CN109966364A

CN109966364A - A kind of Chinese medicine composition and preparation method thereof for treating skin trauma

Info

Publication number: CN109966364A
Application number: CN201910231727.3A
Authority: CN
Inventors: 朱永发
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-03-26
Filing date: 2019-03-26
Publication date: 2019-07-05

Abstract

The invention discloses a kind of Chinese medicine compositions and preparation method thereof for treating skin trauma, are made of following raw material: polygonum cuspidate, charred RADIX SANGUISORBAE, Cortex Phellodendri charcoal, Radix Angelicae Sinensis, olibanum, myrrh, rheum officinale, safflower, sunset abelmoschus flower, Asian puccoon, folium callicarpae pedunculatae, Akebia Fruit, catechu, acute turpinia leaf, cymose buckwheat rhizome, tuniclike psammosilene root, pearl powder, cape jasmine, Paris polyphylla, lamiophlomis rotata, talcum, cuttlebone, semen coicis, cordate houttuynia, borneol, honey, sesame oil.The effect of present invention has rapid analgesic hemostatic, removing pattogenic heat from the blood and toxic material from the body, antibacterial sterilizing, anti-inflammation detumescence, apocenosis are dispelled corruption, blood activating and promoting tissue regeneration and refreshment and tranquilization, it can be used for treating burn and scald, fall the skin traumas such as scratch, skin ulcer, mucosa injury；Using+50% ethyl alcohol extraction of enzyme deactivation+spray drying, the necessary bioactive substance dissolution that skin trauma quickly heals may advantageously facilitate.The present invention is quick, curative effect is high, short treating period, has no toxic side effect, is easy to use.

Description

A kind of Chinese medicine composition and preparation method thereof for treating skin trauma

Technical field

The present invention relates to technical field of traditional Chinese medicines, the Chinese medicine composition of specifically a kind for the treatment of skin trauma and its preparation side Method.

Background technique

Skin trauma such as burn and scald, scratch, skin ulcer, mucosa injury, surgical incision are the common of surgical clinical Disease.

Burn and scald is the skin of thermal energy infiltration people a kind of, and skin surface or table undertissue is caused damages in various degree or downright bad The illness of property.Burn and scald once occurs for people, brings insufferable pain to people immediately, while the later period of burn and scald restores, It is easiest to raw scar cicatrization.When burn and scald just occurs, serious patient is mostly in great pain, or even can not cooperate the treatment of doctor, Cause treatment to delay, and delay the crucial opportunity for the treatment of, at the same time, the reconvalescent for the treatment of again need dressing repeatedly, and also It bears the pain, therefore should safely and effectively be relieved pain through the basis for the treatment of burn and scald；Treat the process of burn and scald, inhibit and The virus and infect also important aspect that wound is bred are eliminated, the pyogenic infection of skin wound, motherland doctor are otherwise easily caused Think that pyogenic infection is the resistance of exogenous disease cult poison between skin and flesh, so that battalion Yu Buhe, channels and collaterals barrier, qi and blood stagnation.Clinically Show themselves in that red and swollen heat pain at skin injury, sore has met personally purulent secretion, and Ju Bu inflammation is crimson swollen and spreads around, with hair The symptoms such as hot, thirsty, vexed；The interpretation of the cause, onset and process of an illness is: malicious heresy pent up resistance between skin and flesh, clinically by it is dialectical take it is clearing heat and detoxicating, Hygroscopic sore is seted forth one's views as treatment, has obtained preferable therapeutic effect.

Skin surface and deep tissues in human body occurs for burn and scald, can be divided into I, II, III degree according to depth is burnt, burn Scald easily causes to mix outside skin surface bacterium infection, body fluid, skin deformation, leaves scar etc., in addition cause high fever, shock, Threat to life, so how to make the healing and art technology of fire victim's fast speed, high quality while effective analgesic The target that personnel pursue always.

Skin wound healing was usually intended to by two stages, first is that inflammatory phase, second is that proliferative phase.Inflammatory reaction is human body By causing to damage a kind of defense reactions occurred caused by scorching stimulants to various when damaging, it is rotten by local organization, Exudation and hyperplasia, the cell for being eliminated with limitation and repelling external virulence factor and dying from a wound, to be established for wound healing Basis.Proliferative phase, relates generally to the reparation and regeneration of epithelial tissue and dense connective tissue, mainly includes re-epithelialization and granulation Tissue generates two stages；Re-epithelialization includes the increment, migration and differentiation three phases of epithelial cell, after epidermis is impaired, is lacked The continuous division growth of the basal cell of the surrounding broken ends of fractured bone at damage, and migrated to the surface of a wound, when newborn epithelial cell is paved with surface of a wound surface Afterwards, thin epidermis is re-formed；After Dermal defect, fibroblast largely secretes collagen, elastin laminin, fiber adhesion egg White and glycosaminoglycan etc., and synthesize a large amount of collagenous fibres, while fibroblast synthesizes collagen, clostridiopetidase A is but constantly Collagen is decomposed, but synthesis at this time is greater than and decomposes, as collagen largely generates and the proliferation of capillary bud, granulation tissue gradually shape At, and constantly filling wound chamber, because lacuna fills up, granulation tissue is mature, and fibroblast therein switchs to fibrocyte, blood capillary Pipe occlusion, disappearance, quantity is reduced, last newborn granulation tissue becomes to lack blood vessel, is faint in color, is hard, mainly by glue The fibrous connective tissue of original composition, scar tissue are formed, wound healing.

Currently, the drug for treating skin trauma in the market mainly has three classes, and first is that: Western medicine preparation；Second is that: Chinese medicine system Agent；Third is that: Chinese and Western medicine composite preparation.Have the following deficiencies: that most of is ointment formulation in clinical use, such vulneraia Drug matrices are not easy to be absorbed by tissue, and the surface of a wound will necessarily be in molten state, are on the one hand easy to cause bacterium infection, on the other hand again The formation for influencing the last layer skin when tissue repair, causes wound healing time to extend, part wound externally applied drug has patient Allergic reaction, leads to obstinate, and the course of disease extends；And since big drug does not have the effect for scar of dispelling, pole after treatment is healed Easy scar influences beautiful.Therefore, a kind of fast and effective, low cost, dispel with sterilizing analgesic, apocenosis corruption, promoting blood circulation are developed Myogenic effect for treat the Chinese materia medica preparation of skin trauma very it is necessary to.

Summary of the invention

The purpose of the present invention is to overcome the deficiency in the prior art, adapts to realistic development, provides a kind of skin trauma for the treatment of Chinese medicine composition.

In order to achieve the above objectives, The technical solution adopted by the invention is as follows:

A kind of Chinese medicine composition for treating skin trauma, including following raw material: Radix Angelicae Sinensis, polygonum cuspidate, charred RADIX SANGUISORBAE, Cortex Phellodendri charcoal, Olibanum, myrrh, rheum officinale, safflower, borneol, honey and sesame oil.

Upper basic technology scheme is carried out preferably, the raw material including following parts by weight: 50~70 parts of polygonum cuspidate, charred RADIX SANGUISORBAE 50~ 70 parts, 50~70 parts of Cortex Phellodendri charcoal, 30~50 parts of Radix Angelicae Sinensis, 30~50 parts of olibanum, 20~40 parts of myrrh, 20~40 parts of rheum officinale, safflower 20~40 parts, 10~20 parts of borneol, 10~20 parts of honey and 80~100 parts of sesame oil.

Upper basic technology scheme preferably, be made of the raw material of following parts by weight: 50~70 parts of polygonum cuspidate, charred RADIX SANGUISORBAE 50 ~70 parts, it is 50~70 parts of Cortex Phellodendri charcoal, 30~50 parts of Radix Angelicae Sinensis, 30~50 parts of olibanum, 20~40 parts of myrrh, 20~40 parts of rheum officinale, red Spend 20~40 parts, 50~70 parts of sunset abelmoschus flower, 30~50 parts of Asian puccoon, 30~50 parts of folium callicarpae pedunculatae, 30~50 parts of Akebia Fruit, catechu 20 ~40 parts, 20~40 parts of acute turpinia leaf, 20~40 parts of cymose buckwheat rhizome, 20~40 parts of tuniclike psammosilene root, 20~40 parts of pearl powder, cape jasmine 20 ~40 parts, 20~40 parts of Paris polyphylla, 20~40 parts of lamiophlomis rotata, 20~40 parts of talcum, 20~40 parts of cuttlebone, semen coicis 20~40 Part, 20~40 parts of cordate houttuynia, 10~20 parts of borneol, 10~20 parts of honey, 80~100 parts of sesame oil.

To upper basic technology scheme carry out preferably, be made of the raw material of following parts by weight: 60 parts of polygonum cuspidate, 60 parts of charred RADIX SANGUISORBAE, 60 parts of Cortex Phellodendri charcoal, 40 parts of Radix Angelicae Sinensis, 40 parts of olibanum, 30 parts of myrrh, 30 parts of rheum officinale, 30 parts of safflower, 60 parts of sunset abelmoschus flower, Asian puccoon 40 Part, 40 parts of folium callicarpae pedunculatae, 40 parts of Akebia Fruit, 30 parts of catechu, 30 parts of acute turpinia leaf, 30 parts of cymose buckwheat rhizome, 30 parts of tuniclike psammosilene root, pearl powder 30 Part, 30 parts of cape jasmine, 30 parts of Paris polyphylla, 30 parts of lamiophlomis rotata, 30 parts of talcum, 30 parts of cuttlebone, 30 parts of semen coicis, 30 parts of cordate houttuynia, ice 15 parts of piece, 15 parts of honey, 90 parts of sesame oil.

A kind of preparation method of above-mentioned Chinese medicine composition for treating skin trauma, includes the following steps:

(1) solid material of the parts by weight is crushed to 300~500 mesh of fine powder, is adjusted with NaAc-HAc buffer solution PH to 5~6 adds appropriate cellulase under the conditions of 45~50 DEG C, and constant temperature digests 20~30min, and 100~110 DEG C go out It is living, it filters at room temperature, obtains filtering powder；

(2) it filters the extraction of 50% alcohol reflux 2~4 hours that powder is added 3~5 times, collects reflux extracting liquid, depressurize dense Contracting, spray drying, obtains mixing powder；

(3) mixing powder is added in the sesame oil of the parts by weight, decocts refining, Oil-temperature control decocts refining 1~2 at 200~220 DEG C Hour, oil temperature is down to 100~120 DEG C, and residual oil separation obtains decocting oil refining agent；

(4) honey of the parts by weight is added and decocts oil refining agent, stirred evenly, natural cooling, drug paste is made.

The present invention also aims to protect the Chinese medicine composition in preparation for treating the application in burn and scald medicine； In preparation for falling the application in the analgesic drug product in scratch, burn and treatment of scald；In preparation for treating skin ulcer, gluing Application in membrane damage drug.

The present invention also aims to a kind of Chinese medicine compositions for treating skin trauma for protecting the above method to prepare to make The application being ready for use in treatment burn and scald medicine.

Compared with prior art, the advantages and positive effects of the present invention are as follows:

Polygonum cuspidate, slight bitter are slightly cold.Return liver, gallbladder, lung channel.Removing dampness through diuresis and removing jaundice, clearing heat and detoxicating, removing blood stasis and acesodyne is relieving cough and reducing sputum.For Jaundice with damp-heat pathogen, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, carbuncle sore tumefacting virus, scald, menostasis , Disorder lump in the abdomen, traumatic injury, cough with lung heat.

Charred RADIX SANGUISORBAE, it is bitter, sour, puckery, it is slightly cold.Return liver, large intestine channel.Cooling blood and hemostasis, removing toxic substances sore.For hematochezia, hemorrhoid blood, blood Dysentery, metrorrhagia and metrostaxis, scald, carbuncle sore tumefacting virus.

Cortex Phellodendri charcoal, it is bitter, it trembles with fear.Return kidney, bladder meridian.Heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment.For damp-heat dysentery, yellow subcutaneous ulcer Urinate red, leukorrhagia pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis Wei cu, hectic fever due to yin labor heat, night sweat, spermatorrhea, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution is grown Negative fall fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.

Radix Angelicae Sinensis, sweet, acrid, warm.Return liver, the heart, the spleen channel.Replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels.It is dizzy for blood deficiency chlorosis Dizzy palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine Blood circulation.For amenorrhea and algomenorrhea, rheumatic arthralgia falls and flutters damage and put in order.

Olibanum, pungent, bitter, temperature.Return heart, liver, the spleen channel.Promoting blood circulation analgesic therapy, detumescence and promoting granulation.For chest impediment and cardialgia, gastral cavity pain, pain Through menostasis, postpartum stasis , abdominal mass and abdominal pain, rheumatic arthralgia, muscle arteries and veins contraction, traumatic injury, carbuncle swells sore.

Myrrh, it is pungent, bitter, it puts down.Return heart, liver, the spleen channel.Scattered stasis pain, detumescence and promoting granulation.For chest impediment and cardialgia, gastral cavity pain, pain Through menostasis, postpartum stasis , abdominal mass and abdominal pain, phoenix arthritis with fixed pain caused by dampness pain, traumatic injury, carbuncle swells sore.

Rheum officinale, it is bitter, it trembles with fear.Returns spleen, stomach, large intestine, liver, pericardium channel.Heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body are logical by the stasis of blood Through removing dampness through diuresis and removing jaundice.It stagnates constipation for real heat, blood-head spits mandrill, hot eyes pharynx swelling, carbuncle swells furunculosis, abdominalgia with intestinal abscess, and blood stasis closed produces Stasis blocking afterwards, traumatic injury, damp-heat dysentery, jaundice and reddish urine, stranguria, oedema；Externally treating burns and scalds.Rheum palmatum (processed with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs blood system heat Poison is used for hot eyes pharynx swelling, gingivitis.Prepared RADIX ET RHIZOMA RHEI rush down exert oneself to delay, purging fire for removing toxin, be used for pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis Hemostasis, has stasis of blood haemorrhage for blood-head.

Safflower, it is acrid in flavour and warm in nature.Converge to heart and liver channels.Blood circulation, removing blood stasis and acesodyne.For menostasis, dysmenorrhea, lochia , Disorder lump in the abdomen ruffian Block, chest impediment and cardialgia, stasis of blood, chest side of body twinge, injury from falling down, the swelling and pain of girdle ulcer.

Sunset abelmoschus flower, it is sweet, cold.Return kidney, bladder meridian.Eliminating dampness and heat, subdhing swelling and detoxicating.Hold back for damp and hot heap soil or fertilizer over and around the roots, stranguria with turbid discharge oedema；Outside Control swollen ulcer drug, scald.

Asian puccoon, it is sweet, salty, it trembles with fear.Converge to heart and liver channels.Clearing heat and cooling blood, promoting blood circulation and detoxication, promoting eruption ecchymose removing.For blood-heat and toxin exuberance, macula Purple black, measles without adequate eruption, sore, eczema, scald.

Folium callicarpae pedunculatae, it is bitter, puckery, it is cool.Return liver, lung, stomach meridian.Cool blood astringing to arrest bleeding dissipates stasis of blood removing toxicity for detumescence.For bleeding from five sense organs or subcutaneous tissue, spit blood, It spits blood, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, pathopyretic ulcer, scald.

Akebia Fruit, it is bitter, it trembles with fear.Return liver, gallbladder, stomach, bladder meridian.Dispersing stagnated hepatoqi, promoting blood circulation and stopping pain, dissipating bind, diuresis.It is coerced for gastral cavity swollen Bitterly, dysmenorrhea menostasis, subcutaneous nodule lump in the abdomen, difficult urination.

Catechu, it is bitter, puckery, it is slightly cold.Return lung, the heart channel of Hang-Shaoyin.Promoting blood circulation and stopping pain, hemostasia and promoting granulation, hygroscopic sore , Cheongju lung resolving sputum.For falling Flutter the pain of injury, traumatic hemorrhage, haematemesis brain blood, sore do not hold back, eczema, wet sore, cough with lung heat.

Acute turpinia leaf, it is bitter, it trembles with fear.Return lung, Liver Channel.It is clearing heat and detoxicating, reducing pharyngeal swelling, promoting blood circulation and stopping pain.For tonsillitis and larynx numbness, throat Swelling and pain, sore swollen toxin, the pain of injury caused by falling and tumbling.

Cymose buckwheat rhizome, it is micro-pungent, puckery, it is cool.It is distributed in lung channel.It is clearing heat and detoxicating, apocenosis dissolving stasis.For lung carbuncle pyemesis, dyspnea and cough due to lung-heat, acute tonsillitis Swelling and pain.

Tuniclike psammosilene root, it is bitter, acrid in flavour and warm in nature；It is slightly poisonous.Return liver warp.Dispelling wind and eliminating dampness, removing blood stasis and acesodyne, removing toxicity for detumescence.For rheumatism numbness Bitterly, stomachache with cool feeling, traumatic injury, traumatic hemorrhage；Boil, snakebite and bugbite are controlled outside.

Pearl powder, it is sweet, salty, it trembles with fear.Converge to heart and liver channels.Calm the nerves arresting convulsion, improving eyesight disappears screen, solves taking poison and growing muscle due, moistening skin and eliminating spot.For shying Throb with fear insomnia, infantile convulsion epilepsy, cataract, sore do not hold back, skin splash.

Cape jasmine, it is bitter, it trembles with fear.Return heart, lung, tri-jiao channel.Purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body；Externally used detumescence analgesic.With In Vexed, jaundice with damp-heat pathogen, the puckery pain of stranguria, blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles；Bruise pain is controlled outside.

Paris polyphylla, it is bitter, it is slightly cold；It is slightly poisonous.Return liver warp.It is clearing heat and detoxicating, swelling and pain relieving, cool liver arresting convulsion.For furunculosis carbuncle swells, pharynx Larynx swelling and pain, snakebite and bugbite, the pain of injury caused by falling and tumbling, convulsion.

Lamiophlomis rotata, it is sweet, bitter, it puts down.Return liver warp.Promoting blood circulation and hemostasis, wind-expelling pain-stopping.For traumatic injury, traumatic hemorrhage, rheumatism numbness Bitterly, grasserie.

Talcum, it is sweet, light, it trembles with fear.Return bladder, lung, stomach meridian.Inducing diuresis for treating strangurtia, clearing away summerheat；External application clearing damp sore.For heat gonorrhea, Urolithiasis, the puckery pain of urine heat, summer-heat and damp polydipsia, damp and hot watery diarrhea；Eczema, wet sore, prickly heat are controlled outside.

Cuttlebone, salty, puckery, temperature.Returns spleen, kidney channel.Astringing to arrest bleeding, relieving leukorrhea by astringents, hyperacidity and pain relief, hygroscopic sore.For spitting Blood mandrill blood, metrorrhagia and metrostaxis hematochezia, emission and spermatorrhea, leukorrhea with reddish discharge, acid regurgitation of having a stomachache；Bleeding due to trauma, eczema wet sore, unhealing ulcer are controlled outside.

Semen coicis, it is sweet, light, it is cool.Returns spleen, stomach, lung channel.Clearing damp and promoting diuresis, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, detoxicating and resolving a mass.With In oedema, tinea pedis, difficult urination, splenasthenic diarrhea, arthritis with fixed pain caused by dampness muscular constricture, pulmonary abscess, acute appendicitis, wart, cancerous swelling.

Cordate houttuynia, it is pungent, it is slightly cold.It is distributed in lung channel.It is clearing heat and detoxicating, the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia.For lung carbuncle pyemesis, phlegm heat panting Cough, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.

Borneol, it is pungent, bitter, it is slightly cold.Return heart, spleen, lung channel.Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.For pyreticosis coma, faint from fear, apoplexy Coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, chest impediment and cardialgia, hot eyes, aphtha, abscess of throat, purulent ear canal.

Honey, sweet and neutral.Return lung, spleen, large intestine channel.Bowl spares is moisturized, and is relieved pain, removing toxic substances；External application myogenic sore.For stomach duct and abdomen void Bitterly, dryness of the lung dry cough, dry constipation of intestines solve Aconitum poisoning of drug；It controls sore outside not hold back, scald.

Sesame oil, sweet in flavor, cold nature is nontoxic, enters meridian of Hand-YANG MING, has the effect of removing toxic substances, myogenic.

The Chinese medicine composition for the treatment of skin trauma provided by the invention is to relieve pain sterilizing, apocenosis is dispelled rotten and blood activating and promoting tissue regeneration as Compatibility purport has rapid analgesic hemostatic, removing pattogenic heat from the blood and toxic material from the body, antibacterial sterilizing, anti-inflammation detumescence, apocenosis are dispelled rotten, blood activating and promoting tissue regeneration and restoring consciouness peace Effect of mind, can be used for treating burn and scald, falls the skin traumas such as scratch, skin ulcer, mucosa injury；Using+50% second of enzyme deactivation Alcohol extracting+spray drying is conducive to such as the less big polysaccharide of inorganic salts, carbohydrate, molecule, tannin, amino acid, protein, has Machine hydrochlorate, alkaloid salt and glucoside etc. are fully dissolved out, and above-mentioned bioactive substance be skin trauma quickly heal must Want element.Compatibility of the present invention is reasonable, medication is superior, and preparation method is with strong points, and local application guides drugs to illness station, quick, curative effect Height short treating period, has no toxic side effect, is easy to use.

Specific embodiment

It elaborates below to specific embodiments of the present invention.

Embodiment 1

A kind of Chinese medicine composition for treating skin trauma, is made of the raw material of following parts by weight: 60 parts of polygonum cuspidate, charred RADIX SANGUISORBAE 60 Part, 60 parts of Cortex Phellodendri charcoal, 40 parts of Radix Angelicae Sinensis, 40 parts of olibanum, 30 parts of myrrh, 30 parts of rheum officinale, 30 parts of safflower, 60 parts of sunset abelmoschus flower, Asian puccoon 40 parts, 40 parts of folium callicarpae pedunculatae, 40 parts of Akebia Fruit, 30 parts of catechu, 30 parts of acute turpinia leaf, 30 parts of cymose buckwheat rhizome, 30 parts of tuniclike psammosilene root, pearl 30 parts of powder, 30 parts of cape jasmine, 30 parts of Paris polyphylla, 30 parts of lamiophlomis rotata, 30 parts of talcum, 30 parts of cuttlebone, 30 parts of semen coicis, cordate houttuynia 30 Part, 15 parts of borneol, 15 parts of honey, 90 parts of sesame oil.

The preparation method of the Chinese medicine composition of above-mentioned treatment skin trauma, includes the following steps:

(1) solid material of the parts by weight is crushed to 400 mesh of fine powder, with NaAc-HAc buffer solution adjust pH to 5.5, appropriate cellulase is added under the conditions of 48 DEG C, and constant temperature digests 25min, and 105 DEG C of inactivations are filtered at room temperature, taken out Filter powder；

(2) it filters the extraction of 50% alcohol reflux 3 hours that powder is added 4 times, collects reflux extracting liquid, be concentrated under reduced pressure, spray Mist is dry, obtains mixing powder；

(3) mixing powder being added in the sesame oil of the parts by weight, decocts refining, Oil-temperature control decocts refining 1.5 hours at 210 DEG C, Oil temperature is down to 110 DEG C, and residual oil separation obtains decocting oil refining agent；

Application method: directly spreading on affected part, is preferred with 1~1.5mm thickness, changes within 1st primary；Hot water must not be contacted at coating And warm water, while avoiding eating raw, cold food object.

Embodiment 2

A kind of Chinese medicine composition for treating skin trauma, is made of the raw material of following parts by weight: 70 parts of polygonum cuspidate, charred RADIX SANGUISORBAE 70 Part, 70 parts of Cortex Phellodendri charcoal, 50 parts of Radix Angelicae Sinensis, 50 parts of olibanum, 40 parts of myrrh, 40 parts of rheum officinale, 40 parts of safflower, 70 parts of sunset abelmoschus flower, Asian puccoon 50 parts, 50 parts of folium callicarpae pedunculatae, 50 parts of Akebia Fruit, 40 parts of catechu, 40 parts of acute turpinia leaf, 40 parts of cymose buckwheat rhizome, 40 parts of tuniclike psammosilene root, pearl 40 parts of powder, 40 parts of cape jasmine, 40 parts of Paris polyphylla, 40 parts of lamiophlomis rotata, 40 parts of talcum, 40 parts of cuttlebone, 40 parts of semen coicis, cordate houttuynia 40 Part, 20 parts of borneol, 20 parts of honey, 100 parts of sesame oil.

(1) solid material of the parts by weight is crushed to 500 mesh of fine powder, adjusts pH to 6 with NaAc-HAc buffer solution, Appropriate cellulase is added under the conditions of 50 DEG C, constant temperature digests 30min, and 110 DEG C of inactivations filter at room temperature, obtains filtering powder End；

(2) it filters the extraction of 50% alcohol reflux 4 hours that powder is added 5 times, collects reflux extracting liquid, be concentrated under reduced pressure, spray Mist is dry, obtains mixing powder；

(3) mixing powder is added in the sesame oil of the parts by weight, decocts refining, Oil-temperature control decocts refining 2 hours, oil at 220 DEG C To 120 DEG C, residual oil separation obtains decocting oil refining agent temperature drop；

Embodiment 3

A kind of Chinese medicine composition for treating skin trauma, is made of the raw material of following parts by weight: 50 parts of polygonum cuspidate, charred RADIX SANGUISORBAE 50 Part, 50 parts of Cortex Phellodendri charcoal, 30 parts of Radix Angelicae Sinensis, 30 parts of olibanum, 20 parts of myrrh, 20 parts of rheum officinale, 20 parts of safflower, 50 parts of sunset abelmoschus flower, Asian puccoon 30 parts, 30 parts of folium callicarpae pedunculatae, 30 parts of Akebia Fruit, 20 parts of catechu, 20 parts of acute turpinia leaf, 20 parts of cymose buckwheat rhizome, 20 parts of tuniclike psammosilene root, pearl 20 parts of powder, 20 parts of cape jasmine, 20 parts of Paris polyphylla, 20 parts of lamiophlomis rotata, 20 parts of talcum, 20 parts of cuttlebone, 20 parts of semen coicis, cordate houttuynia 20 Part, 10 parts of borneol, 10 parts of honey, 80 parts of sesame oil.

(1) solid material of the parts by weight is crushed to 300 mesh of fine powder, adjusts pH to 5 with NaAc-HAc buffer solution, Appropriate cellulase is added under the conditions of 45 DEG C, constant temperature digests 20min, and 100 DEG C of inactivations filter at room temperature, obtains filtering powder End；

(2) it filters the extraction of 50% alcohol reflux 2 hours that powder is added 3 times, collects reflux extracting liquid, be concentrated under reduced pressure, spray Mist is dry, obtains mixing powder；

(3) mixing powder is added in the sesame oil of the parts by weight, decocts refining, Oil-temperature control decocts refining 1 hour, oil at 200 DEG C To 100 DEG C, residual oil separation obtains decocting oil refining agent temperature drop；

Toxicological test

It is tested using the rabbit for being equivalent to III degree of burn and scald of human body, the cream of the embodiment of the present invention 1 is applied at scald Agent, thickness 1.2mm are changed primary on the 1st.Again by the detection test blood pressure of rabbit, pulse, whether there is Nausea and vomiting, dizziness Clinical symptoms judge adverse reaction.

The result shows that: every group 5, systolic pressure, diastolic pressure and the pulse of 10 test rabbits are all in normal range (NR) in total It is interior, illustrate that the present invention does not have toxic side effect for rabbit.

Application examples

By the embodiment of the present invention 1~3 be used to treat the paste of skin trauma to different burn and scalds, fall scratch, skin ulcer, The patient of mucosa injury uses random test, and by 1500 Curative effects, as the result is shown: application method according to the invention makes With drug paste provided by the invention, to I, II, III degree of burn and scald, fall scratch, skin ulcer, mucosa injury etc. analgesic go out Bacterium, apocenosis are dispelled, and rotten and blood activating and promoting tissue regeneration is significant in efficacy and simple and easy to do, pain is small, cure rate is high, quick, and thorough treatment is without multiple Hair.I, II, III degree of burn and scald is treated below by the utilization embodiment of the present invention 1~3, falls scratch, skin ulcer and mucosa injury Clinical observation on the therapeutic effect representative instance:

Case 1

Mrs Li, 7 years old, boiled water scald, deep two degree were scalded, and burn surface area 25% carries out debridement, disinfection to patient first, Then the epidermis ruptured already is cut with surgical scissors, on the wound for cutting epidermis, immediately, is used continuously paste 5 days, wound The preliminary healing of mouth, continues to use 7 days, and wound thoroughly heals, and is further continued for consolidating curative effect using 5 days, scar disappears.

Case 2

Hole man, 29 years old, head, neck, auris dextra, the right hand, forearm accounted for body surface area 11% deep two degree and three degree of degree of mixing electricity Arcing wound, trauma surface infestation, purulent secretion is more, after removing purulence to the wound progress debridement, disinfection of patient, applies paste of the present invention In wound, after patient pain significantly disappears, paste is continued to use 20 days, there is pink thin skin film in edge skin in affected part, It being used continuously again 10 days, there is new tissue in burn wound, consolidate spreading 5~10 days, recovery from illness and scar desalination, then apply the present invention 2 months, scar was light to almost not seeing.

Case 3

Wang man 36 years old, falls down accidentally when riding electric vehicle, and by tumble injury, patient pain unbearably, is observed for knee and elbow It can be seen that skin and flesh has frayed, and has badly mutilated shape, there is the entrance of part sandstone.To the wound of patient carry out debridement, disinfection with Afterwards, paste of the present invention is applied in wound, patient pain disappears, while paste formation pseudomembrane can be observed on the surface of wound, and 1 After~2 days, pseudomembrane starts to air-dry, and after 3~4 days, part pseudomembrane is dry and cracked, and dry and cracked ground can see having new meat to grow, and 7 days Afterwards, wound falls knot coffee, after coffee shell is thoroughly fallen, continues to smear paste of the present invention 3~5 days, no scar leaves.

Case 4

Mrs Bai, 50 years old, the right knee joint of careless tumble injury, skin injury, voluntarily oral antibiotic, part were cleaned with salt water After method is handled 2, at the unexpected swelling of knee joint peripheral, skin ulceration and suppurate.Right knee joint is shown in that the skin for having 5 × 4cm size is wiped Wound, part is red and swollen, and wound, which is seen, purulent secretion, after giving drug paste treatment of the invention 2~3 days, thoroughly fully recovers.

1500 patients of tracking verification, men and women patient is average, and the age 28~80 years old, average age 35 years old, medicine of the present invention Object paste to 1500 I, II, III degree of burn and scald, fall scratch, skin ulcer, mucosa injury patient clinical observation on the therapeutic effect result As shown in table 1 below；

1 clinical case analysis and summary of table

Case title	Number of cases	More without scar number after	Scar number is stayed more afterwards	Cure rate (%)	Mean treatment number of days (d)
						Water scald	275	273	2	100	15
Gas scald	192	191	1	100	12
						Fire wound	206	203	3	100	17
Rusting wound	184	181	3	100	21
						Electricity touching wound	115	114	1	100	10
Fall scratch	228	228	0	100	5
						Skin ulcer	169	169	0	100	7
Mucosa injury	131	131	0	100	8
						It is total	1500	1490	10	/	/

By upper table 1 it is found that drug paste provided by the invention, applied to I, II, III degree of burn and scald, fall scratch, skin is burst When ulcer, mucosa injury treatment, cure rate 100% does not stay scar after patient's recovery from illness substantially, and there are mild scars for only a few, through thing Post analysis, a small number of there are the patients that the burned patient of mild scar is deep burn, and the scar that wound leaves compares Gently, it does not scrutinize, is difficult to find.

Above-described embodiment is only more excellent embodiment of the invention, is implemented according to the technical essence of the invention to above Any simple modification, modification and the alternate variation that example is made, belong in the range of technical solution of the present invention.

Claims

1. a kind of Chinese medicine composition for treating skin trauma, which is characterized in that including following raw material: Radix Angelicae Sinensis, polygonum cuspidate, garden burnet Charcoal, Cortex Phellodendri charcoal, olibanum, myrrh, rheum officinale, safflower, borneol, honey and sesame oil.

2. a kind of Chinese medicine composition for treating skin trauma according to claim 1, which is characterized in that including following weight The raw material of part: 50~70 parts of polygonum cuspidate, 50~70 parts of charred RADIX SANGUISORBAE, 50~70 parts of Cortex Phellodendri charcoal, 30~50 parts of Radix Angelicae Sinensis, olibanum 30~50 Part, 20~40 parts of myrrh, 20~40 parts of rheum officinale, 20~40 parts of safflower, 10~20 parts of borneol, 10~20 parts of honey and sesame oil 80~ 100 parts.

3. a kind of Chinese medicine composition for treating skin trauma according to claim 1, which is characterized in that by following parts by weight Raw material composition: 50~70 parts of polygonum cuspidate, 50~70 parts of charred RADIX SANGUISORBAE, 50~70 parts of Cortex Phellodendri charcoal, 30~50 parts of Radix Angelicae Sinensis, olibanum 30~50 Part, 20~40 parts of myrrh, 20~40 parts of rheum officinale, 20~40 parts of safflower, 50~70 parts of sunset abelmoschus flower, 30~50 parts of Asian puccoon, Callicarpa bodinieri Levl. 30~50 parts of leaf, 30~50 parts of Akebia Fruit, 20~40 parts of catechu, 20~40 parts of acute turpinia leaf, 20~40 parts of cymose buckwheat rhizome, tuniclike psammosilene root 20~40 parts, 20~40 parts of pearl powder, 20~40 parts of cape jasmine, 20~40 parts of Paris polyphylla, 20~40 parts of lamiophlomis rotata, talcum 20~40 Part, 20~40 parts of cuttlebone, 20~40 parts of semen coicis, 20~40 parts of cordate houttuynia, 10~20 parts of borneol, 10~20 parts of honey, fiber crops 80~100 parts of oil.

4. a kind of Chinese medicine composition for treating skin trauma according to claim 1, which is characterized in that by following parts by weight Raw material composition: 60 parts of polygonum cuspidate, 60 parts of charred RADIX SANGUISORBAE, 60 parts of Cortex Phellodendri charcoal, 40 parts of Radix Angelicae Sinensis, 40 parts of olibanum, 30 parts of myrrh, rheum officinale 30 Part, 30 parts of safflower, 60 parts of sunset abelmoschus flower, 40 parts of Asian puccoon, 40 parts of folium callicarpae pedunculatae, 40 parts of Akebia Fruit, 30 parts of catechu, acute turpinia leaf 30 Part, 30 parts of cymose buckwheat rhizome, 30 parts of tuniclike psammosilene root, 30 parts of pearl powder, 30 parts of cape jasmine, 30 parts of Paris polyphylla, 30 parts of lamiophlomis rotata, 30 parts of talcum, sea 30 parts of the egg capsule of a mantis, 30 parts of semen coicis, 30 parts of cordate houttuynia, 15 parts of borneol, 15 parts of honey, 90 parts of sesame oil.

5. a kind of preparation method of Chinese medicine composition for treating skin trauma as described in claim 2~4 any one, special Sign is, includes the following steps:

(1) solid material of the parts by weight is crushed to 300~500 mesh of fine powder, adjusts pH to 5 with NaAc-HAc buffer solution ~6, appropriate cellulase is added under the conditions of 45~50 DEG C, and constant temperature digests 20~30min, 100~110 DEG C of inactivations, room temperature Lower suction filtration obtains filtering powder；

(2) it filters the extraction of 50% alcohol reflux 2~4 hours that powder is added 3~5 times, collects reflux extracting liquid, be concentrated under reduced pressure, Spray drying, obtains mixing powder；

(3) mixing powder being added in the sesame oil of the parts by weight, decocts refining, Oil-temperature control decocts refining 1~2 hour at 200~220 DEG C, Oil temperature is down to 100~120 DEG C, and residual oil separation obtains decocting oil refining agent；

6. a kind of Chinese medicine composition for treating skin trauma as described in any one in Claims 1 to 4, which is characterized in that In preparation for treating the application in burn and scald medicine.

7. a kind of Chinese medicine composition application for treating skin trauma as described in any one in Claims 1 to 4, feature exist In in preparation for falling the application in the analgesic drug product in scratch, burn and treatment of scald.

8. a kind of Chinese medicine composition application for treating skin trauma as described in any one in Claims 1 to 4 is used in preparation Application in treatment skin ulcer, mucosa injury drug.

9. a kind of application of Chinese medicine composition for treating skin trauma using the preparation of claim 5 the method, feature exist In in preparation for treating the application in burn and scald medicine.