CN108379510A - A kind of Chinese medicine composition for treating angiocardiopathy - Google Patents
A kind of Chinese medicine composition for treating angiocardiopathy Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine composition for treating angiocardiopathy, includes the substance of following weight proportion：50 70 parts of leech, 100 300 parts of Radix Salviae Miltiorrhizae, 80 150 parts of safflower, 5 10 parts of borneol, 20 60 parts of curcuma zedoary, 30 60 parts of turmeric.Have the characteristics that at low cost, preparation is easy, toxic side effect is small, significant in efficacy, uneasy to recur.
Description
Technical field
The present invention relates to tcm fields, specifically, being related to a kind of medicament for treating cardiovascular and cerebrovascular disease.
Background technology
Angiocardiopathy, also known as circulation system disease, are a series of diseases for being related to the circulatory system, and the circulatory system refers to people
Internal hemophoric organ and tissue, include mainly heart, blood vessel (artery, vein, capilary), generally all with artery sclerosis
It is related.Coronary heart disease is then formed when this pathological development to heart coronary artery, including：Angina pectoris, myocardial infarction and acute dead
It dies.It is the essence of cardiovascular disease incidence that Chinese medicine, which thinks that heart disease belongs to scopes, the qi deficiency to blood stasis such as " obstruction of qi in the chest ", " pained " more,.
In recent years, with the improvement of people's living standards, and diet not science, it is irregular phenomena such as generally existing,
Cardiovascular disease incidence rate obviously increases.Usually the body of patient is caused greatly to injure by operative treatment now, be not easy
Rehabilitation；Perform the operation simultaneously (such as cardiovascular stents operation) postoperative complications (such as foreign body in heart obstruction etc.) risk very
Greatly, and average family faces also powerlessly to undertake when the high cost of cardiovascular stents.Though and the method for existing drug therapy
It so can also tell on to corresponding illness, but offer limited effectiveness, side effect is more, can be to patient often while controlling illness
Other organs generate damage, in addition, Long-term taking medicine is costly, and patient's Long-term taking medicine also will produce drug resistance, meeting again after drug withdrawal
Recurrence, cannot be effected a radical cure.
Therefore, clinically it is badly in need of the drug that a kind of energy of offer is at low cost, risk is small while therapeutic effect is good, recurrence rate is low to come
Treat angiocardiopathy.
Invention content
To solve the above-mentioned problems, present invention is primarily aimed at provide a kind of Chinese medicine group for treating angiocardiopathy
Object is closed, the Chinese medicine of following weight proportion is included：50-70 parts of leech, 100-300 parts of Radix Salviae Miltiorrhizae, 80-150 parts of safflower, borneol 5-10
Part, 20-60 parts of curcuma zedoary, 30-60 parts of turmeric.
It is another aspect of the invention to provide it is a kind of for treat angiocardiopathy Chinese medicine composition preparation method,
Wherein, the method includes：Step (1) leech, Radix Salviae Miltiorrhizae, safflower, borneol, curcuma zedoary, turmeric carry out high-temperature sterilization；And step
(2) it weighs in proportion in step (1) by the Chinese medicine of disinfection, is ground into fine powder, cross 800 mesh sieve, be packed into No. 0 capsule.
Another aspect of the present invention is to provide above-mentioned Chinese medicine composition in the drug for preparing treatment angiocardiopathy
Using.
Advantageous effect:
Chinese medicine composition provided by the present invention can improve systemic blood circulation, dissipating blood stasis with potent drugs, Xuan Tong in the shorter time
Heart arteries and veins, regulating qi-flowing for relieving pain, inducing resuscitation of having one's ideas straightened out, be mainly used for hemostasis resistance arteries and veins caused by need do cardiac stent and cardiovascular malformation (such as heart
Dirty hemangioma) etc. patients No operation expectant treatment.Simultaneously suitable for coronary disease and angina pectoris, heart left anterior fascicular block,
The various stagnation of blood stasis heart arteries and veins such as bundle-branch block, heart valve incompetence, hyperlipidemia, atrioventricular hypertrophy is extensive before the heart right side
Multiple treatment, improves the blood vessel age.By clinical more than 500 cases, above-mentioned different types of illness is treated with the present invention, effective percentage reaches
To 96%, cure rate reaches 83%, and through follow-up, recurrence rate is very low.
Specific implementation mode
Hereinafter, embodiments of the present invention will be described.
It is an aspect of the invention to provide a kind of Chinese medicine composition for treating angiocardiopathy, including following weight
The Chinese medicine of proportioning：50-70 parts of leech, 100-300 parts of Radix Salviae Miltiorrhizae, 80-150 parts of safflower, 5-10 parts of borneol, 20-60 parts of curcuma zedoary, turmeric
30-60 parts.
Preferably, Chinese medicine composition of the present invention includes the Chinese medicine of following weight proportion：50-60 parts of leech, Radix Salviae Miltiorrhizae
150-250 parts, 90-120 parts of safflower, 5-8 parts of borneol, 20-50 parts of curcuma zedoary, 30-50 parts of turmeric.
Term " leech ", chemical composition mainly contains protein, fresh leech contains hirudin, also contains histamine sample object
Matter and antithrombotic etc..Pharmacological action：There is anticoagulation, improve microcirculation, Robust speaker feature.
Term " Radix Salviae Miltiorrhizae ", chemical composition mainly contain liposoluble constituent and water soluble ingredient, and liposoluble constituent includes Radix Salviae Miltiorrhizae
Ketone I, Tanshinone I I, Tanshinone II B, Tanshinone I II, Cryptotanshinone, hydroxyl tanshinone etc.；Water soluble ingredient mainly contains Radix Salviae Miltiorrhizae
Element, saivianic acid A, second, third, protocatechuic acid etc..Pharmacological action：1. coronary artery can be expanded, increase coronary blood flow, improves cardiac muscle and lack
Blood promotes the recovery of myocardial ischemia or damage；Reduce the range of myocardial infarction；2. hypoxia-bearing capability can be improved, to hypoxic cardiac muscle
There is protective effect；3. microcirculation can be improved, promote velocity of blood flow；4. also have calmness, analgesia, anti-inflammatory, antibacterial, antiallergy, decompression,
Antithrombotic, anti-hepatic fibrosis, anti-ulcer effect；5. having the function of improving renal function, protection Ischemic kieney injury.Clinically
Coronary heart disease, children's acute infectivity toxic myocarditis, early stage ischemia apoplexy, chronic insufficiency etc. can be treated.
Term " safflower ", chemical composition mainly contain carthamone, neocarthamin, carthamic acid, carthamin yellow and Huang
Pigment；Separately contain safflower oil, oil includes palmitic acid, myristic acid, lauric acid, stearic acid, arachidic acid, oleic acid etc..Pharmacology is made
With：1. there is slight excited heart, increases coronary flow and cardiac muscle nutritional blood flow and fight arrhythmia cordis；2. decoction, water
Extract carthamin yellow etc. can expand peripheral vessels, reduce blood pressure；3. carthamic acid can significantly improve hypoxia-bearing capability, weary to ischemic
Oxygen encephalopathy has protective effect；4. decoction has excitation to uterus and intestinal smooth muscle；5. carthamin yellow Central nervous system
System has analgesia, calmness and anticonvulsant action；6. safflower alcohol extract and water extract have anti-inflammatory effect；7. carthamin yellow has immune suppression
It makes and uses.
Term " borneol ", chemical composition mainly contain borneol, isoborneol, camphor；In the resin and volatile oil of kapur
Containing there are many ter penoids；In addition to borneol, still contain sequiterpenes constituents and the olives such as Humuleno, beta-elemene, carypohyllene
The triterpenes components such as acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, erythrodiol.Pharmacological action：1.
There are antibacterial, anti-inflammatory effect, synthetic borneol identical with the bacteriostasis of natural borneol；2. borneol, isoborneol have antibacterial action, and
Rat egg white toes swelling can be significantly inhibited, isoborneol also has inhibiting effect to croton oil auricle edema；3. borneol can be made
For antifertility drug application；4. borneol and isoborneol can extend the hypoxia endurance time of mouse.
Term " curcuma zedoary ", chemical composition are mainly volatile oil ingredient；Wherein RADIX CURCUMAE contain α-firpene, camphor,
1.8-eucalyptols, borneol, rcumenol, isocurcumenol etc..Guangxi zedoary contain α-firpene, β-firpene, limonene, borneol,
Camphor, eugenol, zingiberene, rcumenol, curzerenone, fragrant zingiberone, turmerone, anhydrocurcolone etc..Pharmacological action：1. curcuma zedoary volatilizees
Oil direct destruction existing to a variety of cancer cells, but can by immune system be specific immunity enhancing by obtain significantly exempt from
Epidemic disease protective effect, to have antitumaous effect；2. Curcuma wenyujin volatile oil can inhibit the growth of various pathogens, oil of zedoary turmeric to have obviously
Anti-gastric-ulcer effect；3. Aqueous extracts can inhibit platelet aggregation；4. curcuma zedoary water extracting alcohol liquid has inhibition to internal thrombosis
Effect；5. curcuma zedoary has direct deactivation to Respiratory Syncytial Virus(RSV)；6. oil of zedoary turmeric plays the role of apparent liver protection and Robust speaker feature.
Term " turmeric ", chemical composition mainly contain volatile oil, in oil main component be turmerone, zingiberene, phellandrene,
Borneol etc..Still contain curcumin, Demethoxycurcumin etc..Pharmacological action：1. having anti-inflammatory, antibacterial, antitumor, anti-gastric-ulcer, profit
Courage acts on；2. having reducing blood lipid, blood pressure lowering, Robust speaker feature, anticoagulation and inhibiting platelet aggregation；3. protecting stomach lining, protection
Liver cell；4. can be clinically used for the unbearably painful heart, gastritis, cholangitis, wind-cold-dampness arthralgia, hyperlipidemia etc..
The compatibility meaning of the full side of the present invention is：
We lead all cards all because mechanism of qi blocks, and stasis blocking heart arteries and veins is with the passing of time caused.Side's Radix Salviae Miltiorrhizae, safflower promoting blood circulation, removing blood stasis and relieving pain,
For monarch drug in a prescription；Leech blood-breaking promoting menstruation, by stagnation resolvation lump in the abdomen, curcuma zedoary, turmeric blood-breaking are inducing meastruation to relieve menalgia, are altogether ministerial drug；The above five kinds of Chinese medicine closes
With unimpeded QI stored in the thorax and gas row then blood can be made；Borneol inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain are adjuvant.Full side is taken a broad view of,
Can blood-breaking point the stasis of blood and promoting the circulation of qi divide stagnant, make broken stasis of blood and dredging collateral, the smooth then blood of gas.
As one embodiment of the present invention, the Chinese medicine composition can be tablet, dispersible tablet, powder or capsule
Agent.Preferably, the Chinese medicine composition is capsule.
It is another aspect of the invention to provide it is a kind of for treat angiocardiopathy Chinese medicine composition preparation method,
Wherein, the method includes：Step (1) carries out high-temperature sterilization to leech, Radix Salviae Miltiorrhizae, safflower, borneol, curcuma zedoary, turmeric；And step
(2) it weighs in proportion in step (1) by the Chinese medicine of disinfection, is ground into fine powder, cross 800 mesh sieve, be packed into No. 0 capsule.
Preferably, the ratio in preparation method of the present invention is：It is 50-70 parts of leech, 100-300 parts of Radix Salviae Miltiorrhizae, red
80-150 parts of flower, 5-10 parts of borneol, 20-60 parts of curcuma zedoary, 30-60 parts of turmeric.
It is highly preferred that the ratio in preparation method of the present invention is：50-60 parts of leech, 150-250 parts of Radix Salviae Miltiorrhizae,
90-120 parts of safflower, 5-8 parts of borneol, 20-50 parts of curcuma zedoary, 30-50 parts of turmeric.
Another aspect of the present invention is to provide above-mentioned Chinese medicine composition in the drug for preparing treatment angiocardiopathy
Using.
Preferably, it is described treatment angiocardiopathy include hemostasis resistance arteries and veins caused by need do cardiac stent and cardiovascular malformation
No operation expectant treatment and coronary disease and angina pectoris, heart left anterior fascicular block, the heart of (such as cardiac blood tuberculation) patient
It is dirty it is right before bundle-branch block, heart valve incompetence, hyperlipidemia, atrioventricular hypertrophy stagnation of blood stasis heart arteries and veins resume treatment
One or more of.
The invention will now be further described with reference to specific embodiments, and the advantages and features of the present invention will be with description more
It is clear.But examples are merely exemplary for these, and it is not intended to limit the scope of the present invention in any way.Those skilled in the art
It should be understood that can be carried out without departing from the spirit and scope of the invention to the details and form of technical solution of the present invention
Modifications or substitutions, but these modifications and replacement are each fallen in protection scope of the present invention.
To keep the present invention easier to understand with reference to specific embodiments the present invention is further explained.It is of the present invention
Experimental method if without specified otherwise be conventional method；The biomaterial, if without specified otherwise, it can be from business way
Diameter obtains.
Embodiment 1
1. preparing Chinese medicine composition of the present invention
(1) high-temperature sterilization is carried out to Radix Salviae Miltiorrhizae, safflower, leech, borneol, turmeric, curcuma zedoary；
(2) it weighs in the following proportions in step (1) by the Chinese medicine of disinfection：Leech 0.6g, Radix Salviae Miltiorrhizae 2.0g, safflower
1.5g, borneol 0.06g, curcuma zedoary 0.2g, turmeric 0.3g；
(3) it is ground into fine powder, 800 mesh sieve is crossed, is packed into No. 0 capsule.
2. Chinese medicine composition specification of the present invention：Every weighs about 0.49g
Usage and dosage：Oral one time 1-4,3 times a day, one after each meal.
Taboo：Gastrointestinal ulceration, internal organs organ bleeding, cerebral hemorrhage patient disabling.
Case 1
Patient Yao so-and-so, man, 43 years old, Hebei province Xushui County dragonization villager occurred uncomfortable in chest, shortness of breath, weary in May, 2011
Power, palpitaition, tired postemphasis go to the first central hospital of Baoding medical.Electrocardiogram shows that cardiac arrhythmia, Color Sonography are shown：
It is cardiovascular blockage, cardiovascular malformation, plump with hemangioma, each valve.Auscultation：Five cardiac auscultation area valvular inadequacys.
After the careful medical specialist consultation of doctors, replys patient and need to do three cardiac stents, but it is uncomfortable due to cardiac blood tuberculation
Cardiac stent is done in conjunction, it is proposed that goes home to recuperate.The patient takes 1 drug of embodiment and does not take other drugs again, and after half a year, returning should
The check of heart internal medicine in hospital director Zhang is passed through by hospital, and inspection result is that therapeutic effect is favourable, and symptom is obviously improved；Medication
After 1 year, auscultation is normal, does not recur so far.
Embodiment 2
1. preparing Chinese medicine composition of the present invention
(1) high-temperature sterilization is carried out to Radix Salviae Miltiorrhizae, safflower, leech, borneol, turmeric, curcuma zedoary；
(2) it weighs in the following proportions in step (1) by the Chinese medicine of disinfection：Leech 0.6g, Radix Salviae Miltiorrhizae 2.0g, safflower
1.0g, borneol 0.06g, curcuma zedoary 0.5g, turmeric 0.5g；
(3) it is ground into fine powder, 800 mesh sieve is crossed, is packed into No. 0 capsule.
2. Chinese medicine composition specification of the present invention：Every weighs about 0.49g
Usage and dosage：Oral one time 1-4,3 times a day, one after each meal.
Taboo：Gastrointestinal ulceration, internal organs organ bleeding, cerebral hemorrhage patient disabling.
Case 2
Patient Yang, female, 56 years old, the public villager in Hebei province Xushui County north suffered from coronary disease and angina pectoris, in year in 2010
The Beijing Di Qu 301 Hospital sees a doctor, and Cardiological expert advice patient goes to two cardiac stents, and medical expense is up to 80,000 yuan.It should
Patient takes 2 drug of embodiment and does not take other drugs, the check of 50 Tian Houqugai hospitals, the heart internal medicine in hospital expert diagnosis again
As a result it is that therapeutic effect is good, it is proposed that continue to use the conservative medication.The patient continues after taking the present embodiment drug, listens
It examines normal, does not recur so far.
Embodiment 3
1. preparing Chinese medicine composition of the present invention
(1) high-temperature sterilization is carried out to Radix Salviae Miltiorrhizae, safflower, leech, borneol, turmeric, curcuma zedoary；
(2) it weighs in the following proportions in step (1) by the Chinese medicine of disinfection：Leech 0.6g, Radix Salviae Miltiorrhizae 2.0g, safflower
1.0g, borneol 0.06g, curcuma zedoary 0.5g, turmeric 0.5g；
(3) it is ground into fine powder, 800 mesh sieve is crossed, is packed into No. 0 capsule.
2. Chinese medicine composition specification of the present invention：Every weighs about 0.49g
Usage and dosage：Oral one time 1-4,3 times a day, one after each meal.
Taboo：Gastrointestinal ulceration, internal organs organ bleeding, cerebral hemorrhage patient disabling.
Case 3
Patient Zhang, man, 56 years old, the public villager in Hebei province Xushui County north, in March, 2012 in this county county hospital inspection
Go out and suffer from heart left anterior fascicular block, symptom is uncomfortable in chest, shortness of breath, tired postemphasis.The patient takes 3 drug of embodiment simultaneously
It does not take other drugs again, the hospital is gone to check after two wheat harvesting periods, inspection result is normal ECG, and Color Sonography is normal, until
The present does not recur.
The complication such as the postoperative cardiac foreign matter obstruction of cardiovascular stents operation it is very risky, and average family faces
It is also powerlessly undertaken when the high cost of cardiovascular stents.The Chinese medicine composition of the present invention, meets cardiac stent, heart in treatment
Vascular malformation and when inoperable disease, good surgical result can be reached, significantly reduce the disease of heart patient
Ailing bitter and financial burden.
Chinese medicine composition provided by the present invention can improve systemic blood circulation, dissipating blood stasis with potent drugs, Xuan Tong in the shorter time
Heart arteries and veins, regulating qi-flowing for relieving pain, inducing resuscitation of having one's ideas straightened out improve the blood vessel age.Different type can be treated with Chinese medicine composition provided by the present invention
Cardiovascular disorder, including hemostasis resistance arteries and veins caused by need be cardiac stent and cardiovascular malformation (such as cardiac blood tuberculation) patient
No operation expectant treatment and coronary disease and angina pectoris, heart left anterior fascicular block, the heart right side before bundle-branch block, the heart
The various stagnation of blood stasis heart arteries and veins such as dirty valvular inadequacy, hyperlipidemia, atrioventricular hypertrophy resume treatment.With provided by the present invention
The above-mentioned different types of illness of traditional Chinese medicine composition for treating, in clinical more than 500 cases, effective percentage reaches 96%, and cure rate reaches
83%, through follow-up, recurrence rate is very low.
The above is only the preferred embodiment of the present invention, not does limitation in any form to the present invention, though
So the present invention is disclosed above with preferred embodiment, and however, it is not intended to limit the invention, any technology people for being familiar with this profession
Member, in the range of not departing from technical solution of the present invention, when the technology contents using the disclosure above make a little change or repair
Decorations are the equivalent embodiment of equivalent variations, as long as being the content without departing from technical solution of the present invention, technology according to the present invention is real
Any simple modification, equivalent change and modification made by confrontation above example still fall within the range of technical solution of the present invention
It is interior.
Claims (9)
1. a kind of Chinese medicine composition for treating angiocardiopathy includes the substance of following weight proportion：50-70 parts of leech,
100-300 parts of Radix Salviae Miltiorrhizae, 80-150 parts of safflower, 5-10 parts of borneol, 20-60 parts of curcuma zedoary, 30-60 parts of turmeric.
2. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition includes following weight proportion
Substance：50-60 parts of leech, 150-250 parts of Radix Salviae Miltiorrhizae, 90-120 parts of safflower, 5-8 parts of borneol, 20-50 parts of curcuma zedoary, turmeric 30-50
Part.
3. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition is tablet, dispersible tablet, dissipates
Agent or capsule.
4. Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition is capsule.
5. a kind of preparation method for treating the Chinese medicine composition of angiocardiopathy, which is characterized in that the method includes：Step
Suddenly (1) carries out high-temperature sterilization to leech, Radix Salviae Miltiorrhizae, safflower, borneol, curcuma zedoary, turmeric；And step (2) is weighed in proportion in step
(1) by the Chinese medicine of disinfection in, it is ground into fine powder, 800 mesh sieve is crossed, is packed into No. 0 capsule.
6. preparation method according to claim 5, which is characterized in that the ratio is：50-70 parts of leech, Radix Salviae Miltiorrhizae 100-
300 parts, 80-150 parts of safflower, 5-10 parts of borneol, 20-60 parts of curcuma zedoary, 30-60 parts of turmeric.
7. preparation method according to claim 5, which is characterized in that the ratio is：50-60 parts of leech, Radix Salviae Miltiorrhizae 150-
250 parts, 90-120 parts of safflower, 5-8 parts of borneol, 20-50 parts of curcuma zedoary, 30-50 parts of turmeric.
8. according to claim 1-4 any one of them Chinese medicine composition answering in the drug for preparing treatment angiocardiopathy
With.
9. according to claim 8 any one of them application, wherein the treatment angiocardiopathy includes caused by hemostasis resistance arteries and veins
The No operation expectant treatment and the coronary heart disease heart for needing to do cardiac stent and cardiovascular malformation (such as cardiac blood tuberculation) patient twist
Bitterly, bundle-branch block, heart valve incompetence, hyperlipidemia, chamber fertilizer before heart left anterior fascicular block, the heart right side
Big stagnation of blood stasis heart arteries and veins one or more of resumes treatment.
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| US11602519B1 (en) | 2021-09-02 | 2023-03-14 | King Faisal University | Method for preventing myocardial infarction using eucalyptol |
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| US11602519B1 (en) | 2021-09-02 | 2023-03-14 | King Faisal University | Method for preventing myocardial infarction using eucalyptol |
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Application publication date: 20180810 |