CN1092976C - Application of endive in preparing medicine for treating tuberculosis - Google Patents
Application of endive in preparing medicine for treating tuberculosis Download PDFInfo
- Publication number
- CN1092976C CN1092976C CN98112630A CN98112630A CN1092976C CN 1092976 C CN1092976 C CN 1092976C CN 98112630 A CN98112630 A CN 98112630A CN 98112630 A CN98112630 A CN 98112630A CN 1092976 C CN1092976 C CN 1092976C
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- China
- Prior art keywords
- traditional chinese
- chinese medicine
- tuberculosis
- novel
- medicine
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000003814 drug Substances 0.000 title claims abstract description 29
- 201000008827 tuberculosis Diseases 0.000 title claims abstract description 20
- 244000116025 chicria Species 0.000 title 1
- 235000003733 chicria Nutrition 0.000 title 1
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 230000000694 effects Effects 0.000 abstract description 10
- 239000002775 capsule Substances 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 3
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 241001301715 Crepidiastrum sonchifolium Species 0.000 abstract 3
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 229940079593 drug Drugs 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- -1 Lei Mifeng Chemical compound 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 230000002365 anti-tubercular Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000002547 new drug Substances 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 235000000208 Solanum incanum Nutrition 0.000 description 1
- 230000037006 agalactosis Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 208000004396 mastitis Diseases 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940100691 oral capsule Drugs 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 description 1
- 229960001225 rifampicin Drugs 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 239000000814 tuberculostatic agent Substances 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000002435 venom Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 210000001048 venom Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to application of ixeris sonchifolia hance in the aspect of the preparation of a medicament for treating tuberculosis. Ixeris sonchifolia hance or the ixeris sonchifolia hance and other medicaments are extracted by the modern scientific method to be prepared into a novel traditional Chinese medicine capsule. The novel traditional Chinese medicine capsule has strong suppression and sterilization functions to tubercle bacilli. The cure rate of 24 patients reaches 91.7% by the clinical observation of the 24 patients. The novel traditional Chinese medicine capsule has the advantages of obvious effect, good therapeutic effect, short therapeutic course, no medicine resistance, small side effect, convenient taking, etc. The present invention discovers and initiates the new purpose of the traditional Chinese medicine, invents a novel medicine for treating tuberculosis, and enriches and develops the traditional Chinese medicine theory of China.
Description
The present invention relates to the new application of a kind of medical material among the human lives, the particularly a kind of new purposes of Chinese elite medical tradition Chinese crude drug aspect preparation treatment tuberculosis medicine of excavating.
Since this century early fifties, with medicines such as streptomycin, Lei Mifeng, rifampicin, ethambutols is the sick scheme of Western medicine associating tuberculosis of representative, once on global tuberculosis history, brought into play enormous function, and made the disease of this threat human health of tuberculosis and life in quite long period, obtain effective control.But, along with the industrialized continuous development in the whole world, because Drug resistance continuous appearance lungy, and reasons such as war, famine, natural disaster, tuberculosis presents the ascendant trend of making us anxiety in recent years once more.Statistics according to World Health Organization's issue in 1996, nineteen ninety-five, the tuberculosis death toll reached 3,000,000 people, created tuberculosis dead top level in the whole world since 1850, the whole world has nearly 2,000,000,000 populations to be subjected to tubercle bacillus affection, existing 2,000 ten thousand tuberculosis patients, annual newfound tuberculosis case is 800-1000 ten thousand people.In the face of a kind of so severe situation, and the sick scheme of Western medicine associating tuberculosis is because the progress of not making a breakthrough property always for many years, drawbacks such as it is powerless more and more to seem, its long, weak curative effect and side effect big course of treatment more and more become problem extremely to be solved on the tuberculosis history.Therefore, World Health Organization (WHO) once appealed strongly, should seek new more effective antituberculotics as early as possible.In China, because economy and technology will be developed the chemosynthesis antituberculotics that makes new advances and have certain difficulty.So, develop and a kind of tubercule bacillus is had strong killing action and don't has Drug resistance and novel antitubercular agent that toxic and side effects is less, become the urgent urgent problem of present medical science.
Purpose of the present invention is intended to develop the new purposes of a kind of Chinese crude drug aspect the various tuberculosis medicines of preparation treatment.
Treatment of the present invention new Chinese medicinal capsule agent lungy is used Herba Ixeritis Denticulatae or is added other drug with Herba Ixeritis Denticulatae and makes.
(prescription): Herba Ixeritis Denticulatae 2650 grams
(processing technology): add 70% alcohol reflux secondary, add for the first time 5 times of amount alcohol refluxs 2 hours, filter, for the second time residue is added 4 times of amount alcohol refluxs 1.5 hours again, filter, merge filtrate twice, reclaim ethanol, and be concentrated into clear paste, residue adds decocting in water again and carries secondary, adding for the first time 7 times of water gagings boils and carries 1 hour, add for the second time 6 times of water gagings and boil and carry 1 hour, merge secondary water extract, vacuum concentration is to clear paste, merge the secondary clear paste, reconcentration to proportion is the thick paste of 1.3-1.4 (heat is surveyed), through vacuum drying, pulverize extract powder (about 450 gram), encapsulated, get about 1000 of capsule product, packing gets product.
(function cures mainly): parasite killing ends illness, and heat-clearing and toxic substances removing is used for the treatment of various tuberculosis.
The present invention treats tuberculosis with Herba Ixeritis Denticulatae, be the inventor on the basis of secret prescription handed down in the family from generation to generation, by science prerun and method of treatment and the prescription invent of clinical observation checking repeatedly, it enriches and has developed Chinese medical theory, has obtained significant curative effect.Said preparation has stronger inhibitory or killing effect to tubercule bacillus, and through 24 routine clinical observations, its cure rate reaches 91.7%.This medical instrument has following characteristics: 1. instant effect, and all cases all began to occur doing well,improving, two to seven all transference cures in the back of taking medicine in one to two week; 2. good effect, clinical observation reaches 91.7%, total effective rate 100% to the cure rate of pulmonary tuberculosis; 3. short treating period, the totally 90 days full course of treatment of this medicine, and do not see recurrent cases after the treatment; 4. there is not Drug resistance, is specially adapted to the refractory tuberculosis patient of anti-Western medicine, can save this part people's life; 5. side effect is little, has overcome that the western medicine toxic and side effects is big, some patient is reluctant to adhere to the shortcoming for the treatment of, and does not see tangible toxicity during taking this medicine; 6. easy to use, this medicine is an oral capsule, need not injection for curing, also need not take other ancillary drugs, and is very easy to use, and patient is willing to accept.
Herba Ixeritis Denticulatae another name dish grass, Herba Sonchi Oleracei, Herba Patriniae, Radix Patriniae heterophyllae, Herba monochoriae vaginalis, bitter ball dish, the beginning is stated from Shennong's Herbal, and the name Herba Sonchi Oleracei is classified as top grade.Its composition master contains flavonoid, coumarin, steroid terpenoid etc., and the nature and flavor hardship is slightly cold, and tool heat-clearing and toxic substances removing and detumescence function cure mainly lung abscess, acute mastitis, furuncle and phyma, traumatic injury, venom etc.Among the people also with it and his medicine compatibility treatment dysentery, puerperal agalactia, mouthful in give birth to diseases such as bubble, skin ulcer bleb, lower part of the body treatment skin ulcer, evident in efficacy.But never see about it and treat bibliographical information lungy.The present invention follows theory of Chinese medical science on the Therapeutic Principle, utilize the Herba Ixeritis Denticulatae preparation to kill tubercule bacillus, has found and started the new purposes of Chinese medicine, has invented treatment new drug lungy.
New drug of the present invention is to adopt modern scientific method to be refined Herba Ixeritis Denticulatae, makes capsule formulation, and this dosage form is applied to clinical, have preparation process advanced person, taking dose little, be beneficial to oral, be convenient to transportation and advantage such as carry.
Claims (1)
1, the purposes of Herba Ixeritis Denticulatae aspect preparation treatment tuberculosis medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112630A CN1092976C (en) | 1998-09-15 | 1998-09-15 | Application of endive in preparing medicine for treating tuberculosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98112630A CN1092976C (en) | 1998-09-15 | 1998-09-15 | Application of endive in preparing medicine for treating tuberculosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1247747A CN1247747A (en) | 2000-03-22 |
| CN1092976C true CN1092976C (en) | 2002-10-23 |
Family
ID=5222465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN98112630A Expired - Lifetime CN1092976C (en) | 1998-09-15 | 1998-09-15 | Application of endive in preparing medicine for treating tuberculosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1092976C (en) |
-
1998
- 1998-09-15 CN CN98112630A patent/CN1092976C/en not_active Expired - Lifetime
Non-Patent Citations (1)
| Title |
|---|
| 《中药大辞典》(第一版) 1986.5.1 江苏新医学院编，上海科技出版社出版 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1247747A (en) | 2000-03-22 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: HU'NAN TAILAI PHARMACEUTICAL DEVELOPMENT CO., LTD. Free format text: FORMER NAME: TAILAI MEDICINE DEVELOPMENT CO., LTD., HUNAN PROV. |
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| CP03 | Change of name, title or address |
Address after: 5, building 410005, front building, No. 287, Hunan Road, Hunan, Changsha Patentee after: Hunan Tailai Pharmaceutical Development Co., Ltd. Address before: 410005, 7 building, Xiang Xiang building, No. 86 Wuyi Road, Hunan, Changsha Patentee before: Tailai Medicine Development Co., Ltd., Hunan Prov. |
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| ASS | Succession or assignment of patent right |
Owner name: WUHU LUYE PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: HU'NAN TAILAI PHARMACEUTICAL DEVELOPMENT CO., LTD. Effective date: 20120522 |
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Free format text: CORRECT: ADDRESS; FROM: 410005 CHANGSHA, HUNAN PROVINCE TO: 241008 WUHU, ANHUI PROVINCE |
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| TR01 | Transfer of patent right |
Effective date of registration: 20120522 Address after: 241008 Anhui province Wuhu City Jiuhua Road No. 116 Patentee after: Wuhu Luye Pharmaceutical Co., Ltd. Address before: 5, building 410005, front building, No. 287, Hunan Road, Hunan, Changsha Patentee before: Hunan Tailai Pharmaceutical Development Co., Ltd. |
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| CX01 | Expiry of patent term |
Granted publication date: 20021023 |
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| CX01 | Expiry of patent term |