CN105267411B - A kind of pharmaceutical composition for treating fracture - Google Patents

A kind of pharmaceutical composition for treating fracture Download PDF

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CN105267411B
CN105267411B CN201510113241.1A CN201510113241A CN105267411B CN 105267411 B CN105267411 B CN 105267411B CN 201510113241 A CN201510113241 A CN 201510113241A CN 105267411 B CN105267411 B CN 105267411B
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parts
component
pharmaceutical composition
root
fracture
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CN105267411A (en
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张桂生
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Abstract

The invention discloses a kind of pharmaceutical compositions for treating fracture, belong to technical field of traditional Chinese medicines.The pharmaceutical composition is grouped as by oral component and external application group: the oral component is made of Chinese gall, dried orange peel, myrrh, goldenrod, Cortex Magnoliae Officinalis, vomiting nut, radices trichosanthis, radix rehmanniae preparata, rheum officinale, the root of Dahurain angelica according to certain proportion;The external application component is made according to a certain ratio of native copper, Artemisia anomala, olibanum, Sambucus chinensis, dandelion, fructus gardeniae, scaly holly root, herba lysimachiae, semen coicis, cordate houttuynia, radix dipsaci, rice vinegar.Pharmaceutical composition of the invention can promote meat, muscle growth, and synthetism connects that muscle is rapid, is rapidly achieved the purpose for curing fracture, and therapeutic effect is good, short treating period, and safety is without side-effects.

Description

A kind of pharmaceutical composition for treating fracture
Technical field
The present invention relates to a kind of orthopedic drug, specifically a kind of pharmaceutical composition for treating fracture belongs to Chinese medicine skill Art field.
Background technique
Fracture is mainly bone parts or a kind of disease being broken completely caused by wound, is common Orthopeadic Surgery disease. Currently, being fixed after clinically generalling use operative treatment or bone docking using gypsum, this treatment method relies primarily on patient Autosynthesis ability makes fracture site heal, while being equipped with the drug of activating microcirculation and removing stasis medicinal or anti-inflammatory analgetic class, and growth of spur is slow, controls The treatment period is long, costly, makes patient for a long time by huge pain.And Traditional Chinese Medicine often select to take sanqi tablets, Dieda Wan or The phenomenon that drugs such as lindenleaf torricellia bark or leaf are treated, but administration time is long, and effect is unobvious, generally existing healing slow, Bone nonunion, Thus it is badly in need of the drug that a kind of therapeutic effect is good, and quick treatment is fractured.
Summary of the invention
Aiming at the problems existing in the prior art, the present invention provides a kind of pharmaceutical composition for treating fracture, the drugs Composition includes component for oral administration and is applied with component, treating both manifestation and root cause of disease, can promote meat, muscle growth, and synthetism, to connect muscle rapid, is rapidly achieved The purpose of fracture is cured, therapeutic effect is good, short treating period, and safety is without side-effects.
The invention adopts the following technical scheme:
A kind of pharmaceutical composition for treating fracture, it includes oral component and is applied with component:
The oral component is to be prepared from the following raw materials in parts by weight: 10-20 parts of Chinese gall, 15-30 parts of dried orange peel, myrrh 20-40 parts, it is 10-20 parts of goldenrod, 10-20 parts of Cortex Magnoliae Officinalis, 20-30 parts of vomiting nut, 10-20 parts of radices trichosanthis, 8-15 parts of radix rehmanniae preparata, big It is 8-15 parts yellow, 10-15 parts of the root of Dahurain angelica;
The external application component is to be prepared from the following raw materials in parts by weight: 30-50 parts of native copper, 20-40 parts of Artemisia anomala, cream 10-20 parts fragrant, 10-20 parts of Sambucus chinensis, 15-25 parts of dandelion, 20-30 parts of fructus gardeniae, 20-30 parts of scaly holly root, herba lysimachiae 10-15 Part, 8-12 parts of semen coicis, 8-16 parts of cordate houttuynia, 10-20 parts of radix dipsaci, 120-180 parts of rice vinegar.
Preferably, the pharmaceutical composition of the treatment fracture, it includes oral component and is applied with component:
The oral component is to be prepared from the following raw materials in parts by weight: 15 parts of Chinese gall, 25 parts of dried orange peel, 30 parts of myrrh, 15 parts of goldenrod, 15 parts of Cortex Magnoliae Officinalis, 25 parts of vomiting nut, 15 parts of radices trichosanthis, 12 parts of radix rehmanniae preparata, 12 parts of rheum officinale, 13 parts of the root of Dahurain angelica;
The external application component is to be prepared from the following raw materials in parts by weight: 40 parts of native copper, 30 parts of Artemisia anomala, olibanum 15 Part, 15 parts of Sambucus chinensis, 20 parts of dandelion, 25 parts of fructus gardeniae, 25 parts of scaly holly root, 12 parts of herba lysimachiae, 10 parts of semen coicis, cordate houttuynia 12 Part, 15 parts of radix dipsaci, 150 parts of rice vinegar.
The pharmacological action of drug of the present invention is as follows:
Chinese gall: it is sour, puckery, it is cold in nature;Return lung, large intestine, kidney channel;With astringing lung-QI fall fire, relieving diarrhea with astringents, arrest sweating stops blooding, and receives The effect of wet sore.Dried orange peel: it is bitter, pungent, it is warm-natured;Return lung, the spleen channel;With regulating qi-flowing for strengthening spleen, eliminating dampness and eliminating phlegm effect.Myrrh: it is bitter, It is pungent, it puts down;Enter liver, spleen, the heart, kidney channel;With removing blood stasis and acesodyne, the effect of externally used detumescence myogenic.Goldenrod: it is pungent, bitter, it is cool;Return lung, Liver Channel;With clearing heat and detoxicating, the effect of dispelling wind and heat from the body.Cortex Magnoliae Officinalis: it is bitter, pungent, it is warm-natured;Returns spleen, stomach, lung, large intestine channel;With eliminating dampness The effect of dissolving phlegm, lower gas removes full.Vomiting nut: bitter, temperature;Return liver, the spleen channel;It removes obstruction in channels to relieve pain, the effect of mass dissipating and swelling eliminating.Radices trichosanthis: Sweet, slight bitter, it is slightly cold;It attaches to the lung and stomach meridians;It with clearing heat-fire, promotes the production of body fluid to quench thirst, the effect of detumescence and apocenosis.Radix rehmanniae preparata: sweet, tepor;Return Liver and kidney channel;With yin-nourishing of enriching blood, the effect of life essence-filling, marrow-benefitting.Rheum officinale: bitter, it is cold in nature, it is nontoxic;Returns spleen, stomach, large intestine, liver, pericardium Through;With the logical intestines that purge heat, the effect of removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.The root of Dahurain angelica: acrid flavour, it is warm-natured;Return lung, spleen, stomach meridian;With inducing diaphoresis The effect of cold dispelling, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness stops band, detumescence and apocenosis, dispelling wind and arresting itching.Native copper: it is pungent, it puts down;Return liver warp;Tool There is the effect of removing blood stasis and acesodyne, reunion of fractured tendons and bones.Artemisia anomala: bitter, temperature;Return heart, liver, the spleen channel;With blood-breaking promoting menstruation, the function of healing up sore and subduing swelling Effect.Olibanum: pungent, bitter, temperature;Return heart, liver, the spleen channel;It is relieved pain with blood-activating and qi-promoting, the effect of detumescence and promoting granulation.Sambucus chinensis: warm-natured, bitter; Toil is trembled with fear;With promoting blood circulation to remove blood stasis, the effect of soothing liver and strengthening spleen, dispelling, collateral-activating, sweating diuresis.Dandelion: bitter sweet is trembled with fear;Enter liver, stomach Through;With clearing heat and detoxicating, the effect of diuresis dissipating bind.Fructus gardeniae: it is bitter, it trembles with fear;Enter the heart, liver, lung, stomach meridian;With heat-clearing, purging intense heat is cool The effect of blood.Scaly holly root: it is bitter, sweet, it is cool;Return lung, liver, large intestine channel;The effect of with clearing heat and detoxicating, promoting the production of body fluid to quench thirst, dissipating the stasis of blood.Money Grass: sweet in flavor, slight bitter, it is cool in nature;Return liver, gallbladder, kidney, bladder meridian;Have effects that promoting diuresis for stranguria, clearing heat and detoxicating, eliminating stasis to subdue swelling.Coix lacryma-jobi Benevolence: it is sweet in flavor, light, it is cool in nature;Returns spleen, stomach, lung channel;Advantageous water penetration is wet, invigorating the spleen to arrest diarrhea, eliminating impediment, apocenosis, the effect of detoxicating and resolving a mass. Cordate houttuynia: acrid flavour, it is cold;It is distributed in lung channel;With clearing heat and detoxicating, the effect of inducing diuresis to remove edema.Radix dipsaci: bitter, sweet, pungent, tepor;Return Liver and kidney channel;With nourishing liver and kidney, the effect of promoting circulation of blood arteries and veins, continuous muscles and bones.
In drug of the invention, the oral component the preparation method is as follows:
(1) above-mentioned formula ratio material medicine is weighed according to quantity, is added 800-1000ml cold water soak 1.5-2 hours thereto Afterwards, it is cooked by slow fire again 30 minutes after first being burnt with intense fire to boiling, filters to obtain a filtered juice;
(2) continue into filter residue after adding water 500ml to decoct to boiling 25 minutes, filter to obtain secondary filtered juice;
(3) first and second filtered juice is merged, heating is concentrated into 300ml.
It is described be applied with component the preparation method is as follows:
(1) material medicine in addition to rice vinegar is smashed and ground into powder respectively, is uniformly mixed mixed after crossing 80-100 mesh Close powder;
(2) it takes in formula ratio rice vinegar incorporation mixed powder and is modulated into pasty medicament to obtain the final product.
The usage and dosage of drug of the present invention: the present invention take orally one side of component be it is one, one is one, twice a day, early Respectively take 150ml within 1 hour after supper.It is applied with component: taking the pasty medicament made in advance uniformly to smear and spread on affected part, according to trouble Place's area reasonably adjusts drug dose, and general booth applies with a thickness of 0.5cm or so, then with medical bandage wrapping (should not it is too tight and It is too loose), dressing in 1 day is primary.Oral component is used cooperatively simultaneously with component is applied with, and 10 days are 1 course for the treatment of, and the general 1-4 course for the treatment of is It can cure.
The beneficial effects of the present invention are: all medicine compatibilities of the present invention are scientific and reasonable, which has rationale blood channels and collaterals, The effect of swelling and pain relieving, promoting blood circulation, at the same dual-purpose tonifying Qi promoting circulation of blood, passage, nourishing blood, bactericidal antiphlogistic, myogenic pain relieving drug, from And achieve the effect that growth of spur, broken stasis of blood synthetism, continuous muscle can be rapidly promoted.All kinds of fracture of the drug therapy are quick, healing Effect is good, has no toxic side effect.
Specific embodiment
The present invention is described in further detail combined with specific embodiments below.
Embodiment 1
A kind of pharmaceutical composition for treating fracture, it includes oral component and is applied with component:
Oral component is made of the bulk pharmaceutical chemicals of following weight: Chinese gall 10g, dried orange peel 15g, myrrh 20g, goldenrod 10g, Cortex Magnoliae Officinalis 10g, vomiting nut 20g, radices trichosanthis 10g, radix rehmanniae preparata 8g, rheum officinale 8g, root of Dahurain angelica 10g.
Be applied with component be made of the bulk pharmaceutical chemicals of following weight: native copper 30g, Artemisia anomala 20g, olibanum 10g, Sambucus chinensis 10g, Dandelion 15g, fructus gardeniae 20g, scaly holly root 20g, herba lysimachiae 10g, semen coicis 8g, cordate houttuynia 8g, radix dipsaci 10g, rice vinegar 120g.
Said medicine take orally component the preparation method is as follows:
(1) above-mentioned formula ratio material medicine is weighed according to quantity, is added 800-1000ml cold water soak 1.5-2 hours thereto Afterwards, it is cooked by slow fire again 30 minutes after first being burnt with intense fire to boiling, filters to obtain a filtered juice;
(2) continue into filter residue after adding water 500ml to decoct to boiling 25 minutes, filter to obtain secondary filtered juice;
(3) first and second filtered juice is merged, heating is concentrated into 300ml.
Said medicine be applied with component the preparation method is as follows:
(1) material medicine in addition to rice vinegar is smashed and ground into powder respectively, is uniformly mixed mixed after crossing 80-100 mesh Close powder;
(2) it takes in formula ratio rice vinegar incorporation mixed powder and is modulated into pasty medicament to obtain the final product.
Embodiment 2
A kind of pharmaceutical composition for treating fracture, it includes oral component and is applied with component:
Oral component is made of the bulk pharmaceutical chemicals of following weight: Chinese gall 15g, dried orange peel 25g, myrrh 30g, goldenrod 15g, Cortex Magnoliae Officinalis 15g, vomiting nut 25g, radices trichosanthis 15g, radix rehmanniae preparata 12g, rheum officinale 12g, root of Dahurain angelica 13g.
Be applied with component be made of the bulk pharmaceutical chemicals of following weight: native copper 40g, Artemisia anomala 30g, olibanum 15g, Sambucus chinensis 15g, Dandelion 20g, fructus gardeniae 25g, scaly holly root 25g, herba lysimachiae 12g, semen coicis 10g, cordate houttuynia 12g, radix dipsaci 15g, rice vinegar 150g.
The preparation method is the same as that of Example 1 for the present embodiment pharmaceutical composition.
Embodiment 3
A kind of pharmaceutical composition for treating fracture, it includes oral component and is applied with component:
Oral component is made of the bulk pharmaceutical chemicals of following weight: Chinese gall 20g, dried orange peel 30g, myrrh 40g, goldenrod 20g, Cortex Magnoliae Officinalis 20g, vomiting nut 30g, radices trichosanthis 20g, radix rehmanniae preparata 15g, rheum officinale 15g, root of Dahurain angelica 15g;
Be applied with component be made of the bulk pharmaceutical chemicals of following weight: native copper 50g, Artemisia anomala 40g, olibanum 20g, Sambucus chinensis 20g, Dandelion 25g, fructus gardeniae 30g, scaly holly root 30g, herba lysimachiae 15g, semen coicis 12g, cordate houttuynia 16g, radix dipsaci 20g, rice vinegar 180g.
The preparation method is the same as that of Example 1 for the present embodiment pharmaceutical composition.
Embodiment 4
A kind of pharmaceutical composition for treating fracture, it includes oral component and is applied with component:
Oral component is made of the bulk pharmaceutical chemicals of following weight: Chinese gall 18g, dried orange peel 25g, myrrh 35g, goldenrod 18g, Cortex Magnoliae Officinalis 15g, vomiting nut 24g, radices trichosanthis 12g, radix rehmanniae preparata 10g, rheum officinale 10g, root of Dahurain angelica 12g.
Be applied with component be made of the bulk pharmaceutical chemicals of following weight: native copper 45g, Artemisia anomala 35g, olibanum 18g, Sambucus chinensis 15g, Dandelion 22g, fructus gardeniae 27g, scaly holly root 28g, herba lysimachiae 10g, semen coicis 9g, cordate houttuynia 14g, radix dipsaci 18g, rice vinegar 160g.
The preparation method is the same as that of Example 1 for the present embodiment pharmaceutical composition.
Clinical application example
1. clinical data: randomly selecting outpatient service and accept fracture patient 260 for medical treatment, mostly fracture caused by external force.Wherein male 155 Example, female 105, the age, average age was 38 years old at 15-55 years old.
2. diagnostic criteria: can be made a definite diagnosis according to clinical manifestation and imageological examination.
3. treatment method: using drug made from the embodiment of the present invention 2, oral component cooperates simultaneously with external application component and makes With 10 days are 1 course for the treatment of.Oral one side of component be it is one, one is one, twice a day, respectively takes 150ml within 1 hour after morning and evening dinner. It is applied with component: taking the pasty medicament made in advance uniformly to smear and spread on affected part, drug dose is reasonably adjusted according to affected part area, General booth applies with a thickness of 0.5cm or so, then with medical bandage wrapping (should not be too tight and too loose), dressing in 1 day 1 time.General 1-4 A course for the treatment of can cure.
4. curative effect determinate standard:
Cure: using X-ray image as foundation, fracture line is fuzzy, has continuous poroma by fracture line, and swelling pain sense disappears, Patient can normally move freely.
Improve: poroma is formed obviously, wraps fracture site, and swelling pain sense disappears, and patient can be with local movement.
Invalid: no poroma forms or has a small amount of poroma to be formed, and swelling pain sense is obvious.
5. treatment results: being shown in Table 1.
1 clinical treatment outcome of table
Case Cure n Improvement n Invalid n Total effective n(%)
260 223 36 1 149(99.6)
It can be seen from the results above that pharmaceutical composition of the invention treats fracture patient 260, as a result cure It 223, improves 36, invalid 1, total effective rate is up to 99.6%.
Typical case
Example 1: Lee, female, 24 years old, patient felt that right elbow continues severe pain in being wounded on the way to office by electro-tricycle after wound, Without radiation, limitation of activity sends medical rear x-ray inspection to hospital and is diagnosed as right humerus comminuted fracture of lower end.Manipulative reduction is fixed Afterwards, it is applied with liniment made from the embodiment of the present invention 2, while being equipped with after oral component treats 1 course for the treatment of, feeling of pain mitigates big Half, local swelling is vanished from sight substantially, after continue to use patient's activity such as ordinary person after 2 courses for the treatment of of pharmaceutical composition of the present invention.
Example 2: Cai so-and-so, male, 55 years old, patient fell from stair injured accidentally, feels right hip duration severe pain after wound, living Dynamic limited, cannot stand walking.Right fracture of neck of femur is shown through x-ray inspection.Through the pharmaceutical composition for using the embodiment of the present invention 3 After 2 courses for the treatment of, patient's recovery from illness.
Example 3: even certain, male, 20 years old, patient drove car and knocks into the back with front truck and causes left leg swelling obvious, can and bone wiping Sound and bone rubbing feeling, x-ray inspection show left leg fracture of shaft of tibia.After manipulative reduction, the drug that is prepared using the embodiment of the present invention 1 After 1 course for the treatment of of composition, patient's swelling and feeling of pain disappear most, and patient fully recovers after continuing to use 3 courses for the treatment of of drug of the present invention, Activity is freely.
Example 4: Chen, female, 16 years old, patient occurred right lower extremity bleeding, pain and with right thigh swelling from after high falling, living It is dynamic limited.Right side fracture of femoral shaft is diagnosed as through x-ray inspection.The drug of the embodiment of the present invention 4 is used after gimmick replacement and fixation After 1 course for the treatment of of composition, swelling, feeling of pain disappear more than half, and X-ray examination poroma is formed obviously, patient can local movement, it is subsequent Continue using after 2 courses for the treatment of of drug of the invention, clinical symptoms all disappear, and patient can be with normal activity.

Claims (2)

1. a kind of pharmaceutical composition for treating fracture, which is characterized in that it is grouped as by oral component and external application group:
The oral component is to be prepared from the following raw materials in parts by weight: 10-20 parts of Chinese gall, 15-30 parts of dried orange peel, myrrh 20- 40 parts, 10-20 parts of goldenrod, 10-20 parts of Cortex Magnoliae Officinalis, 20-30 parts of vomiting nut, 10-20 parts of radices trichosanthis, 8-15 parts of radix rehmanniae preparata, rheum officinale 8-15 parts, 10-15 parts of the root of Dahurain angelica;
The external application component is to be prepared from the following raw materials in parts by weight: 30-50 parts of native copper, 20-40 parts of Artemisia anomala, olibanum 10-20 parts, 10-20 parts of Sambucus chinensis, 15-25 parts of dandelion, 20-30 parts of fructus gardeniae, 20-30 parts of scaly holly root, 10-15 parts of herba lysimachiae, 8-12 parts of semen coicis, 8-16 parts of cordate houttuynia, 10-20 parts of radix dipsaci, 120-180 parts of rice vinegar.
2. the pharmaceutical composition for the treatment of fracture according to claim 1, which is characterized in that it is by oral component and external application Group is grouped as:
The oral component is to be prepared from the following raw materials in parts by weight: 15 parts of Chinese gall, 25 parts of dried orange peel, 30 parts, one of myrrh 15 parts of chrysanthemum, 15 parts of Cortex Magnoliae Officinalis, 25 parts of vomiting nut, 15 parts of radices trichosanthis, 12 parts of radix rehmanniae preparata, 12 parts of rheum officinale, 13 parts of the root of Dahurain angelica;
The external application component is to be prepared from the following raw materials in parts by weight: 40 parts of native copper, 30 parts of Artemisia anomala, 15 parts of olibanum, land 15 parts of English, 20 parts of dandelion, 25 parts of fructus gardeniae, 25 parts of scaly holly root, 12 parts of herba lysimachiae, 10 parts of semen coicis, 12 parts of cordate houttuynia, radix dipsaci 15 parts, 150 parts of rice vinegar.
CN201510113241.1A 2015-03-16 2015-03-16 A kind of pharmaceutical composition for treating fracture Expired - Fee Related CN105267411B (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1435188A (en) * 2002-01-28 2003-08-13 张作明 Bone-setting instant granules and capsules, and preparing process thereof
CN1565526A (en) * 2003-06-19 2005-01-19 程时林 Orthopedic external application paste integrating functions of relieving pain, diminishing swelling and promoting bone healing
CN102343076A (en) * 2011-10-14 2012-02-08 玉林市骨科医院 Traumatic injury treatment ointment medicament for external application and production method thereof
CN103417780A (en) * 2013-08-08 2013-12-04 周杰山 Bone fracture treatment plaster

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1435188A (en) * 2002-01-28 2003-08-13 张作明 Bone-setting instant granules and capsules, and preparing process thereof
CN1565526A (en) * 2003-06-19 2005-01-19 程时林 Orthopedic external application paste integrating functions of relieving pain, diminishing swelling and promoting bone healing
CN102343076A (en) * 2011-10-14 2012-02-08 玉林市骨科医院 Traumatic injury treatment ointment medicament for external application and production method thereof
CN103417780A (en) * 2013-08-08 2013-12-04 周杰山 Bone fracture treatment plaster

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Granted publication date: 20190326