CN113181263A - Platycodon grandiflorum particles for treating respiratory system diseases caused by haze and preparation method thereof - Google Patents
Platycodon grandiflorum particles for treating respiratory system diseases caused by haze and preparation method thereof Download PDFInfo
- Publication number
- CN113181263A CN113181263A CN202110567539.5A CN202110567539A CN113181263A CN 113181263 A CN113181263 A CN 113181263A CN 202110567539 A CN202110567539 A CN 202110567539A CN 113181263 A CN113181263 A CN 113181263A
- Authority
- CN
- China
- Prior art keywords
- parts
- platycodon grandiflorum
- extract
- particles
- haze
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of medical care, in particular to platycodon grandiflorum particles for treating respiratory diseases caused by haze and a preparation method thereof. Wherein, the platycodon grandiflorum polysaccharide is 15-25 parts, the thyme leaf is 5-10 parts, the perilla seed extract is 4-8 parts, the mullein extract is 3-7 parts, the myrtle oil is 10-15 parts, the ardisia crenata is 2-6 parts, and the dark plum flesh is 1-3 parts. The platycodon grandiflorum particles have good curative effects on cough, bronchitis and pneumonia caused by haze weather, and the effective rates of the platycodon grandiflorum particles are respectively 97.3%, 98% and 92.5%.
Description
Technical Field
The invention relates to the field of medical care, in particular to platycodon grandiflorum particles for treating respiratory diseases caused by haze and a preparation method thereof.
Background
In recent years, with the increasing of haze weather, the health of people is seriously affected. From the component of haze, it mainly comprises nitrate, organic carbon, sulphate, building structure granule, soil dust and metal particle, and the haze granule structure is special, and the surface area is relatively big, so can carry and absorb some poisonous and harmful substance often. The toxic and harmful substances have strong deposition and penetrability, so that the toxic and harmful substances can penetrate through respiratory tracts and deposit in bronchioles and alveoli to form persistent stimulating factors of respiratory systems, and diseases such as tuberculosis, bronchitis, pneumonia, emphysema and even lung cancer are caused.
Radix Platycodi is the dried root of radix Platycodi of Campanulaceae, and is a traditional Chinese medicine with homology of medicine and food. It is neutral in nature and sweet, bitter and pungent in flavor; entering lung and stomach meridians; has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus. Platycodon grandiflorum contains various active ingredients such as saponin, polysaccharide, volatile oil and the like, the active ingredients have wide biological activity, and have the effects of resisting tumors, regulating immunity, eliminating phlegm, relieving cough and asthma and the like.
Disclosure of Invention
In order to solve the problems, the invention provides platycodon grandiflorum particles for treating respiratory diseases caused by haze and a preparation method thereof.
In order to achieve the purpose, the invention adopts the technical scheme that:
a radix Platycodi granule for treating respiratory system diseases caused by haze is prepared from radix Platycodi polysaccharide, folium Thymi, fructus Perillae extract, herba Calycoris Membranaceae extract, myrtle oil, radix Ardisiae Japonicae, and mume fructus meat.
Further, the material is mainly prepared from the following raw materials in parts by weight:
15-25 parts of platycodon grandiflorum polysaccharide, 5-10 parts of thyme leaf, 4-8 parts of perilla seed extract, 3-7 parts of verbena extract, 10-15 parts of myrtle oil, 2-6 parts of ardisia crenata and 1-3 parts of dark plum pulp.
Preferably, the material is mainly prepared from the following raw materials in parts by weight:
15-25 parts of platycodon grandiflorum polysaccharide, 5-10 parts of thyme leaf, 4-8 parts of perilla seed extract, 3-7 parts of verbena extract, 10-15 parts of myrtle oil, 2-6 parts of ardisia crenata and 1-3 parts of dark plum pulp.
Preferably, the material is mainly prepared from the following raw materials in parts by weight:
25 parts of platycodon grandiflorum polysaccharide, 10 parts of thyme leaf, 8 parts of perilla seed extract, 7 parts of mullein extract, 15 parts of myrtle oil, 6 parts of ardisia crenata and 3 parts of dark plum pulp.
Preferably, the material is mainly prepared from the following raw materials in parts by weight:
15 parts of platycodon grandiflorum polysaccharide, 5 parts of thyme leaf, 4 parts of perilla seed extract, 3 parts of mullein extract, 10 parts of myrtle oil, 2 parts of ardisia crenata and 1 part of dark plum pulp.
Preferably, the material is mainly prepared from the following raw materials in parts by weight:
20 parts of platycodon grandiflorum polysaccharide, 7.5 parts of thyme leaf, 6 parts of perilla seed extract, 5 parts of mullein extract, 12.5 parts of myrtle oil, 4 parts of ardisia crenata and 2 parts of dark plum pulp.
Further, the invention also provides a preparation method of the platycodon grandiflorum particles for treating the respiratory system diseases caused by haze, which comprises the following steps:
s1, respectively carrying out ultramicro grinding on the weighed thyme leaves, ardisia crenata and dark plum flesh to 200 meshes for later use;
s2, placing the obtained thyme leaf powder and the ardisia crenata sims powder into a high-pressure reaction kettle, adding a proper amount of purified water, performing subcritical water extraction treatment for 30-40 min at 100-150 ℃, performing centrifugal separation, and performing vacuum concentration on the obtained supernatant to obtain an extract;
s3, mixing the obtained extract with platycodon grandiflorum polysaccharide, perilla seed extract, mullein extract and myrtle mixed oil, uniformly stirring, and granulating to obtain particles with the particle size of 20-24 meshes;
s4, placing the smoked plum meat powder in a feed chamber of a coating granulator, placing the obtained particles in a rolling pot of a centrifugal granulator, starting a machine by using 3% hydroxypropyl methylcellulose as an adhesive, preparing drug-loaded pellets by adopting a powder lamination method, opening a discharge port when the drug-loaded pellets are 24-30 meshes, taking out the finished product, drying at 40 ℃, and screening by using a standard sieve to obtain the smoked plum drug-loaded pellets.
The platycodon grandiflorum particles have good curative effects on cough, bronchitis and pneumonia caused by haze weather, and the effective rates of the platycodon grandiflorum particles are respectively 97.3%, 98% and 92.5%.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.
Example 1
Platycodon grandiflorum particles for treating respiratory diseases caused by haze are prepared by the following method:
s1, weighing the following components in parts by weight: 25 parts of platycodon grandiflorum polysaccharide, 10 parts of thyme leaf, 8 parts of perilla seed extract, 7 parts of mullein extract, 15 parts of myrtle oil, 6 parts of ardisia crenata and 3 parts of dark plum pulp;
s2, respectively carrying out ultramicro grinding on the weighed thyme leaves, ardisia crenata and dark plum flesh to 200 meshes for later use;
s3, placing the obtained thyme leaf powder and the ardisia crenata sims powder into a high-pressure reaction kettle, adding a proper amount of purified water, performing subcritical water extraction treatment for 30-40 min at 100-150 ℃, performing centrifugal separation, and performing vacuum concentration on the obtained supernatant to obtain an extract;
s4, mixing the obtained extract with platycodon grandiflorum polysaccharide, perilla seed extract, mullein extract and myrtle mixed oil, uniformly stirring, and granulating to obtain particles with the particle size of 20-24 meshes;
s5, placing the smoked plum meat powder in a feed chamber of a coating granulator, placing the obtained particles in a rolling pot of a centrifugal granulator, starting a machine by using 3% hydroxypropyl methylcellulose as an adhesive, preparing drug-loaded pellets by adopting a powder lamination method, opening a discharge port when the drug-loaded pellets are 24-30 meshes, taking out the finished product, drying at 40 ℃, and screening by using a standard sieve to obtain the smoked plum drug-loaded pellets.
Example 2
Platycodon grandiflorum particles for treating respiratory diseases caused by haze are prepared by the following method:
s1, weighing the following components in parts by weight: 15 parts of platycodon grandiflorum polysaccharide, 5 parts of thyme leaf, 4 parts of perilla seed extract, 3 parts of mullein extract, 10 parts of myrtle oil, 2 parts of ardisia crenata and 1 part of dark plum pulp;
s2, respectively carrying out ultramicro grinding on the weighed thyme leaves, ardisia crenata and dark plum flesh to 200 meshes for later use;
s3, placing the obtained thyme leaf powder and the ardisia crenata sims powder into a high-pressure reaction kettle, adding a proper amount of purified water, performing subcritical water extraction treatment for 30-40 min at 100-150 ℃, performing centrifugal separation, and performing vacuum concentration on the obtained supernatant to obtain an extract;
s4, mixing the obtained extract with platycodon grandiflorum polysaccharide, perilla seed extract, mullein extract and myrtle mixed oil, uniformly stirring, and granulating to obtain particles with the particle size of 20-24 meshes;
s5, placing the smoked plum meat powder in a feed chamber of a coating granulator, placing the obtained particles in a rolling pot of a centrifugal granulator, starting a machine by using 3% hydroxypropyl methylcellulose as an adhesive, preparing drug-loaded pellets by adopting a powder lamination method, opening a discharge port when the drug-loaded pellets are 24-30 meshes, taking out the finished product, drying at 40 ℃, and screening by using a standard sieve to obtain the smoked plum drug-loaded pellets.
Example 3
Platycodon grandiflorum particles for treating respiratory diseases caused by haze are prepared by the following method:
s1, weighing the following components in parts by weight: 20 parts of platycodon grandiflorum polysaccharide, 7.5 parts of thyme leaf, 6 parts of perilla seed extract, 5 parts of mullein extract, 12.5 parts of myrtle oil, 4 parts of ardisia crenata and 2 parts of dark plum pulp;
s2, respectively carrying out ultramicro grinding on the weighed thyme leaves, ardisia crenata and dark plum flesh to 200 meshes for later use;
s3, placing the obtained thyme leaf powder and the ardisia crenata sims powder into a high-pressure reaction kettle, adding a proper amount of purified water, performing subcritical water extraction treatment for 30-40 min at 100-150 ℃, performing centrifugal separation, and performing vacuum concentration on the obtained supernatant to obtain an extract;
s4, mixing the obtained extract with platycodon grandiflorum polysaccharide, perilla seed extract, mullein extract and myrtle mixed oil, uniformly stirring, and granulating to obtain particles with the particle size of 20-24 meshes;
s5, placing the smoked plum meat powder in a feed chamber of a coating granulator, placing the obtained particles in a rolling pot of a centrifugal granulator, starting a machine by using 3% hydroxypropyl methylcellulose as an adhesive, preparing drug-loaded pellets by adopting a powder lamination method, opening a discharge port when the drug-loaded pellets are 24-30 meshes, taking out the finished product, drying at 40 ℃, and screening by using a standard sieve to obtain the smoked plum drug-loaded pellets.
The specific administration method comprises the following steps: the preparation is orally administered 3 times a day, 15g each time, 1 week for cough due to exogenous pathogenic factor as a treatment course, and 2 weeks for bronchitis and pneumonia as a treatment course.
Clinical data
Selecting 400 patients with bronchitis, pneumonia and exogenous cough caused by haze weather, wherein 100 patients with bronchitis, 80 patients with pneumonia, 220 patients with exogenous cough and half proportion of male and female, the age is 20-60 years old, and dividing the patients into a test group and a control group, wherein:
bronchitis control group: autumn pear lung moistening paste and dandelion anti-inflammatory oral liquid;
bronchial test group: platycodon grandiflorum granules obtained in example 1;
pneumonia control group: modified Beimu Guapian powder (for example, for patients with wind pathogen, cough due to throat itching and slight aversion to wind, lung-ventilating and pathogen-dispersing such as mulberry leaf, almond, cicada slough and great burdock achene can be added, for patients with severe dryness-heat, dry throat and obvious chong pain, and for patients with severe dryness-heat, dwarf lilyturf tuber, figwort root and gypsum can be added for clearing dryness and moistening lung, for patients with hoarseness and bloody sputum, orange red can be removed, and for patients with radix adenophorae, donkey-hide gelatin, bletilla striata and the like can be added for nourishing yin, clearing lung, reducing phlegm and stopping bleeding.) + oral liquid of cordate houttuynia for diminishing inflammation;
pneumonia test group: platycodon grandiflorum granules obtained in example 2;
control group with exogenous cough: a stropanthus decoction and dandelion anti-inflammatory oral liquid;
the experimental group for exogenous cough: platycodon grandiflorum granules obtained in example 3;
the test time is one treatment course.
The therapeutic effect criteria are as follows:
the effect is shown: cough symptoms are healed, and the work and life are basically normal.
Improvement: cough symptoms are relieved, and the life is basically normal.
And (4) invalidation: symptoms are not improved, and normal life is affected.
The comparison table of the effect of the bronchial medicine is shown in table 1:
TABLE 1
| Show effect | Improvement of life | Invalidation | |
| Bronchitis control group | 32 | 11 | 7 |
| Bronchitis test group | 45 | 4 | 1 |
The comparative table of the administration effect of pneumonia is shown in table 2:
TABLE 2
| Show effect | Improvement of life | Invalidation | |
| Pneumonia control group | 24 | 10 | 6 |
| Pneumonia test group | 30 | 7 | 3 |
The table for comparing the effect of the medicine for external cough is shown in table 3:
TABLE 3
| Show effect | Improvement of life | Invalidation | |
| Control group with exogenous cough | 90 | 10 | 10 |
| Test group for exogenous cough | 97 | 10 | 3 |
As can be seen from the table, the platycodon grandiflorum particles provided by the invention have good curative effects on cough, bronchitis and pneumonia caused by haze weather. And the patient does not have obvious adverse reaction in the process of taking the medicine, and the urinary routine, renal function and blood coagulation function of the patient are not obviously abnormal in the period of taking the medicine.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes or modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention. The embodiments and features of the embodiments of the present application may be combined with each other arbitrarily without conflict.
Claims (7)
1. A balloonflower granule for treating respiratory disease that haze arouses which characterized in that: mainly prepared from platycodon grandiflorum polysaccharide, thyme leaf, perilla seed extract, mullein extract, myrtle oil, ardisia crenata willd and dark plum pulp.
2. The platycodon grandiflorum particles for treating a respiratory disease caused by haze according to claim 1, wherein: the material is mainly prepared from the following raw materials in parts by weight:
15-25 parts of platycodon grandiflorum polysaccharide, 5-10 parts of thyme leaf, 4-8 parts of perilla seed extract, 3-7 parts of verbena extract, 10-15 parts of myrtle oil, 2-6 parts of ardisia crenata and 1-3 parts of dark plum pulp.
3. The platycodon grandiflorum particles for treating a respiratory disease caused by haze according to claim 1, wherein: the material is mainly prepared from the following raw materials in parts by weight:
15-25 parts of platycodon grandiflorum polysaccharide, 5-10 parts of thyme leaf, 4-8 parts of perilla seed extract, 3-7 parts of verbena extract, 10-15 parts of myrtle oil, 2-6 parts of ardisia crenata and 1-3 parts of dark plum pulp.
4. The platycodon grandiflorum particles for treating a respiratory disease caused by haze according to claim 1, wherein: the material is mainly prepared from the following raw materials in parts by weight:
25 parts of platycodon grandiflorum polysaccharide, 10 parts of thyme leaf, 8 parts of perilla seed extract, 7 parts of mullein extract, 15 parts of myrtle oil, 6 parts of ardisia crenata and 3 parts of dark plum pulp.
5. The platycodon grandiflorum particles for treating a respiratory disease caused by haze according to claim 1, wherein: the material is mainly prepared from the following raw materials in parts by weight:
15 parts of platycodon grandiflorum polysaccharide, 5 parts of thyme leaf, 4 parts of perilla seed extract, 3 parts of mullein extract, 10 parts of myrtle oil, 2 parts of ardisia crenata and 1 part of dark plum pulp.
6. The platycodon grandiflorum particles for treating a respiratory disease caused by haze according to claim 1, wherein: the material is mainly prepared from the following raw materials in parts by weight:
20 parts of platycodon grandiflorum polysaccharide, 7.5 parts of thyme leaf, 6 parts of perilla seed extract, 5 parts of mullein extract, 12.5 parts of myrtle oil, 4 parts of ardisia crenata and 2 parts of dark plum pulp.
7. The preparation method of the platycodon grandiflorum particles for treating the respiratory diseases caused by haze as claimed in claims 1 to 6, wherein the platycodon grandiflorum particles comprise the following components in percentage by weight: the method comprises the following steps:
s1, respectively carrying out ultramicro grinding on the weighed thyme leaves, ardisia crenata and dark plum flesh to 200 meshes for later use;
s2, placing the obtained thyme leaf powder and the ardisia crenata sims powder into a high-pressure reaction kettle, adding a proper amount of purified water, performing subcritical water extraction treatment for 30-40 min at 100-150 ℃, performing centrifugal separation, and performing vacuum concentration on the obtained supernatant to obtain an extract;
s3, mixing the obtained extract with platycodon grandiflorum polysaccharide, perilla seed extract, mullein extract and myrtle mixed oil, uniformly stirring, and granulating to obtain particles with the particle size of 20-24 meshes;
s4, placing the smoked plum meat powder in a feed chamber of a coating granulator, placing the obtained particles in a rolling pot of a centrifugal granulator, starting a machine by using 3% hydroxypropyl methylcellulose as an adhesive, preparing drug-loaded pellets by adopting a powder lamination method, opening a discharge port when the drug-loaded pellets are 24-30 meshes, taking out the finished product, drying at 40 ℃, and screening by using a standard sieve to obtain the smoked plum drug-loaded pellets.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110567539.5A CN113181263A (en) | 2021-05-24 | 2021-05-24 | Platycodon grandiflorum particles for treating respiratory system diseases caused by haze and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110567539.5A CN113181263A (en) | 2021-05-24 | 2021-05-24 | Platycodon grandiflorum particles for treating respiratory system diseases caused by haze and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113181263A true CN113181263A (en) | 2021-07-30 |
Family
ID=76985029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110567539.5A Pending CN113181263A (en) | 2021-05-24 | 2021-05-24 | Platycodon grandiflorum particles for treating respiratory system diseases caused by haze and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113181263A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113616756A (en) * | 2021-09-15 | 2021-11-09 | 咸阳职业技术学院 | Chinese herbal medicine composition for treating porcine epidemic diarrhea |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528857A (en) * | 2018-11-30 | 2019-03-29 | 哈工大机器人（山东）智能装备研究院 | A kind of campanulaceae particle and preparation method thereof for treating respiratory disease caused by haze |
| CN110583826A (en) * | 2019-08-14 | 2019-12-20 | 中国农业科学院农产品加工研究所 | Haze-preventing lung-heat-clearing cough-relieving tea and preparation method thereof |
| CN111358846A (en) * | 2020-05-14 | 2020-07-03 | 西安市胸科医院 | Medicament for improving central nervous system inflammation |
| CN112274567A (en) * | 2020-10-27 | 2021-01-29 | 安徽康信制药股份有限公司 | Licorice root and platycodon root granules and preparation method thereof |
-
2021
- 2021-05-24 CN CN202110567539.5A patent/CN113181263A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109528857A (en) * | 2018-11-30 | 2019-03-29 | 哈工大机器人（山东）智能装备研究院 | A kind of campanulaceae particle and preparation method thereof for treating respiratory disease caused by haze |
| CN110583826A (en) * | 2019-08-14 | 2019-12-20 | 中国农业科学院农产品加工研究所 | Haze-preventing lung-heat-clearing cough-relieving tea and preparation method thereof |
| CN111358846A (en) * | 2020-05-14 | 2020-07-03 | 西安市胸科医院 | Medicament for improving central nervous system inflammation |
| CN112274567A (en) * | 2020-10-27 | 2021-01-29 | 安徽康信制药股份有限公司 | Licorice root and platycodon root granules and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113616756A (en) * | 2021-09-15 | 2021-11-09 | 咸阳职业技术学院 | Chinese herbal medicine composition for treating porcine epidemic diarrhea |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108096423B (en) | A Chinese medicinal composition for treating hypertension, hyperlipidemia, and hyperglycemia, and its preparation method | |
| CN113181263A (en) | Platycodon grandiflorum particles for treating respiratory system diseases caused by haze and preparation method thereof | |
| CN104940485A (en) | Traditional Chinese medicine composition for treating infantile asthma and preparation method thereof | |
| CN113244311B (en) | Pharmaceutical composition for treating cutaneous pruritus after hemodialysis and preparation method thereof | |
| CN103041151A (en) | Traditional Chinese medicine composition for curing trachitis and preparation method thereof | |
| CN109646562A (en) | A kind of slug compound preparation and preparation method thereof for preventing and treating COPD | |
| CN1073439C (en) | Medicine for treating trachitis and asthma and its preparation | |
| CN103768471B (en) | A kind of Chinese medicine composition of cough-relieving and its preparation method and application | |
| CN105125838A (en) | Traditional Chinese medicine composite for treating infantile asthma and preparing method thereof | |
| CN104435644A (en) | Traditional Chinese medicine preparation for treating asthma as well as preparation method and application of traditional Chinese medicine preparation | |
| CN104906337B (en) | A kind of Radix Glycyrrhizae pear Bulbus Fritillariae Ussuriensis and preparation method | |
| CN116077602B (en) | Dai medicine composition, medicine preparation, preparation method and application thereof | |
| CN108498700A (en) | A kind of Chinese medicine composition and preparation method thereof for treating cough | |
| CN115212247B (en) | Preparation of nitraria tangutorum bobr and application thereof | |
| CN111939263B (en) | Pharmaceutical composition, traditional Chinese medicine composition, extract thereof, preparation, medicament and application | |
| CN110585281B (en) | Children and adults common traditional Chinese medicine preparation for treating phlegm-heat obstructing lung and preparation method thereof | |
| CN101485850A (en) | Pharmaceutical composition for resolving phlegm and suppressing cough and technique for preparing the same | |
| CN110946958A (en) | Traditional Chinese medicine component for treating chronic obstructive pulmonary disease | |
| CN106620440B (en) | Prescription for cough | |
| CN116870047A (en) | Composite medicament for inhibiting respiratory syncytial virus and preparation method thereof | |
| CN116889604A (en) | Traditional Chinese medicine pill for treating allergic asthma and preparation process thereof | |
| CN104258033A (en) | Traditional Chinese medicine preparation for treating chronic bronchitis at acute stage | |
| CN1319583C (en) | Medicine for treating lung cancer and preparing process thereof | |
| CN111773369A (en) | Decoction for conditioning small cell lung cancer and preparation method thereof | |
| CN107596107A (en) | A kind of clearing heat, relieving sore-throat antiallergy Chinese medicine preparation and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210730 |