CN1233408C - Tablet medicine for treating pharyngolaryngitis and its preparation method - Google Patents
Tablet medicine for treating pharyngolaryngitis and its preparation method Download PDFInfo
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- CN1233408C CN1233408C CN 200410022015 CN200410022015A CN1233408C CN 1233408 C CN1233408 C CN 1233408C CN 200410022015 CN200410022015 CN 200410022015 CN 200410022015 A CN200410022015 A CN 200410022015A CN 1233408 C CN1233408 C CN 1233408C
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Abstract
The present invention discloses tablet medicine for treating pharyngitis diseases and a preparation method thereof. The present invention is characterized in that water with a quantity of 6 times of the total weight of four kinds of medicine of emblic leafflower fruit, blackberrykiky rhizome, giant knotweed and liquorice is added. The medicine is decocted twice, and every time is 2 hours. The raw materials are filtered, and filtrate is merged and stood for 24 hours to obtain supernatant liquid which is concentrated to 1.25 to 1.35 of relative density at a temperature of 20 DEG C. Then, four raw materials of menthol, cane sugar, methylene blue and lemon yellow are taken for serving as supplementary materials. The cane sugar is pulverized into fine powder, and is sieved by a sieve of 60 meshes. Cane sugar powder, methylene blue and lemon yellow are added in extractum and uniformly mixed to make particles which are dried at a temperature of 80 DEG C. The menthol is dissolved by ethanol, and then is uniformly mixed with particles. Finished products are obtained through granulation and pressing into tablets. The present invention has the advantage of good curative effects for treating acute and chronic pharyngitis diseases.
Description
Technical field:
The present invention relates to a kind of sore-throat relieving lozenge medicine for the treatment of acute and chronic pharyngitis and preparation method thereof, belong to the field of Chinese medicines.
Background technology:
Acute and chronic pharyngitis is one of common respiratory tract disease, and outbreak influences feed, breathes and sleep because of violent pain often.Though it is more to treat the medicine of this disease at present, but ubiquity the less-than-ideal problem of curative effect, as treat being usually used in of selling on the market acute and chronic pharyngitis, trade name is the medicine of " Herba Pileae Scriptae Tabellae ", this medicine in use, its curative effect still can not be satisfactory.
Summary of the invention:
The objective of the invention is: provide the acute and chronic pharyngitis curative effect of disease of a kind of treatment sore-throat relieving lozenge medicine and preparation method thereof preferably, to overcome the deficiencies in the prior art.
The present invention is achieved in that its sore-throat relieving lozenge medicine mainly made by Fructus Phyllanthi, Rhizoma Belamcandae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae four Chinese medicine thing, and each herbal medicine is respectively by weight ratio: 150～310 parts of Fructus Phyllanthis, 18～22 parts of Rhizoma Belamcandae, 18～22 parts of Rhizoma Polygoni Cuspidati, 9～11 parts in Radix Glycyrrhizae; Each herbal medicine best proportioning by weight is: 280 parts of Fructus Phyllanthis, 20 parts of Rhizoma Belamcandae, 20 parts of Rhizoma Polygoni Cuspidati, 10 parts in Radix Glycyrrhizae; The preparation method of its sore-throat relieving lozenge medicine is: the gross weight by Fructus Phyllanthi, Rhizoma Belamcandae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae four Chinese medicine adds 6 times of water gagings, decocts twice, each 2 hours, filter, merging filtrate left standstill 24 hours, get supernatant, it is concentrated into that relative density surveys under 20 ℃ of temperature be 1.25～1.35; Get Mentholum, sucrose, serge blue, four kinds of raw materials of lemon yellow then as adjuvant; each adjuvant proportioning by weight is: 1.2～1.8 parts of Mentholums, 450～550 parts of sucrose, 0.01～0.03 part of serge blue, 0.08～0.12 part of lemon yellow; cane sugar powder is broken into fine powder; cross 60 mesh sieves; cane sugar powder, serge blue, lemon yellow are added in the extractum; mixing; make granule; and it is dry under 80 ℃ of temperature; with Mentholum with dissolve with ethanol after with the granule mixing, and get product through granulate, after being pressed into tablet.
Adopt four Chinese medicine thing component of the present invention also can add various conventional adjuvant required when preparing different dosage form, as collapse slow agent, lubricant, binding agent etc. and be prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine, as pill, powder, capsule, oral liquid etc.
According to the theory of the traditional Chinese medical science, disease that the present invention adapts to, the cause of disease, pathogenesis and the rule of treatment are:
It is acute inflammation of the throat (acute pharyngitis), chronic throat obstruction, chronic pharyngitis (chronic pharyngitis) that the present invention adapts to disease.Its clinical manifestation is a red swelling of the pharynx pain, pharyngeal dryness and heat, dysphagia or the pharyngeal red discomfort of itching, cardinal symptom such as thirsty.Chinese medicine is thought, the formation of laryngopharyngeal diseases all has qi depression to blood stasis in various degree, through the pathological change of BI-syndrome involved the blood vessels resistance.So " miscellaneous diseases source and course rhinoceros is turbid " volume 24 is said: " sore throat, numbness person close also, must swell very the throat obturation." " ophthalmology heart method " add: " all rednesses are invisible to be numbness, and tangible is moth." main symptom that spells out sore throat is a red swelling of the pharynx pain, or little red itching throat discomfort.Get to the bottom of sb.'s illness and many attack lung, or the prolonged illness YIN-deficiency of the lung and kidney with wind heat, weather drastic change, daily life is careless, and lung is defended and is lost admittedly, and the wind-heat evil toxin infringement of taking advantage of a weak point in opponent's defence is directly attacked due to the throat from mouth and nose.The pathogenic factor internal injury is fought mutually and is not gone in lung, causes laryngopharynx swelling and pain, dysphagia, and hinder in the bright Tianjin of heat, and then dry pharynx is scorching; Sick deficiency of body fluid for a long time, hyperactivity of deficient fire follows through last steaming, stifling throat, pharyngalgia itching throat then, does not moisten less in Tianjin, and then dry pharynx is uncomfortable and thirsty.So the pathogenesis of sore throat is to invade outward because of wind heat, the lung-heat impairment of body fluid, pharynx network numbness hinders and causes.Treatment is worked as with relieving sore-throat by clearing away heat, reducing swelling and alleviating pain, and promoting the production of body fluid to moisturize is the basic rule of treatment.The present invention promptly sends medicine according to this reason system side.
Fang Xiewei of the present invention:
According to the understanding of the above-mentioned sore throat cause of disease, pathogenesis, method of treatment, Fructus Phyllanthi among the side of the present invention, bitter in the mouth, sweet, cold attaches to the lung and stomach meridians.Have removing heat from the lung and relieving sorethroat, the merit of the cough-relieving of promoting the production of body fluid, " Newly Revised Canon of Materia Medica ": " Fructus Phyllanthi, bitter in the mouth, sweet, cold, nontoxic.Main air deficiency-heat gas ", " Chinese Clinical Chinese Materia Medica ": " this product is sweet, cold, relieving sore-throat by clearing away heat, nourishing the lung to arrest cough is used for laryngopharynx swelling and pain ", " Guizhou Chinese herbal medicine resource ": " Fructus Phyllanthi acts as expectorant, and pharyngalgia is controlled in the cough-relieving detoxifcation " and be monarch drug; Rhizoma Belamcandae, bitter, cold, return lung meridian.Merit with heat-clearing and toxic substances removing, dispelling phlegm and relieving sore-throat, " herbal classic ": " controlling cough with dyspnea, the sore throat pharyngalgia ", Compendium of Material Medica: " Rhizoma Belamcandae energy pathogenic fire reducing is a key medicine so ancient prescription is controlled the sore throat pharyngalgia " is ministerial drug, assists the merit of monarch drug relieving sore-throat by clearing away heat; Rhizoma Polygoni Cuspidati, bitter, cold, return lung, liver, gallbladder meridian, have the merit of heat-clearing and toxic substances removing, expelling phlegm for arresting cough, " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " attack all toxic swellings, only have sore throat, diuresis is walked meridians ", and being adjuvant drug, assistant helps monarch-minister drug heat-clearing and toxic substances removing, the power of reducing swelling and alleviating pain; Radix Glycyrrhizae, sweet, flat, GUIXIN, lung, spleen, stomach warp.Have heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the merit of relieving spasm to stop pain, the blending property of medicine, " book on Chinese herbal medicine just ": " property that (Radix Glycyrrhizae) must neutralize has the merit of transferring benefits, thus poison get separate its poison, firm medicine gets its property of sum ", be adjuvant.All medicines share, the effect of gather removing heat from the lung and relieving sorethroat, reducing swelling and alleviating pain altogether, promoting the production of body fluid and moisturizing.Be suitable for the hyperactivity of deficient fire disease of the wind-heat syndrome and the chronic throat obstruction, chronic pharyngitis of acute inflammation of the throat.
Therefore the present invention have promote the production of body fluid moisturize, the function of removing heat from the lung and relieving sorethroat, reducing swelling and alleviating pain, be used for the treatment of acute inflammation of the throat (acute pharyngitis), chronic throat obstruction, chronic pharyngitis diseases such as (chronic pharyngitiss) has better curative effect.
The specific embodiment:
Embodiments of the invention: get Fructus Phyllanthi 280 grams, Rhizoma Belamcandae 20 grams, Rhizoma Polygoni Cuspidati 20 grams, Radix Glycyrrhizae 10 grams, add 6 times of water gagings, decoct twice by its gross weight, each 2 hours, filter merging filtrate, left standstill 24 hours, and got supernatant, it is concentrated into that relative density surveys under 20 ℃ of temperature be 1.25～1.35; Get Mentholum 1.5 grams, sucrose 500 grams, serge blue 0.02 gram, lemon yellow 0.1 gram then as adjuvant; cane sugar powder is broken into fine powder; cross 60 mesh sieves; cane sugar powder, serge blue, lemon yellow are added in the extractum; mixing is made granule, and dry under 80 ℃ of temperature; with Mentholum with dissolve with ethanol after with the granule mixing, and get product through granulate, after being pressed into 1000 tablets.
Instructions of taking is: suck each two, 5 times on the 1st.
" throat treasured " the medicine product treatment acute inflammation of the throat and the chronic throat obstruction, chronic pharyngitis that adopt the present invention to produce below by First People's Hospital, Guiyang, and compare with " Herba Pileae Scriptae Tabellae " that pharmaceutical factory in the river, Jiangxi Province produces and to treat the beneficial effect that medicine of the present invention is further set forth in the test of carrying out:
One, object and method
" the acute and chronic pharyngitis clinical verification plan of the precious treatment of throat " diagnosis that draft " new Chinese medicine treatment acute pharyngitis clinical research guideline ", " new Chinese medicine treatment chronic pharyngitis clinical research guideline " and the Guizhou Anshun Pharmaceutical Factory of issuing in 1993 with reference to Ministry of Public Health bureau of drug policy ﹠ administration, select case, grouping, treat and carry out efficacy determination.
(1) clinical case and grouping
Case is from ward, the court and outpatient service totally 80 examples, wherein male 29 examples, women 51 examples, 20～60 years old age, clinical diagnosis acute pharyngitis 60 examples (acute inflammation of the throat wind-heat syndrome 34 examples, lung excess of the stomach heat syndrome 26 examples), chronic pharyngitis 20 examples (chronic throat obstruction, chronic pharyngitis syndrome of flaring up of deficient fire 13 examples, expectorant heat syndrome 7 examples).The simple randomization method of taking to match grouping makes diagnosis, age, sex, the course of disease, the state of an illness of treatment group and matched group close as far as possible, and the treatment group is totally 60 examples, and matched group is totally 20 examples.
(2) Therapeutic Method
The treatment group: suck precious each 2 of throat, 5 times on the 1st, 1 week of acute pharyngitis is a course of treatment, and 4 weeks of chronic pharyngitis are a course of treatment.
Matched group: suck Herba Pileae Scriptae Tabellae, each 1,5 times on the 1st, the course of treatment is consistent with the treatment group.
Points for attention: the Chinese medicine and western medicine of should stopping using during the treatment is sucked, for oral administration and injection anti-infectives.
(3), curative effect determinate standard:
1, acute pharyngitis
Clinical recovery: sx in the medication 3 days, clinical symptoms and sign disappear in 5 days.
Produce effects: sx in the medication 5 days, most of sign disappears.
Effectively: sx in the medication 5 days, the part sign disappears.
Invalid: medication can not make clinical symptoms and sign disappear in one week.
2, chronic pharyngitis
Clinical recovery: sx in the medication 10 days, clinical symptoms and sign disappear in 4 weeks.
Produce effects: sx in 2 weeks of medication, 4 weeks disappeared with interior most of sings and symptoms.
Effectively: sx in the medication 2 days, clinical symptoms and part sign disappear in 4 weeks.
Invalid: clinical symptoms does not have and alleviates or alleviate slightly after the medication, and sign does not have obvious improvement.
Two, result:
(1) rather good with the precious treatment of throat acute pharyngitis 45 examples (acute inflammation of the throat wind-heat syndrome 26 examples, lung excess of the stomach heat syndrome 19 examples) curative effect.General medication after 3 days symptom such as pharyngalgia, dry pharynx and sign obviously alleviate or disappear, most case medications effective disease controlling after 5 days, total effective rate 98% is eliminated clinical symptoms and sign and is compared the photograph medicine and show advantage.During the medication, the heart, liver, kidney, hemopoietic system do not take place and have no side effect in all cases, do not produce the digestive tract irritation yet.
The precious treatment of table 1 throat acute inflammation of the throat (acute pharyngitis) observation of curative effect table
(2) obtain good efficacy with throat precious treatment chronic pharyngitis 15 examples (chronic throat obstruction, chronic pharyngitis syndrome of flaring up of deficient fire 9 examples, expectorant heat syndrome 6 examples), throat is done painful, scorching hot, symptom such as itch and sign and is obviously alleviated or disappear in most of patients medication 1～2 week, total effective rate reaches 93%, period in a medicine, the heart, liver, kidney, hemopoietic system etc. are had no side effect, non-stimulated to digestive tract.
The precious treatment of table 2 throat chronic throat obstruction, chronic pharyngitis (chronic pharyngitis) observation of curative effect table
(3) model case
1, patient Li Hualan, the woman, 32 years old, the office worker suffered from cold one, the violent pharyngalgia that happens suddenly, dysphagia, headache, weak, cough, thick sputum, epistaxis, thirsty polydipsia, appetite descends, heating, it is more dried to defecate, yellowish or reddish urine.Check: see pharyngeal congestion, color is scarlet, the about 1 * 2cm of left submandibular lymph nodes enlargement, and xerocheilia, red tongue, yellow and thin fur, rapid pulse is strong.37.9 ℃ of body temperature, cardiopulmonary ().Liver function is normal, and is large and small just conventional, routine blood test: erythrocyte sum 4,100,000/mm3, hemoglobin 12 (g/g) %; Total white blood cells 12000/mm3 (acidophilia 1%, monokaryon 2% for neutrality 75%, lymph 22%).
Diagnosis: acute sore throat excess-heat syndrome (acute pharyngitis)
With sucking precious each 2 of throat, 5 times on the 1st treatments.Medication pharyngalgia on the 2nd begins to alleviate.Symptoms such as medication pharyngalgia after 3 days, thirsty, headache and pharyngeal sign greatly alleviate, 37.4 ℃ of body temperature, and appetite is normal.After the medication 5 days, the symptom and the sign of its acute pharyngitis all disappear.Result of laboratory test: large and small just conventional normal, liver function is normal, cardiopulmonary (), routine blood test: erythrocyte sum 8,500 ten thousand/mm3 (neutral 65%, lymph 30%, the acidophilia 2%, monokaryon 3%), erythrocyte sum 4,250,000/mm3, hemoglobin 12.3 (g/g) %, 36.9 ℃ of body temperature, recovery from illness is left hospital.
(2) the patient rattan flies, the man, and 21 years old, the driver had the smoking history of drinking history, have sore throat over nearly 3 years and show effect repeatedly, or seek medical advice, or buy treatments such as Herba Pileae Scriptae Tabellae, Co-trimoxazole Tablet by oneself to hospital, can alleviate some symptoms, but pharyngeal uncomfortable all the time, often feel dried itching, the irritative cough.Throat sharp ache after suffering from cold before 2 days, refreshing tired, choke and cough no expectorant, ask drink again and again.Check: pharyngeal congestion is kermesinus, and mucosa is dry, red tongue, and thin fur is few, thready and rapid pulse.37.2 ℃ of body temperature, the heart, lung (), liver function is normal, and large and small just conventional normal, routine blood test is normal.
Diagnosis: chronic throat obstruction, chronic pharyngitis syndrome of flaring up of deficient fire (chronic pharyngitis)
Precious each 2 of buccal throat, 5 treatments every day, medication are after 3 days, and pharynx is painful to be begun to alleviate, and treats for 2 weeks, and pharyngalgia disappears substantially, and idol has cough, and the pharyngeal mucosa color is normal substantially.Around the treatment, transference cures such as pharyngalgia, cough, picture of the tongue, pulse condition are normal; Check: pharyngeal normal, the heart, lung (), liver function is normal, and large and small just conventional normal, routine blood test is normal, 37.0 ℃ of body temperature, disease recovery from illness.
Three, discuss
The precious treatment of throat acute pharyngitis (acute inflammation of the throat), total effective rate reaches 98%, and wherein clinical recovery, obvious effective rate reach 77.8%, control drug Herba Pileae Scriptae Tabellae treatment acute pharyngitis (acute inflammation of the throat) total effective rate 87%, wherein clinical recovery, obvious effective rate are 40%.This shows that the precious comparison of throat is preferable according to the medication effect, onset is very fast, it is more thorough to eliminate relevant symptom and sign.Because this medicine promotes the production of body fluid, sore-throat relieving, analgesic effect are outstanding, having sore throat in elimination has one's own knack aspect drying and other malaise symptoms.
The precious treatment of throat chronic pharyngitis (chronic throat obstruction, chronic pharyngitis) total effective rate is 93%, and wherein clinical recovery, obvious effective rate are 46.6%; Control drug Herba Pileae Scriptae Tabellae total effective rate is 80%, and wherein clinical recovery, obvious effective rate are 40%; Checking is the result show, the precious curative effect of throat is preferable.Chronic pharyngitis patient's majority has symptoms such as dry pharynx, pharyngeal discomfort throughout the year, and is outstanding to eliminating the above-mentioned symptom curative effect because the precious secretion replenishing and throat moistening effect of throat is strong, and the health-care effect of moist throat is arranged.Do not see the heart, liver, kidney, hemopoietic system toxic side effect around taking medicine, non-stimulated to gastrointestinal tract.
Four, conclusion
Acute and chronic pharyngitis (anxious, chronic throat obstruction, chronic pharyngitis) is ear, nose, larynx section commonly encountered diseases, its sickness rate height.Use antibiotic and antiviral treatment clinically, curative effect is not ideal, and it is bigger to take toxic and side effects for a long time; Especially to the treatment of the pharyngeal dry symptom of chronic pharyngitis patient, in existing Chinese patent medicine, be difficult to find ideal medicine.Fructus Phyllanthi in the throat treasured side is commonly called as " Fructus Canarii albi " and commonly uses for our province is among the people in the Chinese medicine of treatment throat illness at our province, be equipped with Chinese medicines such as Rhizoma Belamcandae, Rhizoma Polygoni Cuspidati, it promotes the production of body fluid, and to moisturize the relieving sore throat and diminishing swelling effect very outstanding, by to clinical 45 routine acute pharyngitises (acute inflammation of the throat), determined curative effect is observed in the treatment of 15 routine chronic pharyngitiss (chronic throat obstruction, chronic pharyngitis), behind the medicine inlet, the promotion salivation is promptly arranged, alleviates dry laryngopharynx, symptom such as scorching hot rapidly, this be many similar medicines can't be obtained; Its anti-inflammatory analgetic effect also clearly has no side effect to the heart, liver, kidney, lung, hemopoietic system, and gastrointestinal tract is had no adverse reaction, and treatment acute/chronic pharyngitis (anxious, chronic throat obstruction, chronic pharyngitis) effective percentage reaches 98%.Therefore, evident in efficacy, safe in utilization, be worth in clinical treatment, promoting the use of.
Claims (3)
1, a kind of sore-throat relieving lozenge medicine for the treatment of the pharyngitis disease, it is characterized in that: it is mainly made by Fructus Phyllanthi, Rhizoma Belamcandae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae four Chinese medicine thing, and each herbal medicine is respectively by weight ratio: 150～310 parts of Fructus Phyllanthis, 18～22 parts of Rhizoma Belamcandae, 18～22 parts of Rhizoma Polygoni Cuspidati, 9～11 parts in Radix Glycyrrhizae.
2, the sore-throat relieving lozenge medicine of treatment pharyngitis disease according to claim 1, it is characterized in that: each herbal medicine proportioning by weight is: 280 parts of Fructus Phyllanthis, 20 parts of Rhizoma Belamcandae, 20 parts of Rhizoma Polygoni Cuspidati, 10 parts in Radix Glycyrrhizae.
3, a kind of method for preparing the sore-throat relieving lozenge medicine of the described treatment pharyngitis of claim 1 disease, it is characterized in that: the gross weight by Fructus Phyllanthi, Rhizoma Belamcandae, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae four Chinese medicine thing adds 6 times of water gagings, decoct twice, each 2 hours, filter, merging filtrate left standstill 24 hours, get supernatant, it is concentrated into that relative density surveys under 20 ℃ of temperature be 1.25～1.35; Get Mentholum, sucrose, serge blue, four kinds of raw materials of lemon yellow then as adjuvant; each adjuvant proportioning by weight is: 1.2～1.8 parts of Mentholums, 450～550 parts of sucrose, 0.01～0.03 part of serge blue, 0.08～0.12 part of lemon yellow; cane sugar powder is broken into fine powder; cross 60 mesh sieves; cane sugar powder, serge blue, lemon yellow are added in the extractum; mixing; make granule; and it is dry under 80 ℃ of temperature; with Mentholum with dissolve with ethanol after with the granule mixing, and get product through granulate, after being pressed into tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 200410022015 CN1233408C (en) | 2004-03-11 | 2004-03-11 | Tablet medicine for treating pharyngolaryngitis and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410022015 CN1233408C (en) | 2004-03-11 | 2004-03-11 | Tablet medicine for treating pharyngolaryngitis and its preparation method |
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| CN1233408C true CN1233408C (en) | 2005-12-28 |
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| CN102406031B (en) * | 2011-12-01 | 2013-01-16 | 广州白云山潘高寿药业股份有限公司 | Throat-smoothing candy containing natural extractives |
| CN103239572A (en) * | 2013-04-26 | 2013-08-14 | 湖南中医药大学 | Preparation for treating damp-heat type pharyngitis and preparation process thereof |
| CN106214860A (en) * | 2016-08-22 | 2016-12-14 | 陕西省中医药研究院汉唐制药有限公司 | For Chinese medicine composition treating acute/chronic pharyngitis and its preparation method and application |
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