CN105267501A - Traditional Chinese medicine composition for treating poisonous snake bites - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating poisonous snake bites, comprising following materials by weight: all-grass of Madras Grangea 7-9 parts, Radix Angelicae Dahuricae 10-14 parts, distinct wildginger herb 5-7 parts, adder tongue herb 9-13 parts, herb of Pimpinella diversifolia 4-6 parts, root of Saponaria officinals 4-6 parts, Herb of climbing groundsel 9-11 parts, herb of Japanese wormwood 7-9 parts, root and all-grass of Picris hieracioides 5-7 parts, herb of Chinese Lobelia 7-9 parts, Rhizoma Paridis Chinensis 4-6 parts, creeping Pothos stem and leaf 4-6 parts, bark of Rhus chinensis 4-6 parts, and leaf of seven-leaved chaste tree 5-7 parts. The traditional Chinese medicine composition mainly used for treating poisonous snake bites.

Description

A kind of Chinese medicine composition for the treatment of venom

Technical field

The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of venom.

Background technology

The common poisonous snake of venom has Agkistrodon halys, Naja, Agkistrodon, Bungarus fasciatus and Trimeresurus stejnegeri etc.Snake venom mainly contains neurotoxin, heart and brain toxin, blood coagulation toxin, hemorrhagin toxin and enzyme toxin etc., venom enter in body can cause bleeding, haemolysis, cardiac damage, interfering energy metabolism and cause paralysis of respiratory muscle and Central respiration repression.Many because accidentally being entered in body poisoning caused by people by toxin after venom.

Clinical manifestation: (1) bite topical manifestations indentation as visible in wound, local swelling, causalgia unbearably, wounds streamed blood is more than, also has regional nodes's inflammation, lymphangitis etc. in addition.(2) blood circulation poisoning manifestations is as hemorrhage in whole body many places, epistaxis, spit blood, have blood in stool, hematuria, jaundice, cardiac arrhythmia and oliguria, anuria etc., severe patient can be dead because of circulatory failure and acute renal failure.(3) Nervous toxicity symptom is as headache and dizzy, drowsiness, sialorrhea, nausea and vomiting, dysphagia, hoarseness, slurred speech, audition, visual disorder, gatism and heating, shivers, and severe patient can have quadriplegia, paralysis of respiratory muscle, tic, stupor etc.

Plant for clinical antivenom tablet existing more than ten at present, first will understand fully that tablet used is effective to which kind of poisonous snake during use, be secondly that medication is wanted early, dosage wants large, and the course for the treatment of will be grown.Finally, the auxiliary treatment of other Chinese and western medicine must be adopted targetedly.What use the widest clinically is nantong sheyao (also known as jidesheng sheyao tablets), should take 20 immediately, take 10 later every 6 hours, till lasting till that poisoning symptom obviously alleviates after wound.Simultaneously by tablet warm water furnishing pasty state, be coated in surrounding and the swollen swollen 3-4 centimetre place, upper end of limbs of wound, Guangzhou antivenom tablet (He Xiaosheng antivenom tablet) curative effect is also better, and take 5 immediately after wound, within later every 3 hours, take 5, serious symptom person's dose doubles.In addition, Shanghai antivenom tablet cures mainly Agkistrodon haly s bite, and the full antivenom tablet of Serpentis three cures mainly Bungarus fasciatus and Induced By Coral Snake Bite.

Chinese herbal folk: available fresh Herba Lobeliae Chinensis (herb) 30-60 gram, gets its juice and takes orally, have removing toxic substances and the effect of diuresis toxin expelling after mashing.Also can with fresh bird Chinese tallow tree tender shoots 30 grams, mash extracting juice and take orally, medicinal residues external application, can prevent snake venom to make a psychological attack.

Serum treatment: antivenin has certain curative effect to venom, monovalent serum curative effect can up to 90%, but polyvalent serum curative effect is only 50%.Successful serum on probation has agkistrodon halys antivenin, Naja antivenin, Agkistrodon Acutus antivenin and Bungarus Multicinctus antivenin etc. at present, and what have is refined into powder, is convenient to preserve.First skin anaphylactic test should be made, negative patient injectable before using antivenin.

Whole body supporting treatment: in a few days after venom, the state of an illness is heavier, poisoning symptom has obviously, and often with Electrolyte imbalance in various degree and shock, severe patient there will be respiratory failure, heart failure, acute renal failure, hemolytic anemia.The function of thus positive whole body therapeutic and correction main organs is important.Should give blood transfusion and fluid infusion in time when blood pressure is low, shock is treated, and gives to breathe agent and oxygen uptake, carry out complementary breathing if desired during shallow breathing.The application of adrenocortical hormone and antihistaminic class medicine, has certain effect to neutralizing a toxin and alleviating signs of toxicity.Whole body anti-infectives is important to the necrosis preventing and treating local organization, and regular injection TAT is to prevent tetanic generation.

Summary of the invention

The object of the invention is to provide a kind of prescription for the treatment of venom, for treatment venom provides a kind of new Chinese medicine composition.

Technical scheme of the present invention is:

Treat a Chinese medicine composition for venom, be made up of the raw material of following weight portion:

Tian Bianju 7-9 part, Radix Angelicae Dahuricae 10-14 part, Herba Asari insignis 5-7 part, Herba Ophioglossi 9-13 part, August white 4-6 part, Saponaria officinalis 4-6 part, Herba Senecionis Scandentis 9-11 part, flush Artemisia 7-9 part, hair Radix Bupleuri 5-7 part, Herba Lobeliae Chinensis 7-9 part, Rhizoma Paridis 4-6 part, Caulis et Folium Pothi Repentis 4-6 part, Galla Chinensis bark 4-6 part, seven leaf Folium Viticis Negundo 5-7 parts.

Preferably, be made up of the raw material of following weight portion:

Tian Bianju 8 parts, the Radix Angelicae Dahuricae 12 parts, Herba Asari insignis 6 parts, Herba Ophioglossi 11 parts, white 5 parts of August, Saponaria officinalis 5 parts, Herba Senecionis Scandentis 10 parts, flush Artemisia 8 parts, hair Radix Bupleuri 6 parts, Herba Lobeliae Chinensis 8 parts, Rhizoma Paridis 5 parts, Caulis et Folium Pothi Repentis 5 parts, 5 parts, Galla Chinensis bark, seven leaf Folium Viticis Negundos 6 parts.

By said ratio, Chinese medicine powder is broken into powder, both oral administration, also can external application, time for oral administration, by the pisiformis ball of general for powder water one-tenth, oral 15 at every turn (state of an illness is severe one 200 comparatively), external is determined according to swelling scope, and fundamental quantity is 150g, applies powder in affected part.

Tian Bianju, has another name called Herba Kalimeridis, red stalk dish, Aster indicus, Tian Bianju, purple chrysanthemum, crab Qi head grass etc., belongs to Compositae Herba Kalimeridis and belong to herbaceos perennial.Tian Bianju has cooling blood for hemostasis, clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling.Concocting method: get crude drug, removing impurity, cleans, softens, cutting, dry.

The Radix Angelicae Dahuricae, perennial tall and big draft, have dispel the wind, dampness, detumescence, pain relieving, refreshment effect.Concocting method: pick decontamination, washes, and soaks, pulls out and run through, slightly shine to crust without soapy feeling time, then after moistening, chip drying.

Herba Asari insignis, has another name called arrowhead leaf Herba Asari, has effect of expelling wind and cold, pain relieving, promoting blood circulation and detoxication.Concocting method: pick decontamination, washes, and dries for subsequent use.

Herba Ophioglossi, another name Sinomenium acutum, Serpentis sting son, have the effect of heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, heart tonifying, cure mainly pain swollen, venom, scald, traumatic injury etc.Concocting method: removing impurity, cutting, dries in the shade.

August is white, has another name called bitter father's dish, Herba pimpinellae diversifoliae, spades are first-class, be the herb of the different leaf Pimpinella anisum Linn. of samphire, have effect of hemostasis, removing toxic substances, refreshment, diuretic.Concocting method: removing impurity, cutting, dries in the shade.

Saponaria officinalis, Latin literary fame: Saponariaofficinalis. Caryophyllaceae, Soapwort perennial herb, the effect of there is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling.Concocting method: all herbal medicine, picks decontamination, cutting, dries for subsequent use.

The effects such as Herba Senecionis Scandentis, has another name called Herba Hieracii Umbellati, Herba Senecionis Scandentis, Herba Sidae Rhombifoliae, Kowloon light, nine ridge light, be a kind of Chinese herbal medicine, have heat-clearing and toxic substances removing, improving eyesight, antipruritic.Concocting method: removing impurity, cutting, dries in the shade.

Flush Artemisia, has another name called Herba Artemisiae Japonicae, Compositae mugwort, have heat clearing away, detoxify, relieve summer heat, dry, stop blooding, antiinflammatory, dissipating blood stasis effect.Concocting method: clean, removes impurity, dries.

Hair Radix Bupleuri, another name rifle cutter dish, hair Radix Rumicis Crispi.Medicinal is root and the herb of feverfew Fols Picridis fuscipilosae (PicrishieracioidesL.).There is effect of heat-clearing and toxic substances removing, dissipating blood stasis, diuresis.Concocting method: summer and autumn gathers, cleans, dries.

Herba Lobeliae Chinensis, has another name called Herba Lobeliae Chinensis, suddenly separates rope, edible kernel of melon seeds grass, Herba Hedyotidis Diffusae, half ray flower, narcissus flowers and plants, the young grass of sickle etc., have effect of heat-clearing and toxic substances removing, inducing diuresis to remove edema.Concocting method: removing impurity, clean, cutting, dries.Concocting method: removing impurity, clean, cutting, dries.

Rhizoma Paridis is the plant of Liliaceae Paris Linnaeus(Paris L.).Another name Rhizoma Paridis, Chi stop, and heavy platform root, wholely to stop, and Rhizoma Paridis, heavy platform grass, white Radix Kansui, RHIZOMA PARIDIS, worm beach wormwood, nine road hoops, Aicis galericulata worm, branch fresh idea, Calanthe davidii Franhc., Carnis Rapanae thomasianae seven, lamp-stand seven, Omoto Nipponlily Rhizome, spiral shell top Radix Notoginseng, Herba Senecionis Chrysanthemoidis, has another name called Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae).There is effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Concocting method: removing impurity, cleans, runs through, shave, dry.

Caulis et Folium Pothi Repentis, medical material name.The property of medicine is trembled with fear, and has bone-setting pain stopping, removing toxic substances and promoting subsidence of swelling, effect of improving acuity of vision and removing nebula.Concocting method, root bark and root are used as medicine, and Xia Qiu gathers.

Galla Chinensis bark, Galla Chinensis is set, original name: Fructus rhois chinensis, another name: Galla Chinensis tree, five times of bavins, Galla Chinensis, mountain Firmiana platanifolia (Linn. f.) Marsili, wooden Galla Chinensis, black Folium Persicae, Wu Yanpao, chokedamp Fructus Persicae, ursolic acid Fructus Persicae, red-leaf peach, salt tree root, native Ailanthus altissima, Chinese lantern plant head, red salt fruit, gall nut bavin, Chinese Nut-gall, skin willow, salt skin, hydrochloric acid in vain, Latin literary fame: RhuschinensisMill. Anacardiaceae, Rhus dungarunga or shrub shape.Galla Chinensis bark has effect of heat-clearing and toxic substances removing, antalgesic-antipruritic.Concocting method: use tree root skin, decontamination, dries for subsequent use.

Seven leaf Folium Viticis Negundos, the leaf of plant five-leaved chaste tree, has heat radiation of inducing sweat, effect of removing dampness for regulating stomach, killing parasites for relieving itching.Concocting method: get tender leaf, decontamination, dries in the shade for subsequent use.

The present invention compared with prior art tool has the following advantages:

Heat-clearing and toxic substances removing, detumescencing diuresis, hemostasis and pain-relieving, this side, from Qing Dynasty's initial stage, is handed down from age to age, and is used for the treatment of effective proved recipe of venom, evident in efficacy, takes the course of its own, sees special effect repeatly.Be this locality and the first-selected medication for the treatment of snakebite in the neighbourhood, and do not find other toxic and side effects.

Detailed description of the invention

Treat a Chinese medicine composition for snake venom, be made up of the raw material of following weight portion:

Tian Bianju 7-9 part, Radix Angelicae Dahuricae 10-14 part, Herba Asari insignis 5-7 part, Herba Ophioglossi 9-13 part, August white 4-6 part, Saponaria officinalis 4-6 part, Herba Senecionis Scandentis 9-11 part, flush Artemisia 7-9 part, hair Radix Bupleuri 5-7 part, Herba Lobeliae Chinensis 7-9 part, Rhizoma Paridis 4-6 part, Caulis et Folium Pothi Repentis 4-6 part, Galla Chinensis bark 4-6 part, seven leaf Folium Viticis Negundo 5-7 parts.

Above-mentioned Chinese medicine powder is broken into powder, the pisiformis ball of the general one-tenth of water, oral 15 at every turn (state of an illness is severe one 200 comparatively), external is determined according to swelling scope, and fundamental quantity is 150g.

Embodiment 1

Tian Bianju 7 parts, the Radix Angelicae Dahuricae 14 parts, Herba Asari insignis 5 parts, Herba Ophioglossi 13 parts, white 4 parts of August, Saponaria officinalis 6 parts, Herba Senecionis Scandentis 9 parts, flush Artemisia 9 parts, hair Radix Bupleuri 7 parts, Herba Lobeliae Chinensis 7 parts, Rhizoma Paridis 4 parts, Caulis et Folium Pothi Repentis 4 parts, 4 parts, Galla Chinensis bark, seven leaf Folium Viticis Negundos 7 parts.

Embodiment 2

Tian Bianju 9 parts, the Radix Angelicae Dahuricae 10 parts, Herba Asari insignis 7 parts, Herba Ophioglossi 9 parts, white 6 parts of August, Saponaria officinalis 4 parts, Herba Senecionis Scandentis 11 parts, flush Artemisia 7 parts, hair Radix Bupleuri 5 parts, Herba Lobeliae Chinensis 9 parts, Rhizoma Paridis 6 parts, Caulis et Folium Pothi Repentis 6 parts, 6 parts, Galla Chinensis bark, seven leaf Folium Viticis Negundos 5 parts.

Embodiment 3

Tian Bianju 8 parts, the Radix Angelicae Dahuricae 12 parts, Herba Asari insignis 6 parts, Herba Ophioglossi 11 parts, white 5 parts of August, Saponaria officinalis 5 parts, Herba Senecionis Scandentis 10 parts, flush Artemisia 8 parts, hair Radix Bupleuri 6 parts, Herba Lobeliae Chinensis 8 parts, Rhizoma Paridis 5 parts, Caulis et Folium Pothi Repentis 5 parts, 5 parts, Galla Chinensis bark, seven leaf Folium Viticis Negundos 6 parts.

Pharmacological action:

The Radix Angelicae Dahuricae:

Antiinflammatory action: the mouse stomach Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct (the suitable crude drug lg of lg) 4g/kg, obviously can suppress the inflammation (P<0.01) of dimethylbenzene induced mice ear.

Antipyretic effect: the hot animal model of height caused in White Rabbit back with peptone subcutaneous injection, the 1g Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct 15g/kg, have obvious refrigeration function.The mouse stomach Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct 8g/kg, obviously reduce the mouse writhing number of times caused by lumbar injection 1% acetic acid (0.l/kg), and effect is similar with aminophenazone 8 meters of g/kg, P<0.001.Woolfe-Macdonald method is tested, the front threshold of pain of administration person within 30 minutes, and gavage awards the Radix Angelicae Dahuricae or Radix angelicae dahuricae 8g/kg, after administration 60 minutes, and the Radix Angelicae Dahuricae and the anti-Radix Angelicae Dahuricae significantly improve pain threshold, compare P<0.001 and 0.01 with normal saline group.

Spasmolysis: the bergapton contained by this product, xanthotoxin, isoimperatorin second have obvious spasmolysis to rabbit ileum.Isoimperatorin can also increase the contractility of rabbit uterus and the tonicity of Lumbricus flesh.Scopoletin has spasmolysis at body or isolated rat uterus spasm caused by estrogen or barium chloride, and its ED50 is 0.09 meter of g/kg.

To cardiovascular effect: the isoimperatorin contained by this product and baelfruit element have the effect of blood pressure lowering to cat, 50 meters of g/kg reduce arterial pressure 50%, and it is 1.5 hours that effect is held time.The time lengthening 5-10 that the copolymer of isoimperatorin and N-vinylpyrrolidone can make cat arterial pressure reduce doubly.The contractility of isolated frog heart can also be reduced.

Antibacterial action: Radix Angelicae Dahuricae decoct all has inhibitory action to escherichia coli, dysentery bacterium, Bacillus proteus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, Bacillus tuberculosis etc.Oxypeucedannin in vitro tests contained by this product has antibacterial action to 11 kinds of bacterial strains; Imperatorin also has antibacterial action xanthotoxin; Be 100 meters of cg/ rice l to the rice IC of Bacillus tuberculosis H37RV.Water logging agent also has certain inhibitory action to pathomycetes such as Microsporon audouinis.

Photosensitization: the bergapten contained by this product, xanthotoxin, isoimperatorin the second grade furocoumarin compound are optical active substance, after they enter body, once be subject to daylight or ultraviolet radiation, then can make exposure place skin generation solar dermatitis, redness occurs, pigment increases, plain skin thickens.Photosensitive activity is the strongest with xanthotoxin, and bergapten takes second place, and isoimperatorin second is more weak.Light sensitive active ingredient can be used to treat vitiligo.Isoimperatorin is the psoriatic effective ingredient for the treatment of, and clinical erythema dose measures to be proved effectively.

Antitumaous effect: isoimperatorin and there is the cytotoxicity to Hela cell from angelicin.The ED50100 μ g/ rice l of isoimperatorin.

Radiation resistance: Radix Angelicae Dahuricae methanolic extract 1g/kg, in roentgen radiation x first 5 minutes lumbar injections, has protective action to mouse skin infringement.

Other effects: Radix Angelicae Dahuricae poison has excitation to animal oblongata vasomotor center, respiratory center, vagus nerve and spinal cord in a small amount, and blood pressure can be made to increase, and pulse is slack-off, exaggerated respiration, and sialorrhea can be caused to vomit, large scape uses can cause tatanic intermittent cramp, continues with general paralysis.

Herba Ophioglossi:

To neural effect:

1.1 analgesic activities, in hot plate method in mice and the test of rabbit photo-thermal stimulus method, all prove that sinomenine has the analgesic activity of affirmative.Intracerebral injection produces the dosage needed for analgesic activity, is equivalent to 1/2000 of lumbar injection, illustrates that its analgesic activity position is central nervous system; Share generation synergism with nalorphine, continuous application can produce toleration, but comparatively morphine is slow, and without cross tolerance between morphine; Continuous application, without additive, illustrates that its analgesia principle is different from m orphine.

1.2 sedation sinomenines can obviously reduce spontaneous activity in mice and passive activity, have no significant effect the barbiturates length of one's sleep; The convulsant threshold of strychnine to mice can be reduced, but can not pentylenetetrazole convulsion be resisted.Dog, the oral sinomenine 45 ~ 95mg/kg of monkey also have the sedation shown.Low dose of (5-10mg/kg) can extend the incubation period of the defensive conditionedreflex of mice and cat, trained reflex partial disappearance, and unconditioned reflex also has partial disappearance, and the process of excitation of prompting sinomenine to higher nervous activity has Inhibitory Effect.

1.3 other effect sinomenines have antitussive effect, and to mice (SO2 method) and cat (electricity irritation superior laryngeal nerve method), its antitussive is tired similar with codeine; To Cavia porcellus (SO2 method) then its only tire and codeine 1/4; Promethazine can strengthen its antitussive effect.When rats by intraperitoneal injection is heavy dose of, there is certain cooling effect.

Antiinflammatory action:

Sinomenine has the regressive effect shown to experimental arthritis, its mechanism may be affect hypophysis one adrenal system by hypothalamus, and has nothing to do with histamine release.Preventive effect is had to the initiative anaphylactic shock of Cavia porcellus.Sinomenine can reduce C-II induced arthritis in rats whole blood viscosity, and strengthens with dosage increasing action, but has no significant effect plasma viscosity, mainly because sinomenine improves erythrocyte deformability, reduces erythrocyte aggregation degree.

Immunosuppressive action:

Sinomenine is to body nonspecific immunity, and cellular immunization and humoral immunization all have inhibitory action, similar to cyclophosphamide effect.Sinomenine 25mg/kg, 50mg/kg, 100mg/kg lumbar injection or intramuscular injection obviously reduce the weight of mice charcoal Cl and spleen and thymus, and show the decline suppressing the phagocytic function of Turnover of Mouse Peritoneal Macrophages and cause cGMP/cAMP ratio in blood plasma; Stronger inhibitory action is had to tumor concomitant immunity and graft versus host disease.

To effect that is myocardium and heart rate:

Test the isolated guinea pig atrium that affects of myocardial contraction and heart rate, sinomenine can reduce the contractility of cardiac muscle, suppresses the self-disciplining that adrenal gland's rope brings out; Time more than 2.7 μm of ol/L concentration, suppress Guinea-pig Papillary Muscles contractility in concentration dependent.The negative chronotropic action of sinomenine is all observed in overall and isolated experiment, and can the positive chronotropic action of antagonism isoproterenol.Sinomenine can make isoproterenol, histamine amount effect curve is non-parallel moves to right, and reduces, in the anti-effect of noncompetitive Fructus Citri tangerinae, all have obvious antagonism to the positive resistant frequency caused by calcium chloride and positive inotropic with maximum reaction.Think that the negative inotropic action of sinomenine and negative chronotropic action are not by blocking beta receptor and H2 receptor thus, but block caused by slow Ca2+ influx.

Suppress the effect of fast sodium influx:

Affecting sinomenine and can reduce Guinea pig atrium irritability, extension function refractory stage cardiac electrophysiology, reduce the action potential maximum climbing speed of O phase and action potential amplitude, therefore sinomenine has inhibitory action to fast sodium influx.When heavy dose, the prolongation of effective refractory period exceedes the prolongation of action potential duration, APD.Activate with the slow channel of 25mmolK (+) Tyrode liquid depolarization cardiac muscle, now sinomenine 82 μm of ol reduce O phase rising maximum rate and action potential amplitude, have frequency dependence effect, point out it to have inhibitory action to slow inward calcium current; Have non-selective inhibitory action to Mg (2+)/Ca (2+) mixed potential that Mg (2+) causes, these results show that sinomenine has directly blocked calcium channel.Sinomenine can shorten the effect of heart muscle action potential to anti-acetylcholine, this effect is relevant with inward rectifying current with slow K (+) outward current of suppression.As can be seen here, sinomenine without selectively acting on ion transport, all may have inhibitory action to the transport process of Na (+), K (+), Ca (2+).

Antiarrhythmic effect:

Sinomenine 10-40mg/kg intravenous injection all has antagonism to a certain degree to several dissimilar arrhythmia that aconitine, Ouabain, calcium chloride, chloroform-epinephrine etc. bring out, 30-50mg/kg intravenous injection can be shortened Picrotoxin and bring out the rabbit arrhythmia persistent period, has obvious antagonism to the rat ischemia arrhythmia of following coronary artery occlusion.Sinomenine can play antiarrhythmic effect by the transhipment of suppression ions across membranes and suppression maincenter.

Resist myocardial ischemia, protect reperfusion injury and protect:

Sinomenine 50mg/kg lumbar injection, can reduce raising of Rat Ecg S-T section that pituitrin causes and T ripple, but not affect heart rate.The incidence rate that Reperfu-sion rhythm of the heart husband is normal can be reduced during sinomenine 27 μm of ol/L; When 270 μm of ol/L, filling property room can be suppressed completely to quiver generation again, to filling property damage again, there is protective effect.

Hypotensive effect:

Sinomenium acutum total alkali is to anesthesia or not anesthetized animal (dog, cat, rabbit, rat), and intravenous injection or gastric infusion all have the acute antihypertensive effect of affirmative, but continuous several times administration then produces tachyphylaxis.Anesthetized dog, after intravenous injection sinomenine 0.5-2.0mg/kg, occurs that cardiac output, heart rate, systolic pressure, diastolic pressure, left systolic period pressure, the maximum rate of change of left ventricular pressure, cardiac index and Peripheral resistance show immediately and reduces.Caused by the Peripheral resistance reduction of sinomenine hypotensive effect system, myocardial contraction reduction, cardiac output reduce.

Block nerves joint and Phrenic nerve diaphragm effect:

Sinomenine has concentration dependent inhibitory action to neuroganglion action potential, and its ID50 is 1.2mmol/L, has no significant effect, show that its site of action is at neuroganglion to the excitement of preganglionic fibre and conduction.The transmission of sinomenine energy reversibility blocking nerves muscle, in concentration dependent inhibitory action, the irritability of nerve trunk and conductivity are had no significant effect, neostigmine can not antagonism sinomenine to the retardation of Phrenic nerve diaphragm, and having booster action, prompting sinomenine has some action character of depolarizing muscular relaxant.

Impact on gastrointestinal activity:

Sinomenine to dog, monkey is oral often slight gastrointestinal untoward reaction.Have inhibitory action in vitro rabbit intestinal and Cavia porcellus intestinal, and can resist pilocarpine, histamine, acetylcholine and barium chloride cause spasm effect.But to dog in place and rabbit intestinal, intravenous injection sinomenine all causes the temporary transient excitement of small intestinal; Injection sinomenine can increase gastric secretion and acidity thereof.To gastrointestinal excitation, be caused by histamine release.

The effect of release histamine:

To dog intravenous injection sinomenine, in blood plasma, histamine content rises, blood pressure drops, and portal vein pressure rises, and promote that lymph generates, typical triple response can appear in subcutaneous injection, and can be antihistaminic and suppressed.Effect isolated alkaloid from Caulis Sinomenii of 12. pairs of receptors, Preliminary screening confirms that it all has the effect comparatively shown to benzodiazepine receptors, dopamine receptor, enkephalin receptor, α-adrenoceptor, angiotensin-ii-receptor.Inject low dose of sinomenine hydrochloride or Maxamine every day, can suppress rat granulation tissue and adjuvant-induced arthritis, this inhibitory action is mediated by H2 receptor and T cell respectively.

Saponaria officinalis:

The function of there is Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the symptom such as the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration are not well, sore swollen toxin, breast swell and pain.

Pharmacology: containing plant sapogenin glycoside, can stimulate gastric mucosa, cause mild nausea, thus increases bronchial secretion reflectingly and has phlegm-dispelling functions.Extract is oral to Canis familiaris L., and can promote that trachea is secreted, action intensity is: senea > Radix Platycodonis > Radix Polygalae, as by phenol red excretion rule being: senea > Radix Polygalae > Radix Platycodonis.But the oral Radix Polygalae decoct of anesthetized dog 1 g/kg, can not increase the secretion of tracheal mucus, may be in caused by narcotism because of animal.

Herba Senecionis Scandentis:

Antibacterial action

50% decoct, stronger antibacterial action is had to will Hayes dysentery bar mattress and staphylococcus aureus, valid density is respectively 1:1024 and 1:512, to bacillus such as typhoid fever, paratyphoid fever, paratyphoid fever, dysentery (Fu Shi, Boydii, Song Nei Shi), large intestine, distortion, cured sample anthraxs, and sarcina all has inhibitory action (in vitro doubling dilution).Oral absorption good (rat), the urine of discharge also has certain antibacterial action.

Anti-spirillum effect

50% decoct, in vitro to the leptospiral suppression of icterohemorrhagic form very strong (plastic plate method, test tube method); Various extract has In Vitro Anti spirillum effect in various degree, wherein better with ether extracting solution effect; The blood adopted after Cavia porcellus gavage, the urine got under rabbit or after intravenous injection, still has certain effect; Carry out experimental treatment to Cavia porcellus or cricetulus auratus, Herba Senecionis Scandentis ether extract unsatisfactory curative effect, only Herba Senecionis Scandentis mixture (separately containing Radix Bupleuri, close Citrus chachiensis Hort. grass, Pericarpium Granati) has certain protection to Cavia porcellus.

Other effects

Decoct is in test tube, and the trichomonas vaginitis of 1:40 concentration to people has inhibitory action.Produce the isolated alkaloid in each position of Herba Senecionis Scandentis or effective ingredient from Europe, have paralysis effect to nervus motorius, the sub-official of isolated guinea pig is shunk, and there is digitaloid cardiotonic.Propose sarracine (Sarracine) from congener Seneciosarrace-nius, to maincenter first excited rear suppression, can reduce blood pressure, have obvious spasmolysis to rat intestinal tube.Someone once suspected that sarracine Alkaloid had carcinogenesis, and through rat, mouse experiment, thinking can have obvious degeneration, gangrenosum acne, inflammatory to become at liver, but is not carcinogen.Congener Seneciohualtata has decreased heart rate through the preserved material (not containing alkaloid, and having reducing sugar, phenol, amine etc.) of ion exchange resin treatment again, extends Q-R gap, reduces blood pressure, reduce the effects such as breathing rate.The Herba Senecionis Scandentis that other various places, the world (Europe, South America, non-, Australia) are not of the same race, can be poisoning after the domestic animal such as people and Niu food, especially can cause liver cirrhosis.In Senecio, contained Pynolizidine Alkaloid has antitumor action, this and cause between hepatotoxicity and have certain relation.

Clinical practice

1. treat various diseases associated with inflammation and generally use decocting extractum sheet (every sheet weighs 0.35 gram) clinically, every 2 owe 3, and take 4 day, children's is cut down according to the circumstance.By the observation of 1338 examples, 29 kinds of various diseases associated with inflammation, cured person 830 example (62%), 334 examples that take a turn for the better (25%), invalid 174 examples (13%).Wherein comparatively outstanding to the curative effect of upper respiratory tract infection, acute tonsillitis, lobar pneumonia, acute bacillary dysentery, acute enteritis, acute appendicitis and erysipelas etc.To take in process the only individuals patients phenomenon such as have nauseating, loss of appetite and times of defecation to increase.In addition, once found 1 routine allergic drug eruption, through with after Claritin, namely took a turn for the better.

2. treat various ophthalmology illness and apply 50% Herba Senecionis Scandentis collyrium, within every 2 ~ 4 hours, drip 1 time, treat acute, subacute conjunctivitis 200 example, chronic conjunctivitis 150 example, trachoma acute stage 60, is routine, and trachoma chronic phase (cicatrix) 40 is routine, swimming pool conjunctivitis 20 example, superficial punctate keratitis 30 example, dendritic keratitis 60 example, corneal ulcer 40 example, amount to 600 examples, control rear effective person 378 example (63%), responder 215 example (36.8%), total effective rate is 98.8%, nonresponder 7 example (1.2%).

Another Herba Hieracii Umbellati (Herba Senecionis Scandentis) collyrium controls acute conjunctivitis 32 example, all cures.Once be the case of staphylococcus aureus by wherein conjunctival sac cultivation of cervical secretions, compared with chloromycetin eyedrops treatment group (18 example), both results antibacterial culturing the moon turn and clinical cure average time all very close.

In addition, once used 200% QIANLIGUANG ZHUSHEYE ear acupoint injection for curing central retina choroiditis 62 example, through 1 ~ 2 course for the treatment of, basic healing 28 examples (vision restoration is to more than 1.O), effective 7 examples, effective 21 examples (vision is slightly promoted), invalid 4 examples, worsen 2 examples

Therapeutic Method: be divided into by the ear acupoint the 2 groups: 1st group to be kidney, opticoel, the 2nd group is liver, order cave.Inject 1 every day, two groups of acupuncture point rotations injections 10 days are a course for the treatment of, row second course for the treatment of again every 2 ~ 3 days.Liver, kidney two acupuncture point can each notes 0.1 milliliter (cuticle mound); Eye, order two acupuncture point can respectively inject 0.4 milliliter.With Herba Senecionis Scandentis treatment primary disease without contraindication and side effect, course of disease person's cure rate within January is higher.

3. treat trichomonal vaginitis after vagina normal developing, dip in 100% Herba Senecionis Scandentis solution with the Cotton Gossypii gauze plug of band wire tail and put into intravaginal, after 24 hours, taken out voluntarily by patient.The many persons of infusorian first can dip in medicine with cotton swab or cotton balls and smear and wash vaginal wall, then put gauze plug.The next day 1 time, be for 5 times a course for the treatment of, menstrual phase suspend treatment.After 120 routine patient treatments, transference cure, leucorrhea reduces or disappears, and after 1 week, check leucorrhea microscopy negative patient 99 example, is classified as recovery from illness, accounts for 82.5%; Symptom alleviates, and leucorrhea reduces, and check infusorian number minimizing person 16 example, is classified as progress, accounts for 12.5%; Treat 5 times, transference cure, leucorrhea reduces, but leucorrhea microscopy positive 6 is routine, accounts for 5%.

4. treat leptospirosis and once applied sick 7 examples of the medium-sized and light-duty Leptospira grippotyphosa of Herba Senecionis Scandentis mixture treatment, all cure.

Flush Artemisia:

The ethanol of herb or the extract of acetone have the effect of anti-trichophyton (external).

Hair Radix Bupleuri:

Antibacterial spasmolytic is induced sweat.

Herba Lobeliae Chinensis:

Mouse mainline preserved material median lethal dose(LD 50) is 6.10 ± 0.26g/kg, and full Herba Lobeliae Chinensis element is 18.7 ± 2.0mg/kg, and amounting to crude drug is 9.35 ± 1.Og/kg.Rat preserved material gavage median lethal dose(LD 50) is 75.1 ± 13.1g/kg, lumbar injection 0.1-1.Og/kg, every day 1 time, and continuous 3 months, the inspection of body weight, Urine sediments analyzer and urine protein was all without exception; Medication group excrement is rarer, indicates certain catharsis effect, and pathological section inspection part medication Ren Mus is dirty has slight cloudy swelling not find significant organic pathological changes outward.

The LD50 of Herba Lobeliae Chinensis decoct mice iv is 6.10 ± 0.26g(crude drug)/kg.There is respiratory stimulant, the phenomenons such as manic uneasiness before dead, then twitch, generally dead in 5 minutes.The LD50 of Herba Lobeliae Chinensis preserved material rat ig is 95.1 ± 13.1g(crude drug)/kg.Rat ip every day preserved material 0.1,0.3 and 1.0g(crude drug)/kg, continuous 3 minutes, the discovery all without exception of body weight, Urine sediments analyzer and urine protein examination.

Pathologic finding, except partial rat kidney has slight cloudy swelling, has no remarkable organic change.

Rhizoma Paridis:

(1) antibacterial action

Rhizoma Paridis water logging agent and decoct all have inhibitory action to Bacillus typhi, paratyphoid bacillus A, will he and shigella flexneri in vitro, and crude drug water logging agent is stronger than decoct antibacterial action.

(2) spermicide effect

The sperm of Rhizoma Paridis 70% ethanol extraction to rat, mice and people has spermicidal effect.Its extract exempts from vagina administration, has the suppression spermatiation of 60% during 100mg/.

(3) calm, analgesic activity

Alcohol extract, to mouse stomach, can reduce spontaneous activity in mice, has obvious sedation; Measure with electrostimulation and hot plate method, all have obvious analgesic activity.

(4) relieving asthma, antitussive action

Cavia porcellus oral Rhizoma Paridis decoct has obvious antiasthmatic effect (histamine spray method).Extract (totally five kinds) has obvious antiasthmatic effect when 1/2-1/5 median lethal dose(LD 50), and effect is similar to the aminophylline of 1/2 median lethal dose(LD 50).One of extract is Saponin, another three kinds of Liebermsnn reacting positives.Mouse gavaging decoct has obvious antitussive action (sulfur dioxide draws the method for coughing), but without phlegm-dispelling functions (phenol red method).

(5) Rhizoma Paridis (unreceipted kind) 100% preparation all has antibacterial action to the various pathogens such as Bacterium entericum and pyococcus in vitro, fails to prove that it has bacteriostasis with decoct.Alcohol extract 7.8 mg/ml kills leptospira effect in vitro, with concentration water decoction then without this effect.Containing getting matter in Rhizoma Paridis, its antivirus action has important relationship with it.

(6) toxicity, mouse gavaging decoct 30-60g/kg, has no dead in 3 days.Mice gavages 0.4g every day, every day 3 times, for three days on end; Or intravenous injection 0.2%0.4ml/ only, all without dead.Therefore toxicity is very low.

(7) there is stronger bacteriostasis to Asia influenza A virus, all have bacteriostasis to dysentery bacterium, Salmonella paratyphi, Salmonella, paracolon, bacillus pyocyaneus, staphylococcus aureus, Hemolytic streptococcus, meningococcus etc.

(8) decoct has antagonism for " aseptic inflammation " caused by dextran.

(9) give rat gavage, obviously can lower the content of Vitamin C in adult rat adrenal tissue element, promote adrenal function, but little on young Mus thymic weight impact.

(10) there is direct contraction containing Saponin in vitro rabbit ear vascular smooth muscle.

(11) its decoct and the Ileum From A White of Saponin to Cavia porcellus all have excitation; The two all has haemolysis.

(12) have antitumor action, its methanolic extract has Developing restraint effect to the strain of Hela tumor in testing in vitro; Total saponins obviously can suppress the growth of white mice h22 oncocyte.

(13) Rhizoma Paridis decoct all has bacteriostasis in various degree to staphylococcus aureus, Hemolytic streptococcus, meningococcus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli and bacillus pyocyaneus.

Caulis et Folium Pothi Repentis: pharmacology: heart tonifying spasmolytic.

Galla Chinensis bark:

1. astriction:

Containing tannic acid, have the effect of precipitating proteins, after skin ulcer face, mucosa are in contact with it, namely tissue protein is solidified, and forms layer protecting film, plays astriction, simultaneously thin vessels also oppressed contraction, blood clotting and in anastalsis.The protein of glandular cell is solidified and causes secretion to suppress, make mucosa dry, the precipitation of teleneuron protein, can in tannic acid contained in faint local anesthesia phenomenon, Galla Chinensis on normal intestinal motility without very affecting, but alleviate enteritis due to its astriction, therefore can diarrhoea be prevented.

2. antibacterial action:

In vitro tests shows: Galla Chinensis decoct all has significantly antibacterial and bactericidal action to staphylococcus aureus, beta hemolytic streptococcus, streptococcus pneumoniae, bacillus pyocyaneus, dysentery bacterium, anthrax bacillus, diphtheria corynebacterium, escherichia coli, Typhoid and paratyphoid bacillus etc.Galla Chinensis liquid after proposing its tannic acid with ether still has bacteriostasis.But the decoct in Galla Chinensis heart portion is without antibacterial action.

Seven leaf Folium Viticis Negundos:

1. antiinflammatory action Folium Viticis Negundo is to the formaldehyde foot swelling of adrenalectomy male rat, has antiinflammatory action.The suppression ratio that Folium Viticis Negundo extract 500 μ g/ml is 105%, 4 μ g/ml to the suppression ratio that the rat macrophage histamine release suppression ratio that 48/80 causes is 112%, 110 μ g/ml is 54%.

2. anti-genotoxicity effect Folium Viticis Negundo extract department of pediatrics syrup and tablet, there is no genotoxicity effect, but the genotoxicity of dimethylnitrosamine (dimethylnitrosamiue), methylmethane sulphur salt (methylmethanesulfonate) and tetracycline (tetracyclin) can be suppressed, show as the generation reducing the micronucleus Polychromatic erythrocytes that these three kinds of toxin bring out.

Model case

Case 1

Shao so-and-so, female, 6 years old, to be bitten right dorsal portion by poisonous snake Trimeresurus mucrosquamatus (Cantor). on the road left school on June 23rd, 1994, because this patient lives in remote mountain areas, have inconvenient traffic, through locality, doctor among the people is invalid with Chinese herbal treatment seven days, transfer here to go to a doctor, see its right lower extremity and the following edema of umbilicus, expression is painful, wound and toes fester, pus and blood water overflows more than, stink is unpleasant, through with normal saline by wound and rotten position cleaning and sterilizing, see that its toe major part is downright bad, then necroses is removed, wrap antiseptic gauze, then with antidote for snake bites external application affected part of the present invention, reserve wound, wrapping is fixing, within three days, change a medicine, through the treatment of two weeks, although lose four foot toes, but still obtain recovery from illness, cause this routine patient's mild disability, mainly after wound, treatment is lack of standardization, fail to clean a wound in time, adopt an effective measure, cause the increase of successive treatment difficulty.

Case 2

Feng so-and-so, man, 86 years old, when going to toilet in 2007 on JIUYUE 13, evening 11 time, below whole right thigh all edema are caused by poisonous snake Trimeresurus mucrosquamatus (Cantor). right instep of biting in the thick grass of side, lavatory, swell and ache, wound bleeding is more than, around purple, partial skin is got blister, large as goose egg, because this patient age is comparatively large, the corresponding increase for the treatment of difficulty.Measuring blood pressure 60/90mmhg, heart rate 140bpm, with normal saline by cleaning wound, the venom in wound purple place's congestion and blister is released with acupuncture needle, antidote for snake bites 60g of the present invention for oral administration, external 200g antidote for snake bites powder furnishing pasty state, external application is swelling skin place below wound and whole shank, enjoins patient to be sprinkled upon on antidote for snake bites through conventional cold water, keeps antidote for snake bites humidity, heighten the effect of a treatment, after one day, pain symptom is eased, and changes dressings once after three days, sees that symptom greatly takes a turn for the better, wound healing after one week, swelling is eliminated and fully recovers.

Case 3

Lee so-and-so, female, 49 years old, dining room is gone to go to work morning 4 on March 28th, 2015, on water vat limit, dining room by poisonous snake Trimeresurus mucrosquamatus (Cantor). bite the right hand back of the body, feel hurt like hell immediately, there is nausea and vomiting in secondary, palpitation and short breath, incessant sweating due to debility, she is sent to local commune hospital and goes to a doctor by its household and colleague, because this hospital cannot cure without antidote for snake bites, in the morning eight time, transfer here seek medical advice, see its back of the hand swelling, wound bleeding is more than, atropurpureus around, patient's pale complexion, moan ceaselessly, absentminded, thirsty, wound refuses pressure, through cleaning a wound with normal saline, with homemade antidote for snake bites water sterilization, extrude wound gently, wound circumference congestion is allowed to overflow, reduce Serpentis poison in body, wound is covered with medical cotton, then the affected part in swelling is applied with antidote for snake bites of the present invention, with binder, medicated bag is tied again, within three days, change once, antidote for snake bites 60g of the present invention is taken orally by warm water, continuous use 12 days, every day three times, obtain recovery from illness.

The above embodiment only have expressed the detailed description of the invention of the application, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the application's protection domain.It should be pointed out that for the person of ordinary skill of the art, under the prerequisite not departing from technical scheme design, can also make some distortion and improvement, these all belong to the protection domain of the application.

Claims (3)

1. treat a Chinese medicine composition for venom, it is characterized in that, be made up of the raw material of following weight portion:

Tian Bianju 7-9 part, Radix Angelicae Dahuricae 10-14 part, Herba Asari insignis 5-7 part, Herba Ophioglossi 9-13 part, August white 4-6 part, Saponaria officinalis 4-6 part, Herba Senecionis Scandentis 9-11 part, flush Artemisia 7-9 part, hair Radix Bupleuri 5-7 part, Herba Lobeliae Chinensis 7-9 part, Rhizoma Paridis 4-6 part, Caulis et Folium Pothi Repentis 4-6 part, Galla Chinensis bark 4-6 part, seven leaf Folium Viticis Negundo 5-7 parts.

2. a kind of Chinese medicine composition for the treatment of venom according to claim 1, is characterized in that, be made up of the raw material of following weight portion:

Tian Bianju 8 parts, the Radix Angelicae Dahuricae 12 parts, Herba Asari insignis 6 parts, Herba Ophioglossi 11 parts, white 5 parts of August, Saponaria officinalis 5 parts, Herba Senecionis Scandentis 10 parts, flush Artemisia 8 parts, hair Radix Bupleuri 6 parts, Herba Lobeliae Chinensis 8 parts, Rhizoma Paridis 5 parts, Caulis et Folium Pothi Repentis 5 parts, 5 parts, Galla Chinensis bark, seven leaf Folium Viticis Negundos 6 parts.

3. a kind of application of Chinese medicine composition on treatment venom for the treatment of venom according to claim 1 and 2.