CN1579454A - A pharmaceutical composition for treating cerebral thrombosis and myocardial infarction - Google Patents
A pharmaceutical composition for treating cerebral thrombosis and myocardial infarction Download PDFInfo
- Publication number
- CN1579454A CN1579454A CN 03149985 CN03149985A CN1579454A CN 1579454 A CN1579454 A CN 1579454A CN 03149985 CN03149985 CN 03149985 CN 03149985 A CN03149985 A CN 03149985A CN 1579454 A CN1579454 A CN 1579454A
- Authority
- CN
- China
- Prior art keywords
- weight portion
- radix
- pharmaceutical composition
- blood
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 12
- 206010008132 Cerebral thrombosis Diseases 0.000 title claims abstract description 10
- 201000001429 Intracranial Thrombosis Diseases 0.000 title claims abstract description 10
- 208000010125 myocardial infarction Diseases 0.000 title claims abstract description 6
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 9
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims description 20
- 241000903946 Clematidis Species 0.000 claims description 10
- 241001243666 Photinia serratifolia Species 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 229940040145 liniment Drugs 0.000 claims description 3
- 239000000865 liniment Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 30
- 210000004369 blood Anatomy 0.000 abstract description 30
- 230000017531 blood circulation Effects 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 16
- 230000001737 promoting effect Effects 0.000 abstract description 12
- 206010008190 Cerebrovascular accident Diseases 0.000 abstract description 10
- 208000006011 Stroke Diseases 0.000 abstract description 10
- 206010003210 Arteriosclerosis Diseases 0.000 abstract description 6
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract description 6
- 230000003213 activating effect Effects 0.000 abstract description 4
- 230000017423 tissue regeneration Effects 0.000 abstract description 3
- 206010008088 Cerebral artery embolism Diseases 0.000 abstract description 2
- 206010008111 Cerebral haemorrhage Diseases 0.000 abstract description 2
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 abstract description 2
- 201000010849 intracranial embolism Diseases 0.000 abstract description 2
- 208000001286 intracranial vasospasm Diseases 0.000 abstract description 2
- 241000218158 Clematis Species 0.000 abstract 1
- 241000723369 Cocculus trilobus Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 241001116742 Drynaria Species 0.000 abstract 1
- 241001090156 Huperzia serrata Species 0.000 abstract 1
- 241000195954 Lycopodium clavatum Species 0.000 abstract 1
- 241001598357 Stephania delavayi Species 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 208000005189 Embolism Diseases 0.000 description 23
- 210000003414 extremity Anatomy 0.000 description 13
- 210000001367 artery Anatomy 0.000 description 12
- 208000001435 Thromboembolism Diseases 0.000 description 10
- 206010020772 Hypertension Diseases 0.000 description 9
- 208000026106 cerebrovascular disease Diseases 0.000 description 8
- 230000003387 muscular Effects 0.000 description 8
- 230000036772 blood pressure Effects 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 210000002216 heart Anatomy 0.000 description 7
- 208000007536 Thrombosis Diseases 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- 238000001467 acupuncture Methods 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- 206010028851 Necrosis Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- 230000017074 necrotic cell death Effects 0.000 description 4
- 206010019468 Hemiplegia Diseases 0.000 description 3
- 206010033799 Paralysis Diseases 0.000 description 3
- 210000000709 aorta Anatomy 0.000 description 3
- 210000004556 brain Anatomy 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 201000005577 familial hyperlipidemia Diseases 0.000 description 3
- 210000002683 foot Anatomy 0.000 description 3
- 210000003141 lower extremity Anatomy 0.000 description 3
- 230000000630 rising effect Effects 0.000 description 3
- 206010003178 Arterial thrombosis Diseases 0.000 description 2
- 206010065559 Cerebral arteriosclerosis Diseases 0.000 description 2
- 208000003164 Diplopia Diseases 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 102000007330 LDL Lipoproteins Human genes 0.000 description 2
- 108010007622 LDL Lipoproteins Proteins 0.000 description 2
- FINHMKGKINIASC-UHFFFAOYSA-N Tetramethylpyrazine Chemical compound CC1=NC(C)=C(C)N=C1C FINHMKGKINIASC-UHFFFAOYSA-N 0.000 description 2
- 208000005946 Xerostomia Diseases 0.000 description 2
- 201000007201 aphasia Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 208000029444 double vision Diseases 0.000 description 2
- 206010013781 dry mouth Diseases 0.000 description 2
- 208000013210 hematogenous Diseases 0.000 description 2
- 201000005851 intracranial arteriosclerosis Diseases 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 210000002254 renal artery Anatomy 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000003371 toe Anatomy 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 210000001364 upper extremity Anatomy 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 206010014513 Embolism arterial Diseases 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 206010024648 Livedo reticularis Diseases 0.000 description 1
- 206010049816 Muscle tightness Diseases 0.000 description 1
- 241001460678 Napo <wasp> Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 235000017276 Salvia Nutrition 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 206010040026 Sensory disturbance Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 208000008630 Sialorrhea Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000014604 Specific Language disease Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 210000002376 aorta thoracic Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001217 buttock Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000015111 chews Nutrition 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 210000001198 duodenum Anatomy 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000001105 femoral artery Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 210000003090 iliac artery Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003447 ipsilateral effect Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 210000000088 lip Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 210000002976 pectoralis muscle Anatomy 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- IKGXIBQEEMLURG-NVPNHPEKSA-N rutin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-NVPNHPEKSA-N 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000037152 sensory function Effects 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 239000004071 soot Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 201000005665 thrombophilia Diseases 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 229960003232 troxerutin Drugs 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pharmaceutical composition for treating cerebral thrombosis and myocardial infarction, which consists of clematis root, Tougu, notoginseng, teasel root, drynaria rhizome, Stephania delavayi, Cocculus trilobus, lycopodium clavatum and huperzia serrata. The pharmaceutical composition has the effects of benefiting qi, activating blood circulation, promoting tissue regeneration, removing blood stasis, dredging collaterals, inducing resuscitation and benefiting intelligence, and has obvious effects on treating cerebral apoplexy, cerebral hemorrhage, cerebral thrombosis, cerebral embolism, cerebral vasospasm, arteriosclerosis, subarachnoid hemorrhage and the like.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of hypertension and cerebral thrombosis.
Background technology
Hypertension is with blood fat height, blood arteriosclerosis, internal injury and the long-pending operation of blood stasis is unable, smooth of a specified duration the forming of blood.QI and blood fortuneization is incompetent, and myocardium negative and positive imbalance forms blood for the brain deficiency, becomes myocardial infarction and cerebral thrombosis.Endovascular thrombosis is " first killer " in crowd's fatal disease.In the cardiovascular and cerebrovascular disease, the disease of a kind of being called " acute arterial embolism " is arranged, in case take place, usually cause limbs or internal organs ischemic necrosis, the serious harm people's is healthy.Thrombosis is that the blood at any position solidifies in the blood circulation.It forms Fundamentals has three: one, the damage of blood vessel wall; The 2nd, blood flow rate slows down; The 3rd, change has taken place in blood constituent, such as hypercoagulability.Wherein the factor that thrombosis is had the greatest impact is the damage of blood vessel wall, and atherosclerosis is the principal element that causes vascular damaged.Structurally very unstable attached to thrombosis on heart or the main artery wall and arteriosclerosis plaque itself, can come off from tube wall under some situation, form embolus, embolus is along large artery trunks, medium-sized artery, arteriolar direction palpus blood flow, when the place ahead external caliber carefully when embolus can not pass through, embolus just is stuck, and forms arterial thrombosis.Spasm appears in the tremulous pulse at thromboembolism place immediately, makes external caliber littler, and thromboembolism is tightr.Typical case's performance of arterial thrombosis is that burst limbs or brothers refer to toe pain, blackening.Come from the embolus of renal artery ventral aorta below horizontal, volume is less, often goes to foot small artery place and produces thromboembolism.At first be that toes have an intense pain, pale, cool, stolidity.When the thromboembolism position was higher, the following position of thromboembolism arteriopalmus can disappear.Cyanosis of the skin, blue patch can occur subsequently, this moment, foot seemed not only dirty but also ugly, and therefore shape claims on " rubbish foot " as just passing through the soot behind the rain barefoot.The livedo reticularis at these positions can appear in thigh or buttocks small artery when getting involved, shank is got involved can " calf " severe pain.Skin, limbs blackening, necrosis can appear after several days.At this moment the pathological changes limbs oneself can not bring back to life again, had amputation only.Embolus permanent current from descending thoracic aorta is scurried to the feeding artery of abdominal organs, causes the serious pathological changes of certain internal organs.Such as: embolus enters the goldbeater's skin tremulous pulse and causes thromboembolism, can cause intestinal tube necrosis, perforation, peritonitis, serious occurred septic shock, threat to life.
For abundant position, the local thromboembolism that little embolus causes can cause perforation, causes agnogenic massive bleeding from upper digestive tract at blood such as stomach, duodenums.If embolus is stuck in and forms thromboembolism in the renal artery, normal occur burst, unmanageable hypertension, hematuria, renal failure.Mural thrombus volume ratio in the chambers of the heart is bigger, flows to be everlasting iliac artery, femoral artery etc. of lower limb and locates to form thromboembolism, easily causes the necrosis of whole piece lower limb.The chance that enters upper limb and brain from the embolus of heart or ascending aorta is many.It is similar with lower limb that embolus enters the thromboembolism performance that artery of upper extremity causes, the embolus that enters arteriae cerebri can form " apoplexy " that it has often been said, i.e. cerebral infarction or cerebral thrombosis.Sometimes the little embolus of heart goes out heart and promptly turns in coronary artery with blood flow is firm, can cause acute myocardial infarction.
Technology contents
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of cerebral thrombosis and myocardial infarction.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention is formed and proportioning following (by weight):
The deep 10-60 weight portion of Radix Clematidis 10-60 weight portion Radix Notoginseng 5-15 weight portion
Radix Dipsaci 3-10 weight portion Rhizoma Drynariae 10-60 weight portion thousand foldings pull out the 10-60 weight portion
Radix cocculi laurifolii 10-30 weight portion Herba Lycopodii 10-60 weight portion Photiniaserrulata rises the 10-60 weight portion
Optimum ratio of the present invention is:
The deep 30 weight portion Radix Notoginseng of Radix Clematidis 30 weight portions 10 weight portions
Radix Dipsaci 6 weight portion Rhizoma Drynariae 30 weight portions thousand foldings pull out 30 for weight portions
Radix cocculi laurifolii 20 weight portion Herba Lycopodiis 30 weight portion Photiniaserrulatas rise 30 weight portions
Pharmaceutical composition of the present invention also can add pharmaceutically acceptable excipient and make liniment, spray, pill, tablet, oral liquid, capsule, granule etc.
Drug combination preparation of the present invention has benefiting QI for activating blood circulation, continuous blood tissue regeneration promoting, blood stasis dispelling promote blood circulation, the have one's ideas straightened out effect of Fructus Alpiniae Oxyphyllae, and is remarkable to effects such as treatment apoplexy, cerebral hemorrhage, cerebral thrombosis, cerebral embolism, cerebral vasospasm, arteriosclerosis and subarachnoid hemorrhages.
Present composition preparation " essence of promoting blood circulation " point is wiped the clinical observation of treatment cerebrovascular accident:
The present invention's " essence of promoting blood circulation " is from the clinical treatment observation of year July in March, 1997 to 1999 to 56 routine cerebrovascular accident patients, and evident in efficacy, the checking situation is as follows:
1, clinical money is trembled
1.1 ordinary circumstance: male 21 examples, women 15 examples; Minimum 22 years old of age, maximum 84 years old.Wherein 40-60 year maximum, account for 78%;
1.2 the course of disease is the shortest 5 days, and is the longest 9 years, one of them accounts for month with interior person, and the person accounts for 19% more than 28%, one year; The course of disease accounts for 45% four months to the 9 years persons of not feeling any better, and wherein convalescent period accounts for 62%, and sequela stage accounts for 42%;
1.3 cerebral arteriosclerosis 23 examples, hypertension 12 examples, hyperlipidemia 6 examples, concurrent diabetes 4 examples.
1.4 clinical manifestation all is cases of cerebrovascular accident.Wherein blood pressure is in 160-180/90-110mmHg patient's 21 examples; Central 49 examples, paralysed 26 examples in left side wherein, right side paralysis 30 examples, muscular strength 0 degree 5 examples, I degree 2 examples, II degree 8 examples, III degree 14 examples, IV degree 36 examples.Aphasia 6 examples.Dysphagia and diet drink water to send out and choke, and cry 2 examples of putting on an air of cheerfulness by force.Numb 2 examples of Ipsilateral;
1.5 chemical examination detects: the high person of cholesterol: 5 examples, account for 46%, average is 246mg%, and triglyceride rising person 19 examples account for 39%, and average is 180mg%, and beta lipoprotein rising person 26 examples account for 42.5%, and average is 580mg%.
2, observation of curative effect
2.1 curative effect judging standard: medication is muscular strength and the equal no change of sign after two months, and the blood pressure blood fat is invalid at ascensionist still.Worsen: after medication course of treatment, not only symptom do not alleviate, increase the weight of on the contrary, and also have again the bolt tendency to occur.Effectively: muscular strength increases the I degree, other symptoms progress person, wiping muscular strength 1 course of treatment no change still again.Produce effects: muscular strength increases the II degree, the walker of standing separately, the life of can taking care of oneself under others assists.Be almost recovered: muscular strength, language, intelligence are recovered normally substantially, the life of taking care of oneself, and can do housework or working work.
2.2 therapeutic outcome:
Limbs recover: recover 17 examples substantially, account for 30.2%: produce effects 33 examples account for 62.5%; Effective 36 examples account for 6.3%: improvement is in various degree all arranged after the medication.Have indivedual signs to recover 4 examples, hands can be held thing 5 examples, 5 examples of can oneself relieving oneself.There are 18 examples to recover normal behind the 21 routine hypertension therapeutics.
Blood Lipid: cholesterol is 193mg% in 2 examples, and 63mg% on average descends; Triglyceride average in 19 examples is 174mg%, and 44mg% on average descends; Average is 451 in beta lipoprotein 26 examples, and 60mg% on average descends.
3, model case 1 Zhang, man, 45 years old, cadre.Diagnosis and treatment on June 23 in 1998.On business poor overtired, feel left side face numbness, facial hemiparalysis suddenly on the way, left side half body limitation of activity, stride is slow, dysphasia, promptly give certain hospital to rescue, be in hospital 1 year, hemiplegia day by day increases the weight of, family members invite inventor's diagnosis and treatment, examine and see arteries and veins Shen Xian, light red tongue, tongue is white little greasy, " institute of heresy gathers, and its gas must be empty ", the deficiency of vital energy is hematogenous blockage then, and the venation stasis of blood stagnates.Mild case and facial hemiparalysis, unfavorable, the costive meridians syndrome of half body limbs of speech occur.Arteries and veins Shen, light red tongue are for wrapping up in empty levying.Control suitable invigorating qi and benefiting blood, the repercussive collateral dredging.Intend acupuncture points such as the strong medicine of the present invention " essence of promoting blood circulation " point is wiped in Baihui, the sun, windy mansion, Yamen, philtrum, Quze, connected valleys, the committee, Opened Hollow, spring, every day 2 times, continuity point was wiped 10 days, patient face is conscious comfortable, language is gradually fluent, but mouthful eye folding is not also not freely, and stride is owed flexibly, arteries and veins Shen Chi.Shen is that the deficiency of vital energy does not reach, and is hematogenous blockage late, still by the treatment of former method, strengthens in Quze, connected valleys, the committee, Opened Hollow acupuncture point dose is with the warming the meridian blood stasis dispelling, go into network and search wind, connect a wiping 10 days again, subjective effect is remarkable, and mouthful eye folding freely, only feel xerostomia, have a dizzy spell that arteries and veins Shen is number slightly, white and thin fur.Slightly subtract extremity cave dose, add Baihui, temporal dose, with the fresh breeze YIN nourishing.Advance 10 days Hous again, dizzy, xerostomia alleviates, and leg movements is near normal, and arteries and veins Shen is number slightly, white and thin fur, and after continuation was pasted and wiped 1 course of treatment, all diseases were removed greatly, did not stay Hou to lose disease.
Model case 2: what certain, man 43 years old, workman.First visit on August 25 in 1998.Burst right side body has an intense pain before 5 days, and limbs are wriggled unconsciously, take out contraction, facial hemiparalysis, dysphonia, chest muscle little pastiness purple in right side is lived Napo County hospital surgery treatment and was not imitated in 5 days, and the state of an illness increases the weight of gradually, hospital's notice of being critically ill down can only be awaited one's doom, and changes and asks our diagnosis and treatment.Check: 36.8 ℃ of body temperature, blood pressure 190/110mmHg breathes pulse frequency 86 times/minute 20 times/minute.Chest X-rays: the heart is aortic type, rises master pulse, right ventricle expansion.Examination of ocular fundus: double vision nethike embrane arteriosclerosis.Renal function is normal.Red tongue, tongue are greasy in vain, stringy and rolling pulse.Card is the wind-phlegm superinverse, controls suitable suppressing the hyperactive liver to arrest the wind syndrome, relieving convulsion, removing heat-phlegm.Wipe with the strong medicine of the present invention " essence of promoting blood circulation " point: in Baihui, the sun, bl, Quze, connected valleys, Huantiao, the committee, acupuncture points such as Opened Hollow, spring, dried then easily it, be regardless of number of times, the 2nd day morning, after discharging a beach hemafecia during patient's defecation, subjective symptoms all disappears, and blood pressure has been reduced to 140/95mmHg, connects a wiping bleeding from anus pressure drop in 10 days again to 138/85mmHg.Follow up a case by regular visits to after two months, all right, do not see recurrence.
Example 2: the week certain, man, 48 years old, peasant.JIUYUE in 1996 first visit on the 25th.Suddenly sensation stiff tongue before 7 days, it is not smoothgoing to speak, facial hemiparalysis gradually, hemiplegia of limb.Check: body obesity, sanity, left side face numbness, nasolabial fold is smooth, and slobbering is more than, and tongue body does not relax.The left limb hemiplegia need not, sensory disturbance.36.8 ℃ of body temperature are breathed 20 times/minute, blood pressure 140/95mmHg, pulse 95 times/minute.Lab testing: cerebrospinal pressure is normal, water white transparency.The total fat 760mg% of blood, T-CHOL 210mg%.The Chest X-rays heart is aortic type, and aorta is broadening slightly.Examination of ocular fundus: double vision nethike embrane arteriosclerosis.The red tongue point is red, and tongue is greasy in vain, stringy and rolling pulse.Strengthen acupuncture points such as medicine " essence of promoting blood circulation " point is wiped in Baihui, the sun, Quze, connected valleys, Huantiao, the committee, Opened Hollow, spring with the present invention, the degree of being with the heating, every day 3 times.Further consultation after 5 days, headache alleviates, and chews better, and mouth is sialorrhea not, and numb limbs and tense tendons alleviates, and wipes after 5 days again.Language is more clear, leans on to turn to toddel about 20 steps blood pressure 135/95mmHg.Continue the some wiping and strengthen functional exercise after 10 days, symptom alleviates greatly, and it is normal that the left side nasolabial fold recovers, and the face sensory function is recovered, and language is smoothness substantially.Wipe again after 20 days, action freely, symptom disappears substantially, blood pressure 135/95mmHg, every experimental check, situation is all more preceding for well.Advise it to continue point and wiped 20 days, and note the conditioning life, work and rest is suitable.Follow up a case by regular visits to May in this year, all right, do not see recurrence
4, discuss
4.1 mechanism is inquired into: the net cerebrovascular accident belongs to the category of the traditional Chinese medical science " apoplexy ", it forms reason three; One in the blood vessel blood stasis due to qi deficiency; Two is not continuous at meridian qi and blood; Three at yang blood and qi from keeping.So its pathogenesis can reduce negative and positive thermal transfer, blood stasis due to qi deficiency; QI and blood is not continuous, and passages through which vital energy circulates is obstructed.Should be on the treatment rule with benefiting QI for activating blood circulation, eliminating blood stasis and smoothing collaterals, continuous blood new life is along connecing blood vessels, the Fructus Alpiniae Oxyphyllae of having one's ideas straightened out, YIN and YANG balance regulating.Strong medicine " essence of promoting blood circulation " acupuncture point point is wiped the treatment cerebrovascular accident, has tangible raising muscular strength, recovers the function of paralyzed limbs, and the effect of hypertension and hyperlipemia is arranged again.Side's medicine is formed no incompatibility, and medicine is the deep extremely strong traumatic injury medicine that is, the effect nothing is contained partially, and dose greatly also has no side effect, so but external is beneficial to functional rehabilitation.
4.2 the medicine of strong medicine " essence of promoting blood circulation " is different from Zhitan medicine commonly used, and is few with the product that dispel the wind, and is principal agent with a small amount of Radix Clematidis, Herba Lycopodii just, this is our characteristics, and the Radix Dipsaci blood-activating kidney-tonifying is joined in the rising of TOUGUFENG replenishing qi and promoting blood flow, strengthening bone and muscle and hypertension and hyperlipemia.Radix Flemingiae Philippinensis is joined the logical operation of Rhizoma Drynariae benefiting QI for activating blood circulation a surname.Radix Clematidis, Herba Lycopodii have to search and pick whole body meridians, and continuous blood tissue regeneration promoting is along connecing blood vessels, and the merit of the newborn venation of traffic makes QI and blood circulation as ring for no reason.TOUGUFENG is carried Radix Clematidis, Herba Lycopodii, Radix Flemingiae Philippinensis, Radix Dipsaci, Radix Notoginseng and is infiltrated through brain and connect disease institute, and the stasis of blood of shabby blood is long-pending, holds up new life's blood, short QI and blood mediation, and YIN and YANG in a relative equilibrium, the extremity bones of the body collectively is normal again.Its TOUGUFENG, Radix Flemingiae Philippinensis, Rhizoma Drynariae bring high blood pressure down obviously lasting.Radix Clematidis, Herba Lycopodii, Radix cocculi laurifolii, Radix Notoginseng, Radix Dipsaci; The effective cholesterol reducing content of Caulis et Folium piperis.
5, efficacy evaluation is observed from data and is found out that the strong medicine of the present invention " essence of promoting blood circulation " is better to the recovery effects of muscular strength, and effective percentage reaches 89%, is higher than liquid salvia, ligustrazine, Radix Paeoniae Rubra 801 (81%), the troxerutin (82%) of present report; Eliminating thrombus (72%).The effect that hypertension and hyperlipemia is arranged simultaneously, the cerebrovascular accident that causes because of arteriosclerosis for control has certain curative effect.
Following embodiment all can realize the effect of above-mentioned experimental example.
Embodiment 1
The deep 30g Radix Notoginseng of Radix Clematidis 30g 10g
Radix Dipsaci 6g Rhizoma Drynariae 30g thousand foldings pull out 30g
Radix Cocculi Orbiculati 20g Herba Lycopodii 30g Photiniaserrulata rises 30g
Said medicine technology is routinely made liniment, every day three times, wipes 3 milliliters at every turn.
Embodiment 2
The deep 30g Radix Notoginseng of Radix Clematidis 30g 10g
Radix Dipsaci 6g Rhizoma Drynariae 30g thousand foldings pull out 30g
Radix Cocculi Orbiculati 20g Herba Lycopodii 30g Photiniaserrulata rises 30g
Said medicine technology is routinely made spray.Spray every day three times, the affected part brushes with the feverish skin degree of being, sprays 2 milliliters at every turn.
Claims (3)
1, a kind of pharmaceutical composition for the treatment of cerebral thrombosis and myocardial infarction is characterized in that said composition mainly is to be made by following crude drug:
The deep 10-60 weight portion of Radix Clematidis 10-60 weight portion Radix Notoginseng 5-15 weight portion
Radix Dipsaci 3-10 weight portion Rhizoma Drynariae 10-60 weight portion thousand foldings pull out the 10-60 weight portion
Radix cocculi laurifolii 10-30 weight portion Herba Lycopodii 10-60 weight portion Photiniaserrulata rises the 10-60 weight portion.
2, pharmaceutical composition according to claim 1 is characterized in that said composition mainly is to be made by following crude drug:
The deep 30 weight portion Radix Notoginseng of Radix Clematidis 30 weight portions 10 weight portions
Radix Dipsaci 6 weight portion Rhizoma Drynariae 30 weight portions are done folding and are pulled out 30 for weight portions
Radix cocculi laurifolii 20 weight portion Herba Lycopodiis 30 weight portion Photiniaserrulatas rise 30 weight portions.
3, pharmaceutical composition according to claim 1 and 2 is characterized in that said composition also can add pharmaceutically acceptable excipient and make arbitrary dosage form in liniment, spray, pill, tablet, oral liquid, capsule, the granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03149985 CN1283279C (en) | 2003-08-01 | 2003-08-01 | A pharmaceutical composition for treating cerebral thrombosis and myocardial infarction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03149985 CN1283279C (en) | 2003-08-01 | 2003-08-01 | A pharmaceutical composition for treating cerebral thrombosis and myocardial infarction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1579454A true CN1579454A (en) | 2005-02-16 |
| CN1283279C CN1283279C (en) | 2006-11-08 |
Family
ID=34579745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03149985 Expired - Fee Related CN1283279C (en) | 2003-08-01 | 2003-08-01 | A pharmaceutical composition for treating cerebral thrombosis and myocardial infarction |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1283279C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104644937A (en) * | 2015-03-17 | 2015-05-27 | 山东大学齐鲁医院 | Spray for treating vasospasm and preparation method of spray |
| CN109172655A (en) * | 2018-11-29 | 2019-01-11 | 黄海平 | One kind promote blood circulation essence and its preparation process |
-
2003
- 2003-08-01 CN CN 03149985 patent/CN1283279C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104644937A (en) * | 2015-03-17 | 2015-05-27 | 山东大学齐鲁医院 | Spray for treating vasospasm and preparation method of spray |
| CN109172655A (en) * | 2018-11-29 | 2019-01-11 | 黄海平 | One kind promote blood circulation essence and its preparation process |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1283279C (en) | 2006-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1706441A (en) | Arthralgia treating plaster | |
| CN103520366B (en) | Be used for the treatment of the Chinese medicine of spastic hemiplegia after stroke | |
| CN102441154B (en) | A kind of Chinese medicine preparation for the treatment of gout | |
| CN1283279C (en) | A pharmaceutical composition for treating cerebral thrombosis and myocardial infarction | |
| CN104491776A (en) | Tradtional Chinese medicine preparation for treating chronic limb arteriosclerosis obliterans and preparation method thereof | |
| CN102370896B (en) | Medicine for treating cerebral thrombosis | |
| CN102309558A (en) | Traditional Chinese medical preparation for treating hypertension | |
| CN102552715B (en) | Chinese medicinal composition, medicine containing Chinese medicinal composition and preparation method of medicine | |
| CN102309561B (en) | Pharmaceutical composition used for preventing and treating urarthritis and hyperuricemia | |
| CN109865010A (en) | The liquid medicine and preparation method thereof for treating rheumatic arthritis, osteoproliferation and protrusion of lumber intervertebral disc | |
| CN108379510A (en) | A kind of Chinese medicine composition for treating angiocardiopathy | |
| CN1325103C (en) | Tendon and bone strengthening capsule | |
| Verma et al. | A CLASSICAL AYURVEDIC MANAGEMENT OF JALODARA (ASCITES) | |
| CN108096536A (en) | A kind of Chinese medicine composition for treating hemiplegia | |
| CN107961342A (en) | A kind of Chinese medicine composition for treating hemiplegia and preparation method thereof | |
| Jaju et al. | Ayurvedic management of Vatarakata (gout)-A case report | |
| CN1111038C (en) | Chinese patent medicine for curing thrombotic disease | |
| CN105106855A (en) | Traditional Chinese medicine preparation for treating apoplexy sequela | |
| CN110694014A (en) | A composition for preventing and treating thrombosis | |
| CN104096112A (en) | Traditional Chinese medicine composition for treating angina pectoris | |
| CN103655993B (en) | A kind of Chinese medicine for the treatment of apoplexy and preparation method thereof | |
| CN101396525B (en) | Traditional Chinese medicine preparation for treating cerebrovascular disease | |
| CN105535871A (en) | Traditional Chinese medicine plaster for treating cervical muscle type cervical spondylosis | |
| Carmen et al. | HEMIPARESIS AFTER ISCHEMIC STROKE. | |
| CN1316987C (en) | Recipe of plaster for treating cervical vertebra and lumber vertebra arthritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20061108 Termination date: 20130801 |