CN109758557A - Treat enteroparalysis and seroperitoneum Chinese medicine composition and dissipate-swelling cream/dissipate - Google Patents

Abstract

The present invention provides the Chinese medicine compositions for the treatment of enteroparalysis and seroperitoneum, its formula is as follows: 10~20 parts of trigone, 15~25 parts of curcuma zedoary, 10~20 parts of Cortex Magnoliae Officinalis, 20~40 parts of saltcake, 20~40 parts of radish seed, 20~40 parts of castor bean, 15~25 parts of the root of gansui, 20~30 parts of peppermint, 5~20 parts of Chinese prickly ash, 5~20 parts of agalloch eaglewood, 20~40 parts of turpentine；The formula of the invention is reasonable, has the function of promoting the circulation of qi promoting, heat and toxic materials clearing away, broken knot stagnation resolvation, significant in efficacy for treating enteroparalysis and seroperitoneum, can more effectively improve enteroparalysis, promote restoration of gastrointestinal function, can promote the recovery of seroperitoneum absorption enhancement disease；Active drug component content is high, stablizes without obvious toxic-side effects, effect, is easy to use.

Description

Treat enteroparalysis and seroperitoneum Chinese medicine composition and dissipate-swelling cream/dissipate

(1) technical field

The present invention relates to a kind of Chinese medicine composition for treating enteroparalysis and seroperitoneum and its applications, and utilize the Chinese medicine The Chinese medicinal ointment and powder of composition preparation.

(2) background technique

Enteroparalysis, also known as unpowered property enteroparalysis, paralytic ileus are because a variety of causes influences enteron aisle vegetative nerve The balance of system, or the conduction of enteron aisle local nerve is influenced, or the contraction of influence intestinal smooth makes dilatation of intestine, loss of peristalsis, Intestinal contents cannot be pushed forward and cause intestinal dysfunction.Seroperitoneum refers under any pathological state, intraperitoneal liquid The scale of construction increases above 200ml.Enteroparalysis and seroperitoneum see various clinical disease, and it is comprehensive that serious person can lead to abdominal compartment Sign causes multiple organ dysfunction, or even dead.Enteroparalysis and seroperitoneum belong to Chinese medicine abdominal pain, bulging etc., the interpretation of the cause, onset and process of an illness develop with Phlegm-blood stasis retardance, FU QI being obstructed, based on fluid metabolism mistake department.Traditional Chinese medicine, combined therapy of Chinese and Western medicine treatment enteroparalysis and abdominal cavity product Liquid can be absorbed by inhibiting inflammatory factor release, improving microcirculation, adjusting fluid metabolism, promotion enterocinesia recovery and seroperitoneum Equal multiple target points, too many levels play curative effect, shorten the course of disease, reduce complication, improve cure rate, have been clinical practice card It is bright, obtain clinical extensive approval.

(3) summary of the invention

It is an object of the present invention to provide one kind have definite curative effect, without obvious toxic-side effects, effect stabilization, easy to use control Chinese medicine composition and its application of enteroparalysis and seroperitoneum are treated, and utilizes the Chinese medicinal ointment of Chinese medicine composition preparation and dissipates Agent.

The technical solution adopted by the present invention is that:

A kind of Chinese medicine composition for treating enteroparalysis and seroperitoneum is made of: three the following Chinese medicine material of quality proportioning 10~20 parts of rib, 15~25 parts of curcuma zedoary, 10~20 parts of Cortex Magnoliae Officinalis, 20~40 parts of saltcake, 20~40 parts of radish seed, castor bean 20~40 Part, 15~25 parts of the root of gansui, 20~30 parts of peppermint, 5~20 parts of Chinese prickly ash, 5~20 parts of agalloch eaglewood, 20~40 parts of turpentine.As needed, institute Proper honey can also be added by stating in formula.

The composition material quality composition is as follows: 15 parts of trigone, 20 parts of curcuma zedoary, and 15 parts of Cortex Magnoliae Officinalis, 30 parts of saltcake, radish seed 30 parts, 30 parts of castor bean, 20 parts of the root of gansui, 25 parts of peppermint, 10 parts of Chinese prickly ash, 10 parts of agalloch eaglewood, 30 parts of turpentine.

Wherein, all medicines of trigone, Cortex Magnoliae Officinalis, radish seed, peppermint, Chinese prickly ash, agalloch eaglewood, turpentine, curcuma zedoary are pungent opens bitter drop, and hardship can descend gas, It is pungent can dissipating bind, temperature can eliminating dampness have a drastically removing blood stasis and resolving static blood, clearing stagnation and killing pain, kind except stagnant gas in stomach, dry spleen man is wet strongly fragrant, thus can under it is tangible real It is full, and invisible abdominal distention can be dissipated；Saltcake, castor bean, the root of gansui can rush down stomach real heat, moistening for dryness and softening hard mass.By the water between intestines: being used for Dragging pain between the chest and hypochondrium, epigastric fullness and rigidity, abdominal fullness and distention.Modern pharmacological research confirms: castor bean, saltcake have effects that promote enterocinesia castor Numb enuatrol is irritant to small intestine, and enterocinesia is caused to enhance, and small intestine contents are rapidly promoted to colon, and enteron aisle is made to keep a large amount of Moisture expands enteron aisle, causes enterocinesia enhancing and defecation；Moreover, trigone, curcuma zedoary, turpentine, peppermint are rich in volatile oil, have and promote Promote drug external application that can play therapeutic effect into Drug Percutaneous Absorption, peak honey is as excipients.Under full side plays promoting the circulation of qi promoting altogether, rushes down Attack the function of product, broken knot stagnation resolvation.

The invention further relates to application of the Chinese medicine composition in the drug of preparation treatment enteroparalysis.

The invention further relates to application of the Chinese medicine composition in the drug of preparation treatment seroperitoneum.

A kind of Chinese medicinal ointment for treating enteroparalysis and seroperitoneum, the Chinese medicinal ointment are former by the following Chinese medicine of quality proportioning Material is made: 10~20 parts of trigone, 15~25 parts of curcuma zedoary, and 10~20 parts of Cortex Magnoliae Officinalis, 20~40 parts of saltcake, 20~40 parts of radish seed, castor 20~40 parts of pockmarks, 15~25 parts of the root of gansui, 20~30 parts of peppermint, 5~20 parts of Chinese prickly ash, 5~20 parts of agalloch eaglewood, 20~40 parts of turpentine, Appropriate honey；The Chinese medicinal ointment the preparation method is as follows:

(1) raw material that formula ratio is weighed according to Chinese medicine composition composition, the raw material other than saltcake, honey is cleaned, spare；

(2) saltcake except in step (1) and the raw material other than honey are soaked in water, water buried 1~2cm of powder, impregnated Afterwards, decocting is extracted 2 times；It is first cooked by slow fire to medicine for 1st time and sufficiently to expand, boil again, boiling 15~30 minutes is kept, by dregs of a decoction mistake Filter, obtains the 1st decoction；The filtering gained dregs of a decoction, the 2nd time plus water, water buried 1~2cm of powder, be cooked by slow fire to medicine sufficiently expand, It boils again and keeps boiling 15~30 minutes, the dregs of a decoction are filtered, obtain the 2nd decoction；2 decoctions are mixed, are continued with being cooked by slow fire When three point one or so surplus to moisture evaporation, proper honey is added, continues mild fire heating, constantly stirs to being concentrated into paste (to be in " hang flag " shape or take cream drop on mulberry paper, the not permeable washmarking of surrounding be degree), saltcake is added when being cooled to 40~60 DEG C, stirring is extremely Saltcake is completely dissolved in ointment；

(3) ointment obtained by step (2) is dispensed with Chinese medicine special herbal paste porcelain jar or stainless cylinder of steel, after ointment is sufficiently let cool It covers, seals cryo-conservation to get the Chinese medicinal ointment.

Preferably, the Chinese medicinal ointment is made of the following Chinese medicine material of quality proportioning: 15 parts of trigone, 20 parts of curcuma zedoary, thick 15 parts of Piao, 30 parts of saltcake, 30 parts of radish seed, 30 parts of castor bean, 20 parts of the root of gansui, 25 parts of peppermint, 10 parts of Chinese prickly ash, 10 parts of agalloch eaglewood, pine 30 parts of section, appropriate honey.

A kind of traditional Chinese powder medicine for treating enteroparalysis and seroperitoneum, the traditional Chinese powder medicine are former by the following Chinese medicine of quality proportioning Material is made: 10~20 parts of trigone, 15~25 parts of curcuma zedoary, and 10~20 parts of Cortex Magnoliae Officinalis, 20~40 parts of saltcake, 20~40 parts of radish seed, castor 20~40 parts of pockmarks, 15~25 parts of the root of gansui, 20~30 parts of peppermint, 5~20 parts of Chinese prickly ash, 5~20 parts of agalloch eaglewood, 20~40 parts of turpentine； The traditional Chinese powder medicine the preparation method is as follows:

(1) Chinese medicine material that formula ratio is weighed according to Chinese medicine composition composition, by trigone, curcuma zedoary, Cortex Magnoliae Officinalis, saltcake, radish The 11 taste medicine such as son, castor bean, the root of gansui, peppermint, Chinese prickly ash, agalloch eaglewood, turpentine is ground into as 100~200 mesh fine powders, spare；

(2) fine powder for obtaining step (1), the inner wrapping of every bag of 30g is distributed into tulle bag, close with polybag vacuum Envelope is to get the traditional Chinese powder medicine.

Preferably, the traditional Chinese powder medicine is made of the following Chinese medicine material of quality proportioning: 15 parts of trigone, 20 parts of curcuma zedoary, thick 15 parts of Piao, 30 parts of saltcake, 30 parts of radish seed, 30 parts of castor bean, 20 parts of the root of gansui, 25 parts of peppermint, 10 parts of Chinese prickly ash, 10 parts of agalloch eaglewood, pine 30 parts of section.

Dissipate-swelling cream/dissipate is national base's distinguished veteran doctors of TCM medicine expert, batch old docter of TCM expert's academic heritage work of Fujian Province's third Counselor's Guo Senren chief physician's Empirical formula, with promoting the circulation of qi promoting, heat and toxic materials clearing away, broken knot stagnation resolvation function, for enteroparalysis and Seroperitoneum has preferable clinical efficacy.

The beneficial effects are mainly reflected as follows: (1) the formula of the invention is reasonable, has promoting the circulation of qi promoting, heat and toxic materials clearing away, breaks The effect for tying stagnation resolvation, can effectively treat enteroparalysis and seroperitoneum.(2) present invention has active drug component content height, without bright The advantages that aobvious toxic side effect, effect stablize, are easy to use, makes paste making agent or powder, can be with convenient for storage, when clinical application When take, more meet clinical practice.(3) present invention passes through the clinical application of Chinese medicinal ointment and powder, inflammatory factor is inhibited to discharge, Improve microcirculation, adjust fluid metabolism, enterocinesia recovery and seroperitoneum is promoted to absorb, shortens the course of disease, promote the recovery of disease, Adverse reaction rate is reduced, the special advantage effect of traditional Chinese medicine has been given full play to.

(4) specific embodiment

The present invention is described further combined with specific embodiments below, but protection scope of the present invention is not limited in This:

Embodiment 1: dissipate-swelling cream preparation

Composition of raw materials: 15 parts of trigone, 20 parts of curcuma zedoary, 15 parts of Cortex Magnoliae Officinalis, 30 parts of saltcake, 30 parts of radish seed, 30 parts of castor bean, sweet Then 20 parts, 25 parts of peppermint, 10 parts of Chinese prickly ash, 10 parts of agalloch eaglewood, 30 parts of turpentine, appropriate honey.

Preparation method:

(1) raw material that formula ratio is weighed according to Chinese medicine composition composition, the raw material other than saltcake, honey is cleaned, spare；

(2) saltcake except in step (1) and the raw material other than honey are soaked in water, water buried powder about 2cm, impregnated Afterwards, decocting is extracted 2 times；It is first cooked by slow fire to medicine for 1st time and sufficiently to expand, boil again, keep boiling 25 minutes, the dregs of a decoction are filtered, Obtain the 1st decoction；The filtering gained dregs of a decoction, the 2nd time plus water, water buried powder about 2cm, and were cooked by slow fire to medicine and sufficiently expand, boil again Boiling 20 minutes is boiled and kept, the dregs of a decoction are filtered, the 2nd decoction is obtained；2 decoctions are mixed, are continued with being cooked by slow fire to moisture steaming When hair is three point one or so surplus, proper honey is added, continues mild fire heating, constantly stirs to being concentrated into " hanging flag " shape (or take cream Drip on mulberry paper, the not permeable washmarking of surrounding be degree), be added saltcake when being cooled to about 50 DEG C, stirring to saltcake is completely dissolved in medicine In cream；

(3) ointment obtained by step (2) is dispensed with Chinese medicine special herbal paste porcelain jar or stainless cylinder of steel, after ointment is sufficiently let cool It covers, seals cryo-conservation to get the Chinese medicinal ointment.Face the used time, by ointment divide on gauze, put in micro-wave oven suitably plus After heat, it is externally applied to patients abdomen.

Embodiment 2: dissipate-swelling dissipates preparation

Composition of raw materials: 15 parts of trigone, 20 parts of curcuma zedoary, 15 parts of Cortex Magnoliae Officinalis, 30 parts of saltcake, 30 parts of radish seed, 30 parts of castor bean, 20 parts of the root of gansui, 25 parts of peppermint, 10 parts of Chinese prickly ash, 10 parts of agalloch eaglewood, 30 parts of turpentine.

Preparation method:

(1) raw material that formula ratio is weighed according to Chinese medicine composition composition, by trigone, curcuma zedoary, Cortex Magnoliae Officinalis, saltcake, radish seed, castor The 11 taste medicine such as pockmarks, the root of gansui, peppermint, Chinese prickly ash, agalloch eaglewood, turpentine is ground into impalpable powder (about 100 mesh), spare.

(2) by the raw material in step (1), the inner wrapping of every bag of 30g is distributed into tulle bag, with polybag vacuum sealing, It is spare.Face the used time, according to patients abdomen skin area, if dry bag medicine is taken to dissipate, removes outer layer plastic vacuum-packaging bag, be externally applied to disease People's abdomen.

Embodiment 3: dissipate-swelling cream treats the raised clinical research of acute pancreatitis intra-abdominal pressure

1. research purpose:

It observes dissipate-swelling cream (preparation of embodiment 1) and treats the raised clinical efficacy of acute pancreatitis intra-abdominal pressure.

2. research object and method

2.1 research object

60 acute pancreatitis of in January, 2016 institute of traditional Chinese medicine, Jinjiang City, Fujian Province's in December, -2017 treatment are included in in abdomen Pressure increases patient: (1) meeting Chinese Medical Association's disease for digest credit can pancreatic disease group " Chinese acute pancreatitis diagnosis and treatment guide (2013, Shanghai) " and the spleen-stomach diseases branch, China Association of Traditional Chinese Medicine " Severe Acute Pancreatitis SAP combination of Chinese tradiational and Western medicine diagnosis and treatment routine (2013) " in dependent diagnostic standard；(2) merge intra-abdominal pressure to increase, intra-abdominal pressure >=12mmHg.

It is divided into control group and each 30 for the treatment of group according to random digits table.Treatment group male 21, female 9；Age 41- 60 years old, average (47.5 ± 3.6) year；Acute physiology and chronic healthy grade form (APACHE II) scoring it is average (16.04 ± 2.41) point；Consultation time (16.28 ± 6.45) h.Control group male 20, female 10；Age 40-59 years old, average (48.1 ± 3.7) year；APACHE II scores average (16.01 ± 2.38) point；Consultation time (16.31 ± 6.41) h.2 groups of genders, the age, The data such as the scoring of APACHE II compare, and difference is not statistically significant (P > 0.05), is comparable.

2.2 treatment method

Control group gives doctor trained in Western medicine bundling treatment, fasting immediately, gastrointestinal decompression, analgesic, spasmolysis, restricted liquid after being admitted to hospital Recovery and Hemorrhagic shock inhibit pancreatin secretion, maintain electrolyte and acid-base balance, dredging enteron aisle and early stage EN support, suppression Important organs function-stables such as systemic inflammatory response syndrome processed, prevention and treatment infection, maintenance cardiopulmonary kidney etc., blood purification is controlled when necessary It treats.

Treatment group adds on the basis of doctor trained in Western medicine bundling treatment uses the full abdomen external application of dissipate-swelling cream.

Whole nation base, dissipate-swelling cream system distinguished veteran doctors of TCM medicine expert, Fujian Province's third batch old docter of TCM expert's academic heritage job guide Teacher's Guo Senren chief physician's Empirical formula, with promoting the circulation of qi promoting, heat and toxic materials clearing away, broken knot stagnation resolvation function, by trigone, curcuma zedoary, Cortex Magnoliae Officinalis, The 12 taste Chinese medicinal composition such as saltcake, radish seed is supplied by Preparation Room in Hospital is unified, traditional Chinese medicinal ointment is made in the related prepared slices of Chinese crude drugs in advance Agent is dispensed with Chinese medicine special herbal paste porcelain jar or stainless cylinder of steel, sealing cryo-conservation, spare.Face the used time, ointment is divided in gauze On, it puts after suitably being heated in micro-wave oven, is externally applied to patients abdomen, fixed with waterproof medical treatment pad/diaper covering；Periodic replacement Ointment (is replaced 1 time) for every eight hours, and ointment water suction is thinning, is impregnated with treatment pad, diaper then replaces ointment, it is not necessary to stick to 8 hours again Replacement.It is increased if performance disappears if intra-abdominal pressures such as patient's abdominal distension, abdominal pain, seroperitoneums and stops being applied with.

2.3 observation index

It records 2 groups of patients and treats 1,7,14 day abdominal distension integral and intra-abdominal pressure after preceding and treatment；Record 2 groups of patient anus rows Gas/defecation time and gurgling sound recovery time, seroperitoneum extinction time, adverse reaction situation.

Intra-abdominal pressure is using bladder pressure measurement: Foley catheter is inserted by patient lies supine through patient's urethra, bladder, empties wing After Guang, sterile saline 20ml is injected through urinary catheter, connects pressure gauge, using pubic symphysis as zero point, the pressure measured is wing Guang pressure (intra-abdominal pressure).

Abdominal distension integral is evaluated referring to Standards for Diagnosis and Curative Effect of Chinese Medical Symptom.0 point: abdominal B-scan ultrasonography prompts enteron aisle without pneumatosis；1 point: Abdomen slightly bulge presses softer, a small amount of pneumatosis/hydrops of B ultrasound prompt；2 points: abdominal distention presses slightly hard, equivalance in B ultrasound prompt Gas/hydrops；3 points: abdomen such as drum, pressing is harder, and B ultrasound prompts a large amount of pneumatosis and intestinal tube is obviously expanded or intraperitoneal a large amount of hydrops.

2.4 statistical procedures

Statistical analysis is carried out to above-mentioned data using 22 statistical software of SPSS, measurement data is using variance analysis, counting Data uses rank sum test using Chi-square Test, ranked data, is judged as poor with statistics according to P < 0.05 or P < 0.01 It is different.

3 results

The pretherapy and post-treatment abdominal distension integral of 3.1 2 groups of patients, intra-abdominal pressure are relatively shown in Table 1.

Before treatment, 2 groups of patient's abdominal distension integrals, intra-abdominal pressures compare, and difference is not statistically significant (P > 0.05)；2 groups of patients The abdominal distension treated rear 1,7,14 day integrates, intra-abdominal pressure is obviously improved before relatively treating, and treatment group's improvement is significant compared with control group, poor Different statistically significant (P < 0.05).

The pretherapy and post-treatment abdominal distension integral intra-abdominal pressure of table 1:2 group patient compares

Compared with before treatment, P < 0.05 *；Compared with the control group same period, #P < 0.05

3.2 2 groups of patient anus exhaust/defecation recovery times, gurgling sound recovery time, seroperitoneum extinction times compare It is shown in Table 2.

Treatment group's passage of gas by anus/defecation recovery time, gurgling sound recovery time, seroperitoneum extinction time shorter than compare Group, difference are statistically significant (P < 0.05).

Table 22 groups of patient anus exhaust/defecation recovery times, gurgling sound recovery time, seroperitoneum extinction times compare

3.3 adverse reaction

2 groups of patients are showed no obvious adverse reaction during treatment.

4. discussing

Clinically, often there is the raising performance of the intra-abdominal pressures such as abdominal distension, abdominal pain, seroperitoneum in acute pancreatitis.Its main cause It is enteroparalysis caused by pancreas inflammatory exudation and inflammatory reaction.Enterocinesia inhibition will will lead to intestinal contents stagnation, finally make thin Bacterium excessive multiplication, growth, while it also increases stimulation intestinal secretion, increases enteral pressure, destroys gut barrier effect.

Tcm theory thinks that acute pancreatitis belongs to scopes such as " abdominal pain " " splenic precordial pain " " the spleen-warm syndromes ", and the state of an illness is complicated, with The stagnation of the circulation of vital energy, blood stasis, dampness, heat knot, poison accumulate and folder or based on mutually converting, mostly simulataneous insufficiency and excessive, asthenia in origin and asthenia in superficiality card.The rules for the treatment of are to manage Gas clearing damp, dredging intestines, activating microcirculation and removing stasis medicinal, it is clearing heat and detoxicating be method.Dissipate-swelling cream used in this research, trigone therein, Cortex Magnoliae Officinalis, radish The all medicines of son, peppermint, Chinese prickly ash, agalloch eaglewood, turpentine, curcuma zedoary are pungent to open bitter drop, and hardship can descend gas, pungent energy dissipating bind, and temperature energy eliminating dampness has drastically removing blood stasis and resolving static blood, Clearing stagnation and killing pain, kind except stagnant gas in stomach, dry spleen man is wet strongly fragrant, thus can under tangible reality expire and dissipate invisible abdominal distention；Awns Nitre, castor bean, the root of gansui can rush down stomach real heat, and moistening for dryness and softening hard mass, by the water between intestines: for dragging pain between the chest and hypochondrium, epigastric fullness and rigidity, stomach duct and abdomen is swollen It is full.Modern pharmacological research confirms: castor bean, saltcake have effects that promotion enterocinesia sodium ricinoleate is irritant to small intestine, Enterocinesia is caused to enhance, small intestine contents rapidly promote to promote defecation to colon, there can be temporary constipation in intestines after defecation Hypertonic salting liquid is formed after being inside dissolved in water.Thus make enteron aisle keep large quantity of moisture, expand enteron aisle, cause enterocinesia enhance and Defecation has and Drug Percutaneous Absorption is promoted to promote drug external application that can rise moreover, trigone, curcuma zedoary, turpentine, peppermint are rich in volatile oil To therapeutic effect；Peak honey is as excipients.Promoting the circulation of qi promoting, heat and toxic materials clearing away, the broken function for tying stagnation resolvation are played altogether in full side.

Above-mentioned clinical research discovery, 1,7,14 day abdominal distension integral, intra-abdominal pressure are obvious before relatively treating after 2 groups of patient's treatments Improve (P < 0.05), and treatment group improves compared with control group significantly (P < 0.05).Treatment group's passage of gas by anus/defecation recovery time, intestines Sound recovery time, seroperitoneum extinction time ring shorter than control group (P < 0.05).Illustrate on basis of conventional therapy plus with disappearing The swollen full abdomen external application treatment acute pancreatitis intra-abdominal pressure of cream increases, and can improve enterocinesia, seroperitoneum is promoted to absorb, to reduce Intra-abdominal pressure has good clinical efficacy.In addition, patient is showed no obvious adverse reaction during treatment, it is certain to illustrate that the therapy has Safety.

5. conclusion

The above clinical research shows that the external application Chinese medicine paste (dissipate-swelling cream) of Chinese medicine composition preparation of the present invention is controlled It treats acute pancreatitis intra-abdominal pressure to increase, can more effectively improve the clinical symptoms such as patient's abdominal distension, abdominal pain, ascites, adjust body aqueous Metabolism promotes enterocinesia recovery and seroperitoneum to subside, shortens the course of disease, promote the recovery of disease.

Embodiment 4: dissipate-swelling dissipates the clinical research for the treatment of abdomen pelvic part Postoperative enteroparalysis

1. research purpose:

Observe the clinical efficacy that dissipate-swelling dissipates (preparation of embodiment 2) treatment abdomen pelvic part Postoperative enteroparalysis.

2. research data and method

2.1 general information

Select during in September, 2016-in September, 2017 institute of traditional Chinese medicine, Jinjiang City, Fujian Province go to a doctor 150 receive abdomen pelvic part The patient of operation is as research object, wherein male 81, female 69, the 32-69 years old age (45.82 ± 6.28) year.All patients Made a definite diagnosis according to corresponding symptom, sign combination auxiliary examination, admitting to hospital after clear surgical indication carries out abdomen pelvic part operation.Its In, gynecological surgery 19, obstetric operation 17, gastrointestinal surgery 46, liver and gallbladder pancreas spleen surgical operation 52, Urology Surgery hand Art 16.

2.2 group technology

150 patients are randomly divided into observation group and control group.It is control group 75, postoperative to give at abdomen pelvic part operation routine Reason, wherein male 28, female 22, the 33-68 years old age (46.13 ± 6.33) year；Observation group 75, it is postoperative to give dissipate-swelling and dissipate full abdomen Portion be applied with, wherein male 27, female 23, the age 33-69 years old, the age average (45.73 ± 6.11) year.2 groups of Genders, years The no difference of science of statistics (P > 0.05) such as age, the course of disease, systemic conditions, is comparable.

2.3 dissipate-swellings dissipate full abdomen external application method

It is national base distinguished veteran doctors of TCM medicine expert, Fujian Province's third batch old docter of TCM expert's academic heritage job guide that dissipate-swelling, which dissipates, Teacher's Guo Senren chief physician's Empirical formula, with promoting the circulation of qi promoting, heat and toxic materials clearing away, broken knot stagnation resolvation function, by trigone, curcuma zedoary, Cortex Magnoliae Officinalis, The 11 taste Chinese medicinal composition such as saltcake, radish seed is supplied by Preparation Room in Hospital is unified, is in advance ground into the related prepared slices of Chinese crude drugs superfine Powder is distributed into the inner wrapping of every bag of 30g with tulle bag, spare with polybag vacuum sealing.In 24-48 hours postoperative, excluding In abdomen pelvic cavity after active hemorrhage, according to patients abdomen skin area, if dry bag medicine is taken to dissipate, removal outer layer vacuum plastic packaging Bag is externally applied to the full abdomen of patient (under xiphoid-process, down toward pubic symphysis, left and right to bilateral anterior axillary line), notices that avoiding operation cuts Mouth is simultaneously properly fixed with medical adhesive tape.External application scheme, medicine are adjusted according to patient anus exhaust/defecation, gurgling sound and abdominal distension symptom Medicinal powder is hardened then more medicine dressing change bag in bag.If postoperative anal exhaust/defecation, abdominal distension disappearance stops being applied with.

2.4 observation index

Observe 2 groups of patient's postoperative abdominal distention duration, Incision drain amount, passage of gas by anus/defecation recovery time and postoperative Bed rest time.

2.5 statistical method

Statistical analysis is carried out to above-mentioned data using 22 software of SPSS, measurement data uses variance analysis, enumeration data Using Chi-square Test, it is judged as according to P < 0.05 with statistical difference.

3. result

2 groups of patient's postoperative abdominal distention duration, Incision drain amount, passage of gas by anus/defecation recovery time and postoperative bed Time is control group>observation group (P<0.05).

Two groups of patient's enteroparalysis remission times compare

4. discussing

Clinically, it needs to perform the operation by abdomen pelvic part there are many disease to solve.Various operations in operation can pull abdomen basin Intracavitary correlation internal organs, the nerve for destroying normal anatomy relationship, damaged portion domination gastrointestinal smooth muscle, lead to postoperative patient stomach There is enteroparalysis symptom in intestines peristalsis miopragia；Further, since peri-operation period loses big quantity of fluid, electrolyte disturbance, postoperative Incision pain, abdominal reflexes weaken, and enteroparalysis can also be further aggravated.Wherein, abdominal distension directly reacts the wriggling situation of gastrointestinal tract, Promote the recovery of enterocinesia that there is positive meaning for the recovery of the postoperative state of an illness using effective measures.Postoperative gastrointestinal peristalsis function It can restore to cause Postoperative enteroparalysis in time, abdominal distension, the symptom of abdominal pain and water and electrolyte disorder can be further aggravated, even There is paralytic ileus, intestinal adhesion, seriously affects the curative effect of prognosis and the operation of disease.

According to theory of traditional Chinese medical science, Postoperative enteroparalysis is due to internal organs stagnation of QI-blood, imbalance of yin and yang, conduction transporting fortune function Can be impaired caused, show as the TCM syndromes such as phlegm-blood stasis retardance, FU QI being obstructed, fluid metabolism mistake department.In peri-operation period, using tool Have that the Chinese medicine of the effect of promoting the circulation of qi promoting, heat and toxic materials clearing away, broken knot stagnation resolvation can preferably alleviate enteroparalysis.During dissipate-swelling dissipates, trigone, thickness Piao, radish seed, peppermint, Chinese prickly ash, agalloch eaglewood, turpentine, all medicines of curcuma zedoary be pungent to open bitter drop, and hardship can descend gas, it is pungent can dissipating bind, temperature can eliminating dampness have it is broken Stasis and resolving masses, clearing stagnation and killing pain, kind except stagnant gas in stomach, dry spleen man is wet strongly fragrant, thus can under tangible reality expire and to dissipate invisible stomach duct and abdomen swollen Bitterly；Saltcake, castor bean, the root of gansui can rush down stomach real heat, moistening for dryness and softening hard mass.By the water between intestines: being used for dragging pain between the chest and hypochondrium, epigastric fullness and rigidity, gastral cavity Distention and fullness in the abdomen.Modern pharmacological research confirms: castor bean, saltcake have effects that promote enterocinesia sodium ricinoleate irritating to small intestine Property, cause enterocinesia to enhance, small intestine contents rapidly promote to promote defecation to colon, there can be temporary constipation to exist after defecation Enteral forms hypertonic salting liquid after being dissolved in water.So that enteron aisle is kept large quantity of moisture, expands enteron aisle, enterocinesia is caused to enhance And defecation has and Drug Percutaneous Absorption is promoted to promote drug external application energy moreover, trigone, curcuma zedoary, turpentine, peppermint are rich in volatile oil Play therapeutic effect.Dissipate-swelling is dissipated in the studies above and is externally applied to full abdomen, by the efficacy of a drug of body temperature heat, is acted on by skin Body, drug can enter stomach, large intestine, tri-jiao channel, play the role of promoting the circulation of qi promoting, heat and toxic materials clearing away, broken knot stagnation resolvation.

In the studies above, the patient of full abdomen external application is dissipated using dissipate-swelling and not using the scattered trouble being applied with of dissipate-swelling by comparing Person's Postoperative enteroparalysis recovery situation is it is found that dissipating control group patient's postoperative abdominal distention duration of full abdomen external application using dissipate-swelling, cutting Mouth drainage flow, passage of gas by anus/defecation recovery time and postoperative bedrest are significantly shorter than observation group.This just illustrates abdomen pelvic part Dissipating full abdomen external application using dissipate-swelling after operation helps to improve Postoperative enteroparalysis, has positive therapeutic potential.

5. conclusion

The above clinical research shows that the external traditional Chinese medicine powder (dissipate-swelling dissipates) of Chinese medicine composition preparation of the present invention is controlled Abdomen pelvic part Postoperative enteroparalysis is treated, Postoperative enteroparalysis can be more effectively improved, promotes restoration of gastrointestinal function, adjusts body fluid metabolism, Promote postoperative Analyze to absorb, shortens the course of disease, promote the recovery of disease.

Claims (8)

1. a kind of Chinese medicine composition for treating enteroparalysis and seroperitoneum is made of: trigone the following Chinese medicine material of quality proportioning 10~20 parts, 15~25 parts of curcuma zedoary, 10~20 parts of Cortex Magnoliae Officinalis, 20~40 parts of saltcake, 20~40 parts of radish seed, castor bean 20~40 Part, 15~25 parts of the root of gansui, 20~30 parts of peppermint, 5~20 parts of Chinese prickly ash, 5~20 parts of agalloch eaglewood, 20~40 parts of turpentine.

2. Chinese medicine composition as described in claim 1, it is characterised in that the composition material quality composition is as follows: trigone 15 Part, 20 parts of curcuma zedoary, 15 parts of Cortex Magnoliae Officinalis, 30 parts of saltcake, 30 parts of radish seed, 30 parts of castor bean, 20 parts of the root of gansui, 25 parts of peppermint, Chinese prickly ash 10 Part, 10 parts of agalloch eaglewood, 30 parts of turpentine.

3. application of the Chinese medicine composition of any of claims 1 or 2 in the drug of preparation treatment enteroparalysis.

4. application of the Chinese medicine composition of any of claims 1 or 2 in the drug of preparation treatment seroperitoneum.

5. a kind of Chinese medicinal ointment for treating enteroparalysis and seroperitoneum, the Chinese medicinal ointment Chinese medicine material following by quality proportioning It is made: 10~20 parts of trigone, 15~25 parts of curcuma zedoary, 10~20 parts of Cortex Magnoliae Officinalis, 20~40 parts of saltcake, 20~40 parts of radish seed, castor-oil plant 20~40 parts of son, 15~25 parts of the root of gansui, 20~30 parts of peppermint, 5~20 parts of Chinese prickly ash, 5~20 parts of agalloch eaglewood, 20~40 parts of turpentine, bee It is sweet appropriate；The Chinese medicinal ointment the preparation method is as follows:

(1) raw material that formula ratio is weighed according to Chinese medicine composition composition, the raw material other than saltcake, honey is cleaned, spare；

(2) saltcake except in step (1) and the raw material other than honey are soaked in water, water buried 1~2cm of powder, after immersion, water It decocts and extracts 2 times；It is first cooked by slow fire to medicine for 1st time and sufficiently to expand, boil again, keep boiling 15~30 minutes, the dregs of a decoction are filtered, are obtained 1st decoction；The filtering gained dregs of a decoction, the 2nd time plus water, water buried 1~2cm of powder, and were cooked by slow fire to medicine and sufficiently expand, boil again And keep boiling 15~30 minutes, the dregs of a decoction are filtered, the 2nd decoction is obtained；2 decoctions are mixed, are continued with being cooked by slow fire to moisture When evaporation is three point one or so surplus, proper honey is added, continues mild fire heating, constantly stirs to paste is concentrated into, it is cooled to 40~ Saltcake is added at 60 DEG C, stirring to saltcake is completely dissolved in ointment；

(3) ointment obtained by step (2) is dispensed with Chinese medicine special herbal paste porcelain jar or stainless cylinder of steel, is covered after ointment is sufficiently let cool, Cryo-conservation is sealed to get the Chinese medicinal ointment.

6. Chinese medicinal ointment as claimed in claim 5, the Chinese medicinal ointment is made of the following Chinese medicine material of quality proportioning: trigone 15 parts, 20 parts of curcuma zedoary, 15 parts of Cortex Magnoliae Officinalis, 30 parts of saltcake, 30 parts of radish seed, 30 parts of castor bean, 20 parts of the root of gansui, 25 parts of peppermint, Chinese prickly ash 10 parts, 10 parts of agalloch eaglewood, 30 parts of turpentine, appropriate honey.

7. a kind of traditional Chinese powder medicine for treating enteroparalysis and seroperitoneum, the traditional Chinese powder medicine Chinese medicine material following by quality proportioning It is made: 10~20 parts of trigone, 15~25 parts of curcuma zedoary, 10~20 parts of Cortex Magnoliae Officinalis, 20~40 parts of saltcake, 20~40 parts of radish seed, castor-oil plant 20~40 parts, 15~25 parts of the root of gansui, 20~30 parts of peppermint, 5~20 parts of Chinese prickly ash, 5~20 parts of agalloch eaglewood, 20~40 parts of turpentine of son；Institute State traditional Chinese powder medicine the preparation method is as follows:

(1) Chinese medicine material that formula ratio is weighed according to Chinese medicine composition composition, by trigone, curcuma zedoary, Cortex Magnoliae Officinalis, saltcake, radish seed, castor Pockmarks, the root of gansui, peppermint, Chinese prickly ash, agalloch eaglewood, turpentine are ground into 100~200 mesh fine powders, spare；

(2) fine powder for obtaining step (1), the inner wrapping of every bag of 30g is distributed into tulle bag, with polybag vacuum sealing, i.e., Obtain the traditional Chinese powder medicine.

8. traditional Chinese powder medicine as claimed in claim 7, the traditional Chinese powder medicine is made of the following Chinese medicine material of quality proportioning: trigone 15 parts, 20 parts of curcuma zedoary, 15 parts of Cortex Magnoliae Officinalis, 30 parts of saltcake, 30 parts of radish seed, 30 parts of castor bean, 20 parts of the root of gansui, 25 parts of peppermint, Chinese prickly ash 10 parts, 10 parts of agalloch eaglewood, 30 parts of turpentine.