CN109394866A - A kind of necrosis removing and granulation promoting plaster and preparation method thereof - Google Patents
A kind of necrosis removing and granulation promoting plaster and preparation method thereof Download PDFInfo
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- CN109394866A CN109394866A CN201811594053.5A CN201811594053A CN109394866A CN 109394866 A CN109394866 A CN 109394866A CN 201811594053 A CN201811594053 A CN 201811594053A CN 109394866 A CN109394866 A CN 109394866A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Abstract
A kind of necrosis removing and granulation promoting plaster of the present invention, according to preparation method of the present invention by rheum officinale, garden burnet, pheretima, beeswax, erythromycin ophthalmic ointment, diethylstilbestrol is configured to thick paste according to a certain percentage.The present invention has resistance infection strong the postoperative infection surface of a wound not recovered for a long time, without obvious local stimulation and allergic reaction, without apparent toxic side effect.Granulation tissue growth can promote for infective wound surface, do not form a scab after use, do not deepen the surface of a wound, wound healing is fast, and is not required to make skin graft.This myogenic cream production and easy to use, materials are convenient, are suitable for situation of all-level hospitals and family uses, have extensive social benefit.
Description
Technical field
The invention belongs to pharmaceutical technology field, it is related to a kind of necrosis removing and granulation promoting plaster and preparation method thereof.
Background technique
At present clinically, the method that dressing change in surgical department is generally used for infective wound surface gradually makes its healing.But in clinic
There are some patients, slowly (time is more than January) even forms Chronic Sinus through dressing change in surgical department wound healing, caused to patient very big
Psychology, physiology and financial burden, or even thus lead to medical tangle, and all damage to doctor and patient.
Summary of the invention
In order to overcome existing technical deficiency, the present invention provides a kind of necrosis removing and granulation promoting plaster and preparation method thereof.The present invention couple
Including diseases and surgical wound surfaces such as operating rear wound infection disunion, III ° of burn and scald wound, diabetes chronic ulcer, pressure sores
Long-time disunion (time is more than January) and chronic ulcer have significant curative effect after dressing.In order to realize foregoing invention mesh
, the present invention the following technical schemes are provided:
A kind of necrosis removing and granulation promoting plaster is formulated according to following weight ratio: 20-40 parts of rheum officinale, 15-30 parts of garden burnet, and pheretima 15-
30 parts, 2-10 parts of beeswax, 40-60 parts of erythromycin ophthalmic ointment, 0.03-0.06 parts of diethylstilbestrol.
Preferably, a kind of necrosis removing and granulation promoting plaster is formulated according to following weight ratio: 30 parts of rheum officinale, 20 parts of garden burnet, and pheretima 20
Part, 5 parts of beeswax, 50 parts of erythromycin ophthalmic ointment, 0.04 part of diethylstilbestrol.
A kind of preparation method of above-mentioned necrosis removing and granulation promoting plaster, comprising the following steps:
Step 1: by 20-40 parts of rheum officinale, 15-30 parts of garden burnet, 15-30 parts of pheretima, being boiled into decoction, then decoction is condensed into leaching
Cream is added beeswax 2-10 parts, is prepared into thick paste；
Step 2: taking above-mentioned thick paste, by 0.03-0.06 parts of grind into powder of diaethyl stilbestroli tablet, pour into the dressing disinfected
Cylinder will squeeze into completely dressing cylinder under 40-60 parts of aseptic conditions of erythromycin ophthalmic ointment, stir evenly under sterile, obtain the present invention and go
Necrotic tissue and promoting muscle growing cream.
Application method of the invention: when using necrosis removing and granulation promoting plaster for the first time, preparing two sterile spatulas, wound is used double
After oxygen water and salt water are rinsed well, necrosis removing and granulation promoting plaster is uniformly applied to wound with sterile spatula by sterile auxiliary material wiped clean
On, ointment thickness control is in 1 ㎜, aseptic dressing wrapping, suffering limb braking.Second when smearing with sterile spatula by the life of the surface of a wound
Flesh cream gently scraped clean, then necrosis removing and granulation promoting plaster is smeared with sterile spatula, it replaces within every 6 hours.
Composition pharmacology and Analysis on action mechanism in the present invention are as follows in above scheme:
Rheum officinale: purging fire for removing toxin, promoting blood circulation；It is rheum officinale Great Cold, nontoxic.Record rheum officinale is logical in " Japan hanako materia medica " declares all
Gas adjusts blood vessels and applies-cut boil carbuncle poison.Record rheum officinale treating chilblain skin is tattered in " precious mirror of hygiene ", unbearably painful, characters function
Definitely, quick.Modern medicine study proves that rheum officinale has anti-infectious function, resisting pathogenic microbes effect, anti-inflammatory, antipyretic work
With immunoregulation effect, anti-aging antioxidation and anastalsis.
Garden burnet: " detailed outline ": garden burnet, except lower burnt heat, hemostasis, the tip then can promoting circulation of blood.Yang Shiying cloud: all sore pain persons add garden burnet.
" book on Chinese herbal medicine is looked for the truth ": garden burnet, the main convergence of property can drop clearly and inducing astrigency, then do not consider it clearly and cross and let out, it is puckery also do not consider itself or it is stagnant, it is real
The antipyretic hemostatic of power." Bie Lu " meaning stops purulence blood, and it is all the function of this cool blood of relieving inflammation or internal heat that malignant sore herpes simplex, which can make metal-inflicted wound cream,." book on Chinese herbal medicine
Justice ": garden burnet bitter cold is the special agent of cool blood.It relieves pain except meat is disliked, all ulcer says it in addition, and blood-head fire is contained, then dislikes meat bitterly, ground more
Elm clearing heat and cooling blood, therefore relieve pain, and can be except evil meat." Bie Lu ": only purulence blood, all impotences, malignant sore can make metal-inflicted wound cream." drugization justice ": solution
All heat toxin carbuncles.Modern medicine study proves: garden burnet have blood-stanching and blood-cooling, clearing heat and detoxicating, astringing to arrest diarrhea and inhibit it is a variety of cause a disease it is micro-
Biology and tumour effect, can treat haematemesis, bloody flux, burn the big bleeding of wound, eczema, upper gastrointestinal bleeding, canker, hematochezia,
The diseases such as metrorrhagia and metrostaxis, Tuberculous purulence ulcer and chronic osteomyelitis.
Pheretima: Compendium of Material Medica records pheretima treatment scrofula and festers the person that flows string: pheretima can treat various diseases, the function of pheretima
Effect: heat-clearing relieve the wind syndrome, is relievingd asthma, dredging collateral, diuresis.Modern pharmacological research proves, pheretima truly have it is antipyretic, calm, anticonvulsion, relieving asthma, drop
The multiple pharmacological effects such as pressure.Pheretima extracting solution has good anticoagulation in vitro, can make the clotting time of blood, when fibrin ferment
Between, prothrombin time significantly extends；Blood viscosity can be reduced；
Beeswax: patent medicine excipient, inducing astrigency, sore, myogenic, analgesic.
Diethylstilbestrol: diethylstilbestrol is artificial synthesized nonsteroidal estrogen substance, can be generated and natural estradiol phase
Same all pharmacology and therapeutic effect.Modern medicine proves that diethylstilbestrol can improve skin and musculature blood circulation, promotees
It is grown into granulation tissue, accelerates postmenopausal women and the elderly's wound healing, accelerate chronic ulcer wound healing.
Erythromycin ophthalmic ointment: have quite by force to gram positive bacteria, such as staphylococcus, micrococcus scarlatinae, viridans streptococci
Big inhibiting effect.In addition, having inhibiting effect to mycoplasma, Richettsia and a small number of mycobacterias and Amoeba.
Solution of the invention is the pathogenesis of such disease and recognizing for principle of reatment based on traditional Chinese medicine pair
Know, with reference to modern medical theory, with it is clearing heat and detoxicating, remove necrosis and promote granulation, hold back burst more ulcer, eliminate local infection stove, improve microcirculation etc.
Major measure plays the respective advantage of Chinese and Western medicine.The present invention pass through long-term clinical practice, summarize more than 150 cases on the basis of
(treatment patient chart one, table two) is formed through scientific composition.
Wound healing standard: 1. body temperature are normal, and wound is without red, swollen, hot, pain；2. chemically examining inflammatory parameters CRP, ESR, WBC just
Often；3. wound skin healing is good, dry, no secretion.
The effective standard of wound: 1. body temperature are normal, and wound contraction, which perhaps shoals, red, swollen, hot, pain any one or equal
Normally；2. chemical examination inflammatory parameters CRP, ESR, WBC mono- is abnormal；3. wound is ruddy, a small amount of 4. wound of secretion was with this medicine 4 weeks
It gradually heals afterwards.
The effective standard of wound: between wound healing and effective standard.
Therapeutic effect of the invention is described below with reference to case:
Certain male of case 1,43 years old, foot injured by a crashing object with phalangeal fracture postoperative January, and for instep soft tissue defects with infection, defect is big
Small about 4 ㎝, part tendon exposed, edge of wound musculature color are greyish white.It is smeared this hair cream medicine three days, is improved, fully recovered within 4 weeks, nothing
Skin allergy symptom occurs.
Certain male of case 2,67 years old, diabetes 1 year.There are a 4cm open sore part, wound surrounding skin in a left side seen in checking with rear outside
Edge blacks, and wound is deep, and purulence coating colour is yellow, stiff.Diagnosis diabetes simultaneously infect.It fullys recover from an illness within 4 weeks through necrosis removing and granulation promoting plaster external application of the present invention
More, no skin allergy symptom occurs, so far without recurrence.
Certain female of case 3,50 years old, after fracture of calcaneus internal fixation more than March, notch chronic ulcer was formed, through changing
Medicine wound healing is slow, and outpatients mental state burden is larger, goes to a doctor later in vain through certain hospital's western medical treatment.After checking finding about calcaneum
Outside 4cm operative incision splits, and purulence tongue fur is formed.Diagnose postoperative wound infection.Application drug January of the present invention, wound healing, without multiple
Hair, no skin allergy symptom occur.
Patient's number 150 are observed altogether, total effective rate 96%
A kind of necrosis removing and granulation promoting plaster of the present invention has resistance infection strong the postoperative infection surface of a wound not recovered for a long time, without obvious office
Portion's stimulation and allergic reaction, without apparent toxic side effect.Granulation tissue growth can promote for infective wound surface, do not tied after use
Scab does not deepen the surface of a wound, and wound healing is fast, and is not required to make skin graft.This myogenic cream production and easy to use, materials are convenient, are suitable for each
Grade hospital and family use, and have extensive social benefit.
Specific embodiment
The present invention is described further with reference to embodiments, but the invention is not limited to embodiments.
Embodiment 1
Step 1: taking 30 grams of rheum officinale, 20 grams of garden burnet, 20 grams of pheretima, be boiled into decoction, then decoction is condensed into medicinal extract, bee is added
5 grams of wax, it is prepared into thick paste；
Step 2: above-mentioned thick paste is taken, by 4 milligrams of grind into powder of diaethyl stilbestroli tablet, pours into the dressing cylinder disinfected, it will be red
Dressing cylinder is squeezed into completely under 50 grams of aseptic conditions of mycin eye ointment, is stirred evenly under sterile, is obtained necrosis removing and granulation promoting plaster of the present invention.
Embodiment 2
Step 1: taking 20 grams of rheum officinale, 18 grams of garden burnet, 15 grams of pheretima, be boiled into decoction, then decoction is condensed into medicinal extract, bee is added
3 grams of wax, it is prepared into thick paste；
Step 2: above-mentioned thick paste is taken, by 3 milligrams of grind into powder of diaethyl stilbestroli tablet, pours into the dressing cylinder disinfected, it will be red
Dressing cylinder is squeezed into completely under 45 grams of aseptic conditions of mycin eye ointment, is stirred evenly under sterile, is obtained necrosis removing and granulation promoting plaster of the present invention.
Above-described embodiment, only presently preferred embodiments of the present invention, is not intended to limit the invention practical range, therefore all with this
The equivalence changes that content described in invention claim is done should all be included within scope of the invention as claimed.
Claims (3)
1. a kind of necrosis removing and granulation promoting plaster, which is characterized in that be formulated according to following weight ratio: 20-40 parts of rheum officinale, garden burnet 15-30
Part, 15-30 parts of pheretima, 2-10 parts of beeswax, 40-60 parts of erythromycin ophthalmic ointment, 0.03-0.06 parts of diethylstilbestrol.
2. a kind of necrosis removing and granulation promoting plaster as described in claim 1, which is characterized in that be formulated according to following weight ratio: rheum officinale
30 parts, 20 parts of garden burnet, 20 parts of pheretima, 5 parts of beeswax, 50 parts of erythromycin ophthalmic ointment, 0.04 part of diethylstilbestrol.
3. a kind of preparation method of necrosis removing and granulation promoting plaster as described in claim 1, comprising the following steps:
Step 1: by 20-40 parts of rheum officinale, 15-30 parts of garden burnet, 15-30 parts of pheretima, it is boiled into decoction, then decoction is condensed into medicinal extract,
5 parts of beeswax are added, thick paste is prepared into；
Step 2: above-mentioned thick paste is taken, by 0.03-0.06 parts of grind into powder of diaethyl stilbestroli tablet, pours into the dressing cylinder disinfected, it will
Dressing cylinder is squeezed into completely under 40-60 parts of aseptic conditions of erythromycin ophthalmic ointment, is stirred evenly under sterile, is obtained the present invention and remove necrosis and promote granulation
Cream.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811594053.5A CN109394866B (en) | 2018-12-25 | 2018-12-25 | Paste for removing necrotic tissue and promoting tissue regeneration and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811594053.5A CN109394866B (en) | 2018-12-25 | 2018-12-25 | Paste for removing necrotic tissue and promoting tissue regeneration and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109394866A true CN109394866A (en) | 2019-03-01 |
| CN109394866B CN109394866B (en) | 2021-04-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811594053.5A Active CN109394866B (en) | 2018-12-25 | 2018-12-25 | Paste for removing necrotic tissue and promoting tissue regeneration and preparation method thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927293A (en) * | 2006-09-06 | 2007-03-14 | 北京润德康医药技术有限公司 | Chinese medicine composition for treating skin burn and scald |
-
2018
- 2018-12-25 CN CN201811594053.5A patent/CN109394866B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1927293A (en) * | 2006-09-06 | 2007-03-14 | 北京润德康医药技术有限公司 | Chinese medicine composition for treating skin burn and scald |
Non-Patent Citations (2)
| Title |
|---|
| 徐志军: "乙烯雌酚治疗褥疮", 《辽宁中级医刊》 * |
| 章梅等: "地龙提取物对大鼠深Ò度烫伤创面愈合的影响", 《中药材》 * |
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