CN102697928B - Preparation method for medicine composition for treating traumatic injury - Google Patents

Preparation method for medicine composition for treating traumatic injury Download PDF

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CN102697928B
CN102697928B CN201210197567.3A CN201210197567A CN102697928B CN 102697928 B CN102697928 B CN 102697928B CN 201210197567 A CN201210197567 A CN 201210197567A CN 102697928 B CN102697928 B CN 102697928B
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radix angelicae
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CN102697928A (en
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潘杰
黄进明
洪绯
罗志毅
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Zhangzhou Pientzehuang Pharmaceutical Co Ltd
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Abstract

The invention discloses a preparation method for a medicine composition for treating traumatic injury. The medicine composition for treating the traumatic injury comprises the following crude drugs in parts by weight: 8-28 parts of pseudo-ginseng, 4-14 parts of angelica sinensis, 4-14 parts of myrrh, 4-14 parts of eucommia ulmoides, 4-14 parts of rhizoma cibotii, 4-14 parts of herba lycopi, 4-14 parts of notopterygium root, 4-14 parts of radix angelicae pubescentis, 4-14 parts of golden cypress, 4-14 parts of erythrina indica lam and 4-14 parts of fried frankincense. The preparation method for the medicine composition for treating the traumatic injury comprises the following steps of mixing and crushing the eleven crude drugs into a coarse powder; adding 800 parts of alcohol (55 percent) in parts by weight and soaking for 12-48 hours; then, heating a liquid medicine and keeping the temperature of the liquid medicine at 30-40 DEG C; performing forced circulation for 3.5 hours; filtering to obtain an alcohol extract; regulating the alcohol extract by using alcohol to enable the alcohol content of the alcohol extract to be 53-57 percent; and performing separate filling when the total content reaches 700 parts by weight to obtain the medicine composition for treating the traumatic injury.

Description

A kind of preparation method of pharmaceutical composition for the treatment of traumatic injury
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation thereof, preparation method, be specifically related to a kind of pharmaceutical composition for the treatment of traumatic injury and preparation thereof, preparation method, belong to pharmaceutical technology field.
Background technology
Acute soft tissue injury is orthopedics department commonly encountered diseases, frequently-occurring disease, belongs to the traditional Chinese medical science " injury of tendon and muscle " category, and clinical main manifestations is local swelling, pain, dysfunction, livid purple ecchymosis etc.Modern medicine has wrapping, partial closure, physical therapy etc. to the primary treatment method of acute soft tissue injury, and these method curative effects are not good enough, and rehabilitation duration is longer.The traditional Chinese medical science thinks that the main pathogenesis of acute soft tissue injury is that qi depression to blood stasis, venation are obstructed, in treatment, has unique advantage.
Summary of the invention
The object of the invention is to provide a kind of pharmaceutical composition and preparation thereof for the treatment of traumatic injury, and second object of the present invention is to provide the preparation method of this pharmaceutical composition,
The present invention seeks to be achieved through the following technical solutions.
The crude drug of pharmaceutical composition of the present invention consists of:
Radix Notoginseng 8-28 weight portion, Radix Angelicae Sinensis 4-14 weight portion, Myrrha 4-14 weight portion, Cortex Eucommiae 4-14 weight portion, Rhizoma Cibotii 4-14 weight portion, Herba Lycopi 4-14 weight portion, Rhizoma Et Radix Notopterygii 4-14 weight portion, Radix Angelicae Pubescentis 4-14 weight portion, Cortex Phellodendri 4-14 weight portion, Cortex erythrinae 4-14 weight portion, Olibanum (parched) 4-14 weight portion.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Radix Notoginseng 18 weight portions, Radix Angelicae Sinensis 9 weight portions, Myrrha 9 weight portions, the Cortex Eucommiae 9 weight portions, Rhizoma Cibotii 9 weight portions, Herba Lycopi's 9 weight portions, Rhizoma Et Radix Notopterygii 9 weight portions, Radix Angelicae Pubescentis 9 weight portions, Cortex Phellodendri 9 weight portions, Cortex erythrinae 9 weight portions, Olibanum (parched) 9 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Radix Notoginseng 10 weight portions, Radix Angelicae Sinensis 13 weight portions, Myrrha 5 weight portions, the Cortex Eucommiae 13 weight portions, Rhizoma Cibotii 5 weight portions, Herba Lycopi's 13 weight portions, Rhizoma Et Radix Notopterygii 5 weight portions, Radix Angelicae Pubescentis 13 weight portions, Cortex Phellodendri 5 weight portions, Cortex erythrinae 13 weight portions, Olibanum (parched) 5 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Radix Notoginseng 13 weight portions, Radix Angelicae Sinensis 11 weight portions, Myrrha 6 weight portions, the Cortex Eucommiae 11 weight portions, Rhizoma Cibotii 6 weight portions, Herba Lycopi's 11 weight portions, Rhizoma Et Radix Notopterygii 6 weight portions, Radix Angelicae Pubescentis 11 weight portions, Cortex Phellodendri 6 weight portions, Cortex erythrinae 11 weight portions, Olibanum (parched) 6 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Radix Notoginseng 16 weight portions, Radix Angelicae Sinensis 10 weight portions, Myrrha 8 weight portions, the Cortex Eucommiae 10 weight portions, Rhizoma Cibotii 8 weight portions, Herba Lycopi's 10 weight portions, Rhizoma Et Radix Notopterygii 8 weight portions, Radix Angelicae Pubescentis 10 weight portions, Cortex Phellodendri 8 weight portions, Cortex erythrinae 10 weight portions, Olibanum (parched) 8 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Radix Notoginseng 20 weight portions, Radix Angelicae Sinensis 8 weight portions, Myrrha 10 weight portions, the Cortex Eucommiae 8 weight portions, Rhizoma Cibotii 10 weight portions, Herba Lycopi's 8 weight portions, Rhizoma Et Radix Notopterygii 10 weight portions, Radix Angelicae Pubescentis 8 weight portions, Cortex Phellodendri 10 weight portions, Cortex erythrinae 8 weight portions, Olibanum (parched) 10 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Radix Notoginseng 23 weight portions, Radix Angelicae Sinensis 7 weight portions, Myrrha 11 weight portions, the Cortex Eucommiae 7 weight portions, Rhizoma Cibotii 11 weight portions, Herba Lycopi's 7 weight portions, Rhizoma Et Radix Notopterygii 11 weight portions, Radix Angelicae Pubescentis 7 weight portions, Cortex Phellodendri 11 weight portions, Cortex erythrinae 7 weight portions, Olibanum (parched) 11 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
Radix Notoginseng 26 weight portions, Radix Angelicae Sinensis 5 weight portions, Myrrha 13 weight portions, the Cortex Eucommiae 5 weight portions, Rhizoma Cibotii 13 weight portions, Herba Lycopi's 5 weight portions, Rhizoma Et Radix Notopterygii 13 weight portions, Radix Angelicae Pubescentis 5 weight portions, Cortex Phellodendri 13 weight portions, Cortex erythrinae 5 weight portions, Olibanum (parched) 13 weight portions.
Chinese medicine composition of the present invention adds conventional adjuvant, according to common process, makes clinical acceptable various preparations and includes but not limited to: external preparation is as aerosol, ointment, cataplasma, liniment, rubber-emplastrum, paste, liniment, transdermal patch etc.; Oral formulations is as powder, tablet, medicinal tea, hard capsule, soft capsule, drop pill, pill, honeyed pill, granule, soft extract with bee honey agent, medicated wine, oral liquid or ejection preparation and slow releasing preparation, controlled release preparation or quick releasing formulation etc.
The preparation method of Chinese medicine composition of the present invention comprises the steps:
Above 11 taste medical materials, mixed powder is broken into coarse powder, add behind 55% alcohol dipping 12-48 hour of 600 weight portions, it is 30 ℃~40 ℃ that medicine liquid heating is kept to fluid temperature, forced circulation 3.5 hours, filter, obtain alcohol extract, making alcohol extract contain alcohol amount with ethanol adjustment is 53%~57%, and total amount reaches 540 weight portions, subpackage, to obtain final product.
The sweet micro-bitter temperature of Radix Notoginseng in Chinese medicine composition composition formula of the present invention, removing stasis to stop bleeding, the analgesic therapy of invigorating blood circulation, is the key medicine of blood circulation promoting and blood stasis dispelling, therefore be monarch drug.Radix Angelicae Sinensis Gan Xinwen, enriches blood, invigorates blood circulation, and pain relieving, and make blood circulation promoting and blood stasis dispelling and non-blood trouble; Olibanum, the pain relieving of Myrrha blood-activating and qi-promoting, detumescence and promoting granulation, three medicines are ministerial drug altogether.Herba Lycopi's toil tepor, blood circulation promoting and blood stasis dispelling; The sweet temperature of the Cortex Eucommiae, invigorating the liver and kidney, bone and muscle strengthening; The bitter sweet temperature of Rhizoma Cibotii, wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint; Rhizoma Et Radix Notopterygii, the arduous temperature of Radix Angelicae Pubescentis, wind-damp dispelling, stopping numbness pain; Cortex erythrinae toil is flat, wind-damp dispelling, removing obstruction in the collateral to relieve pain; Cortex Phellodendri bitter cold, heat clearing and damp drying, eliminating fire and detoxication, is adjuvant drug.All medicines share, and play altogether the merit that blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral, hemostasis are cured the wound.Curing mainly various new and old soft tissue injurys, wound, scald, traumatic hemorrhage, Fengshi Guanjie swells and ache.
Following experimental example and embodiment are used for further illustrating but are not limited to the present invention.
experimental example 1 Chinese medicine composition clinical summary report of the present invention
1 physical data
Total case 60 examples, male 34 examples, female's 26 examples, 12~57 years old age, the course of disease 1 hour to 4 days.Wherein Ankle joint sprain and contusion 31 examples, shoulder joint bruise 12 examples, carpal joint bruise 17 examples.With reference to the diagnostic criteria about acute soft tissue injury in " new Chinese medicine guideline of clinical investigations ", make a definite diagnosis rear use Chinese medicine composition of the present invention (by embodiment 1 method preparation) and treat.
2 Therapeutic Method
Spraying affected part, gently rubs, and 3~4 times on the one 7 days is a course for the treatment of, after 1 course for the treatment of, judges curative effect.Inactive other drug during treatment.Coordinate and take medicine prepared by embodiment 10 if desired.
3 criterions of therapeutical effect
Judge with reference to the criterion of therapeutical effect in " new Chinese medicine guideline of clinical investigations ".Clinical cure: red, swollen, hot, pain disappears, and accompanying or adjacent joints activity freely; Effective: red, swollen, heat disappears, and slightly aches, accompanying or adjacent joints activity is substantially not limited; Effective: red, swollen, hot, alleviation of pain is light, accompanying or adjacent joints activity is slightly limited; Invalid: red, swollen, hot, pain nothing is improved, and joint motion is limited.
4 therapeutic outcomes
44 examples of fully recovering in 60 examples (73.3%), effective and effective 14 examples (23.3%), invalid 2 examples (3.3%), total effective rate 96.7%.
Following embodiment all can realize effect described in above-mentioned experimental example.
embodiment 1 tincture of the present invention
[formula]
Figure BDA00001765779700031
[method for making]
Above 11 taste medical materials, mixed powder is broken into coarse powder, add 55% alcohol dipping of 600kg after 24 hours, it is 30 ℃~40 ℃ that medicine liquid heating is kept to fluid temperature, forced circulation 3.5 hours, filter, obtain alcohol extract, making alcohol extract contain alcohol amount with ethanol adjustment is 53%~57%, and total amount reaches 540kg, subpackage, to obtain final product.
[usage and consumption]
Knife injury, wound, scald, get injured by a fall, hemorrhage: directly spray liquid medicine in wound, after marquis's liquid medicine absorbs, wrap up with clean gauze.Spray heals for several times.
Osteopatia sprain: directly spray liquid medicine in affected part, gently rub and be aided with massage with absorbent cotton.
Dissipating blood stasis for subsidence of swelling: ooze liquid medicine with absorbent cotton and again and again spread on affected part, when bruise pain is serious, the hot compress in addition of available heat water bag, alleviating pain and detumescence effect is better.
Arthralgia: ooze liquid medicine with absorbent cotton and spread on affected part.
embodiment 2 aerosol of the present invention
Radix Notoginseng 10kg, Radix Angelicae Sinensis 13kg, Myrrha 5kg, Cortex Eucommiae 13kg, Rhizoma Cibotii 5kg, Herba Lycopi 13kg, Rhizoma Et Radix Notopterygii 5kg, Radix Angelicae Pubescentis 13kg, Cortex Phellodendri 5kg, Cortex erythrinae 13kg, Olibanum (parched) 5kg.
Above 11 taste medical materials, mixed powder is broken into coarse powder, add 55% alcohol dipping of 600kg after 48 hours, it is 30 ℃~40 ℃ that medicine liquid heating is kept to fluid temperature, forced circulation 3.5 hours, filter, obtain alcohol extract, making alcohol extract contain alcohol amount with ethanol adjustment is 53%~57%, and total amount reaches 540kg, add conventional adjuvant, make aerosol.External.
embodiment 3 liniment of the present invention
Radix Notoginseng 13kg, Radix Angelicae Sinensis 11kg, Myrrha 6kg, Cortex Eucommiae 11kg, Rhizoma Cibotii 6kg, Herba Lycopi 11kg, Rhizoma Et Radix Notopterygii 6kg, Radix Angelicae Pubescentis 11kg, Cortex Phellodendri 6kg, Cortex erythrinae 11kg, Olibanum (parched) 6kg.
Above 11 taste medical materials, mixed powder is broken into coarse powder, add 55% alcohol dipping of 600kg after 12 hours, it is 30 ℃~40 ℃ that medicine liquid heating is kept to fluid temperature, forced circulation 3.5 hours, filter, obtain alcohol extract, making alcohol extract contain alcohol amount with ethanol adjustment is 53%~57%, and total amount reaches 540kg, add conventional adjuvant, make liniment.External.
embodiment 4 transdermal patch of the present invention
Radix Notoginseng 16kg, Radix Angelicae Sinensis 10kg, Myrrha 8kg, Cortex Eucommiae 10kg, Rhizoma Cibotii 8kg, Herba Lycopi 10kg, Rhizoma Et Radix Notopterygii 8kg, Radix Angelicae Pubescentis 10kg, Cortex Phellodendri 8kg, Cortex erythrinae 10kg, Olibanum (parched) 8kg.
Said medicine is added to conventional adjuvant, according to common process, make transdermal patch.
embodiment 5 medicated wine of the present invention
Radix Notoginseng 26kg, Radix Angelicae Sinensis 5kg, Myrrha 13kg, Cortex Eucommiae 5kg, Rhizoma Cibotii 13kg, Herba Lycopi 5kg, Rhizoma Et Radix Notopterygii 13kg, Radix Angelicae Pubescentis 5kg, Cortex Phellodendri 13kg, Cortex erythrinae 5kg, Olibanum (parched) 13kg.
Above medicine soaks 48 hours with yellow wine, removes slag and gets liquid, to obtain final product.For oral administration.
embodiment 6 powder of the present invention
Radix Notoginseng 10kg, Radix Angelicae Sinensis 13kg, Myrrha 5kg, Cortex Eucommiae 13kg, Rhizoma Cibotii 5kg, Herba Lycopi 13kg, Rhizoma Et Radix Notopterygii 5kg, Radix Angelicae Pubescentis 13kg, Cortex Phellodendri 5kg, Cortex erythrinae 13kg, Olibanum (parched) 5kg.
Said medicine is added to conventional adjuvant, according to common process, make powder.
embodiment 7 capsule of the present invention
Radix Notoginseng 13kg, Radix Angelicae Sinensis 11kg, Myrrha 6kg, Cortex Eucommiae 11kg, Rhizoma Cibotii 6kg, Herba Lycopi 11kg, Rhizoma Et Radix Notopterygii 6kg, Radix Angelicae Pubescentis 11kg, Cortex Phellodendri 6kg, Cortex erythrinae 11kg, Olibanum (parched) 6kg.
Said medicine is added to conventional adjuvant, according to common process, make capsule.
embodiment 8 honey pill agent of the present invention
Radix Notoginseng 16kg, Radix Angelicae Sinensis 10kg, Myrrha 8kg, Cortex Eucommiae 10kg, Rhizoma Cibotii 8kg, Herba Lycopi 10kg, Rhizoma Et Radix Notopterygii 8kg, Radix Angelicae Pubescentis 10kg, Cortex Phellodendri 8kg, Cortex erythrinae 10kg, Olibanum (parched) 8kg.
Said medicine is added to conventional adjuvant, according to common process, make honey pill agent.
embodiment 9 granule of the present invention
Radix Notoginseng 20kg, Radix Angelicae Sinensis 8kg, Myrrha 10kg, Cortex Eucommiae 8kg, Rhizoma Cibotii 10kg, Herba Lycopi 8kg, Rhizoma Et Radix Notopterygii 10kg, Radix Angelicae Pubescentis 8kg, Cortex Phellodendri 10kg, Cortex erythrinae 8kg, Olibanum (parched) 10kg.
Said medicine is added to conventional adjuvant, according to common process, granulation agent.
embodiment 10 oral liquid of the present invention
Radix Notoginseng 23kg, Radix Angelicae Sinensis 7kg, Myrrha 11kg, Cortex Eucommiae 7kg, Rhizoma Cibotii 11kg, Herba Lycopi 7kg, Rhizoma Et Radix Notopterygii 11kg, Radix Angelicae Pubescentis 7kg, Cortex Phellodendri 11kg, Cortex erythrinae 7kg, Olibanum (parched) 11kg.
Said medicine is added to conventional adjuvant, according to common process, make oral liquid.
embodiment 11 drop pill of the present invention
Radix Notoginseng 26kg, Radix Angelicae Sinensis 5kg, Myrrha 13kg, Cortex Eucommiae 5kg, Rhizoma Cibotii 13kg, Herba Lycopi 5kg, Rhizoma Et Radix Notopterygii 13kg, Radix Angelicae Pubescentis 5kg, Cortex Phellodendri 13kg, Cortex erythrinae 5kg, Olibanum (parched) 13kg.
Said medicine is added to conventional adjuvant, according to common process, make drop pill.

Claims (7)

1. treat the preparation method of the pharmaceutical composition of traumatic injury for one kind, it is characterized in that the method is: get crude drug, mixed powder is broken into coarse powder, add 55% alcohol dipping of 800 weight portions after 24 hours, it is 35 ℃ that medicine liquid heating is kept to fluid temperature, forced circulation 3.5 hours, filters, and obtains alcohol extract, making alcohol extract contain alcohol amount with ethanol adjustment is 55%, total amount reaches 700 weight portions, and subpackage to obtain final product;
Described crude drug consists of: Radix Notoginseng 8-28 weight portion, Radix Angelicae Sinensis 4-14 weight portion, Myrrha 4-14 weight portion, Cortex Eucommiae 4-14 weight portion, Rhizoma Cibotii 4-14 weight portion, Herba Lycopi 4-14 weight portion, Rhizoma Et Radix Notopterygii 4-14 weight portion, Radix Angelicae Pubescentis 4-14 weight portion, Cortex Phellodendri 4-14 weight portion, Cortex erythrinae 4-14 weight portion, Olibanum (parched) 4-14 weight portion.
2. the preparation method of pharmaceutical composition as claimed in claim 1, is characterized in that consisting of of described crude drug:
Radix Notoginseng 10 weight portions, Radix Angelicae Sinensis 13 weight portions, Myrrha 5 weight portions, the Cortex Eucommiae 13 weight portions, Rhizoma Cibotii 5 weight portions, Herba Lycopi's 13 weight portions, Rhizoma Et Radix Notopterygii 5 weight portions, Radix Angelicae Pubescentis 13 weight portions, Cortex Phellodendri 5 weight portions, Cortex erythrinae 13 weight portions, Olibanum (parched) 5 weight portions.
3. the preparation method of pharmaceutical composition as claimed in claim 1, is characterized in that consisting of of described crude drug:
Radix Notoginseng 13 weight portions, Radix Angelicae Sinensis 11 weight portions, Myrrha 6 weight portions, the Cortex Eucommiae 11 weight portions, Rhizoma Cibotii 6 weight portions, Herba Lycopi's 11 weight portions, Rhizoma Et Radix Notopterygii 6 weight portions, Radix Angelicae Pubescentis 11 weight portions, Cortex Phellodendri 6 weight portions, Cortex erythrinae 11 weight portions, Olibanum (parched) 6 weight portions.
4. the preparation method of pharmaceutical composition as claimed in claim 1, is characterized in that consisting of of described crude drug:
Radix Notoginseng 16 weight portions, Radix Angelicae Sinensis 10 weight portions, Myrrha 8 weight portions, the Cortex Eucommiae 10 weight portions, Rhizoma Cibotii 8 weight portions, Herba Lycopi's 10 weight portions, Rhizoma Et Radix Notopterygii 8 weight portions, Radix Angelicae Pubescentis 10 weight portions, Cortex Phellodendri 8 weight portions, Cortex erythrinae 10 weight portions, Olibanum (parched) 8 weight portions.
5. the preparation method of pharmaceutical composition as claimed in claim 1, is characterized in that consisting of of described crude drug:
Radix Notoginseng 20 weight portions, Radix Angelicae Sinensis 8 weight portions, Myrrha 10 weight portions, the Cortex Eucommiae 8 weight portions, Rhizoma Cibotii 10 weight portions, Herba Lycopi's 8 weight portions, Rhizoma Et Radix Notopterygii 10 weight portions, Radix Angelicae Pubescentis 8 weight portions, Cortex Phellodendri 10 weight portions, Cortex erythrinae 8 weight portions, Olibanum (parched) 10 weight portions.
6. the preparation method of pharmaceutical composition as claimed in claim 1, is characterized in that consisting of of described crude drug:
Radix Notoginseng 23 weight portions, Radix Angelicae Sinensis 7 weight portions, Myrrha 11 weight portions, the Cortex Eucommiae 7 weight portions, Rhizoma Cibotii 11 weight portions, Herba Lycopi's 7 weight portions, Rhizoma Et Radix Notopterygii 11 weight portions, Radix Angelicae Pubescentis 7 weight portions, Cortex Phellodendri 11 weight portions, Cortex erythrinae 7 weight portions, Olibanum (parched) 11 weight portions.
7. the preparation method of pharmaceutical composition as claimed in claim 1, is characterized in that consisting of of described crude drug:
Radix Notoginseng 26 weight portions, Radix Angelicae Sinensis 5 weight portions, Myrrha 13 weight portions, the Cortex Eucommiae 5 weight portions, Rhizoma Cibotii 13 weight portions, Herba Lycopi's 5 weight portions, Rhizoma Et Radix Notopterygii 13 weight portions, Radix Angelicae Pubescentis 5 weight portions, Cortex Phellodendri 13 weight portions, Cortex erythrinae 5 weight portions, Olibanum (parched) 13 weight portions.
CN201210197567.3A 2012-06-14 2012-06-14 Preparation method for medicine composition for treating traumatic injury Active CN102697928B (en)

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