CN104258033A - Traditional Chinese medicine preparation for treating chronic bronchitis at acute stage - Google Patents
Traditional Chinese medicine preparation for treating chronic bronchitis at acute stage Download PDFInfo
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Abstract
The invention relates to a medicine combination for treating chronic bronchitis at an acute stage (syndrome of phlegm-heat obstructing lung). The medicine combination is prepared from traditional Chinese medicines, and uses tansymustard seeds, honeyed Chinese ephedrine, tendrilleaf fritillary bulbs, bitter almonds, pericarpium trichosanthis, plaster, baical skullcap roots, heartleaf houttuynia herbs, inula flowers, ochre, ginkgoes, geckos, ballonflower and licorice roots as raw materials. The method for preparing the medicine combination comprises the following steps: adding ethyl alcohol to the tansymustard seeds and the bitter almonds, performing regurgitation extraction and water extraction, concentrating the solution containing the tansymustard seeds, the bitter almond and the ethyl alcohol, mixing fine powder formed by crushing the plaster and the ochre with the solution for making particles, drying and crushing the particles, uniformly mixing the crushed particles with fine powder of surplus medicines, and processing the crushed particles and the fine powder of the surplus medicines to prepare powder, honeyed pills, capsules, tablets and the like. The medicine disclosed by the invention has the efficacies of clearing away the lung for reducing phlegm and relieving cough and asthma, and has an obvious effect on treating the chronic bronchitis at the acute stage (the syndrome of phlegm-heat obstructing lung), the treatment effective rate reaches more than 98.5%, and no obvious untoward reactions is found.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine preparation for the acute episode of chronic bronchitis phase.
Background technology
Chronic bronchitis is commonly encountered diseases, the frequently-occurring disease of respiratory system, and in normal population, total incidence is 3.0 ~ 6.6% according to statistics, and the prevalence of more than 50 years old is 14.2 ~ 18%.Along with environmental pollution is more and more serious, sickness rate is still in the trend risen year by year.Its clinical characters be recurrent exerbation cough, cough up phlegm or with panting, along with the development of the state of an illness, and occur the complication such as emphysema, pulmonary hypertension, pulmonary heart disease, until life threatening.
Modern medicine is thought: infection, cold, dust, smog, harmful gas etc. are the common causative factors of " chronic bronchitis ".And Traditional Chinese Medicine belongs to the category such as " cough ", " phlegm syndrome ", " fluid-retention syndrome ", " the syndrome of dyspnea ", emphasize that diseases caused by exogenous pathogenic factor seasonal pathogen, cold impairing the lung are for outside its inducement, intrinsic factor lose a surname mainly due to qiactivity of triple energizer, and yang deficiency water liquid is not transported and caused.Plain Questions of Huangdi's Internal Classic coughs an opinion section: " vital organs of the human body all can make us coughing, and non-only lung also ".Lung occupies the part of the body cavity above the diaphragm housing the heart and lungs, can regulating fluid apssage; The spleen being located in middle-JIAO, can transmit essence of water and grain; Kidney occupies the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, can evaporate water liquid, separating clear and excreting turbid.Three dirty malfunctions, then water liquid gathers for drink is expectorant.It can thus be appreciated that primary disease shows as lung, spleen, kidney three deficiency of five ZANG-organs damage, and their intercoordinations are unbalance, simultaneously again because of the participation more sophisticated of the factors such as expectorant, wet, cold, the stasis of blood.
And although existing cough suppressing panting calming medicine is a lot, Western medicine instant effect, successful, cure the symptoms, not the disease, untoward reaction be many, easy generation drug resistance etc.The existing Chinese patent medicine efficacy of a drug is mild, and the medicine for the acute episode of chronic bronchitis phase is not enough and weak effect.According to the feature of acute episode of chronic bronchitis phase (syndrome of phlegm-heat obstructing lung), determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, reasonable formula is the key of disease therapy.
Summary of the invention
The object of the present invention is to provide a kind of drug regimen being used for the treatment of the acute attack stage of chronic bronchitis, this medicine can reduce phlegm by relieving cough and asthma fast, simultaneously extensive, the production technology in medicine source is simply easy to reappear, without obvious untoward reaction, make up the deficiency of existing medicine.
The present invention relates to a kind of drug regimen being used for the treatment of the acute episode of chronic bronchitis phase taking Chinese medicine as raw material and prepare, it is characterized in that it is made up of the raw material of following weight proportion:
Semen Lepidii (Semen Descurainiae): 20 ~ 60 parts, Herba ephedrae: 5 ~ 30 parts,
Bulbus Fritillariae Cirrhosae: 5 ~ 30 parts, Semen Armeniacae Amarum: 20 ~ 80 parts,
Pericarpium Trichosanthis: 5 ~ 30 parts, Gypsum Fibrosum: 30 ~ 100 parts,
Radix Scutellariae: 10 ~ 40 parts, Herba Houttuyniae: 30 ~ 100 parts,
Flos Inulae: 10 ~ 40 parts, Haematitum: 10 ~ 40 parts,
Semen Ginkgo: 5 ~ 20 parts, Gecko: 30 ~ 100 parts,
Radix Platycodonis: 10 ~ 50 parts, Radix Glycyrrhizae: 10 ~ 50 parts.
The present invention relates to a kind of drug regimen being used for the treatment of the acute episode of chronic bronchitis phase taking Chinese medicine as raw material and prepare, its optimal proportion is that raw material components comprises following composition by weight ratio:
Semen Lepidii (Semen Descurainiae): 40 ~ 60 parts, Herba ephedrae: 5 ~ 10 parts,
Bulbus Fritillariae Cirrhosae: 15 ~ 30 parts, Semen Armeniacae Amarum: 30 ~ 40 parts,
Pericarpium Trichosanthis: 20 ~ 30 parts, Gypsum Fibrosum: 50 ~ 70 parts,
Radix Scutellariae: 30 ~ 45 parts, Herba Houttuyniae: 50 ~ 70 parts,
Flos Inulae: 15 ~ 20 parts, Haematitum: 15 ~ 20 parts,
Semen Ginkgo: 5 ~ 15 parts, Gecko: 40 ~ 60 parts,
Radix Platycodonis: 15 ~ 30 parts, Radix Glycyrrhizae: 15 ~ 30 parts.
For the Chinese medicine preparation of acute episode of chronic bronchitis phase, or be powder, or be honeyed pill, or be capsule, or be tablet.
The production method of medicine of the present invention is: Semen Lepidii (Semen Descurainiae), Semen Armeniacae Amarum add alcohol reflux, filter, filtrate is condensed into clear paste, and medicinal residues are extracting in water again, filters, filtrate is condensed into clear paste, merging filtrate, the fine powder mixing granulation after pulverizing with Gypsum Fibrosum, Haematitum, crushed after being dried, mix homogeneously with ten taste fine powders such as remaining Herba ephedrae, be processed into powder, honeyed pill, capsule, tablet etc.
Cough with asthma one, to being called as obstinate disease, is recorded a lot in document ancient books.The opinion of cough with asthma is started in "Nei Jing", is dispersed in all sections by the syndrome of dyspnea." a Jing Yue's complete work cough section " cloud: " cough want, only only two, one say diseases caused by exogenous pathogenic factor, one say internal injury and use up." like this, too numerous to mention.But the systematically discussing that the cause of disease of cough with asthma, pathogenesis, opinion are controlled, then head sees treatise on Febrile Diseases, " Medical Treasures of the Golden Chamber ".Chronic bronchitis belongs to the category such as " cough ", " phlegm syndrome ", " fluid-retention syndrome ", " the syndrome of dyspnea " in the traditional Chinese medical science, and diseases caused by exogenous pathogenic factor seasonal pathogen, cold impairing the lung are outside its inducement, and intrinsic factor lose a surname mainly due to qiactivity of triple energizer, and yang deficiency water liquid is not transported and caused.Traditional Chinese Medicine thinks that lung occupies the part of the body cavity above the diaphragm housing the heart and lungs, can regulating fluid apssage; The spleen being located in middle-JIAO, can transmit essence of water and grain; Kidney occupies the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, can evaporate water liquid, separating clear and excreting turbid.Three dirty malfunctions, then water liquid gathers for drink is expectorant.It can thus be appreciated that primary disease shows as lung, spleen, kidney three deficiency of five ZANG-organs damage, and their intercoordinations are unbalance, simultaneously again because of the participation more sophisticated of the factors such as expectorant, wet, cold, the stasis of blood.The traditional Chinese medical science is particular about determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the Therapeutic Method that different card marquis is corresponding different.
Solution of the present invention is based on the understanding of motherland's traditional medicine to chronic bronchitis, in conjunction with the modern Empirical formula forming treatment acute episode of chronic bronchitis phase (syndrome of phlegm-heat obstructing lung) about research data and clinical practice, in prescription, with Semen Lepidii (Semen Descurainiae) eliminating pathogen from the lung for relieving asthma, line water detumescence is monarch drug, with Herba ephedrae, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Gypsum Fibrosum for minister, then helps monarch-minister drug altogether with Radix Scutellariae, Herba Houttuyniae, heat-clearing and toxic substances removing, removing heat from the lung and dissipating phlegm.Bulbus Fritillariae Cirrhosae merit in clearing heat and moistening lung, preventing phlegm from forming and stopping coughing, open the pent-up of mental disorder, Flos Inulae, Haematitum lowering the adverse flow of QI, Radix Platycodonis medicine carrying enters lung, through sick institute, and Semen Ginkgo is astringed the lung and reinforces the kidney, the kidney invigorating of Gecko lung benefiting, and residence is attacked in benefit, attacks heresy and is not just hindering, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.During acute episode of chronic bronchitis, positive QI-insufficiency is deposited with the real expectorant heat of mark often, we according to the principle of " symptomatic treatment in acute condition ", held back loose, have to rise to have and fall, attacked benefit, the product of slightly assistant righting while the pathogenic factor that eliminates the phlegm, reinforcement and elimination in combination, to attack, attacks and does not just hinder, tonify without causing stagnation, a surname does not consume gas, does not puckeryly stay heresy, and all medicines share, play removing heat from the lung and dissipating phlegm altogether, the merit of relieving cough and asthma.For the acute episode of chronic bronchitis phase, the acute cough of the cloudy mechanism of qi of phlegm-heat obstructing in the lung, expectorant is a kind of well medicine for treatment.
Detailed description of the invention
Embodiment 1:
Semen Lepidii (Semen Descurainiae): 4 ~ 6kg, Herba ephedrae: 0.5 ~ 1kg,
Bulbus Fritillariae Cirrhosae: 1.5 ~ 3kg, Semen Armeniacae Amarum: 3 ~ 4kg,
Pericarpium Trichosanthis: 2 ~ 3kg, Gypsum Fibrosum: 5 ~ 7kg,
Radix Scutellariae: 3 ~ 4.5kg, Herba Houttuyniae: 5 ~ 7kg,
Flos Inulae: 1.5 ~ 2kg, Haematitum: 1.5 ~ 2kg,
Semen Ginkgo: 0.5 ~ 1.5kg, Gecko: 4 ~ 6kg,
Radix Platycodonis: 1.5 ~ 3kg, Radix Glycyrrhizae: 1.5 ~ 3kg.
Get said medicine Semen Lepidii (Semen Descurainiae), Semen Armeniacae Amarum adds alcohol reflux, filter, filtrate is condensed into clear paste, and medicinal residues are extracting in water again, filters, filtrate is condensed into clear paste, merging filtrate, the fine powder mixing granulation after pulverizing with Gypsum Fibrosum, Haematitum, crushed after being dried, mix homogeneously with ten taste fine powders such as remaining Herba ephedrae, be processed into powder.
Embodiment 2: Semen Lepidii (Semen Descurainiae): 4 ~ 6kg, Herba ephedrae: 0.5 ~ 1kg,
Bulbus Fritillariae Cirrhosae: 1.5 ~ 3kg, Semen Armeniacae Amarum: 3 ~ 4kg,
Pericarpium Trichosanthis: 2 ~ 3kg, Gypsum Fibrosum: 5 ~ 7kg,
Radix Scutellariae: 3 ~ 4.5kg, Herba Houttuyniae: 5 ~ 7kg,
Flos Inulae: 1.5 ~ 2kg, Haematitum: 1.5 ~ 2kg,
Semen Ginkgo: 0.5 ~ 1.5kg, Gecko: 4 ~ 6kg,
Radix Platycodonis: 1.5 ~ 3kg, Radix Glycyrrhizae: 1.5 ~ 3kg.
Get said medicine Semen Lepidii (Semen Descurainiae), Semen Armeniacae Amarum adds alcohol reflux, filter, filtrate is condensed into clear paste, and medicinal residues are extracting in water again, filters, filtrate is condensed into clear paste, merging filtrate, the fine powder mixing granulation after pulverizing with Gypsum Fibrosum, Haematitum, crushed after being dried, mix homogeneously with ten taste fine powders such as remaining Herba ephedrae, directly incapsulate.
Embodiment 3:
Semen Lepidii (Semen Descurainiae): 4 ~ 6kg, Herba ephedrae: 0.5 ~ 1kg,
Bulbus Fritillariae Cirrhosae: 1.5 ~ 3kg, Semen Armeniacae Amarum: 3 ~ 4kg,
Pericarpium Trichosanthis: 2 ~ 3kg, Gypsum Fibrosum: 5 ~ 7kg,
Radix Scutellariae: 3 ~ 4.5kg, Herba Houttuyniae: 5 ~ 7kg,
Flos Inulae: 1.5 ~ 2kg, Haematitum: 1.5 ~ 2kg,
Semen Ginkgo: 0.5 ~ 1.5kg, Gecko: 4 ~ 6kg,
Radix Platycodonis: 1.5 ~ 3kg, Radix Glycyrrhizae: 1.5 ~ 3kg.
Get said medicine Semen Lepidii (Semen Descurainiae), Semen Armeniacae Amarum adds alcohol reflux, filter, filtrate is condensed into clear paste, and medicinal residues are extracting in water again, filter, filtrate is condensed into clear paste, merging filtrate, the fine powder mixing granulation after pulverizing with Gypsum Fibrosum, Haematitum, crushed after being dried, mix homogeneously with ten taste fine powders such as remaining Herba ephedrae, add 20kg Mel, make honeyed pill.
The scope that the consumption of above raw material can also describe according to description adjusts.
Clinical research data of the present invention is as follows:
Adopt random open, positive drug contrast clinical trial, the age 18-68 year between, men and women does not limit.
Diagnostic criteria:
Chronic bronchitis: cough clinically, expectoration is cardinal symptom or with panting, annual morbidity continues three months, and continuous 2 years or more (getting rid of other reasons to cause, as pulmonary tuberculosis, pneumoconiosis, pulmonary abscess, bronchial asthma, bronchiectasis, heart disease, cardiac insufficiency, chronic naso-pharynageal disease, pulmonary carcinoma etc.).
Acute attack stage: occur purulence or mucus purulent sputum in one week, amount of expectoration obviously increases, or with the performance of the inflammation such as heating, or cough in one week, expectorant or breathe heavily any one symptom and obviously aggravate, or critically ill patient obviously adds severe one.
Syndrome of phlegm-heat obstructing lung: cough, expectoration, pant and glue with expectorant, uncomfortable in chest, itching throat or pain, xerostomia, constipation two or more symptoms.
Therapeutic Method: each 1.5 grams, every day three times, takes after the meal, serve on seven days.
Evaluation criterion:
Clinic control: expectorant, cough, breathe heavily recover normal or return to acute attack before level, comprehensive therapeutic effect index >=95%.
Effective: expectorant, to cough, breathe heavily and significantly alleviate, 70%≤comprehensive therapeutic effect index < 95%.
Effective: expectorant, to cough, breathe heavily to have and alleviate, 30%≤comprehensive therapeutic effect index < 70%.
Invalid: expectorant, cough, breathe heavily without change or increase the weight of, comprehensive therapeutic effect index < 30%.
Integration * 100% before comprehensive therapeutic effect index=(before treatment the rear integration of integration-treatment)/treatment
Therapeutic outcome:
| Group | Total case load | Face control | Effective | Effectively | Invalid | Effective percentage (%) |
| Treatment group | 340 | 130 | 106 | 99 | 5 | 98.5 |
| Matched group | 110 | 35 | 28 | 34 | 13 | 88.2 |
| P value | ? | ? | ? | ? | ? | ＞0.05 |
In above-mentioned therapeutic process, by acute attack stage (syndrome of phlegm-heat obstructing lung) patient 340 example of Drug therapy chronic bronchitis of the present invention, clinic control rate 38.2%, the aobvious rate 69.4% of control, total effective rate 98.5%; By positive control drug patient 110 example, clinic control rate 31.8%, the aobvious rate 57.3% of control, total effective rate 88.2%.Curative effect is significantly better than matched group through statistical analysis treatment group.
Not occurring producing safety issue because taking Experimental agents in whole clinical experiment process, there is a routine adverse events (flu) in treatment group, and a routine adverse events (diarrhoea) appears in matched group, judges after deliberation to have nothing to do with drug administration.Visible safety of medicine of the present invention is reliable.
Representative instance:
Wang, man, 65 years old, to cough, the recurrent exerbation 3 years of stridulating, because of suffering from cold, the state of an illness is shown effect again, increases the weight of to go to a doctor over 2 days, and private prosecution is thirsty, dry pharynx, yellowish urine, be hard and dry.Have a medical check-up: mind is clear, spirit is poor, and Mild cough, has yellow sputum, and idol is stridulated, body temperature 38.5 DEG C, red tongue with yellow fur, slippery and rapid pulse, two lung audible and be dispersed in dry, moist rale on a small quantity.Have a blood test, urine, feces routine, hepatic and renal function, electrocardiogram be all normal.This medicine of one after each meal ormal weight, coughed two days later and slightly subtracted every day, and body temperature is down to 36.7 DEG C, and after three days, amount of expectoration reduces, and thirsty, dry pharynx, yellowish urine, was hard and dry and healed.Two lung is dry, moist rale disappears.After seven days, only tongue arteries and veins is as front, and remaining disease disappears.Check total white blood cells 9.2*10
9/ L, neutrophilic granulocyte 74%.Pulmonary function test PEF 3.38L/S, MEF 2.61L/S, FEV1 1.97L/S, FEV1% 86.4%.Comprehensive grading treats first 30 points, and treat latter 1 point, curative effect belongs to clinic control.
Experimental session patient have no adverse reaction.Liver and kidney function before and after treatment, electrocardiogram, defecation routine examination is normal.
The above embodiment only have expressed the specific embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.
The present invention relates to a kind of drug regimen being used for the treatment of acute episode of chronic bronchitis phase (syndrome of phlegm-heat obstructing lung) taking Chinese medicine as raw material and prepare, it is by Semen Lepidii (Semen Descurainiae), Herba ephedrae, Bulbus Fritillariae Cirrhosae, Semen Armeniacae Amarum, Pericarpium Trichosanthis, Gypsum Fibrosum, Radix Scutellariae, Herba Houttuyniae, Flos Inulae, Haematitum, Semen Ginkgo, Gecko, Radix Platycodonis, Radix Glycyrrhizae is raw material, wherein Semen Lepidii (Semen Descurainiae), Semen Armeniacae Amarum adds alcohol reflux, water extraction, with Gypsum Fibrosum after concentrated, fine powder mixing granulation after Haematitum pulverizing, crushed after being dried, mix homogeneously with residue flavour of a drug fine powder, be processed into powder, honeyed pill, capsule, tablet etc.Medicine of the present invention has effect of removing heat from the lung and dissipating phlegm, relieving cough and asthma, is used for the treatment of the acute episode of chronic bronchitis phase (syndrome of phlegm-heat obstructing lung) to have positive effect, and its treated effect reaches more than 98.5%, and does not find any obvious untoward reaction.
Claims (3)
1. for the Chinese medicine preparation of acute episode of chronic bronchitis phase, it is characterized in that, raw material components comprises following composition by weight ratio:
Semen Lepidii (Semen Descurainiae): 20 ~ 60 parts, Herba ephedrae: 5 ~ 30 parts,
Bulbus Fritillariae Cirrhosae: 5 ~ 30 parts, Semen Armeniacae Amarum: 20 ~ 80 parts,
Pericarpium Trichosanthis: 5 ~ 30 parts, Gypsum Fibrosum: 30 ~ 100 parts,
Radix Scutellariae: 10 ~ 40 parts, Herba Houttuyniae: 30 ~ 100 parts,
Flos Inulae: 10 ~ 40 parts, Haematitum: 10 ~ 40 parts,
Semen Ginkgo: 5 ~ 20 parts, Gecko: 30 ~ 100 parts,
Radix Platycodonis: 10 ~ 50 parts, Radix Glycyrrhizae: 10 ~ 50 parts.
2. a kind of Chinese medicine preparation for the acute episode of chronic bronchitis phase according to claim 1, is characterized in that, its proportioning is that raw material components comprises following composition by weight ratio:
Semen Lepidii (Semen Descurainiae): 40 ~ 60 parts, Herba ephedrae: 5 ~ 10 parts,
Bulbus Fritillariae Cirrhosae: 15 ~ 30 parts, Semen Armeniacae Amarum: 30 ~ 40 parts,
Pericarpium Trichosanthis: 20 ~ 30 parts, Gypsum Fibrosum: 50 ~ 70 parts,
Radix Scutellariae: 30 ~ 45 parts, Herba Houttuyniae: 50 ~ 70 parts,
Flos Inulae: 15 ~ 20 parts, Haematitum: 15 ~ 20 parts,
Semen Ginkgo: 5 ~ 15 parts, Gecko: 40 ~ 60 parts,
Radix Platycodonis: 15 ~ 30 parts, Radix Glycyrrhizae: 15 ~ 30 parts.
3. a kind of Chinese medicine preparation for the acute episode of chronic bronchitis phase according to claim 1 and 2, is characterized in that: or be powder, or be honeyed pill, or be capsule, or be tablet.
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| CN104547493A (en) * | 2015-01-16 | 2015-04-29 | 解耀锃 | Chinese medicinal composition for treating acute exacerbation of chronic bronchitis |
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