CN102343076A - Traumatic injury treatment ointment medicament for external application and production method thereof - Google Patents
Traumatic injury treatment ointment medicament for external application and production method thereof Download PDFInfo
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- CN102343076A CN102343076A CN2011103107242A CN201110310724A CN102343076A CN 102343076 A CN102343076 A CN 102343076A CN 2011103107242 A CN2011103107242 A CN 2011103107242A CN 201110310724 A CN201110310724 A CN 201110310724A CN 102343076 A CN102343076 A CN 102343076A
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Abstract
The invention discloses a traumatic injury treatment ointment medicament for external application and a production method thereof. The medicament consists of rhubarb, dahurian angelica root, turmeric, amur corktree bark, Mongolian snakegourd root, dried orange peel, Chinese atractylodes, crude pedate pinallia jackinthepulpit rhizome, liquoric root, officinal magnolia bark, vaseline and borneol serving as raw materials. The production method comprises the following steps of: weighing rhubarb, dahurian angelica root, turmeric, amur corktree bark, Mongolian snakegourd root, dried orange peel, Chinese atractylodes, crude pedate pinallia jackinthepulpit rhizome, liquoric root and officinal magnolia bark according to a prescription, and smashing into fine powder of 80 meshes which can pass through a No.5 sieve for later use; heating vaseline for melting, adding the fine powder into the thermally-molten vaseline, and continuously stirring uniformly; and cooling to about 70 DEG C, adding borneol, stirring uniformly and performing split charging. The medicament is used for treating various traumatic injuries, particularly has a remarkable and stable curative effect on initial-stage stable fracture, is convenient to use, does not have other untoward reactions, and has a simple production process, stable finished product quality and low price.
Description
Technical field
The present invention relates to a kind of linear Chinese medicine composition that is used to treat traumatic injury, soft tissue injury; More particularly; Relate to a kind of traumatic injury that is used to treat, soft tissue injury is especially for early stage Traditional Chinese Medicine for external application ointment and the production method thereof of treatment closed fracture.
Background technology
At present, at treatment traumatic injury, soft tissue injury, on the early stage pharmaceutical market of treatment stable fracture, the Chinese medicine ointment that is used for external application for curing seldom.Particularly still less, mostly wipe outward with medicated wine to the medicine of each of fracture treatment in stage.Apply medicinal lotion or ointment outward and generally all be to use the medicated wine of high spirit infusion; Requiring when controlling firmly rubs is beneficial to drug absorption to generating heat executing; The misery that causes when so not only making the patient tolerate owing to friction, and much the people can produce skin allergy, and treatment can't be proceeded.And in the western medical treatment method,, cause accumulation in vivo easily because used Western medicine all is a synthetic drug, particularly some hormone medicines can produce various sequela to human body.So much human all is unwilling to use, so people urgently hope to develop the outer application medicine for treating traumatic injury that a kind of reducing swelling and alleviating pain soon, can not cause side effect.
Summary of the invention
Provide in the objective of the invention is to a kind of pure Chinese medicine, instant effect, can not cause the outer application medicine for treating traumatic injury of side effect.Particularly to provide a kind of can be early stage to stable fracture, Traditional Chinese Medicine for external application ointment and production method thereof that the soft tissue injury reducing swelling and alleviating pain has promising result.
The inventor uses the traditional Chinese medical science, Chinese medicine rationale in order to achieve the above object, aspect the medication of the side of choosing, has carried out deep research and experiment.The result finds; Utilization is main with Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Cortex Phellodendri; The pharmaceutical composition of forming in specific ratio with Radix Trichosanthis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Arisaema Cum Bile, Radix Glycyrrhizae, Cortex Magnoliae Officinalis etc. 6 flavor accessory drugss and vaseline, Borneolum Syntheticum can reach the effect of reducing swelling and alleviating pain, removing pathogenic heat from blood and toxic substance from the body through external application, can improve patient's clinical symptoms, sign more effectively.Thereby make the local reducing swelling and alleviating pain of patient, the reduction of the fracture is good, thereby because this test result has been accomplished the present invention.
Technical scheme of the present invention is following:
1. an outer application ointment medicine for treating traumatic injury is characterized in that wherein the proportioning of various material compositions is following: Radix Et Rhizoma Rhei 30-50 mass parts, Radix Angelicae Dahuricae 30-50 mass parts, Rhizoma Curcumae Longae 30-50 mass parts, Cortex Phellodendri 30-50 mass parts, Radix Trichosanthis 60-100 mass parts, Pericarpium Citri Reticulatae 10-30 mass parts, Rhizoma Atractylodis 10-30 mass parts, Arisaema Cum Bile 20-50 mass parts, Radix Glycyrrhizae 30-50 mass parts, Cortex Magnoliae Officinalis 30-50 mass parts, vaseline 500-800 mass parts, Borneolum Syntheticum 2-5 mass parts.
2. according to the described outer application ointment medicine for treating traumatic injury of claim 1, it is characterized in that wherein the proportioning of various material compositions is following: Radix Et Rhizoma Rhei 41 mass parts, the Radix Angelicae Dahuricae 41 mass parts, Rhizoma Curcumae Longae 41 mass parts, Cortex Phellodendri 41 mass parts, Radix Trichosanthis 82 mass parts, Pericarpium Citri Reticulatae 16 mass parts, Rhizoma Atractylodis 16 mass parts, Arisaema Cum Bile 34 mass parts, Radix Glycyrrhizae 16 mass parts, Cortex Magnoliae Officinalis 16 mass parts, vaseline 660 mass parts, Borneolum Syntheticum 2 mass parts.
3. the production method of an outer application ointment medicine for treating traumatic injury; It is characterized in that this method comprises following step: (1) is ready to Radix Et Rhizoma Rhei 30-50 mass parts, Radix Angelicae Dahuricae 30-50 mass parts, Rhizoma Curcumae Longae 30-50 mass parts, Cortex Phellodendri 30-50 mass parts, Radix Trichosanthis 60-100 mass parts, Pericarpium Citri Reticulatae 10-30 mass parts, Rhizoma Atractylodis 10-30 mass parts, Arisaema Cum Bile 20-50 mass parts, Radix Glycyrrhizae 30-50 mass parts, Cortex Magnoliae Officinalis 30-50 mass parts, vaseline 500-800 mass parts, the Borneolum Syntheticum 2-5 mass parts as raw material; (2) take by weighing recipe quantity Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Cortex Phellodendri, Radix Trichosanthis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Arisaema Cum Bile, Radix Glycyrrhizae, Cortex Magnoliae Officinalis; It is subsequent use to be ground into No. 5 sieve 80 order fine powders; (3) with vaseline 500 mass parts; Heat fused, and above-mentioned subsequent use fine powder added the vaseline of heat fusing, constantly stir; (4) to be cooledly add Borneolum Syntheticum 2 mass parts to 50-90 ℃ and stir packing.
4. according to the production method of the described outer application ointment medicine for treating traumatic injury of claim 3, it is characterized in that wherein the proportioning of various material compositions is following: Radix Et Rhizoma Rhei 41 mass parts, the Radix Angelicae Dahuricae 41 mass parts, Rhizoma Curcumae Longae 41 mass parts, Cortex Phellodendri 41 mass parts, Radix Trichosanthis 82 mass parts, Pericarpium Citri Reticulatae 16 mass parts, Rhizoma Atractylodis 16 mass parts, Arisaema Cum Bile 34 mass parts, Radix Glycyrrhizae 16 mass parts, Cortex Magnoliae Officinalis 16 mass parts, vaseline 660 mass parts, Borneolum Syntheticum 2 mass parts.
5. according to the described outer application ointment medicine for treating traumatic injury production method of claim 3, it is characterized in that step (2) takes by weighing recipe quantity Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Cortex Phellodendri, Radix Trichosanthis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Arisaema Cum Bile, Radix Glycyrrhizae, Cortex Magnoliae Officinalis, it is subsequent use to be ground into No. 5 sieve 80 order fine powders; (3) with vaseline 800 mass parts; Heat fused, and above-mentioned subsequent use fine powder added the vaseline of heat fusing, constantly stir; (4) to be cooledly add Borneolum Syntheticum 5 mass parts to 50-90 ℃ and stir packing.
6. according to claim 3 or 5 described outer application ointment medicine for treating traumatic injury production methods, what it is characterized in that step (4) to be cooledly adds Borneolum Syntheticum to 50-90 ℃ and stirs packing.
Beneficial effect of the present invention is following:
(1) to various traumatic injury treatments, especially stable fracture had remarkable and stable curative effect in early days.
(2) fixation is played in external application after the reduction of the fracture, easy to use.
(3) there is not other untoward reaction.
(4) production technology is simple, and end product quality is stable.
(5) cheap.
The specific embodiment
Enumerate embodiment and clinical practice example below and come further to explain the present invention:
1. this preparation recipe principle: Radix Et Rhizoma Rhei is cold in nature in the side; Bitter in the mouth.Removing pathogenic heat from blood and toxic substance from the body is arranged, the effect of eliminating blood stasis and inducing menstruation.Cure mainly carbuncle and treat skin ulcer, traumatic injury etc.Be the monarch drug in the side.Rhizoma Curcumae Longae is warm in nature; Acrid in the mouth, hardship.The removing blood stasis circulation of qi promoting is arranged, the inducing menstruation to relieve menalgia effect.Cure mainly rheumatism shoulder arm pain, treating swelling and pain by traumatic injury.Cortex Phellodendri is cold in nature; Bitter in the mouth.Heat clearing and damp drying is arranged, and the skin ulcer function is treated in detoxifcation, cures mainly damp-heat dysentery, ministerial drug in the sore swollen toxin side of being.The Radix Trichosanthis cold nature; Sweet and slightly bitter taste.The merit that detumescence and apocenosis is arranged, the treatment of ulcer toxic swelling, Pericarpium Citri Reticulatae is warm in nature; Bitter in the mouth, suffering.The merit that has circulation of qi promoting to regulate the flow of vital energy, it is full etc. to cure mainly the breast wrist that expands.Rhizoma Atractylodis are warm in nature; Acrid in the mouth.The merit of expelling wind and cold is arranged, cure mainly rheumatic arthralgia.Cortex Magnoliae Officinalis is warm in nature; Bitter in the mouth, suffering.The dampness expectorant is arranged, and the therapeutic method to keep the adverse QI flowing downwards is removed full merit, cures mainly stagnation of QI due to dyspepsia etc.Rhizoma Arisaematis is warm in nature; Bitter in the mouth, suffering.Have and expelling wind and relieving convulsion, the merit of mass dissipating and swelling eliminating cures mainly hemiplegia, gives birth to and uses the external treatment carbuncle.Be adjuvant drug in the side altogether.Radix Glycyrrhizae property is flat; Sweet in the mouth.Heat-clearing and toxic substances removing is arranged, and the merit of coordinating the actions of various ingredients in a prescription cures mainly the anxious pain of extremity contraction, and carbuncle sore tumefacting virus is messenger drug in the side.All medicine compatibilities are played reducing swelling and alleviating pain, the effect of heat-clearing and toxic substances removing altogether.Be used to treat traumatic injury, soft tissue injury, skin infection swell and ache etc.
2. each medicine of this preparation is in the scope of application of Chinese Pharmacopoeia: Radix Et Rhizoma Rhei 3-15g, Radix Angelicae Dahuricae 3-10g, Rhizoma Curcumae Longae 3-10g, Cortex Phellodendri 3-12g, Radix Trichosanthis 10-15g, Pericarpium Citri Reticulatae 3-10g, Rhizoma Atractylodis 3-9g, Arisaema Cum Bile 3-15g, Radix Glycyrrhizae 2-10g, Cortex Magnoliae Officinalis 3-10g.
From the single medicinal material to the compatibility, use, passed through my institute and put into practice for a long time and progressively sum up, thereby confirmed as best component proportion, clinical practice reaches optimum efficiency.It is the principal mode of middle medical drugs that the compatibility of medicine is used, and medicine makes up by certain law, and confirms certain component proportion, processes appropriate dosage forms, also is the higher form that compatibility of drugs is used.
Embodiment 1
In the Radix Et Rhizoma Rhei 30-50 of various material compositions mass parts, Radix Angelicae Dahuricae 30-50 mass parts, Rhizoma Curcumae Longae 30-50 mass parts, Cortex Phellodendri 30-50 mass parts, Radix Trichosanthis 60-100 mass parts, Pericarpium Citri Reticulatae 10-30 mass parts, Rhizoma Atractylodis 10-30 mass parts, Arisaema Cum Bile 20-50 mass parts, Radix Glycyrrhizae 30-50 mass parts, Cortex Magnoliae Officinalis 30-50 mass parts, vaseline 500-800 mass parts, Borneolum Syntheticum 2-5 mass parts.Take by weighing recipe quantity Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Cortex Phellodendri, Radix Trichosanthis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Arisaema Cum Bile, Radix Glycyrrhizae, Cortex Magnoliae Officinalis, it is subsequent use to be ground into No. 5 sieve 80 order fine powders.With vaseline 660g, heating (45 ℃～60 ℃) fusing, and will be above-mentioned subsequent use fine powder adds the vaseline of heat fusing, constantly stirs, at this moment ointment relative density 0.97 (60 ℃).To be cooledly add Borneolum Syntheticum 2g to about 50-90 ℃ and stir packing.
Embodiment 2:
Take by weighing recipe quantity Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Cortex Phellodendri, Radix Trichosanthis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Arisaema Cum Bile, Radix Glycyrrhizae, Cortex Magnoliae Officinalis, it is subsequent use to be ground into No. 5 sieve 80 order fine powders.With vaseline 500g, heating (45 ℃～60 ℃) fusing, and will be above-mentioned subsequent use fine powder adds the vaseline of heat fusing, constantly stirs, at this moment ointment relative density 0.99 (60 ℃).To be cooledly add Borneolum Syntheticum 3g to about 50-90 ℃ and stir packing.
Embodiment 3:
Take by weighing recipe quantity Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Cortex Phellodendri, Radix Trichosanthis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Arisaema Cum Bile, Radix Glycyrrhizae, Cortex Magnoliae Officinalis, it is subsequent use to be ground into No. 5 sieve 80 order fine powders.With vaseline 800g, heating (45 ℃～60 ℃) fusing, and will be above-mentioned subsequent use fine powder adds the vaseline of heat fusing, constantly stirs, at this moment ointment relative density 0.96 (60 ℃).To be cooledly add Borneolum Syntheticum 5g to about 50-90 ℃ and stir packing.
The clinical practice example
2,4,6 three lesiones of in-patient department of the inventor location city-level hospitals of traditional Chinese and western medicine (Yulin City of Guangxi Zhuang Autonomous orthopaedics hospital), resetting afterwards to stable fracture, use golden yellow ointment of the present invention has carried out hospitalization and clinical observation record to 100 example fracture early stage patients.
In this group patient 100 examples, male's 62 examples, women's 38 examples are the age in the 20-55 adult patients in year.The course of disease is for hindering the back 1-3 days.
The clinical symptoms sign of fracture early stage patient is roughly following: case: chi, fracture of radius are 35 examples, and shin, fracture of fibula are 32 examples, humeral shaft fracture 33 examples, patient's local swelling pain.
This is organized 100 routine patients and uses golden yellow ointment of the present invention, golden yellow ointment is spread out on gauze, paste the affected part, whenever changes dressings once at a distance from 2～3 days.Continuous external application 2-3 week.
Undertaken by People's Republic of China's pharmaceuticals industry standard " disease of tcm diagnosis criterion of therapeutical effect " when during treating, carrying out clinical observation.All itemized record are on record for symptoms, sign, lab testing result, adverse effect etc.Observe to this course of treatment always and finish.
After being admitted to hospital, all observation case fracture patients all make routine blood test, routine urinalysis, fecal occult blood, liver function, renal function, Electrocardioscopy and X line fluoroscopic examination.
Curative effect judging standard:
1. cure: hinder the limb local stasis of blood, swelling is disappeared basically, pain disappears basically, and fracture site tentatively connects.
2. take a turn for the better: hinder the limb local stasis of blood, tumor disappears, pain relief, fracture site has connection.
3. do not heal: hinder limb local stasis of blood, swelling and do not see and disappear, pain is not seen and is alleviated.
Therapeutic outcome: in whole 100 routine stable fracture initial stage patients, by above-mentioned usage and dosage external application 2-3 week, the patient hinders the limb local stasis of blood, swelling is disappeared basically, and pain disappears basically, and fracture site tentatively connects.Cure and account for 90%, improvement 10%.
Can find out that from above-mentioned experimental result golden yellow ointment of the present invention has curative effect preferably for the stable fracture initial stage, the clinical effect that has obtained satisfaction.
Claims (6)
1. an outer application ointment medicine for treating traumatic injury is characterized in that wherein the proportioning of various material compositions is following: Radix Et Rhizoma Rhei 30-50 mass parts, Radix Angelicae Dahuricae 30-50 mass parts, Rhizoma Curcumae Longae 30-50 mass parts, Cortex Phellodendri 30-50 mass parts, Radix Trichosanthis 60-100 mass parts, Pericarpium Citri Reticulatae 10-30 mass parts, Rhizoma Atractylodis 10-30 mass parts, Arisaema Cum Bile 20-50 mass parts, Radix Glycyrrhizae 30-50 mass parts, Cortex Magnoliae Officinalis 30-50 mass parts, vaseline 500-800 mass parts, Borneolum Syntheticum 2-5 mass parts.
2. according to the described outer application ointment medicine for treating traumatic injury of claim 1, it is characterized in that wherein the proportioning of various material compositions is following: Radix Et Rhizoma Rhei 41 mass parts, the Radix Angelicae Dahuricae 41 mass parts, Rhizoma Curcumae Longae 41 mass parts, Cortex Phellodendri 41 mass parts, Radix Trichosanthis 82 mass parts, Pericarpium Citri Reticulatae 16 mass parts, Rhizoma Atractylodis 16 mass parts, Arisaema Cum Bile 34 mass parts, Radix Glycyrrhizae 16 mass parts, Cortex Magnoliae Officinalis 16 mass parts, vaseline 660 mass parts, Borneolum Syntheticum 2 mass parts.
3. the production method of an outer application ointment medicine for treating traumatic injury; It is characterized in that this method comprises following step: (1) is ready to Radix Et Rhizoma Rhei 30-50 mass parts, Radix Angelicae Dahuricae 30-50 mass parts, Rhizoma Curcumae Longae 30-50 mass parts, Cortex Phellodendri 30-50 mass parts, Radix Trichosanthis 60-100 mass parts, Pericarpium Citri Reticulatae 10-30 mass parts, Rhizoma Atractylodis 10-30 mass parts, Arisaema Cum Bile 20-50 mass parts, Radix Glycyrrhizae 30-50 mass parts, Cortex Magnoliae Officinalis 30-50 mass parts, vaseline 500-800 mass parts, the Borneolum Syntheticum 2-5 mass parts as raw material; (2) take by weighing recipe quantity Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Cortex Phellodendri, Radix Trichosanthis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Arisaema Cum Bile, Radix Glycyrrhizae, Cortex Magnoliae Officinalis; It is subsequent use to be ground into No. 5 sieve 80 order fine powders; (3) with vaseline 500 mass parts; Heat fused, and above-mentioned subsequent use fine powder added the vaseline of heat fusing, constantly stir; (4) to be cooledly add Borneolum Syntheticum 2 mass parts to 50-90 ℃ and stir packing.
4. according to the production method of the described outer application ointment medicine for treating traumatic injury of claim 3, it is characterized in that wherein the proportioning of various material compositions is following: Radix Et Rhizoma Rhei 41 mass parts, the Radix Angelicae Dahuricae 41 mass parts, Rhizoma Curcumae Longae 41 mass parts, Cortex Phellodendri 41 mass parts, Radix Trichosanthis 82 mass parts, Pericarpium Citri Reticulatae 16 mass parts, Rhizoma Atractylodis 16 mass parts, Arisaema Cum Bile 34 mass parts, glycosides grass 16 mass parts, Cortex Magnoliae Officinalis 16 mass parts, vaseline 660 mass parts, Borneolum Syntheticum 2 mass parts.
5. according to the production method of the described outer application ointment medicine for treating traumatic injury of claim 3, it is characterized in that step (2) takes by weighing recipe quantity Radix Et Rhizoma Rhei, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Cortex Phellodendri, Radix Trichosanthis, Pericarpium Citri Reticulatae, Rhizoma Atractylodis, Arisaema Cum Bile, Radix Glycyrrhizae, Cortex Magnoliae Officinalis, it is subsequent use to be ground into No. 5 sieve 80 order fine powders; (3) with vaseline 800 mass parts; Heat fused, and above-mentioned subsequent use fine powder added the vaseline of heat fusing, constantly stir; (4) to be cooledly add Borneolum Syntheticum 5 mass parts to 50-90 ℃ and stir packing.
6. according to the production method of claim 3 or 5 described outer application ointment medicine for treating traumatic injury, what it is characterized in that step (4) to be cooledly adds Borneolum Syntheticum to 50-90 ℃ and stirs packing.
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Cited By (6)
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| CN103566098A (en) * | 2013-10-15 | 2014-02-12 | 姜席赋 | External specific detumescence ointment formula for orthopedics |
| CN105267411A (en) * | 2015-03-16 | 2016-01-27 | 张桂生 | Medicine composition for treating fracture |
| CN105456399A (en) * | 2015-12-16 | 2016-04-06 | 张安琪 | Traditional Chinese medicine composition for treating traumatic injuries and preparation method thereof |
| CN109481608A (en) * | 2018-12-29 | 2019-03-19 | 黄昆 | A kind of golden yellow finish compound of Liang Shi and its preparation process |
| CN112121134A (en) * | 2020-08-26 | 2020-12-25 | 王利娟 | Traditional Chinese medicine composition for treating joint cavity effusion and preparation method thereof |
| CN113082151A (en) * | 2021-05-06 | 2021-07-09 | 彭朝兴 | External Chinese herbal medicine composition for bone fracture, preparation and preparation method and application thereof |
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2011
- 2011-10-14 CN CN2011103107242A patent/CN102343076A/en active Pending
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103566098A (en) * | 2013-10-15 | 2014-02-12 | 姜席赋 | External specific detumescence ointment formula for orthopedics |
| CN105267411A (en) * | 2015-03-16 | 2016-01-27 | 张桂生 | Medicine composition for treating fracture |
| CN105267411B (en) * | 2015-03-16 | 2019-03-26 | 张桂生 | A kind of pharmaceutical composition for treating fracture |
| CN105456399A (en) * | 2015-12-16 | 2016-04-06 | 张安琪 | Traditional Chinese medicine composition for treating traumatic injuries and preparation method thereof |
| CN109481608A (en) * | 2018-12-29 | 2019-03-19 | 黄昆 | A kind of golden yellow finish compound of Liang Shi and its preparation process |
| CN112121134A (en) * | 2020-08-26 | 2020-12-25 | 王利娟 | Traditional Chinese medicine composition for treating joint cavity effusion and preparation method thereof |
| CN113082151A (en) * | 2021-05-06 | 2021-07-09 | 彭朝兴 | External Chinese herbal medicine composition for bone fracture, preparation and preparation method and application thereof |
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Application publication date: 20120208 |