Background technology
Inflammation of upper respiratory tract can be divided into infectious and allergia two big classes (latter belongs to pathergy), but the two site of pathological change is all at nose, pharynx, larynx, and their direct and trachea, lungs link, and can cause acute and chronic cough so their are fallen ill.Particularly chronic cough cough only, the apasm of coughing of acute attack repeatedly, more clinically see more, the length of the course of disease can surpass several months or several years, and often with nasal obstruction, sneeze, watery nasal discharge, laryngopharynx swelling and pain, scratchy, foreign body sensation etc., has not only made us being difficult to stand but also the symptom of aggravation cough more.The patient of quite a few also can be developed into asthma, has had a strong impact on people's physical and mental health, quality of life and social activity etc.Along with the pollution of environment, pollen is aerial to be increased in recent years, and the prolongation of the abundant and time of people's life content, no matter is infectious or the sickness rate of allergic nose, pharynx, laryngopathy all increases day by day.Show that only allergic rhinitis are one, perplexed with regard to the people that make the whole world 10~25% in the final report according to WHO one action in 2002 meeting, have the asthma patient of sniffle then to surpass 80% more than.As seen above-mentioned disease has become the whole nation even global commonly encountered diseases, frequently-occurring disease.Treat these diseases at present clinically and often use antibiotics, ephedrine, antihistaminic, even Drug therapy such as glucocorticoid, but that the general treatment phase imitates is long, and it is slower to produce effects, the medical expense height, therefore developing the definite medicine of novel therapeutic effect has great clinical value and social value.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of cough caused by inflammation of upper respiratory tract, this medicine has cough-relieving, antiinflammatory, dredges effects such as clearing the nasal passage, antiallergic and antipruritic, elimination foreign body sensation in the throat.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to the cough mechanism, at first use dialectical the executing of the traditional Chinese medical science to control, from motherland medicine treasure-house, select have cough-relieving, wet one's whistle, convergence, sensible, antipruritic, the classical Chinese medicine of controlling nasal sinusitis, again with reference to of the research of modern Chinese medicine pharmacology to the Chinese medicine active chemical, filter out in the selected classical Chinese medicine and not only meet differential diagnosis in tcm and execute and control but also meet the medicine that modern pharmacology requires, reasonable compositing formula component, repeatedly practise research clinical again, draw the optimum formula component at last.
Medicine of the present invention is made (consumption is a weight portion) by following component:
Flos Magnoliae 5~60, Radix Glycyrrhizae 6~20, Fructus Xanthii 5~25.
The optimum ratio (weight portion) that system is joined medicine of the present invention is:
Flos Magnoliae 10~40, Radix Glycyrrhizae 8~15, Fructus Xanthii 6~20.
The best proportioning (weight portion) of preparation medicine of the present invention is:
Flos Magnoliae 15, Radix Glycyrrhizae 8, Fructus Xanthii 8.
Medicine of the present invention production technology is routinely made said dosage form on the various pharmaceuticss, as liquor, unguentum, tablet, granule or capsule etc.
An important feature of medicine of the present invention is to have powerful relieving cough and diminishing inflammation and convergence itching-relieving action, and strong because of restraining antipruritic power, sensible power is big, thus to allergic rhinitis, sinusitis, nasopharyngitis and pharyngolaryngitis also have distinguished curative effect.Medicinal liquid can directly enter from mouth, nose, and by mucosa absorption, minute begin to work about 30 seconds to one.Nasal obstruction is by seeing mediation, just feels BITONG after 3-5 minute, and edema of throat disappears very soon.Viscosity or purulent secretion in nose, pharynx, the larynx are constantly discharged, and whole upper respiratory tract becomes comfortable, and hoarseness is also by getting better commentaries on classics.
Second characteristic of medicine of the present invention are that tangible itching-relieving action is arranged, and eliminate foreign body sensation in the throat rapidly.After the medication 3-5 minute, the patient was by feeling the obstruction sense of the scratchy and foreign body sensation of throat or sticking expectorant by disappearing, and cough also just relaxes thereupon, is reduced to disappearance.
The 3rd characteristics of medicine of the present invention are not only rapid-action, and keep drug effect and reach 8-12 hour, are used for stuffy nose relieving (treatment nasal obstruction) and put effect without male offspring, see Table 1.
The effect of table 1 stuffy nose relieving relatively
| Case (n) | Onset time | Hold time | After put effect |
With medicine group of the present invention | 20 | 30 seconds ± 2 | More than 8 hours | Do not have |
With 1% ephedrine group | 20 | 25 seconds ± 2 | Below 4 hours | Have |
The 4th characteristics of medicine of the present invention are the curative effect height, and according to clinical 200 routine patient observed results, the clinical total effective rate in two week backs reaches 98.5%, sees Table 2.
Table 2 invention medication is imitated and is observed (n=200)
| The stuffy nose relieving clearing throat | Clinic control | Produce effects | Take a turn for the better | Invalid | Total effective rate |
Onset in-3 minutes in 30 seconds | 100% | | | | | |
Treat the curative effect in two weeks | | 86% | 12.5% | 1% | 0 | 98.5% |
Clinical drug of the present invention uses the result to show to have following advantage:
(1) raw material of choice of drug of the present invention is classical Chinese medicine, and each component meets the pharmaceutical control law regulation.Utilize the disease curative effects such as cough due to the comprehensive function treatment inflammation of upper respiratory tract (comprising infectivity and allergia) of the medicine of respectively distinguishing the flavor of conclusive.Adding preservative agent is not nontoxic to human body.
(2) medicine of the present invention is the scientific achievement that Chinese and western medicine organically combines, and prescription is simple, and is easy to use, rapid-action, and curative effect is conclusive, and a medicine multiple efficacies, can reduce patient's types of medicines, saves medical expenses.
(3) during the anti-asthmatic coupling of medicine of the present invention and doctor trained in Western medicine, can alleviate or reduce the outbreak of cough with asthma, accelerate the alleviation of asthma and stable.
(4) the invention medicine can be made various dosage forms with common process, and is easy to use, meets the state food health legislation, both can use separately, also can with other in, Western medicine unites use, can reduce the consumption of Western medicine when share with Western medicine, shorten treatment time, save medical fee.
The specific embodiment
Embodiment 1
The present invention treats the medicine of cough caused by inflammation of upper respiratory tract and is made by the following weight Chinese medicinal raw materials:
Flos Magnoliae 10, Radix Glycyrrhizae 15, Fructus Xanthii 6.
Embodiment 2
The present invention treats the medicine of cough caused by inflammation of upper respiratory tract and is made by the following weight Chinese medicinal raw materials:
Flos Magnoliae 30, Radix Glycyrrhizae 8, Fructus Xanthii 15.
Embodiment 3
The present invention treats the medicine of cough caused by inflammation of upper respiratory tract and is made by the following weight Chinese medicinal raw materials:
Flos Magnoliae 35, Radix Glycyrrhizae 12, Fructus Xanthii 20.
Embodiment 4
The present invention treats the medicine of cough caused by inflammation of upper respiratory tract and is made by the following weight Chinese medicinal raw materials:
Flos Magnoliae 50, Radix Glycyrrhizae 15, Fructus Xanthii 8.
Embodiment 5
The present invention treats the medicine of cough caused by inflammation of upper respiratory tract and is made by the following weight Chinese medicinal raw materials:
Flos Magnoliae 15, Radix Glycyrrhizae 8, Fructus Xanthii 8.
The above embodiment can make said dosage form on the various pharmaceuticss by the Chinese medicine conventional production process, as liquor, unguentum, tablet, granule or capsule etc.