CN104644937A - Spray for treating vasospasm and preparation method of spray - Google Patents

Abstract

The invention provides a spray for treating vasospasm and a preparation method of the spray. The spray is prepared from the following medicinal materials: dried radix rehmanniae, radix glehniae, wolfberry, dogwood, spina date seeds, hawthorns, selfheal, pinellia ternate, pericarpium citri reticulatae, snakegourd peel, rhizoma corydalis, entada phaseoloides, herba erigerontis, nidus vespae, garden balsam stem, hemiphragma heterophyllum, cornus hemsleyi, viola arcuata, szemao premna bark, gynura divaricata, thelephora vialis, ass meat, bilobate grewia, tapioca flour and canis familiaris. The spray is used for relaxing tendons to treat vasospasm as a treatment principle, and is capable of nourishing yin, warming yang, benefiting qi and regulating the liver; meanwhile, the human immunity can be improved; the spray has the characteristics of being purely natural, free of poison or harm, safe, convenient, complete in function, and small in toxic or side effect; the preparation technology is simple and convenient; the spray is convenient to mediate, relatively good in curative effect, relatively good in tolerance, and easy to accept; and a medicine is easy to prepare and low in cost.

Description

One treats angiospastic spray and preparation method thereof

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly one treats angiospastic spray and preparation method thereof.

Background technology

Vasospasm is the abnormal contraction state within a period of time that Digital arteries causes because of extraneous factor or the factor of self.Cerebral vasospasm patient has repeatedly the symptoms such as headache, dizziness, hypomnesis, emotional maladjustment, sleep disorder, should note rational diet, moderate exercise, smoking cessation limit wine and maintain one's mental balance.Vasospasm is by Drug therapy and surgical operation therapy.

Brief introduction: the arteriosclerosis plaque of internal carotid artery or Vertebro-basilar System makes lumen of vessels narrow and occur blood flow eddy current.When eddy current accelerates, blood vessel wall is stimulated to cause vasospasm and occur transient ischemic attack, transference cure when vortex slows down.But some scholars think due to the particularity of cerebral vessel structures, not easily spasm occur.Exceed several scholar and think that vasospasm can betide internal carotid artery and circle of Willis undoubtedly, the visible large artery trunks spasm of cerebral angiography; Subarachnoid hemorrhage can cause widely with focal cerebral vasospasm; When operating the large artery trunks of brain during cerebral operations, the caliber of arteries visible significantly attenuates.Therefore under the hypertension continued, local damage or atomic stimulation, also can cause cerebral vasospasm, and cause transient ischemic attack.

Treatment: one, etiological treatment: search reason and carry out active treatment, especially should strengthen the control to atherosclerosis etc.Two, Drug therapy: 1. cerebral vasodilator and expander early application obviously can reduce and stop TIA clinical episodes.Doubly he pyridine 20mg can be selected to add 5% glucose 500ml, or low molecular dextran or quiet of 706 plasma substitute 500ml.Troxerutin, flunarizine etc. also may have certain effect.2. anti-platelet aggregation agent can reduce the generation of microemboli.As do not commonly not used aspirin for treatment 50mg--300mg every day without Peptic Ulcers or hemorrhage person not etc., majority is thought and to be advisable with smaller dose, if long-term taking dosage also can reduce.Persantin (25mg every day 3 times) and aspirin share and can play synergism, and can reduce aspirin dose.As patient should not with aspirin or the undesirable person of Aspirin curative effect, thiophene chloropyridine (Ticlopidine200--250mg every day 1--2 time) can be used instead or make every effort to overcome bolt (ticlid) 250mg, every day 1 time), in treatment, all should be noted the control strengthened the toxic and side effects such as hemorrhage.3. anticoagulant therapy is to showing effect frequently, being in a bad way and successively increasing the weight of, and without obvious anticoagulant therapy taboo person, carrying out anticoagulant therapy early all has positive effect to deduction and exemption outbreak and prevention cerebral infarction.Conventional heparin 12500U to add in 5% G/NS slowly quiet, and first day can oral neodicoumarin 300mg or dicoumarol 100--200mg or warfarin 4--6mg simultaneously.Check prothrombin time and mobility every day, survey weekly once after stable, to adjust oral dose, require that venous thrombosis time dimension is held in 20--30 minute, prothrombing mobility is at 15--25%.Later maintenance dose is neodicoumarin 150--225mg, dicoumarol 25--75mg or warfarin 2--4mg.Treatments period answers attention control hemorrhage complication.Drug withdrawal should decrement gradually, to avoid " rebound effect ".Because this treatment is difficult to Charge control, and hemorrhage complication is many, current domestic less employing.4. calcium antagonist optionally can act on the calcium channel of cerebrovascular smooth muscle, stops calcium ion to be flowed in cell by extracellular, has and prevents cerebral vasospasm, blood vessel dilating, increase cerebral blood flow and maintain the effects such as erythrocyte deformability.General multiselect flunarizine 5--10mg, once a day.5. other is as extracorporeal counterpulsation, ultraviolet light quantum therapy and hemodilution method, and the blood circulation promoting and blood stasis dispelling such as Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, dredge the meridian passage Chinese medicine also can be selected.Three, surgical operation therapy: intravascular radiography confirms have cervical region large artery trunks to have obvious stenosis or Occlusion, curative effect of medication is poor, patient's ordinary circumstance allows, and the person of having ready conditions can consider the outer angiostomy of internal carotid artery endarterectomy, stentplacement art or intracranial cranium.To elimination micro-embolization, improve cerebral blood flow and set up Doppler flow mapping and all have certain curative effect.Owing to not effecting a radical cure method, and surgical indication and effect are not yet affirmed, domestic still less employing.

Western medicine: easily recur, and have bleeding tendency more, be unfavorable for the life-time service of patient.

Summary of the invention

In order to solve the problems of the technologies described above, the invention provides and a kind ofly treat spray of blood spasm and preparation method thereof, the present invention is Therapeutic Principle in treatment vasospasm with relaxing muscles and tendons, holds concurrently with yin nourishing, warming YANG, QI invigorating, tune liver.Meanwhile, can improve the immunity of people, have pure natural property in treatment vasospasm, nonhazardous, safe ready, complete function, processing technology are easy, the feature that toxic and side effects is little, and convenient drug administration, curative effect is better, and toleration is better, is easy to accept; Medicament is easy to manufacture, with low cost.

The invention provides a kind of spray for the treatment of blood spasm, wherein, described spray is obtained by following raw medicinal material: the Radix Rehmanniae, Radix Glehniae, Fructus Lycii, Fructus Corni, Semen Ziziphi Spinosae, Fructus Crataegi, Spica Prunellae, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Pericarpium Trichosanthis, Rhizoma Corydalis, Caulis Entadae, Herba Erigerontis, Nidus Vespae, Herba speranskiae tuberculatae, Herba hemipharagmatis heterophylli, red large-leaved dogwood, thunderclap pasture and water, Cortex Premnae szemaoensis Radicis, Radix et Rhizoma Gynurae divaricatae, lotus throne lead fungi, Carnis Equi Asini, Radix grewiae bilobae, Amylum Trapae, Testis et Pentis Canis.

Wherein, described spray is obtained by the raw medicinal material of following weight portion: Radix Rehmanniae 20-25 weight portion, Radix Glehniae 10-13 weight portion, Fructus Lycii 8-12 weight portion, Fructus Corni 10-12 weight portion, Semen Ziziphi Spinosae 10-20 weight portion, Fructus Crataegi 9-13 weight portion, Spica Prunellae 6-11 weight portion, Rhizoma Pinelliae 4-9 weight portion, Pericarpium Citri Reticulatae 10-13 weight portion, Pericarpium Trichosanthis 20-30 weight portion, Rhizoma Corydalis 9-12 weight portion, Caulis Entadae 15-25 weight portion, Herba Erigerontis 10-14 weight portion, Nidus Vespae 2-5 weight portion, Herba speranskiae tuberculatae 10-15 weight portion, Herba hemipharagmatis heterophylli 10-20 weight portion, red large-leaved dogwood 10-20 weight portion, thunderclap pasture and water 15-20 weight portion, Cortex Premnae szemaoensis Radicis 20-25 weight portion, Radix et Rhizoma Gynurae divaricatae 15-24 weight portion, lotus throne lead fungi 5-9 weight portion, Carnis Equi Asini 6-11 weight portion, Radix grewiae bilobae 12-20 weight portion, Amylum Trapae 10-14 weight portion, Testis et Pentis Canis 4-7 weight portion.

Wherein, bamboo grove clouds are also comprised, Herba Syneilesis Aconitifoliae, Cortex alni nepalensis, ground is your grass, and described spray is obtained by the raw medicinal material of following weight portion: Radix Rehmanniae 20-25 weight portion, Radix Glehniae 10-13 weight portion, Fructus Lycii 8-12 weight portion, Fructus Corni 10-12 weight portion, Semen Ziziphi Spinosae 10-20 weight portion, Fructus Crataegi 9-13 weight portion, Spica Prunellae 6-11 weight portion, Rhizoma Pinelliae 4-9 weight portion, Pericarpium Citri Reticulatae 10-13 weight portion, Pericarpium Trichosanthis 20-30 weight portion, Rhizoma Corydalis 9-12 weight portion, Caulis Entadae 15-25 weight portion, Herba Erigerontis 10-14 weight portion, Nidus Vespae 2-5 weight portion, Herba speranskiae tuberculatae 10-15 weight portion, Herba hemipharagmatis heterophylli 10-20 weight portion, red large-leaved dogwood 10-20 weight portion, thunderclap pasture and water 15-20 weight portion, Cortex Premnae szemaoensis Radicis 20-25 weight portion, Radix et Rhizoma Gynurae divaricatae 15-24 weight portion, lotus throne lead fungi 5-9 weight portion, Carnis Equi Asini 6-11 weight portion, Radix grewiae bilobae 12-20 weight portion, Amylum Trapae 10-14 weight portion, Testis et Pentis Canis 4-7 weight portion, bamboo grove clouds 10-20 weight portion, Herba Syneilesis Aconitifoliae 13-20 weight portion, Cortex alni nepalensis 8-12 weight portion, the expensive careless 7-12 weight portion in ground.

Wherein, described spray is obtained by the raw medicinal material of following weight portion: the Radix Rehmanniae 23 weight portion, Radix Glehniae 12 weight portion, Fructus Lycii 10 weight portion, Fructus Corni 11 weight portion, Semen Ziziphi Spinosae 15 weight portion, Fructus Crataegi 10 weight portion, Spica Prunellae 8 weight portion, the Rhizoma Pinelliae 5 weight portion, Pericarpium Citri Reticulatae 11 weight portion, Pericarpium Trichosanthis 25 weight portion, Rhizoma Corydalis 10 weight portion, Caulis Entadae 18 weight portion, Herba Erigerontis 12 weight portion, Nidus Vespae 3 weight portion, Herba speranskiae tuberculatae 12 weight portion, Herba hemipharagmatis heterophylli 14 weight portion, red large-leaved dogwood 16 weight portion, thunderclap pasture and water 17 weight portion, Cortex Premnae szemaoensis Radicis 22 weight portion, Radix et Rhizoma Gynurae divaricatae 18 weight portion, lotus throne lead fungi 7 weight portion, Carnis Equi Asini 8 weight portion, Radix grewiae bilobae 17 weight portion, Amylum Trapae 12 weight portion, Testis et Pentis Canis 5 weight portion.

Wherein, described spray is obtained by the raw medicinal material of following weight portion: the Radix Rehmanniae 25 weight portion, Radix Glehniae 12 weight portion, Fructus Lycii 9 weight portion, Fructus Corni 11 weight portion, Semen Ziziphi Spinosae 14 weight portion, Fructus Crataegi 10 weight portion, Spica Prunellae 7 weight portion, the Rhizoma Pinelliae 7 weight portion, Pericarpium Citri Reticulatae 12 weight portion, Pericarpium Trichosanthis 22 weight portion, Rhizoma Corydalis 9 weight portion, Caulis Entadae 17 weight portion, Herba Erigerontis 12 weight portion, Nidus Vespae 4 weight portion, Herba speranskiae tuberculatae 13 weight portion, Herba hemipharagmatis heterophylli 14 weight portion, red large-leaved dogwood 15 weight portion, thunderclap pasture and water 18 weight portion, Cortex Premnae szemaoensis Radicis 22 weight portion, Radix et Rhizoma Gynurae divaricatae 17 weight portion, lotus throne lead fungi 7 weight portion, Carnis Equi Asini 8 weight portion, Radix grewiae bilobae 16 weight portion, Amylum Trapae 12 weight portion, Testis et Pentis Canis 5 weight portion, bamboo grove clouds 13 weight portion, Herba Syneilesis Aconitifoliae 17 weight portion, Cortex alni nepalensis 9 weight portion, expensive careless 9 weight portions in ground.

For solving the problems of the technologies described above, present invention also offers the preparation method of described spray, wherein, its preparation method comprises the following steps:

The first step: the raw medicinal material Radix Rehmanniae, Radix Glehniae, Fructus Lycii, Fructus Corni are passed through according to proportioning and is ground into 200-250 object powder;

Second step: be mixed in proportion by remaining each raw medicinal material weight portion, stirs and pulverizes, add the 2-4 times of water relative to crude drug quality sum, decoct 1-2 hour, decoction liquor is filtered, and filtering residue adds relative to crude drug quality sum 1-3 times of water again, again decoct 1.5-2 hour, decoction liquor is filtered, and is merged by filtrate, adds the active carbon of 0.1-0.5 times amount, boil 50-80 minute, after natural cooling, through centrifugal, sucking filtration, obtain filtrate;

3rd step: the filtrate mixing that the powder first step obtained and second step obtain, and through purification twice, obtain purification liquid, heating is concentrated into the medicinal liquid that concentration is 1g/ml-5g/ml;

4th step: get described medicinal liquid 15ml, adds 0.1-0.4ml tween 80,30-90mg sodium sulfite wherein successively, injects water to 100ml after mix homogeneously, and with sodium hydroxide adjust pH to 6.6-6.8, finally be sub-packed in cillin bottle, after boiling water bath heat sterilization, obtain spray.

For solving the problems of the technologies described above, the present invention also provides one to treat angiospastic medicine, and the dosage form of medicine can also be: Oral preparation has: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, honey pill agent, syrup, powder sublimed preparation, solution, spray; External preparation has: spray, dropping liquid agent, tincture, suppository, plaster and patch.

The invention has the beneficial effects as follows: the present invention is Therapeutic Principle treating vasospasm with relaxing muscles and tendons, holds concurrently with yin nourishing, warming YANG, QI invigorating, tune liver.Meanwhile, the immunity of people can be improved, there is pure natural property in treatment vasospasm, nonhazardous, safe ready, complete function, processing technology are easy, the feature that toxic and side effects is little, and convenient drug administration, curative effect is better, and curative effect is fast, not easily recur, and toleration is better, is easy to accept; Medicament is easy to manufacture, with low cost.

Detailed description of the invention

It take relaxing muscles and tendons as Therapeutic Principle that the present invention treats vasospasm, holds concurrently with yin nourishing, warming YANG, QI invigorating, tune liver.Obtained by following raw medicinal material: the Radix Rehmanniae, Radix Glehniae, Fructus Lycii, Fructus Corni, Semen Ziziphi Spinosae, Fructus Crataegi, Spica Prunellae, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Pericarpium Trichosanthis, Rhizoma Corydalis, Caulis Entadae, Herba Erigerontis, Nidus Vespae, Herba speranskiae tuberculatae, Herba hemipharagmatis heterophylli, red large-leaved dogwood, thunderclap pasture and water, Cortex Premnae szemaoensis Radicis, Radix et Rhizoma Gynurae divaricatae, lotus throne lead fungi, Carnis Equi Asini, Radix grewiae bilobae, Amylum Trapae, Testis et Pentis Canis.Also comprise bamboo grove clouds, Herba Syneilesis Aconitifoliae, Cortex alni nepalensis, your grass.

Wherein, the Radix Rehmanniae, Fructus Lycii, Fructus Corni, Semen Ziziphi Spinosae, Caulis Entadae, Herba Erigerontis, Nidus Vespae, Herba speranskiae tuberculatae, Herba hemipharagmatis heterophylli, red large-leaved dogwood, thunderclap pasture and water, Cortex Premnae szemaoensis Radicis, Radix et Rhizoma Gynurae divaricatae, lotus throne lead fungi, bamboo grove clouds, Herba Syneilesis Aconitifoliae, Cortex alni nepalensis, your grass nourish whole body cloudy liquid, relaxing muscles and tendons spasmolytic; The righting of Radix Glehniae supplementing QI and nourishing YIN; Fructus Corni, Semen Ziziphi Spinosae, Spica Prunellae, Rhizoma Corydalis, Testis et Pentis Canis liver nourishing the moon, positive, the soothing the liver network of warming the liver, tune irritability, adjust the sea of blood, support venation; The Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Pericarpium Trichosanthis damp eliminating reduce phlegm; Rhizoma Corydalis, blood circulation promoting and blood stasis dispelling, eliminating blood stasis to promote regeneration of blood; Fructus Crataegi function of spleen and stomach regulating mechanism of qi; Carnis Equi Asini, Radix grewiae bilobae, the yang-energy of Amylum Trapae replenishing vital QI with drugs of warm nature whole body, emergency dredging collateral.Each medical material scientific compatibility, realizes angiospastic treatment.

The pharmacology of each medical material is as follows:

The Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup except cold and heat and gather, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.The Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in the diseases such as treatment hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.By by the Radix Rehmanniae with Fructus Amomi, wine, Pericarpium Citri Reticulatae for adjuvant, repeatedly steam and shine to color blackening, quality softness is namely in order to Radix Rehmanniae Preparata, and the LIUWEI DIHUANG WAN having Radix Rehmanniae Preparata to make, be exactly famous the kidney invigorating good medicine, the clinical treatment being also usually used in the diseases such as chronic nephritis, hypertension, neurasthenia, pulmonary tuberculosis.

Radix Glehniae: cold nature, sweet in the mouth, micro-hardship.Return lung stomach warp.Nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid.Thirsty for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.Radix Glehniae contains volatile oil, coumarin, starch, alkaloid, triterpenic acid, stigmasterol, each sterol, and Radix Adenophorae (Radix Glehniae) element waits composition.Experiment proves, Radix Glehniae can improve T cell ratio, improves lymhocyte transformation rate, leukocyte increasing, strengthens macrophage function, extends antibody life period, improves B cell, Promote immunity function.Radix Glehniae can strengthen healthy energy, reduces disease, the generation of prophylaxis of cancer.

Fructus Lycii: Fructus Lycii: sweet, flat.Folium Lycii: bitter, sweet; Cool in nature.Enter liver, kidney, lung meridian.Control hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand." Treatise on Dietetic Therapy ": " hard muscle is always resistance to, and except wind, tonification muscles and bones, the beneficial people of energy, removes asthenia." effect such as lycium barbarum polysaccharide has Promote immunity, defying age, antitumor, scavenging free radicals, resisting fatigue, radioprotective, protects the liver, reproductive function protection and improvement.Carotene is the main active of wolfberry pigment, has antioxidation and as the important physiological function of the synthesis precursor etc. of vitamin A.Mouse gavaging Fructus Lycii water extract or intramuscular injection alcohol extract and lycium barbarum polysaccharide, the phagocytic function of the macrophage that is improved, strengthens the effect of serum lysozyme, improves tiring of anti-sheep red blood cell (SRBC) antibody in serum.Wolfberry fruit extract significantly and lastingly can reduce rat blood sugar, increase carbohydrate tolerance, and toxicity is less.

Fructus Corni: (Fructus Corni) is sour, puckery, tepor; Enter liver, the heart, kidney three warp.Invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse." Mingyi Bielu " carries: " Fructus Corni tepor, nontoxic.Cure mainly the intestines and stomach ailment said due to cold or exposure, cold and heat hernia abdominal mass ... deafness, the therapeutic method to keep the adverse QI flowing downwards, perspires, benefit essence, settling five organs, logical nine orifices, only normal urination." Materia Medica of Decoction: " and sliding then QI prostration, astringent is so receive it, and Fructus Corni stops normal urination, secret vital essence get its sour-puckery flavor with receive sliding also." invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.Fructus Corni spray 2 ~ 8g/kg, to cat intravenous drip, can strengthen its myocardial contractility, improves cardiac efficiency, and expansion peripheral blood vessel, obviously strengthens cardiac pumping function, blood pressure is raised.All gate of vitality's heateds, strong sun not flaccidity, have damp and hot, and the puckery person of urine leaching avoids clothes.Collective Notes to the Canon of Materia medica: " Fructus polygoni hydropiperis makes for it.Dislike Radix Platycodonis, Radix Saposhnikoviae, Radix Stephaniae Tetrandrae.”

Semen Ziziphi Spinosae: sweet, sour, property is put down.GUIXIN warp, spleen channel, Liver Channel, gallbladder meridian.Nourishing the liver, mind calming, calms the nerves, arresting sweating.There are calmness, hypnosis, analgesia, anticonvulsant action; There is certain hypotensive effect; Excitation is had to uterus.For deficiency of YIN-blood, severe palpitation, insomnia forgetfulness; The empty hyperhidrosis of body.Shennong's Herbal: " invigorating middle warmer the liver benefiting, hard muscles and bones help cloudy gas, and all the merit of Semen Ziziphi Spinosae also." " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." " not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong." " property of medicine opinion ": " main muscles and bones wind is fried end and is taken it as soup.Function " nourishing the liver, mind calming, calms the nerves, arresting sweating.There are calmness, hypnosis, analgesia, anticonvulsant action; There is certain hypotensive effect; Excitation is had to uterus.For deficiency of YIN-blood, severe palpitation, insomnia forgetfulness; The empty hyperhidrosis of body.To rat, oral or lumbar injection all behaves with composure and somnolence Semen Ziziphi Spinosae decoct, no matter daytime or night, and Semen Ziziphi Spinosae all can show above-mentioned effect.All have excess pathogen stagnated fire and suffer from the careful clothes of lingering diarrhea disease person.

Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, return spleen, stomach, Liver Channel, for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, modern study Fructus Crataegi, containing materials such as saccharide, protein, fat, vitamin C, carotene, starch, malic acid, citric acid, calcium and ferrum, has the effects such as blood fat reducing, blood pressure, heart tonifying and arrhythmia.Flavone compound vitexin in Fructus Crataegi, be the medicine that a kind of antitumaous effect is stronger, Fructus Crataegi extract all has certain inhibitory action to cancerous cell tumor growth, propagation and infiltration metastasis.It is stagnant that Fructus Crataegi can enter taste removing food stagnancy, loose stagnated blood, therefore in harness the river dysentery and puerpera's abdomen block pain is also.On the whole its merit be longer than dissipating fluid-retention food, strengthening the spleen and stomach, row stagnation of QI, repercussive blood, thus children's puerpera should polyphagia it.Can prevention and cure of cardiovascular disease, there is blood vessel dilating, increase coronary flow, improve heart vigor, stimulating central nervous system system, reduce blood pressure and cholesterol, vessel softening and diuresis and sedation; There is cardiotonic, senile heart disease is benefited; Energy appetite-stimulating indigestion-relieving, offsets meat stagnation effect better; There is effect of activating blood circulation to dissipate blood stasis, contribute to removing local congestion state, have auxiliary curative effect to traumatic injury; Have contraction to uterus, anemia of pregnant woman just before giving birth time have the effect expedited the emergence of, and uterine involution in puerperal can be promoted; Contained flavonoid and the substance such as vitamin C, carotene block, and reduce the generation of free radical, the immunity of enhancing body, has anti-aging, anticancer effect; Having in Fructus Crataegi relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.

Spica Prunellae: bitter in the mouth, pungent, cold in nature, enters liver, gallbladder meridian, has and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence." herbal classic ": " main cold and heat, scrofula, scrofula, head sore, broken disease, loose wart stagnation of QI, swelling of the feet arthralgia chiefly caused by damp pathogen." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " liver-wind of dispelling, network of passing through, controls facial hemiparalysis.Row irritability, opens stagnation of liver-QI, only bones and muscles pain, ophthal malgia, and loose scrofula is stolen, whole body tuberculosis." have and relieve inflammation or internal heat, improving eyesight, eliminating stagnation, effect of detumescence, cures mainly conjunctival congestion and swelling pain, and order pearl nyctalgia, has a headache dizzy, scrofula, and goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, the cards such as hypertension, hyperglycemia, hyperlipidemia and high blood viscosity, Spica Prunellae all has inhibitory action to dysentery bacterium, escherichia coli, cholera bacilli etc.The function of Spica Prunellae is liver heat removing and eyesight improving, uses stagnation resolvation tumor, also has the effect of diuretic antihypertensive.Among the peoplely to make tea with it again, do refrigerant passive summer-heat agent.

The Rhizoma Pinelliae: its acrid in the mouth, warm in nature, poisonous; Return spleen, stomach, lung meridian.Function drying dampness to eliminate phlegm, and middle stomach invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, external can reducing swelling and alleviating pain.Can be used for expectorant damp-phlegm rare and many clearly, cold-phlegm, often join Pericarpium Citri Reticulatae.Due to Rhizoma Pinelliae strong toxicity, after concocting, toxicity can weaken, suitable for oral administration.It has antitussive effect: Rhizoma Pinelliae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Rhizoma Zingiberis Recens soak the decoct of the Rhizoma Pinelliae and the Alumen Rhizoma Pinelliae, 0.6-1g/kgig or iv has obvious antitussive effect to the cough that cat iodine liquid injects caused by thoracic cavity or electricity irritation superior laryngeal nerve, and can maintain more than 5 hours.The antitussive effect of 0.6g/kg is close to the effect of codeine lmg/kg.Medication is avoided: all blood disorders and deficiency of YIN cough caused by dryness, Tianjin are hindered thirster and avoided clothes.Collective Notes to the Canon of Materia medica records it: " Rhizoma Belamcandae makes for it.Dislike Fructus Gleditsia.Fear Realgar, Rhizoma Zingiberis Recens, Rhizoma Zingiberis, Cortex Fraxini, Carapax Et Plastrum Testudinis.Anti-Aconitum carmichjaelii Debx. ".

Pericarpium Citri Reticulatae: nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Therefore Pericarpium Citri Reticulatae has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three large on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can support spleen, pungently can be amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and the gas of middle Jiao passes through, and the gas of three Jiao is also sprung up thereupon.Three Jiao are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, upper and the heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, wet throughout whole body.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold, can control abundant expectoration cough with asthma, and gas is stopped up food and stopped; Say from the heart, then pungent happy gas, hardship lets out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; Say from liver, then pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver be strongly fragrant heat, drink is stopped eating stagnant; Say from kidney, then pungent profit kidney is dry, and hardship is let out kidney and wet, gentle kidney qi, so it can control life fire deficiency, and indigestion.Certainly, all explanations are all relevant with spleen with wet, so its property of medicine effect performance leeway is larger, all can use in general activating QI to eliminate phlegm side.Have hypotensive effect slowly to anesthetized rabbit, cat, dog intravenous injection, its decompression principle is owing to directly acting on vascular smooth muscle.1. to cardiovascular effect a small amount of Pericarpium Citri Reticulatae decoct, toad heart contractility in vitro and in place is strengthened, output increases, little to Heart rate influences, then there is Cardiac depression in escalated dose, extrasomatic rabbit heart perfusion can make coronary vasodilation, Bufo siccus systemic perfusion makes flow reduce, the intravenous injection of Pericarpium Citri Reticulatae decoct can make dog kidney volume reduce, Renal vascular shrinks, hypourocrinia, can make arterial pressure rise to dog and rabbit, has the decline phenomenon of short time after blood pressure recovers, its effect is very similar to epinephrine, and medication does not also produce toleration repeatedly.Containing hesperidin in Pericarpium Citri Reticulatae, Syneilesis Maxim amount can be made to increase, can the vasoconstriction that causes of antagonism epinephrine.The methylhesperidin of synthetic, for the methylhesperidin mixture of multiple flavanone type and chalcone type, the effect reducing vascular permeability is strong compared with other flavonoid glycoside, dilating effect is had to Canis familiaris L. coronary vasodilator, on heart-lung apparatus and extrasomatic rabbit heart perfusion experiment, do not affect contractile force and heart rate, but because blood pressure drops can cause reflexive heart rate to accelerate during integral experiment, the coronary vasodilation of methylhesperidin to extrasomatic rabbit heart of 0.5 ~ 1 milligram act as 1/2 ~ 1/4 of theophylline effect, but the persistent period is more of a specified duration, dosage increases to 10 milligram hours, the dilating effect of coronary vasodilator is strengthened, on contractile force and heart rate still without impact.Have hypotensive effect slowly to anesthetized rabbit, cat, dog intravenous injection, its decompression principle is owing to directly acting on vascular smooth muscle.Each monomer in research methylhesperidin mixture, to the hypotensive effect of rabbit, the effect of extrasomatic rabbit heart coronary vasodilation, animal rear amine perfusion (Femoral Artery Injection) in place increases the effect of flow, the strongest with the 3'-methyl-7-rhamnose-2-methyl glucoside-hesperetin effect of flavanone type.In reasonable controlled atmosphere, drying dampness to eliminate phlegm effect, can be used for treating stagnation of QI in spleen and stomach, distension and fullness in the abdomen, vomiting, or uncomfortable in chest caused by turbid damp obstructing in middle-JIAO, indigestion and loss of appetite, loose stool, but YIN fluid deficiency, person is cautious use of inside to have excess-heat.

Pericarpium Trichosanthis: nature and flavor sweetness and bitterness, cold.Enter lung, stomach, large intestine channel.Function cures mainly: lung moistening, reduces phlegm, eliminating stagnation, intestine moistening.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of." detailed outline " is said: " lung moistening is dry, pathogenic fire reducing.Control cough, clearing away phlegm is tied, throat, subduing inflammation sore." " book on Chinese herbal medicine is just read " record: " and Fructus Trichosanthis, nature and flavor are identical with pollen, only the profit merits and demerits of falling it.Therefore all stagnation of heat in upper-JIAOs, the cards such as dirty greasy phlegm-fire cough, all can use it.The fiery person of genus of all lung abscess, acute appendicitis, acute mastitis, particularly suitable.”

Rhizoma Corydalis: pungent, bitter, temperature.GUIXIN, liver, spleen channel.Invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, pain relieving.The all pains of main trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.1, analgesic activity: Rhizoma Corydalis powder has analgesic activity, its pain relieving is tired and is about 1/100 of opium; Rhizoma Corydalis total alkaloids, Corydaline, B prime, Chou prime, Kui prime all have analgesic activity, stronger with B prime. various dosage form with alcohol extractum and powder effect strong.2, calm, stable, syngignoscism: tetrahydropalmatine has certain calmness, stable effect, and its levo form is novel central inhibitor, has obvious syngignoscism during larger dose to rabbit, Canis familiaris L., monkey.3, on the impact of digestive system: dehydrogenation Corydaline has significant anti-Experimental Gastric Ulcer in Rats effect.4, to cardiovascular effect: tetrahydropalmatine, Chou prime have slight blood pressure lowering, decreased heart rate effect; Dehydrocory daline has blood pressure lowering, increases CBSF effect. the rat heart muscle necrosis effect that ethanol extract also has coronary artery dilating, antagonism isoproterenol causes.

Caulis Entadae: nature and flavor are " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: " the large temperature of property, acrid in the mouth." 2. " Yunnan Chinese herbal medicine ": " is pungent, tepor." [function cures mainly] dredges wind prevailing over dampness, relaxing muscles and tendons and activating QI and blood in the collateral, diuresis, dissipating blood stasis.Control arthralgia chiefly caused by damp pathogen apathy, bones and muscles pain, gonorrhea, traumatic injury.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " row whole body meridians, dispersing wind-cold dampness.Control brothers' arthralgia chiefly caused by damp pathogen, meciless numbness, the dampness tuberculosis of bone and joint, bones and muscles pain, or muscles and bones of injuring, accidentally injure meridians.The strong muscle relaxing muscles and tendons of energy, active analgesic therapy." 2. " Guizhou side's medicine among the people collection ": " controls pulmonary cough." 3. " Traditional Chinese Medicine in Sichuan will ": " controls menoxenia and tetany." 4. " Hunan medicine will ": " diuresis, relaxing muscles and tendons."

Herba Erigerontis: [nature and flavor] are " Yunnan Chinese herbal medicine " 1.: " sweet, temperature." 2. " choosing of Yunnan Chinese herbal medicine ": " is pungent, tepor." [function cures mainly] expelling cold and relieving exterior syndrome, relaxing muscles and tendons to promote blood circulation, pain relieving, removing food stagnancy.Cure cold headache nasal obstruction, rheumatic arthralgia, paralysis, acute gastritis, infantile malnutrition, traumatic injury.1. " register planted by Guangxi medicine ": " control children's's head sore." 2. " Yunnan Chinese herbal medicine ": " delivers cold expelling, spleen invigorating removing food stagnancy, anti-inflammatory analgetic." 3. " choosing of Yunnan Chinese herbal medicine ": " expelling cold and relieving exterior syndrome, pain relieving, relaxing muscles and tendons to promote blood circulation.Control toothache, acute gastritis, high heat, traumatic injury, rheumatalgia, chest pain, malaria, poliomyelitis sequela, the paralysis of encephalitis sequela, schistosomicide."

Nidus Vespae: [nature and flavor] are sweet is flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be salty." 3. " detailed outline ": " is sweet, flat." [returning through] 1. " detailed outline ": " enters Yangming Channel." 2. " book on Chinese herbal medicine is new again ": " enters liver, lung two warp." [function cures mainly] dispels the wind, counteracting toxic substances, parasite killing.Control infantile convulsion, migratory arthralgia, urticaria pruritus, acute mastitis, furunculosis, scrofula, anal fistula, acute toothache, tinea capitis, honeybee stings swollen pain.1. " herbal classic ": " main infantile convulsion Chi Zong, cold and heat pathogen, insane disease, perianal abscess." 2. " not Lu ": " treats Venenum apis, and poison is swollen." 3. Tang Materia Medica: " ash, wine takes, main impotence; Decocting in water washes contact dermatitis skin ulcer; Gas in the treatment of clothes, dysentery with red and white feces, tooth pain is controlled in enuresis incontinence, " 4. " Japan hanako materia medica ": ", dysentery, acute mastitis; Honeybee stings, malignant boil, namely decocts and washes." 5. " book on Chinese herbal medicine converges and says ": " wind dispelling counteracting toxic substances, loose furuncle swells vicious." 6. " book on Chinese herbal medicine is stated ": " controls long-pending expectorant chronic cough, and wind is shivered with terror and, coma entanglement."

Herba speranskiae tuberculatae: nature and flavor are " book on Chinese herbal medicine is original " 1.: " sweet in the mouth is nontoxic." 2. " Chinese medicinal herbal ": " is pungent, temperature." [function cures mainly] dispels the wind, and dehumidifying, relaxing muscles and tendons, invigorates blood circulation, pain relieving.Dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness, skin ulcer tinea toxic swelling.1. " detailed outline ": " control all rheumatalgia contractures of muscles and bones, the disturbance of lower legs due to pathogenic cold and dampness." 2. " the secret red medicine writing paper of spirit ": " treats pyretic toxicity." 3. " Shandong Chinese herbal medicine handbook ": " wind-damp dispelling, invigorates blood circulation, pain relieving."

Herba hemipharagmatis heterophylli: [nature and flavor] are light is flat.[function cures mainly] promoting blood flow to regulate menstruation, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness.For amenorrhea, menoxenia, pulmonary tuberculosis, tonsillitis, traumatic injury, lumbago due to pathogenic wind-dampness; Eczema is controlled in external, skin infection, stomatitis.

Red large-leaved dogwood: [habitats distribution] ecological environment: in the small stream limit being born in height above sea level 1350-3700m or shaw.Resource distribution: be distributed in the ground such as Shanxi, Shaanxi, Gansu, Qinghai, Henan, Hubei, Sichuan, Guizhou, Yunnan and Tibet.[nature and flavor] acrid in the mouth; Property is put down.[function cures mainly] wind-expelling pain-stopping; Relaxing muscles and tendons and activating QI and blood in the collateral.Main air pain of dampness syndrome; Impairment caused by overstrain lumbago and skelalgia; Quadriplegia.

Thunderclap pasture and water: [nature and flavor] " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " sweet-bitter flavor, cold in nature." [function cures mainly] tonify deficiency, dehumidifying, relaxing muscles and tendons and activating QI and blood in the collateral.Control deficiency-heat not move back, oedema due to nephritis, rheumatic arthralgia, eczema.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control all deficiency syndrome, sexual impotence loss of fecundity, adopts and take it." 2. " high bright conventional medical herbs among the people ": " diaphoresis dehumidifying, clear heat in the interior." 3. " choosing of Simao, Yunnan Chinese herbal medicine ": " relaxing muscles and tendons and activating QI and blood in the collateral, wind-damp dispelling, diuresis, treating rheumatic arthritis, waist knee joint arthralgia chiefly caused by damp pathogen, oedema due to nephritis."

Cortex Premnae szemaoensis Radicis: [habitats distribution] is born in roadside, limes marginis area without shade or hillside shaw.Distribution Yunnan.[nature and flavor] are " Yunnan Chinese herbal medicine " 1.: " sweet micro-hardship, flat." 2. " choosing of Yunnan Chinese herbal medicine ": " is puckery, cold." [function cures mainly] be " Yunnan Chinese herbal medicine " 1.: " synthetism, hemostasis.Control fracture." 2. " choosing of Simao, Yunnan Chinese herbal medicine ": " relaxing muscles and tendons to promote blood circulation, synthetism is eased pain, hemostasia and promoting granulation.Control fracture, traumatic pain, traumatic hemorrhage, rheumatic ostalgia."

Radix et Rhizoma Gynurae divaricatae: nature and flavor acrid in the mouth; Light; Property is put down.[function cures mainly] clearing away heat and cooling blood; Promoting blood circulation and stopping pain; Hemostasis.Main cough; Skin infection; Scald scorching wound; Traumatic injury; Rheumatalgia; Metrorrhagia; Traumatic hemorrhage.

Lotus throne lead fungi: [nature and flavor] are sweet; Flat.[function cures mainly] expelling wind and cold; Relaxing muscles and tendons and activating QI and blood in the collateral.Main air pain of dampness syndrome; The contracture of muscle arteries and veins.

Carnis Equi Asini: [nature and flavor] sweet acid is flat.[function cures mainly] enriches blood, QI invigorating.Control strain, dizziness due to wind pathogen, vexed.1. " a thousand pieces of gold dietetic therapy ": " main air is mad, and anxious melancholy is discomfort, gas of feeling at ease." 2. " Japan hanako materia medica ": " relaxing vexation, only wind is mad, and a wind cutting is controlled in wine brewing." 3. principle of Correct Diet: " wild donkey, food can control dizziness due to wind pathogen." 4. " detailed outline ": " blood yiqi, controls many years ago strain; The hollow bank of liquor, treats hemorrhoid and draws worm."

Radix grewiae bilobae: [nature and flavor] are sweet; Bitter; Temperature.[return through] liver; Spleen; Stomach warp.[function cures mainly] invigorating the spleen and benefiting QI; Expelling wind and removing dampness; Treating spontaneous emission and leukorrhagia.Main insufficiency of the spleen lack of appetite; Proctoptosis of a specified duration; Infantile malnutrition; Ascariasis; Rheumatic arthralgia; Seminal emission; Metrorrhagia; Leukorrhagia; Uterine prolapse.

Amylum Trapae: the sarcocarp that [source] is Trapaceae plant Pedicellus et Pericarpium Trapae or its congener, smashes the starch of juice levigation.[chemical analysis] is containing amylose 15%.[function cures mainly] 1. Zhu Quan: " invigorating middle warmer." 2. " detailed outline is picked up any lost article from the road ": " tonifying the spleen and stomach, strong foot knee joint, strong power QI invigorating, row water, drives away summer heat, removing toxic substances."

Testis et Pentis Canis: [nature and flavor] sweet in the mouth; Salty; Warm in nature.[return through] kidney channel.[function cures mainly] the kidney invigorating warming YANG.Main coldness of the body of suffering from a deficiency of the kidney.

Bamboo grove clouds: [nature and flavor] sweet in the mouth; Light; Property is put down.[function cures mainly] nourishing the lung to arrest cough; Strong gland helps digestion; Relaxing muscles and tendons and activating QI and blood in the collateral; Heat-clearing and toxic substances removing.Main cough due to lung-heat; Pulmonary tuberculosis is spat blood; Food stagnation distension; Rheumatic arthralgia; Lumbago and skelalgia; Fracture; Burn.

Herba Syneilesis Aconitifoliae: [nature and flavor] toil, temperature.1. herbal for Relief of Famines: " bitter in the mouth is micro-pungent." 2. " Guizhou folk medicine ": " slightly warm in nature, acrid in the mouth is nontoxic." 3. " Shaanxi Chinese herbal medicine ": " is slightly poisonous." [function cures mainly] expelling wind and removing dampness, removing toxic substances is invigorated blood circulation, reducing swelling and alleviating pain.Dispelling the wind and dampness pathogens is numb, arthralgia, and carbuncle skin ulcer swells, traumatic injury.1. " Nanjing medicinal herbs among the people ": " root: decoct water and take orally or external application affected part, control traumatic injury." 2. " Guizhou folk medicine ": " relaxing muscles and tendons to promote blood circulation." 3. " Shaanxi Chinese herbal medicine "; " expelling wind and removing dampness, reducing swelling and alleviating pain.Dispelling the wind and dampness pathogens is numb, rheumatic arthritis, lumbago and skelalgia, fracture, menoxenia, dysmenorrhea." 4. " Zhejiang conventional medical herbs among the people ": " subduing swelling and detoxicating.Control cervical lymphadenitis, venom."

Cortex alni nepalensis: nature and flavor " choosing of Simao, Yunnan Chinese herbal medicine ": " pained, cool." [function cures mainly] be " Guizhou medical herbs " 1.: " diuretic.Harness the river swollen." 2. " choosing of Simao, Yunnan Chinese herbal medicine ": " heat-clearing and toxic substances removing, relaxing muscles and tendons network, wind-damp dispelling.Control bacillary dysentery, diarrhoea, rheumatic ostalgia, injury and bone fracture."

Ground is your grass: nature and flavor are pungent; Temperature.[function cures mainly] relaxing muscles and tendons and activating QI and blood in the collateral; Expelling wind and removing dampness.Main bones and muscles pain due to rheumatism; Impairment caused by overstrain pain.

Preferably, described spray is only made up of above-mentioned raw materials medical material.

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.

Embodiment 1 spray 1

Embodiments provide one and treat angiospastic spray, formula is: 23 parts, the Radix Rehmanniae, Radix Glehniae 12 parts, Fructus Lycii 10 parts, Fructus Corni 11 parts, Semen Ziziphi Spinosae 15 parts, Fructus Crataegi 10 parts, Spica Prunellae 8 parts, the Rhizoma Pinelliae 5 parts, Pericarpium Citri Reticulatae 11 parts, Pericarpium Trichosanthis 25 parts, Rhizoma Corydalis 10 parts, Caulis Entadae 18 parts, Herba Erigerontis 12 parts, Nidus Vespae 3 parts, Herba speranskiae tuberculatae 12 parts, Herba hemipharagmatis heterophylli 14 parts, red large-leaved dogwood 16 parts, 17 parts, thunderclap pasture and water, Cortex Premnae szemaoensis Radicis 22 parts, Radix et Rhizoma Gynurae divaricatae 18 parts, lotus throne lead fungi 7 parts, Carnis Equi Asini 8 parts, Radix grewiae bilobae 17 parts, Amylum Trapae 12 parts, Testis et Pentis Canis 5 parts.

Its preparation method is:

The first step: the raw medicinal material Radix Rehmanniae, Radix Glehniae, Fructus Lycii, Fructus Corni are passed through according to proportioning and is ground into 200 object powder;

Second step: be mixed in proportion by remaining each raw medicinal material weight portion, stirs and pulverizes, add 4 times of water relative to crude drug quality sum, decoct 2 hours, decoction liquor is filtered, and filtering residue adds relative to crude drug quality sum 3 times of water again, again decoct 1.5 hours, decoction liquor is filtered, and is merged by filtrate, adds the active carbon of 0.1 times amount, boil 50 minutes, after natural cooling, through centrifugal, sucking filtration, obtain filtrate;

3rd step: the filtrate mixing that the powder first step obtained and second step obtain, and through purification twice, obtain purification liquid, heating is concentrated into the medicinal liquid that concentration is 3g/ml;

4th step: get described medicinal liquid 15ml, adds 0.1ml tween 80,90mg sodium sulfite wherein successively, injects water to 100ml after mix homogeneously, and with sodium hydroxide adjust pH to 6.8, finally be sub-packed in cillin bottle, after boiling water bath heat sterilization, obtain spray.

Embodiment 2 injection

Embodiments provide one and treat angiospastic injection, formula is: 23 parts, the Radix Rehmanniae, Radix Glehniae 12 parts, Fructus Lycii 10 parts, Fructus Corni 11 parts, Semen Ziziphi Spinosae 15 parts, Fructus Crataegi 10 parts, Spica Prunellae 8 parts, the Rhizoma Pinelliae 5 parts, Pericarpium Citri Reticulatae 11 parts, Pericarpium Trichosanthis 25 parts, Rhizoma Corydalis 10 parts, Caulis Entadae 18 parts, Herba Erigerontis 12 parts, Nidus Vespae 3 parts, Herba speranskiae tuberculatae 12 parts, Herba hemipharagmatis heterophylli 14 parts, red large-leaved dogwood 16 parts, 17 parts, thunderclap pasture and water, Cortex Premnae szemaoensis Radicis 22 parts, Radix et Rhizoma Gynurae divaricatae 18 parts, lotus throne lead fungi 7 parts, Carnis Equi Asini 8 parts, Radix grewiae bilobae 17 parts, Amylum Trapae 12 parts, Testis et Pentis Canis 5 parts.

Its preparation method is:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 36 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 minutes at this, the micron particles of acquisition 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, gets the mixed powder 20g that second step obtains, adds propylene glycol 30g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g needle-use activated carbon, fully stirs 30 minutes; Decarbonization filtering; With 0.22 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.

Embodiment 3 spray 2

Embodiments provide one and treat angiospastic spray, formula is: 25 parts, the Radix Rehmanniae, Radix Glehniae 12 parts, Fructus Lycii 9 parts, Fructus Corni 11 parts, Semen Ziziphi Spinosae 14 parts, Fructus Crataegi 10 parts, Spica Prunellae 7 parts, the Rhizoma Pinelliae 7 parts, Pericarpium Citri Reticulatae 12 parts, Pericarpium Trichosanthis 22 parts, Rhizoma Corydalis 9 parts, Caulis Entadae 17 parts, Herba Erigerontis 12 parts, Nidus Vespae 4 parts, Herba speranskiae tuberculatae 13 parts, Herba hemipharagmatis heterophylli 14 parts, red large-leaved dogwood 15 parts, 18 parts, thunderclap pasture and water, Cortex Premnae szemaoensis Radicis 22 parts, Radix et Rhizoma Gynurae divaricatae 17 parts, lotus throne lead fungi 7 parts, Carnis Equi Asini 8 parts, Radix grewiae bilobae 16 parts, Amylum Trapae 12 parts, Testis et Pentis Canis 5 parts, bamboo grove clouds 13 parts, Herba Syneilesis Aconitifoliae 17 parts, Cortex alni nepalensis 9 parts, expensive careless 9 parts of ground.

Its preparation method is:

The first step: the raw medicinal material Radix Rehmanniae, Radix Glehniae, Fructus Lycii, Fructus Corni are passed through according to proportioning and is ground into 200 object powder;

Second step: be mixed in proportion by remaining each raw medicinal material weight portion, stirs and pulverizes, add 2 times of water relative to crude drug quality sum, decoct 2 hours, decoction liquor is filtered, and filtering residue adds relative to crude drug quality sum 1 times of water again, again decoct 1.5 hours, decoction liquor is filtered, and is merged by filtrate, adds the active carbon of 0.1 times amount, boil 50 minutes, after natural cooling, through centrifugal, sucking filtration, obtain filtrate;

3rd step: the filtrate mixing that the powder first step obtained and second step obtain, and through purification twice, obtain purification liquid, heating is concentrated into the medicinal liquid that concentration is 5g/ml;

4th step: get described medicinal liquid 15ml, adds 0.4ml tween 80,90mg sodium sulfite wherein successively, injects water to 100ml after mix homogeneously, and with sodium hydroxide adjust pH to 6.8, finally be sub-packed in cillin bottle, after boiling water bath heat sterilization, obtain spray.

Toxicity test

1. acute dermal toxicity test: test method(s) of once limiting the quantity, SD rat 20, male and female half and half, body weight 90g ~ 180g, the spray that the embodiment of the present invention 1 is obtained 1, percutaneous spray 5000mg/kg body weight dose, observe 15 days, do not find obvious poisoning symptom, without dead, animal gross anatomy no abnormality seen, judges that this medicine is to the nontoxic level in the true border of rat acute percutaneous toxicity.

2. acute skin test: male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg; get the spray 2 of the present embodiment 3; be sprayed on the left of animal on skin (opposite side in contrast), adopts blocking test, the 4 hours time; remain tested material with warm water washing after off-test; after removing tested material, 1h, 24h, 48h and 72h observe the dermoreaction of the tested district of animal and check plot respectively, and top average is " 0 ", judge that this medicine is to animal skin nonirritant.

3. hypersensitive test: get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The spray 2 getting the embodiment of the present invention 3 is sprayed on unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, at back, the same area smeared this product 0.1g, at once observes after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.Illustrate that medicine of the present invention does not have sensitization.

4. cumulative toxicity test: test method: select 20 healthy mices, female, each 10 of hero, with the injection of the embodiment of the present invention 2 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.Illustrate that this medicine does not have cumulative toxicity.

Clinical trial

Select 200 routine vasospasm patients.

Diagnostic criteria

1, blood pressure inspection.

2, neurologic check.

3, cerebral CT inspection.

Criterion of therapeutical effect

Concrete curative effect divides following three grades: cure---and-vasospasm pain all disappears; Effective----vasospasm pain obviously alleviates; Invalid----vasospasm pain has no to disappear.

Therapeutic Method

Spray 1 group: this is organized 50 people and uses the spray 1 of embodiments of the invention 1 to treat.Every day 2 times, being sprayed on vasospasm position, 2 days is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.After treating 2 courses for the treatment of, have 40 routine patients to start effectively, continual cure is consolidated 1 course for the treatment of, and have 49 routine patients to be cured, 1 routine patient is effectively alleviated.Cure rate is 98%, and effective percentage is 2%, and inefficiency is 0%.Moreover, over the course for the treatment of, there is side effect without any patient.Later stage follows up 3 months, does not recur.

Injection group: this is organized 50 people and uses the injection of embodiments of the invention 2 to treat.Every day 1 time, each use 50ml intravenous injection, within 2 days, be a course for the treatment of, 3 courses for the treatment of are carried out in treatment.After treating 2 courses for the treatment of, have 43 routine patients to start effectively, continual cure is consolidated 1 course for the treatment of, and have 50 routine patients to be cured, 1 routine patient is effectively alleviated.Cure rate is 100%, and effective percentage is 0%, and inefficiency is 0%.Moreover, over the course for the treatment of, there is side effect without any patient.Later stage follows up 3 months, does not recur.

Spray 2 groups: this is organized 50 people and uses the spray 2 of embodiments of the invention 3 to treat.Every day 2 times, being sprayed on vasospasm position, 2 days is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.After treating 1 course for the treatment of, have 26 routine patients to start effectively, continual cure is consolidated 2 courses for the treatment of, and have 50 routine patients to be cured, 1 routine patient is effectively alleviated.Cure rate is 100%, and effective percentage is 0%, and inefficiency is 0%.Moreover, over the course for the treatment of, there is side effect without any patient.Later stage follows up 3 months, does not recur.

Matched group: this is organized 50 people's thiophene chloropyridines and treats.Each 200--250mg, every day 1-2 time, in treatment, all should be noted the control strengthened the toxic and side effects such as hemorrhage.Within 2 days, be a course for the treatment of, 3 courses for the treatment of are carried out in treatment.Have 20 routine patients to be cured after treating 3 courses for the treatment of, 15 routine patients are effective, and 15 routine patients are invalid.Cure rate is 40%, and effective percentage is 30%, and inefficiency is 30%.There are 8 routine patients to occur hemorrhage complication over the course for the treatment of, have 6 routine patients to occur side effect and untoward reaction.Later stage follows up 3 months, has 3 people's recurrences in the patient of healing.

In sum, medicine of the present invention, treatment vasospasm, good effect, treatment is fast, determined curative effect, and has no side effect, safe and effective, not easily recurs.

Model case: Wang, women, 40 years old.There is vasospasm through brain Post operation, use the spray 2 of embodiments of the invention 3 to treat.Every day 2 times, being sprayed on vasospasm position, 2 days is a course for the treatment of, and 3 courses for the treatment of are carried out in treatment.1 course for the treatment of just cures, and consolidates, and over the course for the treatment of, do not occur any side effect through 2 courses for the treatment of.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (7)

1. the angiospastic spray for the treatment of, it is characterized in that, described spray is obtained by following raw medicinal material: the Radix Rehmanniae, Radix Glehniae, Fructus Lycii, Fructus Corni, Semen Ziziphi Spinosae, Fructus Crataegi, Spica Prunellae, the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Pericarpium Trichosanthis, Rhizoma Corydalis, Caulis Entadae, Herba Erigerontis, Nidus Vespae, Herba speranskiae tuberculatae, Herba hemipharagmatis heterophylli, red large-leaved dogwood, thunderclap pasture and water, Cortex Premnae szemaoensis Radicis, Radix et Rhizoma Gynurae divaricatae, lotus throne lead fungi, Carnis Equi Asini, Radix grewiae bilobae, Amylum Trapae and Testis et Pentis Canis.

2. spray according to claim 1, it is characterized in that, described spray is obtained by the raw medicinal material of following weight portion: Radix Rehmanniae 20-25 weight portion, Radix Glehniae 10-13 weight portion, Fructus Lycii 8-12 weight portion, Fructus Corni 10-12 weight portion, Semen Ziziphi Spinosae 10-20 weight portion, Fructus Crataegi 9-13 weight portion, Spica Prunellae 6-11 weight portion, Rhizoma Pinelliae 4-9 weight portion, Pericarpium Citri Reticulatae 10-13 weight portion, Pericarpium Trichosanthis 20-30 weight portion, Rhizoma Corydalis 9-12 weight portion, Caulis Entadae 15-25 weight portion, Herba Erigerontis 10-14 weight portion, Nidus Vespae 2-5 weight portion, Herba speranskiae tuberculatae 10-15 weight portion, Herba hemipharagmatis heterophylli 10-20 weight portion, red large-leaved dogwood 10-20 weight portion, thunderclap pasture and water 15-20 weight portion, Cortex Premnae szemaoensis Radicis 20-25 weight portion, Radix et Rhizoma Gynurae divaricatae 15-24 weight portion, lotus throne lead fungi 5-9 weight portion, Carnis Equi Asini 6-11 weight portion, Radix grewiae bilobae 12-20 weight portion, Amylum Trapae 10-14 weight portion and Testis et Pentis Canis 4-7 weight portion.

3. spray according to claim 1, is characterized in that, also comprises bamboo grove clouds, Herba Syneilesis Aconitifoliae, Cortex alni nepalensis, ground is your grass, and described spray is obtained by the raw medicinal material of following weight portion: Radix Rehmanniae 20-25 weight portion, Radix Glehniae 10-13 weight portion, Fructus Lycii 8-12 weight portion, Fructus Corni 10-12 weight portion, Semen Ziziphi Spinosae 10-20 weight portion, Fructus Crataegi 9-13 weight portion, Spica Prunellae 6-11 weight portion, Rhizoma Pinelliae 4-9 weight portion, Pericarpium Citri Reticulatae 10-13 weight portion, Pericarpium Trichosanthis 20-30 weight portion, Rhizoma Corydalis 9-12 weight portion, Caulis Entadae 15-25 weight portion, Herba Erigerontis 10-14 weight portion, Nidus Vespae 2-5 weight portion, Herba speranskiae tuberculatae 10-15 weight portion, Herba hemipharagmatis heterophylli 10-20 weight portion, red large-leaved dogwood 10-20 weight portion, thunderclap pasture and water 15-20 weight portion, Cortex Premnae szemaoensis Radicis 20-25 weight portion, Radix et Rhizoma Gynurae divaricatae 15-24 weight portion, lotus throne lead fungi 5-9 weight portion, Carnis Equi Asini 6-11 weight portion, Radix grewiae bilobae 12-20 weight portion, Amylum Trapae 10-14 weight portion, Testis et Pentis Canis 4-7 weight portion, bamboo grove clouds 10-20 weight portion, Herba Syneilesis Aconitifoliae 13-20 weight portion, the expensive careless 7-12 weight portion of Cortex alni nepalensis 8-12 weight portion and ground.

4. spray according to claim 1 and 2, it is characterized in that, described spray is obtained by the raw medicinal material of following weight portion: the Radix Rehmanniae 23 weight portion, Radix Glehniae 12 weight portion, Fructus Lycii 10 weight portion, Fructus Corni 11 weight portion, Semen Ziziphi Spinosae 15 weight portion, Fructus Crataegi 10 weight portion, Spica Prunellae 8 weight portion, the Rhizoma Pinelliae 5 weight portion, Pericarpium Citri Reticulatae 11 weight portion, Pericarpium Trichosanthis 25 weight portion, Rhizoma Corydalis 10 weight portion, Caulis Entadae 18 weight portion, Herba Erigerontis 12 weight portion, Nidus Vespae 3 weight portion, Herba speranskiae tuberculatae 12 weight portion, Herba hemipharagmatis heterophylli 14 weight portion, red large-leaved dogwood 16 weight portion, thunderclap pasture and water 17 weight portion, Cortex Premnae szemaoensis Radicis 22 weight portion, Radix et Rhizoma Gynurae divaricatae 18 weight portion, lotus throne lead fungi 7 weight portion, Carnis Equi Asini 8 weight portion, Radix grewiae bilobae 17 weight portion, Amylum Trapae 12 weight portion and Testis et Pentis Canis 5 weight portion.

5. the spray according to claim 1 or 3, it is characterized in that, described spray is obtained by the raw medicinal material of following weight portion: the Radix Rehmanniae 25 weight portion, Radix Glehniae 12 weight portion, Fructus Lycii 9 weight portion, Fructus Corni 11 weight portion, Semen Ziziphi Spinosae 14 weight portion, Fructus Crataegi 10 weight portion, Spica Prunellae 7 weight portion, the Rhizoma Pinelliae 7 weight portion, Pericarpium Citri Reticulatae 12 weight portion, Pericarpium Trichosanthis 22 weight portion, Rhizoma Corydalis 9 weight portion, Caulis Entadae 17 weight portion, Herba Erigerontis 12 weight portion, Nidus Vespae 4 weight portion, Herba speranskiae tuberculatae 13 weight portion, Herba hemipharagmatis heterophylli 14 weight portion, red large-leaved dogwood 15 weight portion, thunderclap pasture and water 18 weight portion, Cortex Premnae szemaoensis Radicis 22 weight portion, Radix et Rhizoma Gynurae divaricatae 17 weight portion, lotus throne lead fungi 7 weight portion, Carnis Equi Asini 8 weight portion, Radix grewiae bilobae 16 weight portion, Amylum Trapae 12 weight portion, Testis et Pentis Canis 5 weight portion, bamboo grove clouds 13 weight portion, Herba Syneilesis Aconitifoliae 17 weight portion, expensive careless 9 weight portions of Cortex alni nepalensis 9 weight portion and ground.

6. the spray according to any one of claim 1 to 5, is characterized in that, its preparation method comprises the following steps:

The first step: the raw medicinal material Radix Rehmanniae, Radix Glehniae, Fructus Lycii, Fructus Corni are passed through according to proportioning and is ground into 200-250 object powder;

Second step: be mixed in proportion by remaining each raw medicinal material weight portion, stirs and pulverizes, add the 2-4 times of water relative to crude drug quality sum, decoct 1-2 hour, decoction liquor is filtered, and filtering residue adds relative to crude drug quality sum 1-3 times of water again, again decoct 1.5-2 hour, decoction liquor is filtered, and is merged by filtrate, adds the active carbon of 0.1-0.5 times amount, boil 50-80 minute, after natural cooling, through centrifugal, sucking filtration, obtain filtrate;

3rd step: the filtrate mixing that the powder first step obtained and second step obtain, and through purification twice, obtain purification liquid, heating is concentrated into the medicinal liquid that concentration is 1g/ml-5g/ml;

4th step: get described medicinal liquid 15ml, adds 0.1-0.4ml tween 80,30-90mg sodium sulfite wherein successively, injects water to 100ml after mix homogeneously, and with sodium hydroxide adjust pH to 6.6-6.8, finally be sub-packed in cillin bottle, after boiling water bath heat sterilization, obtain spray.

7. a preparation method for the spray according to any one of claim 1 to 5, is characterized in that, its preparation method comprises:

The first step: by the raw medicinal material Radix Rehmanniae, Radix Glehniae, Fructus Lycii, Fructus Corni through being ground into 200 object powder;

Second step: be mixed in proportion by remaining each raw medicinal material weight portion, stirs and pulverizes, add the 2-4 times of water relative to crude drug quality sum, decoct 1-2 hour, decoction liquor is filtered, and filtering residue adds relative to crude drug quality sum 1-3 times of water again, again decoct 1.5-2 hour, decoction liquor is filtered, and is merged by filtrate, adds the active carbon of 0.1-0.5 times amount, boil 50-80 minute, after natural cooling, through centrifugal, sucking filtration, obtain filtrate;

3rd step: the filtrate mixing that the powder first step obtained and second step obtain, and through purification twice, obtain purification liquid, heating is concentrated into the medicinal liquid that concentration is 1g/ml-5g/ml;

4th step: get described medicinal liquid 15ml, adds 0.1-0.4ml tween 80,30-90mg sodium sulfite wherein successively, injects water to 100ml after mix homogeneously, and with sodium hydroxide adjust pH to 6.6-6.8, finally be sub-packed in cillin bottle, after boiling water bath heat sterilization, obtain spray.