CN1533795A - Chinese medicine for treating digestive ulcerating sore and its preparation method - Google Patents
Chinese medicine for treating digestive ulcerating sore and its preparation method Download PDFInfo
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Abstract
A Chinese medicine for treating peptic ulcer is prepared from 13 Chinese-medicinal materials including Mantis egg-case, bletilla tube, Sichuan chinaberry, corydalis tuber, etc. Its advantages are high curative effect, quickly taking its effect, low recurrence rate, and no untoward effect.
Description
Affiliated technical field
The invention belongs to the preparing technical field of pharmaceuticals, relate to a kind of Chinese patent medicine preparation that is used for the treatment of peptic ulcer and preparation method thereof.
Background technology
Peptic ulcer is called " stomach, duodenal ulcer " again." primary disease is commonly encountered diseases, frequently-occurring disease, and total incidence accounts for 10%～12% of population, can betide any age, but is many with person between twenty and fifty, and the male is more than the women, and ratio between two is about 3: 1.If control is improper, can cause severe complications, as massive hemorrhage, gastric perforation, pyloric obstruction or canceration etc." (Chen Guiyan etc. " practical combination of Chinese and Western medicine diagnoses and treatment " Chinese Medicine science and technology publishing house, 1990; P437).
Modern medicine thinks that the pathology of peptic ulcer is comparatively complicated.In short, the formation of ulcer mainly is protection factor (mucous epithelium lipoprotein layer, mucosa albumin layer, the blood circulation of mucosa, mucomembranous epithelial cell secreting mucus and the HCO to stomach, duodenal mucosa
3 -Deng the mucosal barrier that forms) and due to the relation of damage factor (cigarette, wine, the some drugs stimulation, mucosa is by Helicobacter pylori infection etc. for the too high secretion of gastric acid-pepsin, eating cold and uncooked food excessively, irritable food such as hard, sour, peppery) lacks of proper care.When damage factor increase and/or the weakening of protection factor, can cause ulcer to take place.Doctor trained in Western medicine mainly contains the Therapeutic Method and the medicine of primary disease at present: antacid (as aluminium hydroxide, magnesium oxide, Magnesium Trisilicate, gastropine, veytalo tablet etc.), anticholinergic agent (as probanthine, atropine, Complex Belladonna etc.), bisfentidine (as first cyanogen rice croak, ranitidine, famotidine etc.), H
+-K
+Atpase inhibitor (as omeprazole), calcium channel blocker (as nifedipine, verapamil), gastric mucosal barrier protective agent (as metoclopramide, carbenoxolone, sucralfate etc.), eliminating pylorus therapy (as bismuth+antibiotics).Though Western medicine has short term effect preferably to primary disease at present, western medicine relapse rate height reaches 60%-80% in general 1 year.
Motherland's traditional medicine thinks that " peptic ulcer belongs to ' gastric abscess ', ' acid regurgitation ', ' noisy ' disease category, and the etiology and pathogenesis of primary disease mainly contains: feelings will stimulates, and irritability is lost and dredged, and perverse and unreasonable manner is violated stomach; Intemperance of taking food, burnt in impairing the spleen and stomach or the damp and hot heap soil or fertilizer over and around the roots knot, the stomach film is impaired; Overstrain, impairment of the spleen consumption gas, the stomach film is not given birth to.The sick position of primary disease is at stomach, and is the closest with liver spleen relation.At the pathogenesis conversion aspect, primary disease has by gas and blood, Sthenia is transforming into asthenia, the characteristics of injury of YANG due to overabundant cold, heat-transformation impairment of YIN.Clinical treatment is many based on dispersing the stagnated liver-QI for regulating the stomach (as the ulcer curing tablet that is good for the stomach, JINFO ZHITONG WAN, stomach-recovering capsule), warming middle-JIAO (as the cold of insufficiency type and stomachache electuary), yin nourishing stomach reinforcing (as yin deficiency and gastralgia electuary, YANGWEISHU electuary), the blood stasis dispelling methods such as (as stomach-recovering capsule), regulating cold and heat of invigorating blood circulation that are good for the stomach " (" traditional Chinese medical science gastroenterology " Chinese medicine science and technology publishing house such as Li Qian structure, 1993; P448).Though it is multiple that the etiology and pathogenesis of primary disease has, unsuccessful with feelings will, depression of liver-QI, it is main etiology and pathogenesis that perverse and unreasonable manner is violated stomach, sees with the stagnation of liver-QI and stomach-QI syndrome of blood stasis of holding concurrently clinically more.Be that the medicine of main effect has the ulcer curing tablet of being good for the stomach, JINFO ZHITONG WAN, stomach-recovering capsule, soothing liver-QI stomach function regulating oral liquid etc. with dispersing the stagnated liver-QI for regulating the stomach in recent years.According to interrelated data, the effective percentage of these medicines is all more than 90%, and wherein the curative effect of stomach-recovering capsule is better.Its weak point is so also arranged, as above-mentioned medicine in onset time, relieving gastric hyperacidity to alleviate stomachache effect, more the aspect is all not very good infections cycle etc., and the ulcer curing tablet that is good for the stomach also finds to have side effect such as impairment of YIN so that thirsty, dry stool in clinical use.
Summary of the invention
The object of the present invention is to provide the novel science of a kind of prescription, easy to prepare, curative effect is high, instant effect, relapse rate is low and the Chinese patent medicine of treatment peptic ulcer that human body is had no side effect.
Another object of the present invention is to provide the preparation method of this Chinese patent medicine.
The preparation scheme of medicine of the present invention comes from " radicallying reform " determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs thoughts such as " treating both the principal and secondary aspects of a disease " of motherland's medical science, and to be the inventor obtain according to clinical practice experience for many years and taking in concurrently to sum up to develop on the theoretical and experiment basis of a large amount of at all times medicine and pharmacology for it.Peptic ulcer is clinical to be seen because frequent seven emotions stimulate more, the angry stagnation of liver-QI and stomach-QI that causes of particularly the being worried syndrome of blood stasis of holding concurrently.Its etiology and pathogenesis is, the unsuccessful depression of liver-QI that causes of feelings will, and perverse and unreasonable manner is violated stomach, and qi-blood disharmony knot gathers in stomach, and is contrary in the meat reason, and the stomach film loses supports, and flesh and blood addles and bursts and be infections.Stagnation of liver-QI and stomach-QI is so see gastral cavilty distending pain, two side of body feeling of distension and oppression, irritated irritability; " pain is gone into network for a long time ", stomach network blood stasis is so see the gastral cavilty twinge; If the stasis of blood is decreased the stomach network, blood oozing from the body openings or subcuta neous tissue is outside network, and is in last visible hematemesis, following to the visible melena of intestinal with food with QI rising in reverse order.Stagnation of liver-QI and stomach-QI, stomach-QI being unable to descend normally is so see noisy, belch, poor appetite; Gastric qi is lost and is fallen, and QI rising in reverse order is seen acid regurgitation, feels sick, vomitted in last event.Stagnation of liver-QI should be dredged, stomach stagnate suitable and, the network stasis of blood should be led to, the stomach film is impaired routed and be that infections should be held back infections granulation promoting cuticula.So the assertive evidence rule of treatment should be dispersing the stagnated liver-QI for regulating the stomach, removing obstruction in the collateral to relieve pain is held back the infections cuticula, the antacid preventing or arresting vomiting.According to above-mentioned etiology and pathogenesis understanding, the raw material of Chinese medicine side of being prepared into that designer of the present invention suits the medicine to the illness drug effects more selected and concentrates and be easy to absorb for the human liver stomach, side's Chinese medicine is by comprising Endoconcha Sepiae (Os Sepiae), Pseudobulbus Bletillae (Rhizoma Bletillae) (loft in vain), Fructus Toosendan, Rhizoma Corydalis, Rhizoma Coptidis, Fructus Evodiae, Rhizoma Cyperi, Radix Et Rhizoma Nardostachyos, Radix Curcumae, Rhizoma Curcumae, Pericarpium Citri Reticulatae, Rhizoma Pinelliae, Endothelium Corneum Gigeriae Galli is formed at interior meter 13 herbal medicines, full side has dispersing the stagnated liver-QI for regulating the stomach, removing obstruction in the collateral to relieve pain, hold back the infections cuticula, the effect of antacid preventing or arresting vomiting, to peptic ulcer (active stage) because of the stagnation of liver-QI and stomach-QI stomachache that blood stasis causes of holding concurrently, pantothenic acid, vomiting, belch, poor appetite, the treatment aspect of bitter taste etc. has fabulous effect.
The weight proportion value that constitutes each raw material components of treatment digestive ulcer medicament of the present invention is:
Endoconcha Sepiae (parching to brown) 15～25; Pseudobulbus Bletillae (Rhizoma Bletillae) 5～15; Fructus Toosendan (vinegar system) 3～5;
Rhizoma Corydalis (vinegar system) 4～6; Rhizoma Coptidis 1～3; Fructus Evodiae 0.5～1.3;
Rhizoma Cyperi (vinegar system) 4～6; Radix Et Rhizoma Nardostachyos 2～4; Radix Curcumae (vinegar system) 4～6;
Rhizoma Curcumae 2～4; Pericarpium Citri Reticulatae 3～5; Rhizoma Pinelliae 3～6;
Endothelium Corneum Gigeriae Galli (parching to brown) 4～6.
The above-mentioned medicine material that is used for the treatment of peptic ulcer all meets " the regulation of relevant each kind of Chinese pharmacopoeia version in 2000.Side's Chinese medicine is reused Endoconcha Sepiae for monarch, loose strongly fragrant stomach function regulating, relieving gastric hyperacidity to alleviate stomachache, holds back the infections cuticula; Minister is with the diffusing strongly fragrant infections cuticula of holding back of Pseudobulbus Bletillae (Rhizoma Bletillae) principal drug assistance; With the Fructus Toosendan of Sichuan Chinaberry Powder, Rhizoma Corydalis pungent drugs can disperse and bitter drugs can descend with the pain relieving of principal drug assistance depressed liver-energy dispersing and QI regulating; Assistant with the soothing the liver sending down the abnormal ascending QI of Rhizoma Coptidis, Fructus Evodiae of Zuojin Wan with stomach function regulating, Rhizoma Cyperi, Radix Et Rhizoma Nardostachyos regulating QI to relieve pain, Radix Curcumae, the pain relieving of Rhizoma Curcumae disperse blood stasis and dredge collateral; Pericarpium Citri Reticulatae, Rhizoma Pinelliae stopping nausea and vomiting by lowering the adverse flow of QI, Endothelium Corneum Gigeriae Galli cooperate Radix Et Rhizoma Nardostachyos, Pericarpium Citri Reticulatae, the Rhizoma Pinelliae stomach function regulating that is good for the stomach to receive fortune to help.We monarch one, minister three, assistant nine, long memorial liver stomach function regulating, removing obstruction in the collateral to relieve pain, the merit of holding back infections cuticula, antacid preventing or arresting vomiting altogether.Peptic ulcer (active stage) there is fabulous effect because of hold concurrently stomachache that blood stasis causes, pantothenic acid, vomiting, belch, poor appetite, bitter taste etc. of stagnation of liver-QI and stomach-QI.After the clinic trial, have rapid-action (within the general week), antacid, relieving pain, heal the infections cycle short (generally in January), the characteristics that relapse rate is low, have no adverse reaction, and symptoms such as two side of body feeling of distension and oppression that syndrome of blood stasis showed, noisy, belch, poor appetite, nausea and vomiting, melena that the stagnation of liver-QI and stomach-QI of peptic ulcer disease held concurrently have significant improvement effect.
The above-mentioned medicine that is used for the treatment of peptic ulcer can be made said multiple dosage form on the pharmaceutics, as capsule, tablet, oral liquid or powder etc.
Above-mentioned materials of weight proportions is made the method for medicine capsule of the present invention or tablet, may further comprise the steps:
(1), get Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Endothelium Corneum Gigeriae Galli, Rhizoma Coptidis mixed powder and be broken into the above fine powder of 100 orders, standby;
(2), get Rhizoma Corydalis, the Rhizoma Pinelliae mixed powder is broken into coarse powder, with 60～80% ethanol is solvent, flooded 20～72 hours according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), speed percolation with every kilogram of medicine 2～4ml/min, collection percolate total amount is equivalent to 6～10 times of medication amount, and medicinal residues are standby;
(3), get the percolate that above-mentioned steps (2) obtains and reclaim ethanol, be concentrated into relative density and be the thick paste of 1.30～1.40 (60 ℃), standby;
(4), get in the prescription that the medicinal residues behind the Rhizoma Corydalis and Rhizoma Pinelliae percolation merge in all the other medicines and above-mentioned steps (2), add 10～14 times of amounts of water, soaked 1～5 hour, decoct distillation 2～5 hours, collect volatile oil and with the dehydrated alcohol diluted for use, the filtrate decocting liquid is the 1st extract; Medicinal residues decoct 1～2 time again, add 8～10 times of amounts of water at every turn, decoct 1～2 hour, filter, and merge each time decocting liquid, and being concentrated into relative density is the thick paste of 1.3-1.40 (60 ℃), is incubated standby;
(5), getting step (3) percolation gained thick paste joins in the thick paste of above-mentioned steps (4) gained, mixing, again with the fine powder mixing of four Chinese medicine things such as Endoconcha Sepiae, drying, be ground into 20 order left and right sides coarse grain, sieve is got wherein part fine powder, increases progressively mixing with whole granules again after absorbing above-mentioned volatile oil, and airtight moistening is more than 2 hours, the magnesium stearate fine powder that adds granule total amount 0.8～1.2%, mixing, encapsulated or tabletting promptly gets the capsule or the tablet of medicine of the present invention.
The specific embodiment
Embodiment 1
The medicament capsule that a kind of Department of Pharmacy for the treatment of peptic ulcer provided by the invention is made by the following weight proportion raw material:
Endoconcha Sepiae (parching to brown) 251g Pseudobulbus Bletillae (Rhizoma Bletillae) 101g Fructus Toosendan (vinegar system) 40g
Rhizoma Corydalis (vinegar system) 50g Rhizoma Coptidis 20g Fructus Evodiae 10g Rhizoma Cyperi (vinegar system) 50g
Radix Et Rhizoma Nardostachyos 30g Radix Curcumae (vinegar system) 50g Rhizoma Curcumae 30g Pericarpium Citri Reticulatae 40g
Rhizoma Pinelliae 60g Endothelium Corneum Gigeriae Galli (parching to brown) 50g
Above-mentioned materials of weight proportions is made the capsular method of the present invention is: above 13 flavors, and get Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Endothelium Corneum Gigeriae Galli, Rhizoma Coptidis mixed powder and be broken into 120 order fine powders, standby; Rhizoma Corydalis, Rhizoma Pinelliae mixed powder are broken into coarse powder, 65% ethanol is solvent, flooded 50 hours according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), speed percolation with every kilogram of medicine 2ml/min, the collection liquid total amount of filtering is equivalent to 10 times of medication amount, reclaim ethanol, when being concentrated into relative density and being the thick paste of 1.30 (60 ℃), standby; Other gets, and the medicinal residues behind all the other medicines and Rhizoma Corydalis and Rhizoma Pinelliae percolation merge in the prescription, decoct with water 2 times, add 14 times of amounts of water first, soak 2 hours, decoct distillation 3 hours, collect volatile oil and with the dehydrated alcohol diluted for use, the filtrate decocting liquid is the extract first time; For the second time add 10 times of amounts of water, decocted 1 hour, filter the back and merge twice decocting liquid, when being concentrated into relative density and being 1.40 (60 ℃) while hot with above-mentioned percolation gained thick paste mixing, again with the fine powder mixing of four Chinese medicine things such as Endoconcha Sepiae, drying, be ground into 20 order left and right sides coarse grain, sieve is got wherein part fine powder, increases progressively mixing with whole granules again, airtight moistening 6 hours after absorbing above-mentioned volatile oil, the magnesium stearate fine powder that adds granule total amount 1%, mixing, encapsulated, promptly make capsule of the present invention.
Embodiment 2
The sheet type medicament that the Department of Pharmacy of another kind of treatment peptic ulcer provided by the invention is made by the following weight proportion raw material:
Endoconcha Sepiae (parching to brown) 231g Pseudobulbus Bletillae (Rhizoma Bletillae) 110g Fructus Toosendan (vinegar system) 50g
Rhizoma Corydalis (vinegar system) 50g Rhizoma Coptidis 25g Fructus Evodiae 13g Rhizoma Cyperi (vinegar system) 50g
Radix Et Rhizoma Nardostachyos 30g Radix Curcumae (vinegar system) 50g Rhizoma Curcumae 33g Pericarpium Citri Reticulatae 44g
Rhizoma Pinelliae 57g Endothelium Corneum Gigeriae Galli (parching to brown) 60g
The sheet agent method of above-mentioned materials of weight proportions being made medicine of the present invention is: above 13 flavors, and get Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Endothelium Corneum Gigeriae Galli, Rhizoma Coptidis mixed powder and be broken into 120 order fine powders, standby; Get Rhizoma Corydalis, the Rhizoma Pinelliae mixed powder is broken into 20 order left and right sides coarse powder, 75% ethanol is solvent, flooded 70 hours according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), speed percolation with every kilogram of medicine 3ml/min, the collection liquid total amount of filtering is equivalent to 8 times of medication amount, reclaim ethanol, when being concentrated into relative density and being the thick paste of 1.40 (60 ℃), standby; Other gets, and the medicinal residues behind all the other medicines and Rhizoma Corydalis and Rhizoma Pinelliae percolation merge in the prescription, decoct with water 3 times, add 12 times of amounts of water first, soaked 2 hours, decoction volatile matter distillation oil 4 hours is collected volatile oil and with the dehydrated alcohol diluted for use, the filtrate decocting liquid is the extract first time; Second and third time respectively adds 8 times of amounts of water, decocted 1.5 hours, filter, merge 3 times decocting liquid, when being concentrated into relative density and being 1.35 (60 ℃) while hot with above-mentioned percolation gained thick paste mixing, again with the fine powder mixing of four Chinese medicine things such as Endoconcha Sepiae, 60 ℃ of dryings, be ground into 20 order left and right sides coarse grain, sieve is got wherein part fine powder, increases progressively mixing with whole granules again after absorbing above-mentioned volatile oil, and airtight moistening is more than 4 hours, the magnesium stearate fine powder that adds granule total amount 1.2%, mixing, tabletting promptly makes the tablet of medicine of the present invention.
The present invention is to provide a kind of natural drug for the treatment of peptic ulcer, for proving its therapeutic effect and safety, the inventor uses the capsule for preparing by the method that provides in the foregoing description 1 to carry out toxicity, pharmacodynamics test and clinical trial, and result of study is as follows:
[toxicology test conclusion]
The animal acute toxicity test of capsule of the present invention being done through Xian Medical Univ's clinical pharmacology institute shows, irritate stomach with the aqueous suspensions of capsule medicated powder of the present invention and give mice, maximum tolerated dose that must this medicine is 21.96g/kg (in crude drug 35.4g/kg), is equivalent to 295.2 times of Coming-of-Age Day dose.The LD of this medicine
50Do not measure.
Three months long term toxicity test results that capsule of the present invention done through Xian Medical Univ's clinical pharmacology institute show, capsule of the present invention heavy dose of (26.9 times, 53.8 times, 107.5 multiple doses of adult's consumption) is given rat continuous irrigation stomach 90 days, each dosage group rat generally in order, appetite and body weight etc. are all normal, hematology, blood parameters, detecting ECG result are normal, organ coefficient is also no abnormal, and system dissects and histopathological examination does not all have the pathologic change.This medicine is described at the rat long term toxicity test, does not see the overt toxicity reaction, also do not have the retardance toxic reaction.The animal safety consumption is 8g/kg, in crude drug 12.9g/kg, is equivalent to 107.5 times of Coming-of-Age Day consumption.
[Pharmacodynamic test of active extract conclusion]
The Pharmacodynamic test of active extract of capsule of the present invention being done through Xian Medical Univ's clinical pharmacology institute shows, this medical instrument have the water logging of obvious suppression mice stress type ulcer, the formation of reserpine type ulcer, rat pyloric ligation ulcers ulcer, rat acetic acid method ulcer is also had tangible promotion healing effect.Gastric analysis result shows that this medicine can suppress gastric secretion, reduces free acidity, total acidity and total acid output, and heavy dose also can reduce white enzymatic activity of stomach dawn.This medicine also has significant analgesia role, can obviously reduce the mouse writhing reaction times that chemical stimulation causes, but to the activity and the spasm unrestraint effect of rabbit intestine in vitro.Helicobacter pylori to In vitro culture has certain bacteriostasis, and minimal inhibitory concentration is 20%.
[clinical trial conclusion]
According to Ministry of Public Health bureau of drug policy ﹠ administration (1999) ZL-19 certification, by Xiyuan Hospital, Chinese Medicine Academy of China, first hospital of Xi'an Communications University, No.2 Hospital of Xi'an Jiaotong Univ., Traditional Chinese Medicine Research Institute, Shanxi Province Affiliated Hospital May in November, 1999 to calendar year 2001, adopt the method for randomized, double-blind treatment contrast and open treatment, 421 routine clinical trials have been carried out in the effect and the safety of capsule of the present invention (contrast medicine stomach-recovering capsule) treatment gastric ulcer, duodenal ulcer.Wherein, gastric ulcer 211 examples (double-blind treatment group 120 examples, double blind control group 60 examples, open treatment group 31 examples), the result shows, gastroscopy effect: treatment group cure-remarkable-effectiveness rate 59.17%, total effective rate 84.17%; Matched group cure-remarkable-effectiveness rate 46.67%, total effective rate 63.33% compares there was no significant difference (P＞0.05) between group; Open group cure-remarkable-effectiveness rate is 64.52%, and total effective rate is 83.87%.Tcm syndrome curative effect: treatment group cure-remarkable-effectiveness rate 40.00%, total effective rate 87.50%; Matched group cure-remarkable-effectiveness rate 46.67%, total effective rate 78.33% compares there was no significant difference (P＞0.05) between group; Open group cure-remarkable-effectiveness rate 61.29%, total effective rate 93.55%.Duodenal ulcer 210 examples (double-blind treatment group 120 examples, double blind control group 60 examples, open treatment group 30 examples), the result shows, gastroscopy effect: treatment group cure-remarkable-effectiveness rate 55.83%, total effective rate 77.50%; Matched group cure-remarkable-effectiveness rate 51.67%, total effective rate 73.33% compares there was no significant difference (P＞0.05) between group; Open group cure-remarkable-effectiveness rate 50.00%, total effective rate 70.00%.Tcm syndrome curative effect: treatment group cure-remarkable-effectiveness rate 63.33%, total effective rate 87.50%; Matched group cure-remarkable-effectiveness rate 50.00%, total effective rate 85.00% compares there was no significant difference (P＞0.05) between group; Open group cure-remarkable-effectiveness rate 63.33%, total effective rate 86.67%.
Result of the test shows that capsule of the present invention has the helicobacter pylori effect of killing preferably (P＜0.01); To doing well,improvings such as the gastric abscess that peptic ulcer showed, noisy pantothenic acid, belch singultuss obviously and be better than stomach-recovering capsule (P＜0.01); To gastric abscess average onset time be 12.67 ± 7.06 days, and can obviously improve the gastric abscess outbreak rhythm and pace of moving things.
Result of the test shows, all are tried blood before and after patient's medication, urine, just routine and the heart (ECG), liver (ALT), kidney (BUN, Cr) Function detection, do not find because of drug-induced toxic and side effects.Also do not see obvious adverse reaction.
In sum, capsule of the present invention is held concurrently to stagnation of liver-QI and stomach-QI, and syndrome of blood stasis gastric ulcer, duodenal ulcer have definitely, significant curative effect, and clinical safe in utilization.
Claims (3)
1, a kind of medicine for the treatment of peptic ulcer is characterized in that it is the medicine of the said dosage form of pharmaceutics made by the following weight proportion raw material:
Endoconcha Sepiae 15～25; Pseudobulbus Bletillae (Rhizoma Bletillae) 5～15; Fructus Toosendan 3～5;
Rhizoma Corydalis 4～6; Rhizoma Coptidis 1～3; Fructus Evodiae 0.5～1.3;
Rhizoma Cyperi 4～6; Radix Et Rhizoma Nardostachyos 2～4; Radix Curcumae 4～6;
Rhizoma Curcumae 2～4; Pericarpium Citri Reticulatae 3～5; Rhizoma Pinelliae 3～6;
Endothelium Corneum Gigeriae Galli 4～6.
2, the medicine of treatment peptic ulcer according to claim 1 is characterized in that described medicament is capsule or tablet.
3, a kind of method for preparing claim 1 or 2 described medicines that is exclusively used in is characterized in that may further comprise the steps:
(1) get Endoconcha Sepiae, Pseudobulbus Bletillae (Rhizoma Bletillae), Endothelium Corneum Gigeriae Galli, Rhizoma Coptidis mixed powder and be broken into the above fine powder of 100 orders, standby;
(2) get Rhizoma Corydalis, the Rhizoma Pinelliae mixed powder is broken into coarse powder, with 60%～80% ethanol is solvent, floods 20～72 hours according to the percolation under fluid extract and the extractum item, with the speed percolation of every kilogram of medicine 2～4ml/min, collection percolate total amount is equivalent to 6～10 times of medication amount, and medicinal residues are standby;
(3) get the percolate recovery ethanol that above-mentioned steps (2) obtains, be concentrated into relative density and be the thick paste of 1.30～1.40 (60 ℃), standby;
(4) get in the prescription that the medicinal residues behind the Rhizoma Corydalis and Rhizoma Pinelliae percolation merge in all the other medicines and above-mentioned steps (2), add 10～14 times of amounts of water, soaked 1～5 hour, decoct distillation 2～5 hours, collect volatile oil and with the dehydrated alcohol diluted for use, the filtrate decocting liquid is the 1st extract; Medicinal residues decoct 1～2 time again, add 8～10 times of amounts of water at every turn, decoct 1～2 hour, filter, and merge each time decocting liquid, and being concentrated into relative density is the thick paste of 1.30～1.40 (60 ℃), is incubated standby;
(5) getting step (3) percolation gained thick paste joins in the thick paste of above-mentioned steps (4) gained, mixing, again with the fine powder mixing of four Chinese medicine things such as Endoconcha Sepiae, drying, be ground into 20 order left and right sides coarse grain, sieve is got wherein part fine powder, increases progressively mixing with whole granules again after absorbing above-mentioned volatile oil, and airtight moistening is more than 2 hours, the magnesium stearate fine powder that adds granule total amount 0.8%～1.2%, mixing, encapsulated or tabletting promptly makes the capsule or the tablet of medicine of the present invention.
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| CN 03114590 CN1233364C (en) | 2003-04-01 | 2003-04-01 | Chinese medicine for treating digestive ulcerating sore and its preparation method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872289A (en) * | 2012-10-19 | 2013-01-16 | 黄庆德 | Traditional Chinese medicine composite for treating chronic gastritis and preparation method thereof |
| CN103110878A (en) * | 2012-12-10 | 2013-05-22 | 宋爱民 | Traditional Chinese medicine preparation for treating gastric upset |
| CN104436074A (en) * | 2014-12-24 | 2015-03-25 | 赵红 | Traditional Chinese medicine preparation for treating peptic ulcer and preparation method thereof |
| CN104474497A (en) * | 2014-11-11 | 2015-04-01 | 毕占岁 | Traditional Chinese medicine for treating peptic ulcer |
| WO2017000449A1 (en) * | 2015-06-30 | 2017-01-05 | 济南正骐生物科技有限公司 | Chinese medicine for treating digestive system ulceration and preparation method thereof |
-
2003
- 2003-04-01 CN CN 03114590 patent/CN1233364C/en not_active Expired - Lifetime
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102872289A (en) * | 2012-10-19 | 2013-01-16 | 黄庆德 | Traditional Chinese medicine composite for treating chronic gastritis and preparation method thereof |
| CN102872289B (en) * | 2012-10-19 | 2014-03-12 | 黄庆德 | Traditional Chinese medicine composite for treating chronic gastritis and preparation method thereof |
| CN103110878A (en) * | 2012-12-10 | 2013-05-22 | 宋爱民 | Traditional Chinese medicine preparation for treating gastric upset |
| CN103110878B (en) * | 2012-12-10 | 2014-08-13 | 宋爱民 | Traditional Chinese medicine preparation for treating gastric upset |
| CN104474497A (en) * | 2014-11-11 | 2015-04-01 | 毕占岁 | Traditional Chinese medicine for treating peptic ulcer |
| CN104436074A (en) * | 2014-12-24 | 2015-03-25 | 赵红 | Traditional Chinese medicine preparation for treating peptic ulcer and preparation method thereof |
| WO2017000449A1 (en) * | 2015-06-30 | 2017-01-05 | 济南正骐生物科技有限公司 | Chinese medicine for treating digestive system ulceration and preparation method thereof |
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| CN1233364C (en) | 2005-12-28 |
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Application publication date: 20041006 Assignee: SHAANXI MOMENTUM QIXUEHE PHARMACEUTICAL CO.,LTD. Assignor: Wang Baoan Contract record no.: 2018610000014 Denomination of invention: Chinese medicine for treating digestive ulcerating sore and its preparation method Granted publication date: 20051228 License type: Exclusive License Record date: 20180408 |
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