WO2002094297A1 - Herbal composition for the treatment of drug addiction and insomnia - Google Patents
Herbal composition for the treatment of drug addiction and insomnia Download PDFInfo
- Publication number
- WO2002094297A1 WO2002094297A1 PCT/AU2002/000649 AU0200649W WO02094297A1 WO 2002094297 A1 WO2002094297 A1 WO 2002094297A1 AU 0200649 W AU0200649 W AU 0200649W WO 02094297 A1 WO02094297 A1 WO 02094297A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- root
- parts
- radix
- composition according
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/22—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- This invention relates to compositions derived using traditional Chinese medicine practices and to the use of such compositions in the treatment of human diseases and disorders.
- the invention relates to a treatment of drug addiction and insomnia by administering to a patient a novel combination of Chinese herbs and extracts.
- Drug addiction in particular opiate addiction, and insomnia are major health problems and the successful treatment of these conditions poses a great challenge to the medical profession.
- methadone is itself addictive and its use in withdrawal is restricted to treatment periods of not more than a few weeks to carry the addict through the acute withdrawal stage. Methadone is not a good agent for maintaining abstinence from the drug after withdrawal is achieved. As a result, the relapse rate after Methadone - based treatment is high.
- the present invention is based on the discovery that some compositions of Chinese herbs have a powerful effect in blocking drug addiction and treatment of insomnia. It is an object of the present invention to provide an effective non-opiate based treatment which avoids one or more of the disadvantages of current treatment.
- the invention resides in a composition including borax, ginseng and gentian root, or extracts thereof.
- the invention resides in a composition which further includes chicken's gallbladder or extract thereof.
- the invention resides in a composition including borax, ginseng and gentian root, Chinese lobelia and/or notoginseng, or extracts thereof.
- the invention resides in a composition which further includes one or more of oyster shell, white peony, rhubarb, ginger, unsalted fermented soybean, gardenia flower, scutellari root, unripe bitter orange, houttunyia, bupleurum root, licorice, gizzard lining, spiny jujube kernel, peanut leaf and manyprickle acanthopanax root, or extracts thereof.
- the invention resides in a medicament for the treatment of drug addiction and insomnia including an effective amount of any one of the compositions described above.
- the invention resides in a method for treating drug addiction and insomnia in a patient including administering to said patient an effective amount of any one of the compositions described above.
- the invention resides in a method for preparing any one of the compositions described above. DESCRIPTION OF PREFERRED EMBODIMENTS
- composition according to the invention can be manufactured from the following components (English/Latin):
- Borax (Borax) 0.5-8 parts, preferably 1-4 parts
- Ginseng (Radix Ginseng) 0.5-4 parts, preferably 0.8-2.1 parts
- Gentian root (Radix Gentianae) 0.5-8 parts, preferably 1-4 parts 4.
- Notoginseng root (Notoginseng Radix) 0-4 parts, preferably 1 -2.1 parts
- Oyster shell (Concha Ostreae) 0-9 parts, preferably 2-5 parts 8.
- White peony (Radix Paeoniae Albae) 0 - 11 parts, preferably 2.2-6.2 parts
- Rhubarb (Rhizoma Rhei) 0-9 parts, preferably 2-5 parts
- Fresh ginger (Zingiberis Rhizoma Recens) 0-11 parts, preferably 2.1-6.2 parts
- Scutellari root Scutellariae Radix 0-4.5 parts, preferably 1-2.2 parts
- Unripe bitter orange (Aurantii Fructus Immaturus ) 0.4-5 parts, preferably 1.2-2 parts
- Houttuynia Houttuyniae Herba Cum Radice
- Bupleurum root 0-4 parts, preferably 1-2 parts
- Chicken Gizzard Lining (Endothelium Corneum Gigeriae Galli) 0-10 parts, preferably 2.2-5.2 parts
- Licorice (Radix Glycyrrhizae) 0 - 11 parts, preferably 2.2 - 6.2 parts
- the appropriate amounts of cut herbal pieces were first soaked together in water at a temperature of 30-60°C for 2-4 hours.
- Extract of borax and oyster shell was produced by placing in alcohol at a temperature of 60-70°C for 24-48 hours, a cycle that was repeated three times. The alcohol must cover the oyster shells and borax.
- Extract of ginseng and notoginseng root was produced by decoction in water for 40 minutes repeated three times.
- the extract of rhubarb was prepared by decocting the cut rhubarb pieces in water for a session of 15 minutes followed by two sessions of 20 minutes.
- the remaining herbs were prepared together by decocting three times in water for 30 minutes.
- Gizzard lining may be soaked and decocted together with other herbal pieces.
- a liquid extract pressed from the chicken's gallbladder may be added to the liquids extracted from the herbal pieces, borax, gizzard lining, and oyster shells. The obtained mixture is then distilled and evaporated to produce a dry powder.
- the dry powder may be placed in capsules, each capsule containing 0.5 g of the powder.
- the dosage may be varied according to the condition treated and the concentration of active ingredients used. Thus, consumption of 4-5 capsules orally every eight hours is recommended for treatment of drug addiction.
- the dosage for treatment of insomnia is 2 capsules orally 4 hours prior to a normal sleeping period, followed by 2 capsules orally 0.5 hour prior to said normal sleeping period.
- opiate intake was abruptly stopped and treatment commenced after 10 hours.
- Patients receiving the new treatment received 6-8 capsules, modified according to body weight and heroin usage, orally every four hours for up to 10 days.
- Patients receiving methadone were administered a dose according to body weight and heroin use, the dose being decreased at a rate of 25% per day to zero over 10 days.
- the patients were assessed and scored by trained nurses according to the severity of classic withdrawal symptoms exhibited by the patient.
- the symptoms assessed were nausea, stomach cramps, muscle spasms, feelings of coldness, heart pounding, muscular tension, aches and pains, yawning, watery eyes, insomnia, lachrymation and perspiring.
- the patients also underwent a self examination where they were asked to rate their own feelings of calmness, anger, cold turkey, drug craving, dry mouth, drowsiness and general well being.
- the new composition of the invention as a treatment of drug addiction compares favourably with methadone, a well known drug replacement therapy.
- the present invention has a further advantage in that it is a non-opiate based treatment and thus does not have the addictive side-effects that methadone can sometimes have.
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPR5207 | 2001-05-23 | ||
AUPR5207A AUPR520701A0 (en) | 2001-05-23 | 2001-05-23 | Herbal composition for the treatment of drug addiction |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002094297A1 true WO2002094297A1 (en) | 2002-11-28 |
Family
ID=3829185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU2002/000649 WO2002094297A1 (en) | 2001-05-23 | 2002-05-23 | Herbal composition for the treatment of drug addiction and insomnia |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN1463192A (en) |
AU (1) | AUPR520701A0 (en) |
WO (1) | WO2002094297A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1393737A1 (en) * | 2002-08-28 | 2004-03-03 | Tokiwa Kanpo Pharmaceutical Co., Ltd. | Pharmaceutical compositions and health foods for preventing and treating male sterility comprising oyster extract and ginseng extract |
CN103705700A (en) * | 2013-12-27 | 2014-04-09 | 刘洪凤 | Topical lotion for promoting to heal bone fractures |
US9675542B2 (en) | 2011-05-16 | 2017-06-13 | Colgate-Palmolive Company | Oral care compositions |
CN106890223A (en) * | 2017-03-24 | 2017-06-27 | 珠海康德瑞戒毒中药研发有限公司 | A kind of Chinese medicinal composition for detoxification and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1031327A (en) * | 1988-07-07 | 1989-03-01 | 买耀华 | A kind of manufacture method for the treatment of the tracheitis, asthma Chinese patent medicine |
CN1076627A (en) * | 1993-02-09 | 1993-09-29 | 马留文 | External use health-care medicine and medicated bag thereof |
CN1100320A (en) * | 1994-03-10 | 1995-03-22 | 王申 | Dysphagia pills |
CN1244387A (en) * | 1999-07-16 | 2000-02-16 | 王广德 | Flexible gelatin for beautifying massage |
CN1291497A (en) * | 2000-10-09 | 2001-04-18 | 李观群 | Mother liquid medicine for treating liver cancer and its preparing process |
-
2001
- 2001-05-23 AU AUPR5207A patent/AUPR520701A0/en not_active Abandoned
-
2002
- 2002-05-23 WO PCT/AU2002/000649 patent/WO2002094297A1/en active IP Right Grant
- 2002-05-23 CN CN02801819A patent/CN1463192A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1031327A (en) * | 1988-07-07 | 1989-03-01 | 买耀华 | A kind of manufacture method for the treatment of the tracheitis, asthma Chinese patent medicine |
CN1076627A (en) * | 1993-02-09 | 1993-09-29 | 马留文 | External use health-care medicine and medicated bag thereof |
CN1100320A (en) * | 1994-03-10 | 1995-03-22 | 王申 | Dysphagia pills |
CN1244387A (en) * | 1999-07-16 | 2000-02-16 | 王广德 | Flexible gelatin for beautifying massage |
CN1291497A (en) * | 2000-10-09 | 2001-04-18 | 李观群 | Mother liquid medicine for treating liver cancer and its preparing process |
Non-Patent Citations (5)
Title |
---|
DATABASE WPI Derwent World Patents Index; AN 1990-052007 * |
DATABASE WPI Derwent World Patents Index; AN 1994-209200 * |
DATABASE WPI Derwent World Patents Index; AN 1997-245837 * |
DATABASE WPI Derwent World Patents Index; AN 2000-476560 * |
DATABASE WPI Derwent World Patents Index; AN 2001-426194 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1393737A1 (en) * | 2002-08-28 | 2004-03-03 | Tokiwa Kanpo Pharmaceutical Co., Ltd. | Pharmaceutical compositions and health foods for preventing and treating male sterility comprising oyster extract and ginseng extract |
US9675542B2 (en) | 2011-05-16 | 2017-06-13 | Colgate-Palmolive Company | Oral care compositions |
CN103705700A (en) * | 2013-12-27 | 2014-04-09 | 刘洪凤 | Topical lotion for promoting to heal bone fractures |
CN106890223A (en) * | 2017-03-24 | 2017-06-27 | 珠海康德瑞戒毒中药研发有限公司 | A kind of Chinese medicinal composition for detoxification and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
AUPR520701A0 (en) | 2001-06-14 |
CN1463192A (en) | 2003-12-24 |
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