CN1089864A - Stopping narcotic taking Chinese patent medicine and preparation method thereof - Google Patents

Abstract

The present invention is a kind of Chinese patent medicine that makes junkie drug rehabilitation and rehabilitation.Mainly form by the effective component extracts of Radix Ginseng Rubra, Radix Aconiti Lateralis Preparata, Rhizoma Chuanxiong, the Radix Astragali, Cortex Cinnamomi, Bulbus Fritillariae Uninbracteatae, Poria, the Cortex Eucommiae, Fructus Schisandrae Chinensis, Plantula Papaveris, Radix Polygalae, Semen Ziziphi Spinosae, LONGMU, Radix Ophiopogonis and the Radix Paeoniae Alba.Wherein Radix Ginseng Rubra, the Radix Astragali and Poria ethanol extraction; Cortex Cinnamomi, Rhizoma Chuanxiong extract with the way of distillation, and all the other extract with decocting method, and each extract concentrates, mixes the back and granulates, and promptly get electuary type drug rehabilitation Chinese patent medicine.Evident in efficacy, the instant effect of this Chinese medicine, without any side effects.

Description

Stopping narcotic taking Chinese patent medicine and preparation method thereof

The invention belongs to drug class, is a kind of Chinese patent medicine and preparation technology thereof who makes junkie drug rehabilitation and rehabilitation.

The method of current domestic and international treatment junkie withdrawal syndrome mainly contains forces to give up and two kinds of methods of Drug therapy.Pressure is given up method and is appointed the outbreak of junkie drug addiction exactly, and all are let matters aside, and give up by force.This method will be brought very big misery to the patient, can be choked to death because of respiratory tract when serious and die.At present poisonous usually in the used medicine of drug therapy, the danger that the existence that has is certain; What have has detrimental effect to internal organs; The medicine that has itself also easily produces substituting dependence and causes other diseases, and its effect is not very good yet.

It is remarkable, without any side effects to the purpose of this invention is to provide a kind of drug abstinence, and the somatization of junkie is had stopping narcotic taking Chinese patent medicine of better therapeutical effect and preparation method thereof.

The applicant thinks: the main etiology and pathogenesis of the withdrawal syndrome shape that the addict showed is that lung spleen kidney yang weakness of QI is little, yin-cold excess due to.Deficiency of kidney-QI is weak, insufficiency of kidney-YANG, is afraid of cold waist knee joint limbs pain so fear of cold occurs; Insufficiency of lung-QI, weakened defensive QI, the sweating so appearance is coughed, watery nasal discharge are beaten and are owed; Taste are impaired, and fortuneization function mistake department is so anorexia; And the Mental fatigue weak breath is weak, pale complexion is unglazed, down in spirits, is that deficiency of YANG QI is weak, the sign of insufficiency of vital energy and blood.So in treatment, should be core with conditioning lung spleen kidney three dirty functions, rouse oneself three dirty yang-energies, tonifying for deficiency syndrome, QI and blood regulating makes the yang blood and qi of body be able to balance again, thereby reaches the purpose of therapy rehabilitation.

According to above view, stopping narcotic taking Chinese patent medicine provided by the present invention mainly is made up of the active ingredient extract of following material, and the percentage by weight of these storerooms is:

Radix Ginseng Rubra 9.2-12.1%; Radix Aconiti Lateralis Preparata 4.2-6.4%;

Rhizoma Chuanxiong 1.5-2.8%; Radix Astragali 22.6%-28.4%;

Cortex Cinnamomi 2.3-4%; Bulbus Fritillariae Uninbracteatae 8-11%;

Poria 6.8-9.5%; Cortex Eucommiae 4.2-6.4%;

Fructus Schisandrae Chinensis 3-4.8%; Plantula Papaveris 0.7-1.7%;

Radix Polygalae 3.1-5.1%; Semen Ziziphi Spinosae 4.2-6.4%;

LONGMU 9.2-12.1%; Radix Ophiopogonis 2.3-4%;

Radix Paeoniae Alba 2.3-4%.

But Radix Ginseng Rubra, Radix Aconiti Lateralis Preparata, Rhizoma Chuanxiong, the Radix Astragali, Cortex Cinnamomi, Bulbus Fritillariae Uninbracteatae, Poria, the Cortex Eucommiae, Fructus Schisandrae Chinensis strengthening heart and replenishing qi, strongly invigorating QI and blood in above-mentioned material; Radix Aconiti Lateralis Preparata, interior osmanthus, Plantula Papaveris, but kidney invigorating and YANG supporting, astringent therapy antidiarrheal; But Radix Ginseng Rubra, the Radix Astragali, Poria benefiting qi and supporting yang, spleen benefiting and stimulating the appetite; Radix Ginseng Rubra, Bulbus Fritillariae Uninbracteatae, Poria, Radix Polygalae, but QI invigorating tonifying the lung, relieving cough and resolving phlegm; Semen Ziziphi Spinosae, Radix Polygalae, LONGMU, can allay excitement calmness, tranquilizing by nourishing the heart; Rhizoma Chuanxiong, the Cortex Eucommiae, the Radix Paeoniae Alba, the muscle that can soften, strong waist pain relieving.All medicines share, and effect is concentrated one's efforts grand, and treating both the principal and secondary aspects of a disease can make the function of lung spleen kidney imbalance rouse oneself, and is able to tonification a little less than the deficiency of YANG QI, the QI and blood blending, and equilibrium between yin and yang, the withdrawal syndrome shape is fully recovered naturally.

The preparation method of stopping narcotic taking Chinese patent medicine provided by the present invention is:

(1), with each material pulverize separately, sieve,

(2), Radix Ginseng Rubra, the Radix Astragali, Poria press percolation with ethanol and extract working substance, and is condensed into thick paste,

(3), Cortex Cinnamomi, Rhizoma Chuanxiong be condensed into thick paste with extracting solution after removing volatile oil with the way of distillation,

(4), unclassified stores adopts decocting method to extract, and is condensed into thick paste,

(5), the thick paste of above-mentioned (2), (3), (4) is mixed, and further concentrate,

(6), add dextrin, starch is granulated, and promptly gets this Chinese patent medicine.

The ethanol that extracts Radix Ginseng Rubra among above-mentioned 2 can be 60-95%; The ethanol that extracts the Radix Astragali can be 50-80%; The ethanol that extracts Poria can be 25-60%.

Example

Material proportion (unit: gram)

Radix Ginseng Rubra 1000 Radix Aconiti Lateralis Preparatas 500 Rhizoma Chuanxiongs 200 Radixs Astragali 2400

Cortex Cinnamomi 300 Bulbus Fritillariae Uninbracteataes 900 Poria 750 Cortexs Eucommiae 500

Fructus Schisandrae Chinensis 350 Plantula Papaveris 100 Radix Polygalaes 400 Semen Ziziphi Spinosaes 500

The LONGMU Radix Paeoniae Alba 300 1000 Radix Ophiopogonis 300 amounts to 9500 grams.

(1) Radix Ginseng Rubra 60% ethanol, the Radix Astragali 50% ethanol, Poria are made solvent with 25% ethanol and are extracted,

(2) Cortex Cinnamomi, Rhizoma Chuanxiong extract with the way of distillation,

(3) unclassified stores extracts with the decocting method method,

(4) further be concentrated to proportion 1.31/90 after the thick paste mixing with each extract, add dextrin 540 grams, starch 540 grams then, make block, fine powder is made in dry back, makes granule in right amount with 75% ethanol, promptly gets this Chinese patent medicine after the cold drying.

The conventional amount used of this Chinese medicine: clothes were three bags in 1 to 3 day per 3 hours; Clothes were two bags in 4 to 6 days per three hours; 7 to 15 day every day be early, middle and late respectively obeys one bag, and every bag 8 gram (quite crude drug in whole 5 grams) 15 days was a course of treatment with mixing in water for oral taking.

The acute toxicity testing of this Chinese medicine:

To the disposable gastric infusion of mice.None death of laboratory animal, its behavior, ingest, drain normal; Dissecting the back main organs there is no unusually.

The main pharmacodynamics experiment of this Chinese medicine:

With hot plate method, writhing method mice is carried out the analgesic test, the result shows that this Chinese medicine has significant analgesia role; Calm result of the test shows the spontaneous activity that can obviously suppress mice, and the dependency of morphine is had significant inhibitory effect.

The clinical observation result of this Chinese medicine is as shown in the table:

Symptom	The example number	Produce effects	Effectively	Invalid	Effectively total
						Withdrawal symptom	40	28	11	1	97.5%
Mental symptom	40	23	16	1	97.5%
						Somatization	32	20	12		100%

More than 19-30 year person 23 people in 40 junkie, 30-40 year person 12 people, person 5 people more than 40 years old; The elder of history of drug abuse reaches 4 years, and the shortest person is surplus February; Course of treatment of 40 philtrums, 22 human therapies, two courses of treatment of 18 human therapies.Above-mentioned 2 routine nonresponders tie up in the therapeutic process therapy discontinued for some reason, so neutralize.

From as can be known above: the effective percentage of this Chinese medicine against drug dependence is higher, reliable rapidly, without any side effects, the easy to use safety of curative effect, and the patient is acceptant.Above-mentioned clinical observation shows that this Chinese medicine can be alleviated the symptom that is occurred quickly, the misery when alleviating the drug addiction outbreak.After taking this Chinese medicine for the person that should the withdrawal symptom occur, can make it be in steady statue for a long time, thereby balance is tided over the withdrawal symptom phase, reach the purpose of drug rehabilitation.

Claims (2)

1, a kind of stopping narcotic taking Chinese patent medicine mainly is made up of the active ingredient extract of following material, and the percentage by weight of these storerooms is:

Radix Ginseng Rubra 9.2-12.1%; Radix Aconiti Lateralis Preparata 4.2-6.4%;

Rhizoma Chuanxiong 1.5-2.8%; Radix Astragali 22.6-28.4%;

Cortex Cinnamomi 2.3-4%; Bulbus Fritillariae Uninbracteatae 8-11%;

Poria 6.8-9.5%; Cortex Eucommiae 4.2-6.4%;

Fructus Schisandrae Chinensis 3-4.8%; Plantula Papaveris 0.7-1.7%;

Radix Polygalae 3.1-5.1%; Semen Ziziphi Spinosae 4.2-6.4%;

LONGMU 9.2-12.1%; Radix Ophiopogonis 2.3-4%;

Radix Paeoniae Alba 2.3-4%.

2, the preparation method of the described Chinese patent medicine of claim 1,

(1), with each material pulverize separately, sieve,

(2), Radix Ginseng Rubra, the Radix Astragali, Poria press percolation with ethanol and extract working substance, and is condensed into thick paste,

(3), Cortex Cinnamomi, Rhizoma Chuanxiong be condensed into thick paste with extracting solution after removing volatile oil with the way of distillation,

(4), unclassified stores adopts decocting method to extract, and is condensed into thick paste,

(5), the thick paste of above-mentioned (2), (3), (4) is mixed, and further concentrate,

(6), add dextrin, starch is granulated, and promptly gets this Chinese patent medicine.