CN100459999C

CN100459999C - Medicine for treating rheumatism

Info

Publication number: CN100459999C
Application number: CNB2006101696114A
Authority: CN
Inventors: 程宪福
Original assignee: Individual
Current assignee: Individual
Priority date: 2006-12-25
Filing date: 2006-12-25
Publication date: 2009-02-11
Anticipated expiration: 2026-12-25
Also published as: CN1985936A

Abstract

The rheumatism treating medicine is prepared with six kinds of Chinese medicinal materials, including white mustard seed, arisaema tuber, monkshood, acuteangular anisodus and shorstalk monkshood root in certain weight proportion and through mixing and grinding into powder for applied to the affected part. Into the materials, other seven kinds of Chinese medicinal materials, including asarum herb, gecko, etc may be also added. The medicine has the functions of dispelling wind, cold and dampness, strengthening physique, dredging meridian, promoting blood circulation, eliminating phlegm and relieving pain. It is used in treating rheumatalgia, arthralgia, neuralgia and other diseases caused by wind, cold and dampness.

Description

A kind of medicine for the treatment of rheumatism

Technical field

The invention discloses a kind of external used medicine, particularly relate to a kind of external card drug of topical application thing for the treatment of rheumatism.

Background technology

Rheumatism, rheumatoid disease are present a kind of common symptons.According to the preliminary statistics, China has at least 5,000 ten thousand people to suffer from osteoarthritis in 100,000,000 old peoples, and along with the raising day by day of people's living standard, rheumatism, rheumatoid arthritis are increasing.What usually adopt is the medicine of anti-inflammatory analgesic, as indometacin, chlofenamic acid, cortisone, Radix Tripterygii Wilfordii etc., and the bigger side effect of this class medicine ubiquity, secular taking all has infringement to patient's gastrointestinal tract, mucocutaneous, conscience, kidney and reproductive system.The secular office work of modern metropolitan cities people causes arthralgia through regular meeting, and scapulohumeral periarthritis, diseases such as pain of neck, shoulder, waist and leg, these diseases also are that a stadium is long, and therapeutic effect is disease slowly; And old sprain and contuse, hyperosteogeny are perplexing people for a long time, and common therapy length consuming time, curative effect are not clearly yet.

Summary of the invention

At the toxic and side effects of existing treatment rheumatism medicine existence and the problem of growing the course of treatment, the invention provides a kind of safety and have no side effect, and make simple, easy to use, the medicine of instant effect is a well progress for diseases such as treatment rheumatism, rheumatoid classes.

A kind of medicine for the treatment of rheumatism is characterized in that it mainly is made up of following parts by weight raw material: 3-7 parts of 6-10 parts of Semen Sinapis Albaes, 2-6 parts of Arisaema Cum Bile, 3-7 parts of Radix Aconiti Kusnezoffii, 4-8 parts of Radix Aconiti, 3-7 parts of Radix Anisodi Acutangulis and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s.

Wherein raw material also has: 2-6 parts of 0.1-3 parts of Herba Asari, 0.1-3 parts of Gekko Swinhoniss, 0.1-3 parts of Herba Saussureae Involuerataes, 0.1-4 parts of Rsdix Wisterinae Venustaes, 0.1-2 parts of Sanguis Draxonis, 0.1-2 parts of Borneolum Syntheticums and Radix Sophorae Flavescentiss.

Described parts by weight can be: 5 parts of 8 parts of Semen Sinapis Albaes, 4 parts of Arisaema Cum Bile, 5 parts of Radix Aconiti Kusnezoffii, 6 parts of Radix Aconiti, 5 parts of Radix Anisodi Acutangulis and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s.

Described parts by weight can be: 4 parts of 1 part of Herba Asari, 1 part of Gekko Swinhonis, 1 part of Herba Saussureae Involueratae, 2 parts of Rsdix Wisterinae Venustaes, 0.5 part of Sanguis Draxonis, 0.5 part of Borneolum Syntheticum and Radix Sophorae Flavescentiss.

The Semen Sinapis Albae Tang Materia Medica

Different name: peppery Lay " Chinese medicinal herbal ".Base is former: be the seed of crucifer Caulis et Folium Sinapis albee Brassica alba (L) Boiss.Former plant is seen " Caulis et Folium Sinapis albee " bar for details.

Composition: Semen Sinapis Albae contains Sinapine glucosinalbate., sinapic acid choline ester., sinapic acid, fat, protein and phlegmatic temperament.Sinapine glucosinalbate. and sinapine bisulfate (sinapine bisulfate) and glucose.Sinapine bisulfate can generate sinapic acid and choline through basic hydrolysis.

Pharmacology: Sinapine glucosinalbate., itself has no stimulation, and meets water after the effect of myrosase generates ethereal oil (white mustard oil).Nature and flavor: Xin Wen.Gui Jing: go into lung, stomach warp.

Function cures mainly: promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, removing obstruction in the collateral to relieve pain.Control phlegm retention and cough and kick, costa sternales distension pain, regurgitation vomiting, aphasia due to apoplexy, limbs arthralgia pain numbness, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.

External: grind into powder to transfer and loose.

Compatibility and incompatibility of drugs: the deficiency of the lung is coughed loudspeaker, the hyperactivity of fire caused by deficiency of YIN person avoids clothes.

Arisaema Cum Bile (supplement to the Herbal)

Different name: the tiger palm (" herbal classic "), Rhizoma Pinelliae essence (Hou Ningji " medicine spectrum "), the snakehead Rhizoma Arisaematis (" is carried out

The rock book on Chinese herbal medicine "), Rhizoma Arisaematis, rabbit palm Rhizoma Arisaematis, Adeps Tigris (" detailed outline "), Serpentis taro (" Zhiwu Mingshi Tukao "), Serpentis Semen Maydis (" the Kunming medicine is planted investigation report "), mountain maize (" Liaoning main Chinese medicinal materials "), three ears of maize, medicine Canis familiaris L. pellet (" Hebei medical material "), big flat crow Fructus Colocasiae Esculentae (" Shandong Chinese medicine "), speckle cane (" Nanning City's medicine will "), Rhizoma Amorphophalli (" Zhejiang pesticide will "), YEYUTOU (" the Chinese crude drug handbook), letterwood taro (" south mainly contains poisonous plant ").

Base is former: be the tuber of aroid Rhizoma Arisaematis, arisaema amurense Maxim or Arisaema heterophyllum B1. etc.

Composition: 1. the Rhizoma Arisaematis tuber contains triterpenoid saponin, benzoic acid, starch, aminoacid.② Gui Rhizoma amorphophalli contains Saponin, and fruit contains the material of similar coniine (coniine).

Pharmacology: 1. anticonvulsant action: rabbit lumbar injection Gui Rhizoma amorphophalli decoct 1.2 gram/kilograms, can improve electric spasm threshold; But maximal electroshock outbreak to rat; Lumbar injection 6-9 gram/kilograms are also invalid.Mouse peritoneal injection water preserved material 3 gram/kilograms can obviously reduce the convulsions rate and the mortality rate of strychnine, also can obviously reduce the convulsions rate that leptazol and caffeine cause mice, and the outbreak of mice maximal electroshock is not then had influence.Other has stomach lumbar injection Rhizoma Arisaematis (not identification of species) decoct 9 gram/kilograms, and the convulsions and the death that can not resist strychnine and leptazol may be because kind difference or active ingredient be destroyed by high temperature.It is generally acknowledged strychnine convulsions is shown that effectively this product can be used for treating tetanus, leptazol convulsions is effectively shown can be used for treating petit mal epilepsy, invalid to the maximal electroshock outbreak, thereby can be invalid to epilepsy grand mal according to a preliminary estimate.Mouse muscle injection tetanus extracellular toxin to be to cause experimental tetanus, begin simultaneously subcutaneous injection fluid extract 0.32-0.8 gram/only/day, the effect of postponing animal dead is arranged.Rabbit intramuscular injection tetanus extracellular toxin to be to cause experimental tetanus, gavage five brave Chinese medicine Zhuifengsans (forming) every day and can make morbidity animals survived time lengthening by Rhizoma Arisaematis, RHIZONA GASTRODIAE, Periostracum Cicadae, Cinnabaris, Bombyx Batryticatus, Scorpio etc., but can not rabbit in death.The effect that has pair tetanus to faint from fear during lumbar injection is injected that antagonism strychnine to mouse peritoneal, the convulsions death that leptazol, cocaine and nicotine cause, and part is eliminated the caused muscular tremor of nicotine.

2. spasmolytic and analgesic effect: after the rabbit lumbar injection ghost Rhizoma amorphophalli decoct performance quiet, also the performance peace and quiet are motionless behind rat injection 6-9 gram/kilograms, weakness, the former attack attitude disappearance that pre-exists.The length of one's sleep of injected in mice 3 gram/kilograms energy significant prolongation pentobarbital sodium.Five brave Chinese medicine Zhuifengsans also can prolong the length of one's sleep of ciclobarbital soluble to mice.Mouse peritoneal injection decoct has tangible analgesic effect.(hot plate method).

3. phlegm-dispelling functions: the oral Gui Rhizoma amorphophalli of rabbit decoct 1 gram/kilogram, can significantly increase the respiratory mucus secretion, phlegm-dispelling functions has been described.

4. antitumor action: bright Rhizoma Arisaematis (not identification of species) aqueous extract (cryoconcentration, adding ethanol precipitates, getting supernatant concentration makes) there is inhibitory action in test tube when test to the Hela cell when 1:8-1:32 concentration, cell concentration becomes agglomerate, forfeiture normal cell structure, the part cell detachment, the mouse experiment tumor is comprised sarcoma-180, HCA (hepatocarcinoma) solid type, U14 (transplanting in the mice person) intramuscular injection every day aqueous extract 0.1ml (the bright Rhizoma Arisaematis of 1 gram)/only for phosphorus columnar epithelium type cervical cancer, tangible tumor-inhibiting action is arranged, may be wherein one of anticancer active ingredient, but very unobvious to the Hela cell inhibiting.

Toxicity: Rhizoma Arisaematis (not identification of species) rhizome has been eaten the strong impulse effect raw, and oral mucosa is slightly rotten to the corn, even partial necrosis comes off dry laryngopharynx, and burn feeling is arranged, tongue body enlargement, lip edema, a large amount of sialorrheas, the dispute numbness, gustatory anesthesia, hoarseness, difficulty in opening mouth.Mouse peritoneal injection Gui Rhizoma amorphophalli infusion median lethal dose(LD 50) is 13.5 gram/kilograms.Nature and flavor: toil, wet, poisonous.Gui Jing: go into lung liver, spleen channel.

Function with cure mainly: drying dampness to eliminate phlegm, expelling wind for relieving convulsion, dispersing swelling and dissipating binds.Wind-phlegm is stopped up in controlling, and mouthful eye is oblique, hemiplegia, and epilepsy, infantile convulsion, tetanus, dizziness due to wind-phlegm, sore throat, scrofula, carbuncle, the traumatic injury folding is hindered snake bite and insect sting.

Compatibility and incompatibility of drugs: deficiency of YIN dry phlegm and not being taken by pregnant women.

Radix Aconiti Kusnezoffii (Radix Aconiti Kusnezoffii, Hou Ningji " medicine spectrum ")

Different name: violet (" village "), splendid achnatherum (" elegant "), Aconitum carmichjaelii Debx., black beak, why poison (" book on Chinese herbal medicine "), chicken poison (" Huainan "), gelsemium, eternal lasting, poison is public, fruit is negative, Geng Zi, Supreme Being's autumn (" WU Pu Bencao "), Radix Aconiti Kusnezoffii grass (" continuous Chinese book "), Odontobutis obscura (T. Et S.) (" Japan hanako materia medica "), Radix Aconiti Kusnezoffii (" Shengji Zonglu "), ring Aconitum carmichjaelii Debx., golden crow (" detailed outline "), Gelsemium elegans Benth. (" Xinjiang medical material ").

Base is former: be the tuber of ranunculaceae plant Aconitum carmichjaelii Debx. (wild species), Aconitum kusnezoffii Reichb or other multiple congeners.

Composition: Aconitum carmichjaelii Debx. Aconieum chinese each several part contains alkaloid, wherein main for aconitine (Aconitine), generates aconine (Aconine) acetic acid and benzoic acid after the aconitine hydrolysis.Also contain inositol (Inosito) and tannin in the leaf.

Aconitum Karadkolicum Rap. contains aconitine, songorine, songoramine, karacoline, karacolidine, aconifine.Accurate Ge Er aconite root total alkaloids amount 1.5% is mainly aconitine, and songorine, aerial parts contain total alkaloids amount 0.7%, are mainly songorine.It is pseudo-aconitine that the Yadong aconitine contains alkaloid.

Radix Arnebiae (Radix Lithospermi) crow aerial parts (leaf and stalk) contains alkaloid 0.58%, wherein tells the crystallization alkaloid and claims delavaconitine 0.43%.It is reported that Japan produces Aconitum carmichjaelii Debx. except that containing aconitine and mesaconitine, also has hypaconitine, ignavine.

Pharmacology: Radix Aconiti Kusnezoffii (kind is not identified) has stronger analgesic activity with woolfe-Macdonald method test, as with the Radix Gentianae Macrophyllae compatibility.Its analgesia is renderd a service and can be strengthened mutually.Radix Aconiti Kusnezoffii is after the Radix Glycyrrhizae Semen sojae atricolor is concocted, and toxicity reduces and do not influence its analgesia and render a service.Radix Glycyrrhizae Mel has Detoxication to Radix Aconiti Kusnezoffii.The effect of Radix Aconiti Kusnezoffii and Radix Aconiti is basic identical, the former alkaloid 0.425%, and the latter 0.599%.

The total alkali that proposes in the Aconitum Karadkolicum Rap., 10-20 milligrams/kilograms are injected in anesthetized dog and rabbit, and visible heart beating irritability and conduction get muddled from the electrocardiogram.

The alkaloid that proposes in the autocollimatic Ge Er aconite root surpasses more than 30 kinds, songorine belongs to Atisine one class, with its 400mg/ kilogram subcutaneous injection, can make the white mice spontaneous activity reduce the tetanic property of hind leg contraction sometimes, rabbit there is weak sedation, and can prolong mice with the anesthesia duration that hypnotic causes, being used for rabbit has cooling effect, but the intravenous injection blood pressure lowering, heavy dose of can block nerves saving has the weak M-choline-like effect of separating.The tincture external can be used as analgesic, with the treatment neuralgia, and migraine etc., its analgesic effect mainly comes from aconitine, and toxicity is very big.

The Radix Arnebiae (Radix Lithospermi) crow: 1. local anesthesia effect, from the leaf of Radix Arnebiae (Radix Lithospermi) crow and stem, separate delavaconitine, its 1% solution has the local anesthesia effect, renders a service to be equivalent to cocaine and to get 2 times, and delavaconitine is injected in around the rat thigh rear side sciatic nerve, can produce conduction block; People's snakehead there are acupuncture and feeling of numbness.With delavaconitine solution heating or be positioned over room temperature 2-3 months, all do not lose efficacy.Isoaconitine 0.02% solution has more weak local anesthesia effect to adding rabbit corneal.It is injected in around the white mice thigh rear side sciatic nerve, can makes it to produce conduction block, but local anaesthesia stimulates obviously, and easily absorb and poison, so undesirable.2. analgesic activity: test with woolfe-Macdonald method, delavaconitine can not improve the threshold of pain in a small amount, and a large amount of beginnings, effectively its analgesia index was very low.The forest land Aconitum carmichjaelii Debx. has excitation, makes the heart shrink reinforcement isolated frog heart, and frequency is accelerated, perfusion distends the blood vessels in stripped frog liver, boosts in a small amount, suppresses cardiovascular in a large number, hungry animal capable is made the very fast recovery of its body weight, and the oral back of normal dogs, rabbit weight increase is faster.

The composition that Japan produces can suppress purine class diuresis, but saline diuretic is not had influence, with alkali without a head essential difference is arranged.A.gigas L.et V. is poison extremely, can make the cattle death of herding; Wherein contained alkaloid mainly suppresses motor nerve ending, and similar curariform action mask is arranged.The root of A.spicatum stapf, the rat that the injection yeast is caused has refrigeration function, and mouse writhing reaction and the mechanical pain that causes are had analgesic activity, and analgesia therapy index height illustrates safer.A.heterophyyllumWall. the oral or intramuscular injection of composition Atisine does not have refrigeration function to the rabbit that generates heat, and intravenous injection can slight blood pressure lowering.

Nature and flavor: suffering, heat, poisonous.

Gui Jing: go into liver, spleen, lung meridian.

Function cures mainly: search wind prevailing over dampness, dispersing cold for relieving pain is opened expectorant, detumescence.Control anemofrigid-damp arthralgia, paralysis due to windstroke, tetanus, wind syndrome of head, coldness and pain in the epigastrium, accumulation of phlegm in the hypochondrium, air parcel, cold-dysentery, sore throat, furuncle, scrofula.

Compatibility and incompatibility of drugs: all empty people, anemia of pregnant woman, hyperactivity of fire caused by deficiency of YIN and heat syndrome pain person avoid clothes, the careful usefulness of survivor.

Radix Aconiti has another name called Radix Aconiti " Medical Treasures of the Golden Chamber "

Base is former: be ranunculaceae plant Aconitum carmichjaelii Debx. (tuber of cultivation product).

Composition: contain 6 kinds of alkaloids: hypaconitine, aconitine, mesaconitine, talaisamine, chuan-wu base A and chuan-wu base B.Other says and contains hypaconitine in the tuber, aconitine, and mesaconitine, Ka Michalin etc., chuan-wu base B are exactly Ka Michalin.

Pharmacology: 1. to action of the heart: aconitine is to exsomatizing and the frog heart on the throne, just makes decreased heart rate (Ah taking off's product capable of blocking it) immediately owing to highly stimulated cardiac muscle, heart rate quickening suddenly, heart contractility is strengthened, occur the heart rate disorder very soon, heart contractility weakens, and final heart beating stops.Its therapeutic dose can make decreased heart rate to the people, pulse soft and a little less than, blood pressure edges down; Toxic dose can make the dog tachycardia, and property Fibrillation in chamber is fluttered.It is to action of the heart, part is owing to vagal influence, and main is direct effect to cardiac muscle, and (1) causes the effect of quivering: aconitine is poisoned and is very easily produced ventricular fibrillation, aconitine cause the effect of quivering, many at present instruments as the anti-arrhythmia of research.(2) cardiac stimulant effect: itself there is no cardiotonic aconitine, and is extremely strong to cardiac toxicity; And its hydrolyzate---the toxicity of aconine only is 1/2000-1/4000 of aconitine.Meaning tool cardiotonic is arranged, can resist the arrhythmia that aconitine causes at isolated frog heart; In recent years there is human to test in isolated heart (frog, Cavia porcellus), faint cardiotonic is only arranged through the aconitine solution of hydrolysis in 10 and a half hours.

2. to the influence of blood pressure blood vessel: aconitine can make blood pressure drops, and Chinese Aconitum carmichjaelii Debx. and river Radix Aconiti Lateralis Preparata (hot Radix Aconiti Lateralis Preparata) decoct can cause rapid and of short duration blood pressure lowering to anesthetized dog or cat.This moment, heart there is no significant change, and blood pressure lowering can be eliminated by a large amount of atropine or diphenhydramine.Show that with the peripheral resistance determinator RADIX ACONITILATERALIS PREPARATA decoct can cause that lower limb vascular significantly expands, still can expand coronary vasodilator (irrelevant to the blood pressure heart rate) in addition has meaning emergency treatment for reviving YANG soup (Radix Aconiti Lateralis Preparata, Camphora, Radix Ginseng, Moschus) that boosting is arranged.

3. antiinflammation and with adrenocortical relation: RADIX ACONITILATERALIS PREPARATA (Radix Aconiti Lateralis Preparata) decoct has a tangible antiinflammation through lumbar injection or oral PARA FORMALDEHYDE PRILLS(91,95) and Ovum Gallus domesticus album ankle joint are swollen.RADIX ACONITILATERALIS PREPARATA decoct oral no matter (0.2 gram/100 grams), subcutaneous or intramuscular injection all can significantly reduce content of ascorbic acid in the rat adrenal gland, and its effect is not blocked by pentobarbital sodium and chlorpromazine, but can part be blocked by cortisone.

4. to central nervous system's influence: 0.1-0.2 milligram/kilogram of aconitine, can destroy rat point defense-motion pole-climbing trained reflex, unconditioned reflex also is subjected to light damage, and each ammonia content of brain all sharply descends; Inject the rabbit ventriculus quartus with 0.002 microgram/kilogram, can cause the anesthesia phenomenon.

5. other effects: aconitine can suppress respiratory center, makes breathing slack-off; Excited earlier to the Mucocutaneous sensory nerve ending in part, to scratch where it itches, burn feeling continues with paralysis, but unconsciousness and reflexive cause that salivation is hyperfunction, and heating and intact animal's body temperature are reduced.

Toxicity: Aconitum carmichjaelii Debx. toxicity is extremely strong; because of kind; acquisition time; concoct, differences such as decocting time, the toxicity difference is very big; alkaloid can lose 81.3% in the concocting process; different regions Radix Aconiti Lateralis Preparata toxicity test can differ 8 times more than, does not have parallel relation between its total alkaloid content and toxicity intensity, and with acetyl content bigger relation is arranged.Tired hungry, hemorrhage animal toxicity can weaken, and sympathetic nervous system superfunction person easily poison.

Toxic dose: 0.1-3 liang of Radix Aconitis, 0.5-2 liang of Radix Aconiti Lateralis Preparatas, oral 0.2 milligram of aconitine.Poisoning symptom: sialorrhea, feel sick vomiting, diarrhoea, giddy, dim eyesight, dispute, extremity and whole body are numb, and pulse reduces, dyspnea, tetany, unconsciousness, gatism, blood pressure and body temperature descend, and premature ventricular beat is that premature ventricular beat or sinus rhythm accompany by the frequent premature ventricular beat of multi-source and antrum stops fighting.Zoopery proves that the ECG change when RADIX ACONITILATERALIS PREPARATA is poisoned is similar to aconitine, and a large amount of atropine are to the rabbit of RADIX ACONITILATERALIS PREPARATA poisoning, and the electrocardiogram of Cavia porcellus has this kind effect, but can not prevent animal dead, but has report can reduce mortality rate to the mice of aconite poisoning.Lignocaine can significantly reduce the mortality rate of animal because of aconite poisoning.Rhizoma Zingiberis Radix Glycyrrhizae and RADIX ACONITILATERALIS PREPARATA can make latter's toxicity reduce greatly with boiling, Flos Lonicerae in addition, and Semen phaseoli radiati, Cornu rhinocerotis also can detoxify.Aconitine is at the caused Fibrillation of isolated atria, procaine, and antihistaminic, the quinine fourth, heart Dean all can suppress it.

Nature and flavor: hot, heat, poisonous.

Gui Jing: 1. " key medicine is divided agent ", go into spleen, the gate of vitality's two warps.2. herbal brief points " the moon of fainting of starting with.Shaoyin channel.”

Function cures mainly: dispelling cold and dampness, the ailment said due to cold or exposure of loosing, wet warp, pain relieving.Control anemofrigid-damp arthralgia, severe and migratory arthralgia pain, spasm of the limbs, hemiplegia, wind syndrome of head headache, trusted subordinate's cold type of pain, carbuncle of yin nature toxic swelling.

Compatibility and incompatibility of drugs: the deficiency of YIN excess of YANG, heat symptom-complex pain and not being taken by pregnant women.

Radix Anisodi Acutanguli (" Chinese medicine shape property check differential method ")

Different name: BrachybotryS paridiformis, big Radix scopoliae sinensis, hill cigarette (" Yunnan Chinese herbal medicine "), wild tobacco (" Kunming medical herbs commonly used among the people ").

Base is former: be the root leaf or the seed of plant of Solanaceae Radix Anisodi Acutanguli.

Composition: the root of Radix Anisodi Acutanguli contains alkaloid more than 1%, and the overwhelming majority is hyoscyamine (being hyoscyamine) and hyoscine (scopolamine), multiple alkaloid such as Cuscohygrine.

Pharmacology: root contains multiple alkaloids such as hyoscyamine and Cuscohygrine, and the former effect is similar to atropine.The fluid extract of Radix Anisodi Acutanguli makes platycoria, salivation reduce, remove effects such as smooth muscle spasm, no maincenter sedation.

Cuscohygrine does not have physiologically active, past is not used always, is developed into red ancient bean Semen Armeniacae Amarum acid esters (promptly 701) recently, and the effect of Radix Anisodi Acutanguli fluid extract sample is also arranged, Canis familiaris L. or cat intramuscular injection are hypotensive effect for 10 milligrams/kilogram, and rabbit ear blood vessel after injecting is obviously expanded.Now on probation clinical, 50 milligrams/time of adult's intramuscular injection.

Toxicity: the mice median lethal dose(LD 50) (milligram/kilogram) of " 701 ": intravenous injection is 62, and lumbar injection is 300-400, irritates stomach and is about 3000, and intoxicating phenomenons such as stupor, astasia, platycoria can appear in 830 milligrams/kilogram of rabbit subcutaneous injections.Dosage increases to 1400 milligrams/kilogram, can cause death in 10 minutes, breathes when dead to stop prior to heart.Poisoning can appear for 300 milligrams/kilogram in cat skin injection down, and 500 milligrams/kilogram can cause death.30 milligrams/kilogram of anesthesia Canis familiaris L. intramuscular injection, the electrocardiogram no change.

Nature and flavor: " Yunnan Chinese herbal medicine " " pained fiber crops, temperature, severe toxicity.”

Function cures mainly: the analgesia.Control and have a stomach-ache fracture, rheumatalgia, traumatic injury.

Compatibility and incompatibility of drugs: heart disease, the person of having a weak heart avoid clothes.

Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) " traditional herbal medicine of science "

Base is former: be the tuber of ranunculaceae plant aconitum brachypodum etc.

Composition: the tuber that Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) is produced in the Zhaotong, Yunnan contains 5 kinds of alkaloids: aconitine, hypaconitine and bullatine B, penta plain and own element.The tuber that Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) is produced in Dongchuan, Yunnan contains 5 kinds of alkaloids: bullatine A, second element, third element, fourth element and heptan element.

Pharmacology: the salt pair white mice performance analgesic activity of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) first, second and fourth alkali, there is human Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) methine to test by hot plate method, its analgesia index only is 1/11 of a morphine, its analgesic effect is very undesirable, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) has the effect of approximate Folium Digitalis Purpureae sample to the frog heart, the cardiac dysfunction that it produced, atropine and quinine can be prevented it, the symptom of performance parasympathetic nervous excitement during poisoning.It is big to mouse toxicity to fall wooden club, irritates stomach with 100% decoct, and its lethal dose is equivalent to crude drug 0.08-0.3 gram/10 gram body weight.

Nature and flavor: " choosing of Yunnan Chinese herbal medicine ": " bitter fiber crops, wet, big poison ".

Function cures mainly: anti-inflammatory analgetic, expelling wind and removing dampness.Control traumatic injury and decrease, fracture, rheumatic ostalgia, toothache, sore swollen toxin, venom." Yunnan Chinese herbal medicine " " anti-inflammatory analgetic, expelling wind and removing dampness ".

Compatibility and incompatibility of drugs: severe toxicity is arranged,, should not take orally without the process of preparing Chinese medicine.Period in a medicine is avoided eating anything raw or cold, beans, beef and mutton.

Herba Asari " herbal classic "

Different name: Xiao Xin (" herbal classic "), Herba Ceratophylli Demeersi (" WU Pu Bencao "), few hot (" detailed outline "), Kingdonia uniflora, Jin Pencao (" the Chinese crude drug handbook), recluse join (Jiangsu).

Base is former: be the whole herb with root of aristolochiaceae plant Herba Asari or magnificent Herba Asari.

Composition: Herba Asari contains that volatile oil is about 3%, and main component of essential oil is a methyleugenol, and other has safrole β-pinene, Eucarvone, phenolic substance etc.

China's Herba Asari contains volatile oil 2.75%, 1.9%.Main Ingredients and Appearance is that methyleugenol (accounting for 50%) also has saishinone, pinene, Eucarvone, safrole, 1,8-cineole (accounting for 0.2%) etc. in the volatile oil.The mutation A.sicboldiivar.seoulensis Nakai of China's Herba Asari is similar with magnificent Herba Asari with A.sieboldii var cineoliferum volatile oil composition.

Pharmacology: 1. local anesthesia effect: magnificent Herba Asari water logging agent or pure preserved material (20-100%) can be blocked the sciatic conduction of impulse of the frog, in the test of Cavia porcellus skin mound, have infiltration anesthesia to render a service, but decoct are invalid.Herba Asari volatile oil still has topical anesthesia (rabbit corneal reflection) effect, and 50% Herba Asari tincture is made an appointment with half a minute after being applied to people's tongue, and the tip of the tongue promptly has hot creeping chill, after 1 minute feeling of numbness is arranged, later pain sensation complete obiteration, and the beginning recovers gradually through about 1 hour.Local action is contained that volatile oil is relevant with it, but stronger zest is arranged, and still discomfort is done the topical anesthesia agent.Report is arranged, and Herba Asari and other Chinese medicine share, and smear anesthesia with exodontia, obtain better effects.

2. analgesic, analgesic activity: 0.2-1.0 milliliters/kilograms of the arabic gum Emulsions of Herba Asari volatile oil are oral with rabbit, and the fervescence that normal and Wen Cifa are caused all has the reduction effect.To the heating that tetrahydrochysene-β-naphthylamines or typhoid fever, paratyphoid fever mixed vaccine cause, 0.5 milliliter/kilogram of oral volatile oil is some inhibitory action also.Same dosage has analgesic activity to rabbit (electricity irritation tooth marrow method), and intensity is similar to anodynine.

3. bacteriostasis: preliminary in vitro tests, Herba Asari be to Hemolytic streptococcus, dysentery bacterium, Bacillus typhi, so tubercule bacillus some inhibitory action is arranged, remain further research.

4. to the effect of blood pressure: magnificent Herba Asari leachate (0.125-0.25 gram/kilogram) intravenous injection, can reduce the blood pressure of anesthetized dog.Further analyze and point out; Basin grass Herba Asari volatile oil can make the anesthetized animal blood pressure drops, and decoct then makes increased blood pressure, and calls magnificent Herba Asari instant embrane and blood pressure are all had the effect of epinephrine sample.

5. toxicity and other effects: magnificent Herba Asari volatile oil is to the frog, mice, rabbit etc., just be excited phenomenon, then sink into palsy, voluntary movement and respiratory movement are gone down, the while areflexia, dead with respiratory paralysis eventually, breathing stops prior to heart beating, and myocardium smooth muscle is had direct repression.Alcohol extract on one's body rabbit, can antagonism the respiration inhibition that causes of morphine.To mouse stomach and intravenous injection, its median lethal dose(LD 50) is respectively 123.75 milligrams and 7.78 milligrams/10 grams.The toxicity of kakuol leachate is greater than water decoction.

Nature and flavor: hot, warm.

Function cures mainly: dispels the wind, and cold expelling, row water is had one's ideas straightened out.Control the cold wind headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatism paralysis.

Compatibility and incompatibility of drugs: deficiency of vital energy hyperhidrosis, the blood deficiency headache, clothes are avoided in coughs due to yin deficiency etc.

Gekko Swinhonis " detailed outline "

Different name: Gekko Swinhonis ， Sphenomorphus Yan (" elegant "), gecko, Gekko Swinhonis, wall palace (Tang Materia Medica) are warded off palace (Holy Benevolent Prescriptions), the pool, ground worm (" plucking unit side "), Gekko Swinhonis (" decoction pieces is newly joined ") is climbed Gekko Swinhonis (" Sichuan Chinese medicinal herbal ").

Base is former: for the Gekkonidae animal does not have all of web Gekko Swinhonis or other several Gekko Swinhonis.

Nature and flavor: " detailed outline " " salty, cold, slightly poisonous ".

Function cures mainly: dispel the wind arresting convulsion, eliminating stagnation, detoxifcation.Control paralysis due to windstroke, severe and migratory arthralgia pain, wind-phlegm infantile convulsion, scrofula, malignant boil.

Herba Saussureae Involueratae (" detailed outline is picked up any lost article from the road ")

Different name: Herba Saussureae Involueratae (" territory, northwest note "), snow Flos Nelumbinis (" detailed outline is picked up any lost article from the road "), big thumb flower (" Tian Bao book on Chinese herbal medicine is augmented in revision "), big wood flower (" Sichuan Chinese medicinal herbal ").

Base is former: be feverfew Saussurea laniceps, snow lotus of big bud flower (having another name called Saussurea involucrata), the wounded in the battle herb of Saussurea medusa Maxim. etc.

Nature and flavor: sweetness and bitterness, temperature (snow lotus of big bud is spent poisonous).

Compatibility and incompatibility of drugs: " Xinjiang Chinese herbal medicine handbook " is not taken by pregnant women.It is excessive that to cause the big fellow dripping.”

Rsdix Wisterinae Venustae (" mountain of papers Chinese herbal medicine ")

Base is former: the root of spending Chinese wistaria for leguminous plant in vain.

Nature and flavor: the bitter in the mouth suffering, hot in nature.Poisonous.

Function cures mainly: relieving the exterior syndrome by diaphoresis, remove the wind damp eliminating.Dispelling the wind and dampness pathogens pain, traumatic injury, cold, fever, headache nasal obstruction.Compatibility and incompatibility of drugs: the careful usefulness of weak and anemia of pregnant woman.

Function cures mainly: relieving the exterior syndrome by diaphoresis, remove the wind damp eliminating.Dispelling the wind and dampness pathogens pain, traumatic injury, cold, fever, headache nasal obstruction.

Compatibility and incompatibility of drugs: the careful usefulness of weak and anemia of pregnant woman.

Sanguis Draxonis (" Thunder God big gun moxibustion opinion ")

Different name: black horse Lin exhausts (" Thunder God big gun moxibustion opinion "), dragon's blood (Holy Benevolent Prescriptions), wooden Sanguis Draxonis (" the southern regions of the Yunnan Province book on Chinese herbal medicine ")

Base is former: be the resin in babassu kylin fruit and the trunk.

Composition: be a kind of resin ester (C ₆H ₅COCH ₂COOC ₈H ₉O) and dracoresinotannol (C ₄H ₅COOC ₈H ₉O) mixture contains 57-82% approximately, and other contains unbodied dracoalban, and is about 2.5%, and yellow dracoresene is about 14%, insoluble resin 0.3%, vegetalitas dregs 18.4%, phlobaphene 0.03%, ash 8.3%.

Pharmacology: antifungic action.Sanguis Draxonis water logging agent (1:2) has in various degree inhibitory action to various pathogens such as trichophyton, trichophyton gypseum, oidium schoenleiniis in vitro.

Nature and flavor: sweet salty, flat.Gui Jing: Liver Channel after one's own heart.

Function cures mainly: dissipating blood stasis analgesic therapy, hemostasia and promoting granulation.Control traumatic injury and lose, internal injury is become silted up bitterly; Continuous bleeding due to traumatic injury, scrofula, ecthyma, bursting does not conform to for a long time.

Compatibility and incompatibility of drugs: " Japan hanako materia medica " " it is good to get the Lithargyrum "; " all disorders of blood do not have alluvial person and needn't use " Bencao Jingshu ".”

Borneolum Syntheticum (" detailed outline ")

Base is former: be the processed goods of Dipterocarpaceae plant Borneolum Syntheticum resin, or Camphora, Lignum Pini Nodi wet goods chemical method, the synthetic product of being processed into.

Composition: this product is the crystallization that obtains from the resin of Borneolum Syntheticum and volatile oil, is to be close to pure dextro Borneolum Syntheticum.Contain multiple ter penoids in the resin of Borneolum Syntheticum and the volatile oil.Except that Borneolum Syntheticum, still contain Humuleno, β-elemene, sesquiterpenes such as caryophyllene, oleanolic acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, triterpenoids such as erythrodiol.These compositions, what are often sneaked in city's product Borneolum Syntheticum.

Pharmacology: its effect is similar to Camphora.It is very light to sensory nerve stimulation to be applied to the part, and some pain relieving and gentle antisepsis are arranged; At external (dull and stereotyped mixing method) higher concentration (0.5%) bacteriostasis is arranged; Can be used for neuralgia or antiinflammatory.Mucosa, subcutaneous tissue all easily absorb, and combine the back in vivo with glucuronic acid and get rid of external.

Nature and flavor: arduous, cold.

Gui Jing goes into the heart, lung meridian.

Function cures mainly: logical all keys, and the stagnated fire of loosing, removing nebula makes eye bright, reducing swelling and alleviating pain.Control the apoplexy locked mouth, calentura coma, infantile convulsion expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, conjunctivitis, enterobiasis." can cure mirror approximately " " controlling arthrodynia of extremities ".Lee fruit: " controlling osteodynia ".

Compatibility and incompatibility of drugs: the asthenia of qi and blood person avoids clothes, the careful clothes of anemia of pregnant woman.

Radix Sophorae Flavescentis (" herbal classic ")

Different name: bitter bone (" detailed outline "), river ginseng (" Guizhou side's medicine among the people collection "), cattle ginseng (" Hunan medicine will ").

Base is former: be the root of leguminous plant Radix Sophorae Flavescentis.

Composition: root contains multiple alkaloid: d-matrine, d-oxymatrine, sophoranl, 1-anagyrine, 1-methylcytisine, 1-baptifoline and sophocarpine.Also contain flavonoid: xanthohumol, isoxanthohumol, 3,4,5-three hydroxyls-7-methoxy-8-isoamylene radical chromocor, 8-isopentene group nimbecetin etc.

Pharmacology: 1. diuresis: Radix Sophorae Flavescentis decoct and wherein contained matrine give rabbit oral or injection, all can produce diuresis, and increasing that salinity discharges promptly arranged before the urine amount increases.

2. antipathogen effect: decoct is in test tube, and high concentration (1:100) has inhibitory action to tubercule bacillus.Decoct (8%), water logging agent (1:3) have in various degree inhibition external to some common skin fungus.Alcohol extractum still has an anti-trichomonal effect external, and intensity is weaker than Rhizoma Coptidis, and similar to Fructus Cnidii.

3. other effects: matrine is injected in rabbit, finds nervus centralis paralysis phenomenon, and spasm takes place simultaneously, whole then respiratory arrest and extremely.

Nature and flavor: bitter, cold.

Function cures mainly: heat clearing away, dampness, parasite killing.Control toxic-heat and blood stasis, discharging fresh blood stool, yellow cellulitis, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, the hemorrhoid complicated by anal fistula proctoptosis, skin itching, erosion of vulva pruritus due to damp pathogen is scalded.

Gui Jing goes into liver, kidney, small intestinal, large intestine channel.

Compatibility and incompatibility of drugs: the Deficiency and coldness of spleen and stomach person avoids clothes.

Unique, simple, easy to use, the instant effect of making of the advantage prescription of medicine of the present invention.

Medicament selection Semen Sinapis Albae of the present invention, Arisaema Cum Bile, Radix Aconiti Kusnezoffii, Radix Aconiti, Radix Anisodi Acutanguli and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) make up, and make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat rheumatism.In order to reach better therapeutic, medicine of the present invention also with Herba Asari, Gekko Swinhonis, Herba Saussureae Involueratae, Rsdix Wisterinae Venustae, Sanguis Draxonis, Borneolum Syntheticum and Radix Sophorae Flavescentis combination, play potentiation, can be according to patient's the concrete state of an illness, increase simply or its simply more than.Herba Asari has and dispels the wind in the side, cold expelling, and the effect that row water is had one's ideas straightened out, as " herbal classic ": " main cough with dyspnea, the headache brain is moving, hundred joint contractures, the rheumatism paralysis, dead flesh makes eye bright sharp nine orifices.”。" book on Chinese herbal medicine is dredged warp " cloud: " Herba Asari, the wind medicine also.The wind liter rises then uply, and suffering is then horizontal to be walked, and Wen Ze disperses, so main cough with dyspnea, the headache brain is moving, hundred joint contractures, rheumatic arthralgia, dead flesh.Lid numbness and dead flesh all be the sense water-damp from the earth, or double wind and cold become.The wind energy dehumidifying, temperature energy cold expelling, suffering can be had one's ideas straightened out, wind and cold wets disease also so treat as above ".According to modern clinical report: make 3% anesthesia liquid with dry Herba Asari through the volatile oil of ether extraction, be used for the local anesthesia effective percentage and reach 96.2%, see " a Chinese medicine dictionary Herba Asari piece of writing ".Herba Asari has only water logging agent or pure preserved material to have the fiber crops of infiltration effectiveness, so analgesic effect is good.Saussurea involucrata has the effect of removing cold tonifying YANG wind-damp dispelling in the side.As " detailed outline is picked up any lost article from the road ": " controlling all sympotoms caused by cold factors "." Xinjiang Chinese herbal medicine handbook cloud: " restore menstrual flow and invigorate blood circulation, bone and muscle strengthening promotes uterine contraction.Treating rheumatic arthritis." in the side Gekko Swinhonis have and dispel the wind, arresting convulsion, eliminating stagnation, Detoxication, treatment paralysis due to windstroke, severe and migratory arthralgia pain.As " detailed outline " cloud: " control paralysis due to windstroke, brothers' erectile problem, or severe and migratory arthralgia pain.”。" Sichuan Chinese medicinal herbal " cloud: " wind dispelling, removing blood stasis amasss enclosed mass, curing oncoma ".Sanguis Draxonis has diffusing silt analgesic therapy, hemostasia and promoting granulation in the side.Control traumatic injury and decrease folding, the internal injury pain of becoming silted up, as " detailed outline " cloud: " interchannel Liu Shi cloud, Sanguis Draxonis dehematize pain is for the panacea with blood is also.Olibanum, Myrrha, though main disorders of blood and is doublely gone into edema caused by disorder of QI, this then specially goes into blood system person is also "." book on Chinese herbal medicine is dredged warp " cloud: " black horse Lin exhausts, sweet main the benefit, and salty master disappears, the key medicine of loose congestion, tissue regeneration promoting blood ... the naphthalene master of Soviet Union sudden attack of pain in the chest and abdomen, Lee Xun cure the wound to roll over it and beat damage, all pain, and vim and vigour are stirred thorn, and interior blood trouble is poly-, really with this ear." this prescription controls the anemofrigid-damp arthralgia Sanguis Draxonis, also abides by the traditional Chinese medical science thousands of years " control wind and control blood earlier, the blood sector-style is from going out " and the reason of " pain person is obstructed, and logical person is not bitterly ".Borneolum Syntheticum has the effect of reducing swelling and alleviating pain in the side, as " can cure mirror approximately " cloud: " controlling arthrodynia of extremities ".Li Guoyun " controls osteodynia ", " Borneolum Syntheticum to the marrow, the wind pain should be used it the bone marrow person "." Bencao Jingshu " cloud: " Borneolum Syntheticum, its perfume (or spice) are the hat of hundred medicines.All fragrance is the person very, and its property must be warm, and Lee Xun says temperature, and You Su speech heat is.The strong flavor Da Xin of gas virtue, the yang aspect of yang rises also and looses also.Property is apt to away scurry and is had one's ideas straightened out, and does not have toward not reaching, and the gas of fragrance can be warded off all evilnesses.Hot property, all rheumatism of loosing.”。

The manufacture method of medicine of the present invention: getting pure dried medical material (nothing is gone mouldy, no worm-eaten), is superfine end altogether.Can be made into 20 bags in every bag of every box of 25g.This product is a medicine for external use, and is rigorous for oral administration.

The using method of medicine of the present invention: use eliminating cold for resuscitation water in right amount this product furnishing thick paste, subsides and joint or myalgia sore spot, generally each sore place pastes a card.The each subsides 40 minutes, the external plastics make things convenient on the pkt. flap, anti-sliding stop, medication in 7 days 1 time.Can stick a plurality of positions simultaneously at every turn.Each 7 days at interval.3 medications are a course of treatment, each 7 days at interval.

Points for attention: the breakage of festering, injure allergy sufferers outward and can not paste usefulness, paste the painful person of back localized heat, belong to normal phenomenon.If painful very person can take off in advance, forbid to take orally.

Toxicity research: this bone strengthening that dispels the wind is invigorated blood circulation to loose and is belonged to medicine for external use, form by Semen Sinapis Albae, Rhizoma Arisaematis, Radix Aconiti, Radix Aconiti Kusnezoffii, Herba Asari, Gekko Swinhonis, Radix Anisodi Acutanguli, Rsdix Wisterinae Venustae, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Herba Saussureae Involueratae, Sanguis Draxonis, Borneolum Syntheticum, Radix Sophorae Flavescentis etc., above medicine is a poisonous drugs, forbids to take orally.External does not have obvious adverse reaction, and all patients all have heat to dislike, and show as the burning pain sense individually, but do not influence treatment, and ointment is taken off in back 2 days and can be disappeared, and anaphylaxis is arranged, drug withdrawal immediately, and the antianaphylactic treatment of suiting the medicine to the illness gets final product.Minor Ying Jinyong.

Drug effect: chase after wind dispelling cold and dehumidification, bone and muscle strengthening collateral dredging, phlegm reduction of blood circulation promoting pain relieving.Cure mainly: by wet rheumatalgia, the arthralgia that causes of wind and cold, neuralgia, be confined in childbirth puerperal catch cold, scapulohumeral periarthritis, the functional rehabilitation of pain of neck, shoulder, waist and leg, old sprain and contuse, hyperosteogeny etc.Routine patient's observation surplus clinical 6 years ten thousand, the pain relief cure rate reaches 85%, effective percentage 95%.This product biggest advantage is convenient, simple, instant effect, and maximum defective is a large-area applications for a long time.

Pharmacological property and clinical verification according to above medicine, be used for arthritis, rheumatoid arthritis, tetanic property vertebra class bones and muscles pain numbness, sterile bone necrosis, traumatic injury, intervertebral disk hernia, cervical vertebra, knee joint and each position hyperosteogeny, the neck-shoulder pain, lumbago and leg pain that the women is confined in childbirth and catches cold and cause, rheumatisms such as cool fiber crops, a drug promptly has remarkable result, through clinical cure rate 85% for many years, effective percentage 95%.

Concrete embodiment

Proportioning, making and the use of embodiment 1 medicine

Get not have and go mouldy, pure dried medical material Semen Sinapis Albae 80 grams of no worm-eaten, Arisaema Cum Bile 40 grams, Radix Aconiti Kusnezoffii 50 grams, Radix Aconiti 6 grams, Herba Asari 10 grams, Gekko Swinhonis 10 grams, Radix Anisodi Acutanguli 50 grams, Herba Saussureae Involueratae 20 grams, Rsdix Wisterinae Venustae 20 grams, Sanguis Draxonis 5 grams, Borneolum Syntheticum 5 grams, Radix Sophorae Flavescentis 40 grams and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 50 grams are superfine end altogether.

With eliminating cold for resuscitation water in right amount this product furnishing thick paste, subsides and joint or myalgia sore spot, generally each sore place pastes a card.The each subsides 40 minutes, external plastics make things convenient for anti-sliding stop on the pkt. flap.

The clinical observation of embodiment 2 treatment of arthritis of the present invention

Accept patient's 420 examples for medical treatment, cure 362 people in a course of treatment, symptom is significantly improved 41 people, average effectiveness level 96%.

Symptom: walking can pain, standing also can pain, and especially during stair activity, pain gets more severe.Hip joint, knee endoprosthesis and thumb joint.Arthritic feature is the surface skin swelling, heat, red and joint motions are restricted in joint, and pain again.

Prescription: Semen Sinapis Albae 60 grams, Arisaema Cum Bile 20 grams, Radix Aconiti Kusnezoffii 30 grams, Radix Aconiti 40 grams, Radix Anisodi Acutanguli 30 grams, Radix Aconiti Brachypodi Radix Aconiti Szechenyiani 30 grams.Making and use are with embodiment 1.

Model case: open * *, man 49 years old, right knee joint suffers from arthritis outbreak swelling is arranged for many years, and the pain severity of upward going downstairs uses this prescription to stick a course of treatment, and right knee joint takes a turn for the better and subsides a swelling, and goes up downstairs not pain, freedom of movement.

Embodiment 3 the present invention treat the clinical observation of rheumatic arthritis

Accept patient's 320 examples for medical treatment, in a course of treatment, cure 272 people, effective 32 people, average effectiveness level 95%.

Symptom: big joint such as knee joint, ankle, elbow, wrist, pain is migration, can invade a plurality of joints simultaneously.

Prescription: Semen Sinapis Albae 100 grams, Arisaema Cum Bile 60 grams, Radix Aconiti Kusnezoffii 70 grams, Radix Aconiti 80 grams, Radix Anisodi Acutanguli 70 grams, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 70 grams, Herba Asari 30 grams, Herba Saussureae Involueratae 30 grams, Rsdix Wisterinae Venustae 40 grams, Borneolum Syntheticum 20 grams, Radix Sophorae Flavescentis 60 grams.Making and use are with embodiment 1.

Model case: Lee * *, woman 29 years old, ankle joint pain, swollen slightly, walk for a long time that pain more increases the weight of, at ordinary times also can pain.Stick and originally want a course of treatment, detumescence, action pain is eliminated.

Embodiment 3 the present invention treat the clinical observation of rheumatoid arthritis

Accept patient's 1320 examples for medical treatment, in a course of treatment, cure 924 people, effective 330 people, average effectiveness level 95%.

Symptom: arthralgia, pain, swelling, dysfunction, being that symmetry suffers from is its feature.Their early stage sees that finger, the palm, toes, toe joint ache earlier more, plays ankylosis morning, and it is unable particularly to clench fist, and is developed to wrist, ankle, elbow, knee joint, shoulder, hip joint then.

Prescription: Semen Sinapis Albae 70 grams, Arisaema Cum Bile 50 grams, Radix Aconiti Kusnezoffii 60 grams, Radix Aconiti 70 grams, Radix Anisodi Acutanguli 40 grams, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30 grams; Herba Asari 20 grams, Gekko Swinhonis 50 grams, Rsdix Wisterinae Venustae 20 grams, Sanguis Draxonis 10 grams, Borneolum Syntheticum 5 grams.Making and use are with embodiment 1.

Model case: Xiao *, woman 56 years old plays ankylosis morning, and it is unable particularly to clench fist, and elbow joint is the semiflexion shape more and can not stretches, and uses this plaster to apply a course of treatment, and can clench fist not stiff in the joint, the elbow joint tensible.

Embodiment 4 the present invention treat the clinical observation of ankylosing spondylitis

Accept patient's 620 examples for medical treatment, in a course of treatment, cure 552 people, effective 37 people, average effectiveness level 95%.

Symptom: sacrum bone and lumbar vertebra, full vertebra is got involved from bottom to up.

Prescription: Semen Sinapis Albae 100 grams, Arisaema Cum Bile 20 grams, Radix Aconiti Kusnezoffii 50 grams, Radix Aconiti 60 grams and Radix Anisodi Acutanguli 70 grams, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 60 grams; Herba Saussureae Involueratae 30 grams, Rsdix Wisterinae Venustae 10 grams, Sanguis Draxonis 15 grams, Borneolum Syntheticum 15 grams, Radix Sophorae Flavescentis 60 grams.Making and use are with embodiment 1.

Model case: Lee * *, man 21 years old, weak, low grade fever, loss of appetite, weight loss, spinal pain, stiff sense even movable function are limited, and rest can not be alleviated.Stick course of treatment of this medicine, remission is cured, and low grade fever goes down, and spinal pain disappears, and stiff sense disappears.

Embodiment 5 the present invention treat the clinical observation of sterile bone necrosis

Accept patient's 62 examples for medical treatment, in a course of treatment, cure 50 people, effective 8 people, average effectiveness level 94%.

Symptom: osteonecrosis is exactly that some paathogenic factor makes bone structure destruction, osseous tissue nutrition interruption, osteocyte death, and bone trabecula destroys, and osteonecrosis promptly takes place.Necrosis takes place under aseptic condition, so claim bland necrosis.The femoral head position taking place claim aseptic necrosis of femoral head, is called for short femur head necrosis.Osteonecrosis can occur in a lot of positions of human body, and the femur head necrosis morbidity is the most common, special physiological function and the structure of this and femoral head is closely related, hip joint is a spherical joint maximum in the human body six big joints, its eccentric carrying, stressed complexity, range of activity are wide, stress concentration is so femoral head easily necroses.

Prescription: Semen Sinapis Albae 80 grams, Arisaema Cum Bile 30 grams, Radix Aconiti Kusnezoffii 40 grams, Radix Aconiti 50 grams and Radix Anisodi Acutanguli 60 grams, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40 grams; Herba Asari 20 grams, Gekko Swinhonis 25 grams, Herba Saussureae Involueratae 25 grams, Rsdix Wisterinae Venustae 30 grams, Sanguis Draxonis 5 grams, Borneolum Syntheticum 10 grams, Radix Sophorae Flavescentis 30 grams.Making and use are with embodiment 1.

Model case: grandson * *, woman 39 years old, femur head necrosis sticks this medicine after course of treatment, and through check, femur head necrosis is cured.

Embodiment 6 the present invention treat the clinical observation of traumatic injury

Accept patient's 142 examples for medical treatment, cure 130 people in one to two course of treatment, symptom is significantly improved 9 people, average effectiveness level 98%.

Prescription: Semen Sinapis Albae 80 grams, Arisaema Cum Bile 40 grams, Radix Aconiti Kusnezoffii 50 grams, Radix Aconiti 60 grams and Radix Anisodi Acutanguli 50 grams, Herba Asari 10 grams, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 50 grams, Gekko Swinhonis 10 grams, Herba Saussureae Involueratae 10 grams, Rsdix Wisterinae Venustae 20 grams, Radix Sophorae Flavescentis 40 grams.Making and use are with embodiment 1.

Model case: solemn * *, man 26 years old falls down by bike, and the right arm fracture of ossiculum sticks two courses of treatment of this medicine, the little knitting of the right arm of fracture.

Claims

1. medicine for the treatment of rheumatism is characterized in that it mainly is made up of following parts by weight raw material: 3-7 parts of 6-10 parts of Semen Sinapis Albaes, 2-6 parts of Arisaema Cum Bile, 3-7 parts of Radix Aconiti Kusnezoffii, 4-8 parts of Radix Aconiti, 3-7 parts of Radix Anisodi Acutangulis and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s.

2. the described a kind of medicine for the treatment of rheumatism of claim 1, wherein raw material also has: 2-6 parts of 0.1-3 parts of Herba Asari, 0.1-3 parts of Gekko Swinhoniss, 0.1-3 parts of Herba Saussureae Involuerataes, 0.1-4 parts of Rsdix Wisterinae Venustaes, 0.1-2 parts of Sanguis Draxonis, 0.1-2 parts of Borneolum Syntheticums and Radix Sophorae Flavescentiss.

3. the described a kind of medicine for the treatment of rheumatism of claim 1, wherein the consumption of each component is: 5 parts of 8 parts of Semen Sinapis Albaes, 4 parts of Arisaema Cum Bile, 5 parts of Radix Aconiti Kusnezoffii, 6 parts of Radix Aconiti, 5 parts of Radix Anisodi Acutangulis and Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s.

4. the described a kind of medicine for the treatment of rheumatism of claim 2, wherein raw material is: 4 parts of 6-10 parts of Semen Sinapis Albaes, 2-6 parts of Arisaema Cum Bile, 3-7 parts of Radix Aconiti Kusnezoffii, 4-8 parts of Radix Aconiti, 3-7 parts of Radix Anisodi Acutangulis, 3-7 parts of Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani)s, 1 part of Herba Asari, 1 part of Gekko Swinhonis, 1 part of Herba Saussureae Involueratae, 2 parts of Rsdix Wisterinae Venustaes, 0.5 part of Sanguis Draxonis, 0.5 part of Borneolum Syntheticum and Radix Sophorae Flavescentiss.