CN103705751A - Traditional Chinese medicine composition for treating rheumatic lumbago and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating rheumatic lumbago and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw medicines: cassia twig, Philippine paphiopedilum, notopterygium root, pubescent angelica root, angelica root, jasminum lanceolarium, capreolus velvet, furcate screwpine root, pawpaw, silkworm excrement, loose knot, sinomenium acutum, sweetgum resin, red sage root, vitex stem, crossostephium chinense, beautiful sweetgum fruit, achyranthes bidentata, suberect spatholobus stem and pangolin. The traditional Chinese medicine composition disclosed by the invention has the main efficacies of dispelling cold, removing dampness, and warming and activating meridian; when being used for treating the rheumatic lumbago, the composition has the advantages of best curative effect, capability of directing at lesions, short treatment course, easiness in medicine preparation, little toxic or side effect, convenience in administration, difficulty in relapse after cure and low cost.

Description

Be used for the treatment of Chinese medicine composition of lumbago due to pathogenic wind-dampness and preparation method thereof

 

Technical field

The present invention relates to be used for the treatment of the medicine of lumbago due to pathogenic wind-dampness, particularly a kind of Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness and preparation method thereof.

 

Background technology

Lumbago due to pathogenic wind-dampness is due to waist, to suffer the invasion and attack of wind-cold damp pathogen, causes the resistance of blood vessels numbness, moves not smooth, thereby causes the clinical symptoms such as waist swelling and pain, apathy.Modern medicine is thought the generation of primary disease, with tired, catch cold with moist relevant, as occupied for a long time wetland, tired backlash wind in spite of the rain, is changed wet clothing not in time, summer and autumn cover of sleeping not have a cold etc.In the course of time, can make the tissue degeneratiaon that gets involved, the chronic back pain that causes touching difficulty to heal.Lumbago due to pathogenic wind-dampness is apt to occur in muscle, muscle arteries and veins, ligament, fat and subcutaneous tissue.The topmost symptom of lumbago due to pathogenic wind-dampness is lumbago, and waist is sent out heavy, and as there being weight tenesmus, tired rear or overcast and rainy increasing the weight of, takes a turn for the better when fine day or warmer climate; Waist bend forward and backward active receiving restriction, for a long time sitting; Fatiguability is weak, and whole body is listless and aching heavy, and affected part is afraid of cold.

Motherland's medical science thinks, pain refers to waist being invaded by exogenous pathogen, or because of impairment caused by overstrain, or by suffering from a deficiency of the kidney, causes that QI-blood circulation lacks of proper care, spasm of collateral, and the class disease that waist one or both sides pain is cardinal symptom of take due to supporting is lost at waist mansion.Lumbago all can occur throughout the year, and its sickness rate is higher, has report to think that 80% of world population suffered from lumbago and backache abroad.Lumbago one disease, ancient literature early has discussion, and < < Plain Questions arteries and veins wants precise and tiny opinion > > to point out: " waist person, house of kidney, incapable of turning round, kidney is by exhausted." feature of lumbago due to renal deficiency has been described.< < Plain Questions thorn lumbago > > thinks that lumbago mainly belongs to the disease of sufficient the six channels, and feature and the corresponding acupuncture and moxibustion therapy of lumbago occur while having set forth respectively sufficient three sun, foot three the moon and eight extra-channel meridians pathological changes.Through > >, at other chapters, has also narrated respectively character, position and the scope of lumbago in < <, and propose the cause of disease take empty, tremble with fear, wet as main.< < Medical Treasures of the Golden Chamber > > has started lumbago to carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, wound is shenqi pill, Rhizoma Zingiberis Siberian cocklebur art soup treatment for lumbago due to cold-damp for lumbago due to renal deficiency, and two sides are always by being paid attention to later age.The < < of Sui General Treatise on the Cause and Symptoms of Diseases > >, in etiology, has enriched the causes of disease such as " waist is hindered by pendant Sui ", " straining in kidney ", is divided into sudden onset of lumbago and chronic lumbago in classification.The < < of Tang Qianjin Yao Fang > > < < medical secrets of official > > has increased the contents such as massage, a surname's guide therapeutic and nursing.Gold dollar period, more abundant to the understanding of lumbago, as < < danxi's experiential therapy lumbago > > points out that lumbago diseases is because having " damp and hot, suffer from a deficiency of the kidney, blood stasis, frustrate sudden strain of a muscle, accumulation of phlegm ", and emphasize the important function of suffering from a deficiency of the kidney.The Qing Dynasty, controls the understanding of rule existed system and abundant clinical experience to lumbago etiology and pathogenesis and card.The loose rock collection of < < seven lumbago > > points out: " so pain have deficiency and excess minute, so-called empty person, be the spiritual asthenia of qi and blood of two kidneys also, all speech deficiency syndrome, all two kidneys are from sick ear.So-called real person, non-kidney man, from real, is among two waist meridians blood vessels, the institute wet for wind and cold invades, and dodge the institute that Na frustrates gas and hinder, among waist internal cavity, for damp-phlegm blood stasis stagnates obstructed, be bitterly, when demonstrate,proving according to arteries and veins, distinguish and know and divide and rule it." to lumbago commonly encountered diseases because of and typing done summary.< < Zhengzi Huibu lumbago > > points out: " only the kidney invigorating is for first; then with the finding person of heresy to treat; mark symptomatic treatment in acute condition; this urgency is effected a permanent cure; just pain should be dredged evil stagnant; manage channel tunnel, bitterly should mend true strength for a long time, gas nourishes blood." thisly distinguish specimen Therapeutic Principle in the order of urgency, to highly significant clinical.

Etiology and pathogenesis: 1, exopathogen invasion and attack are how moist by place, residence, or work exposure to wind when sweating, clothing is wrapped up in cold wet, or catch a cold in spite of the rain, or the season of long summer, work and steam part in damp and hot friendship, the evil poison of the six climate exopathogens such as cold-damp, damp and hot, summer-heat is taken advantage of the void of work, invasion and attack waist mansion, causes waist passages through which vital energy circulates to be obstructed, and lumbago does not freely occur QI and blood.If cold-evil is disease, cold impairment of YANG, main spasm, waist mansion yang-energy is both empty, therefore channels is stopped up again, holds back the raw lumbago of contracture.If damp is disease, moist heavy, viscous, under become, block up mechanism of qi, can make waist mansion through the stagnation of QI and not all right, the blood network stasis of blood and not smooth, so that muscle spasm of muscles and vessels and send out lumbago.Experience damp and hot heresy, thermal burn is cloudy, and wet impairment of YANG, and damp and hot viscous, stop up and hold back passages through which vital energy circulates, strongly fragrant and the not all right and lumbago of QI and blood.2, qi depression to blood stasis waist continues firmly, and too, or long-term position is not just in work, or waist undue force, gets rid of gas sprain and contusion, tumbling down wound, and strain waist mansion muscle arteries and veins QI and blood, or prolonged illness people network, QI-blood circulation is not smooth, all can make waist obstruction of QI, blood network stasis blocking and raw lumbago.3, the empty natural endowment of deficiency of the kidney body is not enough, and too, or weakness due to chronic disease, or worn with age, or chamber do not save, so that deficiency of the kidney, be difficult to moisten and support waist Fu Jinmai and lumbago occurs in fatigue in addition.It is the important pathogenesis of lumbago that ancient Chinese medicine doctor is all paid attention to deficiency of the kidney body void.As < < Ling Shu Miraculous Pivot or Divine Axis five infirmity body fluid, other > > says: " void, therefore lumbago, backache and aching legs." < < Jing Yue's complete work lumbago > > also thinks: " deficiency syndrome ten of lumbago occupy eight or nine." waist is house of kidney, is the territory that the vital essence of kidney is irrigate.Exterior and interior relation between kidney and bladder, meridian of Foot-TAI YANG is crossed it.In addition, appoint, superintend and direct, rush, be with all arteries and veins, also cloth therebetween, therefore internal injury outer not suffering from a deficiency of the kidney.And the damp and hot all heresies of affection of exogenous wind-cold, with damp pathogen being sticky and stagnant in nature, wet flowing down, the easiest numbness waist, so diseases caused by exogenous pathogenic factor always be unable to do without damp for suffering from.Inside and outside two because of, influence each other, as < < miscellaneous diseases source and course rhinoceros candle lumbago diseases source and course > > points out: " lumbago, the empty and evil objective disease of vital essence is also.Suffer from a deficiency of the kidney it also, the damp and hot phlegm retention of wind and cold, it marks qi depression to blood stasis sprain and contusion also, or from mark, or from this, your nothing is lost it should." illustrating that suffering from a deficiency of the kidney is morbidity key point, the numbness resistance that wind and cold is damp and hot is not all right, and Chang Yin suffers from a deficiency of the kidney and visitor, though otherwise sense exopathogen, the also unlikely lumbago that occurs.As for labour, sprain, relevant with blood stasis, also not rare clinically.

In Chinese medicine, a lumbago minute deficiency and excess opinion is controlled, and empty person be take Bu Shen Zhuang waist as main, the double QI and blood of taking good care of; Reality person is eliminating evil active for wanting, for the cause of disease, execute with blood circulation promoting and blood stasis dispelling, dispelling cold and removing dampness, rushes down clearly the methods such as damp and hot.The deficiency and excess folder person that holds concurrently, knows the secondary from the primary, giving consideration to both the incidental and fundamental treatment.Lumbago due to cold-damp symptom: waist cold type of pain is weighing, changes one's position unfavorable, increase the weight of gradually, whenever overcast and rainy or waist sense cold after aggravation, sore spot happiness temperature, obtains and hotly subtracts, tongue is white greasy and moisten deep and tense pulse or late heavy.Method for the treatment of: dispelling cold and removing dampness, promoting the flow of QI in the collateral by warming the meridian.Side's medicine: eliminating dampness by diuresis soup; Lumbago due to damp-heat symptom: waist hip tearing pain, hold up contracture, sore spot is with hotness, and often after summer or waist heat, pain is acute, meets cold type of pain alkali, feeling thirst but no desire to drink, urine yellow skin is red, or afternoon fever of the body, slightly sweating, red tongue with yellowish and greasy fur, soft and rapid pulse or stringy and rapid pulse.Method for the treatment of: clearing away heat-damp and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral.

At present, the medicine of modern medicine treatment rheumatism can be divided into following a few class:

1, nonsteroidal anti-inflammatory agent (NSAIDs): the effect of this type of medicine, be mainly antipyretic, antiinflammatory and analgesia, and reach reduce inflammation reaction and object.Be that aspirin (aspirin) is so far still for treating the active drug of acute rheumatic fever and rheumatic arthritis the earliest.Produced afterwards various Salicylates, conventional have ibuprofen, a diclofenac, indomethacin, piroxicam, naproxen etc., but the pharmacokinetics of various medicines and untoward reaction are different, mainly to gastrointestinal, kidney, liver and blood system, must note dosage during use, usage, side effect etc.

2, adrenocortical hormone: because it not effects a radical cure medicine, long-term a large amount of uses can be brought out infection, osteoporosis, femur head necrosis, diabetes, peptic ulcer, hypertension, psychological problem etc.; And easy generation state of an illness rebound phenomenon as too fast in drug withdrawal, therefore should note according to disease kind and the state of an illness, regulates the kind and the dosage that use medicine.Except patient with severe symptoms, in principle with low dose, be advisable the short course for the treatment of.

3. the antirheumatic (DMARDs) that improves the state of an illness is called again slow effect antirheumatic.This type of medicine comprises that numerous species structure is different, acts on different medicine.Their general character is that onset is slow, has certain cumulative action, therefore after drug withdrawal, effect disappears also slower, still can maintain a period of time.The toxic action that the internal organs that various medicines are wanted body weight for humans above (liver, kidney, bladder, lung, gastrointestinal, gonad) and tissue (bone marrow) are had nothing in common with each other.

 

Summary of the invention

Technical problem to be solved by this invention is, a kind of Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness and preparation method thereof is provided, Chinese medicine composition of the present invention has the effect of dispelling cold and removing dampness, promoting the flow of QI in the collateral by warming the meridian pain relieving, cure mainly lumbago due to pathogenic wind-dampness curative effect best, the focus of going directly, has the course for the treatment of shorter, medicament is easy to manufacture, toxic and side effects is little, and convenient drug administration is difficult for recurrence and advantage with low cost more afterwards.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Radix seu Caulis Jasmini lanceolarii, Capreolus Capreolus (Linnaeus)., Radix Pandani Furcati, Fructus Chaenomelis, Bombyx mori L., Lignum Pini Nodi, Caulis Sinomenii, Resina Liquidambaris, Radix Salviae Miltiorrhizae, Caulis Viticis Cannabifoliae, Chinese mugwort, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Caulis Spatholobi and Squama Manis in thousand.

Described Chinese medicine composition is comprised of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 10-30 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 15-25 weight portion, Rhizoma Et Radix Notopterygii 16-31 weight portion, Radix Angelicae Pubescentis 16-31 weight portion, Radix Angelicae Dahuricae 11-21 weight portion, Radix seu Caulis Jasmini lanceolarii 16-25 weight portion, Capreolus Capreolus (Linnaeus). 16-25 weight portion, Radix Pandani Furcati 16-30 weight portion, Fructus Chaenomelis 16-30 weight portion, Bombyx mori L. 12-25 weight portion, Lignum Pini Nodi 14-25 weight portion, Caulis Sinomenii 16-24 weight portion, Resina Liquidambaris 16-31 weight portion, Radix Salviae Miltiorrhizae 16-25 weight portion, Caulis Viticis Cannabifoliae 12-25 weight portion, Chinese mugwort 12-31 weight portion in thousand, Fructus Liquidambaris 12-20 weight portion, Radix Achyranthis Bidentatae 10-21 weight portion, Caulis Spatholobi 16-31 weight portion and Squama Manis 16-31 weight portion.

Described Chinese medicine composition is comprised of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 15-25 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 17-23 weight portion, Rhizoma Et Radix Notopterygii 18-27 weight portion, Radix Angelicae Pubescentis 18-26 weight portion, Radix Angelicae Dahuricae 13-18 weight portion, Radix seu Caulis Jasmini lanceolarii 18-22 weight portion, Capreolus Capreolus (Linnaeus). 19-21 weight portion, Radix Pandani Furcati 19-26 weight portion, Fructus Chaenomelis 19-26 weight portion, Bombyx mori L. 15-22 weight portion, Lignum Pini Nodi 18-22 weight portion, Caulis Sinomenii 19-23 weight portion, Resina Liquidambaris 19-27 weight portion, Radix Salviae Miltiorrhizae 19-23 weight portion, Caulis Viticis Cannabifoliae 15-22 weight portion, Chinese mugwort 18-26 weight portion in thousand, Fructus Liquidambaris 15-20 weight portion, Radix Achyranthis Bidentatae 15-21 weight portion, Caulis Spatholobi 23-31 weight portion and Squama Manis 20-27 weight portion.

Described Chinese medicine composition is comprised of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 21 weight portions, Paphiopedilum parishii(Rchb. F.) Pfitz 20 weight portions, Rhizoma Et Radix Notopterygii 22 weight portions, Radix Angelicae Pubescentis 23 weight portions, the Radix Angelicae Dahuricae 16 weight portions, Radix seu Caulis Jasmini lanceolarii 20 weight portions, Capreolus Capreolus (Linnaeus). 20 weight portions, Radix Pandani Furcati 23 weight portions, Fructus Chaenomelis 23 weight portions, Bombyx mori L. 17 weight portions, Lignum Pini Nodi 20 weight portions, Caulis Sinomenii 21 weight portions, Resina Liquidambaris 23 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Caulis Viticis Cannabifoliae 18 weight portions, Chinese mugwort 22 weight portions in thousand, Fructus Liquidambaris 17 weight portions, Radix Achyranthis Bidentatae 17 weight portions, Caulis Spatholobi 26 weight portions and Squama Manis 23 weight portions.

In order better to realize foregoing invention object, the invention provides a kind of preparation method that is used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness, it is characterized in that, the dosage form of described Chinese medicine composition is emplastrum, described preparation method comprises the following steps:

A, according to parts by weight, take all raw medicinal materials, put into ethanol heating and refluxing extraction 3 times, merge three extracting solution and obtain extracting solution one;

B, again by the medicinal residues of ethanol extraction in step a, add water heating and refluxing extraction 2 times, merge 2 extracting solution and obtain extracting solution two;

C, extracting solution one and extracting solution two merged, concentrated, obtain extractum, the concentrated modulation of heating.

In described step a, the raw medicinal material taking by weight adds in the ethanol that the determining alcohol of 5 times of raw medicinal material gross weights is 85%, heating and refluxing extraction 3 times, and each 2-5 hour, merges extracting solution standing, obtains extracting solution one.

In described step b, the medicinal residues that in step a, ethanol extraction is crossed are added to water heating and refluxing extraction 2 times, each 1-3 hour, merges extracting solution standing, obtains extracting solution two.

In described step c, extracting solution one and extracting solution two merged, in suction concentrating under reduced pressure tank, be decompressed to 0.03-0.09MPa, when being concentrated into temperature and being 60-90 ℃, relative density is 1.03, the extractum that temperature to 75 is ℃-92 ℃; Continue the concentrated emplastrum of modulating to obtain of heating.

In order better to realize foregoing invention object, the present invention provides again a kind of preparation method that is used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness, it is characterized in that, the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:

A, according to parts by weight, take Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis, add above-mentioned four kinds of water soaking 1-3 hour that raw medicinal material mixture 3-4 doubly measures, extract the volatile oil of 1-3 hour, collect volatile oil, medicinal liquid filters, and medicinal residues are standby;

B, by the medicinal residues in step a with remain other raw medicinal materials and mix, add in the ethanol that alcoholic degree is 75-80%, soak 1-2 hour, extract twice, each 2 hours, adding for the first time amount of alcohol was 4 times of mixture, adding for the second time amount of alcohol is 7 times of mixture, and merge extractive liquid, filters; Above two filtered solutions merge to filter, and when filtered solution is evaporated to relative density and is 88 ℃, 1.13-1.50 precipitate with ethanol, adjusts concentration of alcohol to 73-96%, get supernatant concentration to relative density 1.13-1.50 while being 88 ℃, obtain extractum;

C, get the extractum that step b obtains, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.

 

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: Chinese medicine composition of the present invention be take dispelling cold and removing dampness, promoting the flow of QI in the collateral by warming the meridian pain relieving as main, it is best that treatment lumbago due to pathogenic wind-dampness has curative effect, the through focus of energy, the course for the treatment of is shorter, medicament is easy to manufacture, toxic and side effects is little, and convenient drug administration is difficult for recurrence and advantage with low cost more afterwards.

 

The specific embodiment

Chinese medicine external therapy is one of the most frequently used clinically external treatment of Chinese medicine, the < < Handbook of Prescriptions for Emergencies > > of Jin Daige flood work, the < < Qianjin Yao Fang > > of the Tang Dynasty Sun Simiao, < < Qianjin Yi Fang > >, in the < < Compendium of Materia Medica > > of the < < medical secrets of official > > of Wang Taozhu and Ming Dynasty's Li Shizhen (1518-1593 A.D.), contained therapy has all related to Chinese medicine external therapy.Because meridians have interior genus internal organs, outer network podomere, link up the exterior and the interior, run through upper and lower effect, thus not only can treat local patholoic change, but also can reach by external application the object for the treatment of systemic disease.Medicine, by the stimulation to local acupuncture point, penetrates through skin, excites through feeling pulse gas, promotes internal organs QI-blood circulation, plays therapeutical effect; Skin is thinner, neural, blood vessel is abundanter, therefore have compared with absorbability by force and rapidly, there are good impression and conduction function, when the medicine with suitable treat in time, all local teleneuron be can stimulate, internal organs and tissue physiology's activity and pathological change improved, the immunity of enhancing body and resistance against diseases.Chinese medicine external has been avoided inconvenience and misery and lasting medicine oral and that injection brings, has avoided the first pass effect of liver and interference and the Degradation of gastrointestinal factor, reduces individual variation, rapid-action, strong drug action, and without wound, no pain, easy to use.

The traditional Chinese medical science thinks that a lumbago minute deficiency and excess opinion controls, and empty person be take Bu Shen Zhuang waist as main, the double QI and blood of taking good care of; Reality person is eliminating evil active for wanting, for the cause of disease, execute with blood circulation promoting and blood stasis dispelling, dispelling cold and removing dampness, rushes down clearly the methods such as damp and hot.The deficiency and excess folder person that holds concurrently, knows the secondary from the primary, giving consideration to both the incidental and fundamental treatment.It is primary treatment principle that dispelling cold and removing dampness, promoting the flow of QI in the collateral by warming the meridian pain relieving are take in the present invention, a kind of Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness is provided, has comprised Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Radix seu Caulis Jasmini lanceolarii, Capreolus Capreolus (Linnaeus)., Radix Pandani Furcati, Fructus Chaenomelis, Bombyx mori L., Lignum Pini Nodi, Caulis Sinomenii, Resina Liquidambaris, Radix Salviae Miltiorrhizae, Caulis Viticis Cannabifoliae, Chinese mugwort, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Caulis Spatholobi and Squama Manis in thousand.

Wherein, the pharmacological property of each raw medicinal material is as follows:

Ramulus Cinnamomi: pungent, sweet, warm in nature; Enter bladder, the heart, lung meridian.< < Amplification on Materia Medica addendum > >: " Zhong Jingzhi table Ramulus Cinnamomi, non-table has void to mend it with osmanthus; Defended ailment said due to cold or exposure, therefore sick spontaneous perspiration is sent out its heresy with Ramulus Cinnamomi, defended and show close antiperspirant from stopping, non-Ramulus Cinnamomi can be received antiperspirant and control it." < < Compendium of Materia Medica > >: " Herba Ephedrae is all over thorough fur, therefore specially in diaphoresis and cold-evil is loose, lung governing skin and hair, pungently walks lung also.Ramulus Cinnamomi reaches battalion thoroughly to be defended, thus can expelling pathogenic factors from muscles and ailment said due to cold or exposure is gone, spleen main management, lung master defend, and the sweet spleen of walking is pungently walked lung also." < < book on Chinese herbal medicine converges speech > >: " Ramulus Cinnamomi, dispersing wind and cold, by pathogenic factor in the exterior, send out antiperspirant evil, and cough-relieving is coughed, and removes the medicine of wind pain between podomere also.Though abnormal smells from the patient is not from hot, body belongs to branch, only can disperse between the fur flesh natural fibre line of meat parade arm knee joint podomere part." function diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea stomachache; Lump in the abdomen caking; The thoracic obstruction; Cardiopalmus; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention water-retention, edema, cardiopalmus, renal mass.

Paphiopedilum parishii(Rchb. F.) Pfitz: pungent; Bitter; Flat.Return: lung; Stomach; Kidney channel.Function cures mainly: relieving cough and asthma; Wind-expelling pain-stopping.Main pulmonary tuberculosis; Cough; Heavy breathing Zhong chuan; Rheumatic ostalgia; Gastroenteritis.

Rhizoma Et Radix Notopterygii: acrid in the mouth, hardship, warm in nature; Enter bladder, kidney channel.< < property of medicine opinion > >: " control harmful wind, aphonia in silence, the blood leprosy of itching, hands and feet caused by paralysis, the askew heresy of actinal surface, insensitive impediment all over more." < < product remittance essence is wanted > >: " main all joints being painful all over, flesh table eight winds coming from eight orientations harmful climatic factors, except new and old rheumatism, row's slough cellulitis skin ulcer." < < Thunder God is concocted property of medicine solution > >: " Rhizoma Et Radix Notopterygii gas belongs to clearly sun, and benefaction edema caused by disorder of QI relaxes and do not hold back, and rises and can sink, male and be apt to fall apart, and can deliver heresy, therefore the sun small intestinal of starting with.Foot sun bladder is with reason urticaria, though if its function is different from Radix Angelicae Pubescentis, reality is the exterior and the interior mutually." the loose exterior cold of function, wind-damp dispelling, sharp joint, pain relieving.Main affection of exogenous wind-cold, has a headache lossless, edema due to wind pathogen edema, sore swollen toxin.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.The cold expelling that induces sweat, expelling wind and dampness, pain relieving.Rhizoma Et Radix Notopterygii volatile oil has antiinflammatory and anti-allergic effects. and after gastric infusion, xylol dropsy of ear, carrageenin and dextran foot swelling have inhibitory action.

Radix Angelicae Pubescentis: expelling wind and dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache.Anemofrigid-damp arthralgia.The pungent loose hardship of these product is dry, and the fragrant temperature of gas is logical, and merit be apt to Eradicates rheumatism, and stopping numbness pain is dispelling the wind and dampness pathogens arthralgia pain principal agent, and no matter new of a specified duration the arthromyodynia due to all wind-cold damp pathogens is, all can apply; Because it is main, enter kidney channel, property is kind descending, especially with waist knee joint, the lower limb joints of foot pain subordinate cold-damp person of portion, is advisable.Control the anemofrigid-damp arthralgia of the damp that is affected by the cold, muscle, back, brothers' pain, normal and Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Radix Achyranthis Bidentatae are equal to use, as Radix Angelicae Pubescentis soup (< < young new book > > alive); If with compatibilities such as Herba Taxilli, the Cortex Eucommiae, Radix Ginsengs, can control arthromyodynia with the passing of time weakened body resistance, soreness of the waist and knees, joint joint stuffiness person, as Radix Angelicae Pubescentis et Herba Taxilli Decoction (< < prescriptions worth thousand gold > >).Wind and cold is held wet exterior syndrome under the arm.The pungent loose temperature of these product is logical bitter dry, can dispersing wind and cold wet and induce sweat, and controls the headache that affection of exogenous wind-cold holds under the arm due to wet nose heave, all over the body pain to the greatest extent.SHAO YIN headache.These product are apt to search volt wind into kidney channel.

The Radix Angelicae Dahuricae: acrid in the mouth, warm in nature; Return lung, stomach, large intestine channel.< < Japan hanako materia medica > >: " control conjunctival congestion bulbar conjunctiva polyp; and tire patching leaks landing; broken stagnated blood; mend fresh blood; acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, scabies; desolation, pain relieving granulation promoting, go face Shao-defect scar." < < Compendium of Materia Medica > >: " and control nasal sinusitis, epistaxis, toothache, supraorbital bone pain, large intestine constipation due to pathogenic wind, married woman's blood dizziness due to wind pathogen fortune, bleeding urine, regurgitation of food from the stomach is told food; Solution arsenic poison, snakebite, cutter arrow incised wound." function expelling pathogenic wind from the body surface, dispersing cold for relieving pain, dehumidifying are sensible, detumescence and apocenosis.Cure mainly anemofrigid cold, headache, supraorbital bone pain, toothache, eye itching lacrimation, nasal obstruction, nasal sinusitis, wet chronic diarrhea, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, pruritus scabies, the venom contained.Can improve microcirculation in human body, promote skin metabolism, and the water soluble ingredient of the Radix Angelicae Dahuricae have vasoconstrictor effects, the Coumarins composition byak-angelicin of the Radix Angelicae Dahuricae has dilating effect to coronary vasodilator.

Radix seu Caulis Jasmini lanceolarii: property is flat, and bitter in the mouth is pungent.Warm in nature, bitter in the mouth is nontoxic.Function cures mainly: expelling wind and removing dampness, promoting blood circulation and stopping pain.Dispelling the wind and dampness pathogens waist condyle pain, traumatic injury, sore, carbuncle.1. < < classification medical herbs > >: " dispelling the wind and dampness pathogens, and blood vessels pain all over the joints; Heat clearing away, controls wind syndrome of head pain." 2. in < <, traditional Chinese medicines are planted will > >: " controls traumatic injury, has and bores the deep effect of muscle: cure mainly lumbago, skelalgia etc., also have the usefulness of the middle wind and cold of boning." 3. < < Traditional Chinese Medicine in Sichuan will > >: " treats bones and muscles pain due to rheumatism, lumbago, the hematocele after loose bone is broken, and control wind syndrome of head."

Capreolus Capreolus (Linnaeus).: sweet in the mouth; Salty; Warm in nature.Return kidney channel.Function cures mainly: kidney-replenishing; Benefiting essence-blood; Bone and muscle strengthening.Main asthenia is frail; Soreness of the waist and knees; Bones and muscles pain; Sexual impotence; Infertile.

Radix Pandani Furcati: sweet light, cool.Function cures mainly: clearing away heat and promoting diuresis, diaphoresis pain relieving.The heating that cures cold, urinary tract infection, oedema due to nephritis, conjunctivitis, hepatitis, lumbago, skelalgia of rheumatism, colicky.

Fructus Chaenomelis: sour in the mouth, warm in nature, nontoxic; Return liver, spleen channel.The modern Practical Chinese medicinal > of < < >: " crude fruit liquid, controls gastric indigestion, and is nutriment, is again the agent of stimulating the secretion of milk.Ripe fruit, can sharp defecation, also can control red-white dysentery." < < food book on Chinese herbal medicine > >: " main promoting the circulation of QI, loose stagnant blood, treats painedly, separates heat stagnation." Fructus Chaenomelis has good relaxing muscles and tendons and activating QI and blood in the collateral effect, and energy removing dampness, and by dispelling the wind and dampness pathogens arthralgia pain is commonly used, muscle arteries and veins contracture person is key medicine particularly.Papaya powder can alleviate liver cell fatty degeneration and the hepatic necrosis that rat skin lower injection carbon tetrachloride causes, prevents that swelling of liver cell and balloon sample from becoming, and can promote hepatocellular reparation, and SGPT is significantly reduced.Multiple intestinal and staphylococcus are had to remarkable inhibitory action, Diplococcus pneumoniae and tubercule bacillus are also had to obvious inhibitory action.Carpaine has the effect of alleviating spasm pain, for sural spasm, has obvious therapeutical effect.

Bombyx mori L.: acrid in the mouth, sweet, warm in nature.< < Compendium of Materia Medica > >: " control and quench one's thirst, crux, and married woman's metrorrhagia, wind syndrome of head, blepharitis marginalis, goes wind dehumidifying." < < Bencao Shiyi > >: " and parching to brown, bag is contained infusing drugs in wine, goes the slow all joints of wind unsuccessful, the stupid paralysis of skin, Su Leng in abdomen, cold-blooded blood stasis, waist foot pain is cold." dispeiling pathogenic wind and removing dampness, heat clearing and blood circulation promoting.Dispelling the wind and dampness pathogens, munbness, joint is unsuccessful, the convulsion of sharply vomiting and diarrhoea, muscles and bones is unsuccessful, blood stasis, wind syndrome of head acute conjunctivitis in lumbar and pedal pain, abdomen.This product pungent and sweet flavors can be used for dispersing, can Eradicates wind, warm-dryness syndrome and leading to, and kind dehumidifying relaxing muscles and tendons again, effect relaxes, and can be used for various arthromyodynias.The alone steaming of < < prescriptions worth thousand gold > >, more presses affected part, and with dispelling the wind and dampness pathogens arthralgia pain, limbs are unsuccessful.Enter taste, the removing dampness of energy stomach function regulating, wetting goes to have loose bowels can stop, muscle arteries and veins can relax.

Lignum Pini Nodi: hardship, temperature; Enter heart channel, lung meridian.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " network of passing through, controls phlegm-fire, bones and muscles pain, arthralgia chiefly caused by damp pathogen flaccidity is soft, bone and muscle strengthening." < < Japan hanako materia medica > >: " controls foot chondromera wind." < < book on Chinese herbal medicine converges and says > >: " and Lignum Pini Nodi, temperature is dry, as sufficient knee joint muscles and bones, has wind to have wet, the acid of having a pain, the weak unable person of flaccidity, with this vertical fullying recover from an illness.If deficiency of YIN marrow is weary, blood is dry fiery person, should consider and use it." function dispeiling pathogenic wind and removing dampness, pain relieving.Cure mainly anemofrigid-damp arthralgia, severe and migratory arthralgia pain, foot numbness flaccidity is soft, traumatic pain.Lignum Pini Nodi has certain analgesia, antiinflammatory action; The acidic polysaccharose extracting shows antitumor action; The polysaccharose substance, hot water extract, the acidic extraction thing that extract all have immunocompetence.

Caulis Sinomenii: bitter, pungent; Return liver, spleen channel.< < Compendium of Materia Medica > >: " dispelling the wind and dampness pathogens multiple abscess, severe and migratory arthralgia crane knee joint, paralysis pruritus, damage skin ulcer is swollen, enters in yeast for brewing rice wine and uses." < < Tianmu Mountains of Zhejiang Province medicine plants will > >: " row water diuresis rushes down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels blood system damp and hot.Control edema caused by wind, beriberi, Fengshi Guanjie pain, facial hemiparalysis, carbuncle malignant boil." function wind-damp dispelling, the meridian dredging, diuresis.For rheumatic arthralgia, arthroncus, paralysis pruritus.Caulis Sinomenii dispersing wind and cold arthralgia chiefly caused by damp pathogen, can relaxing muscles and tendons to promote blood circulation, the sharp marrow that bonesets, thus syndrome caused by wind pathogen weakness, and the card attached undue importance to one thing to the neglect of the other by force of strength, take for a long time informal dress, make outstanding contributions greatly.Must be apt to also with Radix Angelicae Sinensis, the Fructus Lycii side of share.Sinomenine is in the test with mice electrostimulation, hot plate method and rabbit photo-thermal stimulus method, and all proof has sure analgesic activity.Sinomenium acutum total alkali is to anesthesia or anaesthesia experiment animal (dog, cat, rabbit, rat) not, and intravenous injection or gavage all have sure acute antihypertensive effect.

Resina Liquidambaris: pungent, hardship, flat; Return spleen, lung, Liver Channel.Function expelling wind and activating blood circulation, removing toxic substances pain relieving, hemostasia and promoting granulation.For carbuncle, skin ulcer rash, scrofula, toothache, arthralgia pain, paralysis, spits blood, epistaxis, spitting of blood, traumatic hemorrhage, chapped skin.Resina Liquidambaris and volatile oil experiment in vitro thereof can make Sanguis Leporis seu oryctolagi bolt contraction in length and weight (weight in wet base and dry weight) alleviate, and in body experiment, show that can obviously suppress rat suppository forms; Test tube method experiment shows obviously to improve plasmin activity, significantly improves cAMP content in platelet.Show Resina Liquidambaris and volatile oil anti thrombotic action thereof and and promote fibrinolytic and improve platelet cAMP relevant, and to point out volatile oil may be the main hemostatic compositions of Resina Liquidambaris.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold in nature, enter the heart, Liver Channel, there is the effect of blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, removing heat from blood mind calming, be mainly used in the ambition of stagnation of QI and blood, the twinge of the breast side of body, sensation of oppression over the chest with shortness of breath, abdominal distention; The menoxenia of women's disharmony between QI and blood, dysmenorrhoea amenorrhea; Stagnation of QI-blood, the symptoms such as trusted subordinate's pain, Radix Salviae Miltiorrhizae can reduce as interior fat and testis fatty around, alleviates insulin secretion and glycometabolic early stage infringement.Strengthen myocardial contraction, improve cardiac function, do not increase myocardial oxygen consumption.Coronary artery dilating, increases myocardial flow; Expansion peripheral blood vessel, blood flow increases; Cerebral blood flow declines, and improves plasmin activity; Extend, clotting time; Anticoagulant (improving cAMP level inhibition TXA2 in platelet synthesizes); Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time shorten).Radix Salviae Miltiorrhizae Tabellae is the Chinese patent medicine of blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain.The disease such as be mainly used in angina pectoris, hypertension, cervical spondylosis and feel oppressed in the heart.And the side effect reliable, Radix Salviae Miltiorrhizae Tabellae of its drug effect is little.But that can not eat is too frequent.Because long-term taking FUFANG DANSHEN PIAN may cause blood potassium content and reduce, produce hypokalemia.

Caulis Viticis Cannabifoliae: acrid in the mouth; Micro-hardship; Property is put down.Return: lung; Liver; Spleen; Stomach warp.Function cures mainly: expelling pathogenic wind from the body surface; Reducing swelling and alleviating pain.Main flu; Sore throat; Toothache; Foot gas; Skin ulcer is swollen; Burn.

Chinese mugwort in thousand: pungent, bitter, tepor.Function cures mainly: expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling, relieving cough and resolving phlegm.For anemofrigid cold, measles, Fengshi Guanjie pain, stomachache, bronchitis, pertussis, furuncle swelling toxin, mastitis.

Fructus Liquidambaris: hardship, flat; Return liver, kidney channel.The < < detailed outline > > that picks up any lost article from the road: " maple fruit, tree is like Cortex Populi dividianae, and inner circle is as honeycomb, i.e. Fructus Liquidambaris.The large energy of its property acupoints of twelve meridians that passes through, therefore < < lifesaving sea of bitterness > > harnesses the river swelling with it, can search by FUSHUI also with it." the modern Practical Chinese medicinal > of < < >: " ashing is outer for skin exudative dermatitis, anal fistula etc., has convergence, antiinflammatory, disinfective action." dispelling, collateral-activating, diuretic stimulates the menstrual flow.For arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.The property of Fructus Liquidambaris tool tonneau, function promoting the circulation of QI to alleviate the stagnation in middle-JIAO and pain relieving, clinically for abdominal distention, the disease such as not well of defecating.This product has again the effect of inducing diuresis to remove edema, for edema, can with the compatibilities such as Cortex Sclerotii Poriae, Cortex Mori, Exocarpium Benincasae.In addition, the property of this product tonneau also can catharsis milk, for stagnation of QI-blood, galactostasis.

Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat; Return liver, kidney channel.< < Japan hanako materia medica > >: " control waist knee joint soft timid cold a little less than, broken crux, evacuation of pus pain relieving, puerperal cardiac and abdominal pain blood fortune, the tire that falls, tonifying YANG." < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " control furuncle, carbuncle, apply affected part.Also can have an abortion.With Carnis Sus domestica, simmer food, energy improving eyesight." there is invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, ignite (blood) is descending, the effect of inducing diuresis for treating stranguria syndrome, the inclined to one side nourishing the liver and kidney of Radix Achyranthis Bidentatae merit, strong waist knee joint: the soreness of bones and muscles causing for deficiency of the liver and kindey, lumbocrural pain.Radix Cyathulae is with promoting blood circulation to restore menstrual flow, and wind-damp dispelling is good at: for blood stasis amenorrhea and rheumatalgia.This moral character is kind descending, and fire and the top of specially controlling inflammation are hemorrhage, therefore be usually used in the diseases such as conjunctival congestion, pharyngeal swelling, haematemesis, epistaxis of hyperactivity of deficient fire or heat in blood upper punch.The traditional Chinese medical science thinks, its property bitter but sweet flavor acid is flat, has promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, draws the descending effect of blood (fire), be usually used in treating the gynaecopathia such as amenorrhea, dysmenorrhea, menoxenia, puerperal abdonimal pain of stagnation of blood stasis, traumatic injury, the soreness of waist and knee joint of suffering from a deficiency of the kidney, weakness of the lower extremities, hematuria; dysuria, Urethra astringent pain and intimately go up the cards such as headache that inflammation causes, dizzy, haematemesis, epistaxis.

Caulis Spatholobi: nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Can relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation.Main numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea; Amenorrhea.Function: enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.This product is containing formoononetin, ononin, prunusetin., A Fuluomoxin, cajinin, licochalcone, isoliquiritigenin, tetrahydroxy chalcone derivative, Daidezin, 7-hydroxy-11,12-(methylenedioxy)coumestan, 9-O-methoxyl group coumestrol, 3,7-dihydroxy-6-melonia flavonol, epicatechin, protocatechuic acid, freidelin-3b-alcohol, b-sitosterol, daucosterol and 7-ketone group-b-sitosterol.Pharmacological action: the effect to hemopoietic system; Effect to blood coagulation, fibrinolytic; Suppress heart and the effect of reducing blood pressure; Antitumaous effect; Adjusting to lipid metabolism.

Squama Manis: salty in the mouth, cold nature; Return liver, stomach warp.< < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " control mange carbuncle poison, dispelling the stagnated QI promoting the circulation of blood, chest and diaphragm expands against gas, controls bladder hernia pain." < < Compendium of Materia Medica > >: " and except intermittent fever due to phlegm cold and heat, the tetanic pain of migratory arthralgia, qualcomm meridian, lower milk, subduing inflammation, evacuation of pus blood, sensible parasite killing." blood circulation promoting and dispersing pathogen accumulation, the stimulating milk secretion of stimulating the menstrual flow, eliminating carbuncle is burst hard.Main blood stasis amenorrhea, lump in the abdomen, rheumatic arthralgia, agalactia, carbuncle, scrofula.Squama Manis has preferably catharsis milk effect, for galactostasis in puerperal, can single be end, and yellow wine takes.For strengthening stimulating milk secretion effect; If puerperal, QI and blood deficiency, milk were rare.Squama Manis has the effect of detumescence and apocenosis, and person disappears to make carbuncle not become pus, and suppuration person's speed is burst.

 

Embodiment 1 emplastrum

The embodiment of the present invention provides a kind of Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness, described Chinese medicine composition is comprised of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 21 weight portions, Paphiopedilum parishii(Rchb. F.) Pfitz 20 weight portions, Rhizoma Et Radix Notopterygii 22 weight portions, Radix Angelicae Pubescentis 23 weight portions, the Radix Angelicae Dahuricae 16 weight portions, Radix seu Caulis Jasmini lanceolarii 20 weight portions, Capreolus Capreolus (Linnaeus). 20 weight portions, Radix Pandani Furcati 23 weight portions, Fructus Chaenomelis 23 weight portions, Bombyx mori L. 17 weight portions, Lignum Pini Nodi 20 weight portions, Caulis Sinomenii 21 weight portions, Resina Liquidambaris 23 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Caulis Viticis Cannabifoliae 18 weight portions, Chinese mugwort 22 weight portions in thousand, Fructus Liquidambaris 17 weight portions, Radix Achyranthis Bidentatae 17 weight portions, Caulis Spatholobi 26 weight portions and Squama Manis 23 weight portions.

The Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness is emplastrum, and its preparation method comprises the following steps:

A, the raw medicinal material taking by weight add in the ethanol that the determining alcohol of 5 times of raw medicinal material gross weights is 85%, heating and refluxing extraction 3 times, and each 4 hours, extracting solution is merged standing, obtain extracting solution one;

B, the medicinal residues that in step a, ethanol extraction is crossed are added to water heating and refluxing extraction 2 times, each 2 hours, extracting solution is merged standing, obtain extracting solution two;

C, extracting solution one and extracting solution two merged, in suction concentrating under reduced pressure tank, be decompressed to 0.06MPa, when being concentrated into temperature and being 75 ℃, relative density is 1.03, the extractum of temperature to 83 ℃; Continue the concentrated emplastrum of modulating to obtain of heating.

 

Embodiment 2 capsules

The Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness according to claim 1, it is characterized in that, described Chinese medicine composition is comprised of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 30 weight portions, Paphiopedilum parishii(Rchb. F.) Pfitz 25 weight portions, Rhizoma Et Radix Notopterygii 16 weight portions, Radix Angelicae Pubescentis 16 weight portions, the Radix Angelicae Dahuricae 21 weight portions, Radix seu Caulis Jasmini lanceolarii 25 weight portions, Capreolus Capreolus (Linnaeus). 25 weight portions, Radix Pandani Furcati 16 weight portions, Fructus Chaenomelis 30 weight portions, Bombyx mori L. 25 weight portions, Lignum Pini Nodi 14 weight portions, Caulis Sinomenii 24 weight portions, Resina Liquidambaris 31 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Caulis Viticis Cannabifoliae 25 weight portions, Chinese mugwort 12 weight portions in thousand, Fructus Liquidambaris 12 weight portions, Radix Achyranthis Bidentatae 10 weight portions, Caulis Spatholobi 16 weight portions and Squama Manis 31 weight portions.

The above-mentioned dosage form that is used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness is capsule, and its preparation method comprises the following steps:

A, according to parts by weight, take Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis, add the water soaking 3 hours of 4 times of amounts of above-mentioned four kinds of raw medicinal material mixture, extract the volatile oil of 2 hours, collect volatile oil, medicinal liquid filters, and medicinal residues are standby;

B, by the medicinal residues in step a with remain other raw medicinal materials and mix, add alcoholic degree and be in 75% ethanol, soak 1-2 hour, extract twice, each 2 hours, adding for the first time amount of alcohol was 4 times of mixture, adding for the second time amount of alcohol is 7 times of mixture, and merge extractive liquid, filters; Above two filtered solutions merge to filter, and 1.30 precipitate with ethanol when filtered solution is evaporated to relative density and is 88 ℃, adjust concentration of alcohol to 73%, get supernatant concentration to relative density 1.13-1.50 while being 88 ℃, obtain extractum;

C, get the extractum that step b obtains, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for 3% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.Every capsules 0.4g.

 

Pharmacology pharmacodynamic experiment:

1, cumulative toxicity test report

Test method: select 20 healthy mices, female, male each 10, the capsule of the embodiment of the present invention 2 of take is object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.

2, acute toxicity test: the capsule of the embodiment of the present invention 2 of take is object, gives white mouse large enteral dispensing, observes 7 for 150 times of clinical consumption per day.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out to irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.

3, according to Ministry of Public Health < < cosmetics health standard > > (2002) second portion " acute dermal toxicity test " test method(s) of once limiting the quantity of, 20 of SD rats, male and female half and half, body weight 90g～180g, the emplastrum that the embodiment of the present invention 1 is obtained, one time percutaneous is smeared 5000mg/kg body weight dosage, observe 15 days, do not find obvious poisoning symptom, nothing death, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.

4, according to 6.3 joints in Ministry of Public Health < < cosmetics health standard > > (2002) second portion " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg, the emplastrum of getting the 0.5g embodiment of the present invention 1 directly spreads upon on the skin of animal left side (opposite side in contrast), adopt blocking test, 4 hours application time, after off-test, use the residual tested material of warm water washing, 1h after removing tested material, 24h, 48h and 72h observe respectively the dermoreaction of the tested district of animal and check plot, top average is " 0 ", judge that these product are to animal skin nonirritant.

5, get 18 of healthy albino guinea-pigs, body weight 250-300g, male and female dual-purpose, rejects both sides dorsal body setae before test, and every side 3 * 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The emplastrum 0.1g that gets the embodiment of the present invention 1 is applied to unhairing district, back, the next day 1 time, totally 3 times.In last, contact latter 14 days, at back the same area, smear this product 0.1g, after 6h, remove after medicine and at once observe, and in 24,48,72h observes and has or not anaphylaxis.Blank group is used same method to excite with positive controls and is contacted and observe.Result of the test: localized erythema and slight edema appear in positive controls animal skin after 1 hour in sensitization, within 24 hours, symptoms of allergic increases the weight of, and there is scleroma to form, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.

 

Clinical trial

1, data and method

1.1 physical data: during selecting in May, 2010-2012 year July, the lumbago due to pathogenic wind-dampness patient of diagnosis and treatment is totally 450 examples, all meets after diagnosing the diagnostic criteria of lumbago due to pathogenic wind-dampness: waist is weighing, aching, tired after or overcast and rainy increasing the weight of, fine day or warmer climate take a turn for the better; The waist active receiving of bending forward and backward pins down, and sitting standing for a long time can not; Moving tired weak, affected part is afraid of cold; Pale tongue, tongue is greasy in vain, and arteries and veins scholar is slow.Wherein, male 189 examples, female's 261 examples, age 30-45 year person 76 examples, age 46-55 year person 134 examples, age 56-65 year person 155 examples, 66 years old above person's 85 example.Clinical manifestation is: lumbago, and waist is sent out heavy, and as there being weight tenesmus, tired rear or overcast and rainy increasing the weight of, takes a turn for the better when fine day or warmer climate, for a long time sitting; Fatiguability is weak, and whole body is listless and aching heavy, and affected part is afraid of cold.Choose 420 routine patients, be divided at random four groups, be respectively treatment group 1-3 and matched group, every group of 105 routine patients.Four groups of patients comparing difference not statistically significant aspect age, sex, state of an illness weight, has comparability, and according to the weight treatment of the state of an illness.

1.2 criterion of therapeutical effect

Recovery from illness disappears completely for symptom, and waist functional rehabilitation is normal; Effectively for symptom, substantially disappear, otherwise function is recovered substantially normally without sense of discomfort; Transfer symptom to well and alleviate, waist function is improved; Invalid is that treatment front and back symptom and waist function are not any change.

1.3 Therapeutic Method and therapeutic effect

1.3.1 treatment group 1-2 is used respectively the Chinese medicine composition of the different preparations of embodiment of the present invention 1-2 to treat, and treatment group 3 is used the Chinese medicine composition of the embodiment of the present invention 1 and embodiment 2 to treat simultaneously:

(1) treatment group 1:105 example patient uses the emplastrum of the embodiment of the present invention 1, clean after waist, by emplastrum beach on preservative film or gauze, with medical adhesive tape or binder, fix, one day twice, use 3-6 hour at every turn, use continuously 10-15 days, drug withdrawal is further consultation again after one week.Statistics finds that 65 routine patients all fully recover, and 20 routine patients are effective, and 18 routine patients are effective, and 2 routine patients are invalid.During treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, recovery from illness patient is all without any recurrence symptom.

(2) treatment group 2:105 example patient uses the capsule of the embodiment of the present invention 2, and three times on the one, once take 2-4 grain, use continuously 10-15 days, drug withdrawal is further consultation again after one week.Statistics finds that 64 routine patients all fully recover, and 26 routine patients are effective, and 13 routine patients are effective, and 2 routine patients are invalid.During treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, recovery from illness patient is all without any recurrence symptom.

(3) treatment group 3:105 example patient uses the emplastrum of the embodiment of the present invention 1 and the capsule of embodiment 2 simultaneously, clean after waist, by emplastrum beach on preservative film or gauze, with medical adhesive tape or binder, fix, once-a-day, use 3-6 hour at every turn, capsule three times on the one, once take 2-4 grain, use continuously 8-12 days, drug withdrawal is further consultation again after one week.Statistics finds that 78 routine patients all fully recover, and 17 routine patients are effective, and 10 routine patients are effective.During treatment, do not find other side effect that medicine brings, follow up a case by regular visits to half a year, recovery from illness patient is all without any recurrence symptom.

1.3.2 the patient of matched group uses nonsteroidal anti-inflammatory agent ibuprofen 400mg, every day three times, and each two, to use continuously 15 days, drug withdrawal is further consultation again after one week, and statistics is found 38 routine patient's recoveries from illness, and 19 routine patients are effective, and 42 routine patients take a turn for the better, and 6 routine patients are invalid.Follow up a case by regular visits to half a year, statistics recurs after finding wherein to fully recover and having 6 routine patient's drug withdrawals in patient; During treating, there are 7 routine patients to occur the side effect such as stomachache, dyspepsia.

Known by above-mentioned clinical trial: compare with traditional Western medicine for the treatment of lumbago due to pathogenic wind-dampness, the Chinese medicine composition of embodiment of the present invention 1-2 has advantages of that healing time is short, cures rear difficult recurrence and have no side effect.

 

2, concrete case

Case 1: Lin, man, 57 years old, lumbago, waist is sent out heavy, and as there being weight tenesmus, tired rear or overcast and rainy increasing the weight of, takes a turn for the better when fine day or warmer climate, for a long time sitting; Fatiguability is weak, and whole body is listless and aching heavy, and affected part is afraid of cold, and above-mentioned symptom continued about half a year.Use the emplastrum treatment of the embodiment of the present invention 1, clean after waist, emplastrum beach, on preservative film or gauze, is fixed with medical adhesive tape or binder, one day twice, use 4 hours at every turn, to use continuously 12 days, drug withdrawal is further consultation again after one week.Symptom all disappears, and waist functional rehabilitation is not found other side effect that medicine brings during treatment, follow up a case by regular visits to half a year, without any recurrence symptom.

Case 2: Chen, female, 67 years old, lumbago, waist is sent out heavy, and tired rear or overcast and rainy increasing the weight of, takes a turn for the better when fine day or warmer climate, for a long time sitting; Fatiguability is weak, and whole body is listless and aching heavy, and affected part is afraid of cold, pale tongue, and tongue is greasy in vain, and arteries and veins scholar is slow.Use the emplastrum of the embodiment of the present invention 1 and the treatment of the capsule of embodiment 2 simultaneously, clean after waist, by emplastrum beach on preservative film or gauze, with medical adhesive tape or binder, fix, one day twice, use 3 hours at every turn, capsule three times on the one, once take 2-4 grain, use continuously 10 days, drug withdrawal is further consultation again after one week.Symptom all disappears, and waist functional rehabilitation is not found other side effect that medicine brings during treatment, follow up a case by regular visits to half a year, without any recurrence symptom.

 

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims (9)

1. the Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Radix seu Caulis Jasmini lanceolarii, Capreolus Capreolus (Linnaeus)., Radix Pandani Furcati, Fructus Chaenomelis, Bombyx mori L., Lignum Pini Nodi, Caulis Sinomenii, Resina Liquidambaris, Radix Salviae Miltiorrhizae, Caulis Viticis Cannabifoliae, Chinese mugwort, Fructus Liquidambaris, Radix Achyranthis Bidentatae, Caulis Spatholobi and Squama Manis in thousand.

2. the Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness according to claim 1, it is characterized in that, described Chinese medicine composition is comprised of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 10-30 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 15-25 weight portion, Rhizoma Et Radix Notopterygii 16-31 weight portion, Radix Angelicae Pubescentis 16-31 weight portion, Radix Angelicae Dahuricae 11-21 weight portion, Radix seu Caulis Jasmini lanceolarii 16-25 weight portion, Capreolus Capreolus (Linnaeus). 16-25 weight portion, Radix Pandani Furcati 16-30 weight portion, Fructus Chaenomelis 16-30 weight portion, Bombyx mori L. 12-25 weight portion, Lignum Pini Nodi 14-25 weight portion, Caulis Sinomenii 16-24 weight portion, Resina Liquidambaris 16-31 weight portion, Radix Salviae Miltiorrhizae 16-25 weight portion, Caulis Viticis Cannabifoliae 12-25 weight portion, Chinese mugwort 12-31 weight portion in thousand, Fructus Liquidambaris 12-20 weight portion, Radix Achyranthis Bidentatae 10-21 weight portion, Caulis Spatholobi 16-31 weight portion and Squama Manis 16-31 weight portion.

3. the Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness according to claim 1 and 2, it is characterized in that, described Chinese medicine composition is comprised of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 15-25 weight portion, Paphiopedilum parishii(Rchb. F.) Pfitz 17-23 weight portion, Rhizoma Et Radix Notopterygii 18-27 weight portion, Radix Angelicae Pubescentis 18-26 weight portion, Radix Angelicae Dahuricae 13-18 weight portion, Radix seu Caulis Jasmini lanceolarii 18-22 weight portion, Capreolus Capreolus (Linnaeus). 19-21 weight portion, Radix Pandani Furcati 19-26 weight portion, Fructus Chaenomelis 19-26 weight portion, Bombyx mori L. 15-22 weight portion, Lignum Pini Nodi 18-22 weight portion, Caulis Sinomenii 19-23 weight portion, Resina Liquidambaris 19-27 weight portion, Radix Salviae Miltiorrhizae 19-23 weight portion, Caulis Viticis Cannabifoliae 15-22 weight portion, Chinese mugwort 18-26 weight portion in thousand, Fructus Liquidambaris 15-20 weight portion, Radix Achyranthis Bidentatae 15-21 weight portion, Caulis Spatholobi 23-31 weight portion and Squama Manis 20-27 weight portion.

4. according to the Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness described in claim 1-3 any one, it is characterized in that, described Chinese medicine composition is comprised of the raw medicinal material of following parts by weight: Ramulus Cinnamomi 21 weight portions, Paphiopedilum parishii(Rchb. F.) Pfitz 20 weight portions, Rhizoma Et Radix Notopterygii 22 weight portions, Radix Angelicae Pubescentis 23 weight portions, the Radix Angelicae Dahuricae 16 weight portions, Radix seu Caulis Jasmini lanceolarii 20 weight portions, Capreolus Capreolus (Linnaeus). 20 weight portions, Radix Pandani Furcati 23 weight portions, Fructus Chaenomelis 23 weight portions, Bombyx mori L. 17 weight portions, Lignum Pini Nodi 20 weight portions, Caulis Sinomenii 21 weight portions, Resina Liquidambaris 23 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Caulis Viticis Cannabifoliae 18 weight portions, Chinese mugwort 22 weight portions in thousand, Fructus Liquidambaris 17 weight portions, Radix Achyranthis Bidentatae 17 weight portions, Caulis Spatholobi 26 weight portions and Squama Manis 23 weight portions.

5. a preparation method for the Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness as described in claim 1-4 any one, is characterized in that, the dosage form of described Chinese medicine composition is emplastrum, and described preparation method comprises the following steps:

A, according to parts by weight, take all raw medicinal materials, put into ethanol heating and refluxing extraction 3 times, merge three extracting solution and obtain extracting solution one;

B, again by the medicinal residues of ethanol extraction in step a, add water heating and refluxing extraction 2 times, merge 2 extracting solution and obtain extracting solution two;

C, extracting solution one and extracting solution two merged, concentrated, obtain extractum, the concentrated modulation of heating.

6. the preparation method that is used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness according to claim 5, it is characterized in that, in described step a, the raw medicinal material taking by weight adds in the ethanol that the determining alcohol of 5 times of raw medicinal material gross weights is 85%, heating and refluxing extraction 3 times, each 2-5 hour, merges extracting solution standing, obtains extracting solution one.

7. the preparation method that is used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness according to claim 5, is characterized in that, in described step b, the medicinal residues that in step a, ethanol extraction is crossed are added to water heating and refluxing extraction 2 times, each 1-3 hour, merges extracting solution standing, obtains extracting solution two.

8. the preparation method that is used for the treatment of the Chinese medicine composition of lumbago due to pathogenic wind-dampness according to claim 5, it is characterized in that, in described step c, extracting solution one and extracting solution two are merged, in suction concentrating under reduced pressure tank, be decompressed to 0.03-0.09MPa, when being concentrated into temperature and being 60-90 ℃, relative density is 1.03, the extractum that temperature to 75 is ℃-92 ℃; Continue the concentrated emplastrum of modulating to obtain of heating.

9. a preparation method for the Chinese medicine composition that is used for the treatment of lumbago due to pathogenic wind-dampness as described in claim 1-4 any one, is characterized in that, the dosage form of described Chinese medicine composition is capsule, and described preparation method comprises the following steps:

A, according to parts by weight, take Ramulus Cinnamomi, Paphiopedilum parishii(Rchb. F.) Pfitz, Rhizoma Et Radix Notopterygii and Radix Angelicae Pubescentis, add above-mentioned four kinds of water soaking 1-3 hour that raw medicinal material mixture 3-4 doubly measures, extract the volatile oil of 1-3 hour, collect volatile oil, medicinal liquid filters, and medicinal residues are standby;

B, by the medicinal residues in step a with remain other raw medicinal materials and mix, add in the ethanol that alcoholic degree is 75-80%, soak 1-2 hour, extract twice, each 2 hours, adding for the first time amount of alcohol was 4 times of mixture, adding for the second time amount of alcohol is 7 times of mixture, and merge extractive liquid, filters; Above two filtered solutions merge to filter, and when filtered solution is evaporated to relative density and is 88 ℃, 1.13-1.50 precipitate with ethanol, adjusts concentration of alcohol to 73-96%, get supernatant concentration to relative density 1.13-1.50 while being 88 ℃, obtain extractum;

C, get the extractum that step b obtains, the volatile oil and the vegetable oil that add step a to obtain, the addition of vegetable oil accounts for the 2-5% of extractum and volatile oil gross mass, mix, with colloid mill, grind 10 minutes, constantly stir, be cooled to room temperature, described Chinese medicine composition is incapsulated in housing, obtain described capsule.