry leaf respectively
Extract, Astragalus Root P.E, houttuynia extract, snow pear extract, for use；
Step 2 weighs Aspartame, sucrose, dextrin, ethyl alcohol, the platycodon root polysaccharide leaching prepared respectively according to parts by weight
Cream, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry-leaf extract, Astragalus Root P.E, houttuynia extract, snow
Pears extracting solution, the parts by weight of the platycodon root polysaccharide medicinal extract are the parts by weight of 17~25 parts, the black fungus extract
Parts by weight for 1~3 part, the Honegsukle flower P.E are 4~8 parts, the parts by weight of the Angelica Dahurica extract be 3~
7 parts, the parts by weight of the mulberry-leaf extract be 0.5~3 part, the parts by weight of the Astragalus Root P.E are 1~5 part,
The parts by weight of the houttuynia extract are 0.5~2 part, the parts by weight of the snow pear extract are 5~20 parts, institute
The weight that the parts by weight for the Aspartame stated are 10~20 parts, the parts by weight of the sucrose are 3~40 parts, the dextrin
Measure number be 5~15 parts, the parts by weight of the ethyl alcohol are 2~10 parts, will in platycodon root polysaccharide medicinal extract be added snow pear extract,
Baical Skullcap root P.E, Honegsukle flower P.E, Angelica Dahurica extract, mulberry-leaf extract, houttuynia extract, black fungus extract and sugarcane
Sugar, Aspartame, dextrin are added ethyl alcohol and softwood are made, cross 10 meshes, be made after particle under the conditions of 80 DEG C after mixing
It is dry, it sieves, obtains described a kind of for treating the campanulaceae particle of respiratory disease caused by haze after No. 4.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, the preparation method of platycodon root polysaccharide medicinal extract is campanulaceae peeling in step 1, is cleaned, and air-dries and is placed within 2 days 50 DEG C of drying in baking oven,
Drying, which is placed in pulverizer, to crush, and crosses 40~60 meshes, obtains campanulaceae dry powder；Dry balloonflower powder is put into round-bottomed flask,
Ethyl alcohol is added in solid-liquid ratio 1:5~45g/ml, and 1~3h of extraction time, extraction time 1~5 time, merges by 70~100 DEG C of Extracting temperature
Filtrate obtains platycodon root polysaccharide medicinal extract after reduced pressure.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, the preparation method of black fungus extract is to take black fungus in step 1, is crushed, and is mentioned with the ethyl alcohol that volume fraction is 50~80%
It takes, solid-liquid ratio is 1:30~50g/ml, extraction time 2~3 times, extracting solution is mixed, is concentrated under reduced pressure, eliminates at 30~45 DEG C
Ethanol solution obtains black fungus extract；The preparation method of Honegsukle flower P.E is extracting honeysuckle in step 1, crushes, uses volume
The ethyl alcohol that score is 50~80% extracts, and solid-liquid ratio is 1:15~35g/ml, extraction time 2~3 times, extracting solution is mixed,
It is concentrated under reduced pressure at 30~45 DEG C, eliminates ethanol solution, obtain Honegsukle flower P.E.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, the preparation method of Angelica Dahurica extract is to take the root of Dahurain angelica in step 1, is crushed, and is extracted with the ethyl alcohol that volume fraction is 70~90%, material
Liquor ratio is 1:10~30g/ml, extraction time 2~3 times, extracting solution is mixed, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethyl alcohol
Solution obtains Angelica Dahurica extract；In step 1 preparation method of mulberry-leaf extract be take mulberry leaf, crush, with volume fraction be 50~
90% ethyl alcohol extracts, and solid-liquid ratio is 1:25~35g/ml, extraction time 2~3 times, extracting solution is mixed, at 30~45 DEG C
It is concentrated under reduced pressure, eliminates ethanol solution, obtain mulberry-leaf extract.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, the preparation method of Baical Skullcap root P.E is to take radix scutellariae in step 1, is crushed, and is extracted with the ethyl alcohol that volume fraction is 65~80%, material
Liquor ratio is 1:30~35g/ml, extraction time 2~3 times, extracting solution is mixed, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethyl alcohol
Solution obtains Baical Skullcap root P.E；The preparation method of houttuynia extract is to take cordate houttuynia in step 1, crushes, is with volume fraction
50~75% ethyl alcohol extracts, and solid-liquid ratio is 1:10~50g/ml, extraction time 2~3 times, extracting solution is mixed, 30~45
It is concentrated under reduced pressure at DEG C, eliminates ethanol solution, obtain houttuynia extract.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method, in step 1 preparation method of snow pear extract be pyrus nivalis removed the peel, except core after be put into extractor, hot-water soak, slightly boiled shape
Hot water extracts 1~4 time, solid-liquid ratio 1:5~20g/ml, 1~2h of extraction time under state, and merging filtrate obtains pyrus nivalis extraction after filtering
Liquid.
It is a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze described in present embodiment
Method is prepared a kind of for treating the campanulaceae particle of respiratory disease caused by haze, progress clinical effectiveness monitoring: selection
The bronchitis as caused by haze weather, pneumonia and the patient of exogenous cough totally 300, the patient of every kind of disease 100,
Middle male patient 50, female patient 50, the age between 20-70 years old, is divided into test group and control group, takes orally 3 times a day,
Each 15g, 7 days as a course for the treatment of by exogenous cough, and bronchitis, pneumonia two weeks are as a treatment course, and control group is taken treatment and exhaled
Certain Chinese medicine proved prescription of desorption system disease.
Curative effect judging standard is as follows:
It is effective: cough symptom recovery from illness, normal Working Life.
Improve: cough symptom mitigates, normal life.
Invalid: symptom influences normal life without improvement.
Exogenous cough's medication Contrast on effect table is as shown in table 1:
1 exogenous cough of table medication Contrast on effect table
Bronchitis medication Contrast on effect table is as shown in table 2:
2 bronchitis of table medication Contrast on effect table
Pneumonia medication Contrast on effect table is as shown in table 3:
3 pneumonia of table medication Contrast on effect table
It is from table, it can be seen that a kind of for treating the tangerine of respiratory disease caused by haze described in present embodiment
Stalk particle preparation method be prepared it is a kind of for treating the campanulaceae particle of respiratory disease caused by haze, to due to mist
Cough, bronchitis, pneumonia caused by haze weather have good curative effect.
Safety: patient does not have found obvious adverse reaction in drug administration process, duration of medication patient routine urinalysis, renal function,
Coagulation function is showed no obvious abnormalities.
Claims (10)
1. a kind of for treating the campanulaceae particle of respiratory disease caused by haze, it is characterised in that: described one kind is used for
The campanulaceae particle of respiratory disease caused by haze is treated mainly by platycodon root polysaccharide medicinal extract, black fungus extract, honeysuckle
Extract, Angelica Dahurica extract, mulberry-leaf extract, Astragalus Root P.E, houttuynia extract, snow pear extract, Aspartame, sugarcane
Sugar, dextrin, ethyl alcohol are made, parts by weight be respectively 17~25 parts of platycodon root polysaccharide medicinal extract, 1~3 part of black fungus extract,
4~8 parts of Honegsukle flower P.E, 3~7 parts of Angelica Dahurica extract, 0.5~3 part of mulberry-leaf extract, 1~5 part of astragalus extraction
Object, 0.5~2 part of houttuynia extract, 5~20 parts of snow pear extract, 10~20 parts of Aspartame, 3~40 parts of sugarcane
Sugar, 5~15 parts of dextrin, 2~10 parts of ethyl alcohol.
2. according to claim 1 a kind of for treating the campanulaceae particle of respiratory disease caused by haze, feature
It is: the parts by weight of platycodon root polysaccharide medicinal extract in a kind of campanulaceae particle for treating respiratory disease caused by haze
Number is 20~25 parts, the parts by weight of black fungus extract are 1~3 part, the parts by weight of Honegsukle flower P.E are 5~7 parts, white
The parts by weight that the parts by weight of root of Dahurian angelica extract are 4~6 parts, the parts by weight of mulberry-leaf extract are 1~2 part, Astragalus Root P.E
Parts by weight for 2~3 parts, houttuynia extract are 0.5~2 part, the parts by weight of snow pear extract are 10~15 parts, A Si
The parts by weight of Ba Tian are 12~15 parts, the parts by weight of sucrose are 10~20 parts, the parts by weight of dextrin are 10~12 parts, second
The parts by weight of alcohol are 3~7 parts.
3. it is according to claim 1 or 2 a kind of for treating the campanulaceae particle of respiratory disease caused by haze, it is special
Sign is: the weight of platycodon root polysaccharide medicinal extract in a kind of campanulaceae particle for treating respiratory disease caused by haze
Number is 22 parts, the parts by weight of black fungus extract are 2 parts, the parts by weight of Honegsukle flower P.E are 3 parts, Angelica Dahurica extract
Parts by weight be 5 parts, the parts by weight of mulberry-leaf extract are 1 part, the parts by weight of Astragalus Root P.E are 3 parts, cordate houttuynia mentions
The parts by weight for taking object are 1 part, the parts by weight of snow pear extract are 12 parts, the parts by weight of Aspartame are 14 parts, sucrose
Parts by weight be 15 parts, the parts by weight of dextrin are 11 parts, the parts by weight of ethyl alcohol are 5 parts.
4. a kind of for treating the campanulaceae particle of respiratory disease caused by haze according to claim, feature exists
In: the parts by weight of platycodon root polysaccharide medicinal extract in a kind of campanulaceae particle for treating respiratory disease caused by haze
The weight that parts by weight for 25 parts, black fungus extract are 3 parts, the parts by weight of Honegsukle flower P.E are 5 parts, Angelica Dahurica extract
Amount number is 6 parts, the parts by weight of mulberry-leaf extract are 1 part, the parts by weight of Astragalus Root P.E are 5 parts, houttuynia extract
Parts by weight be 2 parts, the weight that the parts by weight of snow pear extract are 13 parts, the parts by weight of Aspartame are 12 parts, sucrose
Amount number is 20 parts, the parts by weight of dextrin are 14 parts, the parts by weight of ethyl alcohol are 7 parts.
5. a kind of for treating the campanulaceae particle of respiratory disease caused by haze described in a kind of one of claim 1-4
Preparation method, characterized by the following steps:
Step 1 prepares platycodon root polysaccharide medicinal extract, black fungus extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry leaf extraction respectively
Object, Astragalus Root P.E, houttuynia extract, snow pear extract, for use；
Step 2 weighs Aspartame respectively according to parts by weight, is sucrose, dextrin, ethyl alcohol, the platycodon root polysaccharide medicinal extract prepared, black
Auricularia extract, Honegsukle flower P.E, Angelica Dahurica extract, mulberry-leaf extract, Astragalus Root P.E, houttuynia extract, pyrus nivalis mention
Liquid is taken, is mentioned snow pear extract, Baical Skullcap root P.E, Honegsukle flower P.E, Angelica Dahurica extract, mulberry leaf are added in platycodon root polysaccharide medicinal extract
Object, houttuynia extract, black fungus extract and sucrose, Aspartame, dextrin are taken, after mixing, addition ethyl alcohol is made soft
Material crosses 10 meshes, and drying under the conditions of 80 DEG C is made after particle, sieves after No. 4, obtains described one kind and draws for treating haze
The campanulaceae particle of the respiratory disease risen.
6. according to claim 5 a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze
Method, it is characterised in that: the preparation method of platycodon root polysaccharide medicinal extract is campanulaceae peeling in step 1, is cleaned, and air-dries 2 days and is placed on baking oven
In 50 DEG C of drying, drying is placed in pulverizer and crushes, cross 40~60 meshes, obtain campanulaceae dry powder；Dry balloonflower powder is put into
In round-bottomed flask, solid-liquid ratio 1:5~45g/ml addition ethyl alcohol, 1~3h of extraction time, 70~100 DEG C of Extracting temperature, extraction time
1~5 time, merging filtrate obtains platycodon root polysaccharide medicinal extract after reduced pressure.
7. according to claim 5 a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze
Method, it is characterised in that: in step 1 preparation method of black fungus extract be take black fungus, crush, with volume fraction be 50~
80% ethyl alcohol extracts, and solid-liquid ratio is 1:30~50g/ml, extraction time 2~3 times, extracting solution is mixed, at 30~45 DEG C
It is concentrated under reduced pressure, eliminates ethanol solution, obtain black fungus extract；The preparation method of Honegsukle flower P.E is to take gold and silver in step 1
Flower crushes, and is extracted with the ethyl alcohol that volume fraction is 50~80%, and solid-liquid ratio is 1:15~35g/ml, extraction time 2~3 times, will
Extracting solution mixing, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethanol solution, obtain Honegsukle flower P.E.
8. according to claim 5 a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze
Method, it is characterised in that: the preparation method of Angelica Dahurica extract is to take the root of Dahurain angelica in step 1, is crushed, and is 70~90% with volume fraction
Ethyl alcohol extracts, and solid-liquid ratio is 1:10~30g/ml, extraction time 2~3 times, extracting solution is mixed, is depressurized at 30~45 DEG C dense
Contracting, eliminates ethanol solution, obtains Angelica Dahurica extract；The preparation method of mulberry-leaf extract is to take mulberry leaf in step 1, crushes, uses body
The ethyl alcohol that fraction is 50~90% extracts, and solid-liquid ratio is 1:25~35g/ml, extraction time 2~3 times, extracting solution is mixed,
It is concentrated under reduced pressure at 30~45 DEG C, eliminates ethanol solution, obtain mulberry-leaf extract.
9. according to claim 5 a kind of for treating the preparation side of the campanulaceae particle of respiratory disease caused by haze
Method, it is characterised in that: the preparation method of Baical Skullcap root P.E is to take radix scutellariae in step 1, is crushed, and is 65~80% with volume fraction
Ethyl alcohol extracts, and solid-liquid ratio is 1:30~35g/ml, extraction time 2~3 times, extracting solution is mixed, is depressurized at 30~45 DEG C dense
Contracting, eliminates ethanol solution, obtains Baical Skullcap root P.E；The preparation method of houttuynia extract is to take cordate houttuynia in step 1, is crushed,
It is extracted with the ethyl alcohol that volume fraction is 50~75%, solid-liquid ratio is 1:10~50g/ml, extraction time 2~3 times, extracting solution is mixed
It closes, is concentrated under reduced pressure at 30~45 DEG C, eliminates ethanol solution, obtain houttuynia extract.
10. according to claim 5 a kind of for treating the preparation of the campanulaceae particle of respiratory disease caused by haze
Method, it is characterised in that: in step 1 preparation method of snow pear extract be pyrus nivalis removed the peel, except core after be put into extractor, heat
Water impregnates, and hot water extracts 1~4 time, solid-liquid ratio 1:5~20g/ml, 1~2h of extraction time under slight boiling condition, and filter is merged after filtering
Liquid obtains snow pear extract.
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| CN105250920A (en) * | 2015-11-10 | 2016-01-20 | 北京市祖国红医疗科技中心（有限合伙） | Traditional Chinese medicine for treating respiratory diseases caused by haze and preparation method and application thereof |
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| CN105250920A (en) * | 2015-11-10 | 2016-01-20 | 北京市祖国红医疗科技中心（有限合伙） | Traditional Chinese medicine for treating respiratory diseases caused by haze and preparation method and application thereof |
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| 郑敏等: "防雾霾肺功能保健食品和中药饮片的研究进展", 《化学工程与装备》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113181263A (en) * | 2021-05-24 | 2021-07-30 | 陕西省人民医院 | Platycodon grandiflorum particles for treating respiratory system diseases caused by haze and preparation method thereof |
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