CN1111051C - Medicine for treating cough and asthma - Google Patents
Medicine for treating cough and asthma Download PDFInfo
- Publication number
- CN1111051C CN1111051C CN00131009A CN00131009A CN1111051C CN 1111051 C CN1111051 C CN 1111051C CN 00131009 A CN00131009 A CN 00131009A CN 00131009 A CN00131009 A CN 00131009A CN 1111051 C CN1111051 C CN 1111051C
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- medicine
- radix
- cough
- asthma
- present
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- Expired - Lifetime
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- 239000003814 drug Substances 0.000 title claims abstract description 61
- 206010011224 Cough Diseases 0.000 title claims abstract description 40
- 208000006673 asthma Diseases 0.000 title claims abstract description 30
- 229940079593 drug Drugs 0.000 title description 7
- 239000000843 powder Substances 0.000 claims abstract description 13
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 12
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 241000628997 Flos Species 0.000 claims description 11
- 241000202807 Glycyrrhiza Species 0.000 claims description 11
- 241000237636 Pheretima Species 0.000 claims description 11
- 241000207929 Scutellaria Species 0.000 claims description 11
- 210000000582 semen Anatomy 0.000 claims description 11
- 239000002552 dosage form Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 6
- 208000026435 phlegm Diseases 0.000 abstract description 6
- 230000009257 reactivity Effects 0.000 abstract description 4
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 230000008030 elimination Effects 0.000 abstract description 2
- 238000003379 elimination reaction Methods 0.000 abstract description 2
- 230000002787 reinforcement Effects 0.000 abstract description 2
- 210000002345 respiratory system Anatomy 0.000 abstract description 2
- 241000050051 Chelone glabra Species 0.000 abstract 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 241000218378 Magnolia Species 0.000 abstract 1
- 241000361919 Metaphire sieboldi Species 0.000 abstract 1
- 235000006751 Platycodon Nutrition 0.000 abstract 1
- 244000274050 Platycodon grandiflorum Species 0.000 abstract 1
- 244000018633 Prunus armeniaca Species 0.000 abstract 1
- 235000009827 Prunus armeniaca Nutrition 0.000 abstract 1
- 230000002301 combined effect Effects 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 229930189914 platycodon Natural products 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 11
- 206010036790 Productive cough Diseases 0.000 description 6
- 230000001684 chronic effect Effects 0.000 description 5
- 239000000812 cholinergic antagonist Substances 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000036428 airway hyperreactivity Effects 0.000 description 3
- 208000037976 chronic inflammation Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 206010025482 malaise Diseases 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000000414 obstructive effect Effects 0.000 description 3
- 230000002048 spasmolytic effect Effects 0.000 description 3
- QNVKOSLOVOTXKF-UHFFFAOYSA-N 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;hydron;chloride Chemical compound Cl.NC1=C(Br)C=C(Br)C=C1CNC1CCC(O)CC1 QNVKOSLOVOTXKF-UHFFFAOYSA-N 0.000 description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 2
- 229960000985 ambroxol hydrochloride Drugs 0.000 description 2
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 description 2
- 229960003556 aminophylline Drugs 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 2
- 239000003246 corticosteroid Substances 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000009325 pulmonary function Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 206010010970 Cor pulmonale chronic Diseases 0.000 description 1
- 206010014561 Emphysema Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 210000005091 airway smooth muscle Anatomy 0.000 description 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 208000026636 chronic pulmonary heart disease Diseases 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002650 habitual effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229960002052 salbutamol Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses medicine for treating cough and asthma, which is in the form of various preparations of Chinese patent medicine prepared from earthworm, clam shell powder, northern apricot, prepared herba ephedrae, liquoric root, platycodon root, magnolia flower, baical skullcap root, epimedium herb and panax notoginseng powder as raw material by proportions according to different characteristics of each kind of the traditional Chinese medicine. Clinical application shows that the present invention has combined effects on reinforcement and elimination for relieving inflammation, dissipating phlegm, relieving cough and asthma, reducing respiratory tract reactivity and enhancing constitution.
Description
The present invention relates to a kind of medicine for the treatment of cough and asthma, being specifically related to a kind of is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.
Cough, to cough up phlegm be one of modal symptom clinically.Except flu and acute and chronic inflammation of upper respiratory tract etc., chronic bronchitis and chronic obstructive disease of lung (COPD) also are one of commonly encountered diseases.According in China the north and 102230 adults' in middle part Epidemiological study show that only the sickness rate of COPD has reached 3%, and 30669 people are promptly arranged, these diseases have seriously influenced people's health.Treat these diseases, cough-relieving, expectoration are basic and important means.At present be divided into " cough medicine " and " expectorant " two classes in order to the medicine of treatment cough-relieving expectoration clinically, be respectively applied for and treat dry cough and sputum secretion increasing and cause on the different symptom of two classes of cough.But this two classes medicine particularly is that the asthma (being conceal type asthma) and the various cough that causes with airway hyperreactivity of cardinal symptom is of no curative effect with the cough to the cough of asthma attack phase.They must adopt trachea spasmolytic Drug therapy at present, and it will add with corticosteroid (being corticoid) medicine and could must imitate.As asthma, China's five metropolitan data show that 13～14 years old student's sickness rate is 3～5%, and adult's prevalence is 1% approximately.Current data more shows, the sickness rate of developed country is higher than developing country, even shown that the good more regional asthma prevalence of sanitary condition is high more, and therefore develop novelly, determined curative effect and significant cough-relieving, breathe heavily medicine and have great clinical value and social value.
The object of the present invention is to provide a kind of antiinflammatory expectoration that has, relieving cough and asthma reduces airway reactivity, the cough and asthma healing potion of health invigorating effect.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to cough and asthma mechanism, at first use dialectical the executing of the traditional Chinese medical science to control, from storehouse, motherland medicine chamber, select to take out and have relieving cough and asthma, pleasant expectoration, the tonifying the lung the kidney invigorating, the classical Chinese medicine of strengthening body, and, rescreen in the classical Chinese medicine that is selected and select the modern Chinese medicine pharmacology and also confirm that it has cough-relieving, relievings asthma with reference to the achievement of modern Chinese medicine pharmacological research, antiinflammatory, reduce phlegm antiallergic, the reaction of sending down the abnormal ascending QI road, the Chinese medicine of strengthening body, and further work out the most rational recipe ingredient.Medicine of the present invention is to make (consumption is a weight portion) by following component:
Pheretima 10～25 Pulvis concha Mactrae 10～35 Semen Armeniacae Amarums 5～15 Herba Ephedrae (processed) 5～12 Radix Glycyrrhizaes 1～6
Radix Platycodonis 5～20 Flos Magnoliae 5～30 Radix Scutellariaes 5～20 Herba Epimedii 6～30 Radix Notoginseng powder 3～4
Formula optimization proportioning (weight portion) scope that system is joined medicine of the present invention is:
Pheretima 10～20 Pulvis concha Mactrae 15～25 Semen Armeniacae Amarums 8～10 Herba Ephedrae (processed) 5～9 Radix Glycyrrhizaes 1～4
Radix Platycodonis 5～15 Flos Magnoliae 8～15 Radix Scutellariaes 6～15 Herba Epimedii 6～16 Radix Notoginseng powder 0.3～2
The best proportioning (weight portion) of medicine of the present invention is:
Pheretima 15 Pulvis concha Mactrae 18 Semen Armeniacae Amarums 8 Herba Ephedrae (processed) 8 Radix Glycyrrhizaes 4
Radix Platycodonis 8 Flos Magnoliae 10 Radix Scutellariaes 6 Herba Epimedii 10 Radix Notoginseng powder 1.2
Medicine of the present invention production technology is routinely made said dosage form on the various pharmaceuticss, as liquor, unguentum, tablet or capsule etc.
An important feature of medicine of the present invention is not only to contain the suppressing panting calming medicine that generally can make the air flue spasmolytic in the medicament, but also can reduce airway hyperreactivity, this is the asthma of cardinal symptom for the asthma that is caused airway hyperreactivity to produce by the air flue chronic inflammatory disease or with the cough, other cough-relieving expectoration medicines are of no curative effect, and this medicament then demonstrates its distinctive effect.In a clinical research, show, the 14 routine cough type asthmatic patients that adopt conventional trachea spasmolytic medicine such as aminophylline, salbutamol and aminophylline etc. and do not adopt corticosteroid medication to treat, cough disappearance person in treatment back has 9 examples, and the brinchial provocation test person of turning out cloudy has only 3 examples, PD
20-FEV
14 examples that raise, effective percentage has 50% (7/14), but in taking the 14 routine patients in addition of medicament of the present invention, the cough transference cure is totally 13 examples, and the brinchial provocation test person of turning out cloudy has 10 examples, PD
20-FEV
1Rising person's 3 examples, only 1 example transfers typical asthma to, and effective percentage reaches 93% (13/14), and relatively there were significant differences (P＜0.05) to show between two groups effective percentage.
Another important feature of medicine of the present invention be have significantly eliminate the phlegm, the curative effect of cough-relieving, but also because of containing airway smooth muscle spasmolytic and treatment air flue chronic inflammatory disease, reduce the power of airway reactivity, thereby excellent curative is arranged the patient of chronic gas inflammation of treatment, chronic obstructive lung illness.In another clinical research, show, light chronic the gas inflammation of moderate of 100 examples, obstructive emphysema, the patient of chronic pulmonary heart disease, when adopting suitable antibacterial drug therapy, wherein, 50 routine patients of matched group do the expelling phlegm for arresting cough treatment for adopting conventional Ambroxol Hydrochloride, 50 examples then use medicament of the present invention to make test group in addition, their clinical total effective rate is respectively 45/50 example (90%) and 48/50 example (96%), relatively do not have marked difference between two groups, need then obviously be better than matched group with natural law but the latter is medicament group of the present invention treatment back clinic control number and onset time and clinic control.The improvement of treatment back pulmonary function, medicament group of the present invention is good than matched group obviously also.The expelling phlegm for arresting cough effect that medicine of the present invention is described has the Ambroxol Hydrochloride of good curative effect improving pulmonary function than clinical proof so far, even more superior aspect shortening the course of treatment.Following table I, II, III have shown two groups of patients' clinical therapeutic efficacy:
Two groups of case curative effects of Table I comparative example (%)
Clinic control (%) produce effects (%) improvement (%) invalid (%) total effective rate test group 38 (76) 10 (20) 2 (4) 0 (0) 48 (96) matched groups 21 (42) 25 (50) 5 (10) 0 (0) 45 (90) P＞0.05
Onset time relatively after two groups of patients of Table II took medicine
Example number onset time (my god) the clinic control time (my god) test group 50 2.36 ± 0.38 6.38 ± 2.46 matched group 50 3.12 ± 2.35 7.26 ± 3.13P＜0.01＜0.01
Two groups of patient FEV of Table III
1Comparison before and after the treatment
(liter/second) treatment back (liter/second) test group 50 2.06 2.98 matched groups 50 2.43 2.72P＜0.01 before the treatment of example number
Clinical drug of the present invention uses the result to show to have following advantage:
(1) raw material of choice of drug of the present invention is classical Chinese medicine, and each component meets the pharmaceutical control law regulation.Utilize the comprehensive function treatment cough and asthma of the medicine of respectively distinguishing the flavor of, adding preservative agent is not nontoxic to human body, and it has the effect of reinforcement and elimination in combination, and the chronic can take for a long time, makes it to keep airway patency and health invigorating, reduces airway reactivity.
(2) medicine of the present invention is the scientific achievement that Chinese and western medicine organically combines, and a kind of medicine multiple efficacies can reduce patient's types of medicines, saves medical expenses.
(3) medicine of the present invention can be made various dosage forms with habitual common process, and is easy to use, meets the state food health legislation, both can use separately, also can unite use, when uniting use with Western medicine with other Chinese medicine and western medicine, the consumption that can reduce Western medicine also can promote rehabilitation, shortens treatment time.
Embodiment 1
The present invention treats the medicine of cough and asthma, is made by the following weight Chinese medicinal raw materials:
Pheretima 10 Pulvis concha Mactrae 15 Semen Armeniacae Amarums 6 Herba Ephedrae (processed) 6 Radix Glycyrrhizaes 1
Radix Platycodonis 5 Flos Magnoliae 10 Radix Scutellariaes 6 Herba Epimedii 8 Radix Notoginseng powder 0.5
Embodiment 2
The present invention treats the medicine of cough and asthma, is made by the following weight Chinese medicinal raw materials:
Pheretima 15 Pulvis concha Mactrae 20 Semen Armeniacae Amarums 8 Herba Ephedrae (processed) 8 Radix Glycyrrhizaes 2
Radix Platycodonis 8 Flos Magnoliae 15 Radix Scutellariaes 10 Herba Epimedii 15 Radix Notoginseng powder 1.5
Embodiment 3
The present invention treats the medicine of cough and asthma, is made by the following weight Chinese medicinal raw materials:
Pheretima 15 Pulvis concha Mactrae 18 Semen Armeniacae Amarums 8 Herba Ephedrae (processed) 8 Radix Glycyrrhizaes 4
Radix Platycodonis 8 Flos Magnoliae 10 Radix Scutellariaes 6 Herba Epimedii 10 Radix Notoginseng powder 1.2
Embodiment 4
The present invention treats the medicine of cough and asthma, is made by the following weight Chinese medicinal raw materials:
Pheretima 25 Pulvis concha Mactrae 30 Semen Armeniacae Amarums 13 Herba Ephedrae (processed) 10 Radix Glycyrrhizaes 3
Radix Platycodonis 20 Flos Magnoliae 25 Radix Scutellariaes 18 Herba Epimedii 25 Radix Notoginseng powder 3
Embodiment 5
The present invention treats the medicine of cough and asthma, is made by the following weight Chinese medicinal raw materials:
Pheretima 15 Pulvis concha Mactrae 20 Semen Armeniacae Amarums 10 Herba Ephedrae (processed) 8 Radix Glycyrrhizaes 2
Radix Platycodonis 10 Flos Magnoliae 10 Radix Scutellariaes 10 Herba Epimedii 10 Radix Notoginseng powder 1
The above embodiment production technology routinely makes said dosage form on the various pharmaceuticss, as liquor, unguentum, tablet or capsule etc.
Claims (5)
1, a kind of medicine for the treatment of cough and asthma is characterized in that it is the medicament of being made by the following weight proportion raw material:
Pheretima 10～25 Pulvis concha Mactrae 10～35 Semen Armeniacae Amarums 5～15 Herba Ephedrae (processed) 5～12 Radix Glycyrrhizaes 1～6
Radix Platycodonis 5～20 Flos Magnoliae 5～30 Radix Scutellariaes 5～20 Herba Epimedii 6～30 Radix Notoginseng powder 3～4
2, the medicine of treatment cough and asthma according to claim 1, wherein the weight proportion of each raw material is:
Pheretima 10～20 Pulvis concha Mactrae 15～25 Semen Armeniacae Amarums 8～10 Herba Ephedrae (processed) 5～9 Radix Glycyrrhizaes 1～4
Radix Platycodonis 5～15 Flos Magnoliae 8～15 Radix Scutellariaes 6～15 Herba Epimedii 6～16 Radix Notoginseng powder 0.3～2
3, the medicine of treatment cough and asthma according to claim 1, wherein the weight proportion of each raw material is:
Pheretima 15 Pulvis concha Mactrae 18 Semen Armeniacae Amarums 8 Herba Ephedrae (processed) 8 Radix Glycyrrhizaes 4
Radix Platycodonis 8 Flos Magnoliae 10 Radix Scutellariaes 6 Herba Epimedii 10 Radix Notoginseng powder 1.2
4,, it is characterized in that described medicament is a said dosage form on any pharmaceutics according to the medicine of claim 1,2 or 3 described treatment cough and asthmas.
5, the medicine of treatment cough and asthma according to claim 4 is characterized in that described medicament is liquor, unguentum, tablet or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00131009A CN1111051C (en) | 2000-12-27 | 2000-12-27 | Medicine for treating cough and asthma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00131009A CN1111051C (en) | 2000-12-27 | 2000-12-27 | Medicine for treating cough and asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1307881A CN1307881A (en) | 2001-08-15 |
| CN1111051C true CN1111051C (en) | 2003-06-11 |
Family
ID=4594427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN00131009A Expired - Lifetime CN1111051C (en) | 2000-12-27 | 2000-12-27 | Medicine for treating cough and asthma |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1111051C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1301120C (en) * | 2005-06-03 | 2007-02-21 | 林定增 | Medicine for treating breadth gasp, cough, asthma and phelgm |
| CN101391024B (en) * | 2008-07-25 | 2011-04-06 | 陈楚挺 | Traditional Chinese medicine product for treating emphysema, tracheitis, asthma and cough |
| CN104758345A (en) * | 2015-04-10 | 2015-07-08 | 韩彩敏 | Traditional Chinese medicine for treating emphysema |
-
2000
- 2000-12-27 CN CN00131009A patent/CN1111051C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1307881A (en) | 2001-08-15 |
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Owner name: LUO JINGHUI Free format text: FORMER OWNER: LIN DINGZENG Effective date: 20040407 |
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Effective date of registration: 20120814 Address after: 510623 Guangdong Province, Guangzhou Tianhe District Zhujiang New City, Golden Harvest Road No. 721 Sea View Park A-1202 Patentee after: Yu Jia Address before: 28, 1207 building, 195 Dongfeng West Road, 510180, Guangzhou Medical College, Guangdong, Guangzhou Patentee before: Xiao Zhenglun |
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