CN1111038C - Chinese patent medicine for curing thrombotic disease - Google Patents

Abstract

The present invention discloses a Chinese patent medicine for treating thrombotic diseases, which comprises the components of 400 to 600 portions by weight of hirudo, 56 to 84 portions by weight of bezoar, 56 to 84 portions by weight of dragon blood, 240 to 360 portions by weight of earthworm, 16 to 24 portions by weight of borneol, 24 to 36 portions by weight of gleditschia horrida and 1.6 to 2.4 portions by weight of musk. The present invention has reasonable match of the components, has the functions of restoring consciousness, inducing resuscitation, dissolving thrombus, increasing cerebral blood flow and accelerating collateral branch blood circulation, has favorable curative effects on hemiplegia, aphasia, obnubilation, senile dementia, etc. caused by apoplexy, the sequelae of craniocerebral operations, brain trauma, etc., and is a good Chinese medicinal preparation for dissolving thrombus, restoring consciousness and treating thrombotic diseases.

Description

A kind of Chinese patent medicine for the treatment of thrombotic disease

The present invention relates to Chinese patent drug technique field, relate to a kind of Chinese patent medicine for the treatment of thrombotic disease specifically.

Cerebral thrombosis, cerebral embolism are commonly called as apoplexy, be commonly encountered diseases, the frequently-occurring disease of middle-aged and elderly people, patient suddenly faints, syncope or the mouth eye is crooked, spoken unfavorable, numb limbs and tense tendons, hemiplegia appear in severe patient, malpractice is many can to stay sequela, disability rate is higher, is a big pertinacious disease medically.The medicine of existing treatment cerebral thrombosis as MAILUONING, troxerutin etc., mostly is that Western medicine preparation, curative effect are slow, and Western medicine can have side effects to health, adopts the Chinese patent medicine preparation of pure Chinese herbal treatment thrombotic disease still rare at present.

The object of the present invention is to provide a kind of can consciousness-restoring and orifice-opening, thrombus, cerebral blood flow increasing amount, acceleration side prop up the Chinese patent medicine of blood fortune circulation treatment thrombosis disease.

The objective of the invention is to be achieved through the following technical solutions; a kind of Chinese patent medicine for the treatment of thrombotic disease; be by (by weight) Hirudo 400-600 part, Calculus Bovis 56-84 part, Sanguis Draxonis 56-84 part; Pheretima 240-360 part, Borneolum Syntheticum 16-24 part, Fructus Gleditsia 24-36 part, the medicament that Moschus 1.6-2.4 part is made according to the conventional preparation technology of Chinese medicine.

Each the component optimum ratio scheme of Chinese patent medicine that realizes the object of the invention is: (by weight) Hirudo 450-550 part, Calculus Bovis 63-77 part, Sanguis Draxonis 63-77 part, Pheretima 270-330 part, Borneolum Syntheticum 18-22 part, Fructus Gleditsia 27-33 part, Moschus 1.8-2.2 part.

Each component optimum proportion scheme of Chinese patent medicine of realizing the object of the invention is: 500 parts of (by weight) Hirudos, 70 parts of Calculus Boviss, 70 parts of Sanguis Draxonis, 300 parts of Pheretimas, 20 parts of Borneolum Syntheticums, 30 parts in Fructus Gleditsia, 2 parts in Moschus.

The property of medicine and the pharmacology of the used Chinese herbal medicine of respectively distinguishing the flavor of:

Hirudo, property hardship, one-tenth, flat are returned Liver Channel, but removing blood stasis contains hirudin in the salivary gland of fresh Hirudo, is a kind of anticoagulative substance, can stop the effect of thrombin, hinder blood coagulation, studies show that the 20mg hirudin can stop solidifying of 100g human blood fibronectin; Also contain heparin, antithrombotic element in the Hirudo, can be used for expanding blood capillary and increase hemorrhage, to the control thrombosis play an important role.

Calculus Bovis; property hardship, cold, GUIXIN, Liver Channel, its gas fragrance have the effect of dispelling wind and relieving convulsion, removing heat from the heart to restore the consciousness eliminating phlegm; record in " book on Chinese herbal medicine is looked for the truth " " ... separate heart channel pathogenic heat with this; sensible sharp expectorant arresting convulsion, and ... diseases such as aphasia due to apoplexy ", modern medicine study shows; Calculus Bovis contains cholic acid, deoxycholic acid etc.; also contain several amino acids, calmness, spasmolytic, blood vessel dilating and adrenolytic are arranged, can make blood pressure drops.

Sanguis Draxonis, property is sweet, become, put down, return liver, pericardium channel, the effect that the promoting blood circulation to remove blood stasis pain relieving is arranged for oral administration, carry in " Newly Revised Canon of Materia Medica " " controlling sudden attack of pain in the chest and abdomen, hemorrhage, the removing mass blood of incised wound; the pain relieving granulation promoting ", Sanguis Draxonis contains dracorhodin, demethyl dracorhodin, demethyl dracorubin and flavonol, resinic acid etc., and significantly anticoagulant prevents thrombosis.

Pheretima claims LUMBRICUS, Lumbricus again, and property is salty, tremble with fear, return liver, lung, urinary bladder channel, and the effect of endogenous wind stopping heat clearing away, relieving convulsion collateral dredging is arranged; It includes lumbrifebrine, lumbricin, reach nitrogen substance, xanthine, adenine, guanine, choline etc., do zoopery (as white mice, rabbit) with its tincture, hot dipping agent, alcohol extract etc., show slow and persistent blood pressure lowering effect, and tangible calmness, anticonvulsant action are arranged, lumbricin also has the effect of haemolysis, thrombolytic, is usually used in treating apoplexy sequela such as calentura frightened is jerked, arthralgia, hemiplegia.

Borneolum Syntheticum is divided into three kinds of borneols, BORNEOLUM SYNTHETICUM, Blumeae preparatum Tabellae, and this medicine is good with borneol.Its property suffering, hardship, be slightly cold, GUIXIN, spleen, lung meridian, can loose part of the body cavity above the diaphragm housing the heart and lungs stagnated fire and the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain can be used for treating the disease that apoplexy syncope due to accumulation of phlegm, middle gas, attacked by pestiferous factors soldier are so fainted; Borneol contains left-handed Borneolum Syntheticum, contains sesquiterpenes such as caryophyllene, beta-elemene again, and triterpenoid such as oleanolic acid, alphitolic acid, Borneolum Syntheticum are aromatic, erythrodiol, can well see through blood brain barrier, and the time of accumulating in brain is long, measure also quite high, to the treatment thrombotic disease play an important role.

Moschus, property suffering, temperature, GUIXIN, spleen channel belong to the refreshment medicine of having one's ideas straightened out together with Borneolum Syntheticum, and it contains muscone, and low dose of Moschus has excitation to nervus centralis, can alleviate cerebral edema significantly, strengthens the toleration of nervus centralis to cerebral anoxia, improves cerebral circulation.

Fructus Gleditsia, property suffering, salty, warm is returned lung, large intestine channel, sensible, the switching refreshment of can eliminating the phlegm, the centering wind-phlegm is fainted (traditional Chinese medical science claims phlegm resistance), brain lacks the epilepsy person, and therapeutic effect is especially remarkable, is equal to usefulness with Moschus, and the mind of can reviving is as a means of first aid.

Chinese medicine has the theory of " control wind and control blood earlier, the blood sector-style is from going out ", and in the used component of the present invention, Hirudo, Sanguis Draxonis have the effect of promoting blood circulation to remove blood stasis, can dredge blood vessels, expansion blood capillary, blood flow increasing, anticoagulant, prevents thrombosis; Calculus Bovis, Pheretima have the effect of endogenous wind stopping heat clearing away, and faint tic, infantile convulsion lunatic has tangible calmness, hypotensive activity to convulsion; Borneolum Syntheticum, Moschus, Fructus Gleditsia are the awaking drug of being open to the custom, and its hot perfume (or spice) is warded off dirty, and the popular feeling exorcises evil spirits, and intestinal stasis relieving is stopped up in more can eliminate the phlegm scale removal, a surname of Fructus Gleditsia, makes stupor person recover mind; The collocation of each component rationally has better curative effect to diseases such as the hemiplegia that causes because of apoplexy, craniocerebral operations sequela, cerebral trauma etc., aphasia, obnubilation, alzheimer disease, is a kind of extraordinary thrombolytic refreshment Chinese medicine preparation for the treatment of thrombotic disease at present.

Clinical observation research:

Chinese patent medicine clinical practice of the present invention is in the past few years treated cerebral thrombosis, cerebral embolism, craniocerebral operations sequela, brain atrophy etc. and is all obtained better curative effect, now provides as follows with 226 routine patient treatment data:

226 routine patients, cerebral thrombosis 135 examples wherein, cerebral embolism 88 examples, male's 125 examples, women's 101 examples, age 32-80 year, the state of an illness 1 month-3 years.

Clinical manifestation: 226 routine patients all have hemiplegia of limb symptom in various degree, and 86 illustrative phrases speech is unfavorable, and 96 examples suffer from hypertension, and 45 examples suffer from diabetes.

Diagnosis basis: according to the diagnosis and treatment of cerebrovascular diseases main points of Chinese Medical Association's cerebrovascular academic conference revision for the second time in 1986, and " traditional Chinese medical science apoplexy emergency case diagnosis and treatment standard " of the revision in 1988 of the national medical association of reference, all patients all make head CT or MRI makes a definite diagnosis.

More than all patients be divided into two groups by the state of an illness:

Matched group according to patient's situation conventional therapy of suiting the medicine to the illness, adopts mannitol, doubly quiet of his pyridine sodium chloride, MAILUONING, troxerutin, lamp writing paper florigen etc.;

The treatment group adds Chinese medicine capsule of the present invention on the basis of treatment of control group scheme, every day 3 times, each 6, one after each meal.

Criterion of therapeutical effect:, observe clinical neurological functional recovery situation, and propose according to this with reference to clinical neurologic deficit of stroke patients scoring and the rehabilitation standard that second the cerebrovascular academic conference in the whole nation in 1986 passed through:

1, basic function recovery from illness: neurological deficits score reduces 90-100%;

2, significantly carry out: neurological deficits score reduces 46-89%;

3, progressive: neurological deficits score reduces 18-45%;

4, no change: neurological deficits score reduces or increases in 18;

5, worsen: neurological deficits score increases more than 18%.

Treatment group and matched group are all observed contrast according to the neurological deficits score standard before and after treatment,

After treatment group patient adds Chinese medicine capsule of the present invention, patient's numb limbs and tense tendons, pain all have improvement in various degree, particularly limbs and language function to recover more obvious, Comparison of therapeutic sees the following form:

This function of example base recovery from illness marked improvement progress no change worsens 113 31 32 33 15 2 84% treatments of total effective rate matched group and organizes 113 46 53 10 40 96%

Can find out that from last table treatment group and matched group have tangible difference, basic function recovery from illness: treatment group 40%, matched group 27%; Marked improvement: treatment group 46%, matched group 28%; Total effective rate: treatment group 96%, matched group 84%.

In order to understand better and to implement, the present invention will be further described with embodiment below:

Example 1, water intaking trematodiasis 400g puts into microwave oven with 80 ℃ of low-temperature bakes 4 minutes, and Yin Gaowen can destroy important active ingredient---the hirudin that includes, and low temperature can disinfection, oven dry, can protect its property of medicine again, pulverizes after the oven dry, and mistake 80 mesh sieves are got its smart powder; Get Pheretima 240g,, pulverize, cross 100 mesh sieves sieve and remove too much fiber with 100 ℃ of bakings of temperature in the microwave oven 2 minutes; Get Fructus Gleditsia 24g, high-temperature baking 4 minutes, messenger drug baked coke, sustainability are mixed together and grind into powder with Borneolum Syntheticum 16g, Sanguis Draxonis 56g again, cross 80 mesh sieves; Get Moschus 1.6g (can directly adopt the pharmaceutical factory of traditional Chinese medicine produce finished product medicamental pulverata), artificial Calculus Bovis 56g (this medicine adopts the artificial Calculus Bovis, low price, and dispatch from the factory and be superfine powder, need not handle); With above-mentioned various medicated powder mixing and stirring, incapsulate by every 0.4g and to get final product.

Example 2. water intaking trematodiasis 600g put into the microwave oven low-temperature bake 5 minutes, pulverized after the oven dry, crossed 100 mesh sieves and got its smart powder; Get Pheretima 360g, middle temperature baking 3 minutes is pulverized, and crosses 100 mesh sieves and gets smart powder; Fructus Gleditsia 36g, high-temperature baking baked coke in 5 minutes mixes with Borneolum Syntheticum 24g, Sanguis Draxonis 84g and to grind into powder, crosses 80 mesh sieves; Get artificial Calculus Bovis 84g, Moschus 2.4g; With above-mentioned all medicated powder mixing and stirring, incapsulate by every 0.4g and to get final product.

Example 3, water intaking trematodiasis 450g, low-temperature bake 4 minutes is pulverized, and crosses 100 mesh sieves and gets its smart powder; Pheretima 270g, middle temperature baking 3 minutes is pulverized, and crosses 100 mesh sieves; Fructus Gleditsia 27g, the high-temperature baking baked coke mixes with Borneolum Syntheticum 18g, Sanguis Draxonis 63g and to grind into powder, crosses 80 mesh sieves; Get Moschus 1.8g, artificial Calculus Bovis 63g with above-mentioned medicated powder mixing and stirring, incapsulates by every 0.4g and to get final product.

Example 4, water intaking trematodiasis 550g put into the microwave oven low-temperature bake 5 minutes, and crushing screening is got its smart powder; Pheretima 330g, middle temperature baking 3 minutes, crushing screening is got smart powder; Fructus Gleditsia 33g, high-temperature baking baked coke in 5 minutes is mixed and grinds into powder with Borneolum Syntheticum 22g, Sanguis Draxonis 77g, sieves; Get artificial Calculus Bovis 77g, Moschus 2.2g with each medicated powder mixing and stirring, incapsulates by every 0.4g and to get final product.

Example 5, water intaking trematodiasis 500g, microwave oven low-temperature bake 5 minutes, crushing screening is got smart powder; Pheretima 300g, middle temperature baking 3 minutes, crushing screening is got smart powder; Fructus Gleditsia 30g, the high temperature baked coke mixes with Borneolum Syntheticum 20g, Sanguis Draxonis 70g and to grind into powder, sieves; Artificial Calculus Bovis 70g, Moschus 2g with above-mentioned medicated powder mixing and stirring, incapsulates by every 0.4g and to get final product.

Case 1:

Beam * *, man, 56 years old, first visit date: on March 15th, 1998

Right half body quadriplegia, aphasia 15 days

The patient before 15 days morning get up that suddenly sensation is dizzy, headache, right half body limb activity is ineffective, and is spoken unfavorable.Suddenly remove certain examination in hospital, the CT diagnosis: left side brain large tracts of land infraction, hospitalization, it is big to give treatments 15 such as MAILUONING, ligustrazine, mannitol, and the fruit spy that do not take effect seeks medical advice.

Look into when examining: old age, the male, refreshing clear, the skew to the right that lolls, blood pressure: 20/12kpa, the paralysis of right side limbs completeness, spoken unfavorable, defecation is normal.

Treatment: abide by the top treatment, give capsule oral of the present invention, every day 3 times, each 6, go up disease after 5 days and all take a favorable turn, but right side upper and lower extremities gentle activity, and spoken language is more fluent, after continuing to take first quarter moon, the oral medication but out-of-bed activity, band capsule are gone home, the check of returning after February, be almost recovered, good so far.

Case 2:

Woods *, the man, 68 years old, the peasant, the first visit date: on December 25th, 1998

Dizziness, headache, movable ineffective 6 days of left half body

Patient 6 is big preceding dizzy from sensation when the work of field, and headache is unable all over the body.In the first visit of home town commune hospital is cerebral thrombosis, and hospitalization gives troxerutin, ligustrazine etc. and adds doubly quiet of his pyridine sodium chloride, and the fruit that do not take effect transfers and seeks medical advice.

Check: old age, the male, mind is clear, the bilateral isocoria, the tip of the tongue that lolls is offset left, and spoken language is more fluent, left side half body activity is ineffective, it is poor that upper limb is held power, and flat the stretching slightly of two upper limb trembled, and it is unstable to walk, but two people help gentle activity, each neural reflex exists, blood pressure: 19/11kpa, and the CT head is checked: right side cerebral lacunae cerebral infarction, brain atrophy.

Treatment: because of the patient requires to be with the medicine treatment of going home, get capsule 100g * 2 bag then, advise its every day 3 times, each 6, one after each meal.The further consultation of returning after two weeks, headache, dizzy, the numb transference cure of limb, I walks.The patient continues to fully recover with after top treatment January, does not see recurrence so far.

Chinese medicine capsule of the present invention, production process is simple, curative effect is reliable, except that cerebral thrombosis, cerebral embolism, brain atrophy, apoplexy sequela are had the obvious therapeutic action, experimentation shows also can treat diseases such as coronary heart disease, thrombophlebitis, and to preventing cardiovascular and cerebrovascular disease that good effect is arranged, clinical practice is extensive, and fine potentiality to be exploited is arranged.

Claims (3)

1, a kind of Chinese patent medicine for the treatment of thrombotic disease is characterized in that it is Hirudo 400-600 part by by weight, Calculus Bovis 56-84 part, and Sanguis Draxonis 56-84 part, Pheretima 240-360 part, Borneolum Syntheticum 16-24 part, Fructus Gleditsia 24-36 part, Moschus 1.6-2.4 part is formed.

2, a kind of Chinese patent medicine for the treatment of thrombotic disease according to claim 1 is characterized in that described each proportioning raw materials counts Hirudo 450-550 part, Calculus Bovis 63-77 part by weight; Sanguis Draxonis 63-77 part, Pheretima 270-330 part, Borneolum Syntheticum 18-22 part; Fructus Gleditsia 27-33 part, Moschus 1.8-2.2 part.

3, a kind of Chinese patent medicine for the treatment of thrombotic disease according to claim 1 is characterized in that described each proportioning raw materials counts 500 parts of Hirudos, 70 parts of Calculus Boviss, 70 parts of Sanguis Draxonis, 300 parts of Pheretimas, 20 parts of Borneolum Syntheticums, 30 parts in Fructus Gleditsia, 2 parts in Moschus by weight.